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Information on EC 1.1.1.191 - indole-3-acetaldehyde reductase (NADPH)
for references in articles please use BRENDA:EC1.1.1.191
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.191 indole-3-acetaldehyde reductase (NADPH)
The enzyme appears in viruses and cellular organisms
showSynonyms
indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase
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-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(indol-3-yl)ethanol + NADP+ = (indol-3-yl)acetaldehyde + NADPH + H+
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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-
-
-
redox reaction
-
-
-
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reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
L-tryptophan degradation X (mammalian, via tryptamine)
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SYSTEMATIC NAME
IUBMB Comments
(indol-3-yl)ethanol:NADP+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
58875-05-1
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
butyraldehyde + NADPH
butanol + NADP+
-
Substrates: low activity
Products: -
Products: -
?
dihydroxyacetonephosphate + NADPH
glycerol 1-phosphate + NADP+
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Substrates: well accepted substrate
Products: -
Products: -
?
indole-3-aldehyde + NADPH
indole-3-ol + NADP+
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Substrates: 19% of the activity of indole-3-acetaldehyde
Products: -
Products: -
?
phenylacetone + NADPH
phenylethanol + NADP+
-
Substrates: low activity
Products: -
Products: -
?
propionaldehyde + NADPH
propanol + NADP+
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Substrates: very low activity only for isoenzyme TL
Products: -
Products: -
?
trans-cinnamaldehyde + NADPH
(2E)-3-phenylprop-2-en-1-ol + NADP+
-
Substrates: very low activity
Products: -
Products: -
?
acetaldehyde + NADPH + H+
ethanol + NADP+
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Substrates: 5fold higher activity than for indole-3-acetaldehyde
Products: -
Products: -
?
acetaldehyde + NADPH + H+
ethanol + NADP+
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Substrates: very low activity only for isoenzyme TH
Products: -
Products: -
?
acetaldehyde + NADPH + H+
ethanol + NADP+
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Substrates: very low activity
Products: -
Products: -
?
benzaldehyde + NADPH
benzyl alcohol + NADP+
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Substrates: 65% of the activity compared to indole-3-acetaldehyde
Products: -
Products: -
?
benzaldehyde + NADPH
benzyl alcohol + NADP+
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Substrates: 2.5fold higher activity than for indole-3-acetaldehyde
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
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Substrates: -
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
ir
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: substrates hold key positions in the regulation of indole-3-acetic acid content in higher plants
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
phenylacetaldehyde + NADPH + H+
phenylethanol + NADP+
-
Substrates: 2.4fold higher activity than for indole-3-acetaldehyde
Products: -
Products: -
?
phenylacetaldehyde + NADPH + H+
phenylethanol + NADP+
-
Substrates: well accepted substrate
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
ir
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: substrates hold key positions in the regulation of indole-3-acetic acid content in higher plants
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
indole-3-acetaldehyde + NADPH
indole-3-ethanol + NADP+
-
Substrates: -
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NADP+
-
non-competitive inhibition, half-maximal inhibition at 0.2 mM
p-chloromercuriphenylsulfonic acid
-
46% inhibition at 0.1 mM
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
maximum enzyme activity from cultures after 48 h
brenda
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). I3ACR_SCHPO
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
284
0
31570
Swiss-Prot
-
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
32000
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bower, P.J.; Brown, H.M.; Purves, W.K.
Auxin biogenesis. Subcellular compartimentation of indoleacetaldehyde reductases in cucumber seedlings
Plant Physiol.
57
850-854
1976
Cucumis sativus
brenda
Brown, H.M.; Purves, W.K.
Isolation and characterization of indole-3-acetaldehyde reductases from Cucumis sativus
J. Biol. Chem.
251
907-913
1976
Cucumis sativus
brenda
Brown, H.M.; Purves, W.K.
Indoleacetaldehyde reductase of Cucumis sativus L. Kinetic properties and role in auxin biosynthesis
Plant Physiol.
65
107-113
1980
Cucumis sativus
brenda
Ludwig-Muller, J.; Hilgenberg, W.
Purification of NADPH-specific indole-3-acetaldehyde reductase from Cucumis sativus by two-dimensional native polyacrylamide gel electrophoresis
Physiol. Plant.
77
613-619
1989
Cucumis sativus
-
brenda
Ludwig-Muller, J.; Schramm, P.; Hilgenberg, W.
Indole-3-acetaldehyde reductase in Phycomyces blakesleeanus. Characterization of the enzyme
Physiol. Plant.
80
472-478
1990
Phycomyces blakesleeanus
-
brenda
Ludwig-Muller, J.; Hilgenberg, W.
Identification of indole-3-acetaldehyde and indole-3-acetaldehyde reductase in Chinese cabbage
Physiol. Plant.
80
541-548
1990
Arabidopsis thaliana, Brassica napus, Brassica oleracea, Brassica rapa subsp. pekinensis, Sinapis alba
-
brenda
EXTERNAL LINKS (specific for EC-Number 1.1.1.191)
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