Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 1.14.11.2 - procollagen-proline 4-dioxygenase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pihlajaniemi, T.; Helaakoski, T.; Tasanen, K.; Myllylä, R.; Huhtala, M.L.; Koivu, J.; Kivirikko, K.I.
Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulfide isomerase are products of the same gene
EMBO J.
6
643-649
1987
Homo sapiens
Manually annotated by BRENDA team
Kivirikko, K.I.; Myllylä, R.
The hydroxylation of prolyl and lysyl residues
Enzymol. Post- transl. Modif. Proteins (Freedman, R. B. , Hawkins, H. C. , eds. ) Academic Press, New York
1
53-104
1980
Gallus gallus, Homo sapiens, Rattus norvegicus
-
Manually annotated by BRENDA team
Kivirikko, K.I.; Myllylä, R.
Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes
Methods Enzymol.
82
245-304
1982
Gallus gallus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Guzman, N.A.; Ascari, W.Q.; Cutroneo, K.R.; Desnick, R.J.
Comparison between avian and human prolyl 4-hydroxylases: studies on the holomeric enzymes and their constituent subunits
J. Cell. Biochem.
48
172-189
1992
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Kivirikko, K.I.; Myllylä, R.; Pihlajaniemi, T.
Protein hydroxylation: prolyl 4-hydroxylase, an enzyme with four cosubstrates and a multifunctional subunit
FASEB J.
3
1609-1617
1989
Gallus gallus, Homo sapiens, Mus musculus, Volvox carteri
Manually annotated by BRENDA team
De Waal, A.; de Jong, L.
Processive action of the two peptide binding sites of prolyl 4-hydroxylase in the hydroxylation of procollagen
Biochemistry
27
150-155
1988
Gallus gallus
Manually annotated by BRENDA team
De Waal, A.; Hartog, A.F.; de Jong, L.
Localisation and quantification of the 2-oxoglutarate binding sites of prolyl 4-hydroxylase by photoaffinity labeling with tritiated 5-azidopyridine-2-carboxylic acid
Biochim. Biophys. Acta
953
20-25
1988
Gallus gallus
-
Manually annotated by BRENDA team
Gunzler, V.; Brocks, D.; Henke, S.; Myllylä, R.; Geiger, R.; Kivirikko, K.I.
Syncatalytic inactivation of prolyl 4-hydroxylase by synthetic peptides containing the unphysiologic amino acid 5-oxaproline
J. Biol. Chem.
263
19498-19504
1988
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Gunzler, V.; Hanauske-Abel, H.M.; Myllylä, R.; Kaska, D.D.; Hanauske, A.; Kivirikko, K.I.
Syncatalytic inactivation of prolyl 4-hydroxylase by anthracyclines
Biochem. J.
251
365-372
1988
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Gunzler, V.; Hanauske-Abel, H.M.; Myllylä, R.; Mohr, J.; Kivirikko, K.I.
Time-dependent inactivation of chick-embryo prolyl 4-hydroxylase by coumalic acid. Evidence for a syncatalytic mechanism
Biochem. J.
242
163-169
1987
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Kivirikko, K.I.; Myllylä, R.
Recent developments in posttranslational modification: intracellular processing
Methods Enzymol.
144
96-114
1987
Gallus gallus, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Marumo, K.; Waite, J.H.
Prolyl 4-hydroxylase in the foot of the marine mussel Mytilus edulis L.: Purification and characterization
J. Exp. Zool.
244
365-374
1987
Mytilus edulis
Manually annotated by BRENDA team
Cunliffe, C.J.; Franklin, T.J.
Inhibition of prolyl 4-hydroxylase by hydroxyanthraquinones
Biochem. J.
239
311-315
1986
Gallus gallus
Manually annotated by BRENDA team
Atreya, P.L.; Ananthanarayanan, V.S.
Interaction of prolyl 4-hydroxylase with synthetic peptide substrates. A conformational model for collagen proline hydroxylation
J. Biol. Chem.
266
2852-2858
1991
Gallus gallus
Manually annotated by BRENDA team
Hussain, M.Z.; Ghani, Q.P.; Hunt, T.K.
Inhibition of prolyl hydroxylase by poly(ADP-ribose) and phosphoribosyl-AMP. Possible role of ADP-ribosylation in intracellular prolyl hydroxylase regulation
J. Biol. Chem.
264
7850-7855
1989
Gallus gallus
Manually annotated by BRENDA team
Kedersha, N.L.; Tkacz, J.S.; Berg, R.A.
Characterization of the oligosaccharides of prolyl hydroxylase, a microsomal glycoprotein
Biochemistry
24
5952-5960
1985
Gallus gallus
Manually annotated by BRENDA team
De Jong, L.; Kemp, A.
Stoicheiometry and kinetics of the prolyl 4-hydroxylase partial reaction
Biochim. Biophys. Acta
787
105-111
1984
Gallus gallus
Manually annotated by BRENDA team
Majamaa, K.; Hanauske-Abel, H.M.; Gunzler, V.; Kivirikko, K.I.
The 2-oxoglutarate binding site of prolyl 4-hydroxylase. Identification of distinct subsites and evidence for 2-oxoglutarate decarboxylation in a ligand reaction at the enzyme-bound ferrous ion
Eur. J. Biochem.
138
239-245
1984
Gallus gallus
Manually annotated by BRENDA team
Majamaa, K.; Gunzler, V.; Hanauske-Abel, H.M.; Myllylä, R.; Kivirikko, K.I.
Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase
J. Biol. Chem.
261
7819-7823
1986
Gallus gallus
Manually annotated by BRENDA team
De Jong, L.; Albracht, S.P.J.; Kemp., A.
Prolyl 4-hydroxylase activity in relation to the oxidation state of enzyme-bound iron. The role of ascorbate in peptidyl proline hydroxylation
Biochim. Biophys. Acta
704
326-332
1982
Gallus gallus
Manually annotated by BRENDA team
Nietfeld, J.J.; Kemp, A.
Properties of prolyl 4-hydroxylase containing firmly-bound iron
Biochim. Biophys. Acta
613
349-358
1980
Gallus gallus
Manually annotated by BRENDA team
De Jong, L.; van der Kraan, I.; de Waal, A.
