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Information on EC 1.1.1.189 - prostaglandin-E2 9-reductase

for references in articles please use BRENDA:EC1.1.1.189

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IUBMB Comments

Reduces prostaglandin E2 to prostaglandin F2α. A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds. May be identical with EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+).

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
pge2-9-ketoreductase, pge2-9-k, pge 9-ketoreductase, prostaglandin e2 9-ketoreductase, pge2 9-ketoreductase, 9-kpr, prostaglandin-e2 9-reductase, pge2-9-or, prostaglandin 9-ketoreductase/carbonyl reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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