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Information on EC 1.1.1.50 - 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

for references in articles please use BRENDA:EC1.1.1.50

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IUBMB Comments

The enzyme acts on androsterone and other 3α-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. Si-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.213, 3α-hydroxysteroid 3-dehydrogenase (Re-specific).

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
3 alpha-hydroxysteroid dehydrogenase, akr1c, hydroxyprostaglandin dehydrogenase, akr1c1-4, type i 3alpha-hsd, ps3alphahsd, bile-acid binding protein, 3alpha-hydroxysteroid dehydrogenase type 3, 3-alpha-hsd, 3alpha-oxidoreductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
testosterone and androsterone degradation to androstendione (aerobic)