Disease on EC 1.14.12.17 - nitric oxide dioxygenase
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Acquired Immunodeficiency Syndrome
Vitreoscilla hemoglobin aids respiration under hypoxic conditions in its native host.
Adenocarcinoma
Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence.
Adenocarcinoma
Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate.
Adenomatous Polyposis Coli
Prolonged sampling of spontaneous sputum improves sensitivity of hypermethylation analysis for lung cancer.
Atherosclerosis
Recombinant Human Cytoglobin Prevents Atherosclerosis by Regulating Lipid Metabolism and Oxidative Stress.
Brain Injuries
Cerebral expression of neuroglobin and cytoglobin after deep hypothermic circulatory arrest in neonatal piglets.
Brain Injuries
Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model.
Breast Neoplasms
Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells.
Breast Neoplasms
Old proteins - new locations: myoglobin, haemoglobin, neuroglobin and cytoglobin in solid tumours and cancer cells.
Breast Neoplasms
Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death.
Carcinogenesis
Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice.
Carcinogenesis
Dynamic features of carboxy cytoglobin distal mutants investigated by molecular dynamics simulations.
Carcinoma
Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer.
Carcinoma
Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin.
Carcinoma
Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate.
Carcinoma
Molecular Staging of Surgical Margins in Oral Squamous Cell Carcinoma Using Promoter Methylation of p16(INK4A), Cytoglobin, E-cadherin, and TMEFF2.
Carcinoma, Hepatocellular
Cytoglobin ameliorates the stemness of hepatocellular carcinoma via coupling oxidative-nitrosative stress signals.
Carcinoma, Non-Small-Cell Lung
Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer.
Carcinoma, Squamous Cell
Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer.
Carcinoma, Squamous Cell
Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin.
Cardiotoxicity
Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats.
Colitis
Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice.
Colitis, Ulcerative
Cytoglobin expression of rectal subepithelial myofibroblasts: Significant alterations of cytoglobin+ stromal cells in long-standing ulcerative colitis.
Colonic Neoplasms
Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells.
Communicable Diseases
Flavohemoglobin and nitric oxide detoxification in the human protozoan parasite Giardia intestinalis.
Cystitis
Edaravone mitigates hemorrhagic cystitis by modulating Nrf2, TLR-4/NF-?B, and JAK1/STAT3 signaling in cyclophosphamide-intoxicated rats.
Dehydration
Optimization of immunogold labeling TEM. An ELISA-based method for rapid and convenient simulation of processing conditions for quantitative detection of antigen.
Diabetic Nephropathies
Liuwei Dihuang pill treats diabetic nephropathy in rats by inhibiting of TGF-?/SMADS, MAPK, and NF-kB and upregulating expression of cytoglobin in renal tissues.
Down Syndrome
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Fatty Liver
TGF-?1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis.
Fatty Liver, Alcoholic
Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin.
Glioblastoma
Hypoxia differentially upregulates the expression of embryonic, fetal and adult hemoglobin in human glioblastoma cells.
Glioma
Knockdown of cytoglobin expression sensitizes human glioma cells to radiation and oxidative stress.
Glioma
The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients.
Head and Neck Neoplasms
Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer.
Hereditary Complement Deficiency Diseases
Genetic engineering of Enterobacter aerogenes with the Vitreoscilla hemoglobin gene: cell growth, survival, and antioxidant enzyme status under oxidative stress.
Infarction, Middle Cerebral Artery
Effect of permanent middle cerebral artery occlusion on Cytoglobin expression in the mouse brain.
Infections
A Nitric Oxide-Responsive Transcriptional Regulator NsrR Cooperates With Lrp and CRP to Tightly Control the hmpA Gene in Vibrio vulnificus.
Infections
Hemoglobin and its derived peptides may play a role in the antibacterial mechanism of the vagina.
Infections
Hemoglobin LjGlb1-1 is involved in nodulation and regulates the level of nitric oxide in the Lotus japonicus-Mesorhizobium loti symbiosis.
Infections
Proteomic analysis of fungal host factors differentially expressed by Fusarium graminearum infected with Fusarium graminearum virus-DK21.
