Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 1.14.12.17 - nitric oxide dioxygenase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Vitreoscilla hemoglobin aids respiration under hypoxic conditions in its native host.
Adenocarcinoma
Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence.
Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate.
Adenomatous Polyposis Coli
Prolonged sampling of spontaneous sputum improves sensitivity of hypermethylation analysis for lung cancer.
Atherosclerosis
Recombinant Human Cytoglobin Prevents Atherosclerosis by Regulating Lipid Metabolism and Oxidative Stress.
Brain Injuries
Cerebral expression of neuroglobin and cytoglobin after deep hypothermic circulatory arrest in neonatal piglets.
Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model.
Breast Neoplasms
Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells.
Old proteins - new locations: myoglobin, haemoglobin, neuroglobin and cytoglobin in solid tumours and cancer cells.
Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death.
Carcinogenesis
Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice.
Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts.
Dynamic features of carboxy cytoglobin distal mutants investigated by molecular dynamics simulations.
Carcinoma
Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer.
Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin.
Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate.
Molecular Staging of Surgical Margins in Oral Squamous Cell Carcinoma Using Promoter Methylation of p16(INK4A), Cytoglobin, E-cadherin, and TMEFF2.
Carcinoma, Hepatocellular
Cytoglobin ameliorates the stemness of hepatocellular carcinoma via coupling oxidative-nitrosative stress signals.
Carcinoma, Non-Small-Cell Lung
Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer.
Carcinoma, Squamous Cell
Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer.
Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin.
Cardiotoxicity
Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats.
Colitis
Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice.
Colitis, Ulcerative
Cytoglobin expression of rectal subepithelial myofibroblasts: Significant alterations of cytoglobin+ stromal cells in long-standing ulcerative colitis.
Colonic Neoplasms
Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells.
Communicable Diseases
Flavohemoglobin and nitric oxide detoxification in the human protozoan parasite Giardia intestinalis.
Cystitis
Edaravone mitigates hemorrhagic cystitis by modulating Nrf2, TLR-4/NF-?B, and JAK1/STAT3 signaling in cyclophosphamide-intoxicated rats.
Dehydration
Optimization of immunogold labeling TEM. An ELISA-based method for rapid and convenient simulation of processing conditions for quantitative detection of antigen.
Diabetic Nephropathies
Liuwei Dihuang pill treats diabetic nephropathy in rats by inhibiting of TGF-?/SMADS, MAPK, and NF-kB and upregulating expression of cytoglobin in renal tissues.
Down Syndrome
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Fatty Liver
TGF-?1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis.
Fatty Liver, Alcoholic
Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin.
Glioblastoma
Hypoxia differentially upregulates the expression of embryonic, fetal and adult hemoglobin in human glioblastoma cells.
Glioma
Knockdown of cytoglobin expression sensitizes human glioma cells to radiation and oxidative stress.
The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients.
Head and Neck Neoplasms
Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer.
Hereditary Complement Deficiency Diseases
Genetic engineering of Enterobacter aerogenes with the Vitreoscilla hemoglobin gene: cell growth, survival, and antioxidant enzyme status under oxidative stress.
Infarction, Middle Cerebral Artery
Effect of permanent middle cerebral artery occlusion on Cytoglobin expression in the mouse brain.
Infections
A Nitric Oxide-Responsive Transcriptional Regulator NsrR Cooperates With Lrp and CRP to Tightly Control the hmpA Gene in Vibrio vulnificus.
Hemoglobin and its derived peptides may play a role in the antibacterial mechanism of the vagina.
Hemoglobin LjGlb1-1 is involved in nodulation and regulates the level of nitric oxide in the Lotus japonicus-Mesorhizobium loti symbiosis.
Proteomic analysis of fungal host factors differentially expressed by Fusarium graminearum infected with Fusarium graminearum virus-DK21.
Role of flavohemoglobin in combating nitrosative stress in uropathogenic Escherichia coli - Implications for urinary tract infection.
