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Information on EC 1.11.2.6 - L-tyrosine peroxygenase

for references in articles please use BRENDA:EC1.11.2.6

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IUBMB Comments

The enzyme from the bacterium Streptomyces lincolnensis participates in the biosynthesis of the antibiotic lincomycin A, while that from Streptomyces refuineus is involved in anthramycin biosynthesis. The enzyme, which contains a heme b cofactor, is rapidly inactivated in the presence of hydrogen peroxide, but the presence of L-tyrosine protects it. cf. EC 1.11.2.5, 3-methyl-L-tyrosine peroxygenase.

The expected taxonomic range for this enzyme is: Streptomyces
Reaction Schemes

Synonyms
lmbb2, l-tyrosine 3-hydroxylase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-tyrosine + H2O2 = L-dopa + H2O
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
lincomycin A biosynthesis, sibiromycin biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links