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IUBMB CommentsThe enzyme, characterized from bacteria, is involved in D-erythronate catabolism.
The enzyme appears in viruses and cellular organisms
Synonyms
D-erythronate 2-dehydrogenase, denD, more
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D-erythronate 2-dehydrogenase
D-erythronate 2-dehydrogenase

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D-erythronate 2-dehydrogenase
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denD

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D-erythronate + NAD+ = 2-dehydro-D-erythronate + NADH + H+
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MetaCyc
D-erythronate degradation II
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D-erythronate:NAD+ 2-oxidoreductase
The enzyme, characterized from bacteria, is involved in D-erythronate catabolism.
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D-erythronate + NAD+
2-dehydro-D-erythronate + NADH + H+
D-erythronate + NADP+
2-dehydro-D-erythronate + NADPH + H+
D-erythronate + NAD+

2-dehydro-D-erythronate + NADH + H+
Substrates: -
Products: -
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D-erythronate + NAD+
2-dehydro-D-erythronate + NADH + H+
Substrates: -
Products: -
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D-erythronate + NADP+

2-dehydro-D-erythronate + NADPH + H+
Substrates: -
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D-erythronate + NADP+
2-dehydro-D-erythronate + NADPH + H+
Substrates: -
Products: -
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NAD+
NAD+ is preferred over NADP+
NADP+
NAD+ is preferred over NADP+
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0.59
D-erythronate

cosubstrate NAD+, pH 8.0, 25°C
2.4
D-erythronate
cosubstrate NADP+, pH 8.0, 25°C
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3
D-erythronate

cosubstrate NADP+, pH 8.0, 25°C
19
D-erythronate
cosubstrate NAD+, pH 8.0, 25°C
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1.2
D-erythronate

cosubstrate NADP+, pH 8.0, 25°C
33
D-erythronate
cosubstrate NAD+, pH 8.0, 25°C
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UniProt
brenda
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UniProt
brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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DEND_HAEIN
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
315
0
35145
Swiss-Prot
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DEND_CUPNH
Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)
324
0
34270
Swiss-Prot
other Location (Reliability: 1)
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Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.
Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars
Proc. Natl. Acad. Sci. USA
113
E4161-E4169
2016
Cupriavidus necator (Q0KBD2), Cupriavidus necator DSM 428 (Q0KBD2)
brenda
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