Disease on EC 1.1.3.22 - xanthine oxidase
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Aberrant Crypt Foci
A xanthine oxidase inhibitor 1'-acetoxychavicol acetate inhibits azoxymethane-induced colonic aberrant crypt foci in rats.
Aberrant Crypt Foci
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate.
Aberrant Crypt Foci
Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice.
Achlorhydria
[Stress-responsive systems in the rat pancreas upon long-term gastric hypochlorhydria and administration of multiprobiotic "Symbiter"].
Acidosis
Hypercapnic acidosis may attenuate acute lung injury by inhibition of endogenous xanthine oxidase.
Acidosis
Red blood cells prevent inhibition of hypoxic pulmonary vasoconstriction by nitrite in isolated, perfused rat lungs.
Acquired Immunodeficiency Syndrome
Elevated levels of xanthine oxidase in serum of patients with inflammatory and autoimmune rheumatic diseases.
Acute Kidney Injury
A semi-mechanistic exposure-response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases.
Acute Kidney Injury
An evaluation of antioxidant effects on recovery from postischemic acute renal failure.
Acute Kidney Injury
Effects of xanthine oxidase inhibition on ischemic acute renal failure in the rat.
Acute Kidney Injury
Febuxostat exerts dose-dependent renoprotection in rats with cisplatin-induced acute renal injury.
Acute Kidney Injury
The prophylactic protective effect of sesamol against ferric-nitrilotriacetate-induced acute renal injury in mice.
Acute Kidney Injury
Xanthine oxidase: evidence against a causative role in renal reperfusion injury.
Acute Lung Injury
Acute lung injury following pancreas ischaemia-reperfusion: role of xanthine oxidase.
Acute Lung Injury
Effects of inhaled NO and inhibition of endogenous NO synthesis in oxidant-induced acute lung injury.
Acute Lung Injury
Febuxostat protects rats against lipopolysaccharide-induced lung inflammation in a dose-dependent manner.
Acute Lung Injury
Hypercapnic acidosis may attenuate acute lung injury by inhibition of endogenous xanthine oxidase.
Acute Lung Injury
Methylene blue attenuates pancreas ischemia-reperfusion (IR)-induced lung injury: a dose response study in a rat model.
Acute Lung Injury
The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung.
Acute Lung Injury
Topiroxostat ameliorates oxidative stress and inflammation in sepsis-induced lung injury.
Acute Lung Injury
Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia. Role in acute lung injury.
Acute Lung Injury
Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury.
adenine phosphoribosyltransferase deficiency
Crystalline Nephropathy due to APRT Deficiency: A Preventable Cause of Renal and Renal Allograft Failure.
adenine phosphoribosyltransferase deficiency
Two-dimensional thin-layer chromatography for the screening of disorders of purine and pyrimidine metabolism.
Adenocarcinoma of Lung
Tumor necrosis factor-alpha alters response of lung cancer cells to oxidative stress.
Adenoma
Changes in free radical scavengers and lipid peroxide in thyroid glands of various thyroid disorders.
Adenomatous Polyposis Coli
Caffeine phenotyping of cytochrome P4501A2, N-acetyltransferase, and xanthine oxidase in patients with familial adenomatous polyposis.
Adenomyosis
Xanthine oxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis.
adenosine deaminase deficiency
Atmospheric pressure ionization mass spectrometry of purine and pyrimidine markers of inherited metabolic disorders.
adenosine deaminase deficiency
Two-dimensional thin-layer chromatography for the screening of disorders of purine and pyrimidine metabolism.
Albuminuria
Apoptosis induced by an uromodulin mutant C112Y and its suppression by topiroxostat.
Albuminuria
Effect of Intensive Urate Lowering With Combined Verinurad and Febuxostat on Albuminuria in Patients With Type 2 Diabetes: A Randomized Trial.
Albuminuria
Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2.
Alzheimer Disease
Invited review: Bovine milk fat globule membrane as a potential nutraceutical.
Anemia
Increased oxidative stress alters nucleosides metabolite levels in sickle cell anemia.
Anemia
The caffeine metabolic ratio as an index of xanthine oxidase activity in clinically active and silent celiac patients.
Anemia
The effect of xanthine oxidase and hypoxanthine on the permeability of red cells from patients with sickle cell anemia.
Anemia, Sickle Cell
Increased oxidative stress alters nucleosides metabolite levels in sickle cell anemia.
Anemia, Sickle Cell
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease.
Anemia, Sickle Cell
The effect of xanthine oxidase and hypoxanthine on the permeability of red cells from patients with sickle cell anemia.
Anemia, Sickle Cell
Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease.
Aneurysm
Increased oxidative stress and xanthine oxidase activity in human ruptured cerebral aneurysms.
Aneurysm
Prooxidant iron and copper, with ferroxidase and xanthine oxidase activities in human atherosclerotic material.
Angina Pectoris
Pharmacotherapy: Xanthine oxidase inhibition for relief of angina pectoris.
Angina Pectoris
[Xanthine oxidase in homogenized cow's milk and Oster's hypothesis: a review]
Aortic Aneurysm
Increased oxidative stress and xanthine oxidase activity in human ruptured cerebral aneurysms.
Apnea
Competitive apnea diving sessions induces an adaptative antioxidant response in mononucleated blood cells.
Arrhythmias, Cardiac
Non-invasive limb ischemic pre-conditioning reduces oxidative stress and attenuates myocardium ischemia-reperfusion injury in diabetic rats.
Arrhythmias, Cardiac
Noninvasive delayed limb ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in rats by a mitochondrial K(ATP) channel-dependent mechanism.
Arrhythmias, Cardiac
Serum uric acid level is associated with reperfusion ventricular arrhythmias in acute myocardial infarction.
Arthritis
Effects of allopurinol on in vivo suppression of arthritis in mice and ex vivo modulation of phagocytic production of oxygen radicals in whole human blood.
Arthritis
Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles.
Arthritis
Kinetic study on the inhibition of xanthine oxidase by extracts from two selected Algerian plants traditionally used for the treatment of inflammatory diseases.
Arthritis
Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors.
Arthritis
[Oxygen free radicals mediate an inhibition of DNA and matrix proteoglycan, collagen synthesis in cultured human embryo chondrocytes]
Arthritis
[Purine metabolism enzymes in diagnosis and differential diagnosis of osteoarthritis and gout arthritis]
Arthritis
[The relationship between antipyrine kinetics, the seromucoid content and the xanthine oxidase activity in the plasma of rats with acute and chronic inflammation]
Arthritis
[Xanthine oxidase activity: O2-dependent and NAD+-dependent forms in the liver, in rats with adjuvant arthritis and hepatitis]
Arthritis, Experimental
[Xanthine oxidase activity: O2-dependent and NAD+-dependent forms in the liver, in rats with adjuvant arthritis and hepatitis]
Arthritis, Gouty
Association of Serum Uric Acid and Incident Nonspine Fractures in Elderly Men: The Osteoporotic Fractures in Men (MrOS) Study.
Arthritis, Gouty
Corrigendum to "Pharmacological Basis for Use of Selaginella moellendorffii in Gouty Arthritis: Antihyperuricemic, Anti-Inflammatory, and Xanthine Oxidase Inhibition".
Arthritis, Gouty
Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout.
Arthritis, Gouty
Effects of pharmacological reversal of hyperuricemia on features of the metabolic syndrome in patients with gouty arthritis.
Arthritis, Gouty
In vitro xanthine oxidase and albumin denaturation inhibition assay of Barringtonia racemosa L. and total phenolic content analysis for potential anti-inflammatory use in gouty arthritis.
Arthritis, Gouty
In vitro xanthine oxidase inhibitory and in vivo hypouricemic activity of herbal coded formulation (Gouticin).
Arthritis, Gouty
Innovative HPTLC method with fluorescence detection for assessment of febuxostat-montelukast combination and study of their protective effects against gouty arthritis.
Arthritis, Gouty
Novel Carbon Dots Derived from Puerariae lobatae Radix and Their Anti-Gout Effects.
Arthritis, Rheumatoid
Comparison of xanthine oxidase levels in synovial fluid from patients with rheumatoid arthritis and other joint inflammations.
Asymptomatic Infections
Posttranslational ruling of xanthine oxidase activity in bovine milk by its substrates.
Atherosclerosis
Absorption of xanthine oxidase from the intestines of rats and rabbits and its role in initiation of atherosclerosis.
Atherosclerosis
Angiotensin II induces endothelial xanthine oxidase activation: role for endothelial dysfunction in patients with coronary disease.
Atherosclerosis
Evaluation of serum cholesterol reduction and xanthine oxidase inhibition in the treatment of atherosclerosis.
Atherosclerosis
Harnessing hyperuricemia to atherosclerosis and understanding its mechanistic dependence.
Atherosclerosis
Oxidative stress in atherogenesis and arterial thrombosis: the disconnect between cellular studies and clinical outcomes.
Atherosclerosis
Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis.
Atherosclerosis
Xanthine oxidase inhibition by febuxostat attenuates experimental atherosclerosis in mice.
Atherosclerosis
Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet.
Atrial Fibrillation
Antiremodeling Effect of Xanthine Oxidase Inhibition in a Canine Model of Atrial Fibrillation.
Atrial Fibrillation
Effects of febuxostat on atrial remodeling in a rabbit model of atrial fibrillation induced by rapid atrial pacing.
Atrial Fibrillation
Xanthine Oxidase Inhibition Prevents Atrial Fibrillation in a Canine Model of Atrial Pacing-Induced left Ventricular Dysfunction.
Atrial Fibrillation
Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats.
Bacterial Infections
Enzymes involved in purine metabolism--a review of histochemical localization and functional implications.
Balkan Nephropathy
Local and Systemic Oxidative Stress in Balkan Endemic Nephropathy Is Not Associated with Xanthine Oxidase Activity.
Behcet Syndrome
The activities of serum adenosine deaminase and xanthine oxidase enzymes in Behcet's disease.
Bloom Syndrome
Comet assay analysis of repair of DNA strand breaks in normal and deficient human cells exposed to radiations and chemicals. Evidence for a repair pathway specificity of DNA ligation.
Bone Resorption
Hydrogen peroxide, but not superoxide, stimulates bone resorption in mouse calvariae.
Bone Resorption
Xanthine oxidase mediates cytokine-induced, but not hormone-induced bone resorption.
Brain Diseases
[Double deficiency of sulfite and xanthine oxidase causing encephalopathy and due to a hereditary anomaly in the metabolism of molybdenum]
Brain Edema
Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radicals.
Brain Edema
Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains.
Brain Injuries
Allopurinol pretreatment improves evoked response recovery following global cerebral ischemia in dogs.
Brain Injuries
Deoxycoformycin and oxypurinol: protection against focal ischemic brain injury in the rat.
Brain Injuries
Oxypurinol administration fails to prevent hypoxic-ischemic brain injury in neonatal rats.
Brain Injuries
The effect of infusing hypoxanthine or xanthine on hypoxic-ischemic brain injury in rabbits.
Brain Injuries, Traumatic
Increased xanthine oxidase activity after traumatic brain injury in rats.
Brain Ischemia
Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats.
Brain Ischemia
Allopurinol pretreatment improves evoked response recovery following global cerebral ischemia in dogs.
Brain Ischemia
Effect of allopurinol in focal cerebral ischemia in rats: an experimental study.
Brain Ischemia
Phospholipase A(2), reactive oxygen species, and lipid peroxidation in cerebral ischemia.
Brain Ischemia
Role of xanthine dehydrogenase and oxidase in focal cerebral ischemic injury to rat.
Brain Ischemia
Xanthine oxidase is not a major source of free radicals in focal cerebral ischemia.
Brain Ischemia
Xanthine oxidase-induced neuronal death via the oxidation of NADH: prevention by micromolar EDTA.
Brain Neoplasms
Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin.
Breast Neoplasms
Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1.
Breast Neoplasms
Molybdenum, xanthine oxidase and riboflavin levels in tamoxifen treated postmenopausal women with breast cancer.
Breast Neoplasms
Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen.
Breast Neoplasms
The emerging role of xanthine oxidase inhibition for suppression of breast cancer cell migration and metastasis associated with hypercholesterolemia.
Bronchitis
Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers.
Bronchopulmonary Dysplasia
Bronchoalveolar oxyradical inflammatory elements herald bronchopulmonary dysplasia.
Burkitt Lymphoma
Distinct modes of cell death induced by different reactive oxygen species: amino acyl chloramines mediate hypochlorous acid-induced apoptosis.
Carcinogenesis
Basis for the anti-tumor and chemopreventive activities of glucarate and the glucarate:retinoid combination.
Carcinogenesis
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate.
Carcinogenesis
Chemopreventive effect of a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate, on rat oral carcinogenesis.
Carcinogenesis
Effect of dietary molybdenum on esophageal carcinogenesis in rats induced by N-methyl-N-benzylnitrosamine.
Carcinogenesis
Studies on the mechanism of liver-carcinogenesis by certain aminoazo dyes. II. The hepatic formaldehyde dehydrogenase and xanthine oxidase activities of rats and mice in relation to DAB carcinogenesis.
Carcinogenesis
Studies on xanthine oxidase during carcinogenesis by p-dimethylaminoazobenzene.
Carcinogenesis
The inhibition of DMBA-induced carcinogenesis by neoxanthin in hamster buccal pouch.
Carcinogenesis
Xanthine oxidase acitivity in progressive spontaneous mammary carcinogenesis.
Carcinogenesis
Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice.
Carcinogenesis
[Xanthine oxydase activity in the rat liver tissue in the process oncogenesis]
Carcinoma
Adenosine deaminase, 5' nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in cancerous and noncancerous human laryngeal tissues.
Carcinoma
Adenosine deaminase, xanthine oxidase, superoxide dismutase, glutathione peroxidase activities and malondialdehyde levels in the sera of patients with head and neck carcinoma.
Carcinoma
Changes in free radical scavengers and lipid peroxide in thyroid glands of various thyroid disorders.
Carcinoma
Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1.
Carcinoma
Elevated levels of xanthine oxidase in serum of patients with inflammatory and autoimmune rheumatic diseases.
Carcinoma
Increased amidophosphoribosyltransferase and decreased xanthine oxidase activity in human and rat renal cell carcinoma.
Carcinoma, Hepatocellular
Imbalance of purine metabolism in hepatomas of different growth rates as expressed in behavior of xanthine oxidase (EC 1.2.3.2).
Carcinoma, Hepatocellular
Inhibitory effect of ascorbic Acid on the proliferation and invasion of hepatoma cells in culture.
Carcinoma, Hepatocellular
Inhibitory effect of curcumin on the invasion of rat ascites hepatoma cells in vitro and ex vivo.
Carcinoma, Hepatocellular
Inhibitory effect of gingerol on the proliferation and invasion of hepatoma cells in culture.
Carcinoma, Hepatocellular
Malignant transformation-linked imbalance: decreased xanthine oxidase activity in hepatomas.
Carcinoma, Hepatocellular
Superoxide radical potentiates invasive capacity of rat ascites hepatoma cells in vitro.
Carcinoma, Hepatocellular
Superoxide-dependent lipid peroxidation and vitamin E content of microsomes from hepatomas with different growth rates.
Carcinoma, Non-Small-Cell Lung
Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
[Astragalus polysaccharide inhibits autophagy and regulates expression of autophagy-related proteins in lung cancer A549 cells induced by xanthine oxidase].
Carcinoma, Renal Cell
Increased amidophosphoribosyltransferase and decreased xanthine oxidase activity in human and rat renal cell carcinoma.
Carcinoma, Squamous Cell
Adenosine deaminase, 5' nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in cancerous and noncancerous human laryngeal tissues.
Cardio-Renal Syndrome
Chronic Kidney Disease and Disproportionally Increased Cardiovascular Damage: Does Oxidative Stress Explain the Burden?
Cardio-Renal Syndrome
Crosstalk of Various Biomarkers That Might Provide Prompt Identification of Acute or Chronic Cardiorenal Syndromes.
Cardiomegaly
Dietary nicotinamide supplementation increases xanthine oxidoreductase activity in the kidney and heart but not liver of obese Zucker rats.
Cardiomegaly
Xanthine oxidase inhibitor, febuxostat ameliorates the high salt intake-induced cardiac hypertrophy and fibrosis in Dahl salt-sensitive rats.
Cardiomyopathies
Chronic xanthine oxidase inhibition prevents myofibrillar protein oxidation and preserves cardiac function in a transgenic mouse model of cardiomyopathy.
Cardiomyopathies
Inhibition of xanthine oxidase improves myocardial contractility in patients with ischemic cardiomyopathy.
Cardiomyopathies
The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy.
Cardiomyopathy, Dilated
Chronic xanthine oxidase inhibition prevents myofibrillar protein oxidation and preserves cardiac function in a transgenic mouse model of cardiomyopathy.
Cardiomyopathy, Dilated
Xanthine oxidase inhibition improves left ventricular dysfunction in dilated cardiomyopathic hamsters.
Cardiotoxicity
Experimental Assessment of the Role of Acetaldehyde in Alcoholic Cardiomyopathy.
Cardiotoxicity
Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase.
Cardiotoxicity
Propolis relieves the cardiotoxicity of chlorpyrifos in diabetic rats via alleviations of paraoxonase-1 and xanthine oxidase genes expression.
Cardiotoxicity
Role of xanthine oxidase in the potentiation of doxorubicin-induced cardiotoxicity by mitomycin C.
Cardiotoxicity
Xanthine oxidase inhibition attenuates doxorubicin-induced cardiotoxicity in mice.
Cardiovascular Diseases
Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout.
Cardiovascular Diseases
Cross-Over Trial of Febuxostat and Topiroxostat for Hyperuricemia With Cardiovascular Disease (TROFEO Trial).
Cardiovascular Diseases
Effects of xanthine oxidase inhibitors on cardiovascular disease in patients with gout: a cohort study.
Cardiovascular Diseases
Effects of Xanthine Oxidase Inhibitors on Cardiovascular Disease in Patients with Gout: Ascertaining the Efficacy of Treatment Matters.
