Disease on EC 1.1.1.B40 - 11beta-hydroxysteroid dehydrogenase (NAD+)
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11beta-hydroxysteroid dehydrogenase (nad+) deficiency
11 beta-Hydroxysteroid dehydrogenase deficiency and glucocorticoid status in patients with alcoholic and non-alcoholic chronic liver disease.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Abnormalities of aldosterone synthesis and action in children.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Apparent mineralocorticoid excess due to 11 beta-hydroxysteroid dehydrogenase deficiency: a possible cause of intrauterine growth retardation.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Cellular selectivity of aldosterone action: role of 11 beta-hydroxysteroid dehydrogenase.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Congenital 11 beta-hydroxysteroid dehydrogenase deficiency associated with juvenile hypertension: corticosteroid metabolite profiles of four patients and their families.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Fatal, low renin hypertension associated with a disturbance of cortisol metabolism.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Glucocorticoids and blood pressure: a role for the cortisol/cortisone shuttle in the control of vascular tone in man.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Heterogeneity of urinary steroid profiles in children with adrenocortical tumors.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Impaired 11-beta hydroxysteroid dehydrogenase type 2 activity in sweat gland ducts in human essential hypertension.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Mineralocorticoid hypertension and congenital deficiency of 11 beta-hydroxysteroid dehydrogenase in a family with the syndrome of 'apparent' mineralocorticoid excess.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Renin-Independent hypermineralocorticoidism.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Spironolactone-reversible rickets associated with 11 beta-hydroxysteroid dehydrogenase deficiency syndrome.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
[11 beta-Hydroxysteroid dehydrogenase deficiency]
11beta-hydroxysteroid dehydrogenase deficiency
Defects in the HSD11 gene encoding 11 beta-hydroxysteroid dehydrogenase are not found in patients with apparent mineralocorticoid excess or 11-oxoreductase deficiency.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Apparent cortisone reductase deficiency: a rare cause of hyperandrogenemia and hypercortisolism.
ACTH Syndrome, Ectopic
Mineralocorticoid excess and inhibition of 11 beta-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome.
ACTH Syndrome, Ectopic
Regulation of the 11 beta-hydroxysteroid dehydrogenase in the rat adrenal. Decrease enzymatic activity induced by ACTH.
Adenoma
Cortisol-secreting adrenal adenomas express 11beta-hydroxysteroid dehydrogenase type-2 gene yet possess low 11beta-HSD2 activity.
Adenoma
Role of local 11 beta-hydroxysteroid dehydrogenase type 2 expression in determining the phenotype of adrenal adenomas.
Adrenal Hyperplasia, Congenital
Effect of hypercortisolism and ACTH on the metabolism of cortisol.
Alkalosis
Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess.
Alkalosis
Regulation of the 11 beta-hydroxysteroid dehydrogenase in the rat adrenal. Decrease enzymatic activity induced by ACTH.
Asthma
A novel 11 beta-hydroxysteroid dehydrogenase inhibitor contained in saiboku-to, a herbal remedy for steroid-dependent bronchial asthma.
Breast Neoplasms
Inhibition of 11 beta-hydroxysteroid dehydrogenase activity enhances the antiproliferative effect of glucocorticosteroids on MCF-7 and ZR-75-1 breast cancer cells.
Carcinoma
Expression of 11 beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor in primary lung carcinomas.
Cardiomegaly
Early inflammatory responses in experimental cardiac hypertrophy and fibrosis: effects of 11 beta-hydroxysteroid dehydrogenase inactivation.
Cholestasis
Reduced activity of 11 beta-hydroxysteroid dehydrogenase in patients with cholestasis.
Choriocarcinoma
Analysis of the promoter of the NAD+ dependent 11 beta-hydroxysteroid dehydrogenase (HSD11K) gene in JEG-3 human choriocarcinoma cells.
Choriocarcinoma
Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells.
Cushing Syndrome
11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome.
Cushing Syndrome
Human kidney 11 beta-hydroxysteroid dehydrogenase: regulation by adrenocorticotropin?
