Disease on EC 1.14.11.27 - [histone H3]-dimethyl-L-lysine36 demethylase

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DISEASE
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Adenocarcinoma
GASC1 expression in lung carcinoma is associated with smoking and prognosis of squamous cell carcinoma.
Influence of the KDM4A rs586339 polymorphism on overall survival in Asian non-small-cell lung cancer patients.
KDM4D Predicts Recurrence in Exocrine Pancreatic Cells of Resection Margins from Patients with Pancreatic Adenocarcinoma.
Lysine demethylase 2 (KDM2B) regulates hippo pathway via MOB1 to promote pancreatic ductal adenocarcinoma (PDAC) progression.
Overexpression of histone demethylase JMJD5 promotes metastasis and indicates a poor prognosis in breast cancer.
Stimulation of ?-catenin and colon cancer cell growth by the KDM4B histone demethylase.
Ataxia Telangiectasia
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Atherosclerosis
Identification of the histone lysine demethylase KDM4A/JMJD2A as a novel epigenetic target in M1 macrophage polarization induced by oxidized LDL.
Bone Diseases, Metabolic
Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.
Brain Diseases
KDM4B histone demethylase and G9a regulate expression of vascular adhesion proteins in cerebral microvessels.
Breast Neoplasms
A three-gene signature and clinical outcome in esophageal squamous cell carcinoma.
Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.
Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function.
Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro.
Erratum to: JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI.
Expression of JMJD2A in infiltrating duct carcinoma was markedly higher than fibroadenoma, and associated with expression of ARHI, p53 and ER in infiltrating duct carcinoma.
Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer.
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer.
Histone demethylase GASC1--a potential prognostic and predictive marker in invasive breast cancer.
Histone demethylase JMJD5 is essential for embryonic development.
Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p15INK4B, p16INK4A, and p57KIP2 transcription.
Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1.
JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI.
JMJD2A-dependent silencing of Sp1 in advanced breast cancer promotes metastasis by downregulation of DIRAS3.
KDM3A is associated with tumor metastasis and modulates colorectal cancer cell migration and invasion.
KDM3A regulates Slug expression to promote the invasion of MCF7 breast cancer cells in hypoxia.
KDM4 inhibition targets breast cancer stem-like cells.
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer.
Kdm4c is Recruited to Mitotic Chromosomes and Is Relevant for Chromosomal Stability, Cell Migration and Invasion of Triple Negative Breast Cancer Cells.
Lysine demethylase 2A expression in cancer-associated fibroblasts promotes breast tumour growth.
Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1.
Lysine demethylase KDM2A inhibits TET2 to promote DNA methylation and silencing of tumor suppressor genes in breast cancer.
Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53.
Lysine demethylase KDM3A regulates nanophotonic hyperthermia resistance generated by 2D silicene in breast cancer.
Oncogenic features of the JMJD2A histone demethylase in breast cancer.
Overexpression of histone demethylase JMJD5 promotes metastasis and indicates a poor prognosis in breast cancer.
Post-Transcriptional Regulation of the GASC1 Oncogene with Active Tumor-Targeted siRNA-Nanoparticles.
Soybean (Glycine max) prevents the progression of breast cancer cells by downregulating the level of histone demethylase JMJD5.
The Histone Demethylase Enzymes KDM3A and KDM4B Co-Operatively Regulate Chromatin Transactions of the Estrogen Receptor in Breast Cancer.
Carcinogenesis
Cooperation between ETS variant 2 and Jumonji domain?containing 2 histone demethylases.
Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function.
ETS transcription factor ERG cooperates with histone demethylase KDM4A.
Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.
Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1.
Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc.
Identification and functional implication of nuclear localization signals in the N-terminal domain of JMJD5.
Influence of the KDM4A rs586339 polymorphism on overall survival in Asian non-small-cell lung cancer patients.
JMJD2A sensitizes gastric cancer to chemotherapy by cooperating with CCDC8.
JMJD5 is a potential oncogene for colon carcinogenesis.