Cardiovascular Diseases
Extract from Eugenia punicifolia is an Antioxidant and Inhibits Enzymes Related to Metabolic Syndrome.
Cardiovascular Diseases
Homogenized bovine milk xanthine oxidase: a critique of the hypothesis relating to plasmalogen depletion and cardiovascular disease.
Cardiovascular Diseases
Hyperuricemia and adverse outcomes in cardiovascular disease: potential for therapeutic intervention.
Cardiovascular Diseases
Impact of anti-inflammatory therapies, xanthine oxidase inhibitors and other urate-lowering therapies on cardiovascular diseases in gout.
Cardiovascular Diseases
In-silico Design and ADMET Studies of Natural Compounds as Inhibitors of Xanthine Oxidase (XO) Enzyme.
Cardiovascular Diseases
Long-term inhibition of xanthine oxidase by febuxostat does not decrease blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Cardiovascular Diseases
Major Cardiovascular Events in Patients with Gout and Associated Cardiovascular Disease or Heart Failure and Chronic Kidney Disease Initiating a Xanthine Oxidase Inhibitor.
Cardiovascular Diseases
Plasma Xanthine Oxidase Activity Is Predictive of Cardiovascular Disease in Patients with Chronic Kidney Disease, Independently of Uric Acid Levels.
Cardiovascular Diseases
Prognostic significance of serum uric acid in outpatients with chronic heart failure is complex and related to body mass index: Data from the IN-CHF Registry.
Cardiovascular Diseases
Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat: the PRIZE study.
Cardiovascular Diseases
Synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzo[b]furan derivatives based on salvianolic acid C.
Cardiovascular Diseases
Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives.
Cardiovascular Diseases
The role of urate and xanthine oxidase inhibitors in cardiovascular disease.
Cardiovascular Diseases
Urate-Lowering Drugs and Prevention of Cardiovascular Disease: The Emerging Role of Xanthine Oxidase Inhibition.
Cardiovascular Diseases
Xanthine oxidase activity is associated with risk factors for cardiovascular disease and inflammatory and oxidative status markers in metabolic syndrome: effects of a single exercise session.
Cardiovascular Diseases
Xanthine oxidase and its role as target in cardiovascular disease: cardiovascular protection by enzyme inhibition?
Cardiovascular Diseases
Xanthine oxidase and uric acid in cardiovascular disease: clinical impact and therapeutic options.
Cardiovascular Diseases
Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis.
Cardiovascular Diseases
Xanthine oxidase inhibition for chronic heart failure: is allopurinol the next therapeutic advance in heart failure?
Cardiovascular Diseases
Xanthine Oxidase Inhibition For The Treatment Of Cardiovascular Disease: A Systematic Review and Meta-Analysis.
Cardiovascular Diseases
Xanthine oxidase inhibition for the treatment of cardiovascular disease: a systematic review and meta-analysis.
Cardiovascular Diseases
Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis.
Cardiovascular Diseases
Xanthine oxidase inhibitors are associated with reduced risk of cardiovascular disease.
Cataract
Xanthine oxidase activity in patients with age-related cataract associated with hypertension.
Cataract
Xanthine oxidase and lens oxidative stress markers in diabetic and senile cataract patients.
Celiac Disease
The caffeine metabolic ratio as an index of xanthine oxidase activity in clinically active and silent celiac patients.
Cerebrovascular Disorders
The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease.
Chemical and Drug Induced Liver Injury
Relationship between xanthine oxidase gene polymorphisms and anti-tuberculosis drug-induced liver injury in a Chinese population.
Cholangiocarcinoma
Free radicals enzymatically triggered by Clonorchis sinensis excretory-secretory products cause NF-?B-mediated inflammation in human cholangiocarcinoma cells.
Cholecystitis, Acute
[Dynamics of the cytokines, homocysteine contents, indices of oxydative and nitrosative stress and cytopathic hypoxia in patients after cholecystectomy for acute cholecystitis. Connection with rate of postoperative purulent-inflammatory complications]
Cholera
[The effect of immune antibodies and the xanthine oxidase-xanthine enzymatic link on Vibrio cholerae]
Cholestasis
The impact of hepatic xanthine oxidase and xanthine dehydrogenase activities on liver function in chronic cholestasis.
Cholestasis
[The antioxidant action of dalargin on the liver in experimental acute cholestasis]
Colitis
Febuxostat attenuates ulcerative colitis by the inhibition of NF-?B, proinflammatory cytokines, and oxidative stress in mice.
Colitis
Role of allopurinol and febuxostat in the amelioration of dextran-induced colitis in rats.
Colitis, Ulcerative
Xanthine oxidase activity is not increased in the colonic mucosa of ulcerative colitis.
Colonic Neoplasms
Anticolon Cancer Properties of Pyrazole Derivatives Acting through Xanthine Oxidase Inhibition.
Colonic Neoplasms
Effects of aqueous green tea extract on activities of DNA turn-over enzymes in cancerous and non-cancerous human gastric and colon tissues.
Colonic Neoplasms
Invited review: Bovine milk fat globule membrane as a potential nutraceutical.
Colonic Neoplasms
Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice.
Colorectal Neoplasms
Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing.
Coma
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
Communicable Diseases
Involvement of xanthine oxidase activity with oxidative and inflammatory renal damage in silver catfish experimentally infected with Streptococcus agalactiae: Interplay with reactive oxygen species and nitric oxide.
Communicable Diseases
Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status.
Compartment Syndromes
Inhibition of the compartment syndrome by the ablation of free radical-mediated reperfusion injury.
Compartment Syndromes
Neutrophil mediated microvascular injury in acute, experimental compartment syndrome.
Congenital Abnormalities
Allopurinol-associated hand and foot deformities in chronic tophaceous gout.
Contracture
Depression of peak force without altering calcium sensitivity by the superoxide anion in chemically skinned cardiac muscle of rat.
Contracture
Redox modulation of diaphragm contractility: Interaction between DHPR and RyR channels.
Corneal Endothelial Cell Loss
Morin hydrate: a better protector than purpurogallin of corneal endothelial cell damage induced by xanthine oxidase and SIN-1.
Coronary Artery Disease
Coronary artery superoxide production and nox isoform expression in human coronary artery disease.
Coronary Artery Disease
Purine metabolite-based machine learning models for risk prediction, prognosis, and diagnosis of coronary artery disease.
Coronary Disease
Age-related increase in xanthine oxidase activity in human plasma and rat tissues.
Coronary Disease
Angiotensin II induces endothelial xanthine oxidase activation: role for endothelial dysfunction in patients with coronary disease.
Coronary Disease
Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective.
Coronary Disease
Xanthine oxidase inhibitors the unappreciated treatment for heart failure.
Coronary Occlusion
Does verapamil limit myocardial infarct size in a heart deficient in xanthine oxidase?
Coronary Occlusion
Effects of exogenous oxygen derived free radicals on myocardial capillary permeability, vascular tone, and incidence of ventricular arrhythmias in the canine heart.
Coronary Occlusion
The activity of xanthine oxidase in heart of pigs, guinea pigs, rabbits, rats, and humans.
Craniocerebral Trauma
[Xanthine oxidase of the cerebrospinal fluid in patients with craniocerebral trauma]
Cryptorchidism
Xanthine oxidase inhibitors suppress testicular germ cell apoptosis induced by experimental cryptorchidism.
Cystic Fibrosis
Activities of cytochrome P450 1A2, N-acetyltransferase 2, xanthine oxidase, and cytochrome P450 2D6 are unaltered in children with cystic fibrosis.
Dehydration
Experimental heat stress nephropathy and liver injury are improved by allopurinol.
Demyelinating Diseases
Effects of Venlafaxine, Risperidone and Febuxostat on Cuprizone-Induced Demyelination, Behavioral Deficits and Oxidative Stress.
Dermatitis, Phototoxic
Important role of oxygen metabolites in quinolone antibacterial agent-induced cutaneous phototoxicity in mice.
Diabetes Mellitus
Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study.
Diabetes Mellitus
Chronic hyperglycemia may attenuate the serum-uric-acid-lowering effect of low-dose febuxostat in Japanese patients with type 2 diabetes mellitus.
Diabetes Mellitus
Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4.
Diabetes Mellitus
Effect of Intensive Urate Lowering With Combined Verinurad and Febuxostat on Albuminuria in Patients With Type 2 Diabetes: A Randomized Trial.
Diabetes Mellitus
Elevated Serum Xanthine Oxidase Activity Is Associated With the Development of Type 2 Diabetes: A Prospective Cohort Study.
Diabetes Mellitus
Monotherapy with metformin: does it improve hypoxia in type 2 diabetic patients?
Diabetes Mellitus
Ultrafiltration liquid chromatography combined with high-speed countercurrent chromatography for screening and isolating potential ?-glucosidase and xanthine oxidase inhibitors from Cortex Phellodendri.
Diabetes Mellitus
Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy.
Diabetes Mellitus
Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2.
Diabetes Mellitus
Xanthine Oxidase Inhibitor Allopurinol Prevents Oxidative Stress-Mediated Atrial Remodeling in Alloxan-Induced Diabetes Mellitus Rabbits.
Diabetes Mellitus
[Intervention effect of ganoderma lucidum spores on the changes of XOD, MPO and SDH in the testis tissue of NIDDM rats]
Diabetes Mellitus, Experimental
Influence of insulin status on extra-mitochondrial oxygen metabolism in the rat.
Diabetes Mellitus, Experimental
Xanthine oxidase and D-amino-acid oxidase in fatty liver and alloxan diabetes.
Diabetes Mellitus, Type 1
Impact of intensive insulin treatment on the development and consequences of oxidative stress in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Recent evidence on the effect of urate-lowering treatment on the progression of kidney disease.
Diabetes Mellitus, Type 1
Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol.
Diabetes Mellitus, Type 2
Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study.
Diabetes Mellitus, Type 2
Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension.
Diabetes Mellitus, Type 2
Chronic hyperglycemia may attenuate the serum-uric-acid-lowering effect of low-dose febuxostat in Japanese patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Effect of Intensive Urate Lowering With Combined Verinurad and Febuxostat on Albuminuria in Patients With Type 2 Diabetes: A Randomized Trial.
Diabetes Mellitus, Type 2
Effects of xanthine oxidase inhibition with febuxostat on the development of nephropathy in experimental type 2 diabetes.
Diabetes Mellitus, Type 2
Elevated Serum Xanthine Oxidase Activity Is Associated With the Development of Type 2 Diabetes: A Prospective Cohort Study.
Diabetes Mellitus, Type 2
Erratum. Elevated Serum Xanthine Oxidase Activity Is Associated With the Development of Type 2 Diabetes: A Prospective Cohort Study. Diabetes Care 2018;41;884-890.
Diabetes Mellitus, Type 2
Glycaemic control in relation to xanthine oxidase and antioxidant indices in Malaysian Type 2 diabetes patients.
Diabetes Mellitus, Type 2
Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice.
Diabetes Mellitus, Type 2
Monotherapy with metformin: does it improve hypoxia in type 2 diabetic patients?
Diabetes Mellitus, Type 2
Upregulation of TNF-alpha and Receptors Contribute to Endothelial Dysfunction in Zucker Diabetic Rats.
Diabetes Mellitus, Type 2
Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective.
Diabetes Mellitus, Type 2
Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy.
Diabetic Cardiomyopathies
Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy.
Diabetic Nephropathies
Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction.
Diabetic Nephropathies
Effects of xanthine oxidase inhibition with febuxostat on the development of nephropathy in experimental type 2 diabetes.
Diabetic Nephropathies
Recent evidence on the effect of urate-lowering treatment on the progression of kidney disease.
Diabetic Nephropathies
Targeting oxidative stress and anti-oxidant defence in diabetic kidney disease.
Diabetic Nephropathies
Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice.
Diabetic Neuropathies
Treatment with the xanthine oxidase inhibitor, allopurinol, improves nerve and vascular function in diabetic rats.
Ductus Arteriosus, Patent
Allopurinol protects the bowel from necrosis caused by indomethacin and temporary intestinal ischemia in mice.
Duodenal Ulcer
Histamine, xanthine oxidase generated oxygen-derived free radicals and Helicobacter pylori in gastroduodenal inflammation and ulceration.
Duodenal Ulcer
Role of active oxygen species and lipid peroxidation in mepirizole-induced duodenal ulcers in rats.
Echinococcosis, Hepatic
[Diagnosis and prophylaxis of latent hepatic failure at patients with hepatic echinococcosis]
Encephalomyelitis
Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner.
Encephalomyelitis, Autoimmune, Experimental
Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner.
Endolymphatic Hydrops
Allopurinol attenuates endolymphatic hydrops in the guinea pig cochlea.
Endometrial Hyperplasia
PTEN/PI3K/VEGF signaling pathway involved in the protective effect of xanthine oxidase inhibitor febuxostat against endometrial hyperplasia in rats.
Endometriosis
Xanthine oxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis.
Endotoxemia
Activation of extracellular signal-regulated kinases, NF-kappa B, and cyclic adenosine 5'-monophosphate response element-binding protein in lung neutrophils occurs by differing mechanisms after hemorrhage or endotoxemia.
Endotoxemia
Interactions between CBP, NF-kappaB, and CREB in the lungs after hemorrhage and endotoxemia.
Endotoxemia
Mechanisms of lung neutrophil activation after hemorrhage or endotoxemia: roles of reactive oxygen intermediates, NF-kappa B, and cyclic AMP response element binding protein.
Endotoxemia
Role of increased production of superoxide anions by NAD(P)H oxidase and xanthine oxidase in prolonged endotoxemia.
Endotoxemia
Sesame oil attenuates multiple organ failure and increases survival rate during endotoxemia in rats.
Eosinophilia
Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells.
Epilepsy
Antioxidative-oxidative balance in epilepsy patients on antiepileptic therapy: a prospective case-control study.
Epilepsy
Effects of epilepsy and antiepileptic drugs on nitric oxide, lipid peroxidation and xanthine oxidase system in children with idiopathic epilepsy.
Erythema
Nitric oxide and peroxynitrite released by ultraviolet B-irradiated human endothelial cells are possibly involved in skin erythema and inflammation.
Exanthema
Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells.
Exfoliation Syndrome
The Activities of Paraoxonase, Xanthine Oxidase, Adenosine Deaminase and the Level of Nitrite in Pseudoexfoliation Syndrome.
Familial Primary Pulmonary Hypertension
Increased xanthine oxidase activity in idiopathic pulmonary arterial hypertension.
Fatty Liver
Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats.
Fatty Liver
Dietary nicotinamide supplementation increases xanthine oxidoreductase activity in the kidney and heart but not liver of obese Zucker rats.
Fatty Liver
Simultaneous changes in serum and liver xanthine oxidase and dehydrogenase activities following fatty liver induction.
Fatty Liver
Sodium acetate protects against nicotine-induced excess hepatic lipid in male rats by suppressing xanthine oxidase activity.
Fatty Liver
Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice.
Fibrosarcoma
Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-alpha-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain.
Gastritis
Adenosine deaminase, 5'-nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in gastric juices from patients with gastric cancer, ulcer, and atrophic gastritis.
Gastritis, Atrophic
Adenosine deaminase, 5'-nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in gastric juices from patients with gastric cancer, ulcer, and atrophic gastritis.
Glioblastoma
1'-Acetoxychavicol acetate promotes caspase 3-activated glioblastoma cell death by overcoming enhanced cytokine expression.
Glioblastoma
Augmentation of 5-Aminolevulinic Acid Treatment of Glioblastoma by Adding Ciprofloxacin, Deferiprone, 5-Fluorouracil and Febuxostat: The CAALA Regimen.
Glomerulonephritis
Pivotal role of xanthine oxidase in the initiation of tubulointerstitial renal injury in rats with hyperlipidemia.
Glomerulonephritis, IGA
The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model.
Glomerulonephritis, Membranous
Role of xanthine oxidase in passive Heymann nephritis in rats.
Glucose Intolerance
The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol.
Glycogen Storage Disease Type V
Xanthine oxidase pathway and muscle damage. Insights from McArdle disease.
Gout
3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: A potential therapeutic agent for treatment of hyperuricemia and gout.
Gout
A meta-analysis of the efficacy of allopurinol in reducing the incidence of myocardial infarction following coronary artery bypass grafting.
Gout
A novel xanthine oxidase inhibitor WSJ-557 study on pharmacokinetics and tissue distribution in rats by UPLC-MS/MS.
Gout
A Randomized, Double-Blind, Non-Inferiority Study of Febuxostat Versus Allopurinol in Hyperuricemic Chinese Subjects With or Without Gout.
Gout
A treat-to-target approach for gout confers renoprotective effect in patients with chronic kidney disease stage 3.
Gout
Acute gout flare of bilateral first metatarsophalangeal joints due to ibrutinib use in chronic lymphocytic leukemia.
Gout
Acute kidney injury observed during phase 1 clinical trials of a novel xanthine oxidase/URAT1 dual inhibitor PF-06743649.
Gout
Acute neutropenia associated with initiation of febuxostat therapy for hyperuricaemia in patients with chronic kidney disease.
Gout
Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity.
Gout
Allopurinol attenuates postoperative pain and modulates the purinergic system in patients undergoing abdominal hysterectomy: a randomized controlled trial.
Gout
Allopurinol augmentation in acute mania: A meta-analysis of placebo-controlled trials.
Gout
Allopurinol use and type 2 diabetes incidence among patients with gout: A VA retrospective cohort study.
Gout
An allopurinol-controlled, multicenter, randomized, open-label, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phase 2 exploratory clinical study.
Gout
An allopurinol-controlled, randomized, double-dummy, double-blind, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phase 3 clinical study.
Gout
An in-depth view of potential dual effect of thymol in inhibiting xanthine oxidase activity: Electrochemical measurements in combination with four way PARAFAC analysis and molecular docking insights.
Gout
An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).
Gout
Angiopreventive versus angiopromoting effects of allopurinol in the murine sponge model.
Gout
Anti-Gouty Arthritis and Antihyperuricemia Effects of Sunflower (Helianthus annuus) Head Extract in Gouty and Hyperuricemia Animal Models.
