Reference on EC 1.13.11.34 - arachidonate 5-lipoxygenase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
DeWolf, W.E.
Enzymatic studies on purified 5-lipoxygenase
Lipoxygenases and Their Products (Crooke, S. T. ed. ) Academic Press
105-135
1991
Cavia porcellus, Homo sapiens, Rattus norvegicus, Sus scrofa
-
Denis, D.; Falgueyret, J.P.; Riendeau, D.; Abramovitz, M.
Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors
J. Biol. Chem.
266
5072-5079
1991
Homo sapiens
Reddanna, P.; Whelan, J.; Maddipati, K.R.; Reddy, C.C.
Purification of arachidonate 5-lipoxygenase from potato tubers
Methods Enzymol.
187
268-277
1990
Solanum tuberosum
Shimizu, T.; Honda, Z.I.; Miki, I.; Seyama, Y.; Izumi, T.; Radmark, O.; Samuelsson, B.
Potato arachidonate 5-lipoxygenase: purification, characterization, and preparation of 5(S)-hydroperoxyeicosatetraenoic acid
Methods Enzymol.
187
296-306
1990
Solanum tuberosum
Rouzer, C.A.; Samuelsson, B.
Leukocyte arachidonate 5-lipoxygenase: isolation and characterization
Methods Enzymol.
187
312-319
1990
Homo sapiens
Ueda, N.; Yamamoto, S.
Immunoaffinity purification of arachidonate 5-lipoxygenase from porcine leukocytes
Methods Enzymol.
187
338-343
1990
Sus scrofa
Riendeau, D.; Falgueyret, J.P.; Nathaniel, D.J.; Rokach, J.; Ueda, N.; Yamamoto, S.
Sensitivity of immunoaffinity-purified porcine 5-lipoxygenase to inhibitors and activating lipid hydroperoxides
Biochem. Pharmacol.
38
2313-2321
1989
Sus scrofa
McMillan, R.M.; Masters, D.J.; Vickers, V.C.; Dicken, M.P.; Jacobs, V.N.
Metabolism of unsaturated fatty acids by RBL-1 5-lipoxygenase: influence of substrate solubility and product inactivation
Biochim. Biophys. Acta
1005
170-176
1989
Rattus norvegicus
Denis, D.; Choo, L.Y.; Riendeau, D.
Activation of 5-lipoxygenase by guanosine 5-O-(3-thiotriphosphate) and other nucleoside phosphorothioates: redox properties of thionucleotide analogs
Arch. Biochem. Biophys.
273
592-596
1989
Rattus norvegicus
Reddanna, P.; Whelan, J.; Reddy, P.S.; Reddy, C.C
Isolation and characterization of 5-lipoxygenase from tulip bulbs
Biochem. Biophys. Res. Commun.
157
1348-1351
1988
Tulipa hybrid cultivar
Cashman, J.R.; Lambert, C.; Sigal, E.
Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids
Biochem. Biophys. Res. Commun.
155
38-44
1988
Homo sapiens
Rouzer, C.A.; Rands, E.; Kargman, S.; Jones, R.E.; Register, R.B.; Dixon, R.A.F.
Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells
J. Biol. Chem.
263
10135-10140
1988
Homo sapiens
Haurand, M.; Flohe, L.
Kinetic studies on arachidonate 5-lipoxygenase from rat basophilic leukemia cells
Biol. Chem. Hoppe-Seyler
369
133-142
1988
Rattus norvegicus
Masters, D.J.; Jacobs, V.N.; Carr, V.J.; McMillan, R.M.
Kinetics of 5-lipoxygenase: influence of substrate solubility and product inactivation
Biochem. Soc. Trans.
16
38-39
1988
Rattus norvegicus
-
Soberman, R.J.
5- and 15(omega-6)-lipoxygenases from human polymorphonuclear leukocytes
Methods Enzymol.
163
344-349
1988
Homo sapiens
Ueda, N.; Yamamoto, S.
The 6R-oxygenase activity of arachidonate 5-lipoxygenase purified from porcine leukocytes
J. Biol. Chem.
263
1937-1941
1988
Sus scrofa
Skoog, M.T.; Nichols, J.S.; Wiseman, J.S.
5-Lipoxygenase from rat PMN lysate
Prostaglandins
31
561-576
1986
Rattus norvegicus
Mulliez, E.; Leblanc, J.P.; Girerd, J.J.; Rigaud, M.; Chottard, J.C.
5-Lipoxygenase from potato tubers. Improved purification and physicochemical characteristics
Biochim. Biophys. Acta
916
13-23
1987
Solanum tuberosum
-
Wiseman, J.S.; Skoog, M.T.; Nichols, J.S.; Harrison, B.L.
Kinetics of leukotriene A4 synthesis by 5-lipoxygenase from rat polymorphonuclear leukocytes
Biochemistry
26
5684-5689
1987
Rattus norvegicus
Ueda, N.; Kaneko, S.; Yoshimoto, T.; Yamamoto.S.
Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids
J. Biol. Chem.
261
7982-7988
1986
Sus scrofa
Aharony, D.; Stein.R.L.
Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase
J. Biol. Chem.
261
11512-11519
1986
Cavia porcellus
Shimizu, T.; Izumi, T.; Seyama, Y.; Tadokoro, K.; Radmark, O.
Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase
Proc. Natl. Acad. Sci. USA
83
4175-4179
1986
Mus musculus
Rouzer, C.A.; Shimizu, T.; Samuelsson, B.
On the nature of the 5-lipoxygenase reaction in human leukocytes: characterization of a membrane-associated stimulatory factor
Proc. Natl. Acad. Sci. USA
82
7505-7509
1985
Homo sapiens
Corey, E.J.; Casman, J.R.; Eckrich, T.M.; Corey, D.R.