Cushing Syndrome
[Decreased activity of 11-beta-hydroxysteroid dehydrogenase in patients with Cushing's syndrome]
Diabetes Mellitus
Evaluation of hepatic 11 beta-hydroxysteroid dehydrogenase activity by cortisone acetate test in young adults with diabetes mellitus type 1.
Diabetes Mellitus, Type 2
Decreased expression of adipogenic genes in obese subjects with type 2 diabetes.
Diabetes Mellitus, Type 2
Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes.
Endometrial Neoplasms
Modulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity in Ishikawa cells is associated with changes in cellular proliferation.
Essential Hypertension
11beta-hydroxysteroid dehydrogenase type-2 and type-1 (11beta-HSD2 and 11beta-HSD1) and 5beta-reductase activities in the pathogenia of essential hypertension.
Essential Hypertension
Corticosteroids in essential hypertension: multiple candidate loci and phenotypic variation.
Essential Hypertension
Deficient inactivation of cortisol by 11 beta-hydroxysteroid dehydrogenase in essential hypertension.
Essential Hypertension
Endogenous renal 11 beta-hydroxysteroid dehydrogenase inhibitory factors in patients with low-renin essential hypertension.
Essential Hypertension
Evidence of coexisting changes in 11 beta-hydroxysteroid dehydrogenase and 5 beta-reductase activity in subjects with untreated essential hypertension.
Essential Hypertension
Genetic association of 11 beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) flanking microsatellites with essential hypertension in blacks.
Essential Hypertension
Impaired 11-beta hydroxysteroid dehydrogenase type 2 activity in sweat gland ducts in human essential hypertension.
Essential Hypertension
Organ-specific actions of 11 beta-hydroxysteroid dehydrogenase in humans: implications for the pathophysiology of hypertension.
Essential Hypertension
The activities of 5 beta-reductase and 11 beta-hydroxysteroid dehydrogenase in essential hypertension.
Fetal Growth Retardation
Apparent mineralocorticoid excess due to 11 beta-hydroxysteroid dehydrogenase deficiency: a possible cause of intrauterine growth retardation.
Genetic Diseases, Inborn
Apparent mineralocorticoid excess and the long term treatment of genetic hypertension.
Genetic Diseases, Inborn
Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess.
Heart Failure
Glucocorticoid metabolism and the action of 11 beta-hydroxysteroid dehydrogenase 2 in canine congestive heart failure.
Heart Failure
Inhibitors of 11 beta-hydroxysteroid dehydrogenase and 5 beta-steroid reductase in urine from patients with congestive heart failure.
Hyperandrogenism
5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activity in prepubertal Hispanic girls with premature adrenarche.
Hyperandrogenism
Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11 beta-hydroxysteroid dehydrogenase.
Hypertension
11 beta-hydroxysteroid dehydrogenase (11 beta-HSD-II) activity in human placenta: its relationship to placental weight and birth weight and its possible role in hypertension.
Hypertension
11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome.
Hypertension
11 beta-Hydroxysteroid dehydrogenase activity in hypertension and renal disease.
Hypertension
11 beta-Hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess.
Hypertension
11 beta-Hydroxysteroid dehydrogenase deficit: a rare cause of arterial Hypertension. Diagnosis and therapeutic approach in two young brothers.
Hypertension
11 beta-Hydroxysteroid dehydrogenase: a link between the dysregulation of cortisol metabolism and hypertension.
Hypertension
A new compound heterozygous mutation in the 11 beta-hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess.
Hypertension
Apparent mineralocorticoid excess and the long term treatment of genetic hypertension.
Hypertension
Association between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension.
Hypertension
Congenital 11 beta-hydroxysteroid dehydrogenase deficiency associated with juvenile hypertension: corticosteroid metabolite profiles of four patients and their families.
Hypertension
Cortisol metabolism in hypertensive patients who do and do not develop hypokalemia from diuretics.
Hypertension
Cortisol, hypertension and obesity: the role of 11 beta-hydroxysteroid dehydrogenase.
Hypertension
Decreased activity of 11 beta-hydroxysteroid dehydrogenase in mesenteric arteries of Dahl salt-sensitive rats.
