Reference on EC 1.14.13.8 - flavin-containing monooxygenase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ziegler, D.M.; Pettit, F.H.
Microsomal oxidases. I. The isolation and dialkylarylamine oxygenase activity of pork liver microsomes
Biochemistry
5
2932-2938
1966
Sus scrofa
Poulsen, L.L.; Sofer, S.S.; Ziegler, D.M.
Properties and applications of an immobilized mixed-function hepatic drug oxidase
Methods Enzymol.
44
849-856
1976
Sus scrofa
Ziegler, D.M.; Poulsen, L.L.
Hepatic microsomal mixed-function amine oxidase
Methods Enzymol.
52
142-151
1978
Sus scrofa
Poulsen, L.L.; Ziegler, D.M.
The liver microsomal FAD-containing monooxygenase. Spectral characterization and kinetic studies
J. Biol. Chem.
254
6449-6455
1979
Sus scrofa
Tynes, R.E.; Sabourin, P.J.; Hodgson, E.
Identification of distinct hepatic and pulmonary forms of microsomal flavin-containing monooxygenase in the mouse and rabbit
Biochem. Biophys. Res. Commun.
126
1069-1075
1985
Oryctolagus cuniculus, Mus musculus
Prough, R.A.; Freeman, P.C.; Hines, R.N.
The oxidation of hydrazine derivatives catalyzed by the purified liver microsomal FAD-containing monooxygenase
J. Biol. Chem.
256
4178-4184
1981
Mesocricetus auratus, Rattus norvegicus, Sus scrofa
Beaty, N.B.; Ballou, D.P.
The reductive half-reaction of liver microsomal FAD-containing monooxygenase
J. Biol. Chem.
256
4611-4618
1981
Sus scrofa
Beaty, N.B.; Ballou, D.P.
The oxidative half-reaction of liver microsomal FAD-containing monooxygenase
J. Biol. Chem.
256
4619-4625
1981
Sus scrofa
Guan, S.; Falick, A.M.; Williams, D.E.; Cashman, J.R.
Evidence for complex formation between rabbit lung flavin-containing monooxygenase and calreticulin
Biochemistry
30
9892-9900
1991
Oryctolagus cuniculus
Gasser, R.; Tynes, R.E.; Lawton, M.P.; Korsmeyer, K.K.; Ziegler, D.M.; Philpot, R.M.
The flavin-containing monooxygenase expressed in pig liver: primary sequence, distribution, and evidence for a single gene
Biochemistry
29
119-124
1990
Sus scrofa
Lawton, M.P.; Gasser, R.; Tynes, R.E.; Hodgson, E.; Philpot, R.M.
The flavin-containing monooxygenase enzymes expressed in rabbit liver and lung are products of related but distinctly different genes
J. Biol. Chem.
265
5855-5861
1990
Oryctolagus cuniculus
Yamada, H.; Yuno, K.; Oguri, K.; Yoshimura, H.
Multiplicity of liver microsomal flavin-containing monooxygenase in the guinea pig: its purification and characterization
Arch. Biochem. Biophys.
280
305-312
1990
Cavia porcellus
Tynes, R.E.; Hodgson, E.
Catalytic activity and substrate specificity of the flavin-containing monooxygenase in microsomal systems: characterization of the hepatic, pulmonary and renal enzymes of the mouse, rabbit, and rat
Arch. Biochem. Biophys.
240
77-93
1985
Oryctolagus cuniculus, Mus musculus, Rattus norvegicus, Sus scrofa
Poulsen, L.L.; Hyslop, R.M.; Ziegler, D.M.
S-Oxygenation of N-substituted thioureas catalyzed by the pig liver microsomal FAD-containing monooxygenase
Arch. Biochem. Biophys.
198
78-88
1979
Mesocricetus auratus, Sus scrofa
Paterson, J.R.; Hood, H.T.; Skellern, G.G.
The role of porcine thyroid peroxidase and FAD-containing monooxygenase in the metabolism of 1-methyl-2-thioimidazole (methimazole)
Biochem. Biophys. Res. Commun.
116
449-455
1983
Sus scrofa
Wu, R.F.; Ichikawa, Y.
An essential lysyl residue (Lys208) in the substrate-binding site of porcine FAD-containing monooxygenase
Eur. J. Biochem.
229
749-753
1995
Sus scrofa
Schlenk, D.; Li-Schlenk, R.
Characterization of liver flavin-containing monooxygenase of the dogfish shark (Squalus acanthias) and partial purification of liver flavin-containing monooxygenase of the silky shark (Carcharhinus falciformis)
Comp. Biochem. Physiol. B
109
655-664
1994
Carcharhinus falciformis, Squalus acanthias
Cashman, J.R.; Xiong, Y.; Lin, J.; Verhagen, H.; van Poppel, G.; van Bladeren, P.J.; Larsen-Su, S.; Williams, D.
