Information on EC 1.11.1.5 - cytochrome-c peroxidase

Reaction Schemes

hideshow

2

ferrocytochrome c

+

H2O2

+

2

H+

=

2

ferricytochrome c

+

2

H2O

2

+

+

2

=

2

+

2

Synonyms
cytochrome c peroxidase, cytochrome-c peroxidase, diheme cytochrome c peroxidase, cytochrome peroxidase, apocytochrome c peroxidase, cjj0382, di-heme cytochrome c peroxidase, cytochrome c-551 peroxidase, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

apocytochrome c peroxidase

-

-

-

-

BCcP

Pseudomonas aeruginosa

P14532

-

702343

CCP

18 entries

CCP1

6 entries

CcpA

2 entries

Cjj0382

2 entries

CytC

Zymomonas mobilis

Q5NNF0

-

725756

cytochrome c iso-1

Saccharomyces cerevisiae

P00431

-

742511

cytochrome c peroxidase

13 entries

cytochrome c-551 peroxidase

-

-

-

-

cytochrome c-H2O oxidoreductase

-

-

-

-

cytochrome peroxidase

-

-

-

-

di-heme cytochrome c peroxidase

Paracoccus pantotrophus

-

-

677153

diheme cytochrome c peroxidase

2 entries

diheme cytochrome c5 peroxidase CcpA

2 entries

DocA

2 entries

LmP

Leishmania major

-

-

724335, 726385

MacA

2 entries

mesocytochrome c peroxidase azide

-

-

-

-

mesocytochrome c peroxidase cyanate

-

-

-

-

mesocytochrome c peroxidase cyanide

-

-

-

-

peroxidase, cytochrome c

-

-

-

-

Psa CcP

Pseudomonas aeruginosa

P14532

-

702343

CCP

-

-

-

-

CCP

Campylobacter jejuni

-

-

687074

CCP

Campylobacter jejuni 81-176

-

-

-

CCP

Escherichia coli

-

-

688857

CCP

Leishmania major

-

-

724335

CCP

Marinobacter nauticus

-

-

394632

CCP

Marinobacter nauticus 617

-

-

-

CCP

Nitrosomonas europaea

-

-

664002, 764157

CCP

Paracoccidioides brasiliensis

-

-

689117

CCP

Paracoccidioides brasiliensis Pb01 / ATCC MYA 826

-

-

-

CCP

Paracoccus pantotrophus

-

-

685251, 687816, 687825

CCP

Paracoccus pantotrophus LMD 52.44

-

-

-

CCP

Pseudomonas aeruginosa

-

-

664924, 688187

CCP

Pseudomonas aeruginosa

P14532

-

685208

CCP

Saccharomyces cerevisiae

-

-

685179, 685217, 702313, 724372, 724463, 724658, 742339

CCP

Saccharomyces cerevisiae

P00431

-

687792, 702250, 702294, 705132, 711231

CCP

Shewanella oneidensis

-

-

724366, 764157

CCP

Zymomonas mobilis

Q5NNF0

-

725756

CCP1

Candida albicans

-

-

742669

CCP1

Saccharomyces cerevisiae

-

-

686388, 725070, 765121

CCP1

Saccharomyces cerevisiae

P00431

-

764509

CCP1

Saccharomyces cerevisiae ATCC 204508

P00431

-

-

CCP1

Saccharomyces cerevisiae BY4741

-

-

-

CCP1

Saccharomyces cerevisiae K7-4

-

-

-

CcpA

Geobacter sulfurreducens

Q749D0

bacterial di-heme cytochrome c peroxidase

705165

CcpA

Shewanella oneidensis

-

-

724008

Cjj0382

Campylobacter jejuni

-

putative cytochrome c peroxidase

687074

Cjj0382

Campylobacter jejuni 81-176

-

putative cytochrome c peroxidase

-

cytochrome c peroxidase

-

-

-

-

cytochrome c peroxidase

Escherichia coli

-

-

685084, 688857

cytochrome c peroxidase

Geobacter sulfurreducens

Q749D0

-

705165

cytochrome c peroxidase

Leishmania major

-

-

724335

cytochrome c peroxidase

Paracoccus pantotrophus

-

-

685251, 687816, 687825

cytochrome c peroxidase

Paracoccus pantotrophus LMD 52.44