{alpha}1-Acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium.
Keloid
Role of Hypoxia Inducible Factor-1 Alpha (HIF-1?) in Cytoglobin Expression and Fibroblast Proliferation of Keloids.
Keratoderma, Palmoplantar, Diffuse
Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression.
Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer.
Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells.
Liver Cirrhosis
Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.
Cytoglobin Exhibits Anti-Fibrosis Activity on Liver In Vivo and In Vitro.
Cytoglobin expression in the hepatic stellate cell line HSC-T6 is regulated by extracellular matrix proteins dependent on FAK-signalling.
Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
Localization and expression pattern of cytoglobin in carbon tetrachloride-induced liver fibrosis.
Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.
Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis.
Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice.
Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis.
Liver Diseases
Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin.
Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.
Protective effects of recombinant human cytoglobin against chronic alcohol-induced liver disease in vivo and in vitro.
Liver Neoplasms
Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.
Lung Neoplasms
?Np63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer.
Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines.
DNA hypermethylation analysis in sputum for the diagnosis of lung cancer: training validation set approach.
DNA hypermethylation analysis in sputum of asymptomatic subjects at risk for lung cancer participating in the NELSON trial: argument for maximum screening interval of 2?years.
Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer.
[Hypoxia upregulates the expression of cytoglobin in lung cancer cells]
Melanoma
A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma.
Melanoma transition is frequently accompanied by a loss of cytoglobin expression in melanocytes: a novel expression site of cytoglobin.
Mouth Neoplasms
Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing.
Neoplasms
A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma.
Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells.
COL1A1, PRPF40A, and UCP2 correlate with hypoxia markers in non-small cell lung cancer.
Cytoglobin ameliorates the stemness of hepatocellular carcinoma via coupling oxidative-nitrosative stress signals.
Cytoglobin as a Biomarker in Cancer: Potential Perspective for Diagnosis and Management.
Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-?B Pathway Inhibition.
Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.
Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines.
Cytoglobin in tumor hypoxia: novel insights into cancer suppression.
Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer.
Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells.
Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin.
Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.
Cytoglobin: a novel potential gene medicine for fibrosis and cancer therapy.
DNA damage induced activation of Cygb stabilizes p53 and mediates G1 arrest.
Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression.
Emerging perspectives on cytoglobin, beyond NO dioxygenase and peroxidase.
Expression and biological role of cytoglobin in human ovarian cancer.
Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer.
Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate.
Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues.
Knockdown of cytoglobin expression sensitizes human glioma cells to radiation and oxidative stress.
Myofibroblasts in pulmonary and brain metastases of alveolar soft-part sarcoma: a novel target for treatment?
Old proteins - new locations: myoglobin, haemoglobin, neuroglobin and cytoglobin in solid tumours and cancer cells.
Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.
Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing.
Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells.
Protection from nitrosative stress: A central role for microbial flavohemoglobin.
Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death.
Redox and peroxidase activities of the hemoglobin superfamily - relevancy to health and disease.
Synergistic effects between catalase inhibitors and modulators of nitric oxide metabolism on tumor cell apoptosis.
The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor.
The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism.
The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients.
The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.
[Current situation and future prospect of cytoglobin research].
[Hypoxia upregulates the expression of cytoglobin in lung cancer cells]
Nervous System Diseases
Brain globins in physiology and pathology.
Neuroblastoma
Anoxia or oxygen and glucose deprivation in SH-SY5Y cells: a step closer to the unraveling of neuroglobin and cytoglobin functions.
Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death.
Overexpression of cytoglobin gene inhibits hypoxic injury to SH-SY5Y neuroblastoma cells.
Neurodegenerative Diseases
Neuroglobin and Cytoglobin expression in the human brain.
Redox and peroxidase activities of the hemoglobin superfamily - relevancy to health and disease.