The kinetics of the hydroxylation of procollagen by prolyl 4-hydroxylase. Proposal for a processive mechanism of binding of the dimeric hydroxylating enzyme in relation to the high kcat/Km ratio and a conformational requirement for hydroxylation of -X-Pro-Gly- sequences
Biochim. Biophys. Acta
1079
103-111
1991
Gallus gallus
Manually annotated by BRENDA team
Takeda, K.; Katoh, F.; Kawai, S.; Konno, K.
Stimulation of prolyl hydroxylase activity by chelating agents
Arch. Biochem. Biophys.
197
273-276
1979
Rattus norvegicus
Manually annotated by BRENDA team
Berg, R.A.; Kedersha, N.L.; Guzman, N.A.
Purification and partial characterization of the two nonidentical subunits of prolyl hydroxylase
J. Biol. Chem.
254
3111-3118
1979
Gallus gallus
Manually annotated by BRENDA team
Tryggvason, K.; Majamaa, K.; Kivirikko, K.I.
Prolyl 3-hydroxylase and 4-hydroxylase activities in certain rat and chick-embryo tissues and age-related changes in their activities in the rat
Biochem. J.
178
127-131
1979
Gallus gallus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Tryggvason, K.; Risteli, J.; Kivirikko, K.I.
Separation of prolyl 3-hydroxylase and 4-hydroxylase activities and the 4-hydroxyproline requirement for synthesis of 3-hydroxyproline
Biochem. Biophys. Res. Commun.
76
275-281
1977
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Leushner, J.R.A.; Pasternak, J.
Partial purification and characterization of prolyl hydroxylase from the free-living nematode Panagrellus silusiae
Can. J. Zool.
56
159-165
1978
Panagrellus silusiae
-
Manually annotated by BRENDA team
Tuderman, L.; Oikarinen, A.; Kivirikko, K.I.
Tetramers and monomers of prolyl hydroxylase in isolated chick-embryo tendon cells. The association of inactive monomers to active tetramers and a preliminary characterization of the intracellular monomer-size protein
Eur. J. Biochem.
78
547-556
1977
Gallus gallus
Manually annotated by BRENDA team
Tuderman, L.; Myllylä, R.; Kivirikko, K.I.
Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates
Eur. J. Biochem.
80
341-348
1977
Gallus gallus
Manually annotated by BRENDA team
Myllylä, R.; Tuderman, L.; Kivirikko, K.I.
Mechanism of the prolyl hydroxylase reaction. 2. Kinetic analysis of the reaction sequence
Eur. J. Biochem.
80
349-357
1977
Gallus gallus
Manually annotated by BRENDA team
Guzman, N.A.; Berg.R.A.; Prockop, D.J.
Concanavalin A binds of purified prolyl hydroxylase and partially inhibits its enzymic activity
Biochem. Biophys. Res. Commun.
73
279-285
1976
Gallus gallus
Manually annotated by BRENDA team
Risteli, J.; Tuderman, L.; Kivirikko, K.I.
Intracellular enzymes of collagen biosynthesis in rat liver as a function of age and in hepatic injury induced by dimethylnitrosamine. Purification of rat prolyl hydroxylase and comparison of changes in prolyl hydroxylase activity with changes in immunoreactive prolyl hydroxylase
Biochem. J.
158
369-376
1976
Rattus norvegicus
Manually annotated by BRENDA team
Rapaka, R.S.; Sorensen, K.R.; Lee, S.D.; Bhatnagar, R.S.
Inhibition of hydroxyproline synthesis by palladium ions
Biochim. Biophys. Acta
429
63-71
1976
Gallus gallus
Manually annotated by BRENDA team
Tuderman, L.; Kuutti, E.R.; Kivirikko, K.I.
An affinity-column procedure using poly(L-proline) for the purification of prolyl hydroxylase. Purification of the enzyme from chick embryos
Eur. J. Biochem.
52
9-16
1975
Gallus gallus
Manually annotated by BRENDA team
Kuutti, L.R.; Tuderman, L.; Kivirikko, K.I.
Human prolyl hydroxylase. Purification, partial characterization and preparation of antiserum to the enzyme
Eur. J. Biochem.
57
181-188
1975
Homo sapiens
Manually annotated by BRENDA team
Berg, R.A.; Prockop, D.J.
Affinity column purification of protocollagen proline hydroxylase from chick embryos and further characterization of the enzyme
J. Biol. Chem.
248
1175-1182
1973
Gallus gallus
Manually annotated by BRENDA team
McGee, J.O'D.; Udenfriend, S.
Partial purification and characterization of peptidyl proline hydroxylase precursor from mouse fibroblasts
Arch. Biochem. Biophys.
152
216-221
1972
Mus musculus
Manually annotated by BRENDA team
Kivirikko, K.I.; Kishida, Y.; Sakakibara, S.; Prockop, D.J.
Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase. Effect of chain length, helical conformation and amino acid sequence in the substrate
Biochim. Biophys. Acta
271
347-356
1972
Gallus gallus
Manually annotated by BRENDA team
Kivirikko, K.I.; Prockop, D.J.
Purification and partial characterization of the enzyme for the hydroxylation of proline in protocollagen
Arch. Biochem. Biophys.
118
611-618
1967
Gallus gallus
-
Manually annotated by BRENDA team
Bolwell, G.P.; Robbins, M.P.; Dixon, R.A.
Elicitor-induced prolyl hydroxylase from French bean (Phaseolus vulgaris). Localization, purification and properties
Biochem. J.
229
693-699
1985
Phaseolus vulgaris
Manually annotated by BRENDA team
Kaska, D.D.; Gunzler, V.; Kivirikko, K.I.; Myllylä, R.
Characterization of a low-relative-molecular-mass prolyl 4-hydroxylase from the green alga Chlamydomonas reinhardii
Biochem. J.
241
483-490
1987
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Blankenstein, P.; Lang, W.C.; Robinson, D.G.
Isolation and characterization of prolyl hydroxylase from Chlamydomonas reinhardii
Planta
169
238-244
1986
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Chrispeels, M.J.