A new class of irreversible inhibitors of leukotriene biosynthesis
J. Am. Chem. Soc.
107
713-715
1985
Rattus norvegicus
-
Furukawa, M.; Yoshimoto, T.; Ochi, K.; Yamamoto, S.
Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells
Biochim. Biophys. Acta
795
458-465
1984
Rattus norvegicus
Corey, E.J.; Lansbury, P.T.; Cashman, J.R.; Kanter, S.S.
Mechanism of the irreversible deactivation of arachidonate 5-lipoxygenase by 5,6-dehydroarachidonate
J. Am. Chem. Soc.
106
1501-1503
1984
Rattus norvegicus
-
Borgeat, P.; Hamberg, M.; Samuelsson, B.
Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases
J. Biol. Chem.
251
7816-7820
1976
Oryctolagus cuniculus
Falgueyret, J.P.; Denis, D.; MacDonald, D.; Hutchinson, J.H.; Riendeau, D.
Characterization of the arachidonate and ATP binding sites of human 5-lipoxygenase using photoaffinity labeling and enzyme immobilization
Biochemistry
34
13603-13611
1995
Homo sapiens
Colamorea, T.; Di Paola, R.; Macchia, F.; Guerrese, M.C.; Tursi, A.; Butterfield, J.H.; Caiaffa, M.F.; Haeggstrom, J.Z.; Macchia, L.
5-Lipoxygenase Upregulation by Dexamethasone in Human Mast Cells
Biochem. Biophys. Res. Commun.
265
617-624
1999
Homo sapiens
Ochi, K.; Yoshimoto, Y.; Yamamoto, S.; Taniguchi, K.; Miyamoto, T.
Archidonate 5-lipoxygenase of guinea pig peritoneal polymorphonuclear leukocytes
J. Biol. Chem.
258
5754-5758
1983
Cavia porcellus
Brock, T.G.; McNish, R.W.; Peters-Golden, M.
Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages
J. Biol. Chem.
270
21652-21658
1995
Homo sapiens, Rattus norvegicus
Ghosh, J.; Myers, C.E.
Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells
Proc. Natl. Acad. Sci. USA
95
13182-13187
1998
Homo sapiens
Janssen-Timmen, U.; Vickers, P.J.; Wittig, U.; Lehmann, W.D.; Stark, H.J.; Fusenig, N.E.; Rosenbach, T.; Raedmark, O.; Samuelsson, B.; Habenicht, A.J.R.
Expression of 5-lipoxygenase in differentiating human skin keratinocytes
Proc. Natl. Acad. Sci. USA
92
6966-6970
1995
Homo sapiens
Brock, T.G.; Paine, R.; Peters-Golden, M.
Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells
J. Biol. Chem.
269
22059-22066
1994
Rattus norvegicus
Bell, R.L.; Harris, R.R.
The enzymology and pharmacology of 5-lipoxygenase and 5-lipoxygenase activating protein
Clin. Rev. Allergy Immunol.
17
91-109
1999
Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus scrofa
Walther, M.; Ivanov, I.; Myagkova, G.; Kuhn, H.
Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis
Chem. Biol.
8
779-790
2001
Homo sapiens
Mirzoeva, O.K.; Sud'ina, G.F.; Pushkareva, M.A.; Varfolomeev, S.D.
Competitive inhibition of the 5-lipoxygenase-catalysed linoleate oxidation by arachidonic and 5-hydroperoxy-eicosatetraenoic acids
FEBS Lett.
377
306-308
1995
Hordeum vulgare
Schwarz, K.; Gerth, C.; Anton, M.; Kuhn, H.
Alterations in Leukotriene Synthase Activity of the Human 5-Lipoxygenase by Site-Directed Mutagenesis Affecting Its Positional Specificity
Biochemistry
39
14515-14521
2000
Homo sapiens
Young, R.N.
Inhibitors of 5-lipoxygenase: a therapeutic potential yet to be fully realized?
Eur. J. Med. Chem.
34
671-685
1999
Homo sapiens
-
Wetterholm, A.; Macchia, L.; Haeggstrom, J.Z.
Zinc and other divalent cations inhibit purified leukotriene A4 hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes
Arch. Biochem. Biophys.
311
253-271
1994
Homo sapiens
-
Lammers, C.H.; Schweitzer, P.; Facchinetti, P.; Arrang, J.M.; Madamba, S.G.; Siggins, G.R.; Piomelli, D.
Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling
J. Neurochem.
66
147-152
1996
Rattus norvegicus
Zhang, Y.Y.; Lind, B.; Raadmark, O.; Samuelsson, B.
Iron content of human 5-lipoxygenase. Effects of mutations regarding conserved histidine residues
J. Biol. Chem.
268
2535-2541
1993
Homo sapiens
Radmark, O.
Arachidonate 5-lipoxygenase
Prostaglandins
68-69
211-234
2002
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Solanum tuberosum, Sus scrofa
Ghosh, J.
Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase
Biochem. Biophys. Res. Commun.
315
624-635
2004
Homo sapiens
Pande, A.H.; Moe, D.; Nemec, K.N.; Qin, S.; Tan, S.; Tatulian, S.A.
Modulation of human 5-lipoxygenase activity by membrane lipids
Biochemistry
43
14653-14666
2004
Homo sapiens
Brkert, E.; Szellas, D.; Radmark, O.; Steinhilber, D.; Werz, O.
Cell type-dependent activation of 5-lipoxygenase by arachidonic acid
J. Leukocyte Biol.
73
191-200
2003
Homo sapiens, Rattus norvegicus
Schneider, I.; Bucar, F.
Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenase/cyclooxygenase
Phytother. Res.
19
81-102
2005
Bos taurus, Cavia porcellus, Glycine max, Helianthus tuberosus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Hardy, G.; Vergnaud, S.; Lunardi, J.; Peoc'h, M.; Bessard, G.; Stanke-Labesque, F.
5-Lipoxygenase expression and activity in aorta from streptozotocin-induced diabetic rats
Prostaglandins
75
91-103
2005
Rattus norvegicus
Son, M.J.; Moon, T.C.; Lee, E.K.; Son, K.H.; Kim, H.P.; Kang, S.S.; Son, J.K.; Lee, S.H.; Chang, H.W.
Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells
Arch. Pharm. Res.
29
282-286
2006
Mus musculus
Grimm, E.L.; Brideau, C.; Chauret, N.; Chan, C.C.; Delorme, D.; Ducharme, Y.; Ethier, D.; Falgueyret, J.P.; Friesen, R.W.; Guay, J.; Hamel, P.; Riendeau, D.; Soucy-Breau, C.; Tagari, P.; Girard, Y.
Substituted coumarins as potent 5-lipoxygenase inhibitors
Bioorg. Med. Chem. Lett.
16
2528-2531
2006
Homo sapiens
Abe, M.; Ozawa, Y.; Uda, Y.; Morimitsu, Y.; Nakamura, Y.; Osawa, T.
A novel labdane-type trialdehyde from myoga (Zingiber mioga Roscoe) that potently inhibits human platelet aggregation and human 5-lipoxygenase
Biosci. Biotechnol. Biochem.
70
2494-2500
2006
Homo sapiens
Shirumalla R. , S.R.; Naruganahalli K. , N.K.; Dastidar S. , D.S.; Sattigeri , S.V.; Kaur , K.G.; Deb , D.C.; Gupta J. , G.J.; Salman , S.M.; Ray , R.A.
RBx 7796: A novel inhibitor of 5-lipoxygenase
Inflamm. Res.
55
517-527
2006
Homo sapiens
Butovich, I.A.; Lukyanova, S.M.; Bachmann, C.
Dihydroxydocosahexaenoic acids of the neuroprotectin D family: synthesis, structure, and inhibition of human 5-lipoxygenase
J. Lipid Res.
47
2462-2474
2006
Homo sapiens
Araico, A.; Terencio, M.C.; Alcaraz, M.J.; Dominguez, J.N.; Leon, C.; Ferrandiz, M.L.
Phenylsulphonyl urenyl chalcone derivatives as dual inhibitors of cyclo-oxygenase-2 and 5-lipoxygenase
Life Sci.
78
2911-2918
2006
Homo sapiens
Chen, T.; Shiao, M.; Pan, B.S.
Inhibition of 12- and 15-lipoxygenase activities and protection of human and tilapia low density lipoprotein oxidation by I-Tiao-Gung (Glycine tomentella)
Lipids
40
1171-1177
2005
Oreochromis niloticus
Poeckel, D.; Niedermeyer, T.H.; Pham, H.T.; Mikolasch, A.; Mundt, S.; Lindequist, U.; Lalk, M.; Werz, O.
Inhibition of human 5-lipoxygenase and anti-neoplastic effects by 2-amino-1,4-benzoquinones
Med. Chem.
2
591-595
2006
Homo sapiens
Rakonjac, M.; Fischer, L.; Provost, P.; Werz, O.; Steinhilber, D.; Samuelsson, B.; Radmark, O.
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production
Proc. Natl. Acad. Sci. USA
103
13150-13155
2006
Homo sapiens
Raghavenra, H.; Diwakr, B.T.; Lokesh, B.R.; Naidu, K.A.
Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells
Prostaglandins Leukot. Essent. Fatty Acids
74
23-27
2006
Homo sapiens
Frum, Y.; Viljoen, A.M.
In vitro 5-lipoxygenase and anti-oxidant activities of South African medicinal plants commonly used topically for skin diseases
Skin Pharmacol. Physiol.
19
329-335
2006
Homo sapiens
Pufahl, R.A.; Kasten, T.P.; Hills, R.; Gierse, J.K.; Reitz, B.A.; Weinberg, R.A.; Masferrer, J.L.
Development of a fluorescence-based enzyme assay of human 5-lipoxygenase
Anal. Biochem.
364
204-212
2007
Homo sapiens
Mahesha, H.G.; Singh, S.A.; Rao, A.G.
Inhibition of lipoxygenase by soy isoflavones: evidence of isoflavones as redox inhibitors
Arch. Biochem. Biophys.
461
176-185
2007
Homo sapiens
Huang, L.S.; Kim, M.R.; Jeong, T.S.; Sok, D.E.
Linoleoyl lysophosphatidic acid and linoleoyl lysophosphatidylcholine are efficient substrates for mammalian lipoxygenases
Biochim. Biophys. Acta
1770
1062-1070
2007
Solanum tuberosum
Zheng, M.; Zheng, M.; Ye, D.; Deng, Y.; Qiu, S.; Luo, X.; Chen, K.; Liu, H.; Jiang, H.
Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling
Bioorg. Med. Chem. Lett.
17
2414-2420
2007
Rattus norvegicus (P12527)
Belfiore, M.C.; Natoni, A.; Barzellotti, R.; Merendino, N.; Pessina, G.; Ghibelli, L.; Gualandi, G.
Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells
Cancer Lett.
254
236-243
2007
Homo sapiens
Gonzalez-Periz, A.; Claria, J.
