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Disease on EC 1.1.2.2 - mannitol dehydrogenase (cytochrome)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Metadherin confers chemoresistance of cervical cancer cells by inducing autophagy and activating ERK/NF-?B pathway.
MiR-1297 suppresses pancreatic cancer cell proliferation and metastasis by targeting MTDH.
MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma.
Adenoma
Downregulation of miR-375 in aldosterone-producing adenomas promotes tumour cell growth via MTDH.
Brain Diseases
AEG-1 Regulates TWIK-1 Expression as an RNA-Binding Protein in Astrocytes.
Breast Neoplasms
A novel metadherin?7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NF?B-SIRT3 axis.
A polysaccharide from Huaier induced apoptosis in MCF-7 breast cancer cells via down-regulation of MTDH protein.
A Preliminary Study on Metadherin as a Potential Marker for Progression of Diffuse Large B Cell Lymphoma.
AMPK inhibits MTDH expression via GSK3? and SIRT1 activation: potential role in triple negative breast cancer cell proliferation.
Association of MTDH immunohistochemical expression with metastasis and prognosis in female reproduction malignancies: a systematic review and meta-analysis.
Berberine Inhibits Proliferative Ability of Breast Cancer Cells by Reducing Metadherin.
Efficient and tumor-specific knockdown of MTDH gene attenuates paclitaxel resistance of breast cancer cells both in vivo and in vitro.
Elevated expression of MTDH predicts better prognosis of locally advanced HER-2 positive breast cancer patients receiving neoadjuvant chemotherapy plus trastuzumab.
Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer.
Establishment and Characterization of MTDH Knockdown by Artificial MicroRNA Interference - Functions as a Potential Tumor Suppressor in Breast Cancer.
Expression of MTDH and IL-10 Is an Independent Predictor of Worse Prognosis in ER-Negative or PR-Negative Breast Cancer Patients.
Gene expression profiling of the 8q22-24 position in human breast cancer: TSPYL5, MTDH, ATAD2 and CCNE2 genes are implicated in oncogenesis, while WISP1 and EXT1 genes may predict a risk of metastasis.
Identification of novel variants of metadherin in breast cancer.
Identification of Staphylococcal nuclease domain containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions.
Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue.
Inhibition of metadherin sensitizes breast cancer cells to AZD6244.
Knockdown of long noncoding RNA TP73-AS1 suppresses the malignant progression of breast cancer cells in vitro through targeting miRNA-125a-3p/metadherin axis.
Knockdown of metadherin inhibits angiogenesis in breast cancer.
Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment.
Lobaplatin inhibits breast cancer progression, cell proliferation while it induces cell apoptosis by downregulating MTDH expression.
Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition.
MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin.
MicroRNA-320a inhibits breast cancer metastasis by targeting metadherin.
MicroRNA-876 is sponged by long noncoding RNA LINC00707 and directly targets metadherin to inhibit breast cancer malignancy.
MiR-153 inhibits epithelial-mesenchymal transition by targeting metadherin in human breast cancer.
MiR-26a inhibits proliferation and migration of breast cancer through repression of MCL-1.
Molecular Modification of Metadherin/MTDH Impacts the Sensitivity of Breast Cancer to Doxorubicin.
MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer.
MTDH mediates estrogen-independent growth and tamoxifen resistance by down-regulating PTEN in MCF-7 breast cancer cells.
MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NF?B-dependent pathway.
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.
Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer.
Pathologically Decreased MiR-26a Antagonizes Apoptosis and Facilitates Carcinogenesis by targeting MTDH and EZH2 in Breast Cancer.
Phenethyl Isothiocyanate Suppresses Stemness in the Chemo- and Radio-Resistant Triple-Negative Breast Cancer Cell Line MDA-MB-231/IR Via Downregulation of Metadherin.
Post-trimodality expression levels of metadherin (MTDH) as a prognostic biomarker for esophageal adenocarcinoma patients.
Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer.
Structural insights into the tumor-promoting function of the MTDH-SND1 complex.
SU6668 suppresses proliferation of triple negative breast cancer cells through down-regulating MTDH expression.
The Antitumor Effect of Metformin Is Mediated by miR-26a in Breast Cancer.
The FBXW7 tumor suppressor inhibits breast cancer proliferation and promotes apoptosis by targeting MTDH for degradation.
The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility.
The Oncogene Metadherin Modulates the Apoptotic Pathway Based on the Tumor Necrosis Factor Superfamily Member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in Breast Cancer.
