Disease on EC 1.13.11.31 - arachidonate 12-lipoxygenase

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Abortion, Spontaneous
Whole exome sequencing in recurrent early pregnancy loss.
Acute Coronary Syndrome
Platelet-derived 12-hydroxyeicosatetraenoic acid plays an important role in mediating canine coronary thrombosis by regulating platelet glycoprotein IIb/IIIa activation.
Acute Kidney Injury
A dual role of 12/15-lipoxygenase in LPS-induced acute renal inflammation and injury.
Acute Lung Injury
Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury.
Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).
ITRAQ-Based Proteomics Analysis of Acute Lung Injury Induced by Oleic Acid in Mice.
Adenocarcinoma
15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids.
5 alpha-reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids.
Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging.
Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer.
Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.
Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.
Adenocarcinoma of Lung
Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model.
Adenoma
Common polymorphisms in 5-lipoxygenase and 12-lipoxygenase genes and the risk of incident, sporadic colorectal adenoma.
Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps.
Oxylipin patterns in human colon adenomas.
Adenomatous Polyposis Coli
12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia.
Airway Obstruction
Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase.
Linoleic acid metabolite leads to steroid resistant asthma features partially through NF-?B.
Albuminuria
12/15-lipoxygenase inhibitors in diabetic nephropathy in the rat.
Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes.
Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes.
Alopecia
Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice.
Alzheimer Disease
12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.
12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.
5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease.
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism.
Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.
Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.
Benefits of neuropsychiatric phenomics: example of the 5-lipoxygenase-leptin-Alzheimer connection.
Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability.
Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment.
Mice deficient in L-12/15 lipoxygenase show increased vulnerability to 3-nitropropionic acid neurotoxicity.
Overexpression of 12/15-lipoxygenase increases anxiety behavior in female mice.
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
The 12-15-lipoxygenase is a modulator of Alzheimer's-related tau pathology in vivo.
The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease.
The Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene promoter is not associated with late onset Alzheimer disease.
Transcriptional regulation of ?-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments.
Amyloidosis
12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.
Amyotrophic Lateral Sclerosis
Combined Analysis of Phenotypic and Target-Based Screening in Assay Networks.
Anaphylaxis
Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.
Anemia
Inducible Endothelium-derived Hyperpolarizing Factor: Role of the 15-Lipoxygenase-EDHF Pathway.
Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6.
Regulation of cellular 15-lipoxygenase activity on pretranslational, translational, and posttranslational levels.
Aneurysm
miR-566 expression and immune changes in patients with intracranial aneurysm.
Angioedema
Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema.
arachidonate 12-lipoxygenase deficiency
12/15-Lipoxygenase Deficiency Impairs Neutrophil Granulopoiesis and Lung Proinflammatory Responses to Aspergillus fumigatus.
12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels.
12/15-Lipoxygenase Deficiency Reduces Densities of Mesenchymal Stem Cells in the Dermis of Wounded and Unwounded Skin.
12R-lipoxygenase deficiency disrupts epidermal barrier function.
Altered arachidonate metabolism by leukocytes and platelets in myeloproliferative disorders.
Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice.
Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators.
Decreased messenger RNA of arachidonate 12-lipoxygenase in platelets of patients with myeloproliferative disorders.
Development of myeloproliferative disease in 12/15-lipoxygenase deficiency.
Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies.
Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability.
Effects of cocaine in 5-lipoxygenase-deficient mice.
Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase.
Inhibition of 12/15-Lipoxygenase Reduces Renal Inflammation and Injury in Streptozotocin-Induced Diabetic Mice.
Leukotriene production by fresh human bone marrow cells: evidence of altered lipoxygenase activity in chronic myelocytic leukemia.
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia.
Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo.
Omega-3 fatty acids protect from colitis via an Alox15-derived eicosanoid.
Partially disturbed lamellar granule secretion in mild congenital ichthyosiform erythroderma with ALOX12B mutations.
Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis.
Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia.
Unbound Corneocyte Lipid Envelopes in 12R-Lipoxygenase Deficiency Support A Specific Role in Lipid-Protein Crosslinking.
Arthritis
12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis.
In vitro 12(S)-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi.
Involvement of 15-lipoxygenase in the inflammatory arthritis.
Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA.
Arthritis, Rheumatoid
Effects of a single dose of methotrexate on 5- and 12-lipoxygenase products in patients with rheumatoid arthritis.
Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.
Expression of arachidonate platelet-type 12-lipoxygenase in human rheumatoid arthritis type B synoviocytes.
Interleukin-8 secretion and 15-lipoxygenase activity in rheumatoid arthritis: in vitro anti-inflammatory effects by interleukin-4 and interleukin-10, but not by interleukin-1 receptor antagonist protein.
Systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb folium eriobotryae.
The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation.
Aspergillosis
12/15-Lipoxygenase Deficiency Impairs Neutrophil Granulopoiesis and Lung Proinflammatory Responses to Aspergillus fumigatus.
Asthma
12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.
15-lipoxygenase immunoreactivity in normal and in asthmatic airways.
15-lipoxygenase metabolites play an important role in the development of a T-helper type 1 allergic inflammation induced by double-stranded RNA.
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population.
A Cell-based Assay for Screening Lipoxygenase Inhibitors.
ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma.
ALOX5 promoter genotype and response to montelukast in moderate persistent asthma.
ALOX5 promoter genotype, asthma severity and LTC production by eosinophils.
Arachidonic Acid 15-Lipoxygenase: Effects of Its Expression, Metabolites, and Genetic and Epigenetic Variations on Airway Inflammation.
Association of the -1072G/A Polymorphism in the LTC4S Gene with Asthma in an Indian Population.
Candidate gene analysis of asthma in a population of Arab descent: a case-control study in Jordan.
Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies.
Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model.
Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis.
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Eoxins: a new inflammatory pathway in childhood asthma.
Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition.
Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma: A Randomized Trial.
Foxa2 Regulates Leukotrienes to Inhibit Th2-mediated Pulmonary Inflammation.
Functional classes of bronchial mucosa genes that are differentially expressed in asthma.
Gene expression profiling in human asthma.
Genetic mechanism of aspirin-induced urticaria/angioedema.
Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues.
Genome-wide analysis revealed sex-specific gene expression in asthmatics.
Histochemical evidence for induction of arachidonate 15-lipoxygenase in airway disease.
Identification of differentially expressed genes in childhood asthma.
Implications of pharmacogenomics in the current and future treatment of asthma.
Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial.
Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells.
Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma.
Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34(+)CD38(-) stem and progenitor cells in chronic myeloid leukemia.
Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirin-intolerant asthma: differing contributions of ALOX5 polymorphism in Korean population.
Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): Rationale and methods.
Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment.
Pharmacogenetic Factors Affecting Asthma Treatment Response. Potential Implications for Drug Therapy.
Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast.
Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population.
Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.
Reversed changes of lipoxin A4 and leukotrienes in children with asthma in different severity degree.
Single-Cell RNA Sequencing Reveals a Unique Monocyte Population in Bronchoalveolar Lavage Cells of Mice Challenged With Afghanistan Particulate Matter and Allergen.
Substituted (E)-2-(2-benzylidenehydrazinyl)-4-methylthiazole-5-carboxylates as dual inhibitors of 15-lipoxygenase & carbonic anhydrase II: synthesis, biochemical evaluation and docking studies.
Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models.
[Effects of dexamethasone on 15-lipoxygenase expression in lungs of asthmatic rats.]
[Reversed changes of the 15-lipoxygenase product lipoxin A? and the 5-lipoxygenase product leukotriene C? in children with asthma].
Asthma, Exercise-Induced
Transcription in response to physical stress--clues to the molecular mechanisms of exercise-induced asthma.
Atherosclerosis
αM{beta}2 Integrin Activation Prevents Alternative Activation of Human and Murine Macrophages and Impedes Foam Cell Formation.
12/15 lipoxygenase mediates monocyte adhesion to aortic endothelium in apolipoprotein E-deficient mice through activation of RhoA and NF-kappaB.
12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1.
12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo.
12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway.
12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice.
12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice.
12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction.
12/15-Lipoxygenase Products Induce Inflammation and Impair Insulin Signaling in 3T3-L1 Adipocytes.
12/15-lipoxygenase regulates intercellular adhesion molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor-kappaB.
12/15-lipoxygenase, oxidative modification of LDL and atherogenesis.
15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness.
15-Lipoxygenase induction as an index of oxidative stress and atherogenesis.
15-Lipoxygenase inhibitors as anti-atherosclerosis agents.
15-oxoeicosatetraenoic acid mediates monocyte adhesion to endothelial cell.
5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease.
5-Lipoxygenase Gene Variants Are Not Associated With Atherosclerosis or Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis Cohort.
6-substituted purines as inhibitors of 15-lipoxygenase; a structure-activity study.
?(9)-tetrahydrocannabinol and its major metabolite ?(9)-tetrahydrocannabinol-11-oic acid as 15-lipoxygenase inhibitors.
A functional Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene is not associated with myocardial infarction.
A hyperresponsive 15-lipoxygenase phenotype in rabbit and human populations: relationship to atherosclerosis.
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.
A possible role for 15-lipoxygenase in atherogenesis.
A primary determinant for lipoxygenase positional specificity.
A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit.
Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice.
Activation of NADPH oxidase required for macrophage-mediated oxidation of low-density lipoprotein.
Aldosterone up-regulates 12- and 15-lipoxygenase expression and LDL oxidation in human vascular smooth muscle cells.
ALOX12 In Human Toxoplasmosis.
Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.
Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis.
Association of ALOX15 Gene Polymorphism with Ischemic Stroke in Northern Chinese Han Population.
Association of polymorphisms in the ALOX15B gene with coronary artery disease.
Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators.
Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties.
Cannabidiol-2',6'-dimethyl Ether as an Effective Protector of 15-Lipoxygenase-Mediated Low-Density Lipoprotein Oxidation in Vitro.
Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation.
Cellular and molecular mechanisms of the selective regulation of IL-12 production by 12/15-lipoxygenase.
Characterization of a human 12/15-lipoxygenase promoter variant associated with atherosclerosis identifies vimentin as a promoter binding protein.
Cholesteryl ester acyl oxidation and remodeling in murine macrophages: formation of oxidized phosphatidylcholine.
Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets.
Comparative effect of lipoxygenase products of arachidonic acid on rat aortic smooth muscle cell migration.
Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice.
CTRP5 promotes transcytosis and oxidative modification of low-density lipoprotein and the development of atherosclerosis.
Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice.
Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice.
Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.
Eicosanoids and Docosanoids in Plasma and Aorta of Healthy and Atherosclerotic Rabbits.
Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice.
Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats.
Epigenetics and atherosclerosis.
Essential involvement of 12-lipoxygenase in regiospecific andstereospecific oxidation of low density lipoprotein by macrophages.
Evidence that increased 12-lipoxygenase activity induces apoptosis in fibroblasts.
Expression and regulation of 12/15-lipoxygenases in human primary macrophages.
Expression of 12/15-lipoxygenase attenuates intracellular lipid deposition during in vitro foam cell formation.
Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.
Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.
Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children.
Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking.
High density lipoprotein inhibits platelet 12-lipoxygenase activity.
High expression of human 15-lipoxygenase induces NF-kappaB-mediated expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and T-cell adhesion on human endothelial cells.
Human 15-lipoxygenase: induction by interleukin-4 and insights into positional specificity.
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
In vitro 12(S)-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi.
In vivo action of 15-lipoxygenase in early stages of human atherogenesis.
Indolizines as novel potent inhibitors of 15-lipoxygenase.
Inducible Endothelium-derived Hyperpolarizing Factor: Role of the 15-Lipoxygenase-EDHF Pathway.
Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.
Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions.
Inflammation and immune regulation by 12/15-lipoxygenases.
Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways.
Inhibition of leukocyte-type 12-lipoxygenase by guava tea leaves prevents development of atherosclerosis.
Interaction between ALOX15 polymorphisms and coronary artery disease in North Indian population.
Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease.
Involvement of 15-lipoxygenase in early stages of atherogenesis.
Is there a role for 15-lipoxygenase in atherogenesis?
Lipid metabolism: 5-lipoxygenase, 12/15-lipoxygenase, and atherogenesis.
Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease.
Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12-lipoxygenase, 15-lipoxygenase and leukotriene receptor antagonists.
Lipoxygenase products increase monocyte adhesion to human aortic endothelial cells.
Lipoxygenases and lipid signaling in vascular cells in diabetes.
Low density lipoprotein receptor-related protein is required for macrophage-mediated oxidation of low density lipoprotein by 12/15-lipoxygenase.
Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.
Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.
Macrophages and oxidized low density lipoproteins in the pathogenesis of atherosclerosis.
Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways.
No association of two functional polymorphisms in human ALOX15 with myocardial infarction.
Nutrigenetic Disruption of Inflammation-Resolution Homeostasis and Atherogenesis.
Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice.
Oxidation of free fatty acids in low density lipoprotein by 15-lipoxygenase stimulates nonenzymic, alpha-tocopherol-mediated peroxidation of cholesteryl esters.
Oxidation of LDL by recombinant human 15-lipoxygenase: evidence for alpha-tocopherol-dependent oxidation of esterified core and surface lipids.
Paradoxical increase in LDL oxidation by endothelial cells from an atherosclerosis-resistant mouse strain.
Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors.
Platelets stimulate aortic smooth muscle cell migration in vitro. Involvement of 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid.
Pro-resolving lipid mediators in the resolution of neointimal hyperplasia pathogenesis in atherosclerotic diseases.
Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis.
Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.
Reduced growth factor responses in vascular smooth muscle cells derived from 12/15-lipoxygenase-deficient mice.
Regulation of human 12/15-lipoxygenase by Stat6-dependent transcription.
Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor-kappa B (NF-kappa B).
Relationship of vascular 15-lipoxygenase induction to atherosclerotic plaque formation in rabbits.
Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model.
Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.
ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation.
Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia.
Selective uptake and efflux of cholesteryl linoleate in LDL by macrophages expressing 12/15-lipoxygenase.
Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice.
Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.
Structure elucidation of oxygenated lipids in human atherosclerotic lesions.
Systemic activation of 15-lipoxygenase in heart, lung, and vascular tissues by hypercholesterolemia: relationship to lipoprotein oxidation and atherogenesis.
The arachidonate 12/15 lipoxygenases. A review of tissue expression and biologic function.
The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages.
The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions.
The role of lipoxygenase-isoforms in atherogenesis.
The Transcription Factor CREB Enhances Interleukin-17A Production and Inflammation in a Mouse Model of Atherosclerosis.
The two faces of the 15-lipoxygenase in atherosclerosis.
Transgenic rabbits with the integrated human 15-lipoxygenase gene driven by a lysozyme promoter: macrophage-specific expression and variable positional specificity of the transgenic enzyme.
Transient experimental anemia in cholesterol-fed rabbits induces systemic overexpression of the reticulocyte-type 15-lipoxygenase and protects from aortic lipid deposition.
Transient overexpression of human 15-lipoxygenase in aortic endothelial cells enhances tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression.
Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population.
Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: The Athero-Express Genomics Study.
Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice.
[Leukotriene-lipoxygenase pathway and drug discovery]
Autoimmune Diseases
12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance.
12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function.
Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPAR?/?: a potential therapeutic role for CNS autoimmune disease.
Bacteremia
Systemic Disease during Streptococcus pneumoniae Acute Lung Infection Requires 12-Lipoxygenase-Dependent Inflammation.
Barrett Esophagus
Platelet 12-lipoxygenase and stem cells in Barrett's esophagus.
Blast Crisis
Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at diagnosis of chronic myeloid leukemia.
Blister
Altered epididymal sperm maturation and cytoplasmic droplet migration in subfertile male Alox15 mice.
Partially disturbed lamellar granule secretion in mild congenital ichthyosiform erythroderma with ALOX12B mutations.
Bone Resorption
The effect of Lipoxin A4 on the interaction between macrophage and osteoblast: possible role in the treatment of aseptic loosening.
Brain Diseases
12/15 Lipoxygenase as a Therapeutic Target in Brain Disorders.
Exploring the molecular approach of COX and LOX in Alzheimer's and Parkinson's disorder.
Brain Edema
Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Brain Injuries
12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress.
Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia.
Potent and Selective Inhibitors of Human Reticulocyte 12/15- Lipoxygenase as Anti-Stroke Therapies.
Brain Injuries, Traumatic
Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury.
Brain Ischemia
Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia.
Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: down-regulated 12/15-LOX, p38MAPK and cPLA2 expression, ameliorated BBB permeability.
Neuroprotection of taurine through inhibition of 12/15 lipoxygenase pathway in cerebral ischemia of rats.
Breast Neoplasms
5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic Acid, and risk for breast cancer.
A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway.
Aberrant ALOX5 Activation Correlates with HER2 Status and Mediates Breast Cancer Biological Activities through Multiple Mechanisms.
ALOX12 inhibition sensitizes breast cancer to chemotherapy via AMPK activation and inhibition of lipid synthesis.
ALOX12B promotes carcinogenesis in cervical cancer by regulating the PI3K/ERK1 signaling pathway.
Association of a functional polymorphism (Gln261Arg) in 12-lipoxygenase with breast cancer.
Associations between ALOX, COX, and CRP polymorphisms and breast cancer among Hispanic and non-Hispanic white women: The breast cancer health disparities study.
Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women.
Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGF alpha/EGF.
COX-2 expression in invasive breast cancer: correlation with prognostic parameters and outcome.
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.
Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice.
Evaluation of human LOX-12 as a serum marker for breast cancer.
Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: impact on prognosis and therapy.
Genetic Variants in COX2 and ALOX Genes and Breast Cancer Risk in White and Black Women.
Increased 12-lipoxygenase expression in breast cancer tissues and cells. Regulation by epidermal growth factor.
Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer.
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma.
Oleic acid induces migration through a FFAR1/4, EGFR and Akt-dependent pathway in breast cancer cells.
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer.
Role of lipoxygenases in breast cancer.
Serum 5-LOX: a progressive protein marker for breast cancer and new approach for therapeutic target.
Structure Based Design and Synthesis of Peptide Inhibitor of Human LOX-12: In Vitro and In Vivo Analysis of a Novel Therapeutic Agent for Breast Cancer.
Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation.
The 12-lipoxygenase gene-transfected MCF-7 human breast cancer cell line exhibits estrogen-independent, but estrogen and omega-6 fatty acid-stimulated proliferation in vitro, and enhanced growth in athymic nude mice.
The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells.
Bronchitis
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Bronchitis, Chronic
15(S)-HETE modulates LTB(4) production and neutrophil chemotaxis in chronic bronchitis.
Gene expression and immunolocalization of 15-lipoxygenase isozymes in the airway mucosa of smokers with chronic bronchitis.
Histochemical evidence for induction of arachidonate 15-lipoxygenase in airway disease.
Substituted (E)-2-(2-benzylidenehydrazinyl)-4-methylthiazole-5-carboxylates as dual inhibitors of 15-lipoxygenase & carbonic anhydrase II: synthesis, biochemical evaluation and docking studies.
Carcinogenesis
12-Lipoxygenase promotes invasion and metastasis of human gastric cancer cells via epithelial-mesenchymal transition.
12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models.
15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids.
5-Lipoxygenase is a direct p53 target gene in humans.
5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage.
A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway.
Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by 15S-hydroxyeicosatrienoic acid parallels growth suppression of androgen-dependent prostatic adenocarcinoma cells.
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.
ALOX12B promotes carcinogenesis in cervical cancer by regulating the PI3K/ERK1 signaling pathway.
ALOX15 as a suppressor of inflammation and cancer: Lost in the link.
Antitumor Activities of Ethyl Acetate Extracts from Selaginella doederleinii Hieron In Vitro and In Vivo and Its Possible Mechanism.
Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms.
Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis.
Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma.
Inhibition of carcinogenesis in transgenic mouse models over-expressing 15-lipoxygenase in the vascular wall under the control of murine preproendothelin-1 promoter.
Lipoxygenase metabolism: roles in tumor progression and survival.
Lipoxygenase modulation to reverse carcinogenesis.
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma.
Orthotopic expression of human 15-lipoxygenase (LO)-1 in the dorsolateral prostate of normal wild-type C57BL/6 mouse causes PIN-like lesions.
Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.
Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency.
Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer.
Profiling lipoxygenase metabolism in specific steps of colorectal tumorigenesis.
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Role of 'platelet-type' 12-lipoxygenase in skin carcinogenesis.
The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis.
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
The possible involvement of 15-lipoxygenase/leukocyte type 12-lipoxygenase in colorectal carcinogenesis.
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer.
What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?
Carcinoma
12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha.
12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-?B pathway in ovarian cancer.
12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes.
12-lipoxygenase promotes tumor progress by TGF-?1-mediated epithelial to mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.
5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway.
?-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors.
Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism.
Eicosanoid regulation of angiogenesis in tumors.
Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma.
Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.
Evaluation of 12-lipoxygenase (12-LOX) and plasminogen activator inhibitor 1 (PAI-1) as prognostic markers in prostate cancer.
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.
Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma.
Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential.
Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase.
Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis.
Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells.
Inverse regulation of lipid-peroxidizing and hydroperoxyl lipid-reducing enzymes by interleukins 4 and 13.
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma.
Multiple use of a signal transduction pathway in tumor cell invasion.
Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.
Phospho-?Np63? regulates AQP3, ALOX12B, CASP14 and CLDN1 expression through transcription and microRNA modulation.
Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.
Platelet-type 12- lipoxygenase induces MMP9 expression and cellular invasion via activation of PI3K/AKT/NF-?B.
Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.
Platelet-type 12-lipoxygenase regulates angiogenesis in human prostate carcinoma.
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Reduced expression of 15-lipoxygenase 2 in human head and neck carcinomas.
Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4.
Regulation of apoptosis through arachidonate cascade in mammalian cells.