-

-

-

cytochrome c peroxidase

Pseudomonas aeruginosa

-

-

679215, 688187

cytochrome c peroxidase

Pseudomonas aeruginosa

P14532

-

685208, 702343

cytochrome c peroxidase

Saccharomyces cerevisiae

-

-

685217, 686388, 702313, 724372, 724463, 724658, 725645

cytochrome c peroxidase

Saccharomyces cerevisiae

P00431

-

687792, 702227, 702250, 702294, 705132

cytochrome c peroxidase

Saccharomyces cerevisiae Red Star

-

-

-

cytochrome c peroxidase

Shewanella oneidensis

-

-

724366

cytochrome c peroxidase

Zymomonas mobilis

Q5NNF0

-

725756

diheme cytochrome c peroxidase

Nitrosomonas europaea

P55929

-

675239

diheme cytochrome c peroxidase

Shewanella oneidensis

-

-

724008, 724366

diheme cytochrome c5 peroxidase CcpA

Nitrosomonas europaea

-

-

741922

diheme cytochrome c5 peroxidase CcpA

Shewanella oneidensis

Q8EF24

-

741922

DocA

Campylobacter jejuni

-

putative cytochrome c peroxidase

687074

DocA

Campylobacter jejuni 81-176

-

putative cytochrome c peroxidase

-

MacA

Geobacter sulfurreducens

Q74FY6

-

724337

MacA

Geobacter sulfurreducens DSM 12127

Q74FY6

-

-

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

2 ferrocytochrome c + H2O2 + 2 H+ = 2 ferricytochrome c + 2 H2O

8 entries

2 ferrocytochrome c + H2O2 + 2 H+ = 2 ferricytochrome c + 2 H2O

kinetics

Paracoccus denitrificans

-

394634

2 ferrocytochrome c + H2O2 + 2 H+ = 2 ferricytochrome c + 2 H2O

kinetics, energy, catalysis information

Saccharomyces cerevisiae

-

394630, 394631

2 ferrocytochrome c + H2O2 + 2 H+ = 2 ferricytochrome c + 2 H2O

reaction scheme

Pseudomonas aeruginosa

-

394609

2 ferrocytochrome c + H2O2 + 2 H+ = 2 ferricytochrome c + 2 H2O

pseudo-first-order kinetics

Pseudomonas stutzeri

-

659522

2 ferrocytochrome c + H2O2 + 2 H+ = 2 ferricytochrome c + 2 H2O

the enzyme uses hydrogen peroxide as an electron acceptor to oxidize cytochrome c. The enzyme is not essential for both cell viability and respiration. Its biological function is to reduce H2O2 generated during aerobic respiratory process. The enzyme may also act as a peroxynitrite scavenger

Saccharomyces cerevisiae

-

658180

2 ferrocytochrome c + H2O2 + 2 H+ = 2 ferricytochrome c + 2 H2O

only ferrocytochrome c bound at the Pelletier-Kraut site of enzyme is oxidized during turnover

Saccharomyces cerevisiae

-

672215

2 ferrocytochrome c + H2O2 + 2 H+ = 2 ferricytochrome c + 2 H2O

the intermediate Compound I forms once H2O2 is heterolytically cleaved, releasing a water molecule. The remaining O atom oxidizes the heme iron to Fe(IV) and an organic moiety to a cation radical. For most heme peroxidases, this moiety is the porphyrin ring. Upon two electron transfer events from two substrate molecules, the enzyme returns to the resting state with water occupying the active site

Leishmania major

-

724335

2 ferrocytochrome c + H2O2 + 2 H+ = 2 ferricytochrome c + 2 H2O

-

-

-

-

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

oxidation

-

-

-

-

redox reaction

-

-

-

-

reduction

-

-

-

-

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SYSTEMATIC NAME

IUBMB Comments

ferrocytochrome-c:hydrogen-peroxide oxidoreductase

A hemoprotein.

