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IUBMB Comments Requires Fe2+ Aspergillus fumigatus . Both atoms of a dioxygen molecule are incorporated into verruculogen [1,2]. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgin A.
Synonyms fmtF , FmtOx1, FtmF,
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fumitremorgin B + 2-oxoglutarate + 2 O2 + reduced acceptor = verruculogen + succinate + CO2 + H2O + acceptor
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MetaCyc
fumitremorgin A biosynthesis
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fumitremorgin B,2-oxoglutarate:oxygen oxidoreductase (verruculogen-forming)
Requires Fe2+ and ascorbate. Found in the fungus Aspergillus fumigatus. Both atoms of a dioxygen molecule are incorporated into verruculogen [1,2]. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgin A.
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fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2
verruculogen + succinate + CO2 + H2O + A
fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2
verruculogen + succinate + CO2 + H2O + A
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Substrates: -
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fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2
verruculogen + succinate + CO2 + H2O + A
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Substrates: the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgin A
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fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2
verruculogen + succinate + CO2 + H2O + A
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Substrates: fumitremorgin B i.e. (5aR,6S,12S,14aS)-5a,6-dihydroxy-9-methoxy-11-(3-methylbut-2-en-1-yl)-12-(2-methylprop-1-en-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione. Both atoms of a dioxygen molecule are incorporated into verruculogen
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fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2
verruculogen + succinate + CO2 + H2O + A
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Substrates: the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgin A
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ascorbate
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required
ascorbate
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not essential but involved in the FtmF reaction
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0.003
2-oxoglutarate
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pH 6.0, 30°C
0.021
fumitremorgin B
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pH 6.0, 30°C
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0.19
fumitremorgin B
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pH 6.0, 30°C
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brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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FTMF_ASPFM
291
0
32695
Swiss-Prot
other Location (Reliability: 2 )
FTMF_ASPFU
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
291
0
32667
Swiss-Prot
other Location (Reliability: 2 )
FTMF_NEOFI
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
291
0
32740
Swiss-Prot
other Location (Reliability: 2 )
A0A173KZE2_9SPHN
297
0
32767
TrEMBL
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A0A8J8W2H2_9EURO
301
0
33565
TrEMBL
other Location (Reliability: 3 )
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35100
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2 * 35100, calculated from sequence
38000
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2 * 38000, SDS-PAGE
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homodimer
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2 * 38000, SDS-PAGE
homodimer
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2 * 35100, calculated from sequence
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37
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10 min, 10% loss of activity
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expressed in Escherichia coli as a His6-tagged fusion protein
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Kato, N.; Suzuki, H.; Takagi, H.; Uramoto, M.; Takahashi, S.; Osada, H.
Gene disruption and biochemical characterization of verruculogen synthase of Aspergillus fumigatus
ChemBioChem
12
711-714
2011
Aspergillus fumigatus
brenda
Steffan, N.; Grundmann, A.; Afiyatullov, S.; Ruan, H.; Li, S.M.
FtmOx1, a non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus
Org. Biomol. Chem.
7
4082-4087
2009
Aspergillus fumigatus
brenda
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