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Information on EC 1.1.1.8 - glycerol-3-phosphate dehydrogenase (NAD+)
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EC Tree
1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)IUBMB Comments
Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity).
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Word Map
- 1.1.1.8
- adipose
- adipocytes
- dhap
-
preadipocytes
-
alpha-gpdh
-
3-phosphatase
-
phosphodianion
-
fad-linked
- synthesis
- food industry
- nutrition
- medicine
- biotechnology
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
glycerol 3-phosphate dehydrogenase, mgpdh, gpdh-1, glycerol-3-phosphate dehydrogenase 1, gpd1p, g3p dehydrogenase, cgpdh, gpdh-2, cggpd, alpha glycerophosphate dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
(NAD+)-dependent G3pdh
(NAD+)-dependent glycerol-3-phosphate dehydrogenase
alpha-glycerol phosphate dehydrogenase (NAD)
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alpha-glycerophosphate dehydrogenase (NAD)
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Cagpd1
Cagpd2
cGPdH
cytoplasmic NAD-dependent glycerol-3-phosphate dehydrogenase
dehydrogenase, glycerol phosphate
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DhGPD1
G3PD1
G3PD2
G3PD3
G3PDH
glycerol 1-phosphate dehydrogenase
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glycerol 3-phosphate dehydrogenase
glycerol phosphate dehydrogenase (NAD)
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glycerol-3-phosphate dehydrogenase
glycerol-3-phosphate dehydrogenase 1
glycerophosphate dehydrogenase (NAD)
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GPD
GPD1
Gpd1p
gpd2p
GPDH
GPDH-1
GPDH-2
GPDH1
GPDH2
GPDH3
GPDH: NAD+ 2 oxidorreductase
hydroglycerophosphate dehydrogenase
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L-alpha-glycerol phosphate dehydrogenase
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L-alpha-glycerophosphate dehydrogenase
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L-glycerol phosphate dehydrogenase
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L-glycerophosphate dehydrogenase
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mGPDH
NAD+-dependent G3P dehydrogenase
NAD+-dependent glycerol-3-phosphate dehydrogenase
NAD+-GPDH
NAD-alpha-glycerophosphate dehydrogenase
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NAD-dependent glycerol phosphate dehydrogenase
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NAD-dependent glycerol-3-phosphate dehydrogenase
NAD-L-glycerol-3-phosphate dehydrogenase
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NAD-linked glycerol 3-phosphate dehydrogenase
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NADH-dihydroxyacetone phosphate reductase
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NADP+-dependent glycerol 3-phosphate dehydrogenase
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GPDH-2
isozyme GPDH-2 provides precursors for lipid biosynthesis in many tissues
GPDH1
isozyme, contains an extra phosphoserine phosphatase domain at the N-terminus in addition to C-terminal GPDH domains
GPDH1
isozyme, contains an extra phosphoserine phosphatase domain at the N-terminus in addition to C-terminal GPDH domains
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GPDH2
isozyme, contains an extra phosphoserine phosphatase domain at the N-terminus in addition to C-terminal GPDH domains
GPDH2
isozyme, contains an extra phosphoserine phosphatase domain at the N-terminus in addition to C-terminal GPDH domains
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NAD-dependent glycerol-3-phosphate dehydrogenase
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-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor
ordered bi-bi mechanism
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sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor
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sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+
ordered bi-bi mechanism
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sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+
one active site per enzyme molecule
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sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+
one active site per enzyme molecule
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sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+
one active site per enzyme molecule
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sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+
ordered ternary-complex mechanism, NADH binds first
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sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+
equilibrium random-bi-bi reaction mechanism
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sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+
equilibrium random-bi-bi reaction mechanism
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sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+
equilibrium random-bi-bi reaction mechanism
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sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+
equilibrium random-bi-bi reaction mechanism
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sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase
Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity).
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CAS REGISTRY NUMBER
COMMENTARY
9075-65-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dihydroxyacetone phosphate + NADH + H+
NAD+ + sn-glycerol 3-phosphate
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 1-phosphate + NAD+
-
-
-
r
dihydroxyacetone phosphate + NADH
glycerol-3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH
sn-glycerol 3-phosphate + NAD+
an electrophilic catalytic mechanism by the epsilon-NH3+ group of Lys204 is proposed on the basis of the structural analysis
-
-
?
dihydroxyacetone phosphate + NADH
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
r
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
r
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
r
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
?
dihydroxyacetone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
?
glycerone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
r
glycerone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
?
glycerone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
?
glycerone phosphate + NADH + H+
sn-glycerol 3-phosphate + NAD+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
oxidation at 25% the rate of dihydroxyacetone phosphate reduction at optimal pH
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r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
isozymes GPDH1 can utilize both NADH and NADPH as coenzymes but exhibits significantly higher activities when NADH is used as the coenzyme
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-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
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-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
isozymes GPDH1 can utilize both NADH and NADPH as coenzymes but exhibits significantly higher activities when NADH is used as the coenzyme
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-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
equilibrium far to the side of alpha-glycerophosphate at neutral pH
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
mGPDH is involved in maintaining a high rate of glycolysis and is an important site of electron leakage leading to production of reactive oxygen species in prostate cancer cells
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-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
equilibrium far to the side of alpha-glycerophosphate at neutral pH
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
favoured reaction of heart isozyme II6.1
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
equilibrium far to the side of alpha-glycerophosphate at neutral pH
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
oxidation at 3% the reaction rate of dihydroxyacetone phosphate reduction at pH 7.0
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
reverse reaction favoured direction
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
oxidation at 3% the reaction rate of dihydroxyacetone phosphate reduction at pH 7.0
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
oxidation at 25% the rate of dihydroxyacetone phosphate reduction at optimal pH
-
r
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+
-
-
-
?
sn-glycerol 3-phosphate + NAD+
dihydroxyacetone phosphate + NADH + H+