Jumonji domain containing 2A predicts prognosis and regulates cell growth in lung cancer depending on miR-150.
KDM4A promotes the growth of non-small cell lung cancer by mediating the expression of Myc via DLX5 through the Wnt/?-catenin signaling pathway.
KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis.
KDM4B promotes DNA damage response via STAT3 signaling and is a target of CREB in colorectal cancer cells.
KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism.
p300 Acetylates JHDM1A to inhibit osteosarcoma carcinogenesis.
Post-Transcriptional Regulation of the GASC1 Oncogene with Active Tumor-Targeted siRNA-Nanoparticles.
Rare germline alterations in cancer-related genes associated with the risk of multiple primary tumor development.
Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.
The Emerging Role of Lysine Demethylases in DNA Damage Response: Dissecting the recruitment mode of KDM4D/JMJD2D to DNA damage sites.
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b).
The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells.
The oncogenic role of GASC1 in chemically induced mouse skin cancer.
USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-?2 transcription.
Wnt-Induced Stabilization of KDM4C Is Required for Wnt/?-Catenin Target Gene Expression and Glioblastoma Tumorigenesis.
Carcinoma
A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB.
A three-gene signature and clinical outcome in esophageal squamous cell carcinoma.
Down-regulation of JMJD5 suppresses metastasis and induces apoptosis in oral squamous cell carcinoma by regulating p53/NF-?B pathway.
Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model.
Electrophilic Zinc Homoenolates: Synthesis of Cyclopropylamines from Cyclopropanols and Amines.
Expression of JMJD2A in infiltrating duct carcinoma was markedly higher than fibroadenoma, and associated with expression of ARHI, p53 and ER in infiltrating duct carcinoma.
GASC1 expression in lung carcinoma is associated with smoking and prognosis of squamous cell carcinoma.
GASC1 Promotes Stemness of Esophageal Squamous Cell Carcinoma via NOTCH1 Promoter Demethylation.
Histone demethylase GASC1, a potential prognostic and predictive marker in esophageal squamous cell carcinoma.
Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.
Identification and characterization of JMJD2 family genes in silico.
Identification and functional analysis of 9p24 amplified genes in human breast cancer.
JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells.
JMJD2A facilitates growth and inhibits apoptosis of cervical cancer cells by downregulating tumor suppressor miR?491?5p.
KDM3A is not associated with metastasis and prognosis of breast cancer.
KDM4A as a prognostic marker of oral squamous cell carcinoma: Evidence from tissue microarray studies in a multicenter cohort.
KDM4A, KDM4B and KDM4C in non-small cell lung cancer.
Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
Carcinoma in Situ
Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.
Carcinoma, Hepatocellular
Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription ofCDKN1A686.
Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells.
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
Carcinoma, Non-Small-Cell Lung
A Coding Single-Nucleotide Polymorphism in Lysine Demethylase KDM4A Associates with Increased Sensitivity to mTOR Inhibitors.
JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells.
KDM4A promotes the growth of non-small cell lung cancer by mediating the expression of Myc via DLX5 through the Wnt/?-catenin signaling pathway.
KDM4A, KDM4B and KDM4C in non-small cell lung cancer.
SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A.
Carcinoma, Renal Cell
KDM3A is not associated with metastasis and prognosis of breast cancer.
Carcinoma, Squamous Cell
A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB.
GASC1 expression in lung carcinoma is associated with smoking and prognosis of squamous cell carcinoma.
Identification and functional analysis of 9p24 amplified genes in human breast cancer.
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
Cardiomegaly
The Histone Demethylase JMJD2A Modulates the Induction of Hypertrophy Markers in iPSC-Derived Cardiomyocytes.
The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice.
Cardiomyopathy, Hypertrophic
The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice.
Chordoma
365?Epigenetic Profiling Reveals a Unique Histone Code in Chordoma.
Colitis
Inhibition of KDM4A activity as a strategy to suppress interleukin-6 production and attenuate colitis induction.
