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Information on EC 1.1.1.399 - 2-oxoglutarate reductase

for references in articles please use BRENDA:EC1.1.1.399

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IUBMB Comments

The enzyme catalyses a reversible reaction. The enzyme from the bacterium Peptoniphilus asaccharolyticus is specific for (R)-2-hydroxyglutarate [1,2]. The SerA enzyme from the bacterium Escherichia coli can also accept (S)-2-hydroxyglutarate with a much higher Km, and also catalyses the activity of EC 1.1.1.95, phosphoglycerate dehydrogenase .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
2-oxoglutarate reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
L-glutamate degradation V (via hydroxyglutarate), L-glutamate degradation XI (reductive Stickland reaction)
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