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CAS REGISTRY NUMBER

COMMENTARY

9029-53-2

-

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

1-methoxynaphthalene + H2O2

Russig's blue + 2 H2O

Saccharomyces cerevisiae

-

724658

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

11 entries

2 ferrocytochrome c + H2O2

2 ferricytochrome c + H2O

8 entries

2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2

?

Geobacter sulfurreducens

Q749D0

705165

Substrates: -
Products: -

?

2,2'-azino-bis(3-ethylenbenzthiazoline-6-sulfonic acid) + H2O2

?

2 entries

2,2-azinobis(3-ethylbenzthiazolinesulfonic acid) + H2O2

?

Shewanella oneidensis

-

724008

Substrates: -
Products: -

?

2-aminothiazole + H2O2

?

Saccharomyces cerevisiae

P00431

394628

Substrates: modified enzyme
Products: -

?

acrylonitrile + H2O2

? + H2O

Saccharomyces cerevisiae

-

741815

Substrates: -
Products: -

?

ascorbate + H2O2

dehydroascorbate + H2O

3 entries

azo violet + H2O2

? + H2O

Saccharomyces cerevisiae

-

742339

Substrates: -
Products: -

?

azurin + H2O2

oxidized azurin + ?

2 entries

brillant blue + H2O2

? + H2O

Saccharomyces cerevisiae

-

742339

Substrates: -
Products: -

?

cytochrome c + H2O2

?

3 entries

ferrocyanide + H2O2

ferricyanide + OH-

2 entries

ferrocytochrome c + CN-

?

Saccharomyces cerevisiae

-

657943

Substrates: dominant binding pathway for H52L mutant, biphasic reaction
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + 2 H2O

Saccharomyces cerevisiae

-

672215

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

31 entries

ferrocytochrome c + HCN

?

Saccharomyces cerevisiae

-

657943

Substrates: dominant binding pathway for wild-type enzyme
Products: -

?

ferrocytochrome c + menadione

ferricytochrome + oxidized menadione

Acidithiobacillus thiooxidans

-

394613

Substrates: menadione can be substituted by 1,4-naphthoquinone
Products: -

?

ferrocytochrome c2 + H2O2

ferricytochrome c2 + OH-

Rhodobacter capsulatus

-

394633

Substrates: -
Products: -

?

ferrocytochrome c4 + H2O2

ferricytochrome c4 + OH-

Pseudomonas denitrificans (nom. rej.)

-

394612

Substrates: -
Products: -

?

ferrocytochrome c550 + H2O2

ferricytochrome c550 + H2O

Paracoccus denitrificans

-

394634

Substrates: -
Products: -

r

ferrocytochrome c551 + H2O2

ferricytochrome c551 + OH-

2 entries

ferrocytochrome c552 + H2O2

ferricytochrome c552 + OH-

2 entries

ferrocytochrome c553 + H2O2

ferriytochrome c553 + OH-

Nitrosomonas europaea

-

394635

Substrates: -
Products: -

?

ferrocytochrome c555 + H2O2

ferricytochrome c555 + OH-

Paracoccus denitrificans

-

394634

Substrates: -
Products: -

?

ferrocytochrome c555 + H2O2

ferriytochrome c555 + OH-

Methylococcus capsulatus

-

394626

Substrates: -
Products: -

?

guaiacol + H2O2

2-methoxy-cyclohexa-2,5-dienone + H2O

3 entries

horse ferrocytochrome c + H2O2

horse ferricytochrome c + H2O

2 entries

horse heart ferrocytochrome c + H2O2

horse heart ferricytochrome c + H2O

4 entries

hydroquinone + H2O2

benzoquinone + H2O

2 entries

iso-1 ferrocytochrome c + H2O2

?