Ultrasound-Targeted Microbubble Destruction (UTMD) Combined with Liposome Increases the Effectiveness of Suppressing Proliferation, Migration, Invasion, and Epithelial- Mesenchymal Transition (EMT) via Targeting Metadherin (MTDH) by ShRNA.
[Expression and clinical significance of MTDH and VEGF in triple-negative breast cancer].
Breast Neoplasms, Male
Oncogene amplification in male breast cancer: analysis by multiplex ligation-dependent probe amplification.
Carcinogenesis
Gene expression profiling of the 8q22-24 position in human breast cancer: TSPYL5, MTDH, ATAD2 and CCNE2 genes are implicated in oncogenesis, while WISP1 and EXT1 genes may predict a risk of metastasis.
Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue.
Metadherin Expression is Associated with Extrathyroidal Extension in Papillary Thyroid Cancer Patients.
Metadherin/Astrocyte elevated gene-1 positively regulates the stability and function of forkhead box M1 during tumorigenesis.
Metadherin: An emerging key regulator of the malignant progression of multiple cancers.
MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma.
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.
Pathologically Decreased MiR-26a Antagonizes Apoptosis and Facilitates Carcinogenesis by targeting MTDH and EZH2 in Breast Cancer.
Prognostic impact of Metadherin-SND1 interaction in colon cancer.
Role of metadherin in estrogen-regulated gene expression.
The FBXW7 tumor suppressor inhibits breast cancer proliferation and promotes apoptosis by targeting MTDH for degradation.
Carcinoma
Apoptosis of human non-small-cell lung cancer A549 cells triggered by evodiamine through MTDH-dependent signaling pathway.
Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma.
Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue.
Increased expression of metadherin protein predicts worse disease-free and overall survival in laryngeal squamous cell carcinoma.
Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer.
Metadherin is required for the proliferation, migration, and invasion of esophageal squamous cell carcinoma and its meta-analysis.
MicroRNA?98/PTEN/AKT pathway inhibits cell proliferation and malignant progression of hypopharyngeal carcinoma by MTDH.
MiR-98 inhibits malignant progression via targeting MTDH in squamous cell carcinoma of the head and neck.
MTDH in macrophages promotes the vasculogenic mimicry via VEGFA-165/Flt-1 signaling pathway in head and neck squamous cell carcinoma.
MTDH promotes metastasis of clear cell renal cell carcinoma by activating SND1-mediated ERK signaling and epithelial-mesenchymal transition.
[Expression and clinical significance of MTDH, HIF-1? and TKTL1 in laryngeal carcinoma].
[Expression and significance of MTDH and MMP-9 in laryngeal squamous cell carcinoma].
Carcinoma, Hepatocellular
A Preliminary Study on Metadherin as a Potential Marker for Progression of Diffuse Large B Cell Lymphoma.
CPEB3-mediated MTDH mRNA translational suppression restrains hepatocellular carcinoma progression.
Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment.
Lentiviral-Mediated Short Hairpin RNA Knockdown of MTDH Inhibits Cell Growth and Induces Apoptosis by Regulating the PTEN/AKT Pathway in Hepatocellular Carcinoma.
Metadherin-PRMT5 complex enhances the metastasis of hepatocellular carcinoma through the WNT-?-catenin signaling pathway.
miR-217 suppresses proliferation, migration, and invasion promoting apoptosis via targeting MTDH in hepatocellular carcinoma.
Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma.
Repression of metadherin inhibits biological behavior of prostate cancer cells and enhances their sensitivity to cisplatin.
Carcinoma, Intraductal, Noninfiltrating
Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue.
Molecular differences between ductal carcinoma in situ and adjacent invasive breast carcinoma: A multiplex ligation-dependent probe amplification study.
Carcinoma, Non-Small-Cell Lung
Apoptosis of human non-small-cell lung cancer A549 cells triggered by evodiamine through MTDH-dependent signaling pathway.
Long noncoding RNA SNHG1 promotes non-small cell lung cancer progression by up-regulating MTDH via sponging miR-145-5p.
MicroRNA-584 inhibits cell proliferation and invasion in non-small cell lung cancer by directly targeting MTDH.
miR-145 and miR-497 suppress TGF-?-induced epithelial-mesenchymal transition of non-small cell lung cancer by targeting MTDH.
Carcinoma, Renal Cell
MTDH promotes metastasis of clear cell renal cell carcinoma by activating SND1-mediated ERK signaling and epithelial-mesenchymal transition.