In vitro and in vivo inhibition of human flavin-containing monooxygenase form 3 (FMO3) in the presence of dietary indoles
Biochem. Pharmacol.
58
1047-1055
1999
Homo sapiens
Kawaji, A.; Miki, T.; Takabatake, E.
Partial purification and substrate specificity of flavin-containing monooxygenase from rat brain microsomes
Biol. Pharm. Bull.
18
1657-1659
1995
Rattus norvegicus
Overby, L.H.; Buckpitt, A.R.; Lawton, M.P.; Atta-Asafo-Adjei, E.; Schulze, J.; Philpot, R.M.
Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog
Arch. Biochem. Biophys.
317
275-284
1995
Cavia porcellus, Homo sapiens
Wu, R.F.; Ichikawa, Y.
Characteristic properties and kinetic analysis with neurotoxins of porcine FAD-containing monooxygenase
Biochim. Biophys. Acta
1208
204-210
1994
Sus scrofa
Sadeque, A.J.M.; Thummel, K.E.; Rettie, A.E.
Purification of macacque liver flavin-containing monooxygenase: A form of the enzyme related immunochemically to an isoenzyme expressed selectively in adult human liver
Biochim. Biophys. Acta
1162
127-134
1993
Macaca fascicularis
Clement, B.; Weide, M.; Ziegler, D.M.
Inhibition of purified and membrane-bound flavin-containing monooxygenase 1 by (N,N-dimethylamino)stilbene carboxylates
Chem. Res. Toxicol.
9
599-604
1996
Sus scrofa
Dolphin, C.T.; Janmohamed, A.; Smith, R.L.; Shephard, E.A.; Phillips, I.R.
Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FMO3) gene in patients with fish-odour syndrome
Pharmacogenetics
10
799-807
2000
Homo sapiens
Peters, L.D.; Livingstone, D.R.; Shenin-Johnson, S.; Hines, R.N.; Schlenk, D.
Characterization of hepatic flavin monooxygenase from the marine teleost turbot (Scophthalmus maximus L.)
Xenobiotica
25
121-131
1995
Scophthalmus maximus
Adali, O.; Carver, G.C.; Philpot, R.M.
The effect of arginine-428 mutation on modulation of activity of human liver flavin monooxygenase 3 (FMO3) by imipramine and chlorpromazine
Exp. Toxicol. Pathol.
51
271-276
1999
Homo sapiens
Cashman, J.R.
Human flavin-containing monooxygenase: substrate specificity and role in drug metabolism
Curr. Drug Metab.
1
181-191
2000
Homo sapiens
Overby, L.H.; Carver, G.C.; Philpot, R.M.
Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans
Chem. Biol. Interact.
106
29-45
1997
Homo sapiens
Lattard, V.; Buronfosse, T.; Lachuer, J.; Longin-Sauvageon, C.; Moulin, C.; Benoit, E.
Cloning, sequencing, tissue distribution, and heterologous expression of rat flavin-containing monooxygenase 3
Arch. Biochem. Biophys.
391
30-40
2001
Rattus norvegicus
Sumizu, K.
Oxidation of hypotaurine in rat liver
Biochim. Biophys. Acta
63
210 - 212
1962
Rattus norvegicus
Chiba, K.; Kubota, E.; Miyakawa, T.; Kato, Y.; Ishizaki, T.
Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice
J. Pharmacol. Exp. Ther.
246
1108-1115
1988
Mus musculus, Mus musculus C-57 BL
Chiba, K.; Kobayashi, K.; Itoh, K.; Itoh, S.; Chiba, T.; Ishizaki, T.; Kamataki, T.
N-oxygenation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by the rat liver flavin-containing monooxygenase expressed in yeast cells
Eur. J. Pharmacol.
293
97-100
1995
Rattus norvegicus
Di Monte, D.A.; Wu, E.Y.; Irwin, I.; Delanney, L.E.; Langston, J.W.
Biotransformation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes
J. Pharmacol. Exp. Ther.
258
594-600
1991
Mus musculus
Tsutsumi, H.; Katagi, M.; Nishikawa, M.; Tsuchihashi, H.; Kasuya, F.; Igarashi, K.
In vitro confirmation of selegiline N-oxidation by flavin-containing monooxygenase in rat microsome using LC-ESI MS
Biol. Pharm. Bull.
27
1572-1575
2004
Rattus norvegicus
Reid, J.M.; Walker, D.L.; Miller, J.K.; Benson, L.M.; Tomlinson, A.J.; Naylor, S.; Blajeski, A.L.; LoRusso, P.M.; Ames, M.M.
The metabolism of pyrazoloacridine (NSC 366140) by cytochromes P450 and flavin monooxygenase in human liver microsomes
Clin. Cancer Res.
10
1471-1480
2004
Homo sapiens
Raza, H.; Bhagwat, S.V.; John, A.
