Reference on EC 1.13.11.34 - arachidonate 5-lipoxygenase
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DeWolf, W.E.
Enzymatic studies on purified 5-lipoxygenase
Lipoxygenases and Their Products (Crooke, S. T. ed. ) Academic Press
105-135
1991
Cavia porcellus, Homo sapiens, Rattus norvegicus, Sus scrofa
-
Denis, D.; Falgueyret, J.P.; Riendeau, D.; Abramovitz, M.
Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors
J. Biol. Chem.
266
5072-5079
1991
Homo sapiens
Reddanna, P.; Whelan, J.; Maddipati, K.R.; Reddy, C.C.
Purification of arachidonate 5-lipoxygenase from potato tubers
Methods Enzymol.
187
268-277
1990
Solanum tuberosum
Shimizu, T.; Honda, Z.I.; Miki, I.; Seyama, Y.; Izumi, T.; Radmark, O.; Samuelsson, B.
Potato arachidonate 5-lipoxygenase: purification, characterization, and preparation of 5(S)-hydroperoxyeicosatetraenoic acid
Methods Enzymol.
187
296-306
1990
Solanum tuberosum
Rouzer, C.A.; Samuelsson, B.
Leukocyte arachidonate 5-lipoxygenase: isolation and characterization
Methods Enzymol.
187
312-319
1990
Homo sapiens
Ueda, N.; Yamamoto, S.
Immunoaffinity purification of arachidonate 5-lipoxygenase from porcine leukocytes
Methods Enzymol.
187
338-343
1990
Sus scrofa
Riendeau, D.; Falgueyret, J.P.; Nathaniel, D.J.; Rokach, J.; Ueda, N.; Yamamoto, S.
Sensitivity of immunoaffinity-purified porcine 5-lipoxygenase to inhibitors and activating lipid hydroperoxides
Biochem. Pharmacol.
38
2313-2321
1989
Sus scrofa
McMillan, R.M.; Masters, D.J.; Vickers, V.C.; Dicken, M.P.; Jacobs, V.N.
Metabolism of unsaturated fatty acids by RBL-1 5-lipoxygenase: influence of substrate solubility and product inactivation
Biochim. Biophys. Acta
1005
170-176
1989
Rattus norvegicus
Denis, D.; Choo, L.Y.; Riendeau, D.
Activation of 5-lipoxygenase by guanosine 5-O-(3-thiotriphosphate) and other nucleoside phosphorothioates: redox properties of thionucleotide analogs
Arch. Biochem. Biophys.
273
592-596
1989
Rattus norvegicus
Reddanna, P.; Whelan, J.; Reddy, P.S.; Reddy, C.C
Isolation and characterization of 5-lipoxygenase from tulip bulbs
Biochem. Biophys. Res. Commun.
157
1348-1351
1988
Tulipa hybrid cultivar
Cashman, J.R.; Lambert, C.; Sigal, E.
Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids
Biochem. Biophys. Res. Commun.
155
38-44
1988
Homo sapiens
Rouzer, C.A.; Rands, E.; Kargman, S.; Jones, R.E.; Register, R.B.; Dixon, R.A.F.
Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells
J. Biol. Chem.
263
10135-10140
1988
Homo sapiens
Haurand, M.; Flohe, L.
Kinetic studies on arachidonate 5-lipoxygenase from rat basophilic leukemia cells
Biol. Chem. Hoppe-Seyler
369
133-142
1988
Rattus norvegicus
Masters, D.J.; Jacobs, V.N.; Carr, V.J.; McMillan, R.M.
Kinetics of 5-lipoxygenase: influence of substrate solubility and product inactivation
Biochem. Soc. Trans.
16
38-39
1988
Rattus norvegicus
-
Soberman, R.J.
5- and 15(omega-6)-lipoxygenases from human polymorphonuclear leukocytes
Methods Enzymol.
163
344-349
1988
Homo sapiens
Ueda, N.; Yamamoto, S.
The 6R-oxygenase activity of arachidonate 5-lipoxygenase purified from porcine leukocytes
J. Biol. Chem.
263
1937-1941
1988
Sus scrofa
Skoog, M.T.; Nichols, J.S.; Wiseman, J.S.
5-Lipoxygenase from rat PMN lysate
Prostaglandins
31
561-576
1986
Rattus norvegicus
Mulliez, E.; Leblanc, J.P.; Girerd, J.J.; Rigaud, M.; Chottard, J.C.
5-Lipoxygenase from potato tubers. Improved purification and physicochemical characteristics
Biochim. Biophys. Acta
916
13-23
1987
Solanum tuberosum
-
Wiseman, J.S.; Skoog, M.T.; Nichols, J.S.; Harrison, B.L.
Kinetics of leukotriene A4 synthesis by 5-lipoxygenase from rat polymorphonuclear leukocytes
Biochemistry
26
5684-5689
1987
Rattus norvegicus
Ueda, N.; Kaneko, S.; Yoshimoto, T.; Yamamoto.S.
Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids
J. Biol. Chem.
261
7982-7988
1986
Sus scrofa
Aharony, D.; Stein.R.L.
Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase
J. Biol. Chem.
261
11512-11519
1986
Cavia porcellus
Shimizu, T.; Izumi, T.; Seyama, Y.; Tadokoro, K.; Radmark, O.
Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase
Proc. Natl. Acad. Sci. USA
83
4175-4179
1986
Mus musculus
Rouzer, C.A.; Shimizu, T.; Samuelsson, B.
On the nature of the 5-lipoxygenase reaction in human leukocytes: characterization of a membrane-associated stimulatory factor
Proc. Natl. Acad. Sci. USA
82
7505-7509
1985
Homo sapiens
Corey, E.J.; Casman, J.R.; Eckrich, T.M.; Corey, D.R.