Carcinoma, Squamous Cell
Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma.
Metadherin confers chemoresistance of cervical cancer cells by inducing autophagy and activating ERK/NF-?B pathway.
Metadherin is required for the proliferation, migration, and invasion of esophageal squamous cell carcinoma and its meta-analysis.
MiR-98 inhibits malignant progression via targeting MTDH in squamous cell carcinoma of the head and neck.
MTDH in macrophages promotes the vasculogenic mimicry via VEGFA-165/Flt-1 signaling pathway in head and neck squamous cell carcinoma.
[Expression and clinical significance of MTDH, HIF-1? and TKTL1 in laryngeal carcinoma].
Cluster Headache
Implications for the migraine SNP rs1835740 in a Swedish cluster headache population.
Colitis
MTDH promotes intestinal inflammation by positively regulating TLR signaling.
Colonic Neoplasms
Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells.
Prognostic impact of Metadherin-SND1 interaction in colon cancer.
Colorectal Neoplasms
Activation of EMT in colorectal cancer by MTDH/NF-?B p65 pathway.
Effect of modification of MTDH gene expression on colorectal cancer aggressiveness.
Knockdown of metadherin inhibits cell proliferation and migration in colorectal cancer.
MicroRNA-1271 suppresses the proliferation and invasion of colorectal cancer cells by regulating metadherin/Wnt signaling.
microRNA-877 inhibits malignant progression of colorectal cancer by directly targeting MTDH and regulating the PTEN/Akt pathway.
MiR-182-5p inhibited proliferation and metastasis of colorectal cancer by targeting MTDH.
MTDH and MAP3K1 are direct targets of apoptosis-regulating miRNAs in colorectal carcinoma.
MTDH genetic variants in colorectal cancer patients.
RARRES3 suppressed metastasis through suppression of MTDH to regulate epithelial-mesenchymal transition in colorectal cancer.
Embolism
Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance.
Endometrial Neoplasms
Cytoplasmic Metadherin (MTDH) Provides Survival Advantage under Conditions of Stress by Acting as RNA-binding Protein.
Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment.
Role of metadherin in estrogen-regulated gene expression.
Transcriptional Repression of Raf Kinase Inhibitory Protein Gene by Metadherin during Cancer Progression.
Epilepsy
Genetics of migraine aura: an update.
Esophageal Squamous Cell Carcinoma
Metadherin is required for the proliferation, migration, and invasion of esophageal squamous cell carcinoma and its meta-analysis.
Fanconi Anemia
MTDH/AEG-1 downregulation using pristimerin-loaded nanoparticles inhibits Fanconi anemia proteins and increases sensitivity to platinum-based chemotherapy.
Fibroadenoma
[Expression and clinical significance of MTDH and VEGF in triple-negative breast cancer].
Glioblastoma
AEG-1-AKT2: A novel complex controlling the aggressiveness of glioblastoma.
Post-trimodality expression levels of metadherin (MTDH) as a prognostic biomarker for esophageal adenocarcinoma patients.
Glioma
A Preliminary Study on Metadherin as a Potential Marker for Progression of Diffuse Large B Cell Lymphoma.
Correlated overexpression of metadherin and SND1 in glioma cells.
microRNA-1471 suppresses glioma cell growth and invasion by repressing metadherin expression.
MicroRNA-202 inhibits cell proliferation, migration and invasion of glioma by directly targeting metadherin.
MicroRNA-379 inhibits cell proliferation and invasion in glioma via targeting metadherin and regulating PTEN/AKT pathway.
MicroRNA?216b inhibits cell proliferation and invasion in glioma by directly targeting metadherin.
MiR-302c-3p suppresses invasion and proliferation of glioma cells via down-regulating metadherin (MTDH) expression.
MiR-30b-5p modulates glioma cell proliferation by direct targeting MTDH.
MTDH promotes glioma invasion through regulating miR-130b-ceRNAs.
Hepatitis B
Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma.
Hepatitis B, Chronic
Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma.
Infertility, Male
Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs.
Kidney Neoplasms
Metadherin in prostate, bladder, and kidney cancer: A systematic review.
Klatskin Tumor
Metadherin overexpression in perihilar cholangiocarcinoma is associated with lymph node metastasis and poor prognosis.
Leukemia, Lymphocytic, Chronic, B-Cell
Metadherin contributes to the pathogenesis of chronic lymphocytic leukemia partially through Wnt/?-catenin pathway.
