Reference on EC 1.1.1.300 - NADP-retinol dehydrogenase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Haeseleer, F.; Huang, J.; Lebiodas, L.; Saari, J.C.; Palczewski, K.
Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal
J. Biol. Chem.
273
21790-21799
1998
Homo sapiens (O75911)
Belyaeva, O.V.; Stetsenko, A.V.; Nelson, P.; Kedishvili, N.Y.
Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines
Biochemistry
42
14838-14845
2003
Homo sapiens
Kedishvili, N.Y.; Chumakova, O.V.; Chetyrkin, S.V.; Belyaeva, O.V.; Lapshina, E.A.; Lin, D.W.; Matsumura, M.; Nelson, P.S.
Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)
J. Biol. Chem.
277
28909-28915
2002
Homo sapiens, Homo sapiens (Q8TC12)
Haeseleer, F.; Jang, G.F.; Imanishi, Y.; Driessen, C.A.; Matsumura, M.; Nelson, P.S.; Palczewski, K.
Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina
J. Biol. Chem.
277
45537-45546
2002
Homo sapiens, Homo sapiens (Q96NR8), Homo sapiens (Q9HBH5)
Markova, N.G.; Pinkas-Sarafova, A.; Karaman-Jurukovska, N.; Jurukovski, V.; Simon, M.
Expression pattern and biochemical characteristics of a major epidermal retinol dehydrogenase
Mol. Genet. Metab.
78
119-135
2003
Homo sapiens
Janecke, A.R.; Thompson, D.A.; Utermann, G.; Becker, C.; Hubner, C.A.; Schmid, E.; McHenry, C.L.; Nair, A.R.; Ruschendorf, F.; Heckenlively, J.; Wissinger, B.; Nurnberg, P.; Gal, A.
Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy
Nat. Genet.
36
850-854
2004
Homo sapiens
Gallego, O.; Belyaeva, O.V.; Porte, S.; Ruiz, F.X.; Stetsenko, A.V.; Shabrova, E.V.; Kostereva, N.V.; Farres, J.; Pares, X.; Kedishvili, N.Y.
Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids
Biochem. J.
399
101-109
2006
Homo sapiens (Q8TC12)
Belyaeva, O.V.; Korkina, O.V.; Stetsenko, A.V.; Kim, T.; Nelson, P.S.; Kedishvili, N.Y.
Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids
Biochemistry
44
7035-7047
2005
Homo sapiens, Homo sapiens (Q96NR8)
Maeda, A.; Maeda, T.; Imanishi, Y.; Kuksa, V.; Alekseev, A.; Bronson, J.D.; Zhang, H.; Zhu, L.; Sun, W.; Saperstein, D.A.; Rieke, F.; Baehr, W.; Palczewski, K.
Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo
J. Biol. Chem.
280
18822-18832
2005
Mus musculus
Kasus-Jacobi, A.; Ou, J.; Birch, D.G.; Locke, K.G.; Shelton, J.M.; Richardson, J.A.; Murphy, A.J.; Valenzuela, D.M.; Yancopoulos, G.D.; Edwards, A.O.
Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo
J. Biol. Chem.
280
20413-20420
2005
Homo sapiens (O75911), Homo sapiens (Q8TC12), Homo sapiens (Q92781), Homo sapiens (Q96NR8), Homo sapiens (Q9HBH5), Homo sapiens (Q9NYR8), Mus musculus (Q9QYF1), Mus musculus
Liden, M.; Eriksson, U.
Understanding retinol metabolism: Structure and function of retinol dehydrogenases
J. Biol. Chem.
281
13001-13004
2006
Bos taurus, Mus musculus
Maeda, A.; Maeda, T.; Imanishi, Y.; Sun, W.; Jastrzebska, B.; Hatala, D.A.; Winkens, H.J.; Hofmann, K.P.; Janssen, J.J.; Baehr, W.; Driessen, C.A.; Palczewski, K.
Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice
J. Biol. Chem.
49
37697-37704
2006
Mus musculus
Ala-Laurila, P.; Kolesnikov, A.V.; Crouch, R.K.; Tsina, E.; Shukolyukov, S.A.; Govardovskii, V.I.; Koutalos, Y.; Wiggert, B.; Estevez, M.E.; Cornwall, M.C.
Visual cycle: Dependence of retinol production and removal on photoproduct decay and cell morphology
J. Gen. Physiol.
128
153-169
2006
Ambystoma tigrinum
Du, K.; Liu, G.F.; Xie, J.P.; Song, X.H.; Li, R.; Liang, B.; Huang, D.Y.
A 27.368 kDa retinal reductase in New Zealand white rabbit liver cytosol encoded by the peroxisomal retinol dehydrogenase-reductase cDNA: purification and characterization of the enzyme
Biochem. Cell Biol.
85
209-217
2007
Oryctolagus cuniculus (Q9GKX2), Oryctolagus cuniculus
Lee, S.; Belyaeva, O.V.; Kedishvili, N.Y.
Effect of lipid peroxidation products on the activity of human retinol dehydrogenase 12 (RDH12) and retinoid metabolism
Biochim. Biophys. Acta
1782
421-425
2008
Homo sapiens
Belyaeva, O.V.; Korkina, O.V.; Stetsenko, A.V.; Kedishvili, N.Y.
Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity
FEBS J.
275
138-147
2008
Homo sapiens (Q8NBN7), Homo sapiens
Song, X.H.; Liang, B.; Liu, G.F.; Li, R.; Xie, J.P.; Du, K.; Huang, D.Y.
Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma
Int. J. Cancer
120
1618-1626
2007
Homo sapiens (Q9BTZ2), Homo sapiens
Kanan, Y.; Wicker, L.D.; Al-Ubaidi, M.R.; Mandal, N.A.; Kasus-Jacobi, A.
Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress
Invest. Ophthalmol. Vis. Sci.
49
1071-1078
2008
Mus musculus, Mus musculus (Q8BYK4), Mus musculus (Q9QYF1)
Keller, B.; Adamski, J.
RDH12, a retinol dehydrogenase causing Lebers congenital amaurosis, is also involved in steroid metabolism
J. Steroid Biochem. Mol. Biol.
104
190-194
2007
Homo sapiens, Mus musculus
Maeda, A.; Maeda, T.; Sun, W.; Zhang, H.; Baehr, W.; Palczewski, K.
Redundant and unique roles of retinol dehydrogenases in the mouse retina
Proc. Natl. Acad. Sci. USA
104
19565-19570
2007
Mus musculus (Q8BYK4)
Lei, Z.; Chen, W.; Zhang, M.; Napoli, J.L.
Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate
Biochemistry
42
4190-4196
2003
Mus musculus
Belyaeva, O.V.; Lee, S.A.; Kolupaev, O.V.; Kedishvili, N.Y.
Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster
Biochim. Biophys. Acta
1790
1266-1273
2009
Drosophila melanogaster (Q7JUS1), Drosophila melanogaster (Q7JYX2), Drosophila melanogaster (Q8MZG9), Drosophila melanogaster (Q9W404)
Pares, X.; Farres, J.; Kedishvili, N.; Duester, G.
Medium- and short-chain dehydrogenase/reductase gene and protein families: Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism
Cell. Mol. Life Sci.
65
3936-3949
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Yao, Y.; Han, W.; Zhou, Y.; Luo, Q.; Li, Z.
Catalytic reaction mechanism of human photoreceptor retinol dehydrogenase: A theoretical study
J. Theor. Comput. Chem.
7
565-578
2008
Homo sapiens
-
Marchette, L.D.; Thompson, D.A.; Kravtsova, M.; Ngansop, T.N.; Mandal, M.N.; Kasus-Jacobi, A.
Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells
Free Radic. Biol. Med.
48
16-25
2010
Mus musculus (Q8BYK4), Mus musculus (Q9QYF1), Mus musculus
Haller, F.; Moman, E.; Hartmann, R.W.; Adamski, J.; Mindnich, R.
