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EC 6.2.1.3 Details
EC number
6.2.1.3
Accepted name
long-chain-fatty-acid—CoA ligase
Reaction
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
Other name(s)
acyl-CoA synthetase,
fatty acid thiokinase (long chain),
acyl-activating enzyme,
palmitoyl-CoA synthase,
lignoceroyl-CoA synthase,
arachidonyl-CoA synthetase,
acyl coenzyme A synthetase,
acyl-CoA ligase,
palmitoyl coenzyme A synthetase,
thiokinase,
palmitoyl-CoA ligase,
acyl-coenzyme A ligase,
fatty acid CoA ligase,
long-chain fatty acyl coenzyme A synthetase,
oleoyl-CoA synthetase,
stearoyl-CoA synthetase,
long chain fatty acyl-CoA synthetase,
long-chain acyl CoA synthetase,
fatty acid elongase,
LCFA synthetase,
pristanoyl-CoA synthetase,
ACS3,
long-chain acyl-CoA synthetase I,
long-chain acyl-CoA synthetase II,
fatty acyl-coenzyme A synthetase,
long-chain acyl-coenzyme A synthetase,
FAA1
Systematic name
long-chain fatty acid:CoA ligase (AMP-forming)
CAS registry number
9013-18-7
Comment
Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.
History
created 1961, modified 1989, modified 2011
EC Tree
6.2.1.21 created 1986, deleted 2001