Liver Neoplasms
Overexpression of microRNA-30a-5p inhibits liver cancer cell proliferation and induces apoptosis by targeting MTDH/PTEN/AKT pathway.
Lung Neoplasms
Apoptosis of human non-small-cell lung cancer A549 cells triggered by evodiamine through MTDH-dependent signaling pathway.
FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs.
Huaier Granule extract inhibit the proliferation and metastasis of lung cancer cells through down-regulation of MTDH, JAK2/STAT3 and MAPK signaling pathways.
Long noncoding RNA SNHG1 promotes non-small cell lung cancer progression by up-regulating MTDH via sponging miR-145-5p.
MicroRNA-584 inhibits cell proliferation and invasion in non-small cell lung cancer by directly targeting MTDH.
miR-145 and miR-497 suppress TGF-?-induced epithelial-mesenchymal transition of non-small cell lung cancer by targeting MTDH.
Repression of metadherin inhibits biological behavior of prostate cancer cells and enhances their sensitivity to cisplatin.
Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis.
Lymphatic Metastasis
Association of MTDH immunohistochemical expression with metastasis and prognosis in female reproduction malignancies: a systematic review and meta-analysis.
Correlation between down-expression of miR-431 and clinicopathological significance in HCC tissues.
Elevated expression of MTDH predicts better prognosis of locally advanced HER-2 positive breast cancer patients receiving neoadjuvant chemotherapy plus trastuzumab.
Increased expression of metadherin protein predicts worse disease-free and overall survival in laryngeal squamous cell carcinoma.
Metadherin Expression is Associated with Extrathyroidal Extension in Papillary Thyroid Cancer Patients.
Metadherin is required for the proliferation, migration, and invasion of esophageal squamous cell carcinoma and its meta-analysis.
Metadherin overexpression in perihilar cholangiocarcinoma is associated with lymph node metastasis and poor prognosis.
Metadherin regulates actin cytoskeletal remodeling and enhances human gastric cancer metastasis via epithelial-mesenchymal transition.
[Expression and clinical significance of MTDH and VEGF in triple-negative breast cancer].
Lymphoma
Metadherin contributes to the pathogenesis of diffuse large B-cell lymphoma.
Metadherin interference inhibits proliferation and enhances chemo-sensitivity to doxorubicin in diffuse large B cell lymphoma.
Lymphoma, B-Cell
A Preliminary Study on Metadherin as a Potential Marker for Progression of Diffuse Large B Cell Lymphoma.
Metadherin interference inhibits proliferation and enhances chemo-sensitivity to doxorubicin in diffuse large B cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
A Preliminary Study on Metadherin as a Potential Marker for Progression of Diffuse Large B Cell Lymphoma.
Metadherin interference inhibits proliferation and enhances chemo-sensitivity to doxorubicin in diffuse large B cell lymphoma.
Melanoma
A Preliminary Study on Metadherin as a Potential Marker for Progression of Diffuse Large B Cell Lymphoma.
MicroRNA?675 inhibits cell proliferation and invasion in melanoma by directly targeting metadherin.
miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy.
Post-trimodality expression levels of metadherin (MTDH) as a prognostic biomarker for esophageal adenocarcinoma patients.
[Expression and prognostic value of MTDH, Bcl-2 and E-cadherin in sinonasal malignant mucosal melanoma].
Migraine Disorders
Genetics of migraine aura: an update.
Implications for the migraine SNP rs1835740 in a Swedish cluster headache population.
Migraine with Aura
Genetics of migraine aura: an update.
Multiple Myeloma
MTDH is an oncogene in multiple myeloma, which is suppressed by Bortezomib treatment.
Neoplasm Metastasis
Activation of EMT in colorectal cancer by MTDH/NF-?B p65 pathway.
Association of MTDH immunohistochemical expression with metastasis and prognosis in female reproduction malignancies: a systematic review and meta-analysis.
Correlation between down-expression of miR-431 and clinicopathological significance in HCC tissues.
CPEB3-mediated MTDH mRNA translational suppression restrains hepatocellular carcinoma progression.
Elevated expression of MTDH predicts better prognosis of locally advanced HER-2 positive breast cancer patients receiving neoadjuvant chemotherapy plus trastuzumab.
Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer.
Expression of MTDH and IL-10 Is an Independent Predictor of Worse Prognosis in ER-Negative or PR-Negative Breast Cancer Patients.
FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs.
Gene expression profiling of the 8q22-24 position in human breast cancer: TSPYL5, MTDH, ATAD2 and CCNE2 genes are implicated in oncogenesis, while WISP1 and EXT1 genes may predict a risk of metastasis.
Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis.
Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes.
Huaier Granule extract inhibit the proliferation and metastasis of lung cancer cells through down-regulation of MTDH, JAK2/STAT3 and MAPK signaling pathways.
Hypoxia promotes migration/invasion and glycolysis in head and neck squamous cell carcinoma via an HIF-1?-MTDH loop.
Identification of Staphylococcal nuclease domain containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions.
Increased expression of metadherin protein predicts worse disease-free and overall survival in laryngeal squamous cell carcinoma.
Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer.
Metadherin expression and lung relapse in patients with colorectal carcinoma.
Metadherin Expression is Associated with Extrathyroidal Extension in Papillary Thyroid Cancer Patients.
Metadherin in prostate, bladder, and kidney cancer: A systematic review.
Metadherin is required for the proliferation, migration, and invasion of esophageal squamous cell carcinoma and its meta-analysis.
Metadherin overexpression in perihilar cholangiocarcinoma is associated with lymph node metastasis and poor prognosis.
Metadherin Promotes Malignant Phenotypes And Induces Beta-Catenin Nuclear Translocation And Epithelial-Mesenchymal Transition In Gastric Cancer.
Metadherin promotes metastasis by supporting putative cancer stem cell properties and epithelial plasticity in pancreatic cancer.
Metadherin regulates actin cytoskeletal remodeling and enhances human gastric cancer metastasis via epithelial-mesenchymal transition.
Metadherin regulates metastasis of squamous cell carcinoma of the head and neck via AKT signalling pathway-mediated epithelial- mesenchymal transition.
Metadherin regulates proliferation and metastasis via actin cytoskeletal remodelling in non-small cell lung cancer.
Metadherin Regulation of Vascular Endothelial Growth Factor Expression Is Dependent Upon the PI3K/Akt Pathway in Squamous Cell Carcinoma of the Head and Neck.
Metadherin-PRMT5 complex enhances the metastasis of hepatocellular carcinoma through the WNT-?-catenin signaling pathway.
Metadherin: An emerging key regulator of the malignant progression of multiple cancers.
MicroRNA-154 inhibits the growth and metastasis of gastric cancer cells by directly targeting MTDH.
MicroRNA-202 inhibits cell proliferation, migration and invasion of glioma by directly targeting metadherin.
microRNA-22 acts as a metastasis suppressor by targeting metadherin in gastric cancer.
MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin.
MicroRNA-320a inhibits breast cancer metastasis by targeting metadherin.
MicroRNA-618 Directly Targets Metadherin mRNA To Suppress The Malignant Phenotype Of Osteosarcoma Cells By Reducing PTEN-AKT Pathway Output.
MiR-1297 suppresses pancreatic cancer cell proliferation and metastasis by targeting MTDH.
miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma.
MiR-182-5p inhibited proliferation and metastasis of colorectal cancer by targeting MTDH.
miR-26a suppresses tumour proliferation and metastasis by targeting metadherin in triple negative breast cancer.
miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy.
miR?3664?5P suppresses the proliferation and metastasis of gastric cancer by attenuating the NF??B signaling pathway through targeting MTDH.
MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer.
MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma.
MTDH in macrophages promotes the vasculogenic mimicry via VEGFA-165/Flt-1 signaling pathway in head and neck squamous cell carcinoma.
MTDH promotes metastasis of clear cell renal cell carcinoma by activating SND1-mediated ERK signaling and epithelial-mesenchymal transition.
Overexpression of metadherin mediates metastasis of osteosarcoma by regulating epithelial-mesenchymal transition.
RARRES3 suppressed metastasis through suppression of MTDH to regulate epithelial-mesenchymal transition in colorectal cancer.
Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer.
Silencing the expression of MTDH increases the radiation sensitivity of SKOV3 ovarian cancer cells and reduces their proliferation and metastasis.
Synergistic Effect of Cold Atmospheric Plasma and Drug Loaded Core-shell Nanoparticles on Inhibiting Breast Cancer Cell Growth.
The essential role of MTDH in the progression of HCC: a study with immunohistochemistry, TCGA, meta-analysis and in vitro investigation.
The multifaceted role of MTDH/AEG-1 in cancer progression.
The targeting of MTDH by miR?145?5p or miR?145?3p is associated with prognosis and regulates the growth and metastasis of prostate cancer cells.
Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis.
Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance.
[Expression and clinical significance of MTDH and VEGF in triple-negative breast cancer].
