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Information on EC 1.1.1.41 - isocitrate dehydrogenase (NAD+)

for references in articles please use BRENDA:EC1.1.1.41

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IUBMB Comments

Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.42, isocitrate dehydrogenase (NADP+), oxalosuccinate cannot be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm . The enzyme from some species can also use NADP+ but much more slowly .

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
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isocitrate
+
NAD+
=
2-oxoglutarate
+
CO2
+
NADH
+
H+
+
=
+
+
+

Synonyms
isocitrate dehydrogenase, isocitrate dehydrogenase 2, isocitric dehydrogenase, nad-dependent isocitrate dehydrogenase, idh3a, nad-idh, nad-isocitrate dehydrogenase, nad-icdh, nad+-dependent isocitrate dehydrogenase, nad-linked isocitrate dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
nitrogen remobilization from senescing leaves, TCA cycle II (plants and fungi), TCA cycle III (animals)
Highest Expressing Human Cell Lines
Cell Line Links Gene Links