A new class of irreversible inhibitors of leukotriene biosynthesis
J. Am. Chem. Soc.
107
713-715
1985
Rattus norvegicus
-
Furukawa, M.; Yoshimoto, T.; Ochi, K.; Yamamoto, S.
Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells
Biochim. Biophys. Acta
795
458-465
1984
Rattus norvegicus
Corey, E.J.; Lansbury, P.T.; Cashman, J.R.; Kanter, S.S.
Mechanism of the irreversible deactivation of arachidonate 5-lipoxygenase by 5,6-dehydroarachidonate
J. Am. Chem. Soc.
106
1501-1503
1984
Rattus norvegicus
-
Borgeat, P.; Hamberg, M.; Samuelsson, B.
Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases
J. Biol. Chem.
251
7816-7820
1976
Oryctolagus cuniculus
Falgueyret, J.P.; Denis, D.; MacDonald, D.; Hutchinson, J.H.; Riendeau, D.
Characterization of the arachidonate and ATP binding sites of human 5-lipoxygenase using photoaffinity labeling and enzyme immobilization
Biochemistry
34
13603-13611
1995
Homo sapiens
Colamorea, T.; Di Paola, R.; Macchia, F.; Guerrese, M.C.; Tursi, A.; Butterfield, J.H.; Caiaffa, M.F.; Haeggstrom, J.Z.; Macchia, L.
5-Lipoxygenase Upregulation by Dexamethasone in Human Mast Cells
Biochem. Biophys. Res. Commun.
265
617-624
1999
Homo sapiens
Ochi, K.; Yoshimoto, Y.; Yamamoto, S.; Taniguchi, K.; Miyamoto, T.
Archidonate 5-lipoxygenase of guinea pig peritoneal polymorphonuclear leukocytes
J. Biol. Chem.
258
5754-5758
1983
Cavia porcellus
Brock, T.G.; McNish, R.W.; Peters-Golden, M.
Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages
J. Biol. Chem.
270
21652-21658
1995
Homo sapiens, Rattus norvegicus
Ghosh, J.; Myers, C.E.
Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells
Proc. Natl. Acad. Sci. USA
95
13182-13187
1998
Homo sapiens
Janssen-Timmen, U.; Vickers, P.J.; Wittig, U.; Lehmann, W.D.; Stark, H.J.; Fusenig, N.E.; Rosenbach, T.; Raedmark, O.; Samuelsson, B.; Habenicht, A.J.R.
Expression of 5-lipoxygenase in differentiating human skin keratinocytes
Proc. Natl. Acad. Sci. USA
92
6966-6970
1995
Homo sapiens
Brock, T.G.; Paine, R.; Peters-Golden, M.
Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells
J. Biol. Chem.
269
22059-22066
1994
Rattus norvegicus
Bell, R.L.; Harris, R.R.
The enzymology and pharmacology of 5-lipoxygenase and 5-lipoxygenase activating protein
Clin. Rev. Allergy Immunol.
17
91-109
1999
Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus scrofa
Walther, M.; Ivanov, I.; Myagkova, G.; Kuhn, H.
Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis
Chem. Biol.
8
779-790
2001
Homo sapiens
Mirzoeva, O.K.; Sud'ina, G.F.; Pushkareva, M.A.; Varfolomeev, S.D.
Competitive inhibition of the 5-lipoxygenase-catalysed linoleate oxidation by arachidonic and 5-hydroperoxy-eicosatetraenoic acids
FEBS Lett.
377
306-308
1995
Hordeum vulgare
Schwarz, K.; Gerth, C.; Anton, M.; Kuhn, H.
Alterations in Leukotriene Synthase Activity of the Human 5-Lipoxygenase by Site-Directed Mutagenesis Affecting Its Positional Specificity
Biochemistry
39
14515-14521
2000
Homo sapiens
Young, R.N.
Inhibitors of 5-lipoxygenase: a therapeutic potential yet to be fully realized?
Eur. J. Med. Chem.
34
671-685
1999
Homo sapiens
-
Wetterholm, A.; Macchia, L.; Haeggstrom, J.Z.
Zinc and other divalent cations inhibit purified leukotriene A4 hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes
Arch. Biochem. Biophys.
311
253-271
1994
Homo sapiens
-
Lammers, C.H.; Schweitzer, P.; Facchinetti, P.; Arrang, J.M.; Madamba, S.G.; Siggins, G.R.; Piomelli, D.
Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling
J. Neurochem.
66
147-152
1996
Rattus norvegicus
Zhang, Y.Y.; Lind, B.; Raadmark, O.; Samuelsson, B.
Iron content of human 5-lipoxygenase. Effects of mutations regarding conserved histidine residues
J. Biol. Chem.
268
2535-2541
1993
Homo sapiens
Radmark, O.
Arachidonate 5-lipoxygenase
Prostaglandins
68-69
211-234
2002
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Solanum tuberosum, Sus scrofa
Ghosh, J.
Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase
Biochem. Biophys. Res. Commun.
315
624-635
2004
Homo sapiens
Pande, A.H.; Moe, D.; Nemec, K.N.; Qin, S.; Tan, S.; Tatulian, S.A.
Modulation of human 5-lipoxygenase activity by membrane lipids
Biochemistry
43
14653-14666
2004
Homo sapiens
Brkert, E.; Szellas, D.; Radmark, O.; Steinhilber, D.; Werz, O.