Gout
Anti-inflammatory drugs as new inhibitors to xanthine oxidase: In vitro and in silico approach.
Gout
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.
Gout
Antidepressant-like effects of the xanthine oxidase enzyme inhibitor allopurinol in rats. A comparison with fluoxetine.
Gout
As compared to allopurinol, urate-lowering therapy with febuxostat has superior effects on oxidative stress and pulse wave velocity in patients with severe chronic tophaceous gout.
Gout
Assessment of Cardiovascular Risk in Older Patients with Gout Initiating Febuxostat versus Allopurinol: A Population-Based Cohort Study.
Gout
Cardiovascular events in hyperuricemia population and a cardiovascular benefit-risk assessment of urate-lowering therapies: a systematic review and meta-analysis.
Gout
Cardiovascular safety of febuxostat and allopurinol in patients with gout and cardiovascular comorbidities.
Gout
Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700.
Gout
Comparative efficacy and safety of lesinurad 200 mg and 400 mg combined with a xanthine oxidase inhibitor in hyperuricemic patients with gout: A Bayesian network meta-analysis of randomized controlled trials?.
Gout
Comparison of persistence rates between allopurinol and febuxostat as first-line urate-lowering therapy in patients with gout: an 8-year retrospective cohort study.
Gout
Comparison of pharmacokinetics and uric acid lowering effect between two different strength febuxostat formulations (80 mg vs. 40 mg) in healthy subjects.
Gout
Comprehensive analysis of mechanism underlying hypouricemic effect of glucosyl hesperidin.
Gout
Computational analysis and synthesis of Syringic acid derivatives as Xanthine Oxidase inhibitors.
Gout
Cost-effectiveness analysis of allopurinol versus febuxostat in chronic gout patients: a U.S. payer perspective.
Gout
Design and rationale for the veterans affairs "cooperative study program 594 comparative effectiveness in gout: Allopurinol vs. febuxostat" trial.
Gout
Design and synthesis of novel 2-(indol-5-yl)thiazole derivatives as xanthine oxidase inhibitors.
Gout
Design, synthesis and bioactive evaluation of geniposide derivatives for antihyperuricemic and nephroprotective effects.
Gout
Design, synthesis and biological evaluation of 1-alkyl-5/6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
Gout
Design, synthesis and biological evaluation of novel xanthine oxidase inhibitors bearing a 2-arylbenzo[b]furan scaffold.
Gout
Determination of human plasma xanthine oxidase activity by high-performance liquid chromatography.
Gout
Development and Validation of a Stability-Indicating RP-HPLC Method for the Determination of Febuxostat (a Xanthine Oxidase Inhibitor).
Gout
Development of a method to screen and isolate potential xanthine oxidase inhibitors from Panax japlcus var via ultrafiltration liquid chromatography combined with counter-current chromatography.
Gout
Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout.
Gout
Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors.
Gout
Effects of acupuncture at Shu, Yuan, and Mu acupoints on blood serum uric acid and xanthine oxidase levels in a rat model of gout and hyperuricemia.
Gout
Effects of allopurinol, a xanthine oxidase inhibitor, and sulfinpyrazone upon the urinary and serum urate concentrations in eight patients with tophaceous gout.
Gout
Effects of Food and Antacids on Pharmacokinetics and Pharmacodynamics of Lesinurad, a Selective Urate Reabsorption Inhibitor.
Gout
Effects of lobetyolin on xanthine oxidase activity in vitro and in vivo: weak and mixed inhibition.
Gout
Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers.
Gout
Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout.
Gout
Effects of xanthine oxidase inhibitors on cardiovascular disease in patients with gout: a cohort study.
Gout
Effects of Xanthine Oxidase Inhibitors on Cardiovascular Disease in Patients with Gout: Ascertaining the Efficacy of Treatment Matters.
Gout
Efficacy and safety of allopurinol in patients with hypoxanthine-guanine phosphoribosyltransferase deficiency.
Gout
Efficacy and safety of febuxostat extended release and immediate release in patients with gout and moderate renal impairment: phase II placebo-controlled study.
Gout
Efficacy and Tolerability of Probenecid as Urate-lowering Therapy in Gout; Clinical Experience in High-prevalence Population.
Gout
Electrochemical sensor based on magnetite graphene oxide/ordered mesoporous carbon hybrid to detection of allopurinol in clinical samples.
Gout
Ethanol Extract of Cudrania tricuspidata Leaf Ameliorates Hyperuricemia in Mice via Inhibition of Hepatic and Serum Xanthine Oxidase Activity.
Gout
Evaluation of antigout activity of Phyllanthus emblica fruit extracts on potassium oxonate-induced gout rat model.
Gout
Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and Commonly Used Drugs for Gout Treatment.
Gout
Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and CYP Enzyme Substrates Sildenafil, Amlodipine, Tolbutamide, and Repaglinide.
Gout
Evaluation of xanthine oxidase inhibitory activity of flavonoids by an online capillary electrophoresis-based immobilized enzyme microreactor.
Gout
Excess Deaths Upon Cessation of Xanthine Oxidase Inhibitor Treatment-Data From the Cardiovascular Safety of Febuxostat and Allopurinol in Patients With Gout and Cardiovascular Morbidities Trial: Comment on the Article by Choi et al.
Gout
Fast dereplication of xanthine oxidase-inhibiting compounds in alfalfa using comparative metabolomics.
Gout
Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout.
Gout
Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin.
Gout
Febuxostat-induced agranulocytosis in an end-stage renal disease patient: A case report.
Gout
Febuxostat: a non-purine, selective inhibitor of xanthine oxidase for the management of hyperuricaemia in patients with gout.
Gout
Febuxostat: a novel non-purine selective inhibitor of xanthine oxidase for the treatment of hyperuricemia in gout.
Gout
Febuxostat: A Review of Its Use in the Treatment of Hyperuricaemia in Patients with Gout.
Gout
Febuxostat: a selective xanthine oxidase inhibitor for the treatment of hyperuricemia and gout.
Gout
Febuxostat: a selective xanthine-oxidase/xanthine-dehydrogenase inhibitor for the management of hyperuricemia in adults with gout.
Gout
Flavonoids and Anthranquinones as Xanthine Oxidase and Monoamine Oxidase Inhibitors: A New Approach Towards Inflammation and Oxidative Stress.
Gout
Formulation and Characterization of Febuxostat loaded Nanostructured Lipid Carriers (NLCs) - Gel for Topical Treatment of Gout.
Gout
Formulation and Characterization of Nanosized Ethosomal Formulations of Antigout Model Drug (Febuxostat) Prepared by Cold Method: In Vitro/Ex Vivo and In Vivo Assessment.
Gout
Formulation and in vitro evaluation of fast dissolving tablets of Febuxostat using co-processed excipients.
Gout
Guava leaves polyphenolics-rich extract inhibits vital enzymes implicated in gout and hypertension in vitro.
Gout
High-performance liquid chromatographic determination of hypoxanthine and xanthine in biological fluids.
Gout
Higher Febuxostat Exposure Observed in Asian Compared with Caucasian Subjects Independent of Bodyweight.
Gout
Hispidin, Harmaline, and Harmine as potent inhibitors of bovine xanthine oxidase: Gout treatment, in vitro, ADMET prediction, and SAR studies.
Gout
Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives.
Gout
Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo.
Gout
Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits.
Gout
Impact of anti-inflammatory therapies, xanthine oxidase inhibitors and other urate-lowering therapies on cardiovascular diseases in gout.
Gout
Impact of non-adherence on the safety and efficacy of uric acid lowering therapies in the treatment of gout.
Gout
In silico and 3D QSAR Studies of Natural Based Derivatives as Xanthine oxidase Inhibitors.
Gout
In silico design and synthesis of hesperitin derivatives as new xanthine oxidase inhibitors.
Gout
In silico design and synthesis of targeted rutin derivatives as xanthine oxidase inhibitors.
Gout
In vitro and in silico pharmaceutical activities of the methylated cyclic pentapeptide, persipeptides.
Gout
In vitro xanthine oxidase inhibitory activity of the fractions of Erythrina stricta Roxb.
Gout
In-silico Design and ADMET Studies of Natural Compounds as Inhibitors of Xanthine Oxidase (XO) Enzyme.
Gout
Initiating guideline-concordant gout treatment improves arterial endothelial function and reduces intercritical inflammation: a prospective observational study.
Gout
Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout.
Gout
Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout.
Gout
International position paper on the appropriate use of uricosurics with the introduction of lesinurad.
Gout
Investigation of the interaction between Chrysoeriol and xanthine oxidase using computational and in vitro approaches.
Gout
Investigation of the interaction between salvianolic acid C and xanthine oxidase: Insights from experimental studies merging with molecular docking methods.
Gout
Kinetic study on the inhibition of xanthine oxidase by extracts from two selected Algerian plants traditionally used for the treatment of inflammatory diseases.
Gout
Lanthanide (III) complexes of bis-coumarins as strong inhibitors of bovine xanthine oxidase - molecular docking and SAR studies.
Gout
Lesinurad Combined With Allopurinol: Randomized, Double-Blind, Placebo-Controlled Study in Gout Subjects With Inadequate Response to Standard of Care Allopurinol (A US-based Study).
Gout
Lesinurad monotherapy in gout patients intolerant to a xanthine oxidase inhibitor: a 6 month phase 3 clinical trial and extension study.
Gout
Lesinurad, a Selective URAT-1 Inhibitor With a Novel Mechanism in Combination With a Xanthine Oxidase Inhibitor, for Hyperuricemia Associated With Gout.
Gout
Lesinurad: A significant advancement or just another addition to existing therapies of gout?
Gout
Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers.
Gout
Longan Seed Extract Reduces Hyperuricemia via Modulating Urate Transporters and Suppressing Xanthine Oxidase Activity.
Gout
Major Cardiovascular Events in Patients with Gout and Associated Cardiovascular Disease or Heart Failure and Chronic Kidney Disease Initiating a Xanthine Oxidase Inhibitor.
Gout
Mechanistic approach towards interaction of newly synthesized Hesperidin derivatives against xanthine oxidase.
Gout
Modeling and optimizing inhibitory activities of Nelumbinis folium extract on xanthine oxidase using response surface methodology.
Gout
Molecular Dockings and Molecular Dynamics Simulations Reveal the Potency of Different Inhibitors against Xanthine Oxidase.
Gout
Mori Ramulus (Chin.Ph.)-the Dried Twigs of Morus alba L./Part 1: Discovery of Two Novel Coumarin Glycosides from the Anti-Hyperuricemic Ethanol Extract.
Gout
Multicenter, open-label study of long-term administration of febuxostat (TMX-67) in Japanese patients with hyperuricemia including gout.
Gout
Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study.
Gout
Nickel-Catalyzed C?H Arylation of Azoles with Haloarenes: Scope, Mechanism, and Applications to the Synthesis of Bioactive Molecules.
Gout
Novel 3-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1,2,4-oxadiazol-5(4H)-ones as promising xanthine oxidase inhibitors: Design, synthesis and biological evaluation.
Gout
Novel thiazolo-pyrazolyl derivatives as xanthine oxidase inhibitors and free radical scavengers.
Gout
Oral Treatment With an Engineered Uricase, ALLN-346, Reduces Hyperuricemia, and Uricosuria in Urate Oxidase-Deficient Mice.
Gout
Oxidative coupling of epigallocatechin gallate amplifies antioxidant activity and inhibits xanthine oxidase activity.
Gout
Patient considerations in the management of gout and role of combination treatment with lesinurad.
Gout
Pegloticase in gout treatment - safety issues, latest evidence and clinical considerations.
Gout
Pharmacokinetics and tolerability of febuxostat after oral administration in healthy Chinese volunteers: a randomized, open-label, singleand multiple-dose three-way crossover study.
Gout
Pharmacokinetics, pharmacodynamics and safety of febuxostat, a non-purine selective inhibitor of xanthine oxidase, in a dose escalation study in healthy subjects.
Gout
Pharmacokinetics, pharmacodynamics, and tolerability of LC350189, a novel xanthine oxidase inhibitor, in healthy subjects.
Gout
Pharmacophore modeling, molecular docking and molecular dynamics studies on natural products database to discover novel skeleton as non-purine xanthine oxidase inhibitors.
Gout
Phosphorescent inner filter effect-based sensing of xanthine oxidase and its inhibitors with Mn-doped ZnS quantum dots.
Gout
Physicochemical Stability of Compounded Allopurinol Suspensions in PCCA Base, SuspendIt.
Gout
Phytochemical investigation of some traditional chinese medicines and endophyte cultures.
Gout
Placebo-controlled double-blind dose-response study of the non-purine-selective xanthine oxidase inhibitor febuxostat (TMX-67) in patients with hyperuricemia (including gout patients) in japan: late phase 2 clinical study.
Gout
Placebo-controlled, double-blind study of the non-purine-selective xanthine oxidase inhibitor Febuxostat (TMX-67) in patients with hyperuricemia including those with gout in Japan: phase 3 clinical study.
Gout
Plumbagin can potently enhance the activity of xanthine oxidase: in vitro, in vivo and in silico studies.
Gout
Protocol of the Febuxostat versus Allopurinol Streamlined Trial (FAST): a large prospective, randomised, open, blinded endpoint study comparing the cardiovascular safety of allopurinol and febuxostat in the management of symptomatic hyperuricaemia.
Gout
Rapid and reliable HILIC-MS/MS method for monitoring allantoin as a biomarker of oxidative stress.
Gout
Rapid characterisation of xanthine oxidase inhibitors from the flowers of Chrysanthemum morifolium Ramat. Using metabolomics approach.
Gout
Rapid screening and detection of XOD inhibitors from S. tamariscina by ultrafiltration LC-PDA-ESI-MS combined with HPCCC.
Gout
Rhaponticum acaule (L) DC essential oil: chemical composition, in vitro antioxidant and enzyme inhibition properties.
Gout
Role of Community Pharmacies for the Detection of Potentially Inappropriate Xanthine Oxidase Inhibitor Prescriptions.
Gout
Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress.
Gout
Safety and Efficacy of Febuxostat Treatment in Subjects with Gout and Severe Allopurinol Adverse Reactions.
Gout
Screening and determination of potential xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae using ultrafiltration liquid chromatography-mass spectrometry.
Gout
Screening for selective inhibitors of xanthine oxidase from Flos Chrysanthemum using ultrafiltration LC-MS combined with enzyme channel blocking.
Gout
Screening of Potential Xanthine Oxidase Inhibitors in Gnaphalium hypoleucum DC. by Immobilized Metal Affinity Chromatography and Ultrafiltration-Ultra Performance Liquid Chromatography-Mass Spectrometry.
Gout
Screening of xanthine oxidase inhibitors in complex mixtures using online HPLC coupled with postcolumn fluorescence-based biochemical detection.
Gout
Screening, separation, and evaluation of xanthine oxidase inhibitors from Paeonia lactiflora using chromatography combined with a multi-mode microplate reader.
Gout
Second-line treatment with lesinurad and allopurinol versus febuxostat for management of hyperuricemia: a cost-effectiveness analysis for Spanish patients.
Gout
Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase.
Gout
Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol.
Gout
Spectroscopic and molecular structure (monomeric and dimeric model) investigation of Febuxostat: A combined experimental and theoretical study.
Gout
Spectrum-effect relationship between high-performance thin-layer chromatography data and xanthine oxidase inhibitory activity of celery seed extract.
Gout
Structure-activity relationship of caffeic acid analogues on xanthine oxidase inhibition.
Gout
Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors.
Gout
Successful treatment of refractory gout using combined therapy consisting of febuxostat and allopurinol in a patient with chronic renal failure.
Gout
Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study.
Gout
Synthesis and biological activity of pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one derivatives: in silico approach.
Gout
Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.
Gout
Synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzo[b]furan derivatives based on salvianolic acid C.
Gout
Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives.
Gout
Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors.
Gout
Synthesis, Antioxidant, and Xanthine Oxidase Inhibitory Activities of 5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione Derivatives.
Gout
Synthesis, molecular docking and xanthine oxidase inhibitory activity of 5-aryl-1H-tetrazoles.
Gout
Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.
Gout
Tetrahydroamentoflavone (THA) from Semecarpus anacardium as a potent inhibitor of xanthine oxidase.
Gout
The effect of age and gender on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase.
Gout
The Effect of Lesinurad in Combination With Allopurinol on Serum Uric Acid Levels in Patients With Gout.
Gout
THE EFFECTIVENESS OF THE XANTHINE OXIDASE INHIBITOR ALLOPURINOL IN THE TREATMENT OF GOUT.
Gout
The Encapsulation of Febuxostat into Emulsomes Strongly Enhances the Cytotoxic Potential of the Drug on HCT 116 Colon Cancer Cells.
Gout
The inhibitory kinetics and mechanism of dietary vitamins D3 and B2 on xanthine oxidase.
Gout
The Role of Xanthine Oxidase Inhibitors in Patients with History of Stroke: A Systematic Review.
Gout
The use of the xanthine oxidase inhibitor, allopurinol, in the control of hyperuricaemia, gout and uric acid calculi.
Gout
Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol.
Gout
Ultrafiltration liquid chromatography combined with high-speed countercurrent chromatography for screening and isolating potential ?-glucosidase and xanthine oxidase inhibitors from Cortex Phellodendri.
Gout
Ultrahigh performance liquid chromatography-triple quadrupole mass spectrometry inhibitors fishing assay: a novel method for simultaneously screening of xanthine oxidase inhibitor and superoxide anion scavenger in a single analysis.
Gout
Use of newly available febuxostat in a case of chronic tophaceous gout contraindicated to allopurinol and probenecid.
Gout
Using analytical multidimensional isocratic HPLC methods of separation to isolate active constituents in natural products.
Gout
Utilization of acute gout prophylaxis in the real world: a retrospective database cohort analysis.
Gout
Various machine learning approaches coupled with molecule simulation in the screening of natural compounds with xanthine oxidase inhibitory activity.
Gout
Virtual and In vitro bioassay screening of phytochemical inhibitors from flavonoids and isoflavones against Xanthine oxidase and Cyclooxygenase-2 for gout treatment.
