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deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2
reaction mechanism
-
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2
reaction mechanism
-
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2
reaction mechanism
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2
first reaction: catalyses three separate oxidative reactions in the pathway for the biosynthesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC 3.5.3.22, proclavaminate amidinohydrolase. The three reactions are all catalysed at the same nonheme iron site
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-
-
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2
this reaction is due to a proclavaminate amidinohydrolase PAH, gene cla
-
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2
once the oxoferryl species is formed, the oxidative cyclization most likely involves either a mechanism involving C4'(S)-H bond cleavage of the monocyclic beta-lactam ring, or a biosynthetically unprecedented mechanism comprising oxidation of the hydroxyl group of procavaminate to an O-radical, retro-aldol-like decomposition of the O-radical to an aldehyde and a C-centered radical, which is stabilized by the captodative effect, abstraction of a hydrogen atom from the C4'(S) position of the C-centered radical by the Fe(III)-OH species yielding an azomethine ylide, and 1,3-dipolar cycloaddition to the ylide with aldehyde acting as a dipolarophile
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2
this reaction is due to a proclavaminate amidinohydrolase PAH, gene cla
-
-
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2
reaction mechanism
-
-
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O
reaction mechanism
-
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O
reaction mechanism
-
639271, 639272, 639273, 639274, 639275, 639276, 639277, 639278, 639279, 639280, 639283
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O
reaction mechanism
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O
kinetic mechanism
-
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O
substrate-binding mechanism
-
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O
substrate-binding mechanism
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O
third reaction: catalyses three separate oxidative reactions in the pathway for the biosynthesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC 3.5.3.22, proclavaminate amidinohydrolase. The three reactions are all catalysed at the same nonheme iron site
-
-
-
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O
reaction mechanism
-
-
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O
reaction mechanism
-
-
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O
reaction mechanism
-
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O
reaction mechanism
-
639271, 639272, 639273, 639274, 639275, 639276, 639277, 639278, 639279, 639280, 639283
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O
reaction mechanism
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O
kinetic mechanism
-
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O
substrate-binding mechanism
-
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O
substrate-binding mechanism
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O
second reaction: catalyses three separate oxidative reactions in the pathway for the biosynthesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC 3.5.3.22, proclavaminate amidinohydrolase. The three reactions are all catalysed at the same nonheme iron site
-
-
-
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O
reaction mechanism
-
-
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O
reaction mechanism
-
-
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(2S,3R)-proclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
(3S,5S)-dihydroclavaminate + 2-oxoglutarate + O2
(3S,5S)-clavaminate + succinate + CO2 + H2O
Substrates: the enzyme is involved in clavulanic acid biosynthesis
Products: -
?
2-oxoglutarate + O2
? + H2O2
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
E-(2S)-5-amino-2(2'-oxoazetidin-1-yl)-pent-3,4-enoate + succinate + CO2 + H2O + ?
-
Substrates: isozyme CS2
Products: 10% of the product is proclavaminate, 90% of the product is E-(2S)-5-amino-2(2'-oxoazetidin-1-yl)-pent-3,4-enoate
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
N-alpha-acetyl-L-arginine + 2-oxoglutarate + O2
4-hydroxy-N-alpha-acetyl-L-arginine + succinate + CO2 + H2O
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
additional information
?
-
(2S,3R)-proclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
r
(2S,3R)-proclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
r
2-oxoglutarate + O2
? + H2O2
-
Substrates: side reaction in absence of proclavaminate, oxidative decarboxylation of 2-oxoglutarate in presence of Fe2+ and formation of peroxide, which inactivates the enzyme
Products: -
?
2-oxoglutarate + O2
? + H2O2
-
Substrates: -
Products: -
?
2-oxoglutarate + O2
? + H2O2
Substrates: in absence or presence of the substrate proclavaminate, inactivation of the enzyme
Products: -
?
2-oxoglutarate + O2
? + H2O2
Substrates: molecular mechanism
Products: -
?
2-oxoglutarate + O2
? + H2O2
-
Substrates: side reaction in absence of proclavaminate, oxidative decarboxylation of 2-oxoglutarate in presence of Fe2+ and formation of peroxide, which inactivates the enzyme
Products: -
?
