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Information on EC 1.1.1.168 - 2-dehydropantolactone reductase (Re-specific)
for references in articles please use BRENDA:EC1.1.1.168
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.168 2-dehydropantolactone reductase (Re-specific)
IUBMB Comments
The yeast enzyme differs from that from Escherichia coli [EC 1.1.1.214 2-dehydropantolactone reductase (Si-specific)], which is specific for the Si-face of NADP+, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase.
The enzyme appears in viruses and cellular organisms
showSynonyms
nadph-dependent aldo-keto reductase, ketopantoyl lactone reductase, nadph-dependent conjugated polyketone reductase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
(R)-pantoyl-lactone:NADP+ oxidoreductase (A-specific)
-
-
-
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2-dehydropantoyl-lactone reductase
-
-
-
-
2-dehydropantoyl-lactone reductase (A-specific)
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-
-
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2-ketopantoyl lactone reductase
-
-
-
-
AKR
CPR
ketopantoyl lactone reductase
-
-
-
-
NADPH-dependent aldo-keto reductase
NADPH-dependent conjugated polyketone reductase
reductase, 2-oxopantoyl lactone
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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-
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-
redox reaction
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-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
phosphopantothenate biosynthesis II
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SYSTEMATIC NAME
IUBMB Comments
(R)-pantolactone:NADP+ oxidoreductase (Re-specific)
The yeast enzyme differs from that from Escherichia coli [EC 1.1.1.214 2-dehydropantolactone reductase (Si-specific)], which is specific for the Si-face of NADP+, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase.
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CAS REGISTRY NUMBER
COMMENTARY
37211-75-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dihydro-4,4-diethyl-2,3-furanedione + NADPH
?
-
Substrates: -
Products: -
Products: -
?
dihydro-4-methyl-4-propyl-2,3-furanedione + NADPH
?
-
Substrates: -
Products: -
Products: -
?
dihydro-5-(2-butyl)-4-methyl-4-ethyl-2,3-furanedione + NADPH
?
-
Substrates: -
Products: -
Products: -
?
dihydro-5-(2-pentyl)-4,4-dimethyl-2,3-furanedione + NADPH
?
-
Substrates: -
Products: -
Products: -
?
dihydro-5-(2-pentyl)-4-methyl-4-propyl-2,3-furanedione + NADPH
?
-
Substrates: -
Products: -
Products: -
?
dihydro-5-(3-pentyl)-4,4-dimethyl-2,3-furanedione + NADPH
?
-
Substrates: -
Products: -
Products: -
?
dihydro-5-isopropyl-4,4-dimethyl-2,3-furanedione + NADPH
?
-
Substrates: -
Products: -
Products: -
?
ketopantoyl lactone + NADPH
D-(-)-pantoyl lactone
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Substrates: and its derivatives
Products: -
Products: -
?
methyl 2-oxopropanoate + NADPH + H+
methyl (2R)-2-hydroxypropanoate + NADP+
Substrates: 0.501% activity compared to 2-dehydropantolactone
Products: -
Products: -
?
methyl oxo(phenyl)acetate + NADPH + H+
methyl (2R)-hydroxy(phenyl)acetate + NADP+
Substrates: 3.94% activity compared to 2-dehydropantolactone
Products: -
Products: -
?
pyridine 3-aldehyde + NADPH + H+
(pyridin-3-yl)methanol + NADP+
Substrates: 0.538% activity compared to 2-dehydropantolactone
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
Substrates: 98% conversion and 99% enantiomeric excess within 2 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
-
Substrates: 98% conversion and 99% enantiomeric excess within 2 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
-
Substrates: 98% conversion and 99% enantiomeric excess within 2 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
Substrates: 98% conversion and 99% enantiomeric excess within 2 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
-
Substrates: 98% conversion and 99% enantiomeric excess within 2 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
-
Substrates: 98% conversion and 99% enantiomeric excess within 2 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
Substrates: -
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
Substrates: 100% activity, 99% conversion and more than 99% enantiomeric excess within 5 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
Substrates: -
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
Substrates: 100% activity, 99% conversion and more than 99% enantiomeric excess within 5 h
Products: -
Products: -
?
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
-
Substrates: -
Products: -
Products: -
?
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
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Substrates: -
Products: -
Products: -
ir
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
-
Substrates: -
Products: -
Products: -
ir
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
-
Substrates: -
Products: -
Products: -
?
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
-
Substrates: -
Products: -
Products: -
?
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
-
Substrates: -
Products: -
Products: -
?