Regulation of monoamine oxidase A (MAO-A) expression, activity, and function in IL-13-stimulated monocytes and A549 lung carcinoma cells.
Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival.
Specific overexpression of 15-lipoxygenase in endothelial cells promotes cancer cell death in an in vivo Lewis lung carcinoma mouse model.
[Association of genetic variant in 12-lipoxygenase and risk of hepatic carcinoma].
Carcinoma, Ductal
Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer.
Carcinoma, Hepatocellular
15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation.
Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy.
Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo.
Carcinoma, Lewis Lung
12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes.
Specific overexpression of 15-lipoxygenase in endothelial cells promotes cancer cell death in an in vivo Lewis lung carcinoma mouse model.
Carcinoma, Lobular
Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer.
Carcinoma, Non-Small-Cell Lung
Regulation of monoamine oxidase A (MAO-A) expression, activity, and function in IL-13-stimulated monocytes and A549 lung carcinoma cells.
Carcinoma, Ovarian Epithelial
Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival.
Carcinoma, Renal Cell
5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway.
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.
Carcinoma, Squamous Cell
12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization.
ALOX12B promotes carcinogenesis in cervical cancer by regulating the PI3K/ERK1 signaling pathway.
Attenuation of c-Jun and Sp1 expression and p300 recruitment to gene promoter confers the trichostatin A-induced inhibition of 12(S)-lipoxygenase expression in EGF-treated A431 cells.
Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells.
Down-regulation of epidermal growth factor-induced 12-lipoxygenase expression by glucocorticoids in human epidermoid carcinoma A431 cells.
Epidermal growth factor enhances transcription of human arachidonate 12-lipoxygenase in A431 cells.
Essential role of mitogen-activated protein kinase pathway and c-Jun induction in epidermal growth factor-induced gene expression of human 12-lipoxygenase.
Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma.
Functional interaction between c-Jun and promoter factor Sp1 in epidermal growth factor-induced gene expression of human 12(S)-lipoxygenase.
Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene.
Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.
Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells.
Induction of 12-lipoxygenase expression by phorbol 12-myristate 13-acetate in human epidermoid carcinoma A431 cells.
Induction of 12-lipoxygenase expression by transforming growth factor-alpha in human epidermoid carcinoma A431 cells.
Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells.
Inhibition of 12-LOX and COX-2 reduces the proliferation of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-Akt signalling pathways.
Lipoxygenase pathway of arachidonic acid metabolism in growth control of tumor cells of different type.
Overexpression of c-Fos enhances the transcription of human arachidonate 12-lipoxygenase in A431 cells.
Overexpression of Ha-ras enhances the transcription of human arachidonate 12-lipoxygenase promoter in A431 cells.
Phospho-?Np63? regulates AQP3, ALOX12B, CASP14 and CLDN1 expression through transcription and microRNA modulation.
Regulation of 12-lipoxygenase expression by epidermal growth factor in human epidermoid carcinoma A431 cells.
Requirement for epidermal growth factor receptor tyrosine kinase and for 12-lipoxygenase activity in the expression of 12-lipoxygenase in human epidermoid carcinoma cells.
Transcription factor Sp1 functions as an anchor protein in gene transcription of human 12(S)-lipoxygenase.
Transcriptional activation of human 12-lipoxygenase gene promoter is mediated through Sp1 consensus sites in A431 cells.
Carcinosarcoma
Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and depletion of GSH: role of 12-lipoxygenase in regulating tumor cell survival.
Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.
Overexpression of leukocyte-type 12-lipoxygenase promotes W256 tumor cell survival by enhancing alphavbeta5 expression.
Cardiovascular Diseases
12-Lipoxygenase metabolism in mouse distal convoluted tubule cells.
A Cell-based Assay for Screening Lipoxygenase Inhibitors.
A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE.
Distinctive Under-Expression Profile of Inflammatory and Redox Genes in the Blood of Elderly Patients with Cardiovascular Disease.
Impact of Age, Menopause, and Obesity on Oxylipins Linked to Vascular Health.
The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases.
Carotid Stenosis
Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generation.
Cataract
A role for 12(S)-HETE in the response of human lens epithelial cells to epidermal growth factor and insulin.
Cerebral Hemorrhage
A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population.
Activation of peroxisome proliferator-activated receptor-? by a 12/15-lipoxygenase product of arachidonic acid: a possible neuroprotective effect in the brain after experimental intracerebral hemorrhage.
Cerebral Infarction
Key role of 15-LO/15-HETE in angiogenesis and functional recovery in later stages of post-stroke mice.
Cholesteatoma
Quantitative measurement of m-RNA levels to assess expression of cyclooxygenase-II, inducible nitric oxide synthase and 12-lipoxygenase genes in middle ear cholesteatoma.
Cholesteatoma, Middle Ear
Quantitative measurement of m-RNA levels to assess expression of cyclooxygenase-II, inducible nitric oxide synthase and 12-lipoxygenase genes in middle ear cholesteatoma.
Chronic Periodontitis
Effect of Alox-15 Polymorphism on GCF Levels of Lipoxin-A4 in Chronic Periodontitis: A Preliminary Study.
Impaired polymorphonuclear leukocyte 15-lipoxygenase activity in juvenile and rapidly progressive periodontitis.
Colitis
ALOX15 as a suppressor of inflammation and cancer: Lost in the link.
Female mice carrying a defective Alox15 gene are protected from experimental colitis via sustained maintenance of the intestinal epithelial barrier function.
Lipoxin biosynthesis in inflammatory bowel disease.
Omega-3 fatty acids protect from colitis via an Alox15-derived eicosanoid.
Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection.
Colitis, Ulcerative
Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease.
Colonic Neoplasms
Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.
Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells.
Nox1 downstream of 12-lipoxygenase controls cell proliferation but not cell spreading of colon cancer cells.
Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase.
PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer.
The polymorphism (Gln261Arg) of 12-lipoxygenase and cancer risk: a meta-analysis.
Colorectal Neoplasms
15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway.
ALOX15 as a suppressor of inflammation and cancer: Lost in the link.
Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme.
Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.
Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells.
Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cells during apoptosis and cell differentiation.
Expression of 15-lipoxygenase-1 in human colorectal cancer.
Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.
MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5.
Non-synonymous polymorphism (Gln261Arg) of 12-lipoxygenase in colorectal and thyroid cancers.
Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer.
The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer.
Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells.
Coronary Artery Disease
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.
Association of polymorphisms in the ALOX15B gene with coronary artery disease.
Association of Sp1 tandem repeat polymorphism of ALOX5 with coronary artery disease in Indian subjects.
Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease.
Expression of 15-lipoxygenase in transplant coronary artery disease.
Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children.
Immunohistochemical demonstration of 15-lipoxygenase in transplant coronary artery disease.
Interaction between ALOX15 polymorphisms and coronary artery disease in North Indian population.
Lipoxygenase pathways in atherogenesis.
Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease.
No association of two functional polymorphisms in human ALOX15 with myocardial infarction.
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3.
Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population.
Coronary Disease
5-Lipoxygenase Gene Variants Are Not Associated With Atherosclerosis or Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis Cohort.
Inhibitory effect of flavonoids on low-density lipoprotein peroxidation catalyzed by mammalian 15-lipoxygenase.
Cough
Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase.
COVID-19
LTB4-Driven Inflammation and Increased Expression of ALOX5/ACE2 During Severe COVID-19 in Individuals With Diabetes.
Crohn Disease
Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease.
Cystic Fibrosis
Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency.
Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis.
Reverse transcription-polymerase chain reaction (RT-PCR) phenotypic analysis of cell cultures of human tracheal epithelium, tracheobronchial glands, and lung carcinomas.
Cystitis
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Dementia
Benefits of neuropsychiatric phenomics: example of the 5-lipoxygenase-leptin-Alzheimer connection.
Dermatitis
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Dermatitis, Exfoliative
A novel mutation in the 12(R)-lipoxygenase (ALOX12B) gene underlies nonbullous congenital ichthyosiform erythroderma.
Congenital ichthyosiform erythroderma with a novel variant in ABCA12 in a Chinese patient.
Different TGM1 mutation spectra in Italian and Portuguese patients with autosomal recessive congenital ichthyosis: evidence of founder effects in Portugal.
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.
Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.
Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis.
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.
Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.
Partially disturbed lamellar granule secretion in mild congenital ichthyosiform erythroderma with ALOX12B mutations.
Self-healing collodion membrane and mild nonbullous congenital ichthyosiform erythroderma due to 2 novel mutations in the ALOX12B gene.
Diabetes Complications
Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications.
Diabetes Mellitus
12(S)-HETE impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose-induced vascular injury.
12/15-lipoxygenase inhibitors in diabetic nephropathy in the rat.
Association of genetic variants with myocardial infarction in individuals with or without hypertension or diabetes mellitus.
Baicalein Alleviates Erectile Dysfunction Associated With Streptozotocin-Induced Type I Diabetes by Ameliorating Endothelial Nitric Oxide Synthase Dysfunction, Inhibiting Oxidative Stress and Fibrosis.
Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells.
Evaluation of the oxidative stress-related genes ALOX5, ALOX5AP, GPX1, GPX3 and MPO for contribution to the risk of type 2 diabetes mellitus in the Han Chinese population.
Increased 12/15-Lipoxygenase Enhances Cell Growth, Fibronectin Deposition, and Neointimal Formation in Response to Carotid Injury.
RAGE and CYBA polymorphisms are associated with microalbuminuria and end-stage renal disease onset in a cohort of type 1 diabetes mellitus patients over a 20-year follow-up.
Role of the lipoxygenase pathway in phenylephrine-induced vascular smooth muscle cell proliferation and migration.
The ALOXA5AP gene (rs38022789) is associated with diabetic nephropathy in Slovenian patients with type 2 diabetes mellitus.
The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese population.
Diabetes Mellitus, Type 1
12(S)-HETE impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose-induced vascular injury.
12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes.
Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15(null) Mice, Leading to Protection against Type 1 Diabetes Development.
Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes.
Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes.
Inhibition of 12/15-Lipoxygenase Protects Against ? Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes.
Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes.
Lipids and immunoinflammatory pathways of beta cell destruction.
Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.
RAGE and CYBA polymorphisms are associated with microalbuminuria and end-stage renal disease onset in a cohort of type 1 diabetes mellitus patients over a 20-year follow-up.
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.
The Four-Way Stop Sign: Viruses, 12-Lipoxygenase, Islets, and Natural Killer Cells in Type 1 Diabetes Progression.
Diabetes Mellitus, Type 2
12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets.
5-Lipoxygenase (ALOX5): Genetic susceptibility to type 2 diabetes and vitamin D effects on monocytes.
Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice.
Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet.
Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes.
Decreased activity of arachidonate 12-lipoxygenase in platelets of Japanese patients with non-insulin-dependent diabetes mellitus.
Evaluation of the oxidative stress-related genes ALOX5, ALOX5AP, GPX1, GPX3 and MPO for contribution to the risk of type 2 diabetes mellitus in the Han Chinese population.
Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes.
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease.
Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies.
Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications.
The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese population.