2-oxoglutarate + O2
? + H2O2
Substrates: varying amounts of unsaturated six-coordinate ferrous species exist in the substrate complexes which correlate to this uncoupled reaction
Products: -
?
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
Substrates: -
Products: -
?
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: 10% of the product is proclavaminate, 90% of the product is E-(2S)-5-amino-2(2'-oxoazetidin-1-yl)-pent-3,4-enoate
?
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: this reaction is due to a proclavaminate amidinohydrolase, i.e. cla
Products: -
?
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
Substrates: this reaction is due to a proclavaminate amidinohydrolase, i.e. cla
Products: -
?
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: this reaction is due to a proclavaminate amidinohydrolase, i.e. cla
Products: -
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: hydroxylation
Products: -
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: hydroxylation
Products: -
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
Substrates: -
Products: -
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: hydroxylation
Products: -
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
Substrates: hydroxylation
Products: -
?
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
-
Substrates: cyclization
Products: -
?
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
Substrates: -
Products: -
?
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
-
Substrates: stereochemical course of oxygen insertion
Products: -
?
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
-
639036, 639270, 639273, 639274, 639275, 639276, 639277, 639278, 639279, 639280, 639282, 639283 Substrates: cyclization
Products: -
?
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
Substrates: cyclization
Products: -
?
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
-
Substrates: cyclization
Products: 5S) enantiomer
?
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
-
Substrates: syn-elimination of the requisite hydrogens
Products: -
?
N-alpha-acetyl-L-arginine + 2-oxoglutarate + O2
4-hydroxy-N-alpha-acetyl-L-arginine + succinate + CO2 + H2O
-
Substrates: hydroxylation
Products: -
?
N-alpha-acetyl-L-arginine + 2-oxoglutarate + O2
4-hydroxy-N-alpha-acetyl-L-arginine + succinate + CO2 + H2O
Substrates: hydroxylation
Products: -
?
N-alpha-acetyl-L-arginine + 2-oxoglutarate + O2
4-hydroxy-N-alpha-acetyl-L-arginine + succinate + CO2 + H2O
-
Substrates: isozyme CS2
Products: -
?
N-alpha-acetyl-L-arginine + 2-oxoglutarate + O2
4-hydroxy-N-alpha-acetyl-L-arginine + succinate + CO2 + H2O
Substrates: isozyme CAS1
Products: -
?
N-alpha-acetyl-L-arginine + 2-oxoglutarate + O2
4-hydroxy-N-alpha-acetyl-L-arginine + succinate + CO2 + H2O
-
Substrates: isozyme CAS2
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: saturation
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: no activity with the racemic erythro isomers (2S,3S) and (2R,3R)
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: specific for the threo-(2S,3R) enantiomer
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
Substrates: -
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: product is a transient intermediate in the overall reaction process
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: (4'RS)-rac-proclavaminate
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
639036, 639270, 639271, 639272, 639273, 639274, 639275, 639276, 639278, 639279, 639280, 639282, 639283 Substrates: saturation
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
Substrates: saturation
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: saturation
Products: product is a transient intermediate in the overall reaction process
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: no activity with the racemic erythro isomers (2S,3S) and (2R,3R)
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: specific for the threo-(2S,3R) enantiomer
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: stereochemical course of oxygen insertion
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
Substrates: the enzyme is involved in clavulanic acid biosynthesis
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: saturation
Products: -
?
additional information
?
-
-
Substrates: dependent on O2 and 2-oxoglutarate
Products: -
?
additional information
?
-
-
Substrates: enzyme plays a critical role in the biosynthesis of the clavam metabolites
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: dependent on O2 and 2-oxoglutarate
Products: -
?
additional information
?
-
-
Substrates: enzyme plays a critical role in the biosynthesis of the clavam metabolites
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: specific for 2-oxoglutarate
Products: -
?
additional information
?
-
-
Substrates: specific for 2-oxoglutarate
Products: -
?
additional information
?
-
-
Substrates: specific for 2-oxoglutarate
Products: -
?
additional information
?
-
-
Substrates: specific for 2-oxoglutarate
Products: -
?
additional information
?
-
-
Substrates: specific for 2-oxoglutarate
Products: -
?
additional information
?
-
-
Substrates: stereospecificity
Products: -
?
additional information
?