Infections
Role of flavohemoglobin in combating nitrosative stress in uropathogenic Escherichia coli - Implications for urinary tract infection.
Infections
{alpha}1-Acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium.
Keloid
Role of Hypoxia Inducible Factor-1 Alpha (HIF-1?) in Cytoglobin Expression and Fibroblast Proliferation of Keloids.
Keratoderma, Palmoplantar, Diffuse
Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression.
Keratoderma, Palmoplantar, Diffuse
Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer.
Keratoderma, Palmoplantar, Diffuse
Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells.
Liver Cirrhosis
Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.
Liver Cirrhosis
Cytoglobin expression in the hepatic stellate cell line HSC-T6 is regulated by extracellular matrix proteins dependent on FAK-signalling.
Liver Cirrhosis
Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
Liver Cirrhosis
Localization and expression pattern of cytoglobin in carbon tetrachloride-induced liver fibrosis.
Liver Cirrhosis
Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.
Liver Cirrhosis
Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis.
Liver Cirrhosis
Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice.
Liver Cirrhosis
Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis.
Liver Diseases
Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin.
Liver Diseases
Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.
Liver Diseases
Protective effects of recombinant human cytoglobin against chronic alcohol-induced liver disease in vivo and in vitro.
Liver Neoplasms
Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.
Lung Neoplasms
?Np63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer.
Lung Neoplasms
Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines.
Lung Neoplasms
DNA hypermethylation analysis in sputum for the diagnosis of lung cancer: training validation set approach.
Lung Neoplasms
DNA hypermethylation analysis in sputum of asymptomatic subjects at risk for lung cancer participating in the NELSON trial: argument for maximum screening interval of 2?years.
Lung Neoplasms
Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer.
Melanoma
A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma.
Melanoma
Melanoma transition is frequently accompanied by a loss of cytoglobin expression in melanocytes: a novel expression site of cytoglobin.
Mouth Neoplasms
Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing.
Neoplasms
A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma.
Neoplasms
Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells.
Neoplasms
COL1A1, PRPF40A, and UCP2 correlate with hypoxia markers in non-small cell lung cancer.
Neoplasms
Cytoglobin ameliorates the stemness of hepatocellular carcinoma via coupling oxidative-nitrosative stress signals.
Neoplasms
Cytoglobin as a Biomarker in Cancer: Potential Perspective for Diagnosis and Management.
Neoplasms
Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-?B Pathway Inhibition.
Neoplasms
Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.
Neoplasms
Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines.
Neoplasms
Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer.
Neoplasms
Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells.
Neoplasms
Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin.
Neoplasms
Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.
Neoplasms
Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression.
Neoplasms
Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer.
Neoplasms
Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate.
Neoplasms
Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues.
Neoplasms
Knockdown of cytoglobin expression sensitizes human glioma cells to radiation and oxidative stress.
Neoplasms
Myofibroblasts in pulmonary and brain metastases of alveolar soft-part sarcoma: a novel target for treatment?
Neoplasms
Old proteins - new locations: myoglobin, haemoglobin, neuroglobin and cytoglobin in solid tumours and cancer cells.
Neoplasms
Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.
Neoplasms
Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing.
Neoplasms
Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells.
Neoplasms
Protection from nitrosative stress: A central role for microbial flavohemoglobin.
Neoplasms
Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death.
Neoplasms
Redox and peroxidase activities of the hemoglobin superfamily - relevancy to health and disease.
Neoplasms
Synergistic effects between catalase inhibitors and modulators of nitric oxide metabolism on tumor cell apoptosis.
Neoplasms
The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor.
Neoplasms
The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism.
Neoplasms
The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients.
Neoplasms
The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.
Neuroblastoma
Anoxia or oxygen and glucose deprivation in SH-SY5Y cells: a step closer to the unraveling of neuroglobin and cytoglobin functions.
Neuroblastoma
Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death.
Neuroblastoma
Overexpression of cytoglobin gene inhibits hypoxic injury to SH-SY5Y neuroblastoma cells.
Neurodegenerative Diseases
Redox and peroxidase activities of the hemoglobin superfamily - relevancy to health and disease.
Neuroinflammatory Diseases
Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-?B Pathway Inhibition.
nitric oxide dioxygenase deficiency
Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice.
nitric oxide dioxygenase deficiency
Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.