Colonic Neoplasms
A New Family of Jumonji C Domain-Containing KDM Inhibitors Inspired by Natural Product Purpurogallin.
Histone demethylase KDM4C regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells.
Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors.
Stimulation of ?-catenin and colon cancer cell growth by the KDM4B histone demethylase.
The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells.
Colorectal Neoplasms
Histone demethylase KDM4C regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells.
Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes.
KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation.
KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer.
KDM4B promotes DNA damage response via STAT3 signaling and is a target of CREB in colorectal cancer cells.
Stimulation of ?-catenin and colon cancer cell growth by the KDM4B histone demethylase.
Diabetes Mellitus, Type 1
Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C.
Endometrial Neoplasms
Expression and effects of JMJD2A histone demethylase in endometrial carcinoma.
KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27kip1.
Esophageal Neoplasms
Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.
The oncogenic role of GASC1 in chemically induced mouse skin cancer.
Esophageal Squamous Cell Carcinoma
A three-gene signature and clinical outcome in esophageal squamous cell carcinoma.
GASC1 Promotes Stemness of Esophageal Squamous Cell Carcinoma via NOTCH1 Promoter Demethylation.
Histone demethylase GASC1, a potential prognostic and predictive marker in esophageal squamous cell carcinoma.
Identification and characterization of JMJD2 family genes in silico.
Fibroadenoma
Expression of JMJD2A in infiltrating duct carcinoma was markedly higher than fibroadenoma, and associated with expression of ARHI, p53 and ER in infiltrating duct carcinoma.
Gastrointestinal Stromal Tumors
Correction to: Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1?/VEGFA signalling.
Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1?/VEGFA signalling.
Glioblastoma
Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc.
Wnt-Induced Stabilization of KDM4C Is Required for Wnt/?-Catenin Target Gene Expression and Glioblastoma Tumorigenesis.
Glioma
Downregulation of KDM4A Suppresses the Survival of Glioma Cells by Promoting Autophagy.
The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling.
Hepatitis B
Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx.
Herpes Simplex
Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.
Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency.
Herpesviridae Infections
Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency.
Hodgkin Disease
Strong KDM4B and KDM4D Expression Associates with Radioresistance and Aggressive Phenotype in Classical Hodgkin Lymphoma.
Hypersensitivity
The histone demethylase JMJD2A regulates the expression of BDNF and mediates neuropathic pain in mice.
Infarction, Middle Cerebral Artery
Histone Demethylase KDM4A Inhibition Represses Neuroinflammation and Improves Functional Recovery in Ischemic Stroke.
Infections
JMJD5 is a potential oncogene for colon carcinogenesis.
Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency.
Intellectual Disability
Heterozygous Variants in KDM4B Lead to Global Developmental Delay and Neuroanatomical Defects.
Mechanisms of Origin, Phenotypic Effects and Diagnostic Implications of Complex Chromosome Rearrangements.
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an N{varepsilon}-dimethyl lysine demethylase.
The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction.
Ischemic Stroke
Histone Demethylase KDM4A Inhibition Represses Neuroinflammation and Improves Functional Recovery in Ischemic Stroke.
Latent Autoimmune Diabetes in Adults
Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C.
Leukemia
A three-gene signature and clinical outcome in esophageal squamous cell carcinoma.
Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia.
Histone demethylase JMJD5 is essential for embryonic development.
KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia.
Report of the First Clinical Case of a Moroccan Kabuki Patient with a Novel MLL2 Mutation.
Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.
Unraveling KDM4 histone demethylase expression and its association with adverse cytogenetic findings in chronic lymphocytic leukemia.
Leukemia, Myeloid, Acute
KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia.
Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.
Liver Neoplasms
HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372.
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance.
Lung Neoplasms
A Coding Single-Nucleotide Polymorphism in Lysine Demethylase KDM4A Associates with Increased Sensitivity to mTOR Inhibitors.
Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition.
Differential proteome profiling of pleural effusions from lung cancer and benign inflammatory disease patients.
Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC.
GASC1 expression in lung carcinoma is associated with smoking and prognosis of squamous cell carcinoma.
Influence of the KDM4A rs586339 polymorphism on overall survival in Asian non-small-cell lung cancer patients.
JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5.
JMJD5 interacts with p53 and negatively regulates p53 function in control of cell cycle and proliferation.
KDM4A promotes the growth of non-small cell lung cancer by mediating the expression of Myc via DLX5 through the Wnt/?-catenin signaling pathway.
KDM4A, KDM4B and KDM4C in non-small cell lung cancer.
KLF8 overexpression promotes the growth of human lung cancer cells by promoting the expression of JMJD2A.
SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A.
USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-?2 transcription.
Lymphatic Metastasis
Epigenetic activation of AP1 promotes squamous cell carcinoma metastasis.
Histone demethylase GASC1, a potential prognostic and predictive marker in esophageal squamous cell carcinoma.
KDM4A, KDM4B and KDM4C in non-small cell lung cancer.
Overexpression of histone demethylase JMJD5 promotes metastasis and indicates a poor prognosis in breast cancer.
Lymphoma, B-Cell
Lysine-specific demethylase KDM3A regulates ovarian cancer stemness and chemoresistance.
Macular Degeneration
Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells.
Medulloblastoma
Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.
Memory Disorders
Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice.
Mouth Neoplasms
Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model.
Nasopharyngeal Carcinoma
JMJD2A promotes the Warburg effect and nasopharyngeal carcinoma progression by transactivating LDHA expression.
Neoplasm Metastasis
Down-regulation of JMJD5 suppresses metastasis and induces apoptosis in oral squamous cell carcinoma by regulating p53/NF-?B pathway.
Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model.
Epigenetic activation of AP1 promotes squamous cell carcinoma metastasis.
Expression and effects of JMJD2A histone demethylase in endometrial carcinoma.
Histone demethylase GASC1, a potential prognostic and predictive marker in esophageal squamous cell carcinoma.
JMJD2A facilitates growth and inhibits apoptosis of cervical cancer cells by downregulating tumor suppressor miR?491?5p.
JMJD2A promotes the Warburg effect and nasopharyngeal carcinoma progression by transactivating LDHA expression.
KDM3A is not associated with metastasis and prognosis of breast cancer.
KDM4A as a prognostic marker of oral squamous cell carcinoma: Evidence from tissue microarray studies in a multicenter cohort.
KDM4A promotes the growth of non-small cell lung cancer by mediating the expression of Myc via DLX5 through the Wnt/?-catenin signaling pathway.
KDM4A, KDM4B and KDM4C in non-small cell lung cancer.
KDM4B promotes gastric cancer metastasis by regulating miR-125b-mediated activation of Wnt signaling.
Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial?mesenchymal transition.
Overexpression of histone demethylase JMJD5 promotes metastasis and indicates a poor prognosis in breast cancer.
p300 Acetylates JHDM1A to inhibit osteosarcoma carcinogenesis.
Neoplasms
4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.
A New Family of Jumonji C Domain-Containing KDM Inhibitors Inspired by Natural Product Purpurogallin.
A three-gene signature and clinical outcome in esophageal squamous cell carcinoma.
Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D.
Cooperation between ETS variant 2 and Jumonji domain?containing 2 histone demethylases.
Correction to: Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1?/VEGFA signalling.
CTCF-KDM4A complex correlates with histone modifications that negatively regulate CHD5 gene expression in cancer cell lines.
Depletion of JMJD5 sensitizes tumor cells to microtubule-destabilizing agents by altering microtubule stability.
Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition.
Differential proteome profiling of pleural effusions from lung cancer and benign inflammatory disease patients.
Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.
Down-regulation of JMJD5 suppresses metastasis and induces apoptosis in oral squamous cell carcinoma by regulating p53/NF-?B pathway.
Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model.
Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro.
Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: towards understanding selectivity of inhibitors targeting oncogenic histone demethylases.
