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BRENDA support

Information on EC 1.13.11.45 - linoleate 11-lipoxygenase

for references in articles please use BRENDA:EC1.13.11.45

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IUBMB Comments

The product (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate, is converted, more slowly, into (9Z,11E)-(13R)-13-hydroperoxyoctadeca-9,11-dienoate. The enzyme from the fungus Gaeumannomyces graminis requires Mn2+. It also acts on α-linolenate, whereas γ-linolenate is a poor substrate. Oleate and arachidonate are not substrates.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
lipoxygenase 2, manganese lipoxygenase, mn-lo, mnlox, csplox2, 13r-mnlox, fo-mnlox, mo-mnlox, mn-lox, cg-mnlox, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
linoleate + O2 = (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
Highest Expressing Human Cell Lines
Cell Line Links Gene Links