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Synonyms
hmg-coa reductase, hmgcr, 3-hydroxy-3-methylglutaryl coenzyme a reductase, hmgr, hmg coa reductase, 3-hydroxy-3-methylglutaryl-coa reductase, 3-hydroxy-3-methylglutaryl-coenzyme a reductase, hmgcoa reductase, 3-hydroxy-3-methylglutaryl coa reductase, hmg-coar,
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3-hydroxy-3-methyl-glutaryl CoA reductase
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3-hydroxy-3-methylglutaryl Ccoenzyme A reductase 1
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3-hydroxy-3-methylglutaryl co-enzyme A reductase
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3-hydroxy-3-methylglutaryl CoA reductase
3-hydroxy-3-methylglutaryl coenzyme A reductase
3-hydroxy-3-methylglutaryl coenzyme A reductase 1
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3-hydroxy-3-methylglutaryl-CoA reductase
3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)
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3-hydroxy-3-methylglutaryl-CoA reductase 1
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3-hydroxy-3-methylglutaryl-coenzyme A reductase
3-hydroxy-3-methylglutaryl-coenzyme A reductase 5
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3-hydroxy-3-metylglutaryl coenzyme A reductase
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3-hydroxymethylglutaryl coenzyme A reductase
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acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase
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beta-hydroxy-beta-methylglutaryl coenzyme A reductase
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beta-hydroxy-beta-methylglutaryl-Co A reductase
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HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating CoA)
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hydroxy-3-methylglutoryl-Coenzyme A reductase
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hydroxymethylglutaryl CoA reductase (NADPH)
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hydroxymethylglutaryl-coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate)
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mevalonate:NADP+ oxidoreductase (acetylating CoA)
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microsomal HMG-CoA reductase
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NADPH-hydroxymethylglutaryl-CoA reductase
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S-3-hydroxy-3-methylglutaryl-CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
Ochromonas malhamensis
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl CoA reductase
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3-hydroxy-3-methylglutaryl coenzyme A reductase
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3-hydroxy-3-methylglutaryl coenzyme A reductase
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3-hydroxy-3-methylglutaryl coenzyme A reductase
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3-hydroxy-3-methylglutaryl coenzyme A reductase
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3-hydroxy-3-methylglutaryl coenzyme A reductase
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3-hydroxy-3-methylglutaryl coenzyme A reductase
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3-hydroxy-3-methylglutaryl coenzyme A reductase
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3-hydroxy-3-methylglutaryl coenzyme A reductase
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3-hydroxy-3-methylglutaryl coenzyme A reductase
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3-hydroxy-3-methylglutaryl coenzyme A reductase
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3-hydroxy-3-methylglutaryl-CoA reductase
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3-hydroxy-3-methylglutaryl-CoA reductase
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3-hydroxy-3-methylglutaryl-CoA reductase
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3-hydroxy-3-methylglutaryl-CoA reductase
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3-hydroxy-3-methylglutaryl-CoA reductase
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3-hydroxy-3-methylglutaryl-CoA reductase
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3-hydroxy-3-methylglutaryl-CoA reductase
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3-hydroxy-3-methylglutaryl-CoA reductase
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3-hydroxy-3-methylglutaryl-CoA reductase
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3-hydroxy-3-methylglutaryl-CoA reductase
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3-hydroxy-3-methylglutaryl-CoA reductase
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3-hydroxy-3-methylglutaryl-coenzyme A reductase
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3-hydroxy-3-methylglutaryl-coenzyme A reductase
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3-hydroxy-3-methylglutaryl-coenzyme A reductase
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3-hydroxy-3-methylglutaryl-coenzyme A reductase
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3-hydroxy-3-methylglutaryl-coenzyme A reductase
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3-hydroxy-3-methylglutaryl-coenzyme A reductase
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3-hydroxy-3-methylglutaryl-coenzyme A reductase
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3-hydroxy-3-methylglutaryl-coenzyme A reductase
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HMG-CoA reductase
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HMG-CoAR
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HMG1
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HMG2
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HMGCR
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HMGR
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HMGR
Ochromonas malhamensis
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HMGR1
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HMGR1S
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HMGR2
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HMGR3
isoform
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(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
Glu559 and His866 are involved in catalysis
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(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
via mevaldehyde as an intermediate product
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(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
via mevaldehyde as an intermediate product, enzyme contains a catalytic His381, Lys267 is also involved in catalysis, active site structure
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(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
reaction mechanism, modelling of three different systems, detailed overview. Formation of a mevaldyl-CoA intermediate protonated by a conserved active site lysine, Lys691. The conserved active site glutamate and aspartate residues, Glu559 and Asp767, along with the ribose moiety of NADPH, form a hydrogen bond network crucial to the increase of the stabilizing effect of Lys691 over the transition state. A charged His752 forms an oxyanion hole with Lys691 to stabilize the negative charge developed in the thioester oxygen
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(R)-mevaldehyde + NADPH + H+
(R)-mevalonate + NADP+
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
(R)-mevalonate + CoA + NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + NADPH + H+
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(R,S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
(R)-mevalonate + CoA + 2 NADP+
(R,S)-mevaldehyde + acetate
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(R,S)-mevaldehyde + NADPH
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(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
(R)-mevalonate + 2 NADP+ + CoA
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
mevalonate + CoA + 2 NADP+
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(S)-3-hydroxy-3-methylglutaryl-CoA + NADPH + H+
mevaldehyde + CoA + NADP+
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first step reaction
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(S)-3-hydroxy-3-methylglutaryl-CoA + NADPH + H+
mevaldyl-CoA + NADP+
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
mevalonate + CoA + 2 NADP+
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
mevalonolactone + CoA + 2 NADP+ + H2O
3-hydroxy-3-methylglutaryl-CoA + NADPH
(R)-mevalonate + CoA + NADP+
3-hydroxy-3-methylglutaryl-CoA + NADPH
mevalonate + CoA + NADP+
3-hydroxy-3-methylglutaryl-CoA + NADPH + H+
mevalonate + CoA + NADP+
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acetyl-CoA
acetoacetyl-CoA + CoA
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D-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
(R)-mevalonate + CoA + 2 NADP+
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D-3-hydroxy-3-methylglutaryl-CoA + NADPH
mevalonate + CoA + NADP+
DL-3-hydroxy-3-methylglutaryl-CoA + NADPH
mevalonate + CoA + NADP+
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hydroxymethylglutaryl-CoA + NADPH + H+
mevalonate + NADP+ + CoA
mevaldehyde + NADPH + H+
(R)-mevalonate + NADP+
mevaldyl-CoA + H2O
mevaldehyde + NADP+
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second step reaction
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mevaldyl-CoA + NADPH + H+ + H2O
(R)-mevalonate + CoA + NADP+
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second step reaction
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additional information
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(R)-mevaldehyde + NADPH + H+
(R)-mevalonate + NADP+
second step of the reaction
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(R)-mevaldehyde + NADPH + H+
(R)-mevalonate + NADP+
second step of the reaction
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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r
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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r
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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r
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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r
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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r
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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r
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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r
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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r
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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r
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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r
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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(R)-mevalonate + CoA + 2 NADP+
1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
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