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Information on EC - fatty-acid peroxygenase

for references in articles please use BRENDA:EC1.11.2.4
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EC Tree
     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.2 Peroxygenases
       fatty-acid peroxygenase
IUBMB Comments
A cytosolic heme-thiolate protein with sequence homology to P-450 monooxygenases. Unlike the latter, it needs neither NAD(P)H, dioxygen nor specific reductases for function. Enzymes of this type are produced by bacteria (e.g. Sphingomonas paucimobilis, Bacillus subtilis). Catalytic turnover rates are high compared with those of monooxygenation reactions as well as peroxide shunt reactions catalysed by the common P-450s. A model substrate is myristate, but other saturated and unsaturated fatty acids are also hydroxylated. Oxidizes the peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) and peroxygenates aromatic substrates in a fatty-acid-dependent reaction.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
p450foxy, cyp152a2, cyp152a1, cyp505, p450 peroxygenase, fatty-acid hydroxylase, p450bsbeta, peroxygenase p450, cyp152b1, cytochrome p450bsbeta, more
fatty acid + H2O2 = 3- or 2-hydroxy fatty acid + H2O
show the reaction diagram
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