Non-alcoholic Fatty Liver Disease
Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.
Pheochromocytoma
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Pre-Eclampsia
Maternal cytoglobin (CYGB) serum levels in normal and preeclamptic pregnancies.
Prostatic Neoplasms
Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect.
Renal Insufficiency, Chronic
The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease.
Reperfusion Injury
Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro.
Retinal Degeneration
Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice.
Squamous Cell Carcinoma of Head and Neck
Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin.
Squamous Cell Carcinoma of Head and Neck
Molecular Staging of Surgical Margins in Oral Squamous Cell Carcinoma Using Promoter Methylation of p16(INK4A), Cytoglobin, E-cadherin, and TMEFF2.
Stroke
Effect of permanent middle cerebral artery occlusion on Cytoglobin expression in the mouse brain.
Triple Negative Breast Neoplasms
Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death.
Tuberculosis
An unconventional hexacoordinated flavohemoglobin from Mycobacterium tuberculosis.
Tuberculosis
Comparative Analysis of Mycobacterial Truncated Hemoglobin Promoters and the groEL2 Promoter in Free-Living and Intracellular Mycobacteria.
Tuberculosis
Direct Monitoring of the Reaction between Photochemically Generated Nitric Oxide and Mycobacterium tuberculosis Truncated Hemoglobin N Wild Type and Variant Forms: An Assessment of Computational Mechanistic Predictions.
Tuberculosis
Hydroxylamine-induced oxidation of ferrous carbonylated truncated hemoglobins from Mycobacterium tuberculosis and Campylobacter jejuni is limited by carbon monoxide dissociation.
Tuberculosis
Isoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin N.
Tuberculosis
Ligand binding to truncated hemoglobin N from Mycobacterium tuberculosis is strongly modulated by the interplay between the distal heme pocket residues and internal water.
Tuberculosis
Ligand interactions in the distal heme pocket of Mycobacterium tuberculosis truncated hemoglobin N: roles of TyrB10 and GlnE11 residues.
Tuberculosis
Mechanism of product release in NO detoxification from Mycobacterium tuberculosis truncated hemoglobin N.
Tuberculosis
Mechanism of the Nitric Oxide Dioxygenase Reaction of Mycobacterium tuberculosis Hemoglobin N.
Tuberculosis
Mechanistic insight into the enzymatic reduction of truncated hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A motif in electron cycling.
Tuberculosis
Migration of small ligands in globins: Xe diffusion in truncated hemoglobin N.
Tuberculosis
Molecular Model of Hemoglobin N from Mycobacterium tuberculosis Bound to Lipid Bilayers: A Combined Spectroscopic and Computational Study.
Tuberculosis
Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme.
Tuberculosis
Nitric oxide reactivity with globins as investigated through computer simulation.
Tuberculosis
Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis haemoglobin, HbN in Escherichia coli.
Tuberculosis
Regulation of hmp gene transcription in Mycobacterium tuberculosis: effects of oxygen limitation and nitrosative and oxidative stress.
Tuberculosis
Role of PheE15 gate in ligand entry and nitric oxide detoxification function of mycobacterium tuberculosis truncated hemoglobin N.
Tuberculosis
Role of Pre-A motif in nitric oxide scavenging by truncated hemoglobin, HbN, of mycobacterium tuberculosis.
Tuberculosis
Structural characterization of the tunnels of Mycobacterium tuberculosis truncated hemoglobin N from molecular dynamics simulations.
Tuberculosis
Structure and dynamics of Mycobacterium tuberculosis truncated hemoglobin N: insights from NMR spectroscopy and molecular dynamics simulations.
Tuberculosis
Theoretical investigations of nitric oxide channeling in Mycobacterium tuberculosis truncated hemoglobin N.
Tuberculosis
Type I flavohemoglobin of mycobacterium smegmatis is a functional nitric oxide dioxygenase.
Urinary Tract Infections
Role of flavohemoglobin in combating nitrosative stress in uropathogenic Escherichia coli - Implications for urinary tract infection.
Vascular System Injuries
The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling.
Wilms Tumor
Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect.
html completed