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Disease on EC 1.14.14.1 - unspecific monooxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
17alpha-hydroxyprogesterone deacetylase deficiency
A 5'-splice site mutation in the cytochrome P450 steroid 17alpha-hydroxylase gene in 17alpha-hydroxylase deficiency.
A Missense Mutation in the Human Cytochrome b5 Gene causes 46,XY Disorder of Sex Development due to True Isolated 17,20 Lyase Deficiency.
Aberrant Crypt Foci
CYP27A1 and CYP24 expression as a function of malignant transformation in the colon.
Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.
Role of Hepatic and Intestinal P450 Enzymes in the Metabolic Activation of the Colon Carcinogen Azoxymethane in Mice.
[Effects of astragalosides on induction of colorectal aberrant crypt foci by dimethylhydrazine and metabolizing enzymes in liver microsomes in rats]
Abortion, Habitual
Role of CYP17 and CYP19 polymorphisms in idiopathic recurrent miscarriages among South Indian women.
Abortion, Spontaneous
Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not involved in the risk of recurrent pregnancy loss.
Altered decidual and placental catabolism of vitamin D may contribute to the aetiology of spontaneous miscarriage.
Association between LRH-1 single nucleotide polymorphisms and unexplained recurrent spontaneous abortion in Chinese Han couples.
Association of cytochrome P450 1B1 polymorphism with first-trimester miscarriage.
Caffeine metabolism and the risk of spontaneous abortion of normal karyotype fetuses.
Expression of CYP2D6 in developing human liver.
Rate of caffeine metabolism and risk of spontaneous abortion.
Achlorhydria
Long-term acid inhibition: benefits and harms.
Acidosis
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Acidosis, Lactic
[Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs].
Acidosis, Renal Tubular
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Acne Vulgaris
3,4,3',4'-Tetrachloro azoxybenzene and azobenzene: potent inducers of aryl hydrocarbon hydroxylase.
Aryl Hydrocarbon Receptor Activation in Acne Vulgaris Skin: A Case Series from the Region of Naples, Italy.
Association of the CYP17 MSP AI (T-34C) and CYP19 codon 39 (Trp/Arg) polymorphisms with susceptibility to acne vulgaris.
Gefitinib: new preparation. Non small-cell lung cancer: stricter assessment needed.
Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis.
Mild cutaneous manifestation in two young women with extraordinary hyperandrogenemia.
Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population.
Talarozole, a selective inhibitor of P450-mediated all-trans retinoic acid for the treatment of psoriasis and acne.
The P450 system and mTORC1-signaling in acne.
Acquired Immunodeficiency Syndrome
Altered pharmacokinetics and pharmacodynamics of repaglinide by ritonavir in rats with healthy, diabetic and impaired hepatic function.
Cost-effectiveness of CYP2B6 genotyping to optimize efavirenz dosing in HIV clinical practice.
Discordant Associations Between SLCO1B1 521T?C and Plasma Levels of Ritonavir-boosted Protease Inhibitors in AIDS Clinical Trials Group Study A5146.
Distribution of Polymorphisms in Cytochrome P450 2B6, Histocompatibility Complex P5, Chemokine Coreceptor 5, and Interleukin 28B Genes in Inhabitants from the Central Area of Argentina.
Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study.
Enzyme-substrate complementarity governs access to a cationic reaction manifold in the P450(BM3)-catalysed oxidation of cyclopropyl fatty acids.
Evidence for intraspecific endocrine disruption of Geukensia demissa (Atlantic ribbed mussel) in an urban watershed.
Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants.
Genotype and phenotype of cytochrome P450 2D6 in human immunodeficiency virus-positive patients and patients with acquired immunodeficiency syndrome.
Hydrogen-Bonded Dioxygen Adduct of an Iron Porphyrin with an Alkanethiolate Ligand: An Elaborate Model of Cytochrome P450 This research was supported by the Ministry of Education, Science, and Culture, Japan (Grant-in Aids #08CE2005, 09235225, and 11228207 to Y.N.) and through an Encouragement of Young Scientists stipendium (#08740500 to F.T.).
Long-enduring primary hepatocyte-based co-cultures improve prediction of hepatotoxicity.
NADPH-Cytochrome P450 Reductase Mediates the Resistance of Aphis (Toxoptera) citricidus (Kirkaldy) to Abamectin.
Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system.
Structure-activity relationship and in vitro inhibition of human cytochrome CYP2A6 and CYP2A13 by flavonoids.
[Perspective technologies for drug design]
Acute Coronary Syndrome
Association between cytochrome P450 2C19 polymorphism and clinical outcomes in clopidogrel-treated Uygur population with acute coronary syndrome: a retrospective study.
Clopidogrel versus Ticagrelor in CYP2C19 Loss-of-Function Allele Noncarriers: A Real-World Study in China.
Contribution of CYP27B1 and CYP24A1 Genetic Variations to the Incidence of Acute Coronary Syndrome and to Vitamin D Serum Level.
Correlation of CYP2D6 allelic polymorphism to outcome of acute coronary syndrome in mid-Euphrates Iraqi patients on metoprolol therapy.
