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Information on EC 1.1.3.13 - alcohol oxidase
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1.1.3.13 alcohol oxidaseIUBMB Comments
The enzymes from the fungi Candida methanosorbosa and several Basidiomycetes species contain an FAD cofactor [1,3]. The enzyme from the phytopathogenic fungi Colletotrichum graminicola and Colletotrichum gloeosporioides utilize a mononuclear copper-radical mechanism . The enzyme acts on primary alcohols and unsaturated alcohols, and has much lower activity with branched-chain and secondary alcohols.
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Word Map
- 1.1.3.13
- pichia
- pastoris
-
methylotrophic
- polymorpha
- hansenula
-
biosensors
- catalase
- formaldehyde
-
electrode
- candida
-
methanol-inducible
- oxidases
-
amperometric
- boidinii
- alpha-factor
- analysis
-
methanol-utilizing
-
flavoenzyme
-
octameric
- dihydroxyacetone
- methanolica
-
methanol-grown
-
vanillyl
- microbodies
-
alpha-mating
-
isoamyl
-
coniferyl
-
ogataea
- komagataella
-
ppic9k
- biotechnology
-
peroxisome-deficient
- synthesis
- molecular biology
- degradation
- simplicissimum
-
zeocin
-
screen-printed
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
alcohol oxidase, alcohol oxidase 1, methanol oxidase, alcohol oxidase i, ethanol oxidase, peroxisomal alcohol oxidase, mod1p, mod2p, alcohol oxidase a, alcox, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AlcOx
AOd
AOext
AOint
AOX
AOX1
EC 1.1.3.31
-
-
formerly
-
ethanol oxidase
extracellular alcohol oxidase
FAD-dependent alcohol oxidase
FAO1
intracellular alcohol oxidase
methanol oxidase
oxidase, alcohol
-
-
-
-
P-AOD
primary alcohol oxidase
SCAO
short chain alcohol oxidase
VAO
veratryl alcohol oxidase
AOX
-
-
ethanol oxidase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a primary alcohol + O2 = an aldehyde + H2O2
ping-pong mechanism operates via a two-electron transfer from substrate to oxygen
-
a primary alcohol + O2 = an aldehyde + H2O2
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
alcohol:oxygen oxidoreductase
The enzymes from the fungi Candida methanosorbosa and several Basidiomycetes species contain an FAD cofactor [1,3]. The enzyme from the phytopathogenic fungi Colletotrichum graminicola and Colletotrichum gloeosporioides utilize a mononuclear copper-radical mechanism [4]. The enzyme acts on primary alcohols and unsaturated alcohols, and has much lower activity with branched-chain and secondary alcohols.
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CAS REGISTRY NUMBER
COMMENTARY
9073-63-6
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,4-butynediol + O2
4-hydroxy-2-butyn-1-al + H2O2
-
oxidized to mechanism-based irreversible inactivator: 4-hydroxy-2-butynal
mechanism-based inhibitor
?
1-butanol + O2
butanaldehyde + H2O2
-
intra- and extracellular enzymes, low activity with the intracellular enzyme
-
-
?
1-pentanol + O2
pentanaldehyde + H2O2
-
intra- and extracellular enzymes, low activity with the intracellular enzyme
-
-
?
2 5-aminopentan-1-ol + O2
5-(piperidin-2-yl)-2,3,4,5-tetrahydropyridine + H2O2
-
-
-
?
2,2'-sulfanediyldi(ethan-1-ol) + O2
[(2-hydroxyethyl)sulfanyl]acetic acid + H2O2
-
-
-
?
2,2'-[ethane-1,2-diylbis(oxy)]di(ethan-1-ol) + O2
[2-(2-oxoethoxy)ethoxy]acetic acid + H2O2
-
-
-
?
2-chloroethanol + O2
2-chloroethanal + H2O2
-
66% of the activity with methanol
-
-
?
2-cyanoethanol + O2
2-cyanoethanal + H2O2
-
30% of the activity with methanol
-
-
?
2-methoxyethanol + O2
2-methoxyethanal + H2O2
-
40% of the activity with methanol
-
-
?
2-methyl-1-butanol + O2
2-methyl-1-butanal + H2O2
-
22% of the activity with methanol
-
-
?
2-methyl-1-propanol + O2
butan-2-one + H2O2
7% of the activity with methanol
-
-
?
2-methyl-2-propanol + O2
?
-
extracellular enzyme, no activity with the intracellular enzyme
-
-
?
3-chloro-1-propanol + O2
3-chloro-1-propanal + H2O2
-
22% of the activity with methanol
-
-
?
3-methyl-1-butanol + O2
3-methylbutanal + H2O2
7% of the activity with methanol
-
-
?
4-chloro-1-butanol + O2
4-chloro-1-butanal + H2O2
-
11% of the activity with methanol
-
-
?
arabitol + O2
?
-
extracellular enzyme, no activity with the intracellular enzyme
-
-
?
diethylene glycol + 2 O2
2-(2-hydroxyethoxy)acetic acid + H2O2
-
-
-
?
formaldehyde + p-benzoquinone
formic acid + p-benzoquinol
-
p-benzoquinone, having the highest redox potential, proves to be the most efficient artificial electron acceptor
-
-
?
hexane-1,6-diol + O2
6-oxohexanoic acid + cyclopent-1-ene-1-carbaldehyde + H2O2
-
-
-
?
pentane-1,5-diol + O2
5-hydroxypentanoic acid + H2O2
-
-
-
?
prop-2-en-1-ol + O2
acrylaldehyde + H2O2
-
81% of the activity with methanol
-
-
?
propylene glycol + O2
?
-
low activity with intra- and extracellular enzymes
-
-
?
1-butanol + O2
butanal + H2O2
-
-
-
?
1-butanol + O2
n-butanal + H2O2
-
49% of the activity with methanol
-
-
?
1-butanol + O2
n-butanal + H2O2
-
49% of the activity with methanol
-
-
?
1-butanol + O2
n-butanal + H2O2
54% of the activity with methanol
-
-
?
1-octanol + O2
n-octanal + H2O2
-
2.4% of the activity with methanol
-
-
?
1-pentanol + O2
n-pentanal + H2O2
-
21% of the activity with methanol
-
-
?
1-pentanol + O2
n-pentanal + H2O2
-
21% of the activity with methanol
-
-
?
1-pentanol + O2
n-pentanal + H2O2
22% of the activity with methanol
-
-
?
1-pentanol + O2
n-pentanal + H2O2
-
33.5% of the activity with methanol
-
-
?
1-pentanol + O2
n-pentanal + H2O2
[Candida] methanosorbosa M-2003
-
33.5% of the activity with methanol
-
-
?
1-pentanol + O2
pentanal + H2O2
-
-
-
?
1-propanol + O2
n-propanal + H2O2
-
66% of the activity with methanol
-
-
?
1-propanol + O2
n-propanal + H2O2
-
66% of the activity with methanol
-
-
?
1-propanol + O2
n-propanal + H2O2
73% of the activity with methanol
-
-
?
1-propanol + O2
n-propanal + H2O2
27% activity compared to methanol
-
-
?
1-propanol + O2
n-propanal + H2O2
Phanerodontia chrysosporium DSMZ 1547
-
27% activity compared to methanol
-
-
?
1-propanol + O2
propanal + H2O2
-
-
-
?