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Information on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+)

for references in articles please use BRENDA:EC1.1.1.42

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IUBMB Comments

Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+), oxalosuccinate can be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm . The enzyme from some species can also use NAD+ but much more slowly [6,7].

The enzyme appears in viruses and cellular organisms
Reaction Schemes
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isocitrate
+
NADP+
=
2-oxoglutarate
+
CO2
+
NADPH
+
H+
+
=
+
+
+

Synonyms
isocitrate dehydrogenase 1, nadp-isocitrate dehydrogenase, nadp-dependent isocitrate dehydrogenase, isocitrate dehydrogenase-1, nadp-icdh, nadp-idh, nadp+-dependent isocitrate dehydrogenase, nadp-linked isocitrate dehydrogenase, nadp-specific isocitrate dehydrogenase, nadp+-specific isocitrate dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+
show the reaction diagram
isocitrate + NADP+ = oxalosuccinate + NADPH + H+
show the reaction diagram
(1a)
-
-
-
oxalosuccinate = 2-oxoglutarate + CO2
show the reaction diagram
(1b)
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
cytosolic NADPH production (yeast), ethene biosynthesis V (engineered), methylaspartate cycle, mixed acid fermentation, nitrogen remobilization from senescing leaves, partial TCA cycle (obligate autotrophs), reductive TCA cycle I, TCA cycle I (prokaryotic), TCA cycle IV (2-oxoglutarate decarboxylase), TCA cycle V (2-oxoglutarate synthase), TCA cycle VI (Helicobacter), TCA cycle VII (acetate-producers)