Epigenetic activation of AP1 promotes squamous cell carcinoma metastasis.
Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer.
Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription ofCDKN1A686.
Erratum to: JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI.
ETS transcription factor ERG cooperates with histone demethylase KDM4A.
Expression and effects of JMJD2A histone demethylase in endometrial carcinoma.
Expression of JMJD2A in infiltrating duct carcinoma was markedly higher than fibroadenoma, and associated with expression of ARHI, p53 and ER in infiltrating duct carcinoma.
Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
From histones to ribosomes: a chromatin regulator tangoes with translation.
GASC1 expression in lung carcinoma is associated with smoking and prognosis of squamous cell carcinoma.
Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer.
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Genome-wide association study in esophageal cancer using GeneChip mapping 10K array.
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer.
Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency.
Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase.
Histone demethylase GASC1, a potential prognostic and predictive marker in esophageal squamous cell carcinoma.
Histone demethylase GASC1--a potential prognostic and predictive marker in invasive breast cancer.
Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.
Histone Demethylase JMJD2D Interacts With ?-Catenin to Induce Transcription and Activate Colorectal Cancer Cell Proliferation and Tumor Growth in Mice.
Histone demethylase JMJD5 is essential for embryonic development.
Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1.
Histone demethylase KDM4C activates HIF1?/VEGFA signaling through the costimulatory factor STAT3 in NSCLC.
Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc.
Histone Demethylase KDM4C Stimulates the Proliferation of Prostate Cancer Cells via Activation of AKT and c-Myc.
Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1?/VEGFA signalling.
HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372.
Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer.
Identification and functional analysis of 9p24 amplified genes in human breast cancer.
Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.
Identification of Deregulated Signaling Pathways in Jurkat Cells in Response to a Novel Acylspermidine Analogue-N4-Erucoyl Spermidine.
Identification of hub genes and key pathways associated with the progression of gynecological cancer.
IL-6 and IL-8 are involved in JMJD2A-regulated malignancy of ovarian cancer cells.
In vitro evidence of NLRP3 inflammasome regulation by histone demethylase LSD2 in renal cancer: a pilot study.
Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion.
iPSC-Derived Embryoid Bodies as Models of c-Met-Mutated Hereditary Papillary Renal Cell Carcinoma.
JMJD2A attenuation affects cell cycle and tumourigenic inflammatory gene regulation in lipopolysaccharide stimulated neuroectodermal stem cells.
JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI.
JMJD2A facilitates growth and inhibits apoptosis of cervical cancer cells by downregulating tumor suppressor miR?491?5p.
JMJD2A predicts prognosis and regulates cell growth in human gastric cancer.
JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5.
JMJD2A promotes the Warburg effect and nasopharyngeal carcinoma progression by transactivating LDHA expression.
JMJD2A sensitizes gastric cancer to chemotherapy by cooperating with CCDC8.
JMJD5 interacts with p53 and negatively regulates p53 function in control of cell cycle and proliferation.
JMJD5 is a potential oncogene for colon carcinogenesis.
JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1?-mediated glucose metabolism.
Jumonji domain containing 2A predicts prognosis and regulates cell growth in lung cancer depending on miR-150.
KDM3A is associated with tumor metastasis and modulates colorectal cancer cell migration and invasion.
KDM3A is not associated with metastasis and prognosis of breast cancer.
KDM4 inhibition targets breast cancer stem-like cells.
KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis.
KDM4A regulates HIF-1 levels through H3K9me3.
KDM4A, KDM4B and KDM4C in non-small cell lung cancer.
KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer.
KDM4B promotes DNA damage response via STAT3 signaling and is a target of CREB in colorectal cancer cells.
KDM4B promotes epithelial-mesenchymal transition through up-regulation of ZEB1 in pancreatic cancer.
KDM4B promotes gastric cancer metastasis by regulating miR-125b-mediated activation of Wnt signaling.
KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer.
KDM4B: A Nail for Every Hammer?
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer.
KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism.