New approaches to the modulation of the cyclooxygenase-2 and 5-lipoxygenase pathways
Curr. Top. Med. Chem.
7
297-309
2007
Homo sapiens
Gubitosi-Klug, R.A.; Talahalli, R.; Du, Y.; Nadler, J.L.; Kern, T.S.
5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy
Diabetes
57
1387-1393
2008
Mus musculus, Mus musculus C57BL/6
Scholz, M.; Ulbrich, H.K.; Dannhardt, G.
Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles
Eur. J. Med. Chem.
43
1152-1159
2008
Bos taurus
Adamek, A.; Jung, S.; Dienesch, C.; Laser, M.; Ertl, G.; Bauersachs, J.; Frantz, S.
Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice
Eur. J. Pharmacol.
571
51-54
2007
Mus musculus (P48999)
Herb, F.; Thye, T.; Niemann, S.; Browne, E.N.; Chinbuah, M.A.; Gyapong, J.; Osei, I.; Owusu-Dabo, E.; Werz, O.; Ruesch-Gerdes, S.; Horstmann, R.D.; Meyer, C.G.
ALOX5 variants associated with susceptibility to human pulmonary tuberculosis
Hum. Mol. Genet.
17
1052-1060
2008
Homo sapiens
Cook-Moreau, J.M.; El-Makhour Hojeij, Y.; Barriere, G.; Rabinovitch-Chable, H.C.; Faucher, K.S.; Sturtz, F.G.; Rigaud, M.A.
Expression of 5-lipoxygenase (5-LOX) in T lymphocytes
Immunology
122
157-166
2007
Homo sapiens
Huang, L.S.; Kim, M.R.; Sok, D.E.
Regulation of lipoxygenase activity by polyunsaturated lysophosphatidylcholines or their oxygenation derivatives
J. Agric. Food Chem.
56
7808-7814
2008
Solanum tuberosum
Ezekwudo, D.E.; Wang, R.C.; Elegbede, J.A.
Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway
J. Exp. Ther. Oncol.
6
267-277
2007
Homo sapiens
Lopez-Parra, M.; Titos, E.; Horrillo, R.; Ferre, N.; Gonzalez-Periz, A.; Martinez-Clemente, M.; Planaguma, A.; Masferrer, J.L.; Arroyo, V.; Claria, J.
Regulatory effects of arachidonate 5-lipoxygenase on hepatic MTP activity and VLDL-TG and ApoB secretion in obese mice
J. Lipid Res.
49
2513-2523
2008
Mus musculus (P48999), Mus musculus, Mus musculus C57/BL6J (P48999)
Franke, L.; Schwarz, O.; Mueller-Kuhrt, L.; Hoernig, C.; Fischer, L.; George, S.; Tanrikulu, Y.; Schneider, P.; Werz, O.; Steinhilber, D.; Schneider, G.
Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening
J. Med. Chem.
50
2640-2646
2007
Homo sapiens
Massi, P.; Valenti, M.; Vaccani, A.; Gasperi, V.; Perletti, G.; Marras, E.; Fezza, F.; Maccarrone, M.; Parolaro, D.
5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid
J. Neurochem.
104
1091-1100
2008
Homo sapiens, Hordeum vulgare
Vincent, C.; Fiancette, R.; Donnard, M.; Bordessoule, D.; Turlure, P.; Trimoreau, F.; Denizot, Y.
5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts
Leuk. Res.
32
1756-1762
2008
Homo sapiens
Chinnici, C.M.; Yao, Y.; Pratico, D.
The 5-lipoxygenase enzymatic pathway in the mouse brain: Young versus old
Neurobiol. Aging
28
1457-1462
2007
Mus musculus (P48999), Mus musculus, Mus musculus C57BL/6 (P48999)
Sudina, G.F.; Pushkareva, M.A.; Shephard, P.; Klein, T.
Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors
Prostaglandins Leukot. Essent. Fatty Acids
78
99-108
2008
Homo sapiens
Loetzer, K.; Jahn, S.; Kramer, C.; Hildner, M.; Nuesing, R.; Funk, C.D.; Habenicht, A.J.
5-Lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells
Prostaglandins Other Lipid Mediat.
84
108-115
2007
Homo sapiens
Michel, A.A.; Steinhilber, D.; Werz, O.
Development of a method for expression and purification of the regulatory C2-like domain of human 5-lipoxygenase
Protein Expr. Purif.
59
110-116
2008
Homo sapiens
Radmark, O.; Werz, O.; Steinhilber, D.; Samuelsson, B.
5-Lipoxygenase: regulation of expression and enzyme activity
Trends Biochem. Sci.
32
332-341
2007
Mus musculus, Rattus norvegicus, Homo sapiens (P09917)
Koeberle, A.; Zettl, H.; Greiner, C.; Wurglics, M.; Schubert-Zsilavecz, M.; Werz, O.
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase
J. Med. Chem.
51
8068-8076
2008
Homo sapiens
Strid, T.; Svartz, J.; Franck, N.; Hallin, E.; Ingelsson, B.; Soederstroem, M.; Hammarstroem, S.
Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein
Biochem. Biophys. Res. Commun.
381
518-522
2009
Homo sapiens
Macdonald, D.; Brideau, C.; Chan, C.C.; Falgueyret, J.P.; Frenette, R.; Guay, J.; Hutchinson, J.H.; Perrier, H.; Prasit, P.; Riendeau, D.; Tagari, P.; Therien, M.; Young, R.N.; Girard, Y.
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein
Bioorg. Med. Chem. Lett.
18
2023-2027
2008
Homo sapiens
Doiron, J.; Boudreau, L.H.; Picot, N.; Villebonet, B.; Surette, M.E.; Touaibia, M.
Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters
Bioorg. Med. Chem. Lett.
19
1118-1121
2009
Homo sapiens
Reddy, M.V.; Billa, V.K.; Pallela, V.R.; Mallireddigari, M.R.; Boominathan, R.; Gabriel, J.L.; Reddy, E.P.
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors
Bioorg. Med. Chem.
16
3907-3916
2008
Oryctolagus cuniculus, Homo sapiens
Mahshid, Y.; Lisy, M.; Wang, X.; Spanbroek, R.; Flygare, J.; Christensson, B.; Bjoerkholm, M.; Sander, B.; Habenicht, A.; Claesson, H.
High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes
BMC Immunol.
10
2-2
2009
Homo sapiens
Borges, C.L.; Cecchini, R.; Tatakihara, V.L.; Malvezi, A.D.; Yamada-Ogatta, S.F.; Rizzo, L.V.; Pinge-Filho, P.
5-Lipoxygenase plays a role in the control of parasite burden and contributes to oxidative damage of erythrocytes in murine Chagas disease
Immunol. Lett.
123
38-45
2009
Mus musculus
Jian, W.; Lee, S.H.; Williams, M.V.; Blair, I.A.
5-Lipoxygenase-mediated endogenous DNA damage
J. Biol. Chem.
284
16799-16807
2009
Homo sapiens
Aparoy, P.; Reddy, R.N.; Guruprasad, L.; Reddy, M.R.; Reddanna, P.
Homology modeling of 5-lipoxygenase and hints for better inhibitor design
J. Comput. Aided Mol. Des.
22
611-619
2008
Solanum tuberosum
Radmark, O.; Samuelsson, B.
5-Lipoxygenase: mechanisms of regulation
J. Lipid Res.
50 Suppl
S40-S45
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Chowdhury, M.A.; Abdellatif, K.R.; Dong, Y.; Das, D.; Suresh, M.R.; Knaus, E.E.
Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity
J. Med. Chem.
52
1525-1529
2009
Solanum tuberosum
Karg, E.M.; Luderer, S.; Pergola, C.; Buehring, U.; Rossi, A.; Northoff, H.; Sautebin, L.; Troschuetz, R.; Werz, O.
Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase
J. Med. Chem.
52
3474-3483
2009
Homo sapiens, Rattus norvegicus
Liedtke, A.J.; Keck, P.R.; Lehmann, F.; Koeberle, A.; Werz, O.; Laufer, S.A.
Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX)
J. Med. Chem.
52
4968-4972
2009
Homo sapiens
Knaup, B.; Oehme, A.; Valotis, A.; Schreier, P.
Anthocyanins as lipoxygenase inhibitors
Mol. Nutr. Food Res.
53
617-624
2009
Homo sapiens
Leifert, W.; Abeywardena, M.
Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity
Nutr. Res.
28
729-737
2008
Glycine max
Chen, S.H.; Fahmi, H.; Shi, Q.; Benderdour, M.
Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes
Arthritis Res. Ther.
12
R21
2010
Homo sapiens
Choi, J.H.; Jeon, H.J.; Park, J.G.; Sonn, S.K.; Lee, M.R.; Lee, M.N.; You, H.J.; Kim, G.Y.; Kim, J.H.; Lee, M.H.; Kwon, O.S.; Nam, K.H.; Kim, H.C.; Jeong, T.S.; Lee, W.S.; Oh, G.T.
Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice
Atherosclerosis
212
146-152
2010
Mus musculus
Radmark, O.; Samuelsson, B.
Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis
Biochem. Biophys. Res. Commun.
396
105-110
2010
Homo sapiens
Esser, J.; Rakonjac, M.; Hofmann, B.; Fischer, L.; Provost, P.; Schneider, G.; Steinhilber, D.; Samuelsson, B.; Radmark, O.
Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: Role of tryptophan 102
Biochem. J.
425
265-274
2010
Homo sapiens
Katryniok, C.; Schnur, N.; Gillis, A.; von Knethen, A.; Sorg, B.; Looijenga, L.; Radmark, O.; Steinhilber, D.
Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity
Biochim. Biophys. Acta
1801
49-57
2010
Homo sapiens
Aparoy, P.; Kumar Reddy, K.; Kalangi, S.K.; Chandramohan Reddy, T.; Reddanna, P.
Pharmacophore modeling and virtual screening for designing potential 5-lipoxygenase inhibitors
Bioorg. Med. Chem. Lett.
20
1013-1018
2010
Solanum tuberosum
Yu, G.; Praveen Rao, P.N.; Chowdhury, M.A.; Abdellatif, K.R.; Dong, Y.; Das, D.; Velazquez, C.A.; Suresh, M.R.; Knaus, E.E.
Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase
Bioorg. Med. Chem. Lett.
20
2168-2173
2010
Solanum tuberosum
Yu, G.; Chowdhury, M.A.; Abdellatif, K.R.; Dong, Y.; Praveen Rao, P.N.; Das, D.; Velazquez, C.A.; Suresh, M.R.; Knaus, E.E.
Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity
Bioorg. Med. Chem. Lett.
20
896-902
2010
Solanum tuberosum
Fischer, A.S.; Metzner, J.; Steinbrink, S.D.; Ulrich, S.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Maier, T.J.
5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity
Br. J. Pharmacol.
161
936-949
2010
Homo sapiens
Shin, V.Y.; Jin, H.C.; Ng, E.K.; Sung, J.J.; Chu, K.M.; Cho, C.H.
Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth
Cancer Lett.