2 entries

iso-1 ferrocytochrome c mutant C102T + H2O2

iso-1 ferricytochrome c mutant C102T + 2 H2O

Saccharomyces cerevisiae

-

724463

Substrates: -
Products: -

?

iso-1-cytochrome c + ?

?

Saccharomyces cerevisiae

P00431

705132

Substrates: -
Products: -

?

isoniazid + H2O2

?

Saccharomyces cerevisiae

P00431

687792

Substrates: -
Products: -

?

NADH + H2O2

NAD+ + H2O

Acidithiobacillus thiooxidans

-

394613

Substrates: -
Products: -

?

NADPH + H2O2

NADP+ + H2O

Acidithiobacillus thiooxidans

-

394613

Substrates: -
Products: -

?

pyrogallol + H2O2

?

2 entries

Reactive Black 5 + H2O2

? + H2O

Saccharomyces cerevisiae

-

742339

Substrates: -
Products: -

?

reduced cytochrome c2 + H2O2

oxidized cytochrome c2 + H2O

2 entries

reduced cytochrome c551 + H2O2

oxidized cytochrome c551 + H2O

Pseudomonas aeruginosa

-

688187

Substrates: -
Products: -

?

reduced horse cytochrome c + H2O2

oxidized horse cytochrome c + H2O

2 entries

reduced pseudoazurin + H2O2

oxidized pseudoazurin + H2O

Paracoccus pantotrophus

-

687816

Substrates: -
Products: -

?

Rhodobacter capsulatus ferrocytochrome c + H2O2

Rhodobacter capsulatus ferricytochrome c + H2O

2 entries

Rhodobacter capsulatus ferrocytochrome c2 + H2O2

Rhodobacter capsulatus ferricytochrome c2 + H2O

2 entries

veratryl alcohol + H2O2

veratraldehyde + H2O

Saccharomyces cerevisiae

-

742339

Substrates: -
Products: -

?

yeast ferrocytochrome c + H2O2

yeast ferricytochrome c + H2O

Saccharomyces cerevisiae

-

660372

Substrates: -
Products: -

r

additional information

?

-

13 entries

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Leishmania major

-

724335, 726385

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Leishmania major

-

726385

Substrates: activity with wild-type cytochrome c from Leishmania major and reduced activity with mutant cytochrome c R24A and K98A, no activity with cyt c mutant R24A/K98A
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Nitrosomonas europaea

-

741922, 764157

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Saccharomyces cerevisiae

-

724463, 725645

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Saccharomyces cerevisiae

P00431

764509

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Saccharomyces cerevisiae

-

724463

Substrates: via intermediate compound I formation. The rate-limiting step in CcP compound I formation is the binding of hydrogen peroxide to the heme iron rather than the redox chemistry involved in compound I formation
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Saccharomyces cerevisiae ATCC 204508

P00431

764509

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Saccharomyces cerevisiae Red Star

-

725645

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Shewanella oneidensis

-

764157

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Shewanella oneidensis

Q8EF24

741922

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Zymomonas mobilis

Q5NNF0

725756

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + H2O

Geobacter sulfurreducens

Q749D0

705165

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + H2O

Marinobacter nauticus

-

394632

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + H2O

Marinobacter nauticus 617

-

394632

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + H2O

Nitrosomonas europaea

-

664002

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + H2O

Paracoccus denitrificans

-

663918

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + H2O

Paracoccus denitrificans

-

663915

Substrates: horse cytochrome c
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + H2O

Pseudomonas stutzeri

-

663915

Substrates: Pseudomonas aeruginosa cytochrome c-551
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + H2O

Pseudomonas stutzeri 9721

-

663915

Substrates: Pseudomonas aeruginosa cytochrome c-551
Products: -

?

2,2'-azino-bis(3-ethylenbenzthiazoline-6-sulfonic acid) + H2O2

?

Geobacter sulfurreducens

Q74FY6

724337

Substrates: -
Products: -

?

2,2'-azino-bis(3-ethylenbenzthiazoline-6-sulfonic acid) + H2O2

?