Gout
Virtual and In Vitro Bioassay Screening of Phytochemical Inhibitors from Flavonoids and Isoflavones Against Xanthine Oxidase and Cyclooxygenase-2 for Gout Treatment.
Gout
Virtual Screening Analysis and In-vitro Xanthine Oxidase Inhibitory Activity of Some Commercially Available Flavonoids.
Gout
X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin.
Gout
Xanthine Oxidase and Transforming Growth Factor Beta-activated Kinase 1: Potential Targets for Gout Intervention.
Gout
Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout.
Gout
Xanthine oxidase inhibitory activity of the methanolic extracts of selected Jordanian medicinal plants.
Gout
Xanthine Oxidase Inhibitory Activity, Chemical Composition, Antioxidant Properties and GC-MS Analysis of Keladi Candik (Alocasia longiloba Miq).
Gout
Xanthine oxidase inhibitory peptides derived from tuna protein: virtual screening, inhibitory activity, and molecular mechanisms.
Gout
[A family of hereditary xanthinuria: two siblings with peptic ulcer and hypouricemia due to xanthine oxidase deficiency, and a heterozygote (father) with gout]
Gout
[Design, synthesis and biological evaluation of oxadiazole derivatives as xanthine oxidase inhibitors].
Gout
[Early results obtained with the use of the xanthine oxidase inhibitor (4-hydroxypyrazol-pyrimidine) in gout. Preliminary note]
Gout
[ERRORS IN THE DIAGNOSTICS AND TREATMENT OF PATIENTS WITH GOUT AND THE ALGORITHM OF THERAPEUTIC TACTICS IN DIFFERENT PERIODS OF THE DISEASE (CLINICAL CASE)].
Gout
[Purine metabolism enzymes in diagnosis and differential diagnosis of osteoarthritis and gout arthritis]
Gout
[Treatment of gout with the combination of xanthine oxidase inhibitors and uricosuric agents]
Granuloma
[Xanthine oxidase activity: NAD+-dependent and O2-dependent forms in carrageenan granuloma in the rat]
Granulomatous Disease, Chronic
Xanthine oxidase contributes to host defense against Burkholderia cepacia in the p47(phox-/-) mouse model of chronic granulomatous disease.
Graves Disease
Changes in free radical scavengers and lipid peroxide in thyroid glands of various thyroid disorders.
Head and Neck Neoplasms
Adenosine deaminase, xanthine oxidase, superoxide dismutase, glutathione peroxidase activities and malondialdehyde levels in the sera of patients with head and neck carcinoma.
Heart Arrest
Effect of normothermic ischemic cardiac arrest and of reperfusion on the free oxygen radical scavenger enzymes and xanthine oxidase (a generator of superoxide anions).
Heart Diseases
Homogenized bovine milk xanthine oxidase: a critique of the hypothesis relating to plasmalogen depletion and cardiovascular disease.
Heart Diseases
Immunobiochemical analysis of Paraoxonase1 (anti-oxidant), xanthine oxidase (oxidant) enzymes and lipid profile of cardiac disease patients in Lahore Metropolitan, Pakistan.
Heart Failure
Acute effects of febuxostat, a nonpurine selective inhibitor of xanthine oxidase, in pacing induced heart failure.
Heart Failure
Age-related increase in xanthine oxidase activity in human plasma and rat tissues.
Heart Failure
Allopurinol acutely increases adenosine triphospate energy delivery in failing human hearts.
Heart Failure
Allopurinol attenuates left ventricular remodeling and dysfunction after experimental myocardial infarction: a new action for an old drug?
Heart Failure
Allopurinol enhances the contractile response to dobutamine and exercise in dogs with pacing-induced heart failure.
Heart Failure
Association between long-term prescription of febuxostat and the progression of heart failure with preserved ejection fraction in patients with hypertension and asymptomatic hyperuricemia.
Heart Failure
Associations of methyl donor and methylation inhibitor levels during anti-oxidant therapy in heart failure.
Heart Failure
Chronic allopurinol administration ameliorates maladaptive alterations in Ca2+ cycling proteins and beta-adrenergic hyporesponsiveness in heart failure.
Heart Failure
Chronic treatment with allopurinol boosts survival and cardiac contractility in murine postischemic cardiomyopathy.
Heart Failure
Chronic xanthine oxidase inhibition prevents myofibrillar protein oxidation and preserves cardiac function in a transgenic mouse model of cardiomyopathy.
Heart Failure
Effect of Allopurinol on Myocardial Energy Metabolism in Chronic Heart Failure Rats After Myocardial Infarct.
Heart Failure
Effect of Xanthine Oxidase Inhibition on Arterial Stiffness in Patients With Chronic Heart Failure.
Heart Failure
Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study.
Heart Failure
Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies.
Heart Failure
Excess purine degradation caused by an imbalance in the supply of adenosine triphosphate in patients with congestive heart failure.
Heart Failure
Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study.
Heart Failure
Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failure.
Heart Failure
Inhibition of xanthine oxidase improves myocardial contractility in patients with ischemic cardiomyopathy.
Heart Failure
Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance.
Heart Failure
Kidney Function, Nutritional Status, and the Left Ventricle Dysfunction Are Associated with Serum Uric Acid Levels in Patients with Heart Failure with Reduced Ejection Fraction.
Heart Failure
LB01.10: EFFECT OF XANTHINE OXIDASE INHIBITION ON ARTERIAL STIFFNESS IN PATIENTS WITH CHRONIC HEART FAILURE.
Heart Failure
Major Cardiovascular Events in Patients with Gout and Associated Cardiovascular Disease or Heart Failure and Chronic Kidney Disease Initiating a Xanthine Oxidase Inhibitor.
Heart Failure
Randomized Trial of Effect of Urate-Lowering Agent Febuxostat in Chronic Heart Failure Patients with Hyperuricemia (LEAF-CHF).
Heart Failure
Rationale, design and organisation of an efficacy and safety study of oxypurinol added to standard therapy in patients with NYHA class III - IV congestive heart failure.
Heart Failure
Reactive oxygen species signalling in the diabetic heart: emerging prospect for therapeutic targeting.
Heart Failure
Serum level of uric acid, partly secreted from the failing heart, is a prognostic marker in patients with congestive heart failure.
Heart Failure
Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort study.
Heart Failure
Sildenafil protects epithelial cell through the inhibition of xanthine oxidase and the impairment of ROS production.
Heart Failure
The effect of xanthine oxidase inhibition upon ejection fraction in heart failure patients: La Plata Study.
Heart Failure
The effects of xanthine oxidase inhibitor in patients with chronic heart failure complicated with hyperuricemia: a prospective randomized controlled clinical trial of topiroxostat vs allopurinol-study protocol.
Heart Failure
The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy.
Heart Failure
Uric acid and xanthine oxidase in heart failure - Emerging data and therapeutic implications.
Heart Failure
Uric acid in cachectic and noncachectic patients with chronic heart failure: relationship to leg vascular resistance.
Heart Failure
Uric Acid Is a Biomarker of Oxidative Stress in the Failing Heart: Lessons Learned from Trials With Allopurinol and SGLT2 Inhibitors.
Heart Failure
Uric acid predicts clinical outcomes in heart failure: insights regarding the role of xanthine oxidase and uric acid in disease pathophysiology.
Heart Failure
Uric acid, heart failure survival, and the impact of xanthine oxidase inhibition.
Heart Failure
Xanthine oxidase inhibition ameliorates cardiovascular dysfunction in dogs with pacing-induced heart failure.
Heart Failure
Xanthine oxidase inhibition and heart failure: novel therapeutic strategy for ventricular dysfunction?
Heart Failure
Xanthine oxidase inhibition for chronic heart failure: is allopurinol the next therapeutic advance in heart failure?
Heart Failure
Xanthine oxidase inhibition for hyperuricemic heart failure patients: design and rationale of the EXACT-HF study.
Heart Failure
Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice.
Heart Failure
Xanthine oxidase inhibitors improve energetics and function after infarction in failing mouse hearts.
Heart Failure
Xanthine oxidase inhibitors in elderly patients with heart failure: useful or useless?
Heart Failure
[Effect of concomitant chronic kidney disease on the xanthine metabolism in patients with chronic heart failure].
Heart Failure, Systolic
Uric acid level and allopurinol use as risk markers of mortality and morbidity in systolic heart failure.
Hematologic Neoplasms
A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly sensitive assay.
Hematologic Neoplasms
Controlling serum uric acid using febuxostat in cancer patients at risk of tumor lysis syndrome.
Hematologic Neoplasms
Febuxostat for management of tumor lysis syndrome including its effects on levels of purine metabolites in patients with hematological malignancies - a single institution's, pharmacokinetic and pilot prospective study.
Hematologic Neoplasms
Prevention and treatment of hyperuricemia in hematological malignancies.
Hemochromatosis
Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2.
Hemorrhagic Fever, Crimean
Determination of serum adenosine deaminase and xanthine oxidase levels in patients with crimean-congo hemorrhagic fever.
Hemorrhagic Stroke
Plasma values of oxidants and antioxidants in acute brain hemorrhage: role of free radicals in the development of brain injury.
Hepatitis
A link between extracellular reactive oxygen and endotoxin-induced release of tumour necrosis factor alpha in vivo.
Hepatitis
Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin.
Hepatitis
Diagnostic value of determination of serum xanthine oxidase activity in acute viral hepatitis.
Hepatitis
Oxidation of circulating proteins in alcoholics: role of acetaldehyde and xanthine oxidase.
Hepatitis
Structure-activity relationship of caffeic acid analogues on xanthine oxidase inhibition.
Hepatitis
Xanthine oxidase in serum of viral hepatitis patients may interfere in urate determination by endpoint measurement with xanthine in the reagent mixture.
Hepatitis
[Xanthine oxidase activity: O2-dependent and NAD+-dependent forms in the liver, in rats with adjuvant arthritis and hepatitis]
Hepatitis C
Determination of human plasma xanthine oxidase activity by high-performance liquid chromatography.
Hepatolenticular Degeneration
Iron depletion prevents adenine nucleotide decomposition and an increase of xanthine oxidase activity in the liver of the Long Evans Cinnamon (LEC) rat, an animal model of Wilson's disease.
Hypercholesterolemia
Hypercholesterolemia increases endothelial superoxide anion production.
Hypercholesterolemia
L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemia.
Hypercholesterolemia
The Crucial Role of Xanthine Oxidase in CKD Progression Associated with Hypercholesterolemia.
Hypercholesterolemia
The emerging role of xanthine oxidase inhibition for suppression of breast cancer cell migration and metastasis associated with hypercholesterolemia.
Hyperglycemia
Exposure of human keratinocytes to ischemia, hyperglycemia and their combination induces oxidative stress via the enzymes inducible nitric oxide synthase and xanthine oxidase.
Hyperglycemia
Metabonomics revealed xanthine oxidase-induced oxidative stress and inflammation in the pathogenesis of diabetic nephropathy.
Hyperglycemia
Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction.
Hyperinsulinism
Effects of Body Mass Index, Glycemic Control, and Hypoglycemic Drugs on Serum Uric Acid Levels in Type 2 Diabetic Patients.
Hyperlipidemia, Familial Combined
Increased plasma xanthine oxidase activity is related to nuclear factor kappa beta activation and inflammatory markers in familial combined hyperlipidemia.
Hyperlipidemias
Effect of febuxostat on biochemical parameters of hyperlipidemia induced by a high-fat diet in rabbits.
Hyperlipidemias
Increased plasma xanthine oxidase activity is related to nuclear factor kappa beta activation and inflammatory markers in familial combined hyperlipidemia.
Hyperlipidemias
Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction.
Hyperlipidemias
Pivotal role of xanthine oxidase in the initiation of tubulointerstitial renal injury in rats with hyperlipidemia.
Hyperlipidemias
Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond.
Hyperlipidemias
Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet.
Hyperlipoproteinemia Type IV
Xanthine oxidase and triglycerides in serum of patients with hyperlipoproteinemia, type IV.
Hyperlipoproteinemias
Xanthine oxidase and triglycerides in serum of patients with hyperlipoproteinemia, type IV.
Hyperoxaluria
Calcium oxalate precipitation in urine following T.U.R. with glycine as irrigation fluid.
Hypertension
Allopurinol does not Decrease Blood Pressure or Prevent the Development of Hypertension in the Doca-Salt Rat Model.
Hypertension
Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension.
Hypertension
Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9.
Hypertension
Effect of Febuxostat on Ambulatory Blood Pressure in Subjects With Hyperuricemia and Hypertension: A Phase 2 Randomized Placebo-Controlled Study.
Hypertension
Effect of Febuxostat, a Xanthine Oxidase Inhibitor, on Cardiovascular Risk in Hyperuricemic Patients with Hypertension: A Prospective, Open-label, Pilot Study.
Hypertension
Effect of hydrochlorothiazide on the pharmacokinetics and pharmacodynamics of febuxostat, a non-purine selective inhibitor of xanthine oxidase.
Hypertension
Effects of allopurinol, a xanthine oxidase inhibitor, on renal injury in hypercholesterolemia-induced hypertensive rats.
Hypertension
Effects of losartan and allopurinol on cardiorespiratory regulation in obstructive sleep apnoea.
Hypertension
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
Hypertension
Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms.
Hypertension
Guava leaves polyphenolics-rich extract inhibits vital enzymes implicated in gout and hypertension in vitro.
Hypertension
Increased xanthine oxidase activity in idiopathic pulmonary arterial hypertension.
Hypertension
Inhibitory influences of xanthine oxidase inhibitor and angiotensin I-converting enzyme inhibitor on multinucleated giant cell formation from monocytes by downregulation of adhesion molecules and purinergic receptors.
Hypertension
Long-term inhibition of xanthine oxidase by febuxostat does not decrease blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Hypertension
Nicardipine normalizes elevated levels of antioxidant activity in response to xanthine oxidase-induced oxidative stress in hypertensive rat heart.
Hypertension
Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertension.
Hypertension
Protective effects of therapy with a protease and xanthine oxidase inhibitor in short form pancreatic biliary obstruction and ischemia in rats.
Hypertension
Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond.
Hypertension
Renal denervation attenuates hypertension and renal dysfunction in a model of cardiovascular and renal disease, which is associated with reduced NADPH and xanthine oxidase activity.
Hypertension
Response to ischemia-reperfusion injury in hypertrophic heart. Role of free-radical metabolic pathways.
Hypertension
Signaling pathways of mechanotransduction in arteriolar endothelium and smooth muscle cells in hypertension.
Hypertension
The inflammatory aspect of the microcirculation in hypertension: oxidative stress, leukocytes/endothelial interaction, apoptosis.
Hypertension
The relationship between hypertension and plasma allantoin, uric acid, xanthine oxidase activity and nitrite, and their predictive capacity in severe preeclampsia.
Hypertension
The release of the substrate for xanthine oxidase in hypertensive patients was suppressed by angiotensin converting enzyme inhibitors and alpha1-blockers.
Hypertension
Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia.
Hypertension
Uric acid, xanthine oxidase and other risk factors of hypertension in normotensive subjects.
Hypertension
Vascular endothelium dysfunction: a conservative target in metabolic disorders.
Hypertension
Vascular Structure and Oxidative Stress in Salt-Loaded Spontaneously Hypertensive Rats: Effects of Losartan and Atenolol.
Hypertension
Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity.
Hypertension
Xanthine oxidase activity associated with arterial blood pressure in spontaneously hypertensive rats.
Hypertension
Xanthine oxidase activity in patients with age-related cataract associated with hypertension.
Hypertension
Xanthine oxidase gene variants and their association with blood pressure and incident hypertension: a population study.
Hypertension
Xanthine Oxidase Inhibition as a Potential Treatment for Aortic Stiffness in Hypertension.
Hypertension, Pregnancy-Induced
Xanthine oxidase activation in mild gestational hypertension.
Hypertension, Pulmonary
Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats.
Hypertension, Pulmonary
Reactive oxygen species and RhoA signaling in vascular smooth muscle: role in chronic hypoxia-induced pulmonary hypertension.
Hypertension, Pulmonary
[D-penicillamine: old drug, new indication? D-penicillamine reduced pulmonary hypertension induced by free radicals]
Hyperthyroidism
Lipid peroxidation levels in rat cardiac muscle are affected by age and thyroid status.
Hyperthyroidism
The role of allopurinol on oxidative stress in experimental hyperthyroidism.
Hypertrophy, Left Ventricular
Allopurinol is an independent determinant of improved arterial stiffness in chronic kidney disease: a cross-sectional study.
Hypertrophy, Left Ventricular
Association between long-term prescription of febuxostat and the progression of heart failure with preserved ejection fraction in patients with hypertension and asymptomatic hyperuricemia.
Hypertrophy, Left Ventricular
Delayed treatment effects of xanthine oxidase inhibition on systolic overload-induced left ventricular hypertrophy and dysfunction.
Hypertrophy, Left Ventricular
Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertension.
Hypertrophy, Left Ventricular
Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective.
Hypertrophy, Left Ventricular
Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice.
Hypoplastic Left Heart Syndrome
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
Hypoplastic Left Heart Syndrome
The pharmacokinetics of injectable allopurinol in newborns with the hypoplastic left heart syndrome.
Hypotension
Studies on the oxygen radical mechanism involved in the small intestinal reperfusion damage.
Hypotension
The effect of allopurinol and catalase on cardiovascular hemodynamics during hemorrhagic shock.
Hypotension
Zonal heterogeneity of hepatic injury following shock/resuscitation: relationship of xanthine oxidase activity to localization of neutrophil accumulation and central lobular necrosis.
Hypothyroidism
Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase.
hypoxanthine phosphoribosyltransferase deficiency
Two-dimensional thin-layer chromatography for the screening of disorders of purine and pyrimidine metabolism.
Hypoxia, Brain
Effect of allopurinol on hypoxia-induced modification of the NMDA receptor in newborn piglets.
Hypoxia-Ischemia, Brain
Xanthine oxidase does not contribute to apoptosis after brain hypoxia-ischemia in immature rabbits.
