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IUBMB Comments The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf . EC 1.1.1.347 , geraniol dehydrogenase (NAD+ EC 1.1.1.216 , farnesol dehydrogenase (NADP+ +
Synonyms
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NAD+-farnesol dehydrogenase
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(2E,6E)-farnesol + NAD+ = (2E,6E)-farnesal + NADH + H+
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(2E,6E)-farnesol:NAD+ 1-oxidoreductase
The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC 1.1.1.347, geraniol dehydrogenase (NAD+)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor.
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(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
3-methyl-2-buten-1-ol + NAD+
3-methyl-2-butenal + NADH + H+
Substrates: 4.3% of the activity compared to geraniol
?
citronellol + NAD+
?
Substrates: 4.3% of the activity compared to geraniol
?
geraniol + NAD+
geranial + NADH + H+
geranylgeraniol + NAD+
? + NADH + H+
Substrates: -
?
additional information
?
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Substrates: straight-chain alcohols such as 1-octanol, 2-buten-1-ol, 1-butanol and ethanol serve as poor substrates
?
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
Substrates: highest affinity for the active site of the FLDH enzyme, FLDH-encoded enzyme does not exhibit appreciable farnesal reductase activity
ir
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
Substrates: key enzyme in biosynthesis of the alarm pheromone neral
?
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
Substrates: 50% of the activity compared to geraniol
?
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
-
Substrates: -
?
geraniol + NAD+
geranial + NADH + H+
Substrates: -
?
geraniol + NAD+
geranial + NADH + H+
Substrates: nerol, the geometrical isomer of geraniol is inactive. The enzyme cannot use NADP+ as cofactor
?
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(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
Substrates: key enzyme in biosynthesis of the alarm pheromone neral
?
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
-
Substrates: -
?
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NAD+
the enzyme cannot use NADP+ as cofactor
NAD+
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dependent on NAD+, cannot be replaced by NADP+
NAD+
no oxidation observed in the presence of NADP+
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0.051
geraniol
pH 8.5, 22°C
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2996
geraniol
pH 8.5, 22°C
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58400
geraniol
pH 8.5, 22°C
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8 - 10.5
pH 8.0: about 75% of maximal activity, pH 10.5: about 35% of maximal activity
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5 - 60
5°C: about 50% of maximal activity, 60°C: about 50% of maximal activity
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UniProt
brenda
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UniProt
brenda
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brenda
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brenda
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brenda
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brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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physiological function
key enzyme in biosynthesis of the alarm pheromone neral
physiological function
results suggest that FLDH is a negative regulator of ABA signaling
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B2NI94_CARLC
33
0
3579
TrEMBL
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Q9SZB3_ARATH
344
0
37861
TrEMBL
other Location (Reliability: 5 )
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40630
1 * 40630, calculated from sequence
42800
1 * 42800, SDS-PAGE
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monomer
1 * 42800, SDS-PAGE
monomer
1 * 40630, calculated from sequence
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overexpression of recombinant Arabidopsis farnesol dehydrogenase activity in Saccharomyces cerevisiae strain SM1058 using pCL196 plasmid
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expression is increased in mutants with T-DNA insertions in the FLDH 5' flanking region indicating that both T-DNA insertions disrupt a cis-acting negative regulatory element in the FLDH promoter
FLDH expression is repressed by exogenous abscisic acid and FLDH expression negatively regulates ABA signaling
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Noge, K.; Kato, M.; Mori, N.; Kataoka, M.; Tanaka, C.; Yamasue, Y.; Nishida, R.; Kuwahara, Y.
Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae)
FEBS J.
275
2807-2817
2008
Carpoglyphus lactis (B2NI94)
brenda
Bhandari, J.; Fitzpatrick, A.H.; Crowell, D.N.
Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis thaliana
Plant Physiol.
154
1116-1127
2010
Arabidopsis thaliana (Q9SZB3)
brenda
Baker, F.C.; MAuchamp, B.; Tsai, L.W.; Schooley, D.A.
Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta
J. Lipid Res.
24
1586-1594
1983
Manduca sexta
brenda
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