Hypertension
Defects in the HSD11 gene encoding 11 beta-hydroxysteroid dehydrogenase are not found in patients with apparent mineralocorticoid excess or 11-oxoreductase deficiency.
Hypertension
Effect of carbenoxolone on glucocorticoid metabolism and Na transport in toad bladder.
Hypertension
Endogenous 11 beta-hydroxysteroid dehydrogenase inhibitors and their role in glucocorticoid Na+ retention and hypertension.
Hypertension
Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension.
Hypertension
Evidence of coexisting changes in 11 beta-hydroxysteroid dehydrogenase and 5 beta-reductase activity in subjects with untreated essential hypertension.
Hypertension
Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess.
Hypertension
Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11{beta}-hydroxysteroid dehydrogenase type 2 in a sex-specific manner.
Hypertension
Glucocorticoids and blood pressure: a role for the cortisol/cortisone shuttle in the control of vascular tone in man.
Hypertension
Haemodynamic and metabolic effects of carbenoxolone in normal subjects and patients with renal impairment.
Hypertension
Human hypertension caused by mutations in the 11 beta-hydroxysteroid dehydrogenase gene: a molecular analysis of apparent mineralocorticoid excess.
Hypertension
Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase.
Hypertension
Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11 beta-hydroxysteroid dehydrogenase type 2 gene.
Hypertension
Insulin, CCAAT/enhancer-binding proteins and lactate regulate the human 11?-hydroxysteroid dehydrogenase type 2 gene expression in colon cancer cell lines.
Hypertension
Investigation of the mechanism of hypertension in apparent mineralocorticoid excess.
Hypertension
Mineralocorticoid hypertension and congenital deficiency of 11 beta-hydroxysteroid dehydrogenase in a family with the syndrome of 'apparent' mineralocorticoid excess.
Hypertension
Molecular analysis of 11 beta-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess.
Hypertension
Mutations in the 11 beta-hydroxysteroid dehydrogenase type II enzyme associated with hypertension and possibly stillbirth.
Hypertension
Organ-specific actions of 11 beta-hydroxysteroid dehydrogenase in humans: implications for the pathophysiology of hypertension.
Hypertension
Placental 11 beta-hydroxysteroid dehydrogenase activity in normotensive and pre-eclamptic pregnancies.
Hypertension
Placental 11 beta-hydroxysteroid dehydrogenase and the programming of hypertension.
Hypertension
Regulation of the 11 beta-hydroxysteroid dehydrogenase in the rat adrenal. Decrease enzymatic activity induced by ACTH.
Hypertension
Sodium status, corticosteroid metabolism and blood pressure in normal human subjects and in a patient with abnormal salt appetite.
Hypertension
The 11 beta-OHSD inhibitor, carbenoxolone, enhances Na retention by aldosterone and 11-deoxycorticosterone.
Hypertension
The maternal diet during pregnancy programs altered expression of the glucocorticoid receptor and type 2 11beta-hydroxysteroid dehydrogenase: potential molecular mechanisms underlying the programming of hypertension in utero.
Hypertension
The role of 11 beta-hydroxysteroid dehydrogenase in the pathogenesis of hypertension.
Hypertension
Urinary free cortisone and the assessment of 11 beta-hydroxysteroid dehydrogenase activity in man.
Hypertension
[11 beta-hydroxysteroid dehydrogenase type 2 activity in Chilean patients with hypertension]
Hypertension
[Aldosterone and 11 beta-hydroxysteroid dehydrogenase: role in arterial hypertension]
Hypoaldosteronism
Apparent mineralocorticoid excess and the long term treatment of genetic hypertension.
Hypoaldosteronism
Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess.
Hypokalemia
A new compound heterozygous mutation in the 11 beta-hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess.
Hypokalemia
Apparent mineralocorticoid excess and the long term treatment of genetic hypertension.
Hypokalemia
Cortisol metabolism in hypertensive patients who do and do not develop hypokalemia from diuretics.
Hypokalemia
Inhibition of 11 beta-hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds.