Flavin-containing monooxygenase activity in camel tissues: comparison with rat and human liver enzymes
Comp. Biochem. Physiol. C
139
289-293
2004
Camelus dromedarius
Lee, J.K.; Kang, J.H.; Cha, Y.N.; Chung, W.G.; Park, C.S.
Alteration of substrate specificity by common variants, E158K/E308G and V257M, in human hepatic drug-metabolizing enzyme, flavin-containing monooxygenase 3
Korean J. Physiol. Pharmacol.
7
157-162
2003
Homo sapiens
-
Wu, R.F.; Liao, C.X.; Tomita, S.; Ichikawa, Y.; Terada, L.S.
Porcine FAD-containing monooxygenase metabolizes lidocaine, bupivacaine and propranolol in vitro
Life Sci.
75
1011-1019
2004
Sus scrofa
Ryu, S.D.; Yi, H.G.; Cha, Y.N.; Kang, J.H.; Kang, J.S.; Jeon, Y.C.; Park, H.K.; Yu, T.M.; Lee, J.N.; Park, C.S.
Flavin-containing monooxygenase activity can be inhibited by nitric oxide-mediated S-nitrosylation
Life Sci.
75
2559-2572
2004
Homo sapiens
Schlenk, D.; Yeung, C.; Rettie, A.
Unique monooxygenation pattern indicates novel flavin-containing monooxygenase in liver of rainbow trout
Mar. Environ. Res.
58
499-503
2004
Oncorhynchus mykiss
Stevens, J.C.; Melton, R.J.; Zaya, M.J.; Engel, L.C.
Expression and characterization of functional dog flavin-containing monooxygenase 1
Mol. Pharmacol.
63
271-275
2003
Canis lupus familiaris, Homo sapiens
Furnes, B.; Schlenk, D.
Evaluation of xenobiotic N- and S-oxidation by variant flavin-containing monooxygenase 1 (FMO1) enzymes
Toxicol. Sci.
78
196-203
2004
Homo sapiens
Krueger, S.K.; Siddens, L.K.; Henderson, M.C.; VanDyke, J.E.; Karplus, P.A.; Pereira, C.B.; Williams, D.E.
C-terminal truncation of rabbit flavin-containing monooxygenase isoform 2 enhances solubility
Arch. Biochem. Biophys.
450
149-156
2006
Oryctolagus cuniculus (P17635), Oryctolagus cuniculus
Cashman, J.R.
Some distinctions between flavin-containing and cytochrome P450 monooxygenases
Biochem. Biophys. Res. Commun.
338
599-604
2005
Homo sapiens
Moore, I.F.; Hughes, D.W.; Wright, G.D.
Tigecycline is modified by the flavin-dependent monooxygenase TetX
Biochemistry
44
11829-11835
2005
Bacteroides fragilis
Elfarra, A.A.; Krause, R.J.
Potential roles of flavin-containing monooxygenases in sulfoxidation reactions of L-methionine, N-acetyl-L-methionine and peptides containing L-methionine
Biochim. Biophys. Acta
1703
183-189
2005
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Rasooly, R.; Kelley, D.S.; Greg, J.; Mackey, B.E.
Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver
Br. J. Nutr.
97
58-66
2007
Mus musculus
Demirdoegen, B.C.; Adali, O.
Characterization and modulation by drugs of sheep liver microsomal flavin monooxygenase activity
Cell Biochem. Funct.
23
245-251
2005
Ovis aries
Qian, L.; Ortiz de Montellano, P.R.
Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3
Chem. Res. Toxicol.
19
443-449
2006
Homo sapiens, Mycobacterium tuberculosis
Parte, P.; Kupfer, D.
Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin
Drug Metab. Dispos.
33
1446-1452
2005
Homo sapiens
Furnes, B.; Schlenk, D.
Extrahepatic metabolism of carbamate and organophosphate thioether compounds by the flavin-containing monooxygenase and cytochrome P450 systems
Drug Metab. Dispos.
33
214-218
2005
Homo sapiens
Borbas, T.; Zhang, J.; Cerny, M.A.; Liko, I.; Cashman, J.R.
Investigation of structure and function of a catalytically efficient variant of the human flavin-containing monooxygenase form 3
Drug Metab. Dispos.
34
1995-2002
2006
Homo sapiens
Shimizu, M.; Yano, H.; Nagashima, S.; Murayama, N.; Zhang, J.; Cashman, J.R.; Yamazaki, H.
Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities
Drug Metab. Dispos.
35
328-330
2007
Homo sapiens
Krueger, S.K.; Vandyke, J.E.; Williams, D.E.; Hines, R.N.
The role of flavin-containing monooxygenase (FMO) in the metabolism of tamoxifen and other tertiary amines
Drug Metab. Rev.