Cell type-dependent activation of 5-lipoxygenase by arachidonic acid
J. Leukocyte Biol.
73
191-200
2003
Homo sapiens, Rattus norvegicus
Schneider, I.; Bucar, F.
Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenase/cyclooxygenase
Phytother. Res.
19
81-102
2005
Bos taurus, Cavia porcellus, Glycine max, Helianthus tuberosus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Hardy, G.; Vergnaud, S.; Lunardi, J.; Peoc'h, M.; Bessard, G.; Stanke-Labesque, F.
5-Lipoxygenase expression and activity in aorta from streptozotocin-induced diabetic rats
Prostaglandins
75
91-103
2005
Rattus norvegicus
Son, M.J.; Moon, T.C.; Lee, E.K.; Son, K.H.; Kim, H.P.; Kang, S.S.; Son, J.K.; Lee, S.H.; Chang, H.W.
Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells
Arch. Pharm. Res.
29
282-286
2006
Mus musculus
Grimm, E.L.; Brideau, C.; Chauret, N.; Chan, C.C.; Delorme, D.; Ducharme, Y.; Ethier, D.; Falgueyret, J.P.; Friesen, R.W.; Guay, J.; Hamel, P.; Riendeau, D.; Soucy-Breau, C.; Tagari, P.; Girard, Y.
Substituted coumarins as potent 5-lipoxygenase inhibitors
Bioorg. Med. Chem. Lett.
16
2528-2531
2006
Homo sapiens
Abe, M.; Ozawa, Y.; Uda, Y.; Morimitsu, Y.; Nakamura, Y.; Osawa, T.
A novel labdane-type trialdehyde from myoga (Zingiber mioga Roscoe) that potently inhibits human platelet aggregation and human 5-lipoxygenase
Biosci. Biotechnol. Biochem.
70
2494-2500
2006
Homo sapiens
Shirumalla R. , S.R.; Naruganahalli K. , N.K.; Dastidar S. , D.S.; Sattigeri , S.V.; Kaur , K.G.; Deb , D.C.; Gupta J. , G.J.; Salman , S.M.; Ray , R.A.
RBx 7796: A novel inhibitor of 5-lipoxygenase
Inflamm. Res.
55
517-527
2006
Homo sapiens
Butovich, I.A.; Lukyanova, S.M.; Bachmann, C.
Dihydroxydocosahexaenoic acids of the neuroprotectin D family: synthesis, structure, and inhibition of human 5-lipoxygenase
J. Lipid Res.
47
2462-2474
2006
Homo sapiens
Araico, A.; Terencio, M.C.; Alcaraz, M.J.; Dominguez, J.N.; Leon, C.; Ferrandiz, M.L.
Phenylsulphonyl urenyl chalcone derivatives as dual inhibitors of cyclo-oxygenase-2 and 5-lipoxygenase
Life Sci.
78
2911-2918
2006
Homo sapiens
Chen, T.; Shiao, M.; Pan, B.S.
Inhibition of 12- and 15-lipoxygenase activities and protection of human and tilapia low density lipoprotein oxidation by I-Tiao-Gung (Glycine tomentella)
Lipids
40
1171-1177
2005
Oreochromis niloticus
Poeckel, D.; Niedermeyer, T.H.; Pham, H.T.; Mikolasch, A.; Mundt, S.; Lindequist, U.; Lalk, M.; Werz, O.
Inhibition of human 5-lipoxygenase and anti-neoplastic effects by 2-amino-1,4-benzoquinones
Med. Chem.
2
591-595
2006
Homo sapiens
Rakonjac, M.; Fischer, L.; Provost, P.; Werz, O.; Steinhilber, D.; Samuelsson, B.; Radmark, O.
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production
Proc. Natl. Acad. Sci. USA
103
13150-13155
2006
Homo sapiens
Raghavenra, H.; Diwakr, B.T.; Lokesh, B.R.; Naidu, K.A.
Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells
Prostaglandins Leukot. Essent. Fatty Acids
74
23-27
2006
Homo sapiens
Frum, Y.; Viljoen, A.M.
In vitro 5-lipoxygenase and anti-oxidant activities of South African medicinal plants commonly used topically for skin diseases
Skin Pharmacol. Physiol.
19
329-335
2006
Homo sapiens
Pufahl, R.A.; Kasten, T.P.; Hills, R.; Gierse, J.K.; Reitz, B.A.; Weinberg, R.A.; Masferrer, J.L.
Development of a fluorescence-based enzyme assay of human 5-lipoxygenase
Anal. Biochem.
364
204-212
2007
Homo sapiens
Mahesha, H.G.; Singh, S.A.; Rao, A.G.
Inhibition of lipoxygenase by soy isoflavones: evidence of isoflavones as redox inhibitors
Arch. Biochem. Biophys.
461
176-185
2007
Homo sapiens
Huang, L.S.; Kim, M.R.; Jeong, T.S.; Sok, D.E.
Linoleoyl lysophosphatidic acid and linoleoyl lysophosphatidylcholine are efficient substrates for mammalian lipoxygenases
Biochim. Biophys. Acta
1770
1062-1070
2007
Solanum tuberosum
Zheng, M.; Zheng, M.; Ye, D.; Deng, Y.; Qiu, S.; Luo, X.; Chen, K.; Liu, H.; Jiang, H.
Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling
Bioorg. Med. Chem. Lett.
17
2414-2420
2007
Rattus norvegicus (P12527)
Belfiore, M.C.; Natoni, A.; Barzellotti, R.; Merendino, N.; Pessina, G.; Ghibelli, L.; Gualandi, G.
Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells
Cancer Lett.
254
236-243
2007
Homo sapiens
Gonzalez-Periz, A.; Claria, J.
