Information on EC 1.1.1.407 - D-altritol 5-dehydrogenase

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EC Tree 1 Oxidoreductases 1.1 Acting on the CH-OH group of donors 1.1.1 With NAD⁺ or NADP⁺ as acceptor 1.1.1.407 D-altritol 5-dehydrogenase

IUBMB Comments

The enzyme, characterized in Agrobacterium fabrum C58, also has low activity with D-mannitol and D-arabinitol. It is part of a D-altritol degradation pathway.

The enzyme appears in viruses and cellular organisms

Reaction Schemes

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Synonyms
Atu3163, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Atu3163

Atu3163

Atu3163

Agrobacterium fabrum C58

A9CES3

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

D-altritol + NAD+ = D-tagatose + NADH + H+

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PATHWAY SOURCE

PATHWAYS

MetaCyc

D-altritol and galactitol degradation

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SYSTEMATIC NAME

IUBMB Comments

D-altritol:NAD+ 5-oxidoreductase

The enzyme, characterized in Agrobacterium fabrum C58, also has low activity with D-mannitol and D-arabinitol. It is part of a D-altritol degradation pathway.

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

D-altritol + NAD+

D-tagatose + NADH + H+

2 entries

D-arabitol + NAD+

? + NADH + H+

2 entries

D-mannitol + NAD+

? + NADH + H+

2 entries

additional information

2 entries

D-altritol + NAD+

D-tagatose + NADH + H+

Agrobacterium fabrum

A9CES3

740741

Substrates: -
Products: -

D-altritol + NAD+

D-tagatose + NADH + H+

Agrobacterium fabrum C58

A9CES3

740741

Substrates: -
Products: -

D-arabitol + NAD+

? + NADH + H+

Agrobacterium fabrum

A9CES3

740741

Substrates: -
Products: -

D-arabitol + NAD+

? + NADH + H+

Agrobacterium fabrum C58

A9CES3

740741

Substrates: -
Products: -

D-mannitol + NAD+

? + NADH + H+

Agrobacterium fabrum

A9CES3

740741

Substrates: -
Products: -

D-mannitol + NAD+

? + NADH + H+

Agrobacterium fabrum C58

A9CES3

740741

Substrates: -
Products: -

additional information

Agrobacterium fabrum

A9CES3

740741

Substrates: D-altritol is oxidized at a significantly greater rate than D-mannitol and D-arabitol
Products: -

additional information

Agrobacterium fabrum C58

A9CES3

740741

Substrates: D-altritol is oxidized at a significantly greater rate than D-mannitol and D-arabitol
Products: -

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

D-altritol + NAD+

D-tagatose + NADH + H+

2 entries

D-altritol + NAD+

D-tagatose + NADH + H+

Agrobacterium fabrum

A9CES3

740741

Substrates: -
Products: -

D-altritol + NAD+

D-tagatose + NADH + H+

Agrobacterium fabrum C58

A9CES3

740741

Substrates: -
Products: -

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METALS and IONS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Zn2+

Agrobacterium fabrum

A9CES3

enzyme is a zinc-binding dehydrogenase, member of Pfam Family PF00107

740741

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1.4

D-altritol

pH 9.0, 25°C

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1.9

D-altritol

pH 9.0, 25°C

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1.4

D-altritol

pH 9.0, 25°C

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Agrobacterium fabrum

740741

A9CES3

UniProt

brenda

Agrobacterium fabrum C58

740741

A9CES3

UniProt

brenda

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Highest Expressing Human Cell Lines

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Cell Line Links

Gene Links

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

A9CES3 pBLAST

ATRDH_AGRFC

Agrobacterium fabrum (strain C58 / ATCC 33970)

336

35186

Swiss-Prot

Show Sequence

A0A546XMA1 pBLAST

A0A546XMA1_RHIRD

Rhizobium radiobacter

336

35061

TrEMBL

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A0A4D7YX64 pBLAST

A0A4D7YX64_RHIRD

Rhizobium radiobacter

336

35092

TrEMBL

Show Sequence

A0A4U6AMM0 pBLAST

A0A4U6AMM0_9HYPH

Agrobacterium sp. LC34

336

35030

TrEMBL

Show Sequence

A0A846LEJ9 pBLAST

A0A846LEJ9_9HYPH

Agrobacterium sp. NCIB 9042

336

35169

TrEMBL

Show Sequence

A0A8F8NEA7 pBLAST

A0A8F8NEA7_9HYPH

Agrobacterium sp. S7/73

336

34972

TrEMBL

Show Sequence

A0A4Z1Q790 pBLAST

A0A4Z1Q790_RHIRD

Rhizobium radiobacter

336

34967

TrEMBL

Show Sequence

A0A546YYA4 pBLAST

A0A546YYA4_RHIRD

Rhizobium radiobacter

336

34925

TrEMBL

Show Sequence

A0A7L5BLJ1 pBLAST

A0A7L5BLJ1_9HYPH

Rhizobium oryzihabitans

336

35043

TrEMBL

Show Sequence

A0A3S2XAQ8 pBLAST

A0A3S2XAQ8_9HYPH

Agrobacterium sp. CNPSo 2736

336

35075

TrEMBL

Show Sequence

A0A4Z1QPG0 pBLAST

A0A4Z1QPG0_9HYPH

Agrobacterium salinitolerans

336

34872

TrEMBL

Show Sequence

A0A8A5PHC4 pBLAST

A0A8A5PHC4_RHIRD

Rhizobium radiobacter

336

34971

TrEMBL

Show Sequence

A0A546X9M2 pBLAST

A0A546X9M2_AGRRH

Agrobacterium rhizogenes

336

35074

TrEMBL

Show Sequence

A0A7I0RPP8 pBLAST

A0A7I0RPP8_9HYPH

Agrobacterium sp. CGMCC 11546

336

35113

TrEMBL

Show Sequence

A0A5D9CUV2 pBLAST

A0A5D9CUV2_9HYPH

Agrobacterium sp. B1(2019)

336

35125

TrEMBL

Show Sequence

A0A4D7Y0A8 pBLAST

A0A4D7Y0A8_RHIRD

Rhizobium radiobacter

336

35030

TrEMBL

Show Sequence

A0A5B8K8M0 pBLAST

A0A5B8K8M0_RHIRD

Rhizobium radiobacter

336

35172

TrEMBL

Show Sequence

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

740741

Wichelecki, D.; Vetting, M.; Chou, L.; Al-Obaidi, N.; Bouvier, J.; Almo, S.; Gerlt, J.

ATP-binding cassette (ABC) transport system solute-binding protein-guided identification of novel D-altritol and galactitol catabolic pathways in Agrobacterium tumefaciens C58

J. Biol. Chem.

290

28963-28976

2015

Agrobacterium fabrum (A9CES3), Agrobacterium fabrum C58 (A9CES3)

26472925

brenda

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EXTERNAL LINKS (specific for EC-Number 1.1.1.407)

ExplorEnz (official portal for IUBMB Enzyme Nomenclature)

Expasy Enzyme Nomenclature Database

KEGG

SABIO-RK

NCBI: PubMed, Protein, Nucleotide, Structure, Gene, OMIM

Enzyme Nomenclature (alternative site)

UniProt

PDB

PROSITE Database of protein families and domains

InterPro (database of protein families, domains and functional sites)

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