38
139-147
2006
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Borbas, T.; Benko, B.; Dalmadi, B.; Szabo, I.; Tihanyi, K.
Insulin in flavin-containing monooxygenase regulation. Flavin-containing monooxygenase and cytochrome P450 activities in experimental diabetes
Eur. J. Pharm. Sci.
28
51-58
2006
Rattus norvegicus
Vyas, P.M.; Roychowdhury, S.; Koukouritaki, S.B.; Hines, R.N.; Krueger, S.K.; Williams, D.E.; Nauseef, W.M.; Svensson, C.K.
Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: II. Expression and role of flavin-containing monooxygenases and peroxidases
J. Pharmacol. Exp. Ther.
319
497-505
2006
Homo sapiens (Q01740)
Koukouritaki, S.B.; Poch, M.T.; Henderson, M.C.; Siddens, L.K.; Krueger, S.K.; VanDyke, J.E.; Williams, D.E.; Pajewski, N.M.; Wang, T.; Hines, R.N.
Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants
J. Pharmacol. Exp. Ther.
320
266-273
2007
Homo sapiens
Zhou, J.; Shephard, E.A.
Mutation, polymorphism and perspectives for the future of human flavin-containing monooxygenase 3
Mutat. Res.
612
165-171
2006
Homo sapiens
Krueger, S.K.; Williams, D.E.
Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism
Pharmacol. Ther.
106
357-387
2005
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Sus scrofa
Bartsch, M.; Gobbato, E.; Bednarek, P.; Debey, S.; Schultze, J.L.; Bautor, J.; Parker, J.E.
Salicylic acid-independent enhanced disease susceptibility1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7
Plant Cell
18
1038-1051
2006
Arabidopsis thaliana (Q9LMA1), Arabidopsis thaliana
Koch, M.; Vorwerk, S.; Masur, C.; Sharifi-Sirchi, G.; Olivieri, N.; Schlaich, N.L.
A role for a flavin-containing mono-oxygenase in resistance against microbial pathogens in Arabidopsis
Plant J.
47
629-639
2006
Arabidopsis thaliana
Mishina, T.E.; Zeier, J.
The Arabidopsis flavin-dependent monooxygenase FMO1 is an essential component of biologically induced systemic acquired resistance
Plant Physiol.
141
1666-1675
2006
Arabidopsis thaliana
Eswaramoorthy, S.; Bonanno, J.B.; Burley, S.K.; Swaminathan, S.
Mechanism of action of a flavin-containing monooxygenase
Proc. Natl. Acad. Sci. USA
103
9832-9837
2006
Schizosaccharomyces pombe (Q9HFE4), Schizosaccharomyces pombe
Yeung, C.K.; Adman, E.T.; Rettie, A.E.
Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria
Arch. Biochem. Biophys.
464
251-259
2007
Homo sapiens
Shephard, E.A.; Chandan, P.; Stevanovic-Walker, M.; Edwards, M.; Phillips, I.R.
Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse
Biochem. J.
406
491-499
2007
Mus musculus (P50285), Mus musculus, Homo sapiens (Q01740), Homo sapiens
Siddens, L.K.; Henderson, M.C.; Vandyke, J.E.; Williams, D.E.; Krueger, S.K.
Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms
Biochem. Pharmacol.
75
570-579
2008
Mus musculus
Klick, D.E.; Shadley, J.D.; Hines, R.N.
Differential regulation of human hepatic flavin containing monooxygenase 3 (FMO3) by CCAAT/enhancer-binding protein beta (C/EBPbeta) liver inhibitory and liver activating proteins
Biochem. Pharmacol.
76
268-278
2008
Homo sapiens (P31513), Homo sapiens
Phillips, I.R.; Francois, A.A.; Shephard, E.A.
The flavin-containing monooxygenases (FMOs): genetic variation and its consequences for the metabolism of therapeutic drugs
Curr. Pharmacogenomics
5
292-313
2007
Homo sapiens (P31512), Homo sapiens (P31513), Homo sapiens (P49326), Homo sapiens (Q01740), Homo sapiens (Q99518)
-
Kousba, A.; Soll, R.; Yee, S.; Martin, M.
Cyclic conversion of the novel Src kinase inhibitor [7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-oxide metabolite by flavin-containing monoxygenases and cytochrome P450 reduct
Drug Metab. Dispos.
35
2242-2251
2007
Homo sapiens
Yanni, S.B.; Annaert, P.P.; Augustijns, P.; Bridges, A.; Gao, Y.; Benjamin, D.K.; Thakker, D.R.
Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes
Drug Metab. Dispos.
36
1119-1125
2008
Homo sapiens
Shimizu, M.; Tomioka, S.; Murayama, N.; Yamazaki, H.
Missense and nonsense mutations of the flavin-containing monooxygenase 3 gene in a Japanese cohort
Drug Metab. Pharmacokinet.