Prolyl hydroxylase in plants
Methods Enzymol.
107
361-369
1984
Catharanthus roseus, Daucus carota, Lolium multiflorum
-
Manually annotated by BRENDA team
Tanaka, M.; Shibata, H.; Uchida, T.
A new prolyl hydroxylase acting on poly-L-proline, from suspension cultured cells of Vinca rosea
Biochim. Biophys. Acta
616
188-198
1980
Catharanthus roseus
Manually annotated by BRENDA team
Kaska, D.D.; Myllylä, R.; Gunzler, V.; Gibori, A.; Kivirikko, K.I.
Prolyl 4-hydroxylase from Volvox carteri. A low-Mr enzyme antigenically related to the alpha subunit of the vertebrate enzyme
Biochem. J.
256
257-263
1988
Persea americana, Ulva intestinalis, Helianthus tuberosus, Volvox carteri
Manually annotated by BRENDA team
Kuttan, R.; Radhakrishnan, A.N.
Biochemistry of the hydroxyprolines
Adv. Enzymol. Relat. Areas Mol. Biol.
37
273-347
1973
Daucus carota
Manually annotated by BRENDA team
Adams, E.; Lamon, M.
Prolyl hydroxylase of earthworms. Substrate specificity of an enzyme from the subcuticular epithelium
J. Biol. Chem.
252
7591-7597
1977
Lumbricus terrestris, Rattus norvegicus
Manually annotated by BRENDA team
Koivu, J.; Myllylä, R.
Protein disulfide-isomerase retains procollagen prolyl 4-hydroxylase structure in its native conformation
Biochemistry
25
5982-5986
1986
Gallus gallus
Manually annotated by BRENDA team
Hutton, J.J.; Tappel, A.L.; Udenfried, S.
Cofactor and substrate requirements of collagen proline hydroxylase
Arch. Biochem. Biophys.
118
231-240
1967
Cavia porcellus, Gallus gallus, Rattus norvegicus
-
Manually annotated by BRENDA team
De Waal, A.; de Jong, L.; Hartog, A.F.; Kemp, A.
Photoaffinity labeling of peptide binding sites of prolyl 4-hydroxylase with N-(4-azido-2-nitrophenyl)glycyl-(Pro-Pro-Gly)5
Biochemistry
24
6493-6499
1985
Gallus gallus
Manually annotated by BRENDA team
De Waal, A.; Hartog, A.F.; de Jong, L.
Photoaffinity labeling of the 2-oxoglutarate binding site of prolyl 4-hydroxylase with 5-azidopyridine-2-carboxylic acid
Biochim. Biophys. Acta
912
151-155
1987
Gallus gallus
Manually annotated by BRENDA team
Turpeenniemi-Hujanen, T.; Myllylä, R.
Concomitant hydroxylation of proline and lysine residues in collagen using purified enzymes in vitro
Biochim. Biophys. Acta
800
59-65
1984
Gallus gallus
Manually annotated by BRENDA team
Cain, G.D.; Fairbairn, D.
Protocollagen proline hydroxylase and collagen synthesis in developing eggs of Ascaris lumbricoides
Comp. Biochem. Physiol. B
40
165-179
1971
Ascaris lumbricoides
Manually annotated by BRENDA team
Guzman, N.A.; Oronsky, A.L.; Suarez, G.; Meyerson, L.R.; Cutroneo, K.R.; Olsen, B.R.; Prockop, D.J.
Prolyl 4-hydroxylase from human placenta. Simultaneous isolation of immunoglobulin G which binds to Ascaris cuticle collagen
Coll. Relat. Res.
2
365-380
1982
Gallus gallus
-
Manually annotated by BRENDA team
Cohen, P.B.; Schibeci, A.; Fincher, G.B.
Biosynthesis of arabinogalactan-protein in Lolium multiflorum (ryegrass) endosperm cells. III. Subcellular distribution of prolyl hydroxylase
Plant Physiol.
72
754-758
1983
Lolium multiflorum
Manually annotated by BRENDA team
Rao, N.V.; Adams, E.
Purification and properties of proline hydroxylase from earthworm subcuticular epithelium
Fed. Proc.
33
1535
1974
Lumbricus terrestris
-
Manually annotated by BRENDA team
Helaakoski, T.; Vuori, K.; Myllyla, R.; Kivirikko, K.I.; Pihlajaniemi, T.
Molecular cloning of the a-subunit of human prolyl 4-hydroxylase: the complete cDNA-derived amino acid sequence and evidence for alternative splicing of RNA transcripts
Proc. Natl. Acad. Sci. USA
86
4392-4396
1989
Homo sapiens
Manually annotated by BRENDA team
Berg, R.A.; Prockop, D.J.
Purification of (14C)-protocollagen and its hydroxylation by prolyl-hydroxylase
Biochemistry
12
3395-3401
1973
Gallus gallus
Manually annotated by BRENDA team
Veijola, J.; Koivunen, P.; Annunen, P.; Pihlajaniemi, T.; Kivirikko, K.I.
Cloning, baculovirus expression, and characterization of the a subunit of prolyl 4-hydroxylase from the nematode Caenorhabditis elegans. This a subunit forms an active ab dimer with the human protein disulfide isomerase/b subunit
J. Biol. Chem.
269
26746-26753
1994
Caenorhabditis elegans
Manually annotated by BRENDA team
Baader, E.; Tschank, G.; Baringhaus, K.H.; Burghard, H.; Guenzler, V.
Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues
Biochem. J.
300
525-530
1994
Gallus gallus
-
Manually annotated by BRENDA team
Lamberg, A.; Pihlajaniemi, T.; Kivirikko, K.I.
Site-directed mutagenesis of the a subunit of human prolyl 4-hydroxylase. Identification of three histidine residues critical for catalytic activity
J. Biol. Chem.
270
9926-9931
1995
Homo sapiens
Manually annotated by BRENDA team
Helaakoski, T.; Annunen, P.; Vuori, K.; MacNeil, I.A.; Pihlajaniemi, T.; Kivirikko, K.I.
Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase a-subunit isoform: formation of an a2b2 tetramer with the protein disulfide-isomerase/b subunit
Proc. Natl. Acad. Sci. USA
92
4427-4431
1995
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Lawrence, C.C.; Sobey, W.J.; Field, R.A.; Baldwin, J.E.; Schofield, C.J.
Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridis P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis
Biochem. J.
313
185-191
1996
Streptomyces griseoviridis
-
Manually annotated by BRENDA team
Mazzorana, M.; Snellman, A.; Kivirikko, K.I.; van der Rest, M.; Pihlajaniemi, T.
Involvement of prolyl 4-hydroxylase in the assembly of trimeric minicollagen XII. Study in baculovirus expression system
J. Biol. Chem.
271
29003-29008
1996
Homo sapiens
Manually annotated by BRENDA team
Annunen, P.; Helaakoski, T.; Myllyharju, J.; Veijola, J.; Pihlajaniemi, T.; Kivirikko, K.I.
Cloning of the human prolyl 4-hydroxylase a subunit isoform a(II) and characterization of the type II enzyme tetramer. The a(I) and a(II) subunits do not form a mixed a(I)a(II)b2 tetramer
J. Biol. Chem.
272
17342-17348
1997
Gallus gallus, Homo sapiens (O15460), Homo sapiens
Manually annotated by BRENDA team
Annunen, P.; Autio-Harmainen, H.; Kivirikko, K.I.
The novel type II prolyl 4-hydroxylase is the main enzyme form in chondrocytes and capillary endothelial cells, whereas the type I enzyme predominates in most cells
J. Biol. Chem.
273
5989-5992
1998
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Wojtaszek, P.; Smith, C.G.; Bolwell, G.P.
Ultrastructural localization and further biochemical characterization of prolyl 4-hydroxylase from Phaseolus vulgaris: comparative analysis
Int. J. Biochem. Cell Biol.
31
463-477
1999
Phaseolus vulgaris, Tropaeolum majus
Manually annotated by BRENDA team
Annunen, P.; Koivunen, P.; Kivirikko, K.I.
Cloning of the a subunit of prolyl 4-hydroxylase from Drosophila and expression and characterization of the corresponding enzyme tetramer with some unique properties
J. Biol. Chem.
274
6790-6796
1999
Drosophila melanogaster, Homo sapiens
Manually annotated by BRENDA team
Eriksson, M.; Myllyharju, J.; Tu, H.; Hellman, M.; Kivirikko, K.I.
Evidence for 4-hydroxyproline in viral proteins. Characterization of a viral prolyl 4-hydroxylase and its peptide substrates
J. Biol. Chem.
274
22131-22134
1999
Paramecium bursaria Chlorella virus 1
Manually annotated by BRENDA team
Franklin, T.J.; Morris, W.P.; Edwards, P.N.; Large, M.S.; Stephenson, R.
Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones
Biochem. J.
353
333-338
2001
Gallus gallus, Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Merriweather, A.; Guenzler, V.; Brenner, M.; Unnasch, T.R.
Characterization and expression of enzymatically active recombinant filarial prolyl 4-hydroxylase
Mol. Biochem. Parasitol.
116
185-197
2001
Brugia malayi, Onchocerca volvulus (Q95W51), Onchocerca volvulus (Q95W53), Onchocerca volvulus
Manually annotated by BRENDA team
Ko, M.K.; Kay, E.P.
Subcellular localization of procollagen I and prolyl 4-hydroxylase in corneal endothelial cells
Exp. Cell Res.
264
363-371
2001
Oryctolagus cuniculus
Manually annotated by BRENDA team
Hieta, R.; Myllyharju, J.
Cloning and characterization of a low molecular weight prolyl 4-hydroxylase from Arabidopsis thaliana. Effective hydroxylation of proline-rich, collagen-like, and hypoxia-inducible transcription factor a-like peptides
J. Biol. Chem.
277
23965-23971
2002
Arabidopsis thaliana, Arabidopsis thaliana (Q8L970), Arabidopsis thaliana (Q8LAN3), Arabidopsis thaliana (Q9ZW86)
Manually annotated by BRENDA team
ekkala, M.; Hieta, R.; Kursula, P.; Kivirikko, K.I.; Wierenga, R.K.; Myllyharju, J.
Crystallization of the proline-rich-peptide binding domain of human type I collagen prolyl 4-hydroxylase
Acta Crystallogr. Sect. D
59
940-942
2003
Homo sapiens
Manually annotated by BRENDA team
Nissi, R.; Bohling, T.; Autio-Harmainen, H.
Immunofluorescence localization of prolyl 4-hydroxylase isoenzymes and type I and II collagens in bone tumours: type I enzyme predominates in osteosarcomas and chondrosarcomas, whereas type II enzyme predominates in their benign counterparts
Acta Histochem.
106
111-121
2004
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Petersen, L.; Olewinski, R.; Salmon, P.; Connors, N.
Novel proline hydroxylase activities in the pneumocandin-producing fungus Glarea lozoyensis responsible for the formation of trans 3- and trans 4-hydroxyproline
Appl. Microbiol. Biotechnol.
62
263-267
2003
Glarea lozoyensis
Manually annotated by BRENDA team
Hofbauer, K.h.; Gess, B.; Lohaus, C.; Meyer, H.E.; Katschinski, D.; Kurtz, A.
Oxygen tension regulates the expression of a group of procollagen hydroxylases
Eur. J. Biochem.
270
4515-4522
2003
Rattus norvegicus, Rattus norvegicus (P54001)
Manually annotated by BRENDA team
Tuckerman, J.R.; Zhao, Y.; Hewitson, K.S.; Tian, Y.M.; Pugh, C.W.; Ratcliffe, P.J.; Mole, D.R.
Determination and comparison of specific activity of the HIF-prolyl hydroxylases
FEBS Lett.
576
145-150
2004
Homo sapiens, Homo sapiens (Q96KS0), Homo sapiens (Q9H6Z9)
Manually annotated by BRENDA team
Hirsila, M.; Koivunen, P.; Gunzler, V.; Kivirikko, K.I.; Myllyharju, J.