Infections
Active catabolism of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase in vivo is a necessary requirement for natural resistance to infection with Listeria monocytogenes.
Infertility
11 beta-Hydroxysteroid dehydrogenase enzyme activity in granulosa cells derived from ovarian follicles of in vitro fertilization patients.
Inflammatory Bowel Diseases
The Role and Regulation of the 11 Beta-Hydroxysteroid Dehydrogenase Enzyme System in Patients with Inflammatory Bowel Disease.
Insulin Resistance
Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes.
Insulin Resistance
Subcutaneous abdominal adipose tissue subcompartments: potential role in rosiglitazone effects.
Insulin Resistance
The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue.
Leukemia
Meeting Report:The 7th ESPE Growth Plate Working Group Symposium - EUROGROP June 27th 2007, Helsinki, Finland.
Liddle Syndrome
Down-regulation of a hepatic transporter multidrug resistance-associated protein 2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury.
Liver Cirrhosis
Down-regulation of hepatic and renal 11 beta-hydroxysteroid dehydrogenase in rats with liver cirrhosis.
Liver Cirrhosis
Increased apical targeting of renal epithelial sodium channel subunits and decreased expression of type 2 11beta-hydroxysteroid dehydrogenase in rats with CCl4-induced decompensated liver cirrhosis.
Liver Diseases
11 beta-Hydroxysteroid dehydrogenase deficiency and glucocorticoid status in patients with alcoholic and non-alcoholic chronic liver disease.
Metabolic Syndrome
Global 11 Beta-Hydroxysteroid Dehydrogenase Activity Assessed by the Circulating Cortisol to Cortisone Ratio is Associated with Features of Metabolic Syndrome.
Mineralocorticoid Excess Syndrome, Apparent
Central hypertensinogenic effects of glycyrrhizic acid and carbenoxolone.
Mineralocorticoid Excess Syndrome, Apparent
[Liquorice-induced hypertension and hypokalaemia].
Neoplasms
11 beta-hydroxysteroid dehydrogenase type II in human colon: a new marker of fetal development and differentiation in neoplasms.
Neoplasms
Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPAR? Regulation in Hyperlipidemic and Hypertensive Conditions.
Neoplasms
Presence of 11 beta-hydroxysteroid dehydrogenase enzyme in the human prostate tumor cell line LNCaP.
Obesity
Cortisol, hypertension and obesity: the role of 11 beta-hydroxysteroid dehydrogenase.
Obesity
Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11 beta-hydroxysteroid dehydrogenase.
Obesity, Abdominal
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.
Obesity, Abdominal
Omental adipose tissue type 1 11 beta-hydroxysteroid dehydrogenase oxoreductase activity, body fat distribution, and metabolic alterations in women.
Obesity, Abdominal
The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
Osteoporosis
The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
Osteosarcoma
Characterization of 11beta-hydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines.
Ovarian Neoplasms
Type 2 11beta-hydroxysteroid dehydrogenase activity in human ovarian cancer.
Pituitary Neoplasms
Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation.
Pituitary Neoplasms
Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors.
Polycystic Ovary Syndrome
5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activity in prepubertal Hispanic girls with premature adrenarche.
Polycystic Ovary Syndrome
Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11 beta-hydroxysteroid dehydrogenase.
Pre-Eclampsia
11 beta-Hydroxysteroid dehydrogenase and its inhibitors in hypertensive pregnancy.
Prostatic Neoplasms
11 beta-Hydroxysteroid dehydrogenase and tissue specificity of androgen action in human prostate cancer cell LNCaP.
Respiratory Distress Syndrome
Increased expression of 11 beta-hydroxysteroid dehydrogenase type 2 in the lungs of patients with acute respiratory distress syndrome.
Rickets
Spironolactone-reversible rickets associated with 11 beta-hydroxysteroid dehydrogenase deficiency syndrome.
Stillbirth
Mutations in the 11 beta-hydroxysteroid dehydrogenase type II enzyme associated with hypertension and possibly stillbirth.
Vaccinia
Expression of 11 beta-hydroxysteroid dehydrogenase using recombinant vaccinia virus.
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