New approaches to the modulation of the cyclooxygenase-2 and 5-lipoxygenase pathways
Curr. Top. Med. Chem.
7
297-309
2007
Homo sapiens
Gubitosi-Klug, R.A.; Talahalli, R.; Du, Y.; Nadler, J.L.; Kern, T.S.
5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy
Diabetes
57
1387-1393
2008
Mus musculus, Mus musculus C57BL/6
Scholz, M.; Ulbrich, H.K.; Dannhardt, G.
Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles
Eur. J. Med. Chem.
43
1152-1159
2008
Bos taurus
Adamek, A.; Jung, S.; Dienesch, C.; Laser, M.; Ertl, G.; Bauersachs, J.; Frantz, S.
Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice
Eur. J. Pharmacol.
571
51-54
2007
Mus musculus (P48999)
Herb, F.; Thye, T.; Niemann, S.; Browne, E.N.; Chinbuah, M.A.; Gyapong, J.; Osei, I.; Owusu-Dabo, E.; Werz, O.; Ruesch-Gerdes, S.; Horstmann, R.D.; Meyer, C.G.
ALOX5 variants associated with susceptibility to human pulmonary tuberculosis
Hum. Mol. Genet.
17
1052-1060
2008
Homo sapiens
Cook-Moreau, J.M.; El-Makhour Hojeij, Y.; Barriere, G.; Rabinovitch-Chable, H.C.; Faucher, K.S.; Sturtz, F.G.; Rigaud, M.A.
Expression of 5-lipoxygenase (5-LOX) in T lymphocytes
Immunology
122
157-166
2007
Homo sapiens
Huang, L.S.; Kim, M.R.; Sok, D.E.
Regulation of lipoxygenase activity by polyunsaturated lysophosphatidylcholines or their oxygenation derivatives
J. Agric. Food Chem.
56
7808-7814
2008
Solanum tuberosum
Ezekwudo, D.E.; Wang, R.C.; Elegbede, J.A.
Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway
J. Exp. Ther. Oncol.
6
267-277
2007
Homo sapiens
Lopez-Parra, M.; Titos, E.; Horrillo, R.; Ferre, N.; Gonzalez-Periz, A.; Martinez-Clemente, M.; Planaguma, A.; Masferrer, J.L.; Arroyo, V.; Claria, J.
Regulatory effects of arachidonate 5-lipoxygenase on hepatic MTP activity and VLDL-TG and ApoB secretion in obese mice
J. Lipid Res.
49
2513-2523
2008
Mus musculus (P48999), Mus musculus, Mus musculus C57/BL6J (P48999)
Franke, L.; Schwarz, O.; Mueller-Kuhrt, L.; Hoernig, C.; Fischer, L.; George, S.; Tanrikulu, Y.; Schneider, P.; Werz, O.; Steinhilber, D.; Schneider, G.
Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening
J. Med. Chem.
50
2640-2646
2007
Homo sapiens
Massi, P.; Valenti, M.; Vaccani, A.; Gasperi, V.; Perletti, G.; Marras, E.; Fezza, F.; Maccarrone, M.; Parolaro, D.
5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid
J. Neurochem.
104
1091-1100
2008
Homo sapiens, Hordeum vulgare
Vincent, C.; Fiancette, R.; Donnard, M.; Bordessoule, D.; Turlure, P.; Trimoreau, F.; Denizot, Y.
5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts
Leuk. Res.
32
1756-1762
2008
Homo sapiens
Chinnici, C.M.; Yao, Y.; Pratico, D.
The 5-lipoxygenase enzymatic pathway in the mouse brain: Young versus old
Neurobiol. Aging
28
1457-1462
2007
Mus musculus (P48999), Mus musculus, Mus musculus C57BL/6 (P48999)
Sudina, G.F.; Pushkareva, M.A.; Shephard, P.; Klein, T.
Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors
Prostaglandins Leukot. Essent. Fatty Acids
78
99-108
2008
Homo sapiens
Loetzer, K.; Jahn, S.; Kramer, C.; Hildner, M.; Nuesing, R.; Funk, C.D.; Habenicht, A.J.
5-Lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells
Prostaglandins Other Lipid Mediat.
84
108-115
2007
Homo sapiens
Michel, A.A.; Steinhilber, D.; Werz, O.
Development of a method for expression and purification of the regulatory C2-like domain of human 5-lipoxygenase
Protein Expr. Purif.
59
110-116
2008
Homo sapiens
Radmark, O.; Werz, O.; Steinhilber, D.; Samuelsson, B.
5-Lipoxygenase: regulation of expression and enzyme activity
Trends Biochem. Sci.
32
332-341
2007
Mus musculus, Rattus norvegicus, Homo sapiens (P09917)
Koeberle, A.; Zettl, H.; Greiner, C.; Wurglics, M.; Schubert-Zsilavecz, M.; Werz, O.
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase
J. Med. Chem.
51
8068-8076
2008
Homo sapiens
Strid, T.; Svartz, J.; Franck, N.; Hallin, E.; Ingelsson, B.; Soederstroem, M.; Hammarstroem, S.
Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein
Biochem. Biophys. Res. Commun.
381
518-522
2009
Homo sapiens
Macdonald, D.; Brideau, C.; Chan, C.C.; Falgueyret, J.P.; Frenette, R.; Guay, J.; Hutchinson, J.H.; Perrier, H.; Prasit, P.; Riendeau, D.; Tagari, P.; Therien, M.; Young, R.N.; Girard, Y.
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein
Bioorg. Med. Chem. Lett.
18
2023-2027
2008
Homo sapiens
Doiron, J.; Boudreau, L.H.; Picot, N.; Villebonet, B.; Surette, M.E.; Touaibia, M.
Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters
Bioorg. Med. Chem. Lett.
19
1118-1121
2009
Homo sapiens
Reddy, M.V.; Billa, V.K.; Pallela, V.R.; Mallireddigari, M.R.; Boominathan, R.; Gabriel, J.L.; Reddy, E.P.
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors
Bioorg. Med. Chem.
16
3907-3916
2008
Oryctolagus cuniculus, Homo sapiens
Mahshid, Y.; Lisy, M.; Wang, X.; Spanbroek, R.; Flygare, J.; Christensson, B.; Bjoerkholm, M.; Sander, B.; Habenicht, A.; Claesson, H.
High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes
BMC Immunol.
10
2-2
2009
Homo sapiens
Borges, C.L.; Cecchini, R.; Tatakihara, V.L.; Malvezi, A.D.; Yamada-Ogatta, S.F.; Rizzo, L.V.; Pinge-Filho, P.
5-Lipoxygenase plays a role in the control of parasite burden and contributes to oxidative damage of erythrocytes in murine Chagas disease
Immunol. Lett.
123
38-45
2009
Mus musculus
Jian, W.; Lee, S.H.; Williams, M.V.; Blair, I.A.
5-Lipoxygenase-mediated endogenous DNA damage
J. Biol. Chem.
284
16799-16807
2009
Homo sapiens
Aparoy, P.; Reddy, R.N.; Guruprasad, L.; Reddy, M.R.; Reddanna, P.
Homology modeling of 5-lipoxygenase and hints for better inhibitor design
J. Comput. Aided Mol. Des.
22
611-619
2008
Solanum tuberosum
Radmark, O.; Samuelsson, B.
5-Lipoxygenase: mechanisms of regulation
J. Lipid Res.
50 Suppl
S40-S45
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Chowdhury, M.A.; Abdellatif, K.R.; Dong, Y.; Das, D.; Suresh, M.R.; Knaus, E.E.
Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity
J. Med. Chem.
52
1525-1529
2009
Solanum tuberosum
Karg, E.M.; Luderer, S.; Pergola, C.; Buehring, U.; Rossi, A.; Northoff, H.; Sautebin, L.; Troschuetz, R.; Werz, O.
Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase
J. Med. Chem.
52
3474-3483
2009
Homo sapiens, Rattus norvegicus
Liedtke, A.J.; Keck, P.R.; Lehmann, F.; Koeberle, A.; Werz, O.; Laufer, S.A.
Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX)
J. Med. Chem.
52
4968-4972
2009
Homo sapiens
Knaup, B.; Oehme, A.; Valotis, A.; Schreier, P.
Anthocyanins as lipoxygenase inhibitors
Mol. Nutr. Food Res.
53
617-624
2009
Homo sapiens
Leifert, W.; Abeywardena, M.
Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity
Nutr. Res.
28
729-737
2008
Glycine max
Chen, S.H.; Fahmi, H.; Shi, Q.; Benderdour, M.
Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes
Arthritis Res. Ther.
12
R21
2010
Homo sapiens
Choi, J.H.; Jeon, H.J.; Park, J.G.; Sonn, S.K.; Lee, M.R.; Lee, M.N.; You, H.J.; Kim, G.Y.; Kim, J.H.; Lee, M.H.; Kwon, O.S.; Nam, K.H.; Kim, H.C.; Jeong, T.S.; Lee, W.S.; Oh, G.T.
Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice
Atherosclerosis
212
146-152
2010
Mus musculus
Radmark, O.; Samuelsson, B.
Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis
Biochem. Biophys. Res. Commun.
396
105-110
2010
Homo sapiens
Esser, J.; Rakonjac, M.; Hofmann, B.; Fischer, L.; Provost, P.; Schneider, G.; Steinhilber, D.; Samuelsson, B.; Radmark, O.
Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: Role of tryptophan 102
Biochem. J.
425
265-274
2010
Homo sapiens
Katryniok, C.; Schnur, N.; Gillis, A.; von Knethen, A.; Sorg, B.; Looijenga, L.; Radmark, O.; Steinhilber, D.
Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity
Biochim. Biophys. Acta
1801
49-57
2010
Homo sapiens
Aparoy, P.; Kumar Reddy, K.; Kalangi, S.K.; Chandramohan Reddy, T.; Reddanna, P.
Pharmacophore modeling and virtual screening for designing potential 5-lipoxygenase inhibitors
Bioorg. Med. Chem. Lett.
20
1013-1018
2010
Solanum tuberosum
Yu, G.; Praveen Rao, P.N.; Chowdhury, M.A.; Abdellatif, K.R.; Dong, Y.; Das, D.; Velazquez, C.A.; Suresh, M.R.; Knaus, E.E.
Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase
Bioorg. Med. Chem. Lett.
20
2168-2173
2010
Solanum tuberosum
Yu, G.; Chowdhury, M.A.; Abdellatif, K.R.; Dong, Y.; Praveen Rao, P.N.; Das, D.; Velazquez, C.A.; Suresh, M.R.; Knaus, E.E.
Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity
Bioorg. Med. Chem. Lett.
20
896-902
2010
Solanum tuberosum
Fischer, A.S.; Metzner, J.; Steinbrink, S.D.; Ulrich, S.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Maier, T.J.
5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity
Br. J. Pharmacol.
161
936-949
2010
Homo sapiens
Shin, V.Y.; Jin, H.C.; Ng, E.K.; Sung, J.J.; Chu, K.M.; Cho, C.H.
Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth
Cancer Lett.
