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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
6-pyruvoyl tetrahydropterin (2'-oxo)reductase, 6-pyruvoyl-tetrahydropterin 2'-reductase, 6-pyruvoyltetrahydropterin reductase, 6PPH4(2'-oxo) reductase, pyruvoyl-tetrahydropterin reductase, more
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6-pyruvoyl tetrahydropterin (2'-oxo)reductase
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6-pyruvoyl-tetrahydropterin 2'-reductase
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6-pyruvoyltetrahydropterin reductase
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6PPH4(2'-oxo) reductase
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pyruvoyl-tetrahydropterin reductase
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6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ = 6-pyruvoyltetrahydropterin + NADPH + H+
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MetaCyc
erythro-tetrahydrobiopterin biosynthesis I, threo-tetrahydrobiopterin biosynthesis
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6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase
Not identical with EC 1.1.1.153 sepiapterin reductase.
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4-nitrobenzaldehyde + NADPH
4-nitrobenzylalcohol + NADP+
6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
menadione + NADPH
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Substrates: -
Products: -
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Phenanthrenequinone + NADPH
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Substrates: -
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additional information
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Substrates: typical substrates of aldose reductase tested as substrates
Products: -
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4-nitrobenzaldehyde + NADPH
4-nitrobenzylalcohol + NADP+
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Substrates: -
Products: -
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4-nitrobenzaldehyde + NADPH
4-nitrobenzylalcohol + NADP+
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Substrates: -
Products: -
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6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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Substrates: -
Products: -
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6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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Substrates: involved in de novo biosynthesis of tetrahydrobiopterin
Products: -
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6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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Substrates: -
Products: -
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6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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Substrates: involved in de novo biosynthesis of tetrahydrobiopterin
Products: -
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6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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Substrates: -
Products: -
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6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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Substrates: -
Products: -
ir
6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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Substrates: involved in de novo biosynthesis of tetrahydrobiopterin
Products: -
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6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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Substrates: involved in de novo biosynthesis of tetrahydrobiopterin
Products: -
ir
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6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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Substrates: involved in de novo biosynthesis of tetrahydrobiopterin
Products: -
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6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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Substrates: involved in de novo biosynthesis of tetrahydrobiopterin
Products: -
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6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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Substrates: involved in de novo biosynthesis of tetrahydrobiopterin
Products: -
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6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
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Substrates: involved in de novo biosynthesis of tetrahydrobiopterin
Products: -
ir
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0.1
4-nitrobenzaldehyde
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0.001
6-pyruvoyltetrahydropterin
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bovine
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brenda
enzyme is identical to aldose reductase
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brenda
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brenda
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brenda
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brenda
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highest concentration in striatum and midbrain
brenda
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brenda
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brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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J0QVL7_HELPX
112
0
12904
TrEMBL
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I9XG54_HELPX
136
0
15504
TrEMBL
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J0JK55_HELPX
112
0
12868
TrEMBL
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I9QVW9_HELPX
136
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15506
TrEMBL
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37000
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SDS-PAGE, gel filtration
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monomer
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SDS-PAGE, gel filtration
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Milstien, S.; Kaufman, S.
Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates
Biochem. Biophys. Res. Commun.
128
1099-1107
1985
Bos taurus, Rattus norvegicus
brenda
Milstien, S.; Kaufman, S.
The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl tetrahydropterin (2-oxo)reductase
J. Biol. Chem.
264
8066-8073
1989
Rattus norvegicus
brenda
Steinerstauch, P.; Wermuth, B.; Leimbacher, W.; Curtius, H.C.
Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase
Biochem. Biophys. Res. Commun.
164
1130-1136
1989
Homo sapiens
brenda
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