[Expression and clinical significance of MTDH, HIF-1? and TKTL1 in laryngeal carcinoma].
[Expression and significance of MTDH and MMP-9 in laryngeal squamous cell carcinoma].
Neoplasms
A polysaccharide from Trametes robiniophila Murrill induces apoptosis through intrinsic mitochondrial pathway in human osteosarcoma (U-2 OS) cells.
A Preliminary Study on Metadherin as a Potential Marker for Progression of Diffuse Large B Cell Lymphoma.
AEG-1 Regulates TWIK-1 Expression as an RNA-Binding Protein in Astrocytes.
AEG-1-AKT2: A novel complex controlling the aggressiveness of glioblastoma.
Apoptosis of human non-small-cell lung cancer A549 cells triggered by evodiamine through MTDH-dependent signaling pathway.
Association of MTDH immunohistochemical expression with metastasis and prognosis in female reproduction malignancies: a systematic review and meta-analysis.
Astrocyte elevated gene-1 and breast cancer (Review).
Correlated overexpression of metadherin and SND1 in glioma cells.
Cytoplasmic Metadherin (MTDH) Provides Survival Advantage under Conditions of Stress by Acting as RNA-binding Protein.
Deregulation of MTDH Gene Expression in Gastric Cancer.
Downregulation of miR-375 in aldosterone-producing adenomas promotes tumour cell growth via MTDH.
Effect of modification of MTDH gene expression on colorectal cancer aggressiveness.
Efficient and tumor-specific knockdown of MTDH gene attenuates paclitaxel resistance of breast cancer cells both in vivo and in vitro.
Elevated expression of MTDH predicts better prognosis of locally advanced HER-2 positive breast cancer patients receiving neoadjuvant chemotherapy plus trastuzumab.
Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer.
Establishment and Characterization of MTDH Knockdown by Artificial MicroRNA Interference - Functions as a Potential Tumor Suppressor in Breast Cancer.
Expression of MTDH and IL-10 Is an Independent Predictor of Worse Prognosis in ER-Negative or PR-Negative Breast Cancer Patients.
FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs.
Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis.
Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes.
Hypoxia promotes migration/invasion and glycolysis in head and neck squamous cell carcinoma via an HIF-1?-MTDH loop.
Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue.
Increased expression of metadherin protein predicts worse disease-free and overall survival in laryngeal squamous cell carcinoma.
Increased HSF1 Promotes Infiltration and Metastasis in Cervical Cancer via Enhancing MTDH-VEGF-C Expression.
Knockdown of metadherin inhibits cell proliferation and migration in colorectal cancer.
Lentiviral-Mediated Short Hairpin RNA Knockdown of MTDH Inhibits Cell Growth and Induces Apoptosis by Regulating the PTEN/AKT Pathway in Hepatocellular Carcinoma.
Metadherin enhances vulnerability of cancer cells to ferroptosis.
Metadherin Expression is Associated with Extrathyroidal Extension in Papillary Thyroid Cancer Patients.
Metadherin in prostate, bladder, and kidney cancer: A systematic review.
Metadherin is a novel prognostic marker for bladder cancer progression and overall patient survival.
Metadherin Is a Prognostic Apoptosis Modulator in Mesothelioma Induced via NF-?B-Mediated Signaling.
Metadherin overexpression in perihilar cholangiocarcinoma is associated with lymph node metastasis and poor prognosis.
Metadherin Promotes Malignant Phenotypes And Induces Beta-Catenin Nuclear Translocation And Epithelial-Mesenchymal Transition In Gastric Cancer.
Metadherin promotes metastasis by supporting putative cancer stem cell properties and epithelial plasticity in pancreatic cancer.
Metadherin regulates actin cytoskeletal remodeling and enhances human gastric cancer metastasis via epithelial-mesenchymal transition.
Metadherin regulates epithelial-mesenchymal transition in carcinoma.
Metadherin regulates radioresistance in cervical cancer cells.
Metadherin/Astrocyte elevated gene-1 positively regulates the stability and function of forkhead box M1 during tumorigenesis.
Metadherin: A Therapeutic Target in Multiple Cancers.
Metadherin: An emerging key regulator of the malignant progression of multiple cancers.
Micheliolide ameliorates diabetic kidney disease by inhibiting Mtdh-mediated renal inflammation in type 2 diabetic db/db mice.
MicroRNA-136 functions as a tumor suppressor in osteosarcoma via regulating metadherin.
MicroRNA-154 inhibits the growth and metastasis of gastric cancer cells by directly targeting MTDH.