Idiopathic Pulmonary Fibrosis
Inducible nitric oxide synthase, but not xanthine oxidase, is highly expressed in interstitial pneumonias and granulomatous diseases of human lung.
IgA Vasculitis
Elevated serum xanthine oxidase activities in patients with Henoch-Schonlein purpura.
Infant, Newborn, Diseases
Contribution of oxygen-derived free radicals to experimental necrotizing enterocolitis.
Infarction, Middle Cerebral Artery
The effect of allopurinol on focal cerebral ischaemia: an experimental study in rabbits.
Infections
Antioxidant activities of some tryptophan metabolites: possible implication for inflammatory diseases.
Infections
Changes in hepatic superoxide dismutase and xanthine oxidase activity in mice infected with Salmonella typhimurium and Pseudomonas aeruginosa.
Infections
Effect of poly ICLC treatment on hepatic oxidative stress and antioxidant defense indices in Plasmodium yoelii nigeriensis infected mice.
Infections
Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers.
Infections
Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice.
Infections
Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice.
Infections
Influence of cortisone and cyclophosphamide on xanthine oxidase bacterial activation.
Infections
Inhibition of uric acid or IL-1? ameliorates respiratory syncytial virus immunopathology and development of asthma.
Infections
Levels and interactions of plasma xanthine oxidase, catalase and liver function parameters in Nigerian children with Plasmodium falciparum infection.
Infections
New markers: urine xanthine oxidase and myeloperoxidase in the early detection of urinary tract infection.
Infections
Oxidants and antioxidants in viral diseases: disease mechanisms and metabolic regulation.
Infections
Pathogenesis of cytomegalovirus-associated pneumonitis in ICR mice: possible involvement of superoxide radicals.
Infections
Role of Host Xanthine Oxidase in Infection Due to Enteropathogenic and Shiga-Toxigenic Escherichia coli.
Infections
Role of host xanthine oxidase in infection due to enteropathogenic and Shiga-toxigenic Escherichia coli.
Infections
Status of hepatic oxidative stress and antioxidant defense systems during chloroquine treatment of Plasmodium yoelii nigeriensis infected mice.
Infections
Studies on hepatic oxidative stress and antioxidant defence system during chloroquine/poly ICLC treatment of Plasmodium yoelii nigeriensis infected mice.
Infections
Studies on hepatic oxidative stress and antioxidant defence systems during arteether treatment of Plasmodium yoelii nigeriensis infected mice.
Infections
The effect of Panax notoginseng saponins on oxidative stress induced by PCV2 infection in immune cells: in vitro and in vivo studies.
Infections
The effects of increased cAMP content on inflammation, oxidative stress and PDE4 transcripts during Brucella melitensis infection.
Infections
The link between infection and cancer: Tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect.
Infections
Xanthine oxidase, superoxide dismutase, catalase and lipid peroxidation in Mastomys natalensis: effect of Dipetalonema viteae infection.
Infections
[Deleterious pathogenic mechanism involving host response in influenza virus infection in mice]
Infertility, Male
Effect of reactive oxygen species and the activity of antioxidant systems on human semen; association with male infertility.
Infertility, Male
Xanthine oxidase inhibitors suppress testicular germ cell apoptosis induced by experimental cryptorchidism.
Inflammatory Bowel Diseases
Limited intra-individual variability in hypoxanthine-Guanine phosphoribosyl transferase, thiopurine S-methyl transferase, and xanthine oxidase activity in inflammatory bowel disease patients during 6-thioguanine therapy.
Inflammatory Bowel Diseases
Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases.
Inflammatory Bowel Diseases
Xanthine oxidase activity in thiopurine curative Chinese inflammatory bowel disease patients.
Influenza, Human
Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice.
Influenza, Human
Effect of Wen-Pi-Tang extract on lung damage by influenza virus infection.
Influenza, Human
Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD.
Influenza, Human
Protective effect of n-acetylcysteine in a model of influenza infection in mice.
Insulin Resistance
Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study.
Insulin Resistance
Dapagliflozin and xanthine oxidase inhibitors improve insulin resistance and modulate renal glucose and urate transport in metabolic syndrome.
Insulin Resistance
Insulin resistance and depressed cardiac G6PD activity induced by glucocorticoid exposure during pregnancy are attenuated by maternal estrogen-progestin therapy.
Insulin Resistance
Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction.
Insulin Resistance
Suppression of uric acid and lactate production by sodium acetate ameliorates hepatic triglyceride accumulation in fructose-insulin resistant pregnant rats.
Insulin Resistance
Uric Acid promotes left ventricular diastolic dysfunction in mice fed a Western diet.
Insulin Resistance
Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system.
Insulin Resistance
Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice.
Intermittent Claudication
Oster rediscovered--mega-dose folate for symptomatic atherosclerosis.
Intracranial Aneurysm
Increased oxidative stress and xanthine oxidase activity in human ruptured cerebral aneurysms.
Iron Deficiencies
Effect of molybdenum-deficient and low iron diets on xanthine oxidase activity and iron status in rats.
Iron Overload
Evidence that iron-overload promotes 7,12-dimethylbenz(a)anthracene- induced skin tumorigenesis in mice.
Ischemic Stroke
Superoxide dismutase activity in serum of patients with acute cerebral ischemic injury. Correlation with clinical course and infarct size.
Ischemic Stroke
Xanthine oxidase inhibition for the improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) - Protocol for a randomised double blind placebo-controlled clinical trial.
Keloid
[Activity detection and immunohistochemistry study on xanthine oxidase in pathological scars]
Ketosis
Procedures for microencapsulation of enzymes, cells and genetically engineered microorganisms.
Kidney Calculi
Allopurinol and loss of consciousness in a 78-old year man suffering from gout.
Kidney Calculi
Association of Serum Uric Acid and Incident Nonspine Fractures in Elderly Men: The Osteoporotic Fractures in Men (MrOS) Study.
Kidney Diseases
Recent evidence on the effect of urate-lowering treatment on the progression of kidney disease.
Kidney Diseases
Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study.
Kidney Failure, Chronic
Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice.
Lesch-Nyhan Syndrome
Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection.
Lesch-Nyhan Syndrome
Microencapsulated xanthine oxidase as experimental therapy in Lesch-Nyhan disease.
Lesch-Nyhan Syndrome
Procedures for microencapsulation of enzymes, cells and genetically engineered microorganisms.
Leukemia
Antioxidative, antimutagenic, and anticarcinogenic activities of rice bran extracts in chemical and cell assays.
Leukemia
Cocoa Polyphenols Inhibit Phorbol Ester-Induced Superoxide Anion Formation in Cultured HL-60 Cells and Expression of Cyclooxygenase-2 and Activation of NF-{kappa}B and MAPKs in Mouse Skin In Vivo.
Leukemia
Identification and antioxidant activity of novel chlorogenic acid derivatives from bamboo (Phyllostachys edulis).
Leukemia
Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis x-mediated cell adhesion.
Leukemia
Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer.
Leukemia
PREVENTION OF HYPERURICEMIA IN LEUKEMIA AND LYMPHOMA: USE OF ALOPURINOL, A XANTHINE OXIDASE INHIBITOR.
Leukemia
Xanthine oxidase inhibition in the management of hyperuricemia in leukemias and lymphomas.
Leukemia
Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.
Leukemia, Promyelocytic, Acute
Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.
Leukopenia
Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation.
Leukopenia
Thiopurine therapies: problems, complexities, and progress with monitoring thioguanine nucleotides.
Leukostasis
Xanthine oxidase and superoxide radicals in portal triad crossclamping-induced microvascular reperfusion injury of the liver.
Liver Cirrhosis
Liver cirrhosis induced by carbon tetrachloride and the effect of superoxide dismutase and xanthine oxidase inhibitor treatment.
Liver Cirrhosis, Biliary
Secondary biliary cirrhosis in the rat is prevented by decreasing NF-?B nuclear translocation and TGF-? expression using allopurinol, an inhibitor of xanthine oxidase.
Liver Diseases
Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study.
Liver Diseases
Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats.
Liver Diseases
An ethanol-extract of Ampelopsis brevipedunculata (Vitaceae) berries decreases ferrous iron-stimulated hepatocyte injury in culture.
Liver Diseases
Determination of xanthine oxidase in human serum by a competitive enzyme-linked immunosorbent assay (ELISA).
Liver Diseases
Involvement of xanthine oxidase and paraoxonase 1 in the process of oxidative stress in nonalcoholic fatty liver disease.
Liver Diseases
Oxidation of circulating proteins in alcoholics: role of acetaldehyde and xanthine oxidase.
Liver Diseases
Sodium acetate protects against nicotine-induced excess hepatic lipid in male rats by suppressing xanthine oxidase activity.
Liver Diseases
Xanthine oxidase in nonalcoholic fatty liver disease and hyperuricemia: One stone hits two birds.
Liver Diseases
Xanthine oxidoreductase is present in bile ducts of normal and cirrhotic liver.
Lung Diseases
Detection of xanthine oxidase activity products by EPR and HPLC in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease.
Lung Diseases, Interstitial
Effects of inducible nitric oxide synthase and xanthine oxidase inhibitors on SEB-induced interstitial pneumonia in mice.
Lung Diseases, Interstitial
Inducible nitric oxide synthase, but not xanthine oxidase, is highly expressed in interstitial pneumonias and granulomatous diseases of human lung.
Lung Injury
Assisted mechanical ventilation using elastic unloading: a study in cats with normal and injured lungs.
Lung Injury
Decrease of ischaemia-reperfusion related lung oedema by continuous ventilation and allopurinol in rat perfusion lung model.
Lung Injury
Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury.
Lung Injury
Enhanced levels of lipid peroxidation and xanthine oxidase activity in the lung of male Sprague-Dawley rats following treatment with O,O,S-trimethyl phosphorothioate.
Lung Injury
Febuxostat, an inhibitor of xanthine oxidase, ameliorates ionizing radiation-induced lung injury by suppressing caspase-3, oxidative stress and NF-?B.
Lung Injury
FNLP injures endotoxin-primed rat lung by neutrophil-dependent and -independent mechanisms.
Lung Injury
Gastric intramucosal pH and multiple organ injury: impact of ischemia-reperfusion and xanthine oxidase.
Lung Injury
Hypercapnic acidosis may attenuate acute lung injury by inhibition of endogenous xanthine oxidase.
Lung Injury
In Vivo evidence of free radical generation in the mouse lung after exposure to Pseudomonas Aeruginosa bacterium: An ESR spin-trapping investigation.
Lung Injury
Lung injury and complement activation: role of neutrophils and xanthine oxidase.
Lung Injury
Nitroglycerin does not alter pulmonary vascular permeability in isolated rabbit lungs.
Lung Injury
Oxidative stress in early stage of acute lung injury induced with oleic acid in guinea pigs.
Lung Injury
Respiratory failure caused by intratracheal saline: additive effect of xanthine oxidase.
Lung Injury
Role of xanthine oxidase and neutrophils in ischemia-reperfusion injury in rabbit lung.
Lung Injury
Simultaneous liver and lung injury following gut ischemia is mediated by xanthine oxidase.
Lung Injury
Synergistic production of lung free radicals by diesel exhaust particles and endotoxin.
Lung Injury
Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia. Role in acute lung injury.
Lung Injury
Xanthine oxidase-induced lung injury inhibits removal of 5-hydroxytryptamine from the pulmonary circulation.
Lung Neoplasms
Effect of TEI-6720, a xanthine oxidase inhibitor, on the nucleoside transport in the lung cancer cell line A549.
Lung Neoplasms
Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer.
Lung Neoplasms
[Astragalus polysaccharide inhibits autophagy and regulates expression of autophagy-related proteins in lung cancer A549 cells induced by xanthine oxidase].
Lymphoma
PREVENTION OF HYPERURICEMIA IN LEUKEMIA AND LYMPHOMA: USE OF ALOPURINOL, A XANTHINE OXIDASE INHIBITOR.
Lymphoma
Xanthine oxidase inhibition in the management of hyperuricemia in leukemias and lymphomas.
Malaria
Hypoxanthine depletion induced by xanthine oxidase inhibits malaria parasite growth in vitro.
Malaria
Levels and interactions of plasma xanthine oxidase, catalase and liver function parameters in Nigerian children with Plasmodium falciparum infection.
Malaria
Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide.
Malaria
The antioxidants as protectors of host stress organ injury in mice infected with Plasmodium berghei.
Malnutrition
NADPH oxidase and enhanced superoxide generation in intrauterine undernourished rats: involvement of the renin-angiotensin system.
Malnutrition
[Behavior of xanthine oxidase in inanition and in caloric and rice-diet malnutrition.]
Melanoma
Propolin C from propolis induces apoptosis through activating caspases, Bid and cytochrome c release in human melanoma cells.
Melanoma, Experimental
The superoxide anion may mediate short- but not long-term effects of ultraviolet radiation on melanogenesis.
Meningitis
[Clinical value of the sequential study of the uric acid level in the CSF in patients with postoperative meningitis]
Meningitis, Bacterial
Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis.
Meningitis, Pneumococcal
Mannitol, but not allopurinol, modulates changes in cerebral blood flow, intracranial pressure, and brain water content during pneumococcal meningitis in the rat.
Mesenteric Ischemia
Allopurinol prevents intestinal permeability changes after ischemia-reperfusion injury.
Metabolic Diseases
Antioxidant Activity, Enzyme Inhibition Potentials, and Phytochemical Profiling of Premna serratifolia L. Leaf Extracts.
Metabolic Syndrome
Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study.
Metabolic Syndrome
Alkalizer administration improves renal function in hyperuricemia associated with obesity.
Metabolic Syndrome
Dapagliflozin and xanthine oxidase inhibitors improve insulin resistance and modulate renal glucose and urate transport in metabolic syndrome.
Metabolic Syndrome
Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome.
Metabolic Syndrome
Extract from Eugenia punicifolia is an Antioxidant and Inhibits Enzymes Related to Metabolic Syndrome.
Metabolic Syndrome
In silico design and synthesis of targeted rutin derivatives as xanthine oxidase inhibitors.
Metabolic Syndrome
Mechanistic approach towards interaction of newly synthesized Hesperidin derivatives against xanthine oxidase.
Metabolic Syndrome
Mediterranean diets supplemented with virgin olive oil and nuts enhance plasmatic antioxidant capabilities and decrease xanthine oxidase activity in people with metabolic syndrome: The PREDIMED study.
Metabolic Syndrome
Plumbagin can potently enhance the activity of xanthine oxidase: in vitro, in vivo and in silico studies.
Metabolic Syndrome
Xanthine oxidase activity is associated with risk factors for cardiovascular disease and inflammatory and oxidative status markers in metabolic syndrome: effects of a single exercise session.
Mitochondrial Encephalomyopathies
Treatment of mitochondrial encephalomyopathies with a xanthine oxidase inhibitor.
Mitral Valve Insufficiency
Xanthine Oxidase Inhibition Preserves Left Ventricular Systolic but not Diastolic Function in Cardiac Volume Overload.
Multiple Myeloma
Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma.
Multiple Sclerosis
Cetirizine and allopurinol as novel weapons against cellular autoimmune disorders.
Multiple Sclerosis
Invited review: Bovine milk fat globule membrane as a potential nutraceutical.
Multiple Sclerosis
Xanthine oxidase mediates axonal and myelin loss in a murine model of multiple sclerosis.
Muscular Atrophy
Inhibition of xanthine oxidase by allopurinol prevents skeletal muscle atrophy: role of p38 MAPKinase and E3 ubiquitin ligases.
Muscular Atrophy
Redox regulation of E3 ubiquitin ligases and their role in skeletal muscle atrophy.
Muscular Diseases
Lipid peroxidation and changes in cytochrome c oxidase and xanthine oxidase activity in organophosphorus anticholinesterase induced myopathy.
Muscular Dystrophy, Duchenne
Xanthine oxidase is hyper-active in Duchenne muscular dystrophy.
Myalgia
Inhibition of xanthine oxidase to prevent statin-induced myalgia and rhabdomiolysis.
Myalgia
Responses of criterion variables to different supplemental doses of L-carnitine L-tartrate.
Mycosis Fungoides
Catalase, carbonic anhydrase and xanthine oxidase activities in patients with mycosis fungoides.
Myocardial Infarction
A meta-analysis of the efficacy of allopurinol in reducing the incidence of myocardial infarction following coronary artery bypass grafting.
Myocardial Infarction
A useful canine model of ischemic myocardium with coronary retrograde flow diversion, and its application for the study of allopurinol on myocardial infarct size.
Myocardial Infarction
Antibodies to xanthine oxidase: elevated levels in patients with acute myocardial infarction.
Myocardial Infarction
Chronic administration of allopurinol fails to exert any cardioprotective effect in rats submitted to permanent coronary artery ligation.
Myocardial Infarction
Chronic xanthine oxidase inhibition following myocardial infarction in rabbits: effects of early versus delayed treatment.
Myocardial Infarction
Differential effects of NADPH oxidase and xanthine oxidase inhibition on sympathetic reinnervation in postinfarct rat hearts.
Myocardial Infarction
Effect of allopurinol on cardiomyocyte apoptosis in rats after myocardial infarction.
Myocardial Infarction
Effect of azapropazone and allopurinol on myocardial infarct size in rats.
Myocardial Infarction
Effect of smoking on serum xanthine oxidase and malondialdehyde levels in patients with acute myocardial infarction.
Myocardial Infarction
Effect of vitamin E on the platelet xanthine oxidase and lipid peroxidation in the patients of myocardial infarction.
Myocardial Infarction
Evaluation of the roles of adenosine deaminase and xanthine oxidase in reperfusion injury in patients with myocardial infarction.
Myocardial Infarction
Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs.
Myocardial Infarction
Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance.
Myocardial Infarction
Mechanism-based pharmacokinetic-pharmacodynamic modeling of salvianolic acid A effects on plasma xanthine oxidase activity and uric acid levels in acute myocardial infarction rats.
