Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 1.11.1.23 - (S)-2-hydroxypropylphosphonic acid epoxidase

for references in articles please use BRENDA:EC1.11.1.23

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate .

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
hpp epoxidase, (s)-2-hydroxypropylphosphonic acid epoxidase, ps-hppe, 2-hydroxypropylphosphonic acid epoxidase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-1,2-epoxypropylphosphonate + 2 H2O
show the reaction diagram
Highest Expressing Human Cell Lines
Cell Line Links Gene Links