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EC 6.2.1.3 Details
EC number
6.2.1.3
Accepted name
long-chain-fatty-acid—CoA ligase
Reaction
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
Other name(s)
acyl-CoA synthetase, fatty acid thiokinase (long chain), acyl-activating enzyme, palmitoyl-CoA synthase, lignoceroyl-CoA synthase, arachidonyl-CoA synthetase, acyl coenzyme A synthetase, acyl-CoA ligase, palmitoyl coenzyme A synthetase, thiokinase, palmitoyl-CoA ligase, acyl-coenzyme A ligase, fatty acid CoA ligase, long-chain fatty acyl coenzyme A synthetase, oleoyl-CoA synthetase, stearoyl-CoA synthetase, long chain fatty acyl-CoA synthetase, long-chain acyl CoA synthetase, fatty acid elongase, LCFA synthetase, pristanoyl-CoA synthetase, ACS3, long-chain acyl-CoA synthetase I, long-chain acyl-CoA synthetase II, fatty acyl-coenzyme A synthetase, long-chain acyl-coenzyme A synthetase, FAA1
Systematic name
long-chain fatty acid:CoA ligase (AMP-forming)
CAS registry number
9013-18-7
Comment
Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.
History
created 1961, modified 1989, modified 2011
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
4 Lyases
5 Isomerases
6 Ligases
6.1 Forming carbon-oxygen bonds
6.2 Forming carbon-sulfur bonds
6.2.1 Acid-thiol ligases
6.2.1.1 acetate—CoA ligase
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.3 long-chain-fatty-acid—CoA ligase
6.2.1.4 succinate—CoA ligase (GDP-forming)
6.2.1.5 succinate—CoA ligase (ADP-forming)
6.2.1.6 glutarate—CoA ligase
6.2.1.7 cholate—CoA ligase
6.2.1.8 oxalate—CoA ligase
6.2.1.9 malate—CoA ligase
6.2.1.10 carboxylic acid—CoA ligase (GDP-forming)
6.2.1.11 biotin—CoA ligase
6.2.1.12 4-coumarate—CoA ligase
6.2.1.13 acetate—CoA ligase (ADP-forming)
6.2.1.14 6-carboxyhexanoate—CoA ligase
6.2.1.15 arachidonate—CoA ligase
6.2.1.16 acetoacetate—CoA ligase
6.2.1.17 propionate—CoA ligase
6.2.1.18 citrate—CoA ligase
6.2.1.19 long-chain-fatty-acid—protein ligase
6.2.1.20 long-chain-fatty-acid—[acyl-carrier-protein] ligase
6.2.1.21 created 1986, deleted 2001
6.2.1.22 [citrate (pro-3S)-lyase] ligase
6.2.1.23 dicarboxylate—CoA ligase
6.2.1.24 phytanate—CoA ligase
6.2.1.25 benzoate—CoA ligase
6.2.1.26 o-succinylbenzoate—CoA ligase
6.2.1.27 4-hydroxybenzoate—CoA ligase
6.2.1.28 3α,7α-dihydroxy-5β-cholestanate—CoA ligase
6.2.1.29 (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate—CoA ligase
6.2.1.30 phenylacetate—CoA ligase
6.2.1.31 2-furoate—CoA ligase
6.2.1.32 anthranilate—CoA ligase
6.2.1.33 4-chlorobenzoate—CoA ligase
6.2.1.34 trans-feruloyl-CoA synthase
6.2.1.35 acetate—[acyl-carrier protein] ligase
6.2.1.36 3-hydroxypropionyl-CoA synthase
6.2.1.37 3-hydroxybenzoate—CoA ligase
6.2.1.38 (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
6.2.1.39 [butirosin acyl-carrier protein]—L-glutamate ligase
6.2.1.40 4-hydroxybutyrate—CoA ligase (AMP-forming)
6.2.1.41 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate—CoA ligase
6.2.1.42 3-oxocholest-4-en-26-oate—CoA ligase
6.2.1.43 2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase
6.2.1.44 3-(methylthio)propionyl—CoA ligase
6.2.1.45 E1 ubiquitin-activating enzyme
6.2.1.46 L-allo-isoleucine—holo-[CmaA peptidyl-carrier protein] ligase
6.2.1.47 medium-chain-fatty-acid—[acyl-carrier-protein] ligase
6.2.1.48 carnitine—CoA ligase
6.2.1.49 long-chain fatty acid adenylyltransferase FadD28
6.2.1.50 4-hydroxybenzoate adenylyltransferase FadD22
6.2.1.51 4-hydroxyphenylalkanoate adenylyltransferase FadD29
6.2.1.52 L-firefly luciferin—CoA ligase
6.2.1.53 L-proline—[L-prolyl-carrier protein] ligase
6.2.1.54 D-alanine—[D-alanyl-carrier protein] ligase
6.2.1.55 E1 SAMP-activating enzyme
6.2.1.56 4-hydroxybutyrate—CoA ligase (ADP-forming)
6.2.1.57 long-chain fatty acid adenylase/transferase FadD23
6.2.1.58 isophthalate—CoA ligase
6.2.1.59 long-chain fatty acid adenylase/transferase FadD26
6.2.1.60 marinolic acid—CoA ligase
6.2.1.61 salicylate—[aryl-carrier protein] ligase
6.2.1.62 3,4-dihydroxybenzoate—[aryl-carrier protein] ligase
6.2.1.63 L-arginine—[L-arginyl-carrier protein] ligase
6.2.1.64 E1 NEDD8-activating enzyme
6.2.1.65 salicylate—CoA ligase
6.2.1.66 glyine—[glycyl-carrier protein] ligase
6.2.1.67 L-alanine—[L-alanyl-carrier protein] ligase
6.2.1.68 L-glutamate—[L-glutamyl-carrier protein] ligase
6.2.1.69 L-cysteine—[L-cysteinyl-carrier protein] ligase
6.2.1.70 L-threonine—[L-threonyl-carrier protein] ligase
6.2.1.71 2,3-dihydroxybenzoate—[aryl-carrier protein] ligase
6.2.1.72 L-serine—[L-seryl-carrier protein] ligase
6.2.1.73 L-tryptophan—[L-tryptophyl-carrier protein] ligase
6.2.1.74 3-amino-5-hydroxybenzoate—[acyl-carrier protein] ligase
6.2.1.75 indoleacetate—CoA ligase
6.2.1.76 malonate—CoA ligase
6.2.2 Amide---thiol ligases
6.3 Forming carbon-nitrogen bonds
6.4 Forming carbon-carbon bonds
6.5 Forming phosphoric-ester bonds
6.6 Forming nitrogen—metal bonds
6.7 Forming nitrogen-nitrogen bonds
7 Translocases