The role of 12-lipoxygenase in pancreatic -cells (Review).
Diabetic Angiopathies
Inhibition of 12/15-Lipoxygenase Reduces Renal Inflammation and Injury in Streptozotocin-Induced Diabetic Mice.
Lipid inflammatory mediators in diabetic vascular disease.
Diabetic Cardiomyopathies
Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.
Diabetic Nephropathies
12-Lipoxygenase as a key pharmacological target in the pathogenesis of diabetic nephropathy.
12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance.
12-lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy.
12/15-lipoxygenase inhibitors in diabetic nephropathy in the rat.
7-Ketocholesterol induces ROS-mediated mRNA expression of 12-lipoxygenase, cyclooxygenase-2 and pro-inflammatory cytokines in human mesangial cells: Potential role in diabetic nephropathy.
Association of ALOX12 gene polymorphism with all-cause and cardiovascular mortality in diabetic nephropathy.
Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice.
Effect of angiotensin II type 1 receptor blocker on 12-lipoxygenase activity and slit diaphragm protein expression in type 2 diabetic rat glomeruli.
Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes.
Effects of pravastatin or 12/15 lipoxygenase pathway inhibitors on indices of diabetic nephropathy in an experimental model of diabetic renal disease.
Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy.
p16ink4a Expression Is Increased through 12-Lipoxygenase in High Glucose-Stimulated Glomerular Mesangial Cells and Type 2 Diabetic Glomeruli.
Products of 12/15-lipoxygenase upregulate the angiotensin II receptor.
Relationship between 12/15-lipoxygenase and COX-2 in mesangial cells: potential role in diabetic nephropathy.
Role of 12-lipoxygenase in decreasing P-cadherin and increasing angiotensin II type 1 receptor expression according to glomerular size in type 2 diabetic rats.
Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes.
Roles of 12-Lipoxygenase and Its Interaction with Angiotensin II on p21 and p27 Expression in Diabetic Nephropathy.
Diabetic Neuropathies
Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies.
Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies.
Diabetic Retinopathy
5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase.
Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization.
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids.
Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy.
Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis.
Dyslipidemias
Cyclocarya paliurus Leaves Tea Improves Dyslipidemia in Diabetic Mice: A Lipidomics-Based Network Pharmacology Study.
Embolic Stroke
Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes.
Encephalitis
12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis.
Encephalomyelitis
12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function.
Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPAR?/?: a potential therapeutic role for CNS autoimmune disease.
Encephalomyelitis, Autoimmune, Experimental
12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function.
Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase.
Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPAR?/?: a potential therapeutic role for CNS autoimmune disease.
Endocarditis
Monocyte responses in the context of q Fever: from a static polarized model to a kinetic model of activation.
Endometriosis
Absence of association between a functional polymorphism of ALOX15 gene and infertility in endometriosis.
Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models.
Endotoxemia
Hydroxyeicosatetraenoic acids are increased in bronchoalveolar lavage fluid of endotoxemic pigs.
Enterocolitis
Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.
Eosinophilia
Comparison of 5- and 15-lipoxygenase activities in blood and alveolar leukocyte preparations from normal subjects and patients with eosinophilia.
Comparison of arachidonic acid metabolism in nasal polyps and eosinophils.
Correlation of ALOX15 expression with eosinophilic or reflux esophagitis in a cohort of pediatric patients with esophageal eosinophilia.
Eosinophilic Esophagitis
ALOX15 Immunohistochemistry Aids in the Diagnosis of Eosinophilic Esophagitis on Pauci-Eosinophilic Biopsies in Children.
ALOX15 Immunohistochemistry Aids in the Diagnosis of Eosinophilic Esophagitis on Pauci-eosinophilic Biopsies in Children.
Expression microarray analysis identifies novel epithelial-derived protein markers in eosinophilic esophagitis.
Epilepsy
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy.
Erectile Dysfunction
Baicalein Alleviates Erectile Dysfunction Associated With Streptozotocin-Induced Type I Diabetes by Ameliorating Endothelial Nitric Oxide Synthase Dysfunction, Inhibiting Oxidative Stress and Fibrosis.
Erythema
The eicosanoid response to high dose UVR exposure of individuals prone and resistant to sunburn.
The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases.
Esophageal Neoplasms
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
12-lipoxygenase promotes tumor progress by TGF-?1-mediated epithelial to mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.
Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Esophagitis
Correlation of ALOX15 expression with eosinophilic or reflux esophagitis in a cohort of pediatric patients with esophageal eosinophilia.
Esophagitis, Peptic
Correlation of ALOX15 expression with eosinophilic or reflux esophagitis in a cohort of pediatric patients with esophageal eosinophilia.
Essential Hypertension
A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE.
Increased levels of 12(S)-HETE in patients with essential hypertension.
Fatty Liver
Fatty acids modulate the expression of pyruvate kinase and arachidonate-lipoxygenase through PPAR?/CYP2C45 pathway: a link to goose fatty liver.
Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis.
Fibrosarcoma
In vitro proliferation of fibrosarcoma cells depends on intact functions of lipoxygenases and cytochrome P-450-monooxygenase.
Gastroesophageal Reflux
Correlation of ALOX15 expression with eosinophilic or reflux esophagitis in a cohort of pediatric patients with esophageal eosinophilia.
Gastrointestinal Diseases
Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula.
Glioblastoma
Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population.
Glioma
12-Lipoxygenase overexpression in rodent NG108-15 cells enhances membrane excitability by inhibiting M-type K+ channels.
Glomerulonephritis
15-Lipoxygenase products as leukotriene antagonists: therapeutic potential in glomerulonephritis.
Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis.
Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis.
Leukotrienes and 15-lipoxygenase products in glomerulonephritis.
Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction.
Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis.
Glucose Intolerance
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Granuloma
Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni.
Granulomatous Disease, Chronic
Activation of NADPH oxidase required for macrophage-mediated oxidation of low-density lipoprotein.
Heart Arrest
Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia.
Heart Failure
Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.
Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure.
Hypoxic cardiac fibroblasts from failing human hearts decrease cardiomyocyte beating frequency in an ALOX15 dependent manner.
Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways.
Inhibition of 12/15-LO ameliorates CVB3-induced myocarditis by activating Nrf2.
Herpes Zoster
Characterization and application of Raman labels for confocal Raman microspectroscopic detection of cellular proteins in single cells.
Evidence that a leukocyte type of 12-lipoxygenase is expressed and regulated by angiotensin II in human adrenal glomerulosa cells.
Hodgkin Disease
Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells.
hydroperoxy icosatetraenoate dehydratase deficiency
Diminished protein-bound ?-hydroxylated ceramides in the skin of patients with ichthyosis with 12R-lipoxygenase (LOX) or eLOX-3 deficiency.
Hyperalgesia
Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat.
Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies.
Effect of high-fat diet on peripheral neuropathy in C57BL/6 mice.
Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord.
Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.
Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors.
Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia.
Hypercholesterolemia
Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids.
Inducible Endothelium-derived Hyperpolarizing Factor: Role of the 15-Lipoxygenase-EDHF Pathway.
Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS.
Relationship of vascular 15-lipoxygenase induction to atherosclerotic plaque formation in rabbits.
Systemic activation of 15-lipoxygenase in heart, lung, and vascular tissues by hypercholesterolemia: relationship to lipoprotein oxidation and atherogenesis.
Hypereosinophilic Syndrome
Arachidonic acid metabolism in normal and hypereosinophilic syndrome human eosinophils: generation of leukotrienes B4, C4, D4 and 15-lipoxygenase products.
Hyperglycemia
12-Lipoxygenase products increase monocyte:endothelial interactions.
Decreased activity of arachidonate 12-lipoxygenase in platelets of Japanese patients with non-insulin-dependent diabetes mellitus.
Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice.
High-fat diet induced neuropathy of pre-diabetes and obesity: effects of 'healthy' diet and aldose reductase inhibition.
Lipids and immunoinflammatory pathways of beta cell destruction.
Hyperlipidemias
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Nutrigenetic Disruption of Inflammation-Resolution Homeostasis and Atherogenesis.
Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model.
Hyperlipoproteinemia Type II
Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia.
Hypertension
12-Lipoxygenase metabolism in mouse distal convoluted tubule cells.
15-Lipoxygenase Promotes Chronic Hypoxia-Induced Phenotype Changes of PASMCs via Positive Feedback-Loop of BMP4.
15-Lipoxygenase Promotes Chronic Hypoxia-Induced Pulmonary Artery Inflammation via Positive Interaction With Nuclear Factor-?B.
A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE.
Association of genetic variants with myocardial infarction in individuals with or without hypertension or diabetes mellitus.
Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation.
Comparison of 12-lipoxygenase expression in vascular smooth muscle cells from old normotensive Wistar-Kyoto rats with spontaneously hypertensive rats.
Deactivation of 12(S)-HETE through (?-1)-hydroxylation and ?-oxidation in alternatively activated macrophages.
Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.
Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice.
Elk-1-mediated 15-Lipoxygenase Expression is Required for Hypoxia-induced Pulmonary Vascular Adventitial Fibroblast Dynamics.
Heme oxygenase-1 induces 15-lipoxygenase expression during hypoxia-induced pulmonary hypertension.
Increase in 12-lipoxygenase activity in platelets of spontaneously hypertensive rats.
Increased levels of 12(S)-HETE in patients with essential hypertension.
Inflammation and immune regulation by 12/15-lipoxygenases.
Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways.
Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension.
Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension.
Reciprocal regulation of HIF-1? and 15-LO/15-HETE promotes anti-apoptosis process in pulmonary artery smooth muscle cells during hypoxia.
Reduced growth factor responses in vascular smooth muscle cells derived from 12/15-lipoxygenase-deficient mice.
Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor-kappa B (NF-kappa B).
ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid (15-HETE) mediated the pulmonary vascular remodeling induced by hypoxia in rat.
Role of macrophage PPAR? in experimental hypertension.
Role of the lipoxygenase pathway in phenylephrine-induced vascular smooth muscle cell proliferation and migration.
The key role of transforming growth factor-beta receptor I and 15-lipoxygenase in hypoxia-induced proliferation of pulmonary artery smooth muscle cells.
The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells.
[Lipoxygenase inhibition and protection of cardiovascular system]
Hypertension, Pulmonary
15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension.
Heme oxygenase-1 induces 15-lipoxygenase expression during hypoxia-induced pulmonary hypertension.
Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension.
NFATc3 pathway participates in the process that 15-LO/15-HETE protects pulmonary artery smooth muscle cells against apoptosis during hypoxia.
Placenta growth factor mediates angiogenesis in hypoxic pulmonary hypertension.
Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition.
Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension.
Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation.
Hypotension
15-Lipoxygenase metabolites contribute to age-related reduction in acetylcholine-induced hypotension in rabbits.
Ichthyosiform Erythroderma, Congenital
Congenital ichthyosiform erythroderma with a novel variant in ABCA12 in a Chinese patient.
Different TGM1 mutation spectra in Italian and Portuguese patients with autosomal recessive congenital ichthyosis: evidence of founder effects in Portugal.
Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.
Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.
Partially disturbed lamellar granule secretion in mild congenital ichthyosiform erythroderma with ALOX12B mutations.
Ichthyosis
12R-lipoxygenase deficiency disrupts epidermal barrier function.
A novel deletion mutation in the ALOX12B gene in a Kurdish family with autosomal recessive congenital ichthyosis.
Aloxe3 Knockout Mice Reveal a Function of Epidermal Lipoxygenase-3 as Hepoxilin Synthase and Its Pivotal Role in Barrier Formation.
An update on molecular aspects of the non-syndromic ichthyoses.
Analysis of TGM1, ALOX12B, ALOXE3, NIPAL4 and CYP4F22 in autosomal recessive congenital ichthyosis from Galicia (NW Spain): evidence of founder effects.
Characterization of Epidermal Lipoxygenase Expression in Normal Human Skin and Tissue-Engineered Skin Substitutes.
Conditional Alox12b Knockout: Degradation of the Corneocyte Lipid Envelope in a Mouse Model of Autosomal Recessive Congenital Ichthyoses.
Development of an ichthyosiform phenotype in Alox12b-deficient mouse skin transplants.
Diminished protein-bound ?-hydroxylated ceramides in the skin of patients with ichthyosis with 12R-lipoxygenase (LOX) or eLOX-3 deficiency.
Genotype-phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis.
Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients.
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.
Identification of a novel PNPLA1 mutation in a Spanish family with autosomal recessive congenital ichthyosis.
Identification of Mutations in SDR9C7 in 6 Families with Autosomal Recessive Congenital Ichthyosis.
Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B.
Mutation in ALOX12B likely cause of POI and also ichthyosis in a large Iranian pedigree.
Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis.
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.
Nonsense mutation in the ALOX12B gene leads to autosomal recessive congenital ichthyosis in a Lebanese family.
Novel ALOX12B Mutation Identified in Parents following Single Nucleotide Polymorphism Microarray Testing of Banked DNA from a Fatal Case of Congenital Ichthyosis.
Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.
Partially disturbed lamellar granule secretion in mild congenital ichthyosiform erythroderma with ALOX12B mutations.
Pseudodominant inheritance of self-improving collodion ichthyosis with homozygous mutation in the ALOX12B gene.
Report of a Novel ALOX12B Mutation in Self-Improving Collodion Ichthyosis with an Overview of the Genetic Background of the Collodion Baby Phenotype.
The hepoxilin connection in the epidermis.
The role of lipoxygenases in epidermis.
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
Updated molecular genetics and pathogenesis of ichthiyoses.
Ichthyosis, Lamellar
A novel mutation in the 12(R)-lipoxygenase (ALOX12B) gene underlies nonbullous congenital ichthyosiform erythroderma.
Different TGM1 mutation spectra in Italian and Portuguese patients with autosomal recessive congenital ichthyosis: evidence of founder effects in Portugal.
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.
Lamellar Ichthyosis Due to ALOX12B Mutation.
Self-healing collodion membrane and mild nonbullous congenital ichthyosiform erythroderma due to 2 novel mutations in the ALOX12B gene.
Ileus
A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation.
Immune System Diseases
5-Lipoxygenase is a direct p53 target gene in humans.
Infarction, Middle Cerebral Artery
12/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke.
Baicalein and 12/15-lipoxygenase in the ischemic brain.
Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.
Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway.
Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models.
Neuroprotection of taurine through inhibition of 12/15 lipoxygenase pathway in cerebral ischemia of rats.
Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia.
Infections
ALOX12 In Human Toxoplasmosis.
Characterization of arachidonate 12-lipoxygenase found in the liver of mongrel dog and its immunohistochemical localization in neutrophils.
Cyclooxygenase-2 Generates the Endogenous Mutagen trans-4-Hydroxy-2-nonenal in Enterococcus faecalis-Infected Macrophages.
Cytosolic phospholipase A2? promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection.
Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils.
Enteroaggregative Escherichia coli promotes transepithelial migration of neutrophils through a conserved 12-lipoxygenase pathway.
Evaluation of the expression level of 12/15 lipoxygenase and the related inflammatory factors (CCL5, CCL3) in respiratory syncytial virus infection in mice model.
Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis.
Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers.
Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis.
Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation.
Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni.
On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells.
Peripheral blood leukocytes show differential expression of tumour progression-related genes in colorectal cancer patients who have a postoperative intra-abdominal infection: a prospective matched cohort study.
Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection.
Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection.
Systemic Disease during Streptococcus pneumoniae Acute Lung Infection Requires 12-Lipoxygenase-Dependent Inflammation.
The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases.
The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration.
Infertility
Absence of association between a functional polymorphism of ALOX15 gene and infertility in endometriosis.
Infertility, Male
Male subfertility induced by heterozygous expression of catalytically inactive glutathione peroxidase 4 is rescued in vivo by systemic inactivation of the Alox15 gene.
Mechanistic Insight into the Regulation of Lipoxygenase-Driven Lipid Peroxidation Events in Human Spermatozoa and Their Impact on Male Fertility.
Inflammatory Bowel Diseases
Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease.
Influenza, Human
Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection.
Insulin Resistance
12- and 15-lipoxygenases in adipose tissue inflammation.
12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance.
12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.
12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice.
12/15-Lipoxygenase Products Induce Inflammation and Impair Insulin Signaling in 3T3-L1 Adipocytes.
12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.
Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice.
Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes.
Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet.
ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Evidence for Activation of Inflammatory Lipoxygenase Pathways in Visceral Adipose Tissue of Obese Zucker Rats.
Identification of ALOX5 as a gene regulating adiposity and pancreatic function.
Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease.
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity.
Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase.
Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis.
Insulinoma
Hepoxilin A3 synthase.
The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A3 synthase activity.
Ischemic Attack, Transient
12- and 15-lipoxygenases in human carotid atherosclerotic lesions: Associations with cerebrovascular symptoms.
Ischemic Stroke
15-oxo-ETE-induced internal carotid artery constriction in hypoxic rats is mediated by potassium channels.
A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population.
Association of ALOX15 Gene Polymorphism with Ischemic Stroke in Northern Chinese Han Population.
Association of ALOX5, LTA4H and LTC4S gene polymorphisms with ischemic stroke risk in a cohort of Chinese in east China.
Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke.
Genetic Variations of Oxidative Stress Related Genes ALOX5, ALOX5AP and MPO Modulate Ischemic Stroke Susceptibility Through Main Effects and Epistatic Interactions in a Chinese Population.
Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children.
Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Lipoxygenase inhibitor ML351 dysregulated an innate inflammatory response leading to impaired cardiac repair in acute heart failure.
Stroke: 12/15-lipoxygenase inhibitor shows promise as a first-line therapy for ischaemic stroke.
Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
Keratitis
Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis.
Kidney Diseases
Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice.
Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes.
Prediabetic nephropathy as an early consequence of the high-calorie/high-fat diet: relation to oxidative stress.
Kidney Failure, Chronic
Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure.
Leukemia
12-Lipoxygenase from rat basophilic leukemia cells, an oxygenase with leukotriene A4-synthase activity.
12-Lipoxygenase from rat basophilic leukemia cells: separation from 5-lipoxygenase and temperature-dependent inactivation by hydroperoxy fatty acid.
12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes.
A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia.
ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia.
Calcium stimulation of a novel 12-lipoxygenase from rat basophilic leukemia (RBL-1) cells.
Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia.
Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease.
Improved purification of 12-lipoxygenase from rat basophilic leukemia cells and conditions for optimal enzyme activity.
Inhibition of adenylyl cyclases by 12(S)-hydroxyeicosatetraenoic acid.
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia.
LSK derived LSK- cells have a high apoptotic rate related to survival regulation of hematopoietic and leukemic stem cells.
Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase.
Tumor microenvironment determines drug efficacy in vitro - apoptotic and anti-inflammatory effects of 15-lipoxygenase metabolite, 13-HpOTrE.
Zinc and other divalent cations inhibit purified leukotriene A4 hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes.
[Apoptosis in P388 leukemia cells induced by specific inhibitors of 5- and 12-lipoxygenase and the product of cyclooxygenase, prostaglandin E2]
Leukemia, Erythroblastic, Acute
15-Lipoxygenase products affect protein phosphorylation in Friend erythroleukemia cells.
A novel form of platelet-type 12-lipoxygenase mRNA in human vascular smooth muscle cells.
Actions of lipoxins A4 and B4 on signal transduction events in Friend erythroleukemia cells.
Activity and protein distribution of 12-lipoxygenase in HEL cells: induction of membrane-association by phorbol ester TPA, modulation of activity by glutathione and 13-HPODE, and Ca(2+)-dependent translocation to membranes.
Characterization of human 12-lipoxygenase genes.
Cloning of the cDNA for human 12-lipoxygenase.
Evidence that a leukocyte type of 12-lipoxygenase is expressed and regulated by angiotensin II in human adrenal glomerulosa cells.
Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells.
Induction of cyclooxygenase and suppression of 12-lipoxygenase in human erythroleukemia cells upon phorbol ester-induced differentiation.
Molecular cloning and expression of human arachidonate 12-lipoxygenase.
Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.
Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system.
Relation between ABCB1 overexpression and COX2 and ALOX5 genes in human erythroleukemia cell lines.
Ribozyme-mediated suppression of platelet type 12 lipoxygenase in human erythroleukemia cells.
Suppression of platelet-type 12-lipoxygenase activity in human erythroleukemia cells by an RNA-cleaving DNAzyme.
The transcriptional regulation of human arachidonate 12-lipoxygenase gene by NF kappa B/Rel.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia.
Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia.
Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis.
Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34(+)CD38(-) stem and progenitor cells in chronic myeloid leukemia.
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia.
Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at diagnosis of chronic myeloid leukemia.
The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia.
Leukemia, Myeloid
[Relationship between Polymorphism in ALOX5, ALOX5AP and Susceptibility to Myeloid Leukemia].
Leukemia, Myeloid, Acute
Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia.
Leukomalacia, Periventricular
12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia.
Leukostasis
Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis.
Liver Cirrhosis
Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice.
Melatonin suppresses activation of hepatic stellate cells through ROR?-mediated inhibition of 5-lipoxygenase.
Liver Diseases
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase.
Protection from hepatic lipid accumulation and inflammation by genetic ablation of 5-lipoxygenase.
Lung Diseases
Interleukin-4 enhances 15-lipoxygenase activity and incorporation of 15(S)-HETE into cellular phospholipids in cultured pulmonary epithelial cells.
Substituted (E)-2-(2-benzylidenehydrazinyl)-4-methylthiazole-5-carboxylates as dual inhibitors of 15-lipoxygenase & carbonic anhydrase II: synthesis, biochemical evaluation and docking studies.
Lung Injury
12-Lipoxygenase is a Critical Mediator of Type II Pneumocyte Senescence, Macrophage Polarization and Pulmonary Fibrosis after Irradiation.
Altered expression of cyclooxygenase-2, 12-lipoxygenase, inducible nitric oxide synthase-2 and surfactant protein D in lungs of patients with pulmonary injury caused by sulfur mustard.
