We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Information on EC 1.1.1.225 - chlordecone reductase for references in articles please use BRENDA:EC1.1.1.225Word Map on EC 1.1.1.225
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
The enzyme appears in viruses and cellular organisms
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
chlordecone alcohol + NADP+ = chlordecone + NADPH + H+
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
chlordecone-alcohol:NADP+ 2-oxidoreductase
Chlordecone is an organochlorine pesticide.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
reductase, chlordecone
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
-
-
brenda
no activity in Cavia porcellus
-
-
-
brenda
no activity in Mesocricetus auratus
-
-
-
brenda
no activity in Mus musculus
-
-
-
brenda
no activity in Rattus norvegicus
-
-
-
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH
chlordecone alcohol + NADP+
1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH
chlordecone alcohol + NADP+
-
-
-
?
1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH
chlordecone alcohol + NADP+
-
organochlorine pesticide, trivial names: chlordecone or kepone
-
?
1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH
chlordecone alcohol + NADP+
-
-
-
?
1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH
chlordecone alcohol + NADP+
-
organochlorine pesticide, trivial names: chlordecone or kepone
-
?
1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH
chlordecone alcohol + NADP+
-
-
-
?
1,1alpha,3,3beta,4,5,5,5alpha,5beta,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one + NADPH
chlordecone alcohol + NADP+
-
organochlorine pesticide, trivial names: chlordecone or kepone
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
-
no activity with NADH
-
NADPH
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Cu2+
-
slight inhibition
Ethacrynic acid
-
-
Hg2+
-
slight inhibition
indomethacin
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
strong inhibition
p-chloromercuribenzoate
-
-
quercetin
-
-
quercetin
-
weak inhibition
additional information
-
not inhibited by phenobarbital
-
additional information
-
not inhibited by phenobarbital
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0026 - 0.003
Chlordecone
0.0026
Chlordecone
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
7.5
-
2 optima: pH 7.5 and 9.0
9
-
2 optima: pH 7.5 and 9.0
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
additional information
-
found in all tissues, highest activity in liver, intestine and kidney
brenda
-
-
brenda
-
-
brenda
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expressed in Escherichia coli
-
gene is located on chromosome 10 at 10p14-p15
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
AK1C4_HUMAN
323
37067
Swiss-Prot
AK1C4_MACFA
323
37117
Swiss-Prot
AK1C4_MACFU
323
37103
Swiss-Prot
A0A061I7S4_CRIGR
102
12075
TrEMBL
A0A061IA38_CRIGR
323
36909
TrEMBL
A0A061IA66_CRIGR
323
37015
TrEMBL
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Molowa, D.T.; Wrighton, S.A.; Blanke, R.V.; Guzelian, P.S.
Characterization of a unique aldo-keto reductase responsible for the reduction of chlordecone in the liver of the gerbil and man
J. Toxicol. Environ. Health
17
375-384
1986
Homo sapiens, Meriones unguiculatus, no activity in Cavia porcellus, no activity in Mesocricetus auratus, no activity in Mus musculus, no activity in Rattus norvegicus, Oryctolagus cuniculus
brenda
Winters, C.J.; Molowa, D.T.; Guzelian, P.S.
Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase
Biochemistry
29
1080-1087
1990
Homo sapiens
brenda
Molowa, D.T.; Shayne, A.G.; Guzelian, P.S.
Purification and characterization of chlordecone reductase from human liver
J. Biol. Chem.
261
12624-12627
1986
Homo sapiens, Meriones unguiculatus, no activity in Mesocricetus auratus, no activity in Mus musculus, no activity in Rattus norvegicus, Oryctolagus cuniculus
brenda
Khanna, M.; Qin, I.; Belkin, S.; Sparkes, R.S.; Cheng, K.C.
Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization
Genomics
25
588-590
1995
Homo sapiens
brenda
html completed