22
61-64
2007
Homo sapiens (P31513)
Zhang, J.; Cerny, M.A.; Lawson, M.; Mosadeghi, R.; Cashman, J.R.
Functional activity of the mouse flavin-containing monooxygenase forms 1, 3, and 5
J. Biochem. Mol. Toxicol.
21
206-215
2007
Mus musculus
Allerston, C.K.; Shimizu, M.; Fujieda, M.; Shephard, E.A.; Yamazaki, H.; Phillips, I.R.
Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3)
Pharmacogenet. Genomics
17
827-839
2007
Homo sapiens (P31513), Homo sapiens
Alfieri, A.; Malito, E.; Orru, R.; Fraaije, M.W.; Mattevi, A.
Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase
Proc. Natl. Acad. Sci. USA
105
6572-6577
2008
Methylophaga aminisulfidivorans, Methylophaga aminisulfidivorans SK1
Phillips, I.R.; Shephard, E.A.
Flavin-containing monooxygenases: mutations, disease and drug response
Trends Pharmacol. Sci.
29
294-301
2008
Saccharomyces cerevisiae, Homo sapiens (P31513), Homo sapiens (Q01740), Homo sapiens (Q99518), Homo sapiens
Mitchell, S.
Flavin mono-oxygenase (FMO) - The other oxidase
Curr. Drug Metab.
9
280-284
2008
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Rodriguez-Fuentes, G.; Aparicio-Fabre, R.; Li, Q.; Schlenk, D.
Osmotic regulation of a novel flavin-containing monooxygenase in primary cultured cells from rainbow trout (Oncorhynchus mykiss)
Drug Metab. Dispos.
36
1212-1217
2008
Oncorhynchus mykiss (A0SZ82), Oncorhynchus mykiss
Novick, R.M.; Elfarra, A.A.
Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes
Drug Metab. Dispos.
36
2468-2474
2008
Rattus norvegicus (Q9EQ76)
Francois, A.A.; Nishida, C.R.; de Montellano, P.R.; Phillips, I.R.; Shephard, E.A.
Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide
Drug Metab. Dispos.
37
178-186
2009
Homo sapiens (Q01740), Homo sapiens
Krueger, S.K.; Henderson, M.C.; Siddens, L.K.; VanDyke, J.E.; Benninghoff, A.D.; Karplus, P.A.; Furnes, B.; Schlenk, D.; Williams, D.E.
Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K
Drug Metab. Dispos.
37
1785-1791
2009
Homo sapiens (Q99518), Homo sapiens
Lickteig, A.J.; Riley, R.; Melton, R.J.; Reitz, B.A.; Fischer, H.D.; Stevens, J.C.
Expression and characterization of functional dog flavin-containing monooxygenase 3
Drug Metab. Dispos.
37
1987-1990
2009
Canis lupus familiaris, Homo sapiens
Zhang, J.; Chaluvadi, M.R.; Reddy, R.; Motika, M.S.; Richardson, T.A.; Cashman, J.R.; Morgan, E.T.
Hepatic flavin-containing monooxygenase gene regulation in different mouse inflammation models
Drug Metab. Dispos.
37
462-468
2009
Mus musculus
Cashman, J.R.; Zhang, J.; Nelson, M.R.; Braun, A.
Analysis of flavin-containing monooxygenase 3 genotype data in populations administered the anti-schizophrenia agent olanzapine
Drug Metab. Lett.
2
100-114
2008
Homo sapiens (P31513), Homo sapiens
Hai, X.; Adams, E.; Hoogmartens, J.; Van Schepdael, A.
Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms
Electrophoresis
30
1248-1257
2009
Homo sapiens
Novick, R.M.; Mitzey, A.M.; Brownfield, M.S.; Elfarra, A.A.
Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes
J. Pharmacol. Exp. Ther.
329
1148-1155
2009
Homo sapiens, Homo sapiens (P31512), Mus musculus, Rattus norvegicus (P36365), Rattus norvegicus (Q8K4B7), Rattus norvegicus (Q9EQ76)
Gao, Q.; Gao, F.; Wang, R.; Zhang, J.
Molecular cloning, expression, and polyclonal antibody production of a novel flavin-containing monooxygenase from Thellungiella halophila
Plant Mol. Biol. Rep.
27
94-101
2009
Eutrema halophilum (A0FIZ7)
-
Henderson, M.C.; Siddens, L.K.; Morre, J.T.; Krueger, S.K.; Williams, D.E.
Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes
Toxicol. Appl. Pharmacol.
233
420-427
2008
Homo sapiens, Homo sapiens (Q01740), Homo sapiens (Q99518), Mus musculus, Mus musculus (P50285), Mus musculus (Q8K2I3)
Aktas, D.; Can Demirdgen, B.; Adali, O.
Metabolism of methimazole by bovine liver microsomal flavine monooxygenase: modulation by imipramine and chlorpromazine, comparison with sheep enzyme
Turk. J. Biochem.