Myocardial Infarction
Non-invasive limb ischemic pre-conditioning reduces oxidative stress and attenuates myocardium ischemia-reperfusion injury in diabetic rats.
Myocardial Infarction
Noninvasive delayed limb ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in rats by a mitochondrial K(ATP) channel-dependent mechanism.
Myocardial Infarction
Oral administration of L-arginine in patients with angina or following myocardial infarction may be protective by increasing plasma superoxide dismutase and total thiols with reduction in serum cholesterol and xanthine oxidase.
Myocardial Infarction
Oster rediscovered--mega-dose folate for symptomatic atherosclerosis.
Myocardial Infarction
The activity of xanthine oxidase in heart of pigs, guinea pigs, rabbits, rats, and humans.
Myocardial Infarction
Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice.
Myocardial Infarction
Xanthine oxidase inhibitors the unappreciated treatment for heart failure.
Myocardial Infarction
[Adenine nucleotide metabolism in acute myocardial infarct and the initiation of free-radical oxidation]
Myocardial Infarction
[Liraglutide attenuates myocardial ischemia/reperfusion injury possibly through reducing cardiomyocytes apoptosis and oxidation in rats].
Myocardial Infarction
[Xanthine oxidase in homogenized cow's milk and Oster's hypothesis: a review]
Myocardial Ischemia
Age-dependent increase in xanthine oxidoreductase differs in various heart cell types.
Myocardial Ischemia
Arrhythmias and infarction in the ischemic pig heart are not mediated by xanthine oxidase-derived free oxygen radicals.
Myocardial Ischemia
Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs.
Myocardial Ischemia
Inhibition of xanthine oxidase improves myocardial contractility in patients with ischemic cardiomyopathy.
Myocardial Ischemia
Ischemic heart diseases in Egypt: role of xanthine oxidase system and ischemia-modified albumin.
Myocardial Ischemia
Nrf2 for cardiac protection: pharmacological options against oxidative stress.
Myocardial Ischemia
Role of NADPH oxidase and xanthine oxidase in mediating inducible VT/VF and triggered activity in a canine model of myocardial ischemia.
Myocardial Ischemia
The role of xanthine oxidase during myocardial ischemia in several species including man.
Myocardial Ischemia
The xanthine oxidase inhibitor oxypurinol does not limit infarct size in a canine model of 40 minutes of ischemia with reperfusion.
Myocardial Ischemia
Xanthine oxidase as a source of free radical damage in myocardial ischemia.
Myocardial Ischemia
[Indicator Characterizing Carbonyl-Dependent Modification of Erythrocytic Superoxydismutase as a Biochemical Marker of Oxidative Stress in Coronary Heart Disease].
Myocardial Reperfusion Injury
Evaluation of the role of xanthine oxidase in myocardial reperfusion injury.
Myocardial Reperfusion Injury
Protection from reperfusion injury in the isolated rat heart by postischaemic deferoxamine and oxypurinol administration.
Myocardial Reperfusion Injury
Reactive Oxygen Species in Myocardial Reperfusion Injury: From Physiopathology to Therapeutic Approaches.
Myocardial Reperfusion Injury
Xanthine oxidase inhibition does not limit canine infarct size.
Myocardial Reperfusion Injury
[Myocardial reperfusion injury. The role of free radicals and xanthine oxidase]
Myocardial Stunning
Effects of verapamil on myocardial stunning in xanthine-oxidase deficient hearts: pre-treatment vs. post-ischemic treatment.
Myocardial Stunning
Evidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium.
Myocardial Stunning
Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs.
Myocardial Stunning
Superoxide dismutase attenuated post-ischaemic contractile dysfunction in a myocardial xanthine oxidase deficient species.
Neoplasm Metastasis
The emerging role of xanthine oxidase inhibition for suppression of breast cancer cell migration and metastasis associated with hypercholesterolemia.
Neoplasms
2-Methoxyestradiol enhances reactive oxygen species formation and increases the efficacy of oxygen radical generating tumor treatment.
Neoplasms
A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain.
Neoplasms
Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo.
Neoplasms
Adenosine deaminase, nucleoside phorphorylase and xanthine oxidase in liver tumours.
Neoplasms
An in-depth view of potential dual effect of thymol in inhibiting xanthine oxidase activity: Electrochemical measurements in combination with four way PARAFAC analysis and molecular docking insights.
Neoplasms
Anticarcinogenic effect of Nymphaea alba against oxidative damage, hyperproliferative response and renal carcinogenesis in Wistar rats.
Neoplasms
Anticolon Cancer Properties of Pyrazole Derivatives Acting through Xanthine Oxidase Inhibition.
Neoplasms
Antioxidative, antimutagenic, and anticarcinogenic activities of rice bran extracts in chemical and cell assays.
Neoplasms
Attenuation of Neutrophil Infiltration and Proinflammatory Cytokines by Cissus QuadrangularisA Possible Prevention Against Gastric Ulcerogenesis.
Neoplasms
Autophagy-Regulated ROS from Xanthine Oxidase Acts as an Early Effector for Triggering Late Mitochondria-Dependent Apoptosis in Cathepsin S-Targeted Tumor Cells.
Neoplasms
Barbiturate derivatives for managing multifaceted oncogenic pathways: A mini review.
Neoplasms
Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation.
Neoplasms
Catalase, carbonic anhydrase and xanthine oxidase activities in patients with mycosis fungoides.
Neoplasms
Chemomodulatory effect of Ficus racemosa extract against chemically induced renal carcinogenesis and oxidative damage response in Wistar rats.
Neoplasms
Chinese Herbs and Repurposing Old Drugs as Therapeutic Agents in the Regulation of Oxidative Stress and Inflammation in Pulmonary Diseases.
Neoplasms
Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway.
Neoplasms
Cisplatin-induced renal toxicity via tumor necrosis factor-?, interleukin 6, tumor suppressor P53, DNA damage, xanthine oxidase, histological changes, oxidative stress and nitric oxide in rats: Protective effect of ginseng.
Neoplasms
Conversion of xanthine dehydrogenase to xanthine oxidase as a possible marker for hypoxia in tumours and normal tissues.
Neoplasms
Cytotoxicity of lipophilic statins depends on their combined actions on HIF-1? expression and redox status in B16.F10 melanoma cells.
Neoplasms
Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1.
Neoplasms
Discovery of Novel Allopurinol Derivatives with Anticancer Activity and Attenuated Xanthine Oxidase Inhibition.
Neoplasms
Discussion on mammary tumors: xanthine oxidase activity in normal & abnormal growth.
Neoplasms
Effect of Holstein genotype on innate immune and metabolic responses of heifers to lipopolysaccharide (LPS) administration.
Neoplasms
Effect of simultaneous inhibition of TNF-alpha production and xanthine oxidase in experimental acute pancreatitis: the role of mitogen activated protein kinases.
Neoplasms
Effects of Aster glehni Extract on Serum Uric Acid in Subjects with Mild Hyperuricemia: A Randomized, Placebo-Controlled Trial.
Neoplasms
Efficacy and safety of febuxostat for prevention of tumor lysis syndrome in patients with malignant tumors receiving chemotherapy: a phase III, randomized, multi-center trial comparing febuxostat and allopurinol.
Neoplasms
Efficacy of a Standardized Turmeric Extract Comprised of 70% Bisdemothoxy-Curcumin (REVERC3) Against LPS-Induced Inflammation in RAW264.7 Cells and Carrageenan-Induced Paw Edema.
Neoplasms
Efficiency of ginger (Zingbar officinale) against Schistosoma mansoni infection during host-parasite association.
Neoplasms
Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles.
Neoplasms
Enhancement of oxidative cell injury and antitumor effects of localized 44 degrees C hyperthermia upon combination with respiratory hyperoxia and xanthine oxidase.
Neoplasms
Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice.
Neoplasms
Evidence that iron-overload promotes 7,12-dimethylbenz(a)anthracene- induced skin tumorigenesis in mice.
Neoplasms
Febuxostat Improves the Local and Remote Organ Changes Induced by Intestinal Ischemia/Reperfusion in Rats.
Neoplasms
Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics.
Neoplasms
Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis.
Neoplasms
HDAC11 deletion reduces fructose-induced cardiac dyslipidemia, apoptosis and inflammation by attenuating oxidative stress injury.
Neoplasms
Human red blood cell membrane oxidase and horseradish peroxidase cleavage of folic acid: evidence for formation of singlet oxygen.
Neoplasms
Hyperthermia enhances the cytotoxic effects of reactive oxygen species to Chinese hamster cells and bovine endothelial cells in vitro.
Neoplasms
Hypouricemic and Nephroprotective Effects of an Active Fraction from Polyrhachis Vicina Roger On Potassium Oxonate-Induced Hyperuricemia in Rats.
Neoplasms
Hypouricemic effect and safety of febuxostat used for prevention of tumor lysis syndrome.
Neoplasms
Imbalance of purine metabolism in hepatomas of different growth rates as expressed in behavior of xanthine oxidase (EC 1.2.3.2).
Neoplasms
In silico design and synthesis of targeted rutin derivatives as xanthine oxidase inhibitors.
Neoplasms
In vitro effects of mangiferin on superoxide concentrations and expression of the inducible nitric oxide synthase, tumour necrosis factor-alpha and transforming growth factor-beta genes.
Neoplasms
Influence of heating on the activity of xanthine oxidase in tumor cells subjected to the phototoxic action of hematoporphyrin derivative.
Neoplasms
Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa.
Neoplasms
Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia.
Neoplasms
Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NIH3T3 cells.
Neoplasms
Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture.
Neoplasms
Jasonia glutinosa (L.) DC., a traditional herbal medicine, reduces inflammation, oxidative stress and protects the intestinal barrier in a murine model of colitis.
Neoplasms
Levels of certain tumor markers as differential factors between bilharzial and non-biharzial bladder cancer among Egyptian patients.
Neoplasms
Lupeol, a triterpene, prevents free radical mediated macromolecular damage and alleviates benzoyl peroxide induced biochemical alterations in murine skin.
Neoplasms
Malignant transformation-linked imbalance: decreased xanthine oxidase activity in hepatomas.
Neoplasms
Mechanisms of endothelial cell killing by H2O2 or products of activated neutrophils.
Neoplasms
Mechanistic approach towards interaction of newly synthesized Hesperidin derivatives against xanthine oxidase.
Neoplasms
Metformin protects against diabetes-induced heart injury and dunning prostate cancer model.
Neoplasms
Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis: Variability in tumor necrosis factor-?, nitric oxide, and xanthine oxidase responses to endotoxin challenge in steers.
Neoplasms
Modulatory effects of Pluchea lanceolata against chemically induced oxidative damage, hyperproliferation and two-stage renal carcinogenesis in Wistar rats.
Neoplasms
Monosodium Urate and Tumor Necrosis Factor-? Increase Apoptosis in Human Chondrocyte Cultures.
Neoplasms
Murine epidermal xanthine oxidase activity: correlation with degree of hyperplasia induced by tumor promoters.
Neoplasms
Oral Submucous Fibrosis as an Overhealing Wound: Implications in Malignant Transformation.
Neoplasms
Oxidoreductase activities in normal rat liver, tumor-bearing rat liver, and hepatoma HC-252.
Neoplasms
Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study.
Neoplasms
Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases.
Neoplasms
Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats: role of oxygen free radicals generation.
Neoplasms
Salix caprea inhibits skin carcinogenesis in murine skin: inhibition of oxidative stress, ornithine decarboxylase activity and DNA synthesis.
Neoplasms
Structure-activity relationship of caffeic acid analogues on xanthine oxidase inhibition.
Neoplasms
Studies in tissue metabolism: Lactic dehydrogenase, xanthine oxidase and nucleosidase in tumour and muscle extracts.
Neoplasms
Sublethal oxidative stress inhibits tumor cell adhesion and enhances experimental metastasis of murine mammary carcinoma.
Neoplasms
Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of Langerhans and insulin secreting cell lines, but dictate cell death by different mechanisms.
Neoplasms
Synergistic antioxidant capacities of vanillin and chitosan nanoparticles against reactive oxygen species, hepatotoxicity, and genotoxicity induced by aging in male Wistar rats.
Neoplasms
Synthesis and antioxidant, cytotoxicity and antimicrobial activities of novel curcumin mimics.
Neoplasms
Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors.
Neoplasms
Synthesis of resveratrol analogues, and evaluation of their cytotoxic and xanthine oxidase inhibitory activities.
Neoplasms
Synthesis, biological evaluation and molecular docking studies of bis-chalcone derivatives as xanthine oxidase inhibitors and anticancer agents.
Neoplasms
The effects of the Pringle maneuver on the pancreas: can octreotide be protective?
Neoplasms
The emerging role of xanthine oxidase inhibition for suppression of breast cancer cell migration and metastasis associated with hypercholesterolemia.
Neoplasms
The Impact of Pre-Cooling and CoQ10 Supplementation on Mediators of Inflammatory Cytokines in Elite Swimmers.
Neoplasms
The inhibition of DMBA-induced carcinogenesis by neoxanthin in hamster buccal pouch.
Neoplasms
The inhibitory effects of allopurinol on the production and cytotoxicity of tumor necrosis factor.
Neoplasms
The pathogenesis of L-arginine-induced acute necrotizing pancreatitis: inflammatory mediators and endogenous cholecystokinin.
Neoplasms
The relation of diet, hormones, and tumors to the activity of liver xanthine oxidase in the rat.
Neoplasms
The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat.
Neoplasms
The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy.
Neoplasms
Tumor necrosis factor-alpha alters response of lung cancer cells to oxidative stress.
Neoplasms
Tumor Promotion and Oxidative Stress in Ferric Nitrilotriacetate-Mediated Renal Carcinogenesis: Protection by Adhatoda vasica.
Neoplasms
Variability in tumor necrosis factor-alpha, nitric oxide, and xanthine oxidase responses to endotoxin challenge in heifers: effect of estrous cycle stage.
Neoplasms
Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties.
Neoplasms
Xanthine oxidase activity in intestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride.
Neoplasms
Xanthine oxidase and tumor necrosis factor alpha: possible mediators of remote tissue injury after viper envenomation.
Neoplasms
Xanthine Oxidase/Dehydrogenase Activity as a Source of Oxidative Stress in Prostate Cancer Tissue.
Neoplasms
[Clinical value of the sequential study of the uric acid in CSF in patients with cerebral diseases: Part I. Brain tumor and the effect of irradiation]
Neoplasms
[Determination of xanthine oxidase in tissue cultures, in tissue slices and in tumor cell suspensions]
Neoplasms
[Dynamics of the cytokines, homocysteine contents, indices of oxydative and nitrosative stress and cytopathic hypoxia in patients after cholecystectomy for acute cholecystitis. Connection with rate of postoperative purulent-inflammatory complications]
Neoplasms
[Effect of danhong injection on cerebral injury in patients undergoing coronary artery bypass graft operation with extracorporeal circulation]
Neoplasms
[Paeoniflorin Improves Acute Lung Injury in Sepsis by Activating Nrf2/Keap1 Signaling Pathway].
Neoplasms
[Protective effects of tongli gongxia herbs on gut barrier in rat with multiple organ dysfunction syndrome]
Nephrolithiasis
Beware the low urine pH-the major cause of the increased prevalence of nephrolithiasis in the patient with type 2 diabetes.
Nephrolithiasis
Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection.
Nephrosis
Effect of dietary protein restriction on renal purines and purine-metabolizing enzymes in adriamycin nephrosis in rats: a mechanism for protection against acute proteinuria involving xanthine oxidase inhibition.
Nephrosis
Modulation of proteinuria and renal xanthine oxidase activity by dietary proteins in acute adriamycin nephrosis in rats: lack of correlation with intra- and extracellular amino acids.
Nephrosis
Podocyte architecture in puromycin aminonucleoside-treated rats administered tungsten or allopurinol.
Nephrosis
Renal purine efflux and xanthine oxidase activity during experimental nephrosis in rats: difference between puromycin aminonucleoside and adriamycin nephrosis.
Nervous System Diseases
Testosterone induces neuroprotection from oxidative stress. Effects on catalase activity and 3-nitro-L-tyrosine incorporation into alpha-tubulin in a mouse neuroblastoma cell line.
Neuralgia
Assessment of anti-nociceptive effect of allopurinol in a neuropathic pain model.
Neuroblastoma
A comparison of purine metabolism and nucleotide pools in normal and hypoxanthine-guanine phosphoribosyltransferase-deficient neuroblastoma cells.
Neuroblastoma
Effects of C-reactive protein and pentosan polysulphate on human complement activation.
Neurodegenerative Diseases
Xanthine oxidase-induced neuronal death via the oxidation of NADH: prevention by micromolar EDTA.
Neutropenia
Neutrophil mediated microvascular injury in acute, experimental compartment syndrome.
Neutropenia
Should 6-thioguanine nucleotides be monitored in heart transplant recipients given azathioprine?
Non-alcoholic Fatty Liver Disease
Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats.
Non-alcoholic Fatty Liver Disease
Gender effect of hyperuricemia on the development of nonalcoholic fatty liver disease (NAFLD): A clinical analysis and mechanistic study.
Non-alcoholic Fatty Liver Disease
Involvement of xanthine oxidase and paraoxonase 1 in the process of oxidative stress in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction.
Non-alcoholic Fatty Liver Disease
Sodium acetate protects against nicotine-induced excess hepatic lipid in male rats by suppressing xanthine oxidase activity.
Non-alcoholic Fatty Liver Disease
The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.
Non-alcoholic Fatty Liver Disease
Xanthine oxidase in nonalcoholic fatty liver disease and hyperuricemia: One stone hits two birds.
Obesity
Alkalizer administration improves renal function in hyperuricemia associated with obesity.
Obesity
Body mass index is independently associated with xanthine oxidase activity in overweight/obese population.
Obesity
The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol.
Obesity
Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity.
Obesity, Morbid
Sleeve gastrectomy reduces xanthine oxidase and uric acid in a rat model of morbid obesity.
Obesity, Morbid
Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity.
Oligospermia
The significance of testicular reactive oxygen species on testicular histology in infertile patients.
ornithine carbamoyltransferase deficiency
Two-dimensional thin-layer chromatography for the screening of disorders of purine and pyrimidine metabolism.