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
J. Biol. Chem.
278
30772-30780
2003
Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9)
Manually annotated by BRENDA team
Hieta, R.; Kukkola, L.; Permi, P.; Pirilae, P.; Kivirikko, K.I.; Kilpelaeinen, I.; Myllyharju, J.
The peptide-substrate-binding domain of human collagen prolyl 4-hydroxylases: backbone assignments, secondary structure, and binding of proline-rich peptides
J. Biol. Chem.
278
34966-34974
2003
Homo sapiens
Manually annotated by BRENDA team
Kukkola, L.; Hieta, R.; Kivirikko, K.I.; Myllyharju, J.
Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme
J. Biol. Chem.
278
47685-47693
2003
Rattus norvegicus (Q6W3E9), Mus musculus (Q6W3F0), Mus musculus, Homo sapiens (Q7Z4N8), Homo sapiens
Manually annotated by BRENDA team
Kukkola, L.; Koivunen, P.; Pakkanen, O.; Page, A.P.; Myllyharju, J.
Collagen prolyl 4-hydroxylase tetramers and dimers show identical decreases in Km values for peptide substrates with increasing chain length: mutation of one of the two catalytic sites in the tetramer inactivates the enzyme by more than half
J. Biol. Chem.
279
18656-18661
2004
Caenorhabditis elegans
Manually annotated by BRENDA team
Tiainen, P.; Myllyharju, J.; Koivunen, P.
Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity
J. Biol. Chem.
280
1142-1148
2005
Arabidopsis thaliana
Manually annotated by BRENDA team
Myllyharju, J.
Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis
Matrix Biol.
22
15-24
2003
Arabidopsis thaliana, Drosophila melanogaster, Paramecium bursaria Chlorella virus-1, Homo sapiens (O15460), Homo sapiens (P13674), Caenorhabditis elegans (Q20065)
Manually annotated by BRENDA team
Kersteen, E.A.; Higgin, J.J.; Raines, R.T.
Production of human prolyl 4-hydroxylase in Escherichia coli
Protein Expr. Purif.
38
279-291
2004
Homo sapiens
Manually annotated by BRENDA team
Li, N.; Yi, F.; Sundy, C.M.; Chen, L.; Hilliker, M.L.; Donley, D.K.; Muldoon, D.B.; Li, P.L.
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys
Am. J. Physiol. Renal Physiol.
292
F207-F216
2007
Rattus norvegicus
Manually annotated by BRENDA team
Li, H.C.; Huang, C.C.; Chen, S.F.; Chou, M.Y.
Assembly of homotrimeric type XXI minicollagen by coexpression of prolyl 4-hydroxylase in stably transfected Drosophila melanogaster S2 cells
Biochem. Biophys. Res. Commun.
336
375-385
2005
Homo sapiens
Manually annotated by BRENDA team
Tian, Y.M.; Mole, D.R.; Ratcliffe, P.J.; Gleadle, J.M.
Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation
Biochem. J.
397
179-186
2006
Homo sapiens
Manually annotated by BRENDA team
Cervera, A.M.; Apostolova, N.; Luna-Crespo, F.; Sanjuan-Pla, A.; Garcia-Bou, R.; McCreath, K.J.
An alternatively spliced transcript of the PHD3 gene retains prolyl hydroxylase activity
Cancer Lett.
233
131-138
2006
Homo sapiens
Manually annotated by BRENDA team
Callapina, M.; Zhou, J.; Schnitzer, S.; Metzen, E.; Lohr, C.; Deitmer, J.W.; Bruene, B.
Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron
Exp. Cell Res.
306
274-284
2005
Homo sapiens
Manually annotated by BRENDA team
van der Wel, H.; Ercan, A.; West, C.M.
The Skp1 prolyl hydroxylase from Dictyostelium is related to the hypoxia-inducible factor-alpha class of animal prolyl 4-hydroxylases
J. Biol. Chem.
280
14645-14655
2005
Dictyostelium discoideum (Q86KR9), Dictyostelium discoideum AX3 (Q86KR9)
Manually annotated by BRENDA team
Chen, L.; Shen, Y.H.; Wang, X.; Wang, J.; Gan, Y.; Chen, N.; Wang, J.; LeMaire, S.A.; Coselli, J.S.; Wang, X.L.
Human prolyl-4-hydroxylase alpha(I) transcription is mediated by upstream stimulatory factors
J. Biol. Chem.
281
10849-10855
2006
Homo sapiens
Manually annotated by BRENDA team
Neubauer, A.; Soini, J.; Bollok, M.; Zenker, M.; Sandqvist, J.; Myllyharju, J.; Neubauer, P.
Fermentation process for tetrameric human collagen prolyl 4-hydroxylase in Escherichia coli: improvement by gene optimisation of the PDI/beta subunit and repeated addition of the inducer anhydrotetracycline
J. Biotechnol.
128
308-321
2007
Homo sapiens
Manually annotated by BRENDA team
Neubauer, A.; Neubauer, P.; Myllyharju, J.
High-level production of human collagen prolyl 4-hydroxylase in Escherichia coli
Matrix Biol.
24
59-68
2005
Homo sapiens
Manually annotated by BRENDA team
Choi, K.O.; Lee, T.; Lee, N.; Kim, J.H.; Yang, E.G.; Yoon, J.M.; Kim, J.H.; Lee, T.G.; Park, H.
Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger
Mol. Pharmacol.
68
1803-1809
2005
Homo sapiens
Manually annotated by BRENDA team
Yuasa, K.; Toyooka, K.; Fukuda, H.; Matsuoka, K.
Membrane-anchored prolyl hydroxylase with an export signal from the endoplasmic reticulum
Plant J.
41
81-94
2005
Nicotiana tabacum
Manually annotated by BRENDA team
Cummins, E.P.; Berra, E.; Comerford, K.M.; Ginouves, A.; Fitzgerald, K.T.; Seeballuck, F.; Godson, C.; Nielsen, J.E.; Moynagh, P.; Pouyssegur, J.; Taylor, C.T.