Molecular framework of steroid/retinoid discrimination in 17beta-hydroxysteroid dehydrogenase type 1 and photoreceptor-associated retinol dehydrogenase
J. Mol. Biol.
399
255-267
2010
Danio rerio, Homo sapiens (Q9NYR8), Homo sapiens
Tsigelny, I.; Baker, M.E.
Structures important in NAD(P)(H) specificity for mammalian retinol and 11-cis-retinol dehydrogenases
Biochem. Biophys. Res. Commun.
226
118-127
1996
Rattus norvegicus
Lee, S.A.; Belyaeva, O.V.; Kedishvili, N.Y.
Evidence that proteosome inhibitors and chemical chaperones can rescue the activity of retinol dehydrogenase 12 mutant T49M
Chem. Biol. Interact.
191
55-59
2011
Homo sapiens
Chen, C.; Thompson, D.A.; Koutalos, Y.
Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12
J. Biol. Chem.
287
24662-24670
2012
Mus musculus, Mus musculus C57BL/6 x 129/Sv
Wang, H.; Cui, X.; Gu, Q.; Chen, Y.; Zhou, J.; Kuang, Y.; Wang, Z.; Xu, X.
Retinol dehydrogenase 13 protects the mouse retina from acute light damage
Mol. Vis.
18
1021-1030
2012
Mus musculus, Mus musculus C57BL/6 x 129/Sv
Adams, M.K.; Belyaeva, O.V.; Wu, L.; Kedishvili, N.Y.
The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis
J. Biol. Chem.
289
14868-14880
2014
Homo sapiens (O75911), Mus musculus (O88876), Mus musculus (Q8VCH7), Mus musculus
Obrochta, K.M.; Krois, C.R.; Campos, B.; Napoli, J.L.
Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1
J. Biol. Chem.
290
7259-7268
2015
Mus musculus (Q8VCH7)
Hong, S.H.; Ngo, H.P.; Nam, H.K.; Kim, K.R.; Kang, L.W.; Oh, D.K.
Alternative biotransformation of retinal to retinoic acid or retinol by an aldehyde dehydrogenase from Bacillus cereus
Appl. Environ. Microbiol.
82
3940-3946
2016
Bacillus cereus
Lhor, M.; Methot, M.; Horchani, H.; Salesse, C.
Structure of the N-terminal segment of human retinol dehydrogenase 11 and its preferential lipid binding using model membranes
Biochim. Biophys. Acta
1848
878-885
2015
Homo sapiens
Arregi, I.; Climent, M.; Iliev, D.; Strasser, J.; Gouignard, N.; Johansson, J.K.; Singh, T.; Mazur, M.; Semb, H.; Artner, I.; Minichiello, L.; Pera, E.M.
Retinol dehydrogenase-10 regulates pancreas organogenesis and endocrine cell differentiation via paracrine retinoic acid signaling
Endocrinology
157
4615-4631
2016
Mus musculus
Kummalue, T.; Inoue, T.; Miura, Y.; Narusawa, M.; Inoue, H.; Komatsu, N.; Wanachiwanawin, W.; Sugiyama, D.; Tani, K.
Ribosomal protein L11- and retinol dehydrogenase 11-induced erythroid proliferation without erythropoietin in UT-7/Epo erythroleukemic cells
Exp. Hematol.
43
414-423.e1
2015
Homo sapiens
Jiang, W.; Napoli, J.
The retinol dehydrogenase Rdh10 localizes to lipid droplets during acyl ester biosynthesis
J. Biol. Chem.
288
589-597
2013
Mus musculus
Kolesnikov, A.V.; Maeda, A.; Tang, P.H.; Imanishi, Y.; Palczewski, K.; Kefalov, V.J.
Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina
J. Physiol.
593
4923-4941
2015
Mus musculus
Belyaeva, O.V.; Adams, M.K.; Popov, K.M.; Kedishvili, N.Y.