Neuroinflammatory Diseases
Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-?B Pathway Inhibition.
nitric oxide dioxygenase deficiency
Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice.
Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.
Non-alcoholic Fatty Liver Disease
Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.
Ovarian Neoplasms
Expression and biological role of cytoglobin in human ovarian cancer.
Pheochromocytoma
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Pre-Eclampsia
Maternal cytoglobin (CYGB) serum levels in normal and preeclamptic pregnancies.
Prostatic Neoplasms
Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect.
Renal Insufficiency, Chronic
The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease.
Reperfusion Injury
Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro.
Retinal Degeneration
Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice.
Squamous Cell Carcinoma of Head and Neck
Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer.
Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin.
Molecular Staging of Surgical Margins in Oral Squamous Cell Carcinoma Using Promoter Methylation of p16(INK4A), Cytoglobin, E-cadherin, and TMEFF2.
Stroke
Effect of permanent middle cerebral artery occlusion on Cytoglobin expression in the mouse brain.
Triple Negative Breast Neoplasms
Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death.
Tuberculosis
An unconventional hexacoordinated flavohemoglobin from Mycobacterium tuberculosis.
Comparative Analysis of Mycobacterial Truncated Hemoglobin Promoters and the groEL2 Promoter in Free-Living and Intracellular Mycobacteria.
Direct Monitoring of the Reaction between Photochemically Generated Nitric Oxide and Mycobacterium tuberculosis Truncated Hemoglobin N Wild Type and Variant Forms: An Assessment of Computational Mechanistic Predictions.
Hydroxylamine-induced oxidation of ferrous carbonylated truncated hemoglobins from Mycobacterium tuberculosis and Campylobacter jejuni is limited by carbon monoxide dissociation.
Isoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin N.
Ligand binding to truncated hemoglobin N from Mycobacterium tuberculosis is strongly modulated by the interplay between the distal heme pocket residues and internal water.
Ligand interactions in the distal heme pocket of Mycobacterium tuberculosis truncated hemoglobin N: roles of TyrB10 and GlnE11 residues.
Mechanism of product release in NO detoxification from Mycobacterium tuberculosis truncated hemoglobin N.
Mechanism of the Nitric Oxide Dioxygenase Reaction of Mycobacterium tuberculosis Hemoglobin N.
Mechanistic insight into the enzymatic reduction of truncated hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A motif in electron cycling.
Migration of small ligands in globins: Xe diffusion in truncated hemoglobin N.
Molecular Model of Hemoglobin N from Mycobacterium tuberculosis Bound to Lipid Bilayers: A Combined Spectroscopic and Computational Study.
Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme.
Nitric oxide reactivity with globins as investigated through computer simulation.
Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis haemoglobin, HbN in Escherichia coli.
Oxygen migration pathways in NO-bound truncated hemoglobin.
Regulation of hmp gene transcription in Mycobacterium tuberculosis: effects of oxygen limitation and nitrosative and oxidative stress.
Role of PheE15 gate in ligand entry and nitric oxide detoxification function of mycobacterium tuberculosis truncated hemoglobin N.
Role of Pre-A motif in nitric oxide scavenging by truncated hemoglobin, HbN, of mycobacterium tuberculosis.
Structural characterization of the tunnels of Mycobacterium tuberculosis truncated hemoglobin N from molecular dynamics simulations.
Structure and dynamics of Mycobacterium tuberculosis truncated hemoglobin N: insights from NMR spectroscopy and molecular dynamics simulations.
Theoretical investigations of nitric oxide channeling in Mycobacterium tuberculosis truncated hemoglobin N.
Type I flavohemoglobin of mycobacterium smegmatis is a functional nitric oxide dioxygenase.
Urinary Tract Infections
Role of flavohemoglobin in combating nitrosative stress in uropathogenic Escherichia coli - Implications for urinary tract infection.
Vascular System Injuries
The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling.
Wilms Tumor
Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect.