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The enzyme appears in viruses and cellular organisms
Synonyms
mevalonic dehydrogenase, more
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mevalonic dehydrogenase
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(R)-mevalonate + NAD+ = mevaldate + NADH + H+
(R)-mevalonate + NAD+ = mevaldate + NADH + H+
stereospecific insertion of hydride into C-5, hydride is added from the re-face of carbonyl group in 3R and 3S-isomers
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(R)-mevalonate + NAD+ = mevaldate + NADH + H+
formation of mevalonic acid is strongly favoured
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(R)-mevalonate + NAD+ = mevaldate + NADH + H+
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(R)-mevalonate:NAD+ oxidoreductase
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(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADPH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NADP+
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
mevaldate + NADH + H+
(R)-mevalonate + NAD+
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Substrates: -
Products: -
r
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
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Substrates: -
Products: -
?
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
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Substrates: -
Products: -
ir
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADPH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NADP+
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Substrates: -
Products: -
?
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADPH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NADP+
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Substrates: -
Products: -
ir
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
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Substrates: -
Products: -
?
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
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Substrates: -
Products: -
ir
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(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
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Substrates: -
Products: -
?
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
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Substrates: -
Products: -
ir
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
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Substrates: -
Products: -
?
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
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Substrates: -
Products: -
ir
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(R,S)-mevaldate
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20 mM or higher
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0.2
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partially purified liver enzyme
0.63
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partially purified liver enzyme
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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ammonium sulfate precipitation, calcium phosphate gel, DEAE-cellulose, bentonite precipitation
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Ngan, H.L.; Popjak, G.
Stereochemistry of the reaction catalyzed by mevaldate reductase
Bioorg. Chem.
4
166-180
1975
Sus scrofa
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brenda
Schlesinger, M.J.; Coon, M.J.
Reduction of mevaldic acid to mevalonic acid by a partially purified enzyme from liver
J. Biol. Chem.
236
2421-2424
1961
Rattus norvegicus, Sus scrofa
brenda
Coon, M.J.; Kupiecki, F.P.; Dekker, E.E.; Schlesinger, M.J.; del Campillo, E.
The enzymic synthesis of branched-chain acids
CIBA Symposium on the biosynthesis of terpenes and sterols (Wolstenholme, G. E. W. ; O. Conner, M. , eds)
62-72
1954
Sus scrofa
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brenda
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