Generation of retinaldehyde for retinoic acid biosynthesis
Biomolecules
10
5
2019
Homo sapiens (Q8IZV5), Mus musculus (Q8VCH7)
Friedl, R.M.; Raja, S.; Metzler, M.A.; Patel, N.D.; Brittian, K.R.; Jones, S.P.; Sandell, L.L.
RDH10 function is necessary for spontaneous fetal mouth movement that facilitates palate shelf elevation
Dis. Model. Mech.
12
dmm039073
2019
Mus musculus (Q8VCH7)
Sarkar, H.; Moosajee, M.
Retinol dehydrogenase 12 (RDH12) Role in vision, retinal disease and future perspectives
Exp. Eye Res.
188
107793
2019
Mus musculus, Homo sapiens (Q96NR8), Homo sapiens
Sarkar, H.; Dubis, A.M.; Downes, S.; Moosajee, M.
Novel heterozygous deletion in retinol dehydrogenase 12 (RDH12) causes familial autosomal dominant retinitis pigmentosa
Front. Genet.
11
335
2020
Homo sapiens (Q96NR8)
Suzuki, H.; Ozaki, Y.; Gen, K.; Kazeto, Y.
Japanese eel retinol dehydrogenases 11/12-like are 17-ketosteroid reductases involved in sex steroid synthesis
Gen. Comp. Endocrinol.
305
113685
2021
Anguilla japonica
Boyer, N.P.; Thompson, D.A.; Koutalos, Y.
Relative contributions of all-trans and 11-cis retinal to formation of lipofuscin and A2E accumulating in mouse retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.
62
1
2021
Mus musculus (D3Z6W3), Mus musculus
Belyaeva, O.V.; Wu, L.; Shmarakov, I.; Nelson, P.S.; Kedishvili, N.Y.
Retinol dehydrogenase 11 is essential for the maintenance of retinol homeostasis in liver and testis in mice
J. Biol. Chem.
293
6996-7007
2018
Mus musculus (Q9QYF1)
Adams, M.K.; Belyaeva, O.V.; Kedishvili, N.Y.
Generation and isolation of recombinant retinoid oxidoreductase complex
Methods Enzymol.
637
77-93
2020
Homo sapiens (O75911), Homo sapiens (Q8IZV5)
Tian, J.; Liu, J.; Li, J.; Zheng, J.; Chen, L.; Wang, Y.; Liu, Q.; Ni, J.
The interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) implied a role of SELENOF in vitamin A metabolism
Nutr. Metab.
15
7
2018
Homo sapiens (Q8TC12), Homo sapiens
Guan, F.; Wang, L.; Hao, S.; Wu, Z.; Bai, J.; Kang, Z.; Zhou, Q.; Chang, H.; Yin, H.; Li, D.; Tian, K.; Ma, J.; Zhang, G.; Zhang, J.
Retinol dehydrogenase-10 promotes development and progression of human glioma via the TWEAK-NF-kappaB axis
Oncotarget
8
105262-105275
2017
Homo sapiens (Q8IZV5), Homo sapiens
Xue, Y.; Sato, S.; Razafsky, D.; Sahu, B.; Shen, S.Q.; Potter, C.; Sandell, L.L.; Corbo, J.C.; Palczewski, K.; Maeda, A.; Hodzic, D.; Kefalov, V.J.
The role of retinol dehydrogenase 10 in the cone visual cycle
Sci. Rep.
7
2390
2017
Mus musculus (Q8VCH7)
Morshedian, A.; Kaylor, J.J.; Ng, S.Y.; Tsan, A.; Frederiksen, R.; Xu, T.; Yuan, L.; Sampath, A.P.; Radu, R.A.; Fain, G.L.; Travis, G.H.
Light-driven regeneration of cone visual pigments through a mechanism involving RGR opsin in Mueller glial cells
Neuron
102
1172-1183.e5
2019
Gallus gallus (A0A3Q3ATC8), Homo sapiens (Q8IZV5), Mus musculus (Q8VCH7)
html completed