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EC 7.1.1.2 Details
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EC number
7.1.1.2
Accepted name
NADH:ubiquinone reductase (H+-translocating)
Reaction
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]
Other name(s)
ubiquinone reductase (ambiguous), type 1 dehydrogenase, complex 1 dehydrogenase, coenzyme Q reductase (ambiguous), complex I (electron transport chain), complex I (mitochondrial electron transport), complex I (NADH:Q1 oxidoreductase), dihydronicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous), DPNH-coenzyme Q reductase (ambiguous), DPNH-ubiquinone reductase (ambiguous), mitochondrial electron transport complex 1, mitochondrial electron transport complex I, NADH coenzyme Q1 reductase, NADH-coenzyme Q oxidoreductase (ambiguous), NADH-coenzyme Q reductase (ambiguous), NADH-CoQ oxidoreductase (ambiguous), NADH-dehydrogenase (ubiquinone) (ambiguous), NADH-CoQ reductase (ambiguous), NADH-ubiquinone reductase (ambiguous), NADH-ubiquinone oxidoreductase (ambiguous), NADH-ubiquinone-1 reductase, reduced nicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous), NADH:ubiquinone oxidoreductase complex, NADH-Q6 oxidoreductase (ambiguous), electron transfer complex I, NADH2 dehydrogenase (ubiquinone)
Systematic name
NADH:ubiquinone oxidoreductase
CAS registry number
9028-04-0
Comment
The enzyme is a very large complex that participates in electron transfer chains of mitochondria and aerobic bacteria, transferring electrons from NADH to the ubiquinone pool. Reversed electron transport through this enzyme can reduce NAD+ to NADH.
History
created 1961 as EC 1.6.5.3, deleted 1965, reinstated 1983, modified 2011, modified 2013, transferred 2018 to EC 7.1.1.2
EC Browser
1 Oxidoreductases (9857 organisms) download 4187764 sequences with EC number 1 in fasta format download 4187764 sequences with EC number 1 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 1) as tabstop separated file
2 Transferases (8009 organisms) download 11480659 sequences with EC number 2 in fasta format download 11480659 sequences with EC number 2 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 2) as tabstop separated file
3 Hydrolases (11488 organisms) download 6152646 sequences with EC number 3 in fasta format download 6152646 sequences with EC number 3 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 3) as tabstop separated file
4 Lyases (5150 organisms) download 3095231 sequences with EC number 4 in fasta format download 3095231 sequences with EC number 4 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 4) as tabstop separated file
5 Isomerases (2116 organisms) download 1846889 sequences with EC number 5 in fasta format download 1846889 sequences with EC number 5 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 5) as tabstop separated file
6 Ligases (1602 organisms) download 2871876 sequences with EC number 6 in fasta format download 2871876 sequences with EC number 6 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 6) as tabstop separated file
7 Translocases (1115 organisms) download 2661565 sequences with EC number 7 in fasta format download 2661565 sequences with EC number 7 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 7) as tabstop separated file