Requires zinc. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, neomycin and ribostamycin. cf. EC 1.1.99.38, 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent).
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The enzyme appears in viruses and cellular organisms
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SYSTEMATIC NAME
IUBMB Comments
2-deoxy-scyllo-inosamine:NAD(P)+ 1-oxidoreductase
Requires zinc. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, neomycin and ribostamycin. cf. EC 1.1.99.38, 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent).
presence of Zn2+. The two zinc coordination motifs associated with catalytic and structural zinc ions are important for the construction of the active site and are highly conserved in this family
heterologous expression of enzyme in combination with Streptomyces kanamyceticus genes kacA, KanF, and kanAB in Streptomyces lividans leads to production of paromamine, an intermediate in kanamycin biosynthesis
heterologous expression of enzyme in combination with Streptomyces kanamyceticus genes kacA, KanF, and kanAB in Streptomyces lividans leads to production of paromamine, an intermediate in kanamycin biosynthesis
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Enzyme Nomenclature
1.1.1.329 2-deoxy-scyllo-inosamine dehydrogenase
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