Collagenase-3 induction in rat lung fibroblasts requires the combined effects of tumor necrosis factor-alpha and 12-lipoxygenase metabolites: a model of macrophage-induced, fibroblast-driven extracellular matrix remodeling during inflammatory lung injury.
Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue.
Lung Neoplasms
Effects of ALOX5, IL6R and SFTPD gene polymorphisms on the risk of lung cancer: A case-control study in China.
Inhibition of arachidonate lipoxygenase12 targets lung cancer through inhibiting EMT and suppressing RhoA and NF-?B activity.
Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines.
The future of cyclooxygenase-2 inhibitors and other inhibitors of the eicosanoid signal pathway in the prevention and therapy of lung cancer.
Lymphatic Metastasis
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
[Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]
Lymphoma
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.
Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.
Transcriptional regulation of 15-lipoxygenase expression by promoter methylation.
Lymphoma, B-Cell
Autophagy as a Regulatory Component of Erythropoiesis.
Lymphoma, Mantle-Cell
Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.
Melanoma
12-lipoxygenase expression in human melanoma cell lines.
Autocrine motility factor induces differential 12-lipoxygenase expression and activity in high- and low-metastatic K1735 melanoma cell variants.
Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen species via 12-lipoxygenase.
Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.
Enhancement role of host 12/15-lipoxygenase in melanoma progression.
Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis.
Molecular identification, localization and function of platelet-type 12-lipoxygenase in human melanoma progression, under experimental and clinical conditions.
Melanoma, Amelanotic
Activation of microvascular endothelium by eicosanoid 12(S)-hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regulation of surface expression of alpha v beta 3 integrin: a posttranscriptional, protein kinase C- and cytoskeleton-dependent process.
Melanoma, Experimental
Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis.
Memory Disorders
Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.
Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, A? and tau neuropathology in the triple-transgenic mice.
Mesothelioma
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Metabolic Diseases
Minireview: 12-Lipoxygenase and Islet ?-Cell Dysfunction in Diabetes.
Metabolic Syndrome
Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome.
Increased 12/15-Lipoxygenase Enhances Cell Growth, Fibronectin Deposition, and Neointimal Formation in Response to Carotid Injury.
Migraine Disorders
Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula.
Mouth Neoplasms
Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors.
Multiple Sclerosis
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPAR?/?: a potential therapeutic role for CNS autoimmune disease.
The role of expression and activity of 15-Lipoxygenase isoforms and related cytokines in patients with Multiple Sclerosis and healthy controls.
Muscular Atrophy
Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy.
Myeloproliferative Disorders
Decreased messenger RNA of arachidonate 12-lipoxygenase in platelets of patients with myeloproliferative disorders.
Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease.
Qualitative platelet 12-lipoxygenase abnormality in a patient with essential thrombocythemia.
Reduced 12-lipoxygenase activity in platelets of patients with myeloproliferative disorders.
Myocardial Infarction
A functional Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene is not associated with myocardial infarction.
Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction.
Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways.
No association of two functional polymorphisms in human ALOX15 with myocardial infarction.
Protease-activated receptor 2 protects against myocardial ischemia-reperfusion injury through the lipoxygenase pathway and TRPV1 channels.
Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
Myocardial Reperfusion Injury
Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species.
Myocarditis
Inhibition of 12/15-LO ameliorates CVB3-induced myocarditis by activating Nrf2.
nad(p)h oxidase (h2o2-forming) deficiency
Novel effect of oxidized low-density lipoprotein: cellular ATP depletion via downregulation of glyceraldehyde-3-phosphate dehydrogenase.
Nasal Polyps
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
Arachidonic Acid 15-Lipoxygenase: Effects of Its Expression, Metabolites, and Genetic and Epigenetic Variations on Airway Inflammation.
Comparison of arachidonic acid metabolism in nasal polyps and eosinophils.
Expression of cyclooxygenase and lipoxygenase enzymes in nasal polyps of aspirin-sensitive and aspirin-tolerant patients.
Oxidative metabolism of N-phenyllinoleamide by human nasal polyps.
Neoplasm Metastasis
12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells.
12-lipoxygenase expression in human melanoma cell lines.
12-Lipoxygenase promotes epithelial-mesenchymal transition via the Wnt/?-catenin signaling pathway in gastric cancer cells.
12-Lipoxygenase promotes invasion and metastasis of human gastric cancer cells via epithelial-mesenchymal transition.
12-Lipoxygenase, 12(S)-HETE, and cancer metastasis.
12-lipoxygenases and 12(S)-HETE: role in cancer metastasis.
15-Lipoxygenases in cancer: A double-edged sword?
A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway.
Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.
Brachmann-Cornelia de Lange syndrome with a papilloma of the choroid plexus: analyses of molecular genetic characteristics of the patient and the tumor. A single-case study.
Convergence of eicosanoid and integrin biology: Role of Src in 12-LOX activation.
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.
Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer.
Exploring the chemopreventive properties and perspectives of baicalin and its aglycone baicalein in solid tumors.
Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis.
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential.
Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.
In vitro 12(S)-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi.
Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase.
Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo.
Inhibition of radiation-enhanced expression of integrin and metastatic potential in B16 melanoma cells by a lipoxygenase inhibitor.
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
Molecular identification, localization and function of platelet-type 12-lipoxygenase in human melanoma progression, under experimental and clinical conditions.
Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase.
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation.
Role of lipoxygenases in breast cancer.
Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells.
[Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]
Neoplasms
12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-?B pathway in ovarian cancer.
12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells.
12-lipoxygenase expression in human melanoma cell lines.
12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes.
12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway.
12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells.
12-Lipoxygenase isoenzymes in mouse skin tumor development.
12-Lipoxygenase promotes epithelial-mesenchymal transition via the Wnt/?-catenin signaling pathway in gastric cancer cells.
12-Lipoxygenase promotes invasion and metastasis of human gastric cancer cells via epithelial-mesenchymal transition.
12-lipoxygenase promotes tumor progress by TGF-?1-mediated epithelial to mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.
12-Lipoxygenase, 12(S)-HETE, and cancer metastasis.
12-Lipoxygenase: classification, possible therapeutic benefits from inhibition, and inhibitors.
12-lipoxygenases and 12(S)-HETE: role in cancer metastasis.
12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models.
12/15-Lipoxygenase Products Induce Inflammation and Impair Insulin Signaling in 3T3-L1 Adipocytes.
15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer.
15-Lipoxygenases in cancer: A double-edged sword?
5-Lipoxygenase is a direct p53 target gene in humans.
A Cell-based Assay for Screening Lipoxygenase Inhibitors.
A dual role of 12/15-lipoxygenase in LPS-induced acute renal inflammation and injury.
A lipoxygenase metabolite, 12-(S)-HETE, stimulates protein kinase C-mediated release of cathepsin B from malignant cells.
A novel hydroxamic acid compound, BMD188, demonstrates anti-prostate cancer effects by inducing apoptosis. I: In vitro studies.
Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity.
ALOX12 In Human Toxoplasmosis.
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.
ALOX12B promotes carcinogenesis in cervical cancer by regulating the PI3K/ERK1 signaling pathway.
ALOX15 as a suppressor of inflammation and cancer: Lost in the link.
Alox5 Blockade Eradicates JAK2V617F-Induced Polycythemia Vera in Mice.
Alterations in eicosanoid levels during U937 bcl-xL tumour growth suppression and recovery in NU/NU mice in vivo-Involvement of phospholipase A2.
An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.
Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene.
Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo.
Anti-proliferative and pro-apoptotic effects of lichen-derived compound protolichesterinic acid are not mediated by its lipoxygenase-inhibitory activity.
Anti-proliferative effects of lichen-derived lipoxygenase inhibitors on twelve human cancer cell lines of different tissue origin in vitro.
Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and depletion of GSH: role of 12-lipoxygenase in regulating tumor cell survival.
Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer.
Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.
Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival.
Arachidonate 5 lipoxygenase expression in papillary thyroid carcinoma promotes invasion via MMP-9 induction.
Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model.
Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme.
Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.
Brachmann-Cornelia de Lange syndrome with a papilloma of the choroid plexus: analyses of molecular genetic characteristics of the patient and the tumor. A single-case study.
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer.
Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes.
Characterization of an 8-lipoxygenase activity induced by the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin in vivo.
Collagenase-3 induction in rat lung fibroblasts requires the combined effects of tumor necrosis factor-alpha and 12-lipoxygenase metabolites: a model of macrophage-induced, fibroblast-driven extracellular matrix remodeling during inflammatory lung injury.
Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner.
Convergence of eicosanoid and integrin biology: Role of Src in 12-LOX activation.
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.
Cyclooxygenase, lipoxygenase and tumor angiogenesis.
Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer.
Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells.
Effect of catechol derivatives on cell growth and lipoxygenase activity.
Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice.
Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene.
EGF-receptor tyrosine kinase and 12-lipoxygenase activity regulate expression of 12-lipoxygenase in human tumor cells.
Eicosanoid activation of extracellular signal-regulated kinase1/2 in human epidermoid carcinoma cells.
Eicosanoid regulation of angiogenesis in human prostate carcinoma and its therapeutic implications.
Eicosanoid regulation of angiogenesis in tumors.
Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer.
Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma.
Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.
Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression.
Enhanced tumor cell adhesion to the subendothelial matrix resulting from 12(S)-HETE-induced endothelial cell retraction.
Evaluation of 12-lipoxygenase (12-LOX) and plasminogen activator inhibitor 1 (PAI-1) as prognostic markers in prostate cancer.
Expression microarray analysis identifies novel epithelial-derived protein markers in eosinophilic esophagitis.
Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis.
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential.
Ferroptosis-Related Genes in Lung Adenocarcinoma: Prognostic Signature and Immune, Drug Resistance, Mutation Analysis.
GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma.
Genetic Variants in COX2 and ALOX Genes and Breast Cancer Risk in White and Black Women.
Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.
Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes.
High expression of human 15-lipoxygenase induces NF-kappaB-mediated expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and T-cell adhesion on human endothelial cells.
Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals.
Human 5-, 12- and 15-lipoxygenase-1 coexist in kidney but show opposite trends and their balance changes in cancer.
Human platelet 12-lipoxygenase, new findings about its activity, membrane binding and low-resolution structure.
Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.
Identification of the key genes and pathways involved in the tumorigenesis and prognosis of kidney renal clear cell carcinoma.
In vitro 12(S)-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi.
Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase.
Inflammation and immune regulation by 12/15-lipoxygenases.
Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis.
Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo.
Inhibition of arachidonate lipoxygenase12 targets lung cancer through inhibiting EMT and suppressing RhoA and NF-?B activity.
Inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some Indian medicinal plants.
Inhibition of tumour growth by lipoxygenase inhibitors.
Integrative Genomic and Transcriptomic Analyses of Tumor Suppressor Genes and Their Role on Tumor Microenvironment and Immunity in Lung Squamous Cell Carcinoma.
Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer.