34
44-50
2009
Bos taurus
-
Lee, S.K.; Kang, M.J.; Jin, C.; In, M.K.; Kim, D.H.; Yoo, H.H.
Flavin-containing monooxygenase 1-catalysed N,N-dimethylamphetamine N-oxidation
Xenobiotica
39
680-686
2009
Homo sapiens (Q01740), Homo sapiens
Castrignano, S.; Sadeghi, S.J.; Gilardi, G.
Electro-catalysis by immobilised human flavin-containing monooxygenase isoform 3 (hFMO3)
Anal. Bioanal. Chem.
398
1403-1409
2010
Homo sapiens
Novick, R.; Vezina, C.; Elfarra, A.
Isoform distinct time-, dose-, and castration-dependent alterations in flavin-containing monooxygenase expression in mouse liver after 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
Biochem. Pharmacol.
79
1345-1351
2010
Mus musculus (P50285), Mus musculus (P97501), Mus musculus (P97872), Mus musculus (Q8K2I3), Mus musculus (Q8VHG0), Mus musculus, Mus musculus C57/BL6J (P50285), Mus musculus C57/BL6J (P97501), Mus musculus C57/BL6J (P97872), Mus musculus C57/BL6J (Q8K2I3), Mus musculus C57/BL6J (Q8VHG0)
Driscoll, J.P.; Aliagas, I.; Harris, J.J.; Halladay, J.S.; Khatib-Shahidi, S.; Deese, A.; Segraves, N.; Khojasteh-Bakht, S.C.
Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination
Chem. Res. Toxicol.
23
861-863
2010
Homo sapiens
Reddy, R.R.; Ralph, E.C.; Motika, M.S.; Zhang, J.; Cashman, J.R.
Characterization of human flavin-containing monooxygenase (FMO) 3 and FMO5 expressed as maltose-binding protein fusions
Drug Metab. Dispos.
38
2239-2245
2010
Homo sapiens
Capolongo, F.; Santi, A.; Anfossi, P.; Montesissa, C.
Benzydamine as a useful substrate of hepatic flavin-containing monooxygenase activity in veterinary species
J. Vet. Pharmacol. Ther.
33
341-346
2010
Bos taurus, Oryctolagus cuniculus, Sus scrofa
Rioz-Martinez, A.; Kopacz, M.; de Gonzalo, G.; Torres Pazmino, D.E.; Gotor, V.; Fraaije, M.W.
Exploring the biocatalytic scope of a bacterial flavin-containing monooxygenase
Org. Biomol. Chem.
9
1337-1341
2011
Methylophaga sp., Methylophaga sp. SK1
Celius, T.; Pansoy, A.; Matthews, J.; Okey, A.B.; Henderson, M.C.; Krueger, S.K.; Williams, D.E.
Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver
Toxicol. Appl. Pharmacol.
247
60-69
2010
Mus musculus (P97501), Mus musculus
Lang, D.H.; Yeung, C.K.; Peter, R.M.; Ibarra, C.; Gasser, R.; Itagaki, K.; Philpot, R.M.; Rettie, A.E.
Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3
Biochem. Pharmacol.
56
1005-1012
1998
Homo sapiens (Q01740), Homo sapiens
Fedejko-Kap, B.; Niemira, M.; Radominska-Pandya, A.; Mazerska, Z.
Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells
Xenobiotica
41
1044-1055
2011
Rattus norvegicus, Homo sapiens (Q01740), Homo sapiens (Q9HA79), Homo sapiens
Han, A.; Robinson, R.M.; Badieyan, S.; Ellerbrock, J.; Sobrado, P.
Tryptophan-47 in the active site of Methylophaga sp. strain SK1 flavin-monooxygenase is important for hydride transfer
Arch. Biochem. Biophys.
532
46-53
2013
Methylophaga sp., Methylophaga sp. SK1
Motika, M.S.; Zhang, J.; Ralph, E.C.; Dwyer, M.A.; Cashman, J.R.
pH dependence on functional activity of human and mouse flavin-containing monooxygenase 5
Biochem. Pharmacol.
83
962-968
2012
Homo sapiens (P49326), Homo sapiens, Mus musculus (P97872), Mus musculus
Uno, Y.; Shimizu, M.; Yamazaki, H.
Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque
Biochem. Pharmacol.
85
1837-1847
2013
Macaca fascicularis (KC734478), Macaca fascicularis (KC734481), Macaca fascicularis (KC734482), Macaca fascicularis (KC734486), Macaca fascicularis
Cho, H.J.; Cho, H.Y.; Kim, K.J.; Kim, M.H.; Kim, S.W.; Kang, B.S.