Geobacter sulfurreducens DSM 12127

Q74FY6

724337

Substrates: -
Products: -

?

ascorbate + H2O2

dehydroascorbate + H2O

Saccharomyces cerevisiae

-

394614, 394616

Substrates: -
Products: -

?

ascorbate + H2O2

dehydroascorbate + H2O

Saccharomyces cerevisiae

P00431

702227

Substrates: -
Products: -

?

ascorbate + H2O2

dehydroascorbate + H2O

Saccharomyces pastorianus

-

394614

Substrates: -
Products: -

?

azurin + H2O2

oxidized azurin + ?

Pseudomonas aeruginosa

-

394610

Substrates: blue copper protein
Products: -

?

azurin + H2O2

oxidized azurin + ?

Pseudomonas denitrificans (nom. rej.)

-

394612

Substrates: blue copper protein
Products: -

?

cytochrome c + H2O2

?

Saccharomyces cerevisiae

-

702313

Substrates: -
Products: -

?

cytochrome c + H2O2

?

Saccharomyces cerevisiae

P00431

702227, 702250

Substrates: -
Products: -

?

cytochrome c + H2O2

?

Saccharomyces cerevisiae

-

702313

Substrates: the reaction with hydrogen peroxide of the W51H/H52L mutant is much slower compared to those of the mutant W51H and W51H/H52W
Products: -

?

ferrocyanide + H2O2

ferricyanide + OH-

Saccharomyces cerevisiae

-

394614

Substrates: -
Products: -

?

ferrocyanide + H2O2

ferricyanide + OH-

Saccharomyces pastorianus

-

394614

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Acidithiobacillus thiooxidans

-

394613

Substrates: horse heart
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Campylobacter jejuni

-

687074

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Campylobacter jejuni 81-176

-

687074

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Cryptococcus neoformans

Q6URB0

658807

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Cryptococcus neoformans

Q6URB0

658807

Substrates: antioxidant defense
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Cryptococcus neoformans H99

Q6URB0

658807

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Cryptococcus neoformans H99

Q6URB0

658807

Substrates: antioxidant defense
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Escherichia coli

-

685084, 688857

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Neisseria gonorrhoeae

-

657830

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Nitrosomonas europaea

-

659313

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Paracoccus denitrificans

-

394634

Substrates: horse heart
Products: -

ir

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Paracoccus pantotrophus

-

685251

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Paracoccus pantotrophus LMD 52.44

-

685251

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Pseudomonas aeruginosa

-

679215

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Pseudomonas aeruginosa

P14532

685208, 702343

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Pseudomonas aeruginosa

-

702343

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Pseudomonas aeruginosa

-

394609

Substrates: horse heart
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Pseudomonas aeruginosa

P14532

702343

Substrates: investigation of the catalytic mechanism
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Pseudomonas stutzeri

-

659522

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Rhodobacter capsulatus

-

394633

Substrates: horse heart
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces cerevisiae

-

657943, 658180, 660372, 685217, 686388

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces cerevisiae

-

394630, 394631

Substrates: -
Products: -

ir

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces cerevisiae

-

394616

Substrates: -
Products: -

r

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces cerevisiae

P00431

687792, 702227

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces cerevisiae

P00431

394636

Substrates: -
Products: -

ir

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces cerevisiae

-

394614

Substrates: H2O2 can be substituted by ethyl peroxide
Products: -

ir

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces cerevisiae

-

394614

Substrates: yeast
Products: -

ir

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces cerevisiae

-

394614

Substrates: horse heart
Products: -

ir

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces pastorianus

-

394614

Substrates: H2O2 can be substituted by ethyl peroxide
Products: -

ir

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces pastorianus

-

394614

Substrates: yeast
Products: -

ir

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces pastorianus

-

394614

Substrates: horse heart
Products: -

ir

ferrocytochrome c551 + H2O2

ferricytochrome c551 + OH-

Pseudomonas aeruginosa

-

394610

Substrates: -
Products: -

?

ferrocytochrome c551 + H2O2

ferricytochrome c551 + OH-

Pseudomonas denitrificans (nom. rej.)