Intracellular distribution, activity, and Ca(2+)-dependent translocation of 12-lipoxygenase in Lewis lung tumor cells.
Involvement of the multiple tumor suppressor genes and 12-lipoxygenase in human prostate cancer. Therapeutic implications.
Knockout of ALOX12 protects against spinal cord injury-mediated nerve injury by inhibition of inflammation and apoptosis.
Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer.
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity.
Lipoxygenase in Human Tumor Cells.
Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12-lipoxygenase, 15-lipoxygenase and leukotriene receptor antagonists.
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Loss of heterozygosity of 17p13, with possible involvement of ACADVL and ALOX15B, in the pathogenesis of adrenocortical tumors.
Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma.
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells.
MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5.
Modulation of epidermal tumor development caused by targeted overexpression of epidermis-type 12S-lipoxygenase.
Molecular identification, localization and function of platelet-type 12-lipoxygenase in human melanoma progression, under experimental and clinical conditions.
Multiple use of a signal transduction pathway in tumor cell invasion.
Neuroprotection of taurine through inhibition of 12/15 lipoxygenase pathway in cerebral ischemia of rats.
Neutrophils support lung colonization of metastasis-initiating breast cancer cells.
Non-synonymous polymorphism (Gln261Arg) of 12-lipoxygenase in colorectal and thyroid cancers.
Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.
Overexpression of leukocyte-type 12-lipoxygenase promotes W256 tumor cell survival by enhancing alphavbeta5 expression.
Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer.
Overexpression of platelet-type 12-lipoxygenase promotes tumor cell survival by enhancing alpha(v)beta(3) and alpha(v)beta(5) integrin expression.
Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.
Platelet-12 lipoxygenase targeting via a newly synthesized curcumin derivative radiolabeled with technetium-99m.
Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency.
Platelet-type 12-lipoxygenase activates NF-kappaB in prostate cancer cells.
Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.
Platelets and cancer metastasis: a causal relationship?
Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase.
Polyunsaturated Fatty Acid Diet and Upregulation of Lipoxin A4 Reduce the Inflammatory Response of Preeclampsia.
Predominant synthesis of 5-hydroxyeicosatetraenoic acid by a cloned mastocytoma P-815 line, 2-E-6 cells.
RAD001 targeted HUVECs reverses 12-lipoxygenase-induced angiogenesis in oesophageal squamous cell carcinoma.
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells.
Requirement for epidermal growth factor receptor tyrosine kinase and for 12-lipoxygenase activity in the expression of 12-lipoxygenase in human epidermoid carcinoma cells.
Ribozyme-mediated suppression of platelet type 12 lipoxygenase in human erythroleukemia cells.
Role of 'platelet-type' 12-lipoxygenase in skin carcinogenesis.
Role of 12-lipoxygenase and protein kinase C in modulating the activation state of the integrin alpha IIb beta 3 on human tumor cells.
Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation.
Role of eicosanoids in prostate cancer progression.
Role of lipoxygenases in breast cancer.
Search of factors that intermediate cytokine-induced group IIA phospholipase A2 expression through the cytosolic phospholipase A2- and 12/15-lipoxygenase-dependent pathway.
Specific overexpression of 15-lipoxygenase in endothelial cells promotes cancer cell death in an in vivo Lewis lung carcinoma mouse model.
Suppression of platelet-type 12-lipoxygenase activity in human erythroleukemia cells by an RNA-cleaving DNAzyme.
Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells.
Targeting Lipid Peroxidation for Cancer Treatment.
The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia.
The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases.
The concentration of 12-lipoxygenase in platelet rich plasma as an indication of cancer of the prostate.
The future of cyclooxygenase-2 inhibitors and other inhibitors of the eicosanoid signal pathway in the prevention and therapy of lung cancer.
The importance of 15-lipoxygenase inhibitors in cancer treatment.
The modulatory properties of Si Jun Zi Tang enhancing anticancer of gefitinib by an integrating approach.
The polymorphism (Gln261Arg) of 12-lipoxygenase and cancer risk: a meta-analysis.
The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages.
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
Thrombin causes pseudopod detachment via a pathway involving cytosolic phospholipase A2 and 12/15-lipoxygenase products.
Transcriptional regulation of 15-lipoxygenase expression by promoter methylation.
Transient overexpression of human 15-lipoxygenase in aortic endothelial cells enhances tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression.
Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction.
Tumor microenvironment determines drug efficacy in vitro - apoptotic and anti-inflammatory effects of 15-lipoxygenase metabolite, 13-HpOTrE.
Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells.
Valsartan protects pancreatic islets and adipose tissue from the inflammatory and metabolic consequences of a high-fat diet in mice.
Vascular endothelial growth factor production in human prostate cancer cells is stimulated by overexpression of platelet 12-lipoxygenase.
Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation.
[Selective 12-lipoxygenase inhibition potentiates the effect of radiation on human prostate cancer cells in vitro and in vivo].
Nephritis
Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis.
Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis.
Inverse temporal changes of lipoxin A(4) and leukotrienes in children with Henoch-Schönlein purpura.
NZB/NZW F1 mouse nephritis and immune response are not changed by treatment with a 15-lipoxygenase derivative.
Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis.
Nervous System Diseases
12/15 lipoxygenase: A crucial enzyme in diverse types of cell death.
Neuroblastoma
12-Lipoxygenase overexpression in rodent NG108-15 cells enhances membrane excitability by inhibiting M-type K+ channels.
Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates.
Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells.
GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma.
Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy.
Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma.
Molecular mechanisms of fenretinide-induced apoptosis of neuroblastoma cells.
Omega-3 fatty acid supplementation delays the progression of neuroblastoma in vivo.
The NF-kappaB pathway mediates fenretinide-induced apoptosis in SH-SY5Y neuroblastoma cells.
The role of gangliosides in fenretinide-induced apoptosis of neuroblastoma.
Neurodegenerative Diseases
12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.
Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes.
Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells.
Inhibition of 12/15 LOX ameliorates cognitive and cholinergic dysfunction in mouse model of hypobaric hypoxia via. attenuation of oxidative/nitrosative stress.
Novel lipoxygenase inhibitors as neuroprotective reagents.
Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation.
The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases.
Non-alcoholic Fatty Liver Disease
Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice.
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase.
Obesity
12- and 15-lipoxygenases in adipose tissue inflammation.
12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.
12/15-Lipoxygenase Products Induce Inflammation and Impair Insulin Signaling in 3T3-L1 Adipocytes.
12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.
A high-fat diet induces bone loss in mice lacking the Alox5 gene.
Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes.
ALOX12 polymorphisms are associated with fat mass but not peak bone mineral density in Chinese nuclear families.
ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.
Evidence for Activation of Inflammatory Lipoxygenase Pathways in Visceral Adipose Tissue of Obese Zucker Rats.
Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma: A Randomized Trial.
Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease.
Prediabetic nephropathy as an early consequence of the high-calorie/high-fat diet: relation to oxidative stress.
Proliferation and differentiation of adipose tissue in prolonged lean and obese critically ill patients.
Optic Nerve Injuries
Neuroprotectin D1 inhibits retinal ganglion cell death following axotomy.
Osteoarthritis
Deletion of 12/15-lipoxygenase accelerates the development of aging-associated and instability-induced osteoarthritis.
Osteoporosis
ALOX12 gene polymorphisms and serum selenium status in elderly osteoporotic patients.
Genetic epidemiology of osteoporosis: past, present, and future.
Inflammation and immune regulation by 12/15-lipoxygenases.
Polymorphisms in the ALOX12 gene and osteoporosis.
Regulation of bone mass in mice by the lipoxygenase gene Alox15.
The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation.
Understanding our drugs and our diseases.
Osteoporosis, Postmenopausal
Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G/A) with bone mineral density.
Osteosarcoma
Cloning and expression of human leukocyte 5-lipoxygenase.
Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related.
Ovarian Neoplasms
Ovarian Cancer Risk Associated with Inherited Inflammation-Related Variants.
Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival.
Pancreatic Neoplasms
12-lipoxygenase metabolite 12(S)-HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation.
Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer.
Cyclooxygenases and lipoxygenases as potential targets for treatment of pancreatic cancer.
Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells.
Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells.
Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway.
Papilloma
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.
Parkinson Disease
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
Pemphigoid, Bullous
12/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation.
Perinatal Death
The role of lipoxygenases in epidermis.
Periodontal Diseases
Effect of Alox-15 Polymorphism on GCF Levels of Lipoxin-A4 in Chronic Periodontitis: A Preliminary Study.
Periodontitis
Expression profile of lipoxygenases in gingival tissues of human periodontitis.
Impaired polymorphonuclear leukocyte 15-lipoxygenase activity in juvenile and rapidly progressive periodontitis.
Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators.
Peripheral Nervous System Diseases
12/15-Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy.
Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy.
Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes.
Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies.
Peritonitis
Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice.
Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis.
Pituitary Neoplasms
Inhibition of adenylyl cyclases by 12(S)-hydroxyeicosatetraenoic acid.
Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas.
Pleurisy
In vivo anti-allergic and anti-inflammatory effects of drugs that inhibit lipoxygenase activity in vitro.
Pneumonia
12/15-Lipoxygenase Regulates IL-33-Induced Eosinophilic Airway Inflammation in Mice.
Cytosolic phospholipase A2? promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection.
Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury.
Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).
Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
Specialized pro-resolving lipid mediators regulate ozone-induced pulmonary and systemic inflammation.
Systemic Disease during Streptococcus pneumoniae Acute Lung Infection Requires 12-Lipoxygenase-Dependent Inflammation.
Polycystic Kidney, Autosomal Dominant
Bioactive lipid mediators in polycystic kidney disease.
Polycythemia Vera
Alox5 Blockade Eradicates JAK2V617F-Induced Polycythemia Vera in Mice.
Pre-Eclampsia
Preeclampsia activates 15-lipoxygenase and its metabolite 15-hydroxyeicosatetraenoic acid enhances constriction in umbilical arteries.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Identification of genetic variants associated with skeletal muscle function deficit in childhood acute lymphoblastic leukemia survivors.
Prediabetic State
Prediabetic nephropathy as an early consequence of the high-calorie/high-fat diet: relation to oxidative stress.
Prostatic Hyperplasia
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Prostatic Intraepithelial Neoplasia
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Prostatic Neoplasms
12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha.
12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells.
15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival.
15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids.
Apoptosis induction by a novel anti-prostate cancer compound, BMD188 (a fatty acid-containing hydroxamic acid), requires the mitochondrial respiratory chain.
Arachidonate 12-lipoxygenase may serve as a potential marker and therapeutic target for prostate cancer stem cells.
Associations between arachidonic acid metabolism gene polymorphisms and prostate cancer risk.
Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner.
Eicosanoid regulation of angiogenesis in human prostate carcinoma and its therapeutic implications.
Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer.
Evaluation of 12-lipoxygenase (12-LOX) and plasminogen activator inhibitor 1 (PAI-1) as prognostic markers in prostate cancer.
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential.
Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase.
Involvement of the multiple tumor suppressor genes and 12-lipoxygenase in human prostate cancer. Therapeutic implications.
Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
Overexpression of platelet-type 12-lipoxygenase promotes tumor cell survival by enhancing alpha(v)beta(3) and alpha(v)beta(5) integrin expression.
Platelet-type 12- lipoxygenase induces MMP9 expression and cellular invasion via activation of PI3K/AKT/NF-?B.
Platelet-type 12-lipoxygenase activates NF-kappaB in prostate cancer cells.
Prostate Cancer - Old Problems and New Approaches. (Part II. Diagnostic and Prognostic Markers, Pathology and Biological Aspects).
Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma.
Radiosensitivity of human prostate cancer cells can be modulated by inhibition of 12-lipoxygenase.
Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase.
Role of eicosanoids in prostate cancer progression.
Stylosin and some of its synthetic derivatives induce apoptosis in prostate cancer cells as 15-lipoxygenase enzyme inhibitors.
Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells.
The concentration of 12-lipoxygenase in platelet rich plasma as an indication of cancer of the prostate.
Vascular endothelial growth factor production in human prostate cancer cells is stimulated by overexpression of platelet 12-lipoxygenase.
Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation.
[Leukotriene-lipoxygenase pathway and drug discovery]
[Selective 12-lipoxygenase inhibition potentiates the effect of radiation on human prostate cancer cells in vitro and in vivo].
Proteinuria
Inhibition of 12/15-Lipoxygenase Reduces Renal Inflammation and Injury in Streptozotocin-Induced Diabetic Mice.
Inverse temporal changes of lipoxin A(4) and leukotrienes in children with Henoch-Schönlein purpura.
Role of 12-lipoxygenase in decreasing P-cadherin and increasing angiotensin II type 1 receptor expression according to glomerular size in type 2 diabetic rats.
Pruritus
TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase.
Psoriasis
Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis.
In vitro 12(S)-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi.
Inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some Indian medicinal plants.
Insulin-like growth factor-II regulates the 12-lipoxygenase gene expression and promotes cell proliferation in human keratinocytes via the extracellular regulatory kinase and phosphatidylinositol 3-kinase pathways.
Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-HETE.
Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12-lipoxygenase, 15-lipoxygenase and leukotriene receptor antagonists.
Lipoxygenase-catalyzed formation of R-configuration hydroperoxides.
Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.
Selective decrease of 15-hydroxyeicosatetraenoic acid (15-HETE) formation in uninvolved psoriatic dermis.
Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice.
Pulmonary Arterial Hypertension
15-Lipoxygenase Promotes Chronic Hypoxia-Induced Phenotype Changes of PASMCs via Positive Feedback-Loop of BMP4.
15-Lipoxygenase Promotes Chronic Hypoxia-Induced Pulmonary Artery Inflammation via Positive Interaction With Nuclear Factor-?B.
Heme oxygenase-1 induces 15-lipoxygenase expression during hypoxia-induced pulmonary hypertension.
Reciprocal regulation of HIF-1? and 15-LO/15-HETE promotes anti-apoptosis process in pulmonary artery smooth muscle cells during hypoxia.
ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid (15-HETE) mediated the pulmonary vascular remodeling induced by hypoxia in rat.
The key role of transforming growth factor-beta receptor I and 15-lipoxygenase in hypoxia-induced proliferation of pulmonary artery smooth muscle cells.
The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells.
Pulmonary Disease, Chronic Obstructive
Arachidonic Acid 15-Lipoxygenase: Effects of Its Expression, Metabolites, and Genetic and Epigenetic Variations on Airway Inflammation.
Development and Clinical Validation of a Novel 4-Gene Prognostic Signature Predicting Survival in Colorectal Cancer.
Expression of 15-lipoxygenase and evidence for apoptosis in the lungs from patients with COPD
Substituted (E)-2-(2-benzylidenehydrazinyl)-4-methylthiazole-5-carboxylates as dual inhibitors of 15-lipoxygenase & carbonic anhydrase II: synthesis, biochemical evaluation and docking studies.
The Perspective of Diagnostic and Prognostic Values of Lipoxygenases mRNA Expression in Colon Adenocarcinoma.
Pulmonary Fibrosis
12-Lipoxygenase is a Critical Mediator of Type II Pneumocyte Senescence, Macrophage Polarization and Pulmonary Fibrosis after Irradiation.
Q Fever
Monocyte responses in the context of q Fever: from a static polarized model to a kinetic model of activation.
Rectal Neoplasms
Genetic variation in prostaglandin synthesis and related pathways, NSAID use and colorectal cancer risk in the Colon Cancer Family Registry.
Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.
Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer.
PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer.
The polymorphism (Gln261Arg) of 12-lipoxygenase and cancer risk: a meta-analysis.
Reperfusion Injury
Activation of PPAR? by 12/15-lipoxygenase during cerebral ischemia-reperfusion injury.
Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species.
Respiratory Syncytial Virus Infections
Evaluation of the expression level of 12/15 lipoxygenase and the related inflammatory factors (CCL5, CCL3) in respiratory syncytial virus infection in mice model.
Retinal Neovascularization
Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization.
Rett Syndrome
13-HODE, 9-HODE and ALOX15 as potential players in Rett syndrome OxInflammation.
Rhinitis
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Rhinitis, Allergic
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
Schistosomiasis
Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni.
Seizures
Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis.
Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy.
Sepsis
Constructing a 10-core genes panel for diagnosis of pediatric sepsis.
Dual role of lipoxin A4 in pneumosepsis pathogenesis.
Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database.
Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection.
Skin Diseases
Control of somatic tissue differentiation by the long non-coding RNA TINCR.
Epidermal fatty acid oxygenases are activated in non-psoriatic dermatoses.
Lipoxygenase-catalyzed formation of R-configuration hydroperoxides.
Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.
Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice.
ZNF750 Is Expressed in Differentiated Keratinocytes and Regulates Epidermal Late Differentiation Genes.
Squamous Cell Carcinoma of Head and Neck
Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma.
Starvation
12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization.
Stomach Neoplasms
12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway.
12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells.
12-Lipoxygenase promotes epithelial-mesenchymal transition via the Wnt/?-catenin signaling pathway in gastric cancer cells.
12-Lipoxygenase promotes invasion and metastasis of human gastric cancer cells via epithelial-mesenchymal transition.
15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer.
ALOX5-5-HETE promotes gastric cancer growth and alleviates chemotherapy toxicity via MEK/ERK activation.
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer.
Stroke
12/15 Lipoxygenase as a Therapeutic Target in Brain Disorders.
12/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke.
12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress.
Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index.
Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke.
Effects of ML351 and tissue plasminogen activator combination therapy in a rat model of focal embolic stroke.
Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.
Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy.
Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia.
Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models.
Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke.
Key role of 15-LO/15-HETE in angiogenesis and functional recovery in later stages of post-stroke mice.
Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size.
Mice deficient in L-12/15 lipoxygenase show increased vulnerability to 3-nitropropionic acid neurotoxicity.
Neuroprotective properties of the natural vitamin E alpha-tocotrienol.
Novel lipoxygenase inhibitors as neuroprotective reagents.
Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation.
Potent and Selective Inhibitors of Human Reticulocyte 12/15- Lipoxygenase as Anti-Stroke Therapies.
Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.
Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPAR? and 5-LO-dependent pathways.
STAT-dependent upregulation of 12/15-lipoxygenase contributes to neuronal injury after stroke.
Stroke: 12/15-lipoxygenase inhibitor shows promise as a first-line therapy for ischaemic stroke.
The potential of 12/15-lipoxygenase inhibitors in stroke therapy.
Subarachnoid Hemorrhage
Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Tauopathies
Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.
Testicular Neoplasms
Relationship between lipoxygenase and human testicular cancer.
Thrombocythemia, Essential
Qualitative platelet 12-lipoxygenase abnormality in a patient with essential thrombocythemia.
Thrombocytopenia
Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus.
Role of molecular mimicry to HIV-1 peptides in HIV-1-related immunologic thrombocytopenia.
Thromboembolism
Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets.
Thrombosis
12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor.
12-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-?-Linolenic Acid, Inhibits Thrombosis via G?s Signaling in Platelets.
12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.
15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension.
Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generation.
DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway.
Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.
First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.
Lipid Receptor GPR31 (G-Protein-Coupled Receptor 31) Regulates Platelet Reactivity and Thrombosis Without Affecting Hemostasis.
Platelet 12-LOX is essential for Fc?RIIa-mediated platelet activation.
Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors.
Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice.
Targeting 12-Lipoxygenase As a Potential Novel Antiplatelet Therapy.
The Arachidonate 15-Lipoxygenase Enzyme Product 15-HETE Is Present in Heart Tissue from Patients with Ischemic Heart Disease and Enhances Clot Formation.
Thyroid Neoplasms
Non-synonymous polymorphism (Gln261Arg) of 12-lipoxygenase in colorectal and thyroid cancers.
Toxoplasmosis
12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis.
ALOX12 In Human Toxoplasmosis.
Toxoplasmosis, Congenital
ALOX12 In Human Toxoplasmosis.
Tuberculosis
ALOX5 Is Associated with Tuberculosis in a Subset of the Pediatric Population of North China.
Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis.
Tuberculosis, Pulmonary
ALOX5 variants associated with susceptibility to human pulmonary tuberculosis.
Urinary Bladder Neoplasms
Antitumor effects of lipoxygenase inhibitors on murine bladder cancer cell line (MBT-2).
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Urticaria
Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema.
Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirin-intolerant asthma: differing contributions of ALOX5 polymorphism in Korean population.
Uterine Cervical Neoplasms
ALOX12B promotes carcinogenesis in cervical cancer by regulating the PI3K/ERK1 signaling pathway.
Itraconazole Increases Resolvin E3 Concentration and 12/15-lipoxygenase Inhibitor Attenuates Itraconazole Cytotoxicity in Cervical Cancer Cells.
Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma.
Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models.
Vascular Diseases
12-Lipoxygenase and vascular disease.
15-Lipoxygenase and its inhibition: a novel therapeutic target for vascular disease.
A leukocyte type of 12-lipoxygenase is expressed in human vascular and mononuclear cells. Evidence for upregulation by angiotensin II.
Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation.
Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice.
Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells.
Role of the lipoxygenase pathway in phenylephrine-induced vascular smooth muscle cell proliferation and migration.
TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects.
The effects of leukocyte-type 12/15-lipoxygenase on Id3-mediated vascular smooth muscle cell growth.
Vascular System Injuries
Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia.
Lipoxygenase: An Emerging Target for Stroke Therapy.
Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia.
Vertigo
Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula.
Virus Diseases
Evaluation of the expression level of 12/15 lipoxygenase and the related inflammatory factors (CCL5, CCL3) in respiratory syncytial virus infection in mice model.
Original research article Parainfluenza virus infection enhances NSAIDs-induced inhibition of PGE2 generation and COX-2 expression in human airway epithelial cells.
Vitamin E Deficiency
The effect of dietary vitamin E and beta-carotene on oxidation processes in the rat testis.
Vitiligo
Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes.
Whooping Cough
Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic acid: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins.