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EC Tree
The enzyme appears in viruses and cellular organisms
Reaction Schemes
a [histone H3]-N6,N6,N6-trimethyl-L-lysine56
+
3
+
3
=
a [histone H3]-L-lysine56
+
3
+
3
+
3
Synonyms
kdm4dl,
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lysine-specific demethylase 4E
-
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a [histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
(1a)
-
-
a [histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 3 2-oxoglutarate + 3 O2 = a [histone H3]-L-lysine56 + 3 succinate + 3 formaldehyde + 3 CO2
overall reaction
-
-
a [histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
(1b)
-
-
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[histone H3]-N6,N6,N6-trimethyl-L-lysine56,2-oxoglutarate:oxygen oxidoreductase
-
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[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
additional information
?
-
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
-
-
?
additional information
?
-
trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65
-
?
additional information
?
-
trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65
-
?
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[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
additional information
?
-
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
-
-
-
?
additional information
?
-
trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65
-
-
?
additional information
?
-
trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65
-
-
?
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-
UniProt
brenda
cf. EC 1.14.11.65
UniProt
brenda
isoform JMJD2d
UniProt
brenda
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low expression level
brenda
-
brenda
embryonic fibroblast cell
brenda
low expression level
brenda
predominant expression
brenda
low expression level
brenda
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KDM4A predominantly localizes to heterochromatin and regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair
brenda
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physiological function
KDM4A regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair. KDM4A demethylase activity is dispensable for position-effect variegation. KDM4A enzymatic activity is required to relocate heterochromatic double-strand breaks outside the domain, and for organismal survival when DNA repair is compromised. DNA damage triggers KDM4A-dependent changes in the levels of H3K56me3. In heterochromatin, KDM4A loss alters H3K9me3 but not H3K36me3 levels and KDM4A is required for demethylation of H3K56me3 during DNA damage
physiological function
overexpression of human KDM4E strongly diminishes [histone H3]-N6,N6,N6-trimethyl-L-lysine9, as well as [histone H3]-N6,N6,N6-trimethyl-L-lysine56 signals, in HeLa Kyoto cells. The loss of the respective trimethyl signal is accompanied with an increase in the monomethyl, but not dimethyl state. the activity is dependent on the enzymatic active jmjC domain
physiological function
overexpression of mouse Jmjd2D strongly diminishes [histone H3]-N6,N6,N6-trimethyl-L-lysine9, as well as [histone H3]-N6,N6,N6-trimethyl-L-lysine56 signals, in HeLa Kyoto cells. The loss of the respective trimethyl signal is accompanied with an increase in the monomethyl, but not dimethyl state. the activity is dependent on the enzymatic active jmjC domain
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KDM4E_HUMAN
506
0
56804
Swiss-Prot
other Location (Reliability: 3 )
KDM4D_MOUSE
510
0
57212
Swiss-Prot
other Location (Reliability: 3 )
KDM4A_DROME
495
0
56990
Swiss-Prot
other Location (Reliability: 2 )
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Colmenares, S.U.; Swenson, J.M.; Langley, S.3.; Kennedy, C.; Costes, S.V.; Karpen, G.H.
Drosophila histone demethylase KDM4A has enzymatic and non-enzymatic roles in controlling heterochromatin integrity
Dev. Cell
42
156-169
2017
Drosophila melanogaster (Q9V333)
brenda
Jack, A.P.M.; Bussemer, S.; Hahn, M.; Pünzeler, S.; Snyder, M.; Wells, M.; Csankovszki, G.; Solovei, I.; Schotta, G.; Hake, S.B.
H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization
PLoS ONE
8
e51765
2013
Homo sapiens (B2RXH2), Mus musculus (Q3U2K5)
brenda
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1.14.11.B19 [histone H3]-trimethyl-L-lysine56 demethylase
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