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity
Proc. Natl. Acad. Sci. USA
103
18154-18159
2006
Homo sapiens
Manually annotated by BRENDA team
McDonough, M.A.; Li, V.; Flashman, E.; Chowdhury, R.; Mohr, C.; Lienard, B.M.; Zondlo, J.; Oldham, N.J.; Clifton, I.J.; Lewis, J.; McNeill, L.A.; Kurzeja, R.J.; Hewitson, K.S.; Yang, E.; Jordan, S.; Syed, R.S.; Schofield, C.J.
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
Proc. Natl. Acad. Sci. USA
103
9814-9819
2006
Homo sapiens
Manually annotated by BRENDA team
Meng, L.; Huang, M.; Ye, X.; Fan, M.; Bian, Z.
Increased expression of collagen prolyl 4-hydroxylases in Chinese patients with hereditary gingival fibromatosis
Arch. Oral Biol.
52
1209-1214
2007
Homo sapiens
Manually annotated by BRENDA team
Cho, E.S.; Jung, W.Y.; Kwon, E.J.; Park, D.H.; Chung, K.H.; Cho, K.K.; Kim, C.W.
Cloning and Expression Analysis of the ?-Subunit of Porcine Prolyl 4-hydroxylase.
Asian-Australas. J. Anim. Sci.
20
1655-1661
2007
Sus scrofa
Manually annotated by BRENDA team
Imaoka, S.; Muraguchi, T.; Kinoshita, T.
Isolation of Xenopus HIF-prolyl 4-hydroxylase and rescue of a small-eye phenotype caused by Siah2 over-expression
Biochem. Biophys. Res. Commun.
355
419-425
2007
Xenopus laevis (Q6DFD1)
Manually annotated by BRENDA team
Villar, D.; Vara-Vega, A.; Landazuri, M.O.; Del Peso, L.
Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains
Biochem. J.
408
231-240
2007
Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9)
Manually annotated by BRENDA team
Gorres, K.L.; Edupuganti, R.; Krow, G.R.; Raines, R.T.
Conformational preferences of substrates for human prolyl 4-hydroxylase
Biochemistry
47
9447-9455
2008
Homo sapiens
Manually annotated by BRENDA team
Zhang, C.; Zhang, M.; Shen, Y.H.; Burks, J.K.; Li, X.; LeMaire, S.A.; Yoshimura, K.; Aoki, H.; Matsuzaki, M.; An, F.; Engler, D.A.; Matsunami, R.K.; Coselli, J.S.; Zhang, Y.; Wang, X.L.
Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha 1
Biochim. Biophys. Acta
1783
1517-1528
2008
Homo sapiens
Manually annotated by BRENDA team
West, C.M.; van der Wel, H.; Wang, Z.A.
Prolyl 4-hydroxylase-1 mediates O2 signaling during development of Dictyostelium
Development
134
3349-3358
2007
Dictyostelium discoideum
Manually annotated by BRENDA team
Choi, H.J.; Soh, Y.
An assay method for screening inhibitors of prolyl 4-hydroxylase in immortalized rat hepatic stellate HSC-T6 cells
J. Appl. Pharmacol.
15
261-265
2007
Rattus norvegicus
-
Manually annotated by BRENDA team
Koivunen, P.; Tiainen, P.; Hyvaerinen, J.; Williams, K.E.; Sormunen, R.; Klaus, S.J.; Kivirikko, K.I.; Myllyharju, J.
An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha
J. Biol. Chem.
282
30544-30552
2007
Homo sapiens
Manually annotated by BRENDA team
Koski, M.K.; Hieta, R.; Boellner, C.; Kivirikko, K.I.; Myllyharju, J.; Wierenga, R.K.
The active site of an algal prolyl 4-hydroxylase has a large structural plasticity
J. Biol. Chem.
282
37112-37123
2007
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Keskiaho, K.; Kukkola, L.; Page, A.P.; Winter, A.D.; Vuoristo, J.; Sormunen, R.; Nissi, R.; Riihimaa, P.; Myllyharju, J.
Characterization of a novel Caenorhabditis elegans prolyl 4-hydroxylase with a unique substrate specificity and restricted expression in the pharynx and excretory duct
J. Biol. Chem.
283
10679-10689
2008
Caenorhabditis elegans
Manually annotated by BRENDA team
Keskiaho, K.; Hieta, R.; Sormunen, R.; Myllyharju, J.
Chlamydomonas reinhardtii has multiple prolyl 4-hydroxylases, one of which is essential for proper cell wall assembly
Plant Cell
19
256-269
2007
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Leite, R.B.; Brito, A.B.; Cancela, M.L.
An oxygen molecular sensor, the HIF prolyl 4-hydroxylase, in the marine protist Perkinsus olseni
Protist
159
355-368
2008
Perkinsus olseni (A7LD83)
Manually annotated by BRENDA team
Miller, M.A.; Scott, E.E.; Limburg, J.
Expression, purification, crystallization and preliminary X-ray studies of a prolyl-4-hydroxylase protein from Bacillus anthracis
Acta Crystallogr. Sect. F
64
788-791
2008
Bacillus anthracis
Manually annotated by BRENDA team
Gorres, K.L.; Raines, R.T.
Direct and continuous assay for prolyl 4-hydroxylase
Anal. Biochem.
386
181-185
2009
Homo sapiens
Manually annotated by BRENDA team
Myllyharju, J.
Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets
Ann. Med.
40
402-417
2008
Caenorhabditis elegans, Chlamydomonas reinhardtii, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Stein, H.; Wilensky, M.; Tsafrir, Y.; Rosenthal, M.; Amir, R.; Avraham, T.; Ofir, K.; Dgany, O.; Yayon, A.; Shoseyov, O.
Production of bioactive, post-translationally modified, heterotrimeric, human recombinant type-I collagen in transgenic tobacco
Biomacromolecules
10
2640-2645
2009
Homo sapiens
Manually annotated by BRENDA team
Koski, M.K.; Hieta, R.; Hirsilae, M.; Roenkae, A.; Myllyharju, J.; Wierenga, R.K.