292
237-245
2010
Homo sapiens
Steinbrink, S.D.; Pergola, C.; Buehring, U.; George, S.; Metzner, J.; Fischer, A.S.; Haefner, A.K.; Wisniewska, J.M.; Geisslinger, G.; Werz, O.; Steinhilber, D.; Maier, T.J.
Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations
Cell. Mol. Life Sci.
67
797-806
2010
Homo sapiens
Marruchella, G.; Giacominelli-Stuffler, R.; Baffoni, M.; Maccarrone, M.
5-Lipoxygenase and cyclooxygenase-2 in porcine parasitic bronchopneumonia: immunohistochemical and biochemical investigations
J. Comp. Pathol.
142
139-146
2010
Sus scrofa
Radmark, O.; Samuelsson, B.
Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer
J. Intern. Med.
268
5-14
2010
Homo sapiens
Pavanelli, W.R.; Gutierrez, F.R.; Mariano, F.S.; Prado, C.M.; Ferreira, B.R.; Teixeira, M.M.; Canetti, C.; Rossi, M.A.; Cunha, F.Q.; Silva, J.S.
5-Lipoxygenase is a key determinant of acute myocardial inflammation and mortality during Trypanosoma cruzi infection
Microbes Infect.
12
587-597
2010
Mus musculus
Cho, Y.S.; Kim, C.H.; Surh, J.H.; Kang, N.S.; Yoo, S.E.; Cheon, H.G.
Identification of 4-[4-(4-fluoro-phenyl)-thiazol-2-ylamino]-2,6-dimethyl-phenol (KR-33749) as an inhibitor of 5-lipoxygenase with potent antiinflammatory activity
Pharmacology
86
65-72
2010
Rattus norvegicus
Kim, C.E.; Lee, S.J.; Seo, K.W.; Park, H.M.; Yun, J.W.; Bae, J.U.; Bae, S.S.; Kim, C.D.
Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway
Toxicol. Appl. Pharmacol.
245
76-82
2010
Mus musculus
Walther, M.; Hofheinz, K.; Vogel, R.; Roffeis, J.; Kuehn, H.
The N-terminal beta-barrel domain of mammalian lipoxygenases including mouse 5-lipoxygenase is not essential for catalytic activity and membrane binding but exhibits regulatory functions
Arch. Biochem. Biophys.
516
1-9
2011
Mus musculus
Chen, Y.P.; Zhang, Z.Y.; Li, Y.P.; Li, D.; Huang, S.L.; Gu, L.Q.; Xu, J.; Huang, Z.S.
Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase
Eur. J. Med. Chem.
66
22-31
2013
Solanum tuberosum
Filosa, R.; Peduto, A.; Aparoy, P.; Schaible, A.M.; Luderer, S.; Krauth, V.; Petronzi, C.; Massa, A.; de Rosa, M.; Reddanna, P.; Werz, O.
Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase
Eur. J. Med. Chem.
67
269-279
2013
Homo sapiens
Hofmann, B.; Barzen, S.; Roedl, C.B.; Kiehl, A.; Borig, J.; Zivkovic, A.; Stark, H.; Schneider, G.; Steinhilber, D.
A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors
J. Med. Chem.
54
1943-1947
2011
Homo sapiens
Khairullina, V.; Taipov, I.; Gerchikov, A.; Zarudii, F.
Structure-activity relationship in a series of natural and synthetic inhibitors of 5-lipoxygenase catalytic activity
Pharm. Chem. J.
46
553-564
2012
Rattus norvegicus
-
Kretschmer, S.B.M; Woltersdorf, S.; Vogt, D.; Lillich, F.F.; Ruehl, M.; Karas, M.; Maucher, I.V.; Roos, J.; Haefner, A.-K.; Kaiser, A.; Wurglics, M.; Schubert-Zsilavecz, M.; Angioni, C.; Geisslinger, G.; Stark, H.; Steinhilber, D.; Hofmann, B.
Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles
Biochem. Pharmacol.
123
52-62
2017
Homo sapiens (P09917), Homo sapiens
Khayrullina, V.R.; Taipov, I.A.; Veselovsky, A.V.; Shcherbinin, D.S.; Gerchikov, A.Y.
New inhibitors of 5-lipoxygenase catalytic activity based on 2-(3-methylphenyl)propanoic acid and 4-substituted morpholine derivatives
Biochemistry (Moscow)
79
376-384
2014
Homo sapiens (P09917)
Smyrniotis, C.J.; Barbour, S.R.; Xia, Z.; Hixon, M.S.; Holman, T.R.
ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid
Biochemistry
53
4407-4419
2014
Homo sapiens (P09917), Homo sapiens
Mitra, S.; Bartlett, S.G.; Newcomer, M.E.
Identification of the substrate access portal of 5-lipoxygenase
Biochemistry
54
6333-6342
2015
Homo sapiens (P09917)
Schroeder, M.; Haefner, A.K.; Hofmann, B.; Radmark, O.; Tumulka, F.; Abele, R.; Doetsch, V.; Steinhilber, D.
Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase
Biochim. Biophys. Acta
1842
1538-1547
2014
Homo sapiens (P09917), Homo sapiens
Haefner, A.K.; Gerstmeier, J.; Hoernig, M.; George, S.; Ball, A.K.; Schroeder, M.; Garscha, U.; Werz, O.; Steinhilber, D.
Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP
Biochim. Biophys. Acta
1851
1465-1472
2015
Homo sapiens (P09917), Homo sapiens
Ball, A.K.; Beilstein, K.; Wittmann, S.; Sueruen, D.; Saul, M.J.; Schnuetgen, F.; Flamand, N.; Capelo, R.; Kahnt, A.S.; Frey, H.; Schaefer, L.; Marschalek, R.; Haefner, A.K.; Steinhilber, D.
Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LODELTA13, 5-LODELTA4 and 5-LOp12
Biochim. Biophys. Acta
1862
561-571
2017
Homo sapiens (P09917), Homo sapiens
Shang, E.; Liu, Y.; Wu, Y.; Zhu, W
; He, C.; Lai, L. Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors
Bioorg. Med. Chem.
22
2396-2402
2014
Homo sapiens (P09917), Homo sapiens
Mittal, M.; Kumar, R.B.; Balagunaseelan, N.; Hamberg, M.; Jegerschoeld, C.; Radmark, O.; Haeggstroem, J.Z.; Rinaldo-Matthis, A.
Kinetic investigation of human 5-lipoxygenase with arachidonic acid
Bioorg. Med. Chem. Lett.
26
3547-3551
2016
Homo sapiens (P09917), Homo sapiens
Torras, J.; Maccarrone, M.; Dainese, E.
Molecular dynamics study on the apo- and holo-forms of 5-lipoxygenase
Biotechnol. Appl. Biochem.
65
54-61
2017
Homo sapiens (P09917)
Pergola, C.; Gerstmeier, J.; Moench, B.; Caliskan, B.; Luderer, S.; Weinigel, C.; Barz, D.; Maczewsky, J.; Pace, S.; Rossi, A.; Sautebin, L.; Banoglu, E.; Werz, O.
The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP)
Br. J. Pharmacol.
171
3051-3064
2014
Homo sapiens (P09917)
Wang, T.; Zuo, R.; Mai, K.; Xu, W.; Ai, Q.
Molecular cloning and functional characterization of arachidonate 5-lipoxygenase (Alox5), and its expression in response to the ratio of linolenic acid to linoleic acid in diets of large yellow croaker (Larmichthys crocea)
Comp. Biochem. Physiol. B
201
21-28
2016
Larimichthys crocea (A0A075C1I3), Larimichthys crocea
Peduto, A.; Scuotto, M.; Krauth, V.; Roviezzo, F.; Rossi, A.; Temml, V.; Esposito, V.; Stuppner, H.; Schuster, D.; D'Agostino, B.; Schiraldi, C.; de Rosa, M.; Werz, O.; Filosa, R.
Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase
Eur. J. Med. Chem.
127
715-726
2017
Homo sapiens (P09917), Homo sapiens
Peduto, A.; Bruno, F.; Dehm, F.; Krauth, V.; de Caprariis, P.; Weinigel, C.; Barz, D.; Massa, A.; De Rosa, M.; Werz, O.; Filosa, R.
Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase
Eur. J. Med. Chem.
81
492-498
2014
Homo sapiens (P09917), Homo sapiens
Ho, X.L.; Liu, J.J.; Loke, W.M.
Plant sterol-enriched soy milk consumption modulates 5-lipoxygenase, 12-lipoxygenase, and myeloperoxidase activities in healthy adults - a randomized-controlled trial
Free Radic. Res.
50
1396-1407
2016
Homo sapiens (P09917)
Schieferdecker, S.; Koenig, S.; Koeberle, A.; Dahse, H.-M.; Werz, O.; Nett, M.
Myxochelins target human 5-lipoxygenase
J. Nat. Prod.
78
335-338
2015
Homo sapiens (P09917), Homo sapiens
Meirer, K.; Glatzel, D.; Kretschmer, S.; Wittmann, S.K.; Hartmann, M.; Bloecher, R.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Hofmann, B.; Fuerst, R.; Proschak, E.
Design, synthesis and cellular characterization of a dual inhibitor of 5-lipoxygenase and soluble epoxide hydrolase
Molecules
22
45
2016
Homo sapiens (P09917)
Chagas-Paula, D.A.; Oliveira, T.B.; Faleiro, D.P.V.; Oliveira, R.B.; Da Costa, F.B.
Outstanding anti-inflammatory potential of selected Asteraceae species through the potent dual inhibition of cyclooxygenase-1 and 5-lipoxygenase
Planta Med.
81
1296-1307
2015
Homo sapiens (P09917)
Allain, E.P.; Boudreau, L.H.; Flamand, N.; Surette, M.E.
The Intracellular localisation and phosphorylation profile of the human 5-lipoxygenase DELTA13 isoform differs from that of its full length counterpart
PLoS ONE
10
e0132607
2015
Homo sapiens (P09917), Homo sapiens
Haefner, A.K.; Beilstein, K.; Graab, P.; Ball, A.K.; Saul, M.J.; Hofmann, B.; Steinhilber, D.
Identification and characterization of a new protein isoform of human 5-lipoxygenase
PLoS ONE
11
e0166591
2016
Homo sapiens (P09917), Homo sapiens
Nandha, B.; Ramareddy, S.A.; Kuntal, H.
Synthesis of substituted fluorobenzimidazoles as inhibitors of 5-lipoxygenase and soluble epoxide hydrolase for anti-inflammatory activity
Arch. Pharm.
351
e1800030
2018
Glycine max
Maucher, I.V.; Ruehl, M.; Kretschmer, S.B.; Hofmann, B.; Kuehn, B.; Fettel, J.; Vogel, A.; Fluegel, K.T.; Manolikakes, G.; Hellmuth, N.; Haefner, A.K.; Golghalyani, V.; Ball, A.K.; Piesche, M.; Matrone, C.; Geisslinger, G.; Parnham, M.J.; Karas, M.; Steinhilber, D.; Roos, J.; Maier, T.J.
Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418
Biochem. Pharmacol.
125
55-74
2017
Homo sapiens (P09917), Homo sapiens
Green, A.R.; Freedman, C.; Tena, J.; Tourdot, B.E.; Liu, B.; Holinstat, M.; Holman, T.R.
5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a lipoxin intermediate Reactivity and kinetics with human leukocyte 5-lipoxygenase, platelet 12-lipoxygenase, and reticulocyte 15-lipoxygenase-1
Biochemistry
57
6726-6734
2018
Homo sapiens (P09917), Homo sapiens
Perry, S.C.; Horn, T.; Tourdot, B.E.; Yamaguchi, A.; Kalyanaraman, C.; Conrad, W.S.; Akinkugbe, O.; Holinstat, M.; Jacobson, M.P.; Holman, T.R.
Role of human 15-lipoxygenase-2 in the biosynthesis of the lipoxin intermediate, 5S,15S-diHpETE, implicated with the altered positional specificity of human 15-lipoxygenase-1
Biochemistry
59
4118-4130
2020
Homo sapiens (P09917)
El-Nagar, M.K.S.; Abdu-Allah, H.H.M.; Salem, O.I.A.; Kafafy, A.N.; Farghaly, H.S.M.
Novel N-substituted 5-aminosalicylamides as dual inhibitors of cyclooxygenase and 5-lipoxygenase enzymes Synthesis, biological evaluation and docking study
Bioorg. Chem.
78
80-93
2018
Solanum tuberosum
Doiron, J.A.; Leblanc, L.M.; Hebert, M.J.; Levesque, N.A.; Pare, A.F.; Jean-Francois, J.; Cormier, M.; Surette, M.E.; Touaibia, M.
Structure-activity relationship of caffeic acid phenethyl ester analogs as new 5-lipoxygenase inhibitors
Chem. Biol. Drug Des.
89
514-528
2017
Homo sapiens (P09917)
Selka, A.; Doiron, J.A.; Lyons, P.; Dastous, S.; Chiasson, A.; Cormier, M.; Turcotte, S.; Surette, M.E.; Touaibia, M.
Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells
Eur. J. Med. Chem.
179
347-357
2019
Homo sapiens (P09917)
Dinh, C.P.; Ville, A.; Neukirch, K.; Viault, G.; Temml, V.; Koeberle, A.; Werz, O.; Schuster, D.; Stuppner, H.; Richomme, P.; Helesbeux, J.J.; Seraphin, D.
Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors
Eur. J. Med. Chem.
202
112518
2020
Homo sapiens (P09917), Homo sapiens
Echeverria, J.; Urzua, A.
Inhibition of soybean 15-lipoxygenase and human 5-lipoxygenase by extracts of leaves, stem bark, phenols and catechols isolated from Lithraea caustica (Anacardiaceae)
Front. Pharmacol.
11
594257
2020
Homo sapiens (P09917), Homo sapiens
Roy, P.; Faye, D.; Blanchard, S.; Cormier, M.; Doiron, J.; Surette, M.; Touaibia, M.
New caffeic acid phenylethyl ester analogs bearing substituted triazole Synthesis and structure-activity relationship study towards 5-lipoxygenase inhibition
J. Chem.
2017
2380531
2017
Homo sapiens (P09917)
-
Phillips, O.A.; Bosso, M.A.; Ezeamuzie, C.I.
Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors
J. Enzyme Inhib. Med. Chem.
35
1471-1482
2020
Homo sapiens (P09917), Homo sapiens
Hiesinger, K.; Kramer, J.S.; Beyer, S.; Eckes, T.; Brunst, S.; Flauaus, C.; Wittmann, S.K.; Weizel, L.; Kaiser, A.; Kretschmer, S.B.M.; George, S.; Angioni, C.; Heering, J.; Geisslinger, G.; Schubert-Zsilavecz, M.; Schmidtko, A.; Pogoryelov, D.; Pfeilschifter, J.; Hofmann, B.; Steinhilber, D.; Sch, S.c.h.w.
Design, synthesis, and structure-activity relationship studies of dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase
J. Med. Chem.
63
11498-11521
2020
Homo sapiens (P09917), Homo sapiens
Park, N.Y.; Im, S.; Jiang, Q.
Different forms of vitamin E and metabolite 13-carboxychromanols inhibit cyclooxygenase-1 and its catalyzed thromboxane in platelets, and tocotrienols and 13-carboxychromanols are competitive inhibitors of 5-lipoxygenase
J. Nutr. Biochem.
100
108884
2022
Homo sapiens (P09917)
Gilbert, N.C.; Gerstmeier, J.; Schexnaydre, E.E.; Boerner, F.; Garscha, U.; Neau, D.B.; Werz, O.; Newcomer, M.E.
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products
Nat. Chem. Biol.
16
783-790
2020
Homo sapiens (P09917), Homo sapiens
Munoz-Osses, M.; Quiroz, J.; Vasquez-Martixadnez, Y.; Flores, E.; Navarrete, E.; Godoy, F.; Torrent, C.; Cortez-San Martin, M.; Gomez, A.; Mascayano, C.
Evaluation of cyrhetrenyl and ferrocenyl precursors as 5-lipoxygenase inhibitors - biological and computational studies
New J. Chem.
45
13360-13368
2021
Homo sapiens (P09917)
-
Mbarik, M.; Poirier, S.; Doiron, J.; Selka, A.; Barnett, D.; Cormier, M.; Touaibia, M.; Surette, M.
Phenolic acid phenethylesters and their corresponding ketones Inhibition of 5-lipoxygenase and stability in human blood and HepaRG cells
Pharmacol. Res. Perspect.
7
e00524
2019
Homo sapiens (P09917), Homo sapiens
html completed