MicroRNA-379 inhibits cell proliferation and invasion in glioma via targeting metadherin and regulating PTEN/AKT pathway.
MicroRNA-559 plays an inhibitory role in the malignant progression of glioblastoma cells by directly targeting metadherin.
microRNA-877 inhibits malignant progression of colorectal cancer by directly targeting MTDH and regulating the PTEN/Akt pathway.
MicroRNA?216b inhibits cell proliferation and invasion in glioma by directly targeting metadherin.
miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma.
MiR-26a inhibits proliferation and migration of breast cancer through repression of MCL-1.
MiR-302c inhibits tumor growth of hepatocellular carcinoma by suppressing the endothelial-mesenchymal transition of endothelial cells.
MiR-302c-3p suppresses invasion and proliferation of glioma cells via down-regulating metadherin (MTDH) expression.
MIR137/MIR2682 locus is associated with perineural invasiveness in head and neck cancer.
MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma.
MTDH and MAP3K1 are direct targets of apoptosis-regulating miRNAs in colorectal carcinoma.
MTDH genetic variants in colorectal cancer patients.
MTDH in macrophages promotes the vasculogenic mimicry via VEGFA-165/Flt-1 signaling pathway in head and neck squamous cell carcinoma.
MTDH is an oncogene in multiple myeloma, which is suppressed by Bortezomib treatment.
MTDH promotes glioma invasion through regulating miR-130b-ceRNAs.
MTDH promotes metastasis of clear cell renal cell carcinoma by activating SND1-mediated ERK signaling and epithelial-mesenchymal transition.
MTDH/AEG-1 downregulation using pristimerin-loaded nanoparticles inhibits Fanconi anemia proteins and increases sensitivity to platinum-based chemotherapy.
Overcoming cisplatin resistance by targeting the MTDH-PTEN interaction in ovarian cancer with sera derived from rats exposed to Guizhi Fuling wan extract.
Overexpression of microRNA-30a-5p inhibits liver cancer cell proliferation and induces apoptosis by targeting MTDH/PTEN/AKT pathway.
Phenethyl Isothiocyanate Suppresses Stemness in the Chemo- and Radio-Resistant Triple-Negative Breast Cancer Cell Line MDA-MB-231/IR Via Downregulation of Metadherin.
Post-trimodality expression levels of metadherin (MTDH) as a prognostic biomarker for esophageal adenocarcinoma patients.
Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma.
Repression of metadherin inhibits biological behavior of prostate cancer cells and enhances their sensitivity to cisplatin.
Role of metadherin in estrogen-regulated gene expression.
Silencing the expression of MTDH increases the radiation sensitivity of SKOV3 ovarian cancer cells and reduces their proliferation and metastasis.
SU6668 modulates prostate cancer progression by downregulating MTDH/AKT signaling pathway.
TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance.
The essential role of MTDH in the progression of HCC: a study with immunohistochemistry, TCGA, meta-analysis and in vitro investigation.
The FBXW7 tumor suppressor inhibits breast cancer proliferation and promotes apoptosis by targeting MTDH for degradation.
The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility.
The multifaceted role of MTDH/AEG-1 in cancer progression.
The Oncogene Metadherin Modulates the Apoptotic Pathway Based on the Tumor Necrosis Factor Superfamily Member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in Breast Cancer.
The targeting of MTDH by miR?145?5p or miR?145?3p is associated with prognosis and regulates the growth and metastasis of prostate cancer cells.
Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis.
TNFAIP2 expression induces epithelial-to-mesenchymal transition and confers platinum resistance in urothelial cancer cells.
Transcriptional Repression of Raf Kinase Inhibitory Protein Gene by Metadherin during Cancer Progression.
Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance.
[Expression and clinical significance of MTDH and VEGF in triple-negative breast cancer].
[Expression and clinical significance of MTDH, HIF-1? and TKTL1 in laryngeal carcinoma].
[Expression of EphA7 and MTDH and clinicopathological significance in the squamous cell cancer of the tongue].
Neoplasms, Squamous Cell
[Expression of EphA7 and MTDH and clinicopathological significance in the squamous cell cancer of the tongue].
Neuroblastoma
Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment.
Repression of metadherin inhibits biological behavior of prostate cancer cells and enhances their sensitivity to cisplatin.
Osteosarcoma
A polysaccharide from Trametes robiniophila Murrill induces apoptosis through intrinsic mitochondrial pathway in human osteosarcoma (U-2 OS) cells.
