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Information on EC 1.1.1.203 - uronate dehydrogenase

for references in articles please use BRENDA:EC1.1.1.203

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IUBMB Comments

Requires Mg2+. The enzyme, characterized from the bacterium Agrobacterium fabrum, participates in oxidative degradation pathways for galacturonate and glucuronate. The enzyme can only accept the β anomeric form of the substrate . The 1,5-lactone product is rather stable at cytosolic pH and does not hydrolyse spontaneously at a substantial rate.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
uronate dehydrogenase, galur, uronic acid dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
beta-D-galacturonate + NAD+ = D-galactaro-1,5-lactone + NADH + H+
show the reaction diagram
(1)
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beta-D-glucuronate + NAD+ = D-glucaro-1,5-lactone + NADH + H+
show the reaction diagram
(2)
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PATHWAY SOURCE
PATHWAYS
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