Ornithine Carbamoyltransferase Deficiency Disease
Two-dimensional thin-layer chromatography for the screening of disorders of purine and pyrimidine metabolism.
Osteoarthritis
[Purine metabolism enzymes in diagnosis and differential diagnosis of osteoarthritis and gout arthritis]
Osteoarthritis, Knee
In vivo effect of celecoxib and tenoxicam on oxidant/ anti-oxidant status of patients with knee osteoarthritis.
Otitis Media
Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion.
Otitis Media with Effusion
Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion.
Pancreatitis
"Cocktail" therapy for acute pancreatitis: combined therapy of protease inhibitor, xanthine oxidase inhibitor and platelet activating factor antagonist in rat caerulein-induced pancreatis.
Pancreatitis
A prospective, randomized, placebo-controlled trial of prednisone and allopurinol in the prevention of ERCP-induced pancreatitis.
Pancreatitis
Changes of xanthine oxidase, lipid peroxide and superoxide dismutase in mouse acute pancreatitis.
Pancreatitis
Effect of prostaglandins and superoxide dismutase administration on oxygen free radical production in experimental acute pancreatitis.
Pancreatitis
Effect of simultaneous inhibition of TNF-alpha production and xanthine oxidase in experimental acute pancreatitis: the role of mitogen activated protein kinases.
Pancreatitis
Free radicals generated by xanthine oxidase mediate pancreatitis-associated organ failure.
Pancreatitis
Generation of free oxygen radicals in the pathogenesis of experimental acute reflux pancreatitis.
Pancreatitis
Heparin mobilizes xanthine oxidase and induces lung inflammation in acute pancreatitis.
Pancreatitis
High-dose allopurinol for prevention of post-ERCP pancreatitis: a prospective randomized double-blind controlled trial.
Pancreatitis
Involvement of oxygen-derived free radicals in L-arginine-induced acute pancreatitis.
Pancreatitis
Mobilization of xanthine oxidase from the gastrointestinal tract in acute pancreatitis.
Pancreatitis
Oxidative stress in distant organs and the effects of allopurinol during experimental acute pancreatitis.
Pancreatitis
Pancreatitis induces HSP72 in the lung: role of neutrophils and xanthine oxidase.
Pancreatitis
Preservation-induced pancreatitis in an isolated perfused pancreas model in the dog.
Pancreatitis
Pretreatment with allopurinol diminishes pancreatography-induced pancreatitis in a canine model.
Pancreatitis
Protective effects of combined therapy with a protease inhibitor, ONO 3307, and a xanthine oxidase inhibitor, allopurinol on temporary ischaemic model of pancreatitis in rats.
Pancreatitis
Protective effects of therapy with a protease and xanthine oxidase inhibitor in short form pancreatic biliary obstruction and ischemia in rats.
Pancreatitis
Role of P-selectin and ICAM-1 in pancreatitis-induced lung inflammation in rats: significance of oxidative stress.
Pancreatitis
Temporal efficacy of allopurinol during the induction of pancreatitis in the ex vivo perfused canine pancreas.
Pancreatitis
The involvement and sources of active oxygen in experimentally induced acute pancreatitis.
Pancreatitis
The mechanism of conversion of xanthine dehydrogenase to xanthine oxidase in acute pancreatitis in the canine isolated pancreas preparation.
Pancreatitis
The pathogenesis of acute pancreatitis. The source and role of oxygen-derived free radicals in three different experimental models.
Pancreatitis
The role of polymorphonuclear leukocytes and oxygen-derived free radicals in experimental acute pancreatitis: mediators of local destruction and activators of inflammation.
Pancreatitis
Xanthine oxidase activation in cerulein- and taurocholate-induced acute pancreatitis in rats.
Pancreatitis
Xanthine oxidase activity in mouse pancreas: effects of caerulein-induced acute pancreatitis.
Pancreatitis
Xanthine oxidase inhibitor in acute experimental pancreatitis in rats and mice.
Pancreatitis
[Effects of several regulatory peptides on the functional activity of the pancreas in acute experimental pancreatitis]
Pancreatitis
[Role of free radicals on canine bile-induced pancreatitis and effect of superoxide dismutase]
Pancreatitis, Alcoholic
Detailed characterization of experimental acute alcoholic pancreatitis.
Parasitemia
Antagonist effect of chloroquine and tumor necrosis factor on hepatic oxidative stress and antioxidant defense in normal and Plasmodium yoelii nigeriensis-infected mice.
Parasitemia
Serum xanthine oxidase: origin, regulation, and contribution to control of trypanosome parasitemia.
Parasitemia
Studies on hepatic oxidative stress and antioxidant defence systems during arteether treatment of Plasmodium yoelii nigeriensis infected mice.
Parasitemia
Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide.
Parasitemia
[Influence of xanthine oxidase on duration of asexual cycle of Plasmodium vinckei in the mouse (author's transl)]
Parkinson Disease
Serum glutathione peroxidase, xanthine oxidase, and superoxide dismutase activities and malondialdehyde levels in patients with Parkinson's disease.
Peptic Ulcer
[A family of hereditary xanthinuria: two siblings with peptic ulcer and hypouricemia due to xanthine oxidase deficiency, and a heterozygote (father) with gout]
Peripheral Nervous System Diseases
Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice.
Peripheral Nervous System Diseases
Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy.
Photosensitivity Disorders
A novel mechanism for the generation of superoxide anions in hematoporphyrin derivative-mediated cutaneous photosensitization. Activation of the xanthine oxidase pathway.
Photosensitivity Disorders
Influence of heating on the activity of xanthine oxidase in tumor cells subjected to the phototoxic action of hematoporphyrin derivative.
Pneumonia
Effect of simultaneous inhibition of TNF-alpha production and xanthine oxidase in experimental acute pancreatitis: the role of mitogen activated protein kinases.
Pneumonia
Further studies of interrelationship between xanthine oxidase and influenzal pneumonia in mice.
Pneumonia
Heparin mobilizes xanthine oxidase and induces lung inflammation in acute pancreatitis.
Pneumonia
Role of cytokines and oxidative stress in the pathophysiology of acute pancreatitis: therapeutical implications.
Pneumonia
Synergistic production of lung free radicals by diesel exhaust particles and endotoxin.
Polycystic Ovary Syndrome
Assessment of paraoxonase 1, xanthine oxidase and glutathione peroxidase activities, nitric oxide and thiol levels in women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?
Pre-Eclampsia
Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia.
Pre-Eclampsia
Maternal and fetal plasma adenosine deaminase, xanthine oxidase and malondialdehyde levels in pre-eclampsia.
Pre-Eclampsia
Perfusion of the human placenta with red blood cells and xanthine oxidase mimics preeclampsia in-vitro.
Pre-Eclampsia
Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre-eclampsia.
Pre-Eclampsia
Relationship Between Xanthine Oxidase, Ischemia Modified Albumin, Nitric Oxide with Antioxidants in Non Pregnants, Pre and Post-delivery of Normal Pregnants and Preeclampsia.
Pre-Eclampsia
Study of serum uric acid and creatinine in hypertensive disorders of pregnancy.
Pre-Eclampsia
The relationship between hypertension and plasma allantoin, uric acid, xanthine oxidase activity and nitrite, and their predictive capacity in severe preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute lymphocytic leukemia in a child with congenital xanthine oxidase deficiency: implications for therapy.
Prostatic Hyperplasia
Febuxostat attenuates testosterone-induced benign prostatic hyperplasia in rats via inhibiting JAK/STAT axis.
Prostatic Neoplasms
Anti-oxidative and anti-proliferative activity on human prostate cancer cells lines of the phenolic compounds from Corylopsis coreana Uyeki.
Prostatic Neoplasms
Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation.
Protein Deficiency
The effect of protein deficiency on the liver of albino rats. I. The influence of different levels of dietary protein on total nitrogen, succinic dehydrogenase and xanthine oxidase in liver.
Proteinuria
Effect of dietary protein restriction on renal purines and purine-metabolizing enzymes in adriamycin nephrosis in rats: a mechanism for protection against acute proteinuria involving xanthine oxidase inhibition.
Proteinuria
Modulation of proteinuria and renal xanthine oxidase activity by dietary proteins in acute adriamycin nephrosis in rats: lack of correlation with intra- and extracellular amino acids.
Proteinuria
Potential sources of oxidative stress that induce postexercise proteinuria in rats.
Proteinuria
Renal purine efflux and xanthine oxidase activity during experimental nephrosis in rats: difference between puromycin aminonucleoside and adriamycin nephrosis.
Pseudomonas Infections
Changes in hepatic superoxide dismutase and xanthine oxidase activity in mice infected with Salmonella typhimurium and Pseudomonas aeruginosa.
Pulmonary Disease, Chronic Obstructive
Cytokine-mediated xanthine oxidase upregulation in chronic obstructive pulmonary disease's airways.
Pulmonary Disease, Chronic Obstructive
Detection of xanthine oxidase activity products by EPR and HPLC in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Implication of xanthine oxidase in muscle oxidative stress in COPD patients.
Pulmonary Disease, Chronic Obstructive
Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Xanthine oxidase activity in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways.
Pulmonary Disease, Chronic Obstructive
Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease.
Pulmonary Edema
Pulmonary reexpansion causes xanthine oxidase-induced apoptosis in rat lung.
Pulmonary Edema
Role of xanthine oxidase and reactive oxygen intermediates in LPS- and TNF-induced pulmonary edema.
Pulmonary Edema
Vasoactive intestinal peptide prevents lung injury due to xanthine/xanthine oxidase.
purine-nucleoside phosphorylase deficiency
Two-dimensional thin-layer chromatography for the screening of disorders of purine and pyrimidine metabolism.
Renal Artery Obstruction
Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study.
Renal Insufficiency
Crystalline Nephropathy due to APRT Deficiency: A Preventable Cause of Renal and Renal Allograft Failure.
Renal Insufficiency
Management of acute and chronic gouty arthritis: present state-of-the-art.
Renal Insufficiency
The role of oxygen free radicals in acute renal failure complicating obstructive jaundice: an experimental study.
Renal Insufficiency, Chronic
A single-centre experience of febuxostat as a second-line urate-lowering therapy.
Renal Insufficiency, Chronic
Association Between Kidney Function Decline and Baseline TNFR Levels or Change Ratio in TNFR by Febuxostat Chiefly in Non-diabetic CKD Patients With Asymptomatic Hyperuricemia.
Renal Insufficiency, Chronic
Cardio-renal protective effect of the xanthine oxidase inhibitor febuxostat in the 5/6 nephrectomy model with hyperuricemia.
Renal Insufficiency, Chronic
Comparison of long-term efficacy and renal safety of febuxostat and allopurinol in patients with chronic kidney diseases?.
Renal Insufficiency, Chronic
Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia.
Renal Insufficiency, Chronic
Efficacy and Safety of Febuxostat in Kidney Transplant Patients.
Renal Insufficiency, Chronic
Efficacy of xanthine oxidase inhibitor for chronic kidney disease patients with hyperuricemia.
Renal Insufficiency, Chronic
Febuxostat for treating allopurinol-resistant hyperuricemia in patients with chronic kidney disease.
Renal Insufficiency, Chronic
Febuxostat hypersensitivity: another cause of DRESS syndrome in chronic kidney disease?
Renal Insufficiency, Chronic
Major Cardiovascular Events in Patients with Gout and Associated Cardiovascular Disease or Heart Failure and Chronic Kidney Disease Initiating a Xanthine Oxidase Inhibitor.
Renal Insufficiency, Chronic
Plasma Xanthine Oxidase Activity Is Predictive of Cardiovascular Disease in Patients with Chronic Kidney Disease, Independently of Uric Acid Levels.
Renal Insufficiency, Chronic
Relationship between Xanthine Oxidoreductase Redox and Oxidative Stress among Chronic Kidney Disease Patients.
Renal Insufficiency, Chronic
The Crucial Role of Xanthine Oxidase in CKD Progression Associated with Hypercholesterolemia.
Renal Insufficiency, Chronic
The role of uric acid in kidney fibrosis: experimental evidences for the causal relationship.
Renal Insufficiency, Chronic
The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model.
Renal Insufficiency, Chronic
Uric acid as a cardiorenal risk factor - ready for prime-time?
Renal Insufficiency, Chronic
Xanthine Oxidase Inhibitors for Improving Renal Function in Chronic Kidney Disease Patients: An Updated Systematic Review and Meta-Analysis.
Renal Insufficiency, Chronic
Xanthine oxidase inhibitors may prevent or slow chronic kidney disease even in the absence of hyperuricemia.
Renal Insufficiency, Chronic
[Effect of concomitant chronic kidney disease on the xanthine metabolism in patients with chronic heart failure].
Reperfusion Injury
2,6-Dichlorophenolindophenol is a competitive inhibitor for xanthine oxidase and is therefore not usable as an electron acceptor in the fluorometric assay.
Reperfusion Injury
A tungsten-supplemented diet delivered by transplacental and breast-feeding routes lowers intestinal xanthine oxidase activity and affords cytoprotection in ischemia-reperfusion injury to the small intestine.
Reperfusion Injury
Allopurinol improves cardiac dysfunction after ischemia-reperfusion via reduction of oxidative stress in isolated perfused rat hearts.
Reperfusion Injury
Allopurinol improves myocardial reperfusion injury in a xanthine oxidase-free model.
Reperfusion Injury
Allopurinol modulates reactive oxygen species generation and Ca2+ overload in ischemia-reperfused heart and hypoxia-reoxygenated cardiomyocytes.
Reperfusion Injury
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
Reperfusion Injury
Allopurinol plus standard resuscitation preserves hepatic blood flow and function following hemorrhagic shock.
Reperfusion Injury
Allopurinol protects the bowel from necrosis caused by indomethacin and temporary intestinal ischemia in mice.
Reperfusion Injury
Amelioration of ischemia-reperfusion injury in rat intestine by pentoxifylline-mediated inhibition of xanthine oxidase.
Reperfusion Injury
An evaluation of antioxidant effects on recovery from postischemic acute renal failure.
Reperfusion Injury
An evaluation of the effects of perioperatively administered fluids on ischemia/reperfusion injury.
Reperfusion Injury
BI1 alleviates cardiac microvascular ischemia-reperfusion injury via modifying mitochondrial fission and inhibiting XO/ROS/F-actin pathways.
Reperfusion Injury
Circulating xanthine oxidase and neutrophil activation during human liver transplantation.
Reperfusion Injury
Comparative effects of methylprednisolone and tetracosactide (ACTH1-24) on ischemia/reperfusion injury of the rabbit spinal cord.
Reperfusion Injury
Correlation of red cell antioxidant status and heart-lung function in swine pretreated with allopurinol (a model of heart-lung transplantation).
Reperfusion Injury
Distribution of xanthine oxidoreductase activity in human tissues--a histochemical and biochemical study.
Reperfusion Injury
Effect of allopurinol on venous endothelial dysfunction after resuscitated hemorrhagic shock.
Reperfusion Injury
Effect of ischemia reperfusion or hypoxia reoxygenation on lung vascular permeability and resistance.
Reperfusion Injury
Evaluation of the roles of adenosine deaminase and xanthine oxidase in reperfusion injury in patients with myocardial infarction.
Reperfusion Injury
Evidence that the large loss of glutathione observed in ischemia/reperfusion of the small intestine is not due to oxidation to glutathione disulfide.
Reperfusion Injury
Existence and participation of xanthine oxidase in reperfusion injury of ischemic rabbit myocardium.
Reperfusion Injury
Flavonoids and Anthranquinones as Xanthine Oxidase and Monoamine Oxidase Inhibitors: A New Approach Towards Inflammation and Oxidative Stress.
Reperfusion Injury
Immunoaffinity localization of the enzyme xanthine oxidase on the outside surface of the endothelial cell plasma membrane.
Reperfusion Injury
Implication of superoxide radicals on ischemia-reperfusion-induced skeletal muscle injury in rats.
Reperfusion Injury
Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat.
Reperfusion Injury
Is reperfusion injury an important cause of mucosal damage after porcine intestinal ischemia?
Reperfusion Injury
Ischemia and reperfusion injury in isolated rat heart: effect of reperfusion duration on xanthine oxidase, lipid peroxidation, and enzyme antioxidant systems in myocardium.
Reperfusion Injury
Lung preconditioning with N-acetyl-L-cysteine prevents reperfusion injury after liver no flow-reflow: a dose-response study.
Reperfusion Injury
Mechanisms of cellular injury: potential sources of oxygen free radicals in ischemia/reperfusion.
Reperfusion Injury
Minimal role of xanthine oxidase and oxygen free radicals in rat renal tubular reoxygenation injury.
Reperfusion Injury
Morphologic changes and xanthine oxidase activity in the equine jejunum during low flow ischemia and reperfusion.
Reperfusion Injury
Neuroprotective effect of penehyclidine hydrochloride on focal cerebral ischemia-reperfusion injury.
Reperfusion Injury
No conversion of xanthine dehydrogenase to oxidase in canine cerebral ischemia.
Reperfusion Injury
Oxygen radical-mediated vascular injury selectively inhibits receptor-dependent release of nitric oxide from canine coronary arteries.
Reperfusion Injury
Oxygen-derived free radicals in hepatic ischemia and reperfusion injury in the rat.
Reperfusion Injury
Potential role of mitochondrial calcium metabolism during reperfusion injury.
Reperfusion Injury
Protein carbonyl formation and tyrosine nitration as markers of oxidative damage during ischaemia-reperfusion injury to rat sciatic nerve.
Reperfusion Injury
Pulmonary oxygen toxicity and ischemia-reperfusion injury. A mechanism in common involving xanthine oxidase and neutrophils.
Reperfusion Injury
Purification and immunohistochemical tissue localization of human xanthine oxidase.
Reperfusion Injury
Purine metabolic pathways in rat hindlimb perfusion model during ischemia and reperfusion.
Reperfusion Injury
Rapid conversion to high xanthine oxidase activity in viable Kupffer cells during hypoxia.
Reperfusion Injury
Reperfusion injury and reactive oxygen species: The evolution of a concept.
Reperfusion Injury
Reperfusion mucosal damage after complete intestinal ischemia in the dog: the effects of antioxidant and phospholipase A2 inhibitor therapy.
Reperfusion Injury
Response to allopurinol pretreatment in a swine model of heart-lung transplantation.
Reperfusion Injury
Role of purines and xanthine oxidase in reperfusion injury in perfused rat liver.
Reperfusion Injury
Role of xanthine oxidase and eicosanoids in development of pancreatic ischemia-reperfusion injury.
Reperfusion Injury
Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury.
Reperfusion Injury
Role of xanthine oxidase and neutrophils in ischemia-reperfusion injury in rabbit lung.
Reperfusion Injury
Role of xanthine oxidase in reperfusion injury of ischemic skeletal muscles in the pig and human.
Reperfusion Injury
Role of xanthine oxidase inhibitor as free radical scavenger: a novel mechanism of action of allopurinol and oxypurinol in myocardial salvage.
Reperfusion Injury
Significance of xanthine oxidase in the production of intracellular oxygen radicals in an in-vitro hypoxia-reoxygenation model.
Reperfusion Injury
Stress ulceration and gastric mucosal cell kinetics: the influence of prophylaxis against acute stress ulceration.
Reperfusion Injury
Studies on the oxygen radical mechanism involved in the small intestinal reperfusion damage.
Reperfusion Injury
Synthesis and characterization of CAPE derivatives as xanthine oxidase inhibitors with radical scavenging properties.
Reperfusion Injury
The conversion of xanthine dehydrogenase to xanthine oxidase and the role of the enzyme in reperfusion injury.
Reperfusion Injury
The effects of allopurinol on the ultrastructure of ischaemic and reperfused large intestine of sheep.
Reperfusion Injury
The effects of verapamil vs. allopurinol on intestinal ischemia/reperfusion injury in rats. "An experimental study".
Reperfusion Injury
The physiology of endothelial xanthine oxidase: from urate catabolism to reperfusion injury to inflammatory signal transduction.
Reperfusion Injury
The prognostic impact of allopurinol in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.
Reperfusion Injury
The protective effect of low-dose methotrexate on ischemia-reperfusion injury of the rabbit spinal cord.
Reperfusion Injury
The relationship between the adenine nucleotide metabolism and the conversion of the xanthine oxidase enzyme system in ischemia-reperfusion of the rat small intestine.
Reperfusion Injury
The role of reperfusion injury in photodynamic therapy with 5-aminolaevulinic acid--a study on normal rat colon.
Reperfusion Injury
Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate of (styrene-maleic acid copolymer) and (4-amino-6-hydroxypyrazolo[3,4-d]pyrimidine), on hepatic ischemia-reperfusion injury.
Reperfusion Injury
Trolox is more successful than allopurinol to reduce degenerative effects of testicular ischemia/reperfusion injury in rats.
Reperfusion Injury
Xanthine oxidase and superoxide radicals in portal triad crossclamping-induced microvascular reperfusion injury of the liver.
Reperfusion Injury
Xanthine oxidase formation during experimental ischemia of the equine small intestine.
Reperfusion Injury
Xanthine oxidase inhibition attenuates kupffer cell production of neutrophil chemoattractant following ischemia-reperfusion in rat liver.
Reperfusion Injury
Xanthine oxidase inhibition prevents mesenteric blood flow deficits after resuscitated hemorrhagic shock by preserving endothelial function.
Reperfusion Injury
Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine.
Reperfusion Injury
Xanthine oxidase mediates elastase-induced injury to isolated lungs and endothelium.
Reperfusion Injury
Xanthine oxidase produces hydrogen peroxide which contributes to reperfusion injury of ischemic, isolated, perfused rat hearts.
Reperfusion Injury
Xanthine oxidase: evidence against a causative role in renal reperfusion injury.
Reperfusion Injury
[Experimental study of injury on the small intestine in acute portal vein occlusion and the following restoration of portal vein flow in rats--hemodynamics and lipid peroxidation]
Reperfusion Injury
[Formation and removal of reactive oxygen species, lipid peroxides and free radicals, and their biological effects]
Reperfusion Injury
[Usefulness of allopurinol for prevention of myocardial reperfusion injury in open heart surgery]
Respiratory Distress Syndrome
Bronchoalveolar oxyradical inflammatory elements herald bronchopulmonary dysplasia.
Respiratory Insufficiency
Acute respiratory failure induced by tracheal instillation of xanthine oxidase, its prevention and therapy by exogenous surfactant instillation.
Respiratory Insufficiency
Respiratory failure caused by intratracheal saline: additive effect of xanthine oxidase.
Rheumatic Diseases
Effects of allopurinol on in vivo suppression of arthritis in mice and ex vivo modulation of phagocytic production of oxygen radicals in whole human blood.
Rheumatic Diseases
Elevated levels of xanthine oxidase in serum of patients with inflammatory and autoimmune rheumatic diseases.
Rheumatic Diseases
Kinetic study on the inhibition of xanthine oxidase by extracts from two selected Algerian plants traditionally used for the treatment of inflammatory diseases.
Rheumatic Diseases
Xanthine oxidase inhibitors from the leaves of Alsophila spinulosa (Hook) Tryon.
Rheumatic Diseases
Xanthine oxidase inhibitory activity of Lychnophora species from Brazil ("Arnica").
Seizures
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
Seizures
Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation.
Sepsis
Activities of xanthine oxidase and superoxide dismutase enzymes in rat intestinal tissues in sepsis.
Sepsis
Differential pathophysiology of bacterial translocation after thermal injury and sepsis.
Sepsis
Xanthine oxidase activity and free radical generation in patients with sepsis syndrome.
Sepsis
[Paeoniflorin Improves Acute Lung Injury in Sepsis by Activating Nrf2/Keap1 Signaling Pathway].
Sertoli Cell-Only Syndrome
The significance of testicular reactive oxygen species on testicular histology in infertile patients.
Shock, Septic
Xanthine oxidase activity and blood glutathione redox ratio in infants and children with septic shock syndrome.
Skin Neoplasms
Assessment of the antioxidant/prooxidant status of murine skin following topical treatment with 12-O-tetradecanoylphorbol-13-acetate and throughout the ontogeny of skin cancer. Part I: Quantitation of superoxide dismutase, catalase, glutathione peroxidase and xanthine oxidase.
Skin Ulcer
Hyperbaric oxygen therapy and free radical production: an experimental study in doxorubicin (Adriamycin) extravasation injuries.
Sleep Apnea, Obstructive
Xanthine Oxidase Inhibition Attenuates Endothelial Dysfunction Caused by Chronic Intermittent Hypoxia in Rats.
Spinal Cord Injuries
Altered oxidative stress and antioxidant defence in skeletal muscle during the first year following spinal cord injury.
Starvation
Extracellular superoxide provokes glutathione efflux from Escherichia coli cells.
Starvation
Imbalance of purine metabolism in hepatomas of different growth rates as expressed in behavior of xanthine oxidase (EC 1.2.3.2).
Stevens-Johnson Syndrome
Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells.
Stomach Neoplasms
Adenosine deaminase, 5'-nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in gastric juices from patients with gastric cancer, ulcer, and atrophic gastritis.
Stomach Ulcer
Effects of oxygen radical scavengers on the quality of gastric ulcer healing in rats.
Stomatitis
Prophylactic action of allopurinol against chemotherapy-induced stomatitis--inhibition of superoxide dismutase and proteases.
Stroke
Comparative evaluation of the acute effects of oxygen free radicals on myocardial contractility in anesthetized dogs with those occurring in the early stages of splanchnic artery occlusion and hemorrhagic shock.
Stroke
Dual inhibition of NADPH oxidases and xanthine oxidase potently prevents salt-induced stroke in stroke-prone spontaneously hypertensive rats.
Stroke
Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial.
Stroke
Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities.
Stroke
The Role of Xanthine Oxidase Inhibitors in Patients with History of Stroke: A Systematic Review.
Stroke
Urate-lowering therapy may mitigate the risks of hospitalized stroke and mortality in patients with gout.
Stroke
Xanthine oxidase inhibition for the improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) - Protocol for a randomised double blind placebo-controlled clinical trial.
Stroke
Xanthine oxidase inhibition for the treatment of stroke disease: a novel therapeutic approach.
Subarachnoid Hemorrhage
Production of uric acid in cerebrospinal fluid after subarachnoid hemorrhage in dogs: investigation of the possible role of xanthine oxidase in chronic vasospasm.
Subarachnoid Hemorrhage
[Clinical value of the sequential study of the uric acid in CSF in patients with cerebral diseases: Part I. Brain tumor and the effect of irradiation]
sulfite oxidase deficiency
Simultaneous occurrence of xanthine oxidase and sulfite oxidase deficiency. A molybdenum dependent inborn error of metabolism?
Sunburn
Nitric oxide and peroxynitrite released by ultraviolet B-irradiated human endothelial cells are possibly involved in skin erythema and inflammation.
Synovitis
Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content.
thiopurine s-methyltransferase deficiency
Azathioprine pharmacogenetics: the relationship between 6-thioguanine nucleotides and thiopurine methyltransferase in patients after heart and kidney transplantation.
Thromboembolism
Free radical scavenging mechanisms during pulmonary thromboembolism in rats.
Thrombosis
Xanthine oxidase mediates cyclic flow variations in a canine model of coronary arterial thrombosis.
Tuberculosis
Coadministration of Allopurinol To Increase Antimycobacterial Efficacy of Pyrazinamide as Evaluated in a Whole-Blood Bactericidal Activity Model.
Tumor Lysis Syndrome
Febuxostat-associated eosinophilic polymyositis in marginal zone lymphoma.
Tumor Lysis Syndrome
Hypouricemic effect and safety of febuxostat used for prevention of tumor lysis syndrome.
Tumor Lysis Syndrome
The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat.
Ureteral Obstruction
Febuxostat inhibits TGF??1?induced epithelial?mesenchymal transition via downregulation of USAG?1 expression in Madin?Darby canine kidney cells in vitro.
Urinary Bladder Neoplasms
Adenosine deaminase and xanthine oxidase activities in bladder washing fluid from patients with bladder cancer: a preliminary study.
Urinary Bladder Neoplasms
Adenosine deaminase, 5'nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in cancerous and noncancerous human bladder tissues.
Urinary Bladder Neoplasms
Lipid peroxidation and antioxidant enzyme activities in cancerous bladder tissue and their relation with bacterial infection: a controlled clinical study.
Urinary Bladder Neoplasms
Phloroglucinols inhibit chemical mediators and xanthine oxidase, and protect cisplatin-induced cell death by reducing reactive oxygen species in normal human urothelial and bladder cancer cells.
Urinary Bladder Neoplasms
Xanthine oxidase inhibitory terpenoids of Amentotaxus formosana protect cisplatin-induced cell death by reducing reactive oxygen species (ROS) in normal human urothelial and bladder cancer cells.
Urinary Tract Infections
New markers: urine xanthine oxidase and myeloperoxidase in the early detection of urinary tract infection.
Urogenital Diseases
Lipid peroxidation and antioxidant enzyme activities in cancerous bladder tissue and their relation with bacterial infection: a controlled clinical study.
Urolithiasis
Is there a role for uric acid in an animal model of calcium phosphate nephrocalcinosis and calcium phosphate crystallization in urine of patients with idiopathic calcium urolithiasis? An orientational study.
Urolithiasis
Potential cow milk xanthine oxidase inhibitory and antioxidant activity of selected phenolic acid derivatives.
Urolithiasis
Treatment of uric acid urolithiasis with allopurinol: a xanthine oxidase inhibitor.
Urolithiasis
[Xanthine urinary lithiasis and xanthinuria in a dachshund. Deficiency, probably genetic, of the xanthine oxidase system]
Uveitis
Free radical scavenging and antioxidant activity of allopurinol and oxypurinol in experimental lens-induced uveitis.
Varicocele
Nitric oxide synthase and xanthine oxidase activities in the spermatic vein of patients with varicocele: a potential role for nitric oxide and peroxynitrite in sperm dysfunction.
Vascular Diseases
Oxidative stress in atherogenesis and arterial thrombosis: the disconnect between cellular studies and clinical outcomes.
Vascular Diseases
Xanthine oxidase-derived extracellular superoxide anions stimulate activator protein 1 activity and hypertrophy in human vascular smooth muscle via c-Jun N-terminal kinase and p38 mitogen-activated protein kinases.
Vascular Ring
2,3-cis-Procyanidins Elicit Endothelium-Dependent Relaxation in Porcine Coronary Arteries via Activation of the PI3/Akt Kinase Signaling Pathway.
Vascular System Injuries
Angiopreventive versus angiopromoting effects of allopurinol in the murine sponge model.
Vascular System Injuries
Effects of endotoxin injury on endothelial cell adenosine metabolism.
Vascular System Injuries
Functional and structural alterations induced by copper in xanthine oxidase.
Vascular System Injuries
Ischemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals.
Vascular System Injuries
Sildenafil protects epithelial cell through the inhibition of xanthine oxidase and the impairment of ROS production.
Vasospasm, Intracranial
Production of uric acid in cerebrospinal fluid after subarachnoid hemorrhage in dogs: investigation of the possible role of xanthine oxidase in chronic vasospasm.
Ventricular Dysfunction, Left
Allopurinol improves cardiac dysfunction after ischemia-reperfusion via reduction of oxidative stress in isolated perfused rat hearts.
Ventricular Dysfunction, Left
Xanthine oxidase inhibition improves left ventricular dysfunction in dilated cardiomyopathic hamsters.
Ventricular Dysfunction, Left
Xanthine Oxidase Inhibition Prevents Atrial Fibrillation in a Canine Model of Atrial Pacing-Induced left Ventricular Dysfunction.
Virus Diseases
Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice.
Virus Diseases
Determination of human plasma xanthine oxidase activity by high-performance liquid chromatography.
Virus Diseases
Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers.
Virus Diseases
Reaction of xanthine oxidase-derived oxidants with lipid and protein of human plasma.
Vitamin B 12 Deficiency
[Orotic acid & xanthine oxidase of the liver in rats in vitamin B12 deficiency.]
Vitamin E Deficiency
Purification and characterization of xanthine oxidase from livers of vitamin E deficient rabbits.
Vitamin E Deficiency
Vitamin E deficiency: immunochemical evidence for increased accumulation of liver xanthine oxidase.
Wernicke Encephalopathy
Vascular factors in the neurotoxic damage caused by 1,3-dinitrobenzene in the rat.
Wound Infection
Differential pathophysiology of bacterial translocation after thermal injury and sepsis.
xanthine oxidase deficiency
Acute lymphocytic leukemia in a child with congenital xanthine oxidase deficiency: implications for therapy.
xanthine oxidase deficiency
Allopurinol metabolism in a patient with xanthine oxidase deficiency.
xanthine oxidase deficiency
Atmospheric pressure ionization mass spectrometry of purine and pyrimidine markers of inherited metabolic disorders.
xanthine oxidase deficiency
Clinicobiochemical analysis of four cases of xanthine oxidase deficiency.
xanthine oxidase deficiency
Combined deficiency of xanthine oxidase and sulphite oxidase: a defect of molybdenum metabolism or transport?
xanthine oxidase deficiency
Hereditary xanthine oxidase deficiency consisting of at least two subgroups.
xanthine oxidase deficiency
High-performance liquid chromatographic determination of hypoxanthine and xanthine in biological fluids.
xanthine oxidase deficiency
Measurement of xanthine oxidase activity in some human tissues. An optimized method.
xanthine oxidase deficiency
Metabolism of pyrazinamide and allopurinol in hereditary xanthine oxidase deficiency.
xanthine oxidase deficiency
Successful treatment of molybdenum cofactor deficiency type A with cPMP.
xanthine oxidase deficiency
The mass-spectrometirc identification of hypoxanthine and xanthine ('oxypurines') in skeletal musce from two patients with congenital xanthine oxidase deficiency (xanthinuria).
xanthine oxidase deficiency
The quantitative determination of hypoxanthine and xanthine ("oxypurines") in skeletal muscle from two patients with congenital xanthine oxidase deficiency (xanthinuria).
xanthine oxidase deficiency
Two-dimensional thin-layer chromatography for the screening of disorders of purine and pyrimidine metabolism.
xanthine oxidase deficiency
Uric acid, an important screening tool to detect inborn errors of metabolism: a case series.
xanthine oxidase deficiency
Urinary excretion of methylated purines in man and in the rat after the administration of theophylline.
xanthine oxidase deficiency
Xanthine oxidase deficiency and 'Dalmatian' hypouricaemia: incidence and effect of exercise.
xanthine oxidase deficiency
Xanthine oxidase deficiency: studies of a previously unreported case.
xanthine oxidase deficiency
Xanthine, hypoxanthine and muscle pain. Histochemical and biochemical observations.
xanthine oxidase deficiency
Xanthinuria: an additional case with demonstration of xanthine oxidase deficiency.
xanthine oxidase deficiency
[A case of asymptomatic xanthine oxidase deficiency (author's transl)]
xanthine oxidase deficiency
[A family of hereditary xanthinuria: two siblings with peptic ulcer and hypouricemia due to xanthine oxidase deficiency, and a heterozygote (father) with gout]
xanthine oxidase deficiency
[Combined sulfite and xanthine oxidase deficiency due to an anomaly in the metabolism of molybdenum cofactor]
xanthine oxidase deficiency
[Double deficiency of sulfite and xanthine oxidase causing encephalopathy and due to a hereditary anomaly in the metabolism of molybdenum]
xanthine oxidase deficiency
[Hematotoxicity caused by azathioprine genetically determined and aggravated by xanthine oxidase deficiency in a patient following renal transplantation]
xanthine oxidase deficiency
[Sulfite and xanthine oxidase deficiency: a diagnosis based on 2 simple tests]
xanthine oxidase deficiency
[Xanthine oxidase deficiency (hereditary xanthinuria), molybdenum cofactor deficiency]
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