292
237-245
2010
Homo sapiens
Steinbrink, S.D.; Pergola, C.; Buehring, U.; George, S.; Metzner, J.; Fischer, A.S.; Haefner, A.K.; Wisniewska, J.M.; Geisslinger, G.; Werz, O.; Steinhilber, D.; Maier, T.J.
Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations
Cell. Mol. Life Sci.
67
797-806
2010
Homo sapiens
Marruchella, G.; Giacominelli-Stuffler, R.; Baffoni, M.; Maccarrone, M.
5-Lipoxygenase and cyclooxygenase-2 in porcine parasitic bronchopneumonia: immunohistochemical and biochemical investigations
J. Comp. Pathol.
142
139-146
2010
Sus scrofa
Radmark, O.; Samuelsson, B.
Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer
J. Intern. Med.
268
5-14
2010
Homo sapiens
Pavanelli, W.R.; Gutierrez, F.R.; Mariano, F.S.; Prado, C.M.; Ferreira, B.R.; Teixeira, M.M.; Canetti, C.; Rossi, M.A.; Cunha, F.Q.; Silva, J.S.
5-Lipoxygenase is a key determinant of acute myocardial inflammation and mortality during Trypanosoma cruzi infection
Microbes Infect.
12
587-597
2010
Mus musculus
Cho, Y.S.; Kim, C.H.; Surh, J.H.; Kang, N.S.; Yoo, S.E.; Cheon, H.G.
Identification of 4-[4-(4-fluoro-phenyl)-thiazol-2-ylamino]-2,6-dimethyl-phenol (KR-33749) as an inhibitor of 5-lipoxygenase with potent antiinflammatory activity
Pharmacology
86
65-72
2010
Rattus norvegicus
Kim, C.E.; Lee, S.J.; Seo, K.W.; Park, H.M.; Yun, J.W.; Bae, J.U.; Bae, S.S.; Kim, C.D.
Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway
Toxicol. Appl. Pharmacol.
245
76-82
2010
Mus musculus
Walther, M.; Hofheinz, K.; Vogel, R.; Roffeis, J.; Kuehn, H.
The N-terminal beta-barrel domain of mammalian lipoxygenases including mouse 5-lipoxygenase is not essential for catalytic activity and membrane binding but exhibits regulatory functions
Arch. Biochem. Biophys.
516
1-9
2011
Mus musculus
Chen, Y.P.; Zhang, Z.Y.; Li, Y.P.; Li, D.; Huang, S.L.; Gu, L.Q.; Xu, J.; Huang, Z.S.
Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase
Eur. J. Med. Chem.
66
22-31
2013
Solanum tuberosum
Filosa, R.; Peduto, A.; Aparoy, P.; Schaible, A.M.; Luderer, S.; Krauth, V.; Petronzi, C.; Massa, A.; de Rosa, M.; Reddanna, P.; Werz, O.
Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase
Eur. J. Med. Chem.
67
269-279
2013
Homo sapiens
Hofmann, B.; Barzen, S.; Roedl, C.B.; Kiehl, A.; Borig, J.; Zivkovic, A.; Stark, H.; Schneider, G.; Steinhilber, D.
A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors
J. Med. Chem.
54
1943-1947
2011
Homo sapiens
Khairullina, V.; Taipov, I.; Gerchikov, A.; Zarudii, F.
Structure-activity relationship in a series of natural and synthetic inhibitors of 5-lipoxygenase catalytic activity
Pharm. Chem. J.
46
553-564
2012
Rattus norvegicus
-
Kretschmer, S.B.M; Woltersdorf, S.; Vogt, D.; Lillich, F.F.; Ruehl, M.; Karas, M.; Maucher, I.V.; Roos, J.; Haefner, A.-K.; Kaiser, A.; Wurglics, M.; Schubert-Zsilavecz, M.; Angioni, C.; Geisslinger, G.; Stark, H.; Steinhilber, D.; Hofmann, B.
Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles
Biochem. Pharmacol.
123
52-62
2017
Homo sapiens (P09917), Homo sapiens
Khayrullina, V.R.; Taipov, I.A.; Veselovsky, A.V.; Shcherbinin, D.S.; Gerchikov, A.Y.
New inhibitors of 5-lipoxygenase catalytic activity based on 2-(3-methylphenyl)propanoic acid and 4-substituted morpholine derivatives
Biochemistry (Moscow)
79
376-384
2014
Homo sapiens (P09917)
Smyrniotis, C.J.; Barbour, S.R.; Xia, Z.; Hixon, M.S.; Holman, T.R.
ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid
Biochemistry
53
4407-4419
2014
Homo sapiens (P09917), Homo sapiens
Mitra, S.; Bartlett, S.G.; Newcomer, M.E.
Identification of the substrate access portal of 5-lipoxygenase
Biochemistry
54
6333-6342
2015
Homo sapiens (P09917)
Schroeder, M.; Haefner, A.K.; Hofmann, B.; Radmark, O.; Tumulka, F.; Abele, R.; Doetsch, V.; Steinhilber, D.
Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase
Biochim. Biophys. Acta
1842
1538-1547
2014
Homo sapiens (P09917), Homo sapiens
Haefner, A.K.; Gerstmeier, J.; Hoernig, M.; George, S.; Ball, A.K.; Schroeder, M.; Garscha, U.; Werz, O.; Steinhilber, D.
Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP
Biochim. Biophys. Acta
1851
1465-1472
2015
Homo sapiens (P09917), Homo sapiens
Ball, A.K.; Beilstein, K.; Wittmann, S.; Sueruen, D.; Saul, M.J.; Schnuetgen, F.; Flamand, N.; Capelo, R.; Kahnt, A.S.; Frey, H.; Schaefer, L.; Marschalek, R.; Haefner, A.K.; Steinhilber, D.
Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LODELTA13, 5-LODELTA4 and 5-LOp12
Biochim. Biophys. Acta
1862
561-571
2017
Homo sapiens (P09917), Homo sapiens
Shang, E.; Liu, Y.; Wu, Y.; Zhu, W
; He, C.; Lai, L. Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors
Bioorg. Med. Chem.
22
2396-2402
2014
Homo sapiens (P09917), Homo sapiens
Mittal, M.; Kumar, R.B.; Balagunaseelan, N.; Hamberg, M.; Jegerschoeld, C.; Radmark, O.; Haeggstroem, J.Z.; Rinaldo-Matthis, A.
Kinetic investigation of human 5-lipoxygenase with arachidonic acid
Bioorg. Med. Chem. Lett.
26
3547-3551
2016
Homo sapiens (P09917), Homo sapiens
Torras, J.; Maccarrone, M.; Dainese, E.
Molecular dynamics study on the apo- and holo-forms of 5-lipoxygenase
Biotechnol. Appl. Biochem.
65
54-61
2017
Homo sapiens (P09917)
Pergola, C.; Gerstmeier, J.; Moench, B.; Caliskan, B.; Luderer, S.; Weinigel, C.; Barz, D.; Maczewsky, J.; Pace, S.; Rossi, A.; Sautebin, L.; Banoglu, E.; Werz, O.
The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP)
Br. J. Pharmacol.
171
3051-3064
2014
Homo sapiens (P09917)
Wang, T.; Zuo, R.; Mai, K.; Xu, W.; Ai, Q.
Molecular cloning and functional characterization of arachidonate 5-lipoxygenase (Alox5), and its expression in response to the ratio of linolenic acid to linoleic acid in diets of large yellow croaker (Larmichthys crocea)
Comp. Biochem. Physiol. B
201
21-28
2016
Larimichthys crocea (A0A075C1I3), Larimichthys crocea
Peduto, A.; Scuotto, M.; Krauth, V.; Roviezzo, F.; Rossi, A.; Temml, V.; Esposito, V.; Stuppner, H.; Schuster, D.; D'Agostino, B.; Schiraldi, C.; de Rosa, M.; Werz, O.; Filosa, R.
Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase
Eur. J. Med. Chem.
127
715-726
2017
Homo sapiens (P09917), Homo sapiens
Peduto, A.; Bruno, F.; Dehm, F.; Krauth, V.; de Caprariis, P.; Weinigel, C.; Barz, D.; Massa, A.; De Rosa, M.; Werz, O.; Filosa, R.
Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase
Eur. J. Med. Chem.
81
492-498
2014
Homo sapiens (P09917), Homo sapiens
Ho, X.L.; Liu, J.J.; Loke, W.M.
Plant sterol-enriched soy milk consumption modulates 5-lipoxygenase, 12-lipoxygenase, and myeloperoxidase activities in healthy adults - a randomized-controlled trial
Free Radic. Res.
50
1396-1407
2016
Homo sapiens (P09917)
Schieferdecker, S.; Koenig, S.; Koeberle, A.; Dahse, H.-M.; Werz, O.; Nett, M.
Myxochelins target human 5-lipoxygenase
J. Nat. Prod.
78
335-338
2015
Homo sapiens (P09917), Homo sapiens
Meirer, K.; Glatzel, D.; Kretschmer, S.; Wittmann, S.K.; Hartmann, M.; Bloecher, R.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Hofmann, B.; Fuerst, R.; Proschak, E.
Design, synthesis and cellular characterization of a dual inhibitor of 5-lipoxygenase and soluble epoxide hydrolase
Molecules
22
45
2016
Homo sapiens (P09917)
Chagas-Paula, D.A.; Oliveira, T.B.; Faleiro, D.P.V.; Oliveira, R.B.; Da Costa, F.B.
Outstanding anti-inflammatory potential of selected Asteraceae species through the potent dual inhibition of cyclooxygenase-1 and 5-lipoxygenase
Planta Med.
81
1296-1307
2015
Homo sapiens (P09917)
Allain, E.P.; Boudreau, L.H.; Flamand, N.; Surette, M.E.
The Intracellular localisation and phosphorylation profile of the human 5-lipoxygenase DELTA13 isoform differs from that of its full length counterpart
PLoS ONE
10
e0132607
2015
Homo sapiens (P09917), Homo sapiens
Haefner, A.K.; Beilstein, K.; Graab, P.; Ball, A.K.; Saul, M.J.; Hofmann, B.; Steinhilber, D.
Identification and characterization of a new protein isoform of human 5-lipoxygenase
PLoS ONE
11
e0166591
2016
Homo sapiens (P09917), Homo sapiens
Nandha, B.; Ramareddy, S.A.; Kuntal, H.
Synthesis of substituted fluorobenzimidazoles as inhibitors of 5-lipoxygenase and soluble epoxide hydrolase for anti-inflammatory activity
Arch. Pharm.
351
e1800030
2018
Glycine max
Maucher, I.V.; Ruehl, M.; Kretschmer, S.B.; Hofmann, B.; Kuehn, B.; Fettel, J.; Vogel, A.; Fluegel, K.T.; Manolikakes, G.; Hellmuth, N.; Haefner, A.K.; Golghalyani, V.; Ball, A.K.; Piesche, M.; Matrone, C.; Geisslinger, G.; Parnham, M.J.; Karas, M.; Steinhilber, D.; Roos, J.; Maier, T.J.
Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418
Biochem. Pharmacol.