The crystal structure of an algal prolyl 4-hydroxylase complexed with a proline-rich peptide reveals a novel buried tripeptide binding motif
J. Biol. Chem.
284
25290-25301
2009
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Qi, H.H.; Ongusaha, P.P.; Myllyharju, J.; Cheng, D.; Pakkanen, O.; Shi, Y.; Lee, S.W.; Peng, J.; Shi, Y.
Prolyl 4-hydroxylation regulates Argonaute 2 stability
Nature
455
421-424
2008
Homo sapiens
Manually annotated by BRENDA team
Gorres, K.L.; Pua, K.H.; Raines, R.T.
Stringency of the 2-His-1-Asp active-site motif in prolyl 4-hydroxylase
PLoS ONE
4
e7635
2009
Homo sapiens
Manually annotated by BRENDA team
Chowdhury, R.; McDonough, M.A.; Mecinovic, J.; Loenarz, C.; Flashman, E.; Hewitson, K.S.; Domene, C.; Schofield, C.J.
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Structure
17
981-989
2009
Homo sapiens
Manually annotated by BRENDA team
Liu, Y.; Huo, Z.; Yan, B.; Lin, X.; Zhou, Z.N.; Liang, X.; Zhu, W.; Liang, D.; Li, L.; Liu, Y.; Zhao, H.; Sun, Y.; Chen, Y.H.
Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells
Biochem. Biophys. Res. Commun.
401
231-237
2010
Rattus norvegicus
Manually annotated by BRENDA team
Culpepper, M.; Scott, E.; Limburg, J.
Crystal structure of prolyl 4-hydroxylase from Bacillus anthracis
Biochemistry
49
124-133
2010
Bacillus anthracis (Q81LZ8), Bacillus anthracis
Manually annotated by BRENDA team
Xue, J.; Li, X.; Jiao, S.; Wei, Y.; Wu, G.; Fang, J.
Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity
Gastroenterology
138
606-615
2010
Homo sapiens
Manually annotated by BRENDA team
Vogel, S.; Wottawa, M.; Farhat, K.; Zieseniss, A.; Schnelle, M.; Le-Huu, S.; von Ahlen, M.; Malz, C.; Camenisch, G.; Katschinski, D.M.
Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation
J. Biol. Chem.
285
33756-33763
2010
Homo sapiens
Manually annotated by BRENDA team
Fu, J.; Taubman, M.B.
Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathway
J. Biol. Chem.
285
8927-8935
2010
Rattus norvegicus
Manually annotated by BRENDA team
Tennant, D.A.; Gottlieb, E.
HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression
J. Mol. Med.
88
839-849
2010
Homo sapiens
Manually annotated by BRENDA team
Spinella, F.; Rosano, L.; Del Duca, M.; Di Castro, V.; Nicotra, M.R.; Natali, P.G.; Bagnato, A.
Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells
PLoS ONE
5
e11241
2010
Homo sapiens
Manually annotated by BRENDA team
Pektas, S.; Knapp, M.J.
Substrate preference of the HIF-prolyl hydroxylase-2 (PHD2) and substrate-induced conformational change
J. Inorg. Biochem.
126
55-60
2013
Homo sapiens
Manually annotated by BRENDA team
Yum, S.; Choi, J.; Hong, S.; Park, M.H.; Lee, J.; Ha, N.C.; Jung, Y.
Hyperoxia attenuates the inhibitory effect of nitric oxide donors on HIF prolyl-4-hydroxylase-2: Implication on discriminative effect of nitric oxide on HIF prolyl-4-hydroxylase-2 and collagen prolyl-4-hydroxylase
Biochem. Pharmacol.
82
485-490
2011
Homo sapiens
Manually annotated by BRENDA team
Vasta, J.D.; Higgin, J.J.; Kersteen, E.A.; Raines, R.T.
Bioavailable affinity label for collagen prolyl 4-hydroxylase
Bioorg. Med. Chem.
21
3597-3601
2013
Caenorhabditis elegans, Homo sapiens
Manually annotated by BRENDA team
Munemasa, N.; Suyama, A.; Matsuoka, K.
Role of lumenal domain on intracellular localization of tobacco membrane-anchored prolyl 4-hydroxylase
Biosci. Biotechnol. Biochem.
76
2159-2161
2012
Nicotiana tabacum
Manually annotated by BRENDA team
Zhang, D.; van der Wel, H.; Johnson, J.M.; West, C.M.
Skp1 prolyl 4-hydroxylase of Dictyostelium mediates glycosylation-independent and -dependent responses to O2 without affecting Skp1 stability
J. Biol. Chem.
287
2006-2016
2012
Dictyostelium discoideum
Manually annotated by BRENDA team
Song, D.; Li, L.S.; Heaton-Johnson, K.J.; Arsenault, P.R.; Master, S.R.; Lee, F.S.
Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway
J. Biol. Chem.
288
9662-9674
2013
Homo sapiens
Manually annotated by BRENDA team
Chen, R.L.; Nagel, S.; Papadakis, M.; Bishop, T.; Pollard, P.; Ratcliffe, P.J.; Pugh, C.W.; Buchan, A.M.
Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice
J. Physiol.
590
4079-4091
2012
Mus musculus
Manually annotated by BRENDA team
Duran, R.V.; MacKenzie, E.D.; Boulahbel, H.; Frezza, C.; Heiserich, L.; Tardito, S.; Bussolati, O.; Rocha, S.; Hall, M.N.; Gottlieb, E.
HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
Oncogene
32
4549-4556
2013
Homo sapiens
Manually annotated by BRENDA team
Schnicker, N.; Dey, M.
Structural analysis of cofactor binding for a prolyl 4-hydroxylase from the pathogenic bacterium Bacillus anthracis
Acta Crystallogr. Sect. D
72
675-681
2016
Bacillus anthracis (Q81LZ8), Bacillus anthracis
Manually annotated by BRENDA team
Xiong, G.; Deng, L.; Zhu, J.; Rychahou, P.G.; Xu, R.
Prolyl-4-hydroxylase alpha subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition
BMC Cancer
14
1-1
2014
Homo sapiens (O15460)
Manually annotated by BRENDA team
Cao, X.Q.; Liu, X.X.; Li, M.M.; Zhang, Y.; Chen, L.; Wang, L.; Di, M.X.; Zhang, M.