-

394612

Substrates: -
Products: -

?

ferrocytochrome c552 + H2O2

ferricytochrome c552 + OH-

Marinobacter nauticus

-

394632

Substrates: -
Products: -

?

ferrocytochrome c552 + H2O2

ferricytochrome c552 + OH-

Marinobacter nauticus 617

-

394632

Substrates: -
Products: -

?

guaiacol + H2O2

2-methoxy-cyclohexa-2,5-dienone + H2O

Saccharomyces cerevisiae

-

394614, 394616

Substrates: -
Products: -

?

guaiacol + H2O2

2-methoxy-cyclohexa-2,5-dienone + H2O

Saccharomyces cerevisiae

P00431

702227

Substrates: -
Products: -

?

guaiacol + H2O2

2-methoxy-cyclohexa-2,5-dienone + H2O

Saccharomyces pastorianus

-

394614

Substrates: -
Products: -

?

horse ferrocytochrome c + H2O2

horse ferricytochrome c + H2O

Rhodobacter capsulatus

-

664810

Substrates: -
Products: -

r

horse ferrocytochrome c + H2O2

horse ferricytochrome c + H2O

Rhodobacter capsulatus B10

-

664810

Substrates: -
Products: -

r

horse heart ferrocytochrome c + H2O2

horse heart ferricytochrome c + H2O

Paracoccidioides brasiliensis

-

689117

Substrates: -
Products: -

?

horse heart ferrocytochrome c + H2O2

horse heart ferricytochrome c + H2O

Paracoccidioides brasiliensis Pb01 / ATCC MYA 826

-

689117

Substrates: -
Products: -

?

horse heart ferrocytochrome c + H2O2

horse heart ferricytochrome c + H2O

Paracoccus pantotrophus

-

687825

Substrates: -
Products: -

?

horse heart ferrocytochrome c + H2O2

horse heart ferricytochrome c + H2O

Saccharomyces cerevisiae

-

660372

Substrates: -
Products: -

r

hydroquinone + H2O2

benzoquinone + H2O

Saccharomyces cerevisiae

-

394614

Substrates: -
Products: -

?

hydroquinone + H2O2

benzoquinone + H2O

Saccharomyces pastorianus

-

394614

Substrates: -
Products: -

?

iso-1 ferrocytochrome c + H2O2

?

Saccharomyces cerevisiae

-

685179

Substrates: -
Products: -

?

iso-1 ferrocytochrome c + H2O2

?

Saccharomyces cerevisiae

-

685217

Substrates: C102T
Products: -

?

pyrogallol + H2O2

?

Saccharomyces cerevisiae

-

394614, 394616

Substrates: -
Products: -

?

pyrogallol + H2O2

?

Saccharomyces pastorianus

-

394614

Substrates: -
Products: -

?

reduced cytochrome c2 + H2O2

oxidized cytochrome c2 + H2O

Rhodobacter capsulatus

-

664810

Substrates: -
Products: -

?

reduced cytochrome c2 + H2O2

oxidized cytochrome c2 + H2O

Rhodobacter capsulatus B10

-

664810

Substrates: -
Products: -

?

reduced horse cytochrome c + H2O2

oxidized horse cytochrome c + H2O

Rhodobacter capsulatus

-

664810

Substrates: -
Products: -

?

reduced horse cytochrome c + H2O2

oxidized horse cytochrome c + H2O

Rhodobacter capsulatus B10

-

664810

Substrates: -
Products: -

?

Rhodobacter capsulatus ferrocytochrome c + H2O2

Rhodobacter capsulatus ferricytochrome c + H2O

Rhodobacter capsulatus

-

664810

Substrates: -
Products: -

r

Rhodobacter capsulatus ferrocytochrome c + H2O2

Rhodobacter capsulatus ferricytochrome c + H2O

Rhodobacter capsulatus B10

-

664810

Substrates: -
Products: -

r

Rhodobacter capsulatus ferrocytochrome c2 + H2O2

Rhodobacter capsulatus ferricytochrome c2 + H2O

Rhodobacter capsulatus

-

664810

Substrates: -
Products: -

r

Rhodobacter capsulatus ferrocytochrome c2 + H2O2

Rhodobacter capsulatus ferricytochrome c2 + H2O

Rhodobacter capsulatus B10

-

664810

Substrates: -
Products: -

r

additional information

?