Structural and functional analysis of bacterial flavin-containing monooxygenase reveals its ping-pong-type reaction mechanism
J. Struct. Biol.
175
39-48
2011
Methylophaga aminisulfidivorans (Q83XK4), Methylophaga aminisulfidivorans SK1 (Q83XK4)
Huang, L.; Romero, E.; Ressmann, A.; Rudroff, F.; Hollmann, F.; Fraaije, M.; Kara, S.
Nicotinamide adenine dinucleotide-dependent redox-neutral convergent cascade for lactonizations with type II flavin-containing monooxygenase
Adv. Synth. Catal.
359
2142-2148
2017
Rhodococcus jostii
-
Catucci, G.; Polignano, I.; Cusumano, D.; Medana, C.; Gilardi, G.; Sadeghi, S.J.
Identification of human flavin-containing monooxygenase 3 substrates by a colorimetric screening assay
Anal. Biochem.
522
46-52
2017
Homo sapiens
Huijbers, M.; Montersino, S.; Westphal, A.; Tischler, D.; Van Berkel, W.
Flavin dependent monooxygenases
Arch. Biochem. Biophys.
544
2-17
2014
Homo sapiens
-
Wicht, D.K.
The reduced flavin-dependent monooxygenase SfnG converts dimethylsulfone to methanesulfinate
Arch. Biochem. Biophys.
604
159-166
2016
Pseudomonas fluorescens, Pseudomonas fluorescens Pf0-1
Siddens, L.K.; Krueger, S.K.; Henderson, M.C.; Williams, D.E.
Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide
Biochem. Pharmacol.
89
141-147
2014
Homo sapiens
Ameria, S.P.; Jung, H.S.; Kim, H.S.; Han, S.S.; Kim, H.S.; Lee, J.H.
Characterization of a flavin-containing monooxygenase from Corynebacterium glutamicum and its application to production of indigo and indirubin
Biotechnol. Lett.
37
1637-1644
2015
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC13032
Saraav, I.; Pandey, K.; Misra, R.; Singh, S.; Sharma, M.; Sharma, S.
Characterization of MymA protein as a flavin-containing monooxygenase and as a target of isoniazid
Chem. Biol. Drug Des.
89
152-160
2017
Mycobacterium tuberculosis
Phillips, I.R.; Francois, A.A.; Shephard, E.A.
The flavin-containing monooxygenases (FMOs) genetic variation and its consequences for the metabolism of therapeutic drugs
Curr. Pharmacogenomics
5
292-313
2007
Homo sapiens
-
Uehara, S.; Uno, Y.; Inoue, T.; Murayama, N.; Shimizu, M.; Sasaki, E.; Yamazaki, H.
Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus)
Drug Metab. Dispos.
43
735-742
2015
Callithrix jacchus
Fennema, D.; Phillips, I.R.; Shephard, E.A.
Trimethylamine and trimethylamine N-oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease
Drug Metab. Dispos.
44
1839-1850
2016
Homo sapiens (P31513)
Tanino, T.; Bando, T.; Komada, A.; Nojiri, Y.; Okada, Y.; Ueda, Y.; Sakurai, E.
Hepatic flavin-containing monooxygenase 3 enzyme suppressed by type 1 allergy-produced nitric oxide
Drug Metab. Dispos.
45
1189-1196
2017
Mus musculus
Scott, F.; Gonzalez Malagon, S.G.; OBrien, B.A.; Fennema, D.; Veeravalli, S.; Coveney, C.R.; Phillips, I.R.; Shephard, E.A.
Identification of flavin-containing monooxygenase 5 (FMO5) as a regulator of glucose homeostasis and a potential sensor of gut bacteria
Drug Metab. Dispos.
45
982-989
2017
Mus musculus
Taniguchi-Takizawa, T.; Shimizu, M.; Kume, T.; Yamazaki, H.
Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans
Drug Metab. Pharmacokinet.
30
64-69
2015
Canis lupus familiaris, Homo sapiens, Macaca fascicularis, Rattus norvegicus
Phillips, I.R.; Shephard, E.A.
Drug metabolism by flavin-containing monooxygenases of human and mouse
Expert. Opin. Drug Metab. Toxicol.
13
167-181
2017
Homo sapiens, Mus musculus
Kong, W.; Li, J.; Yu, Q.; Cang, W.; Xu, R.; Wang, Y.; Ji, W.
Two novel flavin-containing monooxygenases involved in biosynthesis of aliphatic glucosinolates
Front. Plant Sci.
7
1292
2016
Arabidopsis thaliana
Pimviriyakul, P.; Thotsaporn, K.; Sucharitakul, J.; Chaiyen, P.
Kinetic mechanism of the dechlorinating flavin-dependent monooxygenase HadA
J. Biol. Chem.
292
4818-4832
2017
Ralstonia pickettii, Ralstonia pickettii DTP0602
Liao, B.M.; McManus, S.A.; Hughes, W.E.; Schmitz-Peiffer, C.
