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Information on EC 1.1.1.391 - 3beta-hydroxycholanate 3-dehydrogenase (NAD+)

for references in articles please use BRENDA:EC1.1.1.391
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IUBMB Comments
This bacterial enzyme is involved, along with EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.393, 3beta-hydroxycholanate 3-dehydrogenase (NADP+).
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
bile acid 3beta-hsd, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
isolithocholate + NAD+ = 3-oxo-5beta-cholan-24-oate + NADH + H+
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