-
-
Substrates: stereospecificity
Products: -
?
additional information
?
-
-
Substrates: stereospecificity
Products: -
?
additional information
?
-
-
Substrates: 1 or more histidine as well as cysteine residue located at or near the active site or in the metal binding site, critical for catalysis
Products: -
?
additional information
?
-
-
Substrates: substrate-binding
Products: -
?
additional information
?
-
Substrates: substrate-binding
Products: -
?
additional information
?
-
-
Substrates: dependent on O2 and 2-oxoglutarate
Products: -
?
additional information
?
-
-
Substrates: dependent on O2 and 2-oxoglutarate
Products: -
?
additional information
?
-
-
Substrates: dependent on O2 and 2-oxoglutarate
Products: -
?
additional information
?
-
-
Substrates: dependent on O2 and 2-oxoglutarate
Products: -
?
additional information
?
-
-
Substrates: dependent on O2 and 2-oxoglutarate
Products: -
?
additional information
?
-
Substrates: dependent on O2 and 2-oxoglutarate
Products: -
?
additional information
?
-
-
Substrates: enzyme has a requirement for the 3-hydroxyl group and is specific for C-5 analogues of proclavaminate
Products: -
?
additional information
?
-
-
Substrates: 4'-vinyl proclavaminate, 4'-ethynyl proclavaminate, and 4-cyclopropyl proclavaminate are no substrates
Products: -
?
additional information
?
-
Substrates: structure-function correlation
Products: -
?
additional information
?
-
-
Substrates: no activity with dehydroproclavaminate and C-5 oxygenated, N-formyl, or N-acetylglycyl proclavaminate derivatives
Products: -
?
additional information
?
-
-
Substrates: enzyme plays a critical role in the biosynthesis of the clavam metabolites
Products: -
?
additional information
?
-
-
Substrates: enzyme plays a critical role in the biosynthesis of the clavam metabolites
Products: -
?
additional information
?
-
-
Substrates: involved in the conversion of monocyclic beta-lactams into bicyclic beta-lactams
Products: -
?
additional information
?
-
-
Substrates: involved in the conversion of monocyclic beta-lactams into bicyclic beta-lactams
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: enzyme plays a critical role in the biosynthesis of the clavam metabolites
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(3S,5S)-dihydroclavaminate + 2-oxoglutarate + O2
(3S,5S)-clavaminate + succinate + CO2 + H2O
Substrates: the enzyme is involved in clavulanic acid biosynthesis
Products: -
?
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
additional information
?
-
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
Substrates: -
Products: -
?
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: this reaction is due to a proclavaminate amidinohydrolase, i.e. cla
Products: -
?
deoxyamidinoproclavaminate + 2-oxoglutarate + O2
amidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: this reaction is due to a proclavaminate amidinohydrolase, i.e. cla
Products: -
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
guanidinoproclavaminate + succinate + CO2 + H2O
Substrates: -
Products: -
?
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
dihydroclavaminate + 2-oxoglutarate + O2
clavaminate + succinate + CO2 + H2O
Substrates: -
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
Substrates: -
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: product is a transient intermediate in the overall reaction process
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
Substrates: the enzyme is involved in clavulanic acid biosynthesis
Products: -
?
proclavaminate + 2-oxoglutarate + O2
dihydroclavaminate + succinate + CO2 + H2O
-
Substrates: -
Products: -
?
additional information
?
-
-
Substrates: enzyme plays a critical role in the biosynthesis of the clavam metabolites
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: enzyme plays a critical role in the biosynthesis of the clavam metabolites
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: enzyme plays a critical role in the biosynthesis of the clavam metabolites
Products: -
?
additional information
?
-
-
Substrates: enzyme plays a critical role in the biosynthesis of the clavam metabolites
Products: -
?
additional information
?
-
-
Substrates: involved in the conversion of monocyclic beta-lactams into bicyclic beta-lactams
Products: -
?
additional information
?
-
-
Substrates: involved in the conversion of monocyclic beta-lactams into bicyclic beta-lactams
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
additional information
?
-
-
Substrates: enzyme plays a critical role in the biosynthesis of the clavam metabolites
Products: -
?
additional information
?
-
-
Substrates: biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor
Products: -
?
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