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
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Substrates: -
Products: -
Products: -
ir
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
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Substrates: -
Products: -
Products: -
ir
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
-
Substrates: -
Products: -
Products: -
ir
ethyl 2-oxopropanoate + NADPH + H+
ethyl (2R)-2-hydroxypropanoate + NADP+
Substrates: 0.496% activity compared to 2-dehydropantolactone
Products: -
Products: -
?
ethyl 2-oxopropanoate + NADPH + H+
ethyl (2R)-2-hydroxypropanoate + NADP+
Substrates: 0.496% activity compared to 2-dehydropantolactone
Products: -
Products: -
?
ethyl oxo(phenyl)acetate + NADPH + H+
ethyl (2R)-hydroxy(phenyl)acetate + NADP+
Substrates: 3.45% activity compared to 2-dehydropantolactone
Products: -
Products: -
?
ethyl oxo(phenyl)acetate + NADPH + H+
ethyl (2R)-hydroxy(phenyl)acetate + NADP+
Substrates: 3.45% activity compared to 2-dehydropantolactone
Products: -
Products: -
?
isatin + NADPH
?
-
Substrates: and its derivatives
Products: -
Products: -
?
additional information
?
-
Substrates: the enzyme does not reduce 4-nitrobenzaldehyde
Products: -
Products: -
-
additional information
?
-
-
Substrates: the enzyme does not reduce 4-nitrobenzaldehyde
Products: -
Products: -
-
additional information
?
-
Substrates: the enzyme does not reduce 4-nitrobenzaldehyde
Products: -
Products: -
-
additional information
additional information
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Substrates: carbonyl reductase specifically catalyzing the reduction of conjugated polyketones
Products: -
Products: -
?
additional information
additional information
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Substrates: carbonyl reductase specifically catalyzing the reduction of conjugated polyketones
Products: -
Products: -
?
additional information
additional information
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-
Substrates: keto-omega-methylpantoyl lactone is the only analog of ketopantoyl lactone tested that is a substrate
Products: -
Products: -
?
additional information
additional information
-
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Substrates: keto-omega-methylpantoyl lactone is the only analog of ketopantoyl lactone tested that is a substrate
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: carbonyl reductase specifically catalyzing the reduction of conjugated polyketones
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: not: several other 2-keto acids
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: not: several other 2-keto acids
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: not: ketopantoic acid
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: not: ketopantoic acid
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: not: ketopantoic acid
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: not: ketopantoic acid
Products: -
Products: -
?
additional information
additional information
-
-
Substrates: not: linear form of oxopantoate
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
Substrates: 98% conversion and 99% enantiomeric excess within 2 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
-
Substrates: 98% conversion and 99% enantiomeric excess within 2 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
-
Substrates: 98% conversion and 99% enantiomeric excess within 2 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
Substrates: 98% conversion and 99% enantiomeric excess within 2 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
-
Substrates: 98% conversion and 99% enantiomeric excess within 2 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
-
Substrates: 98% conversion and 99% enantiomeric excess within 2 h
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
Substrates: -
Products: -
Products: -
?
2-dehydropantolactone + NADPH + H+
(R)-pantolactone + NADP+
Substrates: -
Products: -
Products: -
?
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
-
Substrates: -
Products: -
Products: -
ir
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
-
Substrates: -
Products: -
Products: -
ir
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
-
Substrates: -
Products: -
Products: -
?
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
-
Substrates: -
Products: -
Products: -
ir
2-dehydropantoyl lactone + NADPH
(R)-pantoyl lactone + NADP+
-
Substrates: -
Products: -
Products: -
ir
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
1 mM Ni2+ and Ca2+ have almost no influence over the enzyme activity
additional information
-
1 mM Ni2+ and Ca2+ have almost no influence over the enzyme activity
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Polyketones
-
cyclohexenediol-1,2,3,4-tetraone; e.g. parabanic acid
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Cataract
Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease.
Colonic Neoplasms
Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells.
Diabetic Nephropathies
Identification of a renal-specific oxido-reductase in newborn diabetic mice.
Diabetic Retinopathy
Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease.
Neoplasms
Inhibitory effects of polyphenols isolated from Rhus verniciflua on Aldo-keto reductase family 1 B10.
Uveitis
Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
20.4
2-dehydropantolactone
mutant enzyme H128A, at pH 7.0 and 30°C
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
6.01
2-dehydropantolactone
mutant enzyme H128A, at pH 7.0 and 30°C
15.5
2-dehydropantolactone
mutant enzyme T30A, at pH 7.0 and 30°C
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.295
2-dehydropantolactone
mutant enzyme H128A, at pH 7.0 and 30°C
4.43
2-dehydropantolactone
mutant enzyme T30A, at pH 7.0 and 30°C
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.1 - 5.6
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30
40