Flavin-containing monooxygenase 3 reduces endoplasmic reticulum stress in lipid-treated hepatocytes
Mol. Endocrinol.
30
417-428
2016
Homo sapiens, Mus musculus
Fu, C.W.; Lin, T.H.
Predicting the metabolic sites by flavin-containing monooxygenase on drug molecules using SVM classification on computed quantum mechanics and circular fingerprints molecular descriptors
PLoS ONE
12
e0169910
2017
Homo sapiens
El-Serafi, I.; Terelius, Y.; Abedi-Valugerdi, M.; Naughton, S.; Saghafian, M.; Moshfegh, A.; Mattsson, J.; Potacova, Z.; Hassan, M.
Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
PLoS ONE
12
e0187294
2017
Homo sapiens, Mus musculus
Bortolussi, S.; Catucci, G.; Gilardi, G.; Sadeghi, S.J.
N- and S-oxygenation activity of truncated human flavin-containing monooxygenase 3 and its common polymorphic variants
Arch. Biochem. Biophys.
697
108663
2021
Homo sapiens (P31513), Homo sapiens
Catucci, G.; Bortolussi, S.; Rampolla, G.; Cusumano, D.; Gilardi, G.; Sadeghi, S.J.
Flavin-containing monooxygenase 3 polymorphic variants significantly affect clearance of tamoxifen and clomiphene
Basic Clin. Pharmacol. Toxicol.
123
687-691
2018
Homo sapiens (P31513), Homo sapiens
Inoue, S.; Morita, R.; Minami, Y.
An indigo-producing plant, Polygonum tinctorium, possesses a flavin-containing monooxygenase capable of oxidizing indole
Biochem. Biophys. Res. Commun.
534
199-205
2021
Persicaria tinctoria
Cheropkina, H.; Catucci, G.; Marucco, A.; Fenoglio, I.; Gilardi, G.; Sadeghi, S.
Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate
Biochem. Pharmacol.
193
114763
2021
Homo sapiens (Q01740), Homo sapiens
Chen, M.; Guan, B.; Xu, H.; Yu, F.; Zhang, T.; Wu, B.
The molecular mechanism regulating diurnal rhythm of flavin-containing monooxygenase 5 in mouse liver
Drug Metab. Dispos.
47
1333-1342
2019
Mus musculus (P97872), Mus musculus, Mus musculus C57BL/6 (P97872)
Veeravalli, S.; Phillips, I.R.; Freire, R.T.; Varshavi, D.; Everett, J.R.; Shephard, E.A.
Flavin-containing monooxygenase 1 catalyzes the production of taurine from hypotaurine
Drug Metab. Dispos.
48
378-385
2020
Homo sapiens, Homo sapiens (Q01740), Mus musculus (P50285)
Hu, S.X.
Hepatic flavin-containing monooxygenase and aldehyde oxidase activities in male domestic pigs at different ages
Drug Metab. Lett.
12
125-131
2018
Sus scrofa
Shimizu, M.; Uehara, S.; Suemizu, H.; Yamazaki, H.
In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice
Drug Metab. Pharmacokinet.
37
100369
2021
Homo sapiens (P31513)
Taniguchi-Takizawa, T.; Kato, N.; Shimizu, M.; Kume, T.; Yamazaki, H.
Different substrate elimination rates of model drugs pH-dependently mediated by flavin-containing monooxygenases and cytochromes P450 in human liver microsomes
Drug Metab. Pharmacokinet.
40
100412
2021
Homo sapiens (P31513), Homo sapiens
Catucci, G.; Gao, C.; Rampolla, G.; Gilardi, G.; Sadeghi, S.J.
Uncoupled human flavin-containing monooxygenase 3 releases superoxide radical in addition to hydrogen peroxide
Free Radic. Biol. Med.
145
250-255
2019
Homo sapiens (P31513), Homo sapiens
Loncar, N.; van Beek, H.L.; Fraaije, M.W.
Structure-based redesign of a self-sufficient flavin-containing monooxygenase towards indigo production
Int. J. Mol. Sci.
20
6148
2019
Methylophaga sp.
Kim, J.; Lee, H.; Roh, Y.J.; Kim, H.U.; Shin, D.; Kim, S.; Son, J.; Lee, A.; Kim, M.; Park, J.; Hwang, S.Y.; Kim, K.; Lee, Y.K.; Jung, H.S.; Hwang, K.Y.; Lee, B.C.
Structural and kinetic insights into flavin-containing monooxygenase and calponin-homology domains in human MICAL3
IUCrJ
7
90-99
2020
Homo sapiens (P31513), Homo sapiens
Matsumoto, K.; Hasegawa, T.; Ohara, K.; Kamei, T.; Koyanagi, J.; Akimoto, M.
Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro
Xenobiotica
51
155-166
2021
Homo sapiens (P49326), Homo sapiens
html completed