Kdm4c is Recruited to Mitotic Chromosomes and Is Relevant for Chromosomal Stability, Cell Migration and Invasion of Triple Negative Breast Cancer Cells.
KDM4D Predicts Recurrence in Exocrine Pancreatic Cells of Resection Margins from Patients with Pancreatic Adenocarcinoma.
KDM5C is transcriptionally regulated by BRD4 and promotes castration-resistance prostate cancer cell proliferation by repressing PTEN.
KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation.
LSD1 inhibitors: a patent review (2010-2015).
Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1.
Lysine demethylase KDM2A inhibits TET2 to promote DNA methylation and silencing of tumor suppressor genes in breast cancer.
Lysine Demethylase KDM6A in Differentiation, Development, and Cancer.
Mechanistic insights into KDM4A driven genomic instability.
MiR-10a functions as a tumor suppressor in prostate cancer via targeting KDM4A.
miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells.
Molecular characterization of the porcine JHDM1A gene associated with average daily gain: evaluation its role in skeletal muscle development and growth.
Natural variation in the histone demethylase, KDM4C, influences expression levels of specific genes including those that affect cell growth.
Next-generation sequencing of urine specimens: A novel platform for genomic analysis in patients with non-muscle-invasive urothelial carcinoma treated with bacille Calmette-Guérin.
Novel inhibitors of lysine (K)-specific Demethylase 4A with anticancer activity.
p300 Acetylates JHDM1A to inhibit osteosarcoma carcinogenesis.
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors.
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance.
Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy.
Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells.
SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A.
Soybean (Glycine max) prevents the progression of breast cancer cells by downregulating the level of histone demethylase JMJD5.
Stimulation of ?-catenin and colon cancer cell growth by the KDM4B histone demethylase.
Strong KDM4B and KDM4D Expression Associates with Radioresistance and Aggressive Phenotype in Classical Hodgkin Lymphoma.
SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication.
Targeting the KDM4B-AR-c-Myc axis promotes sensitivity to androgen receptor-targeted therapy in advanced prostate cancer.
Targeting the USP1 dependent KDM4A protein stability as a potential prostate cancer therapy.
TET2 binds the androgen receptor and loss is associated with prostate cancer.
Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
The histone demethylase KDM3A regulates the transcriptional program of the androgen receptor in prostate cancer cells.
The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer.
The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent.
The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells.
The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover.
The oncogenic role of GASC1 in chemically induced mouse skin cancer.
The potential underlying mechanism of the leukemia caused by MLL-fusion and potential treatments.
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
The role of histone demethylase KDM4B in Myc signaling in neuroblastoma.
The role of the histone demethylase KDM4A in cancer.
Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation.
Tudor domain of histone demethylase KDM4B is a reader of H4K20me3.
Upregulation of PSMD10 caused by the JMJD2A histone demethylase.
Neuralgia
The histone demethylase JMJD2A regulates the expression of BDNF and mediates neuropathic pain in mice.
Neuroblastoma
KDM3A is associated with tumor metastasis and modulates colorectal cancer cell migration and invasion.
The role of histone demethylase KDM4B in Myc signaling in neuroblastoma.
Neurodegenerative Diseases
LSD1 inhibitors: a patent review (2010-2015).
Obesity
Correction for Cheng et al., KDM4B protects against obesity and metabolic dysfunction.
JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities.
KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation.
KDM4B protects against obesity and metabolic dysfunction.
Osteoporosis
Histone demethylase KDM4A regulates adipogenic and osteogenic differentiation via epigenetic regulation of C/EBP? and canonical Wnt signaling.
Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.
Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging.
Osteosarcoma
p300 Acetylates JHDM1A to inhibit osteosarcoma carcinogenesis.
Ovarian Neoplasms
Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance.
IL-6 and IL-8 are involved in JMJD2A-regulated malignancy of ovarian cancer cells.
Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial?mesenchymal transition.
Lysine-specific demethylase KDM3A regulates ovarian cancer stemness and chemoresistance.