125
55-74
2017
Homo sapiens (P09917), Homo sapiens
Green, A.R.; Freedman, C.; Tena, J.; Tourdot, B.E.; Liu, B.; Holinstat, M.; Holman, T.R.
5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a lipoxin intermediate Reactivity and kinetics with human leukocyte 5-lipoxygenase, platelet 12-lipoxygenase, and reticulocyte 15-lipoxygenase-1
Biochemistry
57
6726-6734
2018
Homo sapiens (P09917), Homo sapiens
Perry, S.C.; Horn, T.; Tourdot, B.E.; Yamaguchi, A.; Kalyanaraman, C.; Conrad, W.S.; Akinkugbe, O.; Holinstat, M.; Jacobson, M.P.; Holman, T.R.
Role of human 15-lipoxygenase-2 in the biosynthesis of the lipoxin intermediate, 5S,15S-diHpETE, implicated with the altered positional specificity of human 15-lipoxygenase-1
Biochemistry
59
4118-4130
2020
Homo sapiens (P09917)
El-Nagar, M.K.S.; Abdu-Allah, H.H.M.; Salem, O.I.A.; Kafafy, A.N.; Farghaly, H.S.M.
Novel N-substituted 5-aminosalicylamides as dual inhibitors of cyclooxygenase and 5-lipoxygenase enzymes Synthesis, biological evaluation and docking study
Bioorg. Chem.
78
80-93
2018
Solanum tuberosum
Doiron, J.A.; Leblanc, L.M.; Hebert, M.J.; Levesque, N.A.; Pare, A.F.; Jean-Francois, J.; Cormier, M.; Surette, M.E.; Touaibia, M.
Structure-activity relationship of caffeic acid phenethyl ester analogs as new 5-lipoxygenase inhibitors
Chem. Biol. Drug Des.
89
514-528
2017
Homo sapiens (P09917)
Selka, A.; Doiron, J.A.; Lyons, P.; Dastous, S.; Chiasson, A.; Cormier, M.; Turcotte, S.; Surette, M.E.; Touaibia, M.
Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells
Eur. J. Med. Chem.
179
347-357
2019
Homo sapiens (P09917)
Dinh, C.P.; Ville, A.; Neukirch, K.; Viault, G.; Temml, V.; Koeberle, A.; Werz, O.; Schuster, D.; Stuppner, H.; Richomme, P.; Helesbeux, J.J.; Seraphin, D.
Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors
Eur. J. Med. Chem.
202
112518
2020
Homo sapiens (P09917), Homo sapiens
Echeverria, J.; Urzua, A.
Inhibition of soybean 15-lipoxygenase and human 5-lipoxygenase by extracts of leaves, stem bark, phenols and catechols isolated from Lithraea caustica (Anacardiaceae)
Front. Pharmacol.
11
594257
2020
Homo sapiens (P09917), Homo sapiens
Roy, P.; Faye, D.; Blanchard, S.; Cormier, M.; Doiron, J.; Surette, M.; Touaibia, M.
New caffeic acid phenylethyl ester analogs bearing substituted triazole Synthesis and structure-activity relationship study towards 5-lipoxygenase inhibition
J. Chem.
2017
2380531
2017
Homo sapiens (P09917)
-
Phillips, O.A.; Bosso, M.A.; Ezeamuzie, C.I.
Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors
J. Enzyme Inhib. Med. Chem.
35
1471-1482
2020
Homo sapiens (P09917), Homo sapiens
Hiesinger, K.; Kramer, J.S.; Beyer, S.; Eckes, T.; Brunst, S.; Flauaus, C.; Wittmann, S.K.; Weizel, L.; Kaiser, A.; Kretschmer, S.B.M.; George, S.; Angioni, C.; Heering, J.; Geisslinger, G.; Schubert-Zsilavecz, M.; Schmidtko, A.; Pogoryelov, D.; Pfeilschifter, J.; Hofmann, B.; Steinhilber, D.; Sch, S.c.h.w.
Design, synthesis, and structure-activity relationship studies of dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase
J. Med. Chem.
63
11498-11521
2020
Homo sapiens (P09917), Homo sapiens
Park, N.Y.; Im, S.; Jiang, Q.
Different forms of vitamin E and metabolite 13-carboxychromanols inhibit cyclooxygenase-1 and its catalyzed thromboxane in platelets, and tocotrienols and 13-carboxychromanols are competitive inhibitors of 5-lipoxygenase
J. Nutr. Biochem.
100
108884
2022
Homo sapiens (P09917)
Gilbert, N.C.; Gerstmeier, J.; Schexnaydre, E.E.; Boerner, F.; Garscha, U.; Neau, D.B.; Werz, O.; Newcomer, M.E.
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products
Nat. Chem. Biol.
16
783-790
2020
Homo sapiens (P09917), Homo sapiens
Munoz-Osses, M.; Quiroz, J.; Vasquez-Martixadnez, Y.; Flores, E.; Navarrete, E.; Godoy, F.; Torrent, C.; Cortez-San Martin, M.; Gomez, A.; Mascayano, C.
Evaluation of cyrhetrenyl and ferrocenyl precursors as 5-lipoxygenase inhibitors - biological and computational studies
New J. Chem.
45
13360-13368
2021
Homo sapiens (P09917)
-
Mbarik, M.; Poirier, S.; Doiron, J.; Selka, A.; Barnett, D.; Cormier, M.; Touaibia, M.; Surette, M.
Phenolic acid phenethylesters and their corresponding ketones Inhibition of 5-lipoxygenase and stability in human blood and HepaRG cells
Pharmacol. Res. Perspect.
7
e00524
2019
Homo sapiens (P09917), Homo sapiens
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