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Information on EC 1.1.1.284 - S-(hydroxymethyl)glutathione dehydrogenase

for references in articles please use BRENDA:EC1.1.1.284

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IUBMB Comments

The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22, S-(hydroxymethyl)glutathione synthase. This enzyme forms part of the pathway that detoxifies formaldehyde, since the product is hydrolysed by EC 3.1.2.12, S-formylglutathione hydrolase. The human enzyme belongs to the family of zinc-dependent alcohol dehydrogenases. Also specifically reduces S-nitrosylglutathione.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
nitroreductase, gsnor, s-nitrosoglutathione reductase, gsno reductase, gsnor1, adh iii, gsno-r, alcohol dehydrogenase class iii, slgsnor, formic dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
formaldehyde oxidation II (glutathione-dependent), protein S-nitrosylation and denitrosylation