The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer.
Pancreatic Neoplasms
KDM4B promotes epithelial-mesenchymal transition through up-regulation of ZEB1 in pancreatic cancer.
Pituitary Neoplasms
Synovial Mesenchymal Stem Cell-Derived EV-Packaged miR-31 Downregulates Histone Demethylase KDM2A to Prevent Knee Osteoarthritis.
Prostatic Intraepithelial Neoplasia
Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.
Prostatic Neoplasms
A three-gene signature and clinical outcome in esophageal squamous cell carcinoma.
Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D.
Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens.
Cooperation between ETS variant 2 and Jumonji domain?containing 2 histone demethylases.
ETS transcription factor ERG cooperates with histone demethylase KDM4A.
Genetic alterations and changes in expression of histone demethylases in prostate cancer.
Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.
Histone Demethylase KDM4C Stimulates the Proliferation of Prostate Cancer Cells via Activation of AKT and c-Myc.
KDM3A is not associated with metastasis and prognosis of breast cancer.
KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis.
KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.
LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models.
MiR-10a functions as a tumor suppressor in prostate cancer via targeting KDM4A.
Targeting the KDM4B-AR-c-Myc axis promotes sensitivity to androgen receptor-targeted therapy in advanced prostate cancer.
Targeting the USP1 dependent KDM4A protein stability as a potential prostate cancer therapy.
The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer.
Upregulated KDM4B promotes prostate cancer cell proliferation by activating autophagy.
Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer.
Retinoblastoma
miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells.
Sarcoma, Ewing
KDM3A is associated with tumor metastasis and modulates colorectal cancer cell migration and invasion.
KDM3A is not associated with metastasis and prognosis of breast cancer.
Skin Neoplasms
The oncogenic role of GASC1 in chemically induced mouse skin cancer.
Small Cell Lung Carcinoma
Electrophilic Zinc Homoenolates: Synthesis of Cyclopropylamines from Cyclopropanols and Amines.
Squamous Cell Carcinoma of Head and Neck
Down-regulation of JMJD5 suppresses metastasis and induces apoptosis in oral squamous cell carcinoma by regulating p53/NF-?B pathway.
Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model.
KDM4A as a prognostic marker of oral squamous cell carcinoma: Evidence from tissue microarray studies in a multicenter cohort.
Stomach Neoplasms
JMJD2A predicts prognosis and regulates cell growth in human gastric cancer.
JMJD2A sensitizes gastric cancer to chemotherapy by cooperating with CCDC8.
KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis.
KDM4B promotes epithelial-mesenchymal transition through up-regulation of ZEB1 in pancreatic cancer.
KDM4B promotes gastric cancer metastasis by regulating miR-125b-mediated activation of Wnt signaling.
Systemic Vasculitis
Correction: Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Teratocarcinoma
LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase-dependent proteolysis of the stem-cell protein SOX2.
Tongue Neoplasms
Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model.
Triple Negative Breast Neoplasms
Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p15INK4B, p16INK4A, and p57KIP2 transcription.
KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer.
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer.
Kdm4c is Recruited to Mitotic Chromosomes and Is Relevant for Chromosomal Stability, Cell Migration and Invasion of Triple Negative Breast Cancer Cells.
Overexpression of histone demethylase JMJD5 promotes metastasis and indicates a poor prognosis in breast cancer.
Urinary Bladder Neoplasms
Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition.
Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.
Tumor?infiltrating M2 macrophages driven by specific genomic alterations are associated with prognosis in bladder cancer.
Upregulation of JMJD2A promotes migration and invasion in bladder cancer through regulation of SLUG.
Uterine Cervical Neoplasms
JMJD2A facilitates growth and inhibits apoptosis of cervical cancer cells by downregulating tumor suppressor miR?491?5p.
KDM3A is associated with tumor metastasis and modulates colorectal cancer cell migration and invasion.
Virus Diseases
Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.
LSD1 inhibitors: a patent review (2010-2015).