Information on EC 1.1.1.312 - 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

for references in articles please use BRENDA:EC1.1.1.312
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IUBMB Comments
The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity. The enzyme was initially believed to act on 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-cis,cis-muconate . However, later studies showed that the substrate is the hemiacetal form , and the product is 2-oxo-2H-pyran-4,6-dicarboxylate [2,4].
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate-6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, CHMS dehydrogenase, CHMS hydrolase, dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ = 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H+
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