Overexpression of prolyl-4-hydroxylase-alpha1 stabilizes but increases shear stress-induced atherosclerotic plaque in apolipoprotein E-deficient mice
Dis. Markers
2016
1701637
2016
Mus musculus (Q60715), Mus musculus ApoE (Q60715)
Manually annotated by BRENDA team
Huang, X.; Liu, X.; Song, J.; Wang, L.; Liu, X.; Qu, H.; Wang, S.; Zhang, C.; Zhang, Y.; Zhang, M.
Prolyl-4-hydroxylase-alpha1 improves the stability of advanced plaques but accelerates the atherosclerotic lesion formation of early plaques
Eur. Heart J.
17
C49-C58
2015
Mus musculus (Q60715)
-
Manually annotated by BRENDA team
Liu, X.; Huang, X.; Chen, L.; Zhang, Y.; Li, M.; Wang, L.; Ge, C.; Wang, H.; Zhang, M.
Mechanical stretch promotes matrix metalloproteinase-2 and prolyl-4-hydroxylase alpha1 production in human aortic smooth muscle cells via Akt-p38 MAPK-JNK signaling
Int. J. Biochem. Cell Biol.
62
15-23
2015
Homo sapiens (P13674), Homo sapiens, Rattus norvegicus (P54001), Rattus norvegicus Wistar (P54001)
Manually annotated by BRENDA team
Timmins, A.; Saint-Andre, M.; de Visser, S.P.
Understanding how prolyl-4-hydroxylase structure steers a ferryl oxidant toward scission of a strong C-H bond
J. Am. Chem. Soc.
139
9855-9866
2017
Homo sapiens (P13674), Homo sapiens
Manually annotated by BRENDA team
Schnicker, N.; Dey, M.
Bacillus anthracis prolyl 4-hydroxylase modifies collagen-like substrates in asymmetric patterns
J. Biol. Chem.
291
13360-13374
2016
Bacillus anthracis (Q81LZ8), Bacillus anthracis
Manually annotated by BRENDA team
Shi, R.; Gao, S.; Zhang, J.; Xu, J.; Graham, L.; Yang, X.; Li, C.
Collagen prolyl 4-hydroxylases modify tumor progression
Acta Biochim. Biophys. Sin. (Shanghai)
53
805-814
2021
Homo sapiens (O15460), Homo sapiens (P13674), Homo sapiens (Q7Z4N8)
Manually annotated by BRENDA team
Song, W.; Yang, C.; Zhu, C.; Morris, P.; Zhang, X.
Crystal structure and expression patterns of prolyl 4-hydroxylases from Phytophthora capsici
Biochem. Biophys. Res. Commun.
508
1011-1017
2019
Phytophthora capsici (A0A4P1LYH8), Mus musculus (Q60715), Mus musculus (Q60716), Mus musculus, Phytophthora capsici LT1534 (A0A4P1LYH8)
Manually annotated by BRENDA team
Vasta, J.D.; Choudhary, A.; Jensen, K.H.; McGrath, N.A.; Raines, R.T.
Prolyl 4-hydroxylase substrate isosteres in which an (E)- or (Z)-alkene replaces the prolyl peptide bond
Biochemistry
56
219-227
2017
Chlamydomonas reinhardtii (A8IDI8), Chlamydomonas reinhardtii, Homo sapiens (P13674), Homo sapiens
Manually annotated by BRENDA team
Schnicker, N.J.; Razzaghi, M.; Guha Thakurta, S.; Chakravarthy, S.; Dey, M.
Bacillus anthracis prolyl 4-hydroxylase interacts with and modifies elongation factor Tu
Biochemistry
56
5771-5785
2017
Bacillus anthracis (A0A4Y1WAP5), Bacillus anthracis
Manually annotated by BRENDA team
Rong, H.; Zhang, Y.; Hao, M.; Zou, W.; Yu, J.; Yu, C.; Shi, Q.; Wen, X.
Effects of dietary hydroxyproline on collagen metabolism, proline 4-hydroxylase activity, and expression of related gene in swim bladder of juvenile Nibea diacanthus
Fish Physiol. Biochem.
45
1779-1790
2019
Protonibea diacanthus
Manually annotated by BRENDA team
Konkina, A.; Klepadlo, M.; Lakehal, A.; Zein, Z.E.; Krokida, A.; Botros, M.; Iakovidis, M.; Chernobavskiy, P.; Elfatih Zerroumda, M.; Tsanakas, G.; Petrakis, N.; Dourou, A.M.; Kalaitzis, P.
An Arabidopsis prolyl 4-hydroxylase is involved in the low oxygen response
Front. Plant Sci.
12
637352
2021
Arabidopsis thaliana (Q9LN20)
Manually annotated by BRENDA team
Vasta, J.D.; Raines, R.T.
Collagen prolyl 4-hydroxylase as a therapeutic target
J. Med. Chem.
61
10403-10411
2018
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Xiong, G.; Stewart, R.L.; Chen, J.; Gao, T.; Scott, T.L.; Samayoa, L.M.; OConnor, K.; Lane, A.N.; Xu, R.
Collagen prolyl 4-hydroxylase 1 is essential for HIF-1alpha stabilization and TNBC chemoresistance
Nat. Commun.
9
4456
2018
Homo sapiens (P13674), Homo sapiens
Manually annotated by BRENDA team
Shi, J.; Ma, X.; Gao, Y.; Fan, D.; Zhu, C.; Mi, Y.; Xue, W.
Hydroxylation of human type III collagen alpha chain by recombinant coexpression with a viral prolyl 4-hydroxylase in Escherichia coli
Protein J.
36
322-331
2017
Paramecium bursaria Chlorella virus 1 (Q84406)
Manually annotated by BRENDA team
Murthy, A.V.; Sulu, R.; Koski, M.K.; Tu, H.; Anantharajan, J.; Sah-Teli, S.K.; Myllyharju, J.; Wierenga, R.K.
Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II) High affinity peptides have a PxGP sequence motif
Protein Sci.
27
1692-1703
2018
Homo sapiens (O15460), Homo sapiens
Manually annotated by BRENDA team