Circular RNA Circ-03955 Promotes Epithelial-Mesenchymal Transition in Osteosarcoma by Regulating miR-3662/Metadherin Pathway.
Ovarian Neoplasms
Association of MTDH immunohistochemical expression with metastasis and prognosis in female reproduction malignancies: a systematic review and meta-analysis.
Mechanism of Low Expression of miR-30a-5p on Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer.
Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer.
miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma.
Overcoming cisplatin resistance by targeting the MTDH-PTEN interaction in ovarian cancer with sera derived from rats exposed to Guizhi Fuling wan extract.
Silencing the expression of MTDH increases the radiation sensitivity of SKOV3 ovarian cancer cells and reduces their proliferation and metastasis.
The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility.
Pancreatic Neoplasms
MiR-1297 suppresses pancreatic cancer cell proliferation and metastasis by targeting MTDH.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway.
Prostatic Hyperplasia
Repression of metadherin inhibits biological behavior of prostate cancer cells and enhances their sensitivity to cisplatin.
Prostatic Neoplasms
Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis.
Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment.
Metadherin is an apoptotic modulator in prostate cancer through miR-342-3p regulation.
Repression of metadherin inhibits biological behavior of prostate cancer cells and enhances their sensitivity to cisplatin.
SU6668 modulates prostate cancer progression by downregulating MTDH/AKT signaling pathway.
The targeting of MTDH by miR?145?5p or miR?145?3p is associated with prognosis and regulates the growth and metastasis of prostate cancer cells.
Sarcoma
CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression.
Squamous Cell Carcinoma of Head and Neck
Hypoxia promotes migration/invasion and glycolysis in head and neck squamous cell carcinoma via an HIF-1?-MTDH loop.
Increased expression of metadherin protein predicts worse disease-free and overall survival in laryngeal squamous cell carcinoma.
MTDH in macrophages promotes the vasculogenic mimicry via VEGFA-165/Flt-1 signaling pathway in head and neck squamous cell carcinoma.
[Expression and significance of MTDH and MMP-9 in laryngeal squamous cell carcinoma].
Stomach Neoplasms
circALPL Sponges miR-127 to Promote Gastric Cancer Progression by Enhancing MTDH Expression.
Deregulation of MTDH Gene Expression in Gastric Cancer.
Metadherin Promotes Malignant Phenotypes And Induces Beta-Catenin Nuclear Translocation And Epithelial-Mesenchymal Transition In Gastric Cancer.
Metadherin regulates actin cytoskeletal remodeling and enhances human gastric cancer metastasis via epithelial-mesenchymal transition.
MicroRNA-154 inhibits the growth and metastasis of gastric cancer cells by directly targeting MTDH.
MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin.
microRNA-22 acts as a metastasis suppressor by targeting metadherin in gastric cancer.
miR?3664?5P suppresses the proliferation and metastasis of gastric cancer by attenuating the NF??B signaling pathway through targeting MTDH.
Thyroid Cancer, Papillary
Metadherin Expression is Associated with Extrathyroidal Extension in Papillary Thyroid Cancer Patients.
Tics
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.
Tongue Neoplasms
[Expression of EphA7 and MTDH and clinicopathological significance in the squamous cell cancer of the tongue].
Triple Negative Breast Neoplasms
A novel metadherin?7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NF?B-SIRT3 axis.
AMPK inhibits MTDH expression via GSK3? and SIRT1 activation: potential role in triple negative breast cancer cell proliferation.
SU6668 suppresses proliferation of triple negative breast cancer cells through down-regulating MTDH expression.
[Expression and clinical significance of MTDH and VEGF in triple-negative breast cancer].
Urinary Bladder Neoplasms
Long noncoding RNA OIP5-AS1 exhibits oncogenic activity in bladder cancer through miR-217 and MTDH.
Metadherin is a novel prognostic marker for bladder cancer progression and overall patient survival.
Urologic Neoplasms
Metadherin in prostate, bladder, and kidney cancer: A systematic review.
Uterine Cervical Neoplasms
Association of MTDH immunohistochemical expression with metastasis and prognosis in female reproduction malignancies: a systematic review and meta-analysis.
Metadherin confers chemoresistance of cervical cancer cells by inducing autophagy and activating ERK/NF-?B pathway.
Metadherin regulates radioresistance in cervical cancer cells.
MicroRNA-433 inhibits cervical cancer progression by directly targeting metadherin to regulate the AKT and ?-catenin signalling pathways.