-

Leishmania major

-

724335

Substrates: Leishmania major peroxidase (LmP) exhibits both ascorbate and cytochrome c peroxidase activities, but cytochrome c is the natural substrate
Products: -

?

additional information

?

-

Leishmania major

-

724335

Substrates: Leishmania major cytochrome c has an electropositive surface surrounding the exposed heme edge that serves as the docking site with redox partners. Kinetic assays performed with Leishmania major cytochrome c and the enzyme show that it is a much better substrate for LmP than horse heart cytochrome c
Products: -

?

additional information

?

-

Saccharomyces cerevisiae

-

394614

Substrates: no oxidation of ferrocytochrome c of bacteria, no mammalian ferrocytochrome b, b5, c1
Products: -

?

additional information

?

-

Saccharomyces cerevisiae

-

686388

Substrates: Ccp1 functions as a terminal electron acceptor for sulfhydryl oxidase Erv1
Products: -

?

additional information

?

-

Saccharomyces cerevisiae

P00431

705132

Substrates: investigation of the binding hot-spot residue Y39 in the weak protein complex of physiological redox partners yeast iso-1-cytochrome c and cytochrome c peroxidase, cytochrome c and cytochrome c peroxidase binding parameters
Products: -

?

additional information

?

-

Saccharomyces cerevisiae

-

705132

Substrates: investigation of the binding hot-spot residue Y39 in the weak protein complex of physiological redox partners yeast iso-1-cytochrome c and cytochrome c peroxidase, cytochrome c and cytochrome c peroxidase binding parameters
Products: -

?

additional information

?

-

Saccharomyces cerevisiae

P00431

702294

Substrates: formation of a covalent link from Trp51 to the heme on reaction with H2O2
Products: -

?

additional information

?

-

Saccharomyces cerevisiae

P00431

702250

Substrates: investigation of an engineered channel mutant with the surrogate peptide (N-benzimidazole-propionic acid)-Gly-Ala-Ala (BzGAA), complete loss of functional activity in the BzGAA/ET channel mutant strongly supports proposals that the Trp-191 radical intermediate is required for efficient turnover of cyt c via the proposed ET pathway
Products: -

?

additional information

?

-

Saccharomyces cerevisiae

-

741897

Substrates: residues Tyr71 and Tyr236 contribute primarily to the EPR spectrum of the tyrosyl radical. The heme distal-side Trp51 is involved in the intramolecular electron transfer between Tyr71 and the heme and formation of Tyr71 and Tyr236 radicals is independent of the [Fe(IV)=O Trp191+] radical intermediate. Tyr71 radical is the reactive species with the guaiacol substrate. Surface-exposed residue Tyr236 is the other radical site
Products: -

?

additional information

?

-

Saccharomyces pastorianus

-

394614

Substrates: no oxidation of ferrocytochrome c of bacteria, no mammalian ferrocytochrome b, b5, c1
Products: -

?

additional information

?

-

Shewanella oneidensis

-

724008

Substrates: menaquinol pool-based origin of electrons that are transferred to CcpA
Products: -

?

additional information

?

-

Shewanella oneidensis

Q8EF24

741922

Substrates: the rate-limiting step involves a proton-coupled single electron reduction of a high valent iron species centered on the low-potential heme. Reduction shifts the pKa's of at least two amino acids. Loop 1 shifts during the rate-limiting step, changing the environment of residue His81
Products: -

?

additional information

?

-

Shewanella oneidensis

-

741922

Substrates: the rate-limiting step involves a proton-coupled single electron reduction of a high valent iron species centered on the low-potential heme. Reduction shifts the pKa's of at least two amino acids. Loop 1 shifts during the rate-limiting step, changing the environment of residue His81
Products: -

?

top print hide show all columns Go to Natural Substrate Search

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

8 entries

2 ferrocytochrome c + H2O2

2 ferricytochrome c + H2O

Geobacter sulfurreducens

Q749D0

705165

Substrates: -
Products: -

?

cytochrome c + H2O2

?

2 entries

ferrocytochrome c + H2O2

ferricytochrome c + H2O

8 entries

additional information

?

-

4 entries

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Leishmania major

-

724335, 726385

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Nitrosomonas europaea

-

764157

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Saccharomyces cerevisiae

-

724463, 725645

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Saccharomyces cerevisiae

P00431

764509

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Saccharomyces cerevisiae ATCC 204508

P00431

764509

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Saccharomyces cerevisiae Red Star

-

725645

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Shewanella oneidensis

-

764157

Substrates: -
Products: -

?

2 ferrocytochrome c + H2O2

2 ferricytochrome c + 2 H2O

Zymomonas mobilis

Q5NNF0

725756

Substrates: -
Products: -

?

cytochrome c + H2O2

?

Saccharomyces cerevisiae

-

702313

Substrates: -
Products: -

?

cytochrome c + H2O2

?

Saccharomyces cerevisiae

P00431

702250

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Cryptococcus neoformans

Q6URB0

658807

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Cryptococcus neoformans H99

Q6URB0

658807

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Neisseria gonorrhoeae

-

657830

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Nitrosomonas europaea

-

659313

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Pseudomonas aeruginosa

P14532

702343

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Pseudomonas stutzeri

-

659522

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces cerevisiae

-

657943, 658180, 660372

Substrates: -
Products: -

?

ferrocytochrome c + H2O2

ferricytochrome c + H2O

Saccharomyces cerevisiae

P00431

702227

Substrates: -
Products: -

?

additional information

?

-

Leishmania major

-

724335

Substrates: Leishmania major peroxidase (LmP) exhibits both ascorbate and cytochrome c peroxidase activities, but cytochrome c is the natural substrate
Products: -

?

additional information

?

-

Saccharomyces cerevisiae

P00431

705132

Substrates: investigation of the binding hot-spot residue Y39 in the weak protein complex of physiological redox partners yeast iso-1-cytochrome c and cytochrome c peroxidase, cytochrome c and cytochrome c peroxidase binding parameters
Products: -

?

additional information

?

-

Saccharomyces cerevisiae

-

705132

Substrates: investigation of the binding hot-spot residue Y39 in the weak protein complex of physiological redox partners yeast iso-1-cytochrome c and cytochrome c peroxidase, cytochrome c and cytochrome c peroxidase binding parameters
Products: -

?

additional information

?

-

Shewanella oneidensis

-

724008

Substrates: menaquinol pool-based origin of electrons that are transferred to CcpA
Products: -

?

top print hide show all columns Go to Cofactor Search

COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

cytochrome c

3 entries

heme

10 entries

cytochrome c

Saccharomyces cerevisiae

-

holo CcP binds cytochrome c with micromolar affinity. For apo CcP, the interaction with cytochrome c is completely abolished

741899

cytochrome c

Saccharomyces cerevisiae

P00431

study on both chemical shift perturbations and paramagnetic relaxation enhancements effects in the NMR spectrum of CcP generated in the presence of spin-labelled cytochrome c

742511

cytochrome c

Saccharomyces cerevisiae

P00431

thermodynamic affinity constants for binding the first and second cytochrome c are KI 0.0000001 per M, KII 0.0001 per M. Cytochrome c binds at the weaker-binding site with relatively great affinity, and places upper bounds on the contributions of repulsion between the two cytochrome c of the ternary complex

741907

heme

Saccharomyces cerevisiae

-

-

724372, 724463, 724658

heme

Leishmania major

-

-

726385

heme

Saccharomyces cerevisiae

P00431

-

711231

heme

Geobacter sulfurreducens

Q74FY6

-