Cost-effectiveness of cytochrome P450 2C19 *2 genotype-guided selection of clopidogrel or ticagrelor in Chinese patients with acute coronary syndrome.
Cost-Effectiveness of Multigene Pharmacogenetic Testing in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention.
CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndromes patients.
CYP2C19*17 May Increase the Risk of Death Among Patients with an Acute Coronary Syndrome and Non-Valvular Atrial Fibrillation Who Receive Clopidogrel and Rivaroxaban.
Cytochrome P450 CYP 2C19*2 Associated with Adverse 1-Year Cardiovascular Events in Patients with Acute Coronary Syndrome.
Economic Evaluations of CYP2C19 Genotype-Guided Antiplatelet Therapy Compared to the Universal Use of Antiplatelets in Patients With Acute Coronary Syndrome: A Systematic Review.
Effect of cytochrome P450 2C19 polymorphism on adverse cardiovascular events after drug-eluting stent implantation in a large Hakka population with acute coronary syndrome receiving clopidogrel in southern China.
Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome.
Effects of CYP2C19 allelic variants on inhibition of platelet aggregation and major adverse cardiovascular events in Japanese patients with acute coronary syndrome: The PRASFIT-ACS study.
Frequency of CYP3A4, CYP3A5, CYP2C9, and CYP2C19 variant alleles in patients receiving clopidogrel that experience repeat acute coronary syndrome.
Impact of CYP2C9 and VKORC1 genetic polymorphisms upon warfarin dose requirements in Egyptian patients with acute coronary syndrome.
Impact of Cytochrome P450 2C19*2 and *3 on Clopidogrel Loading Dose in Saudi Patients with Acute Coronary Syndrome.
microRNA-605 rs2043556 polymorphisms affect clopidogrel therapy through modulation of CYP2B6 and P2RY12 in acute coronary syndrome patients.
Platelet reactivity in the early and late phases of acute coronary syndromes according to cytochrome P450 2C19 phenotypes.
Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment.
Proton pump inhibitors and the risk of severe adverse events - A cardiovascular bombshell?
The ABCB1, CYP2C19, CYP3A5 and CYP4F2 genetic polymorphisms and platelet reactivity in the early phases of acute coronary syndromes.
The efficacy and safety of CYP2C19 genotype-guided antiplatelet therapy compared with conventional antiplatelet therapy in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: A meta-analysis of randomized controlled trials.
[Correlation between cytochrome 3A4+894C>T P450 gene polymorphism and outcomes of coronary intervention in patients with acute coronary syndrome].
[Resistance to antiplatelet drugs in patients with cerebrovascular disorders].
[Resistance to Antiplatelet Substances - a Real Clinical Problem.]
Acute Kidney Injury
A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury.
Acute kidney injury in patients with inactive cytochrome P450 polymorphisms.
Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s.
Analysis of the toxic effects of linoleic acid, 12,13-cis-epoxyoctadecenoic acid, and 12,13-dihydroxyoctadecenoic acid in rabbit renal cortical mitochondria.
beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism.
Clozapine-induced acute renal failure and cytochrome P450 genotype.
CYP2J2-produced epoxyeicosatrienoic acids attenuate ischemia/reperfusion-induced acute kidney injury by activating the SIRT1-FoxO3a pathway.
Down-regulation of hepatic cytochrome P450 enzymes associated with cisplatin-induced acute renal failure in male rats.
Effect of renal ischaemia/reperfusion-induced acute kidney injury on pharmacokinetics of midazolam in rats.
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of 2-(allylthio) pyrazine, a chemoprotective agent, in rats: the role of CYP3A23 induction.
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation.
Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats.
Effects of acute renal failure on the pharmacokinetics of telithromycin in rats: negligible effects of increase in CYP3A1 on the metabolism of telithromycin.
Effects of CYP3A5 polymorphism on the pharmacokinetics of a once-daily modified-release tacrolimus formulation and acute kidney injury in hematopoietic stem cell transplantation.
Effects of glucose on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.
Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.
Faster clearance of mirodenafil in rats with acute renal failure induced by uranyl nitrate: contribution of increased protein expression of hepatic CYP3A1 and intestinal CYP1A1 and 3A1/2.
Faster clearance of omeprazole in rats with acute renal failure induced by uranyl nitrate: contribution of increased expression of hepatic cytochrome P450 (CYP) 3A1 and intestinal CYP1A and 3A subfamilies.
Increase in urea in conjunction with L-arginine metabolism in the liver leads to induction of cytochrome P450 2E1 (CYP2E1): the role of urea in CYP2E1 induction by acute renal failure.
Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury.
Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury.
Pharmacogenomic associations in ABCB1 and CYP3A5 with acute kidney injury and chronic kidney disease after myeloablative hematopoietic cell transplantation.
Pharmacokinetic changes of drugs in rat model of acute renal failure induced by uranyl nitrate: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes.
Pharmacokinetic changes of intravenous 2-(allylthio) pyrazine, a chemoprotective agent, in rats with acute renal failure induced by uranyl nitrate.
Romidepsin (FK228) in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury is Associated with Down-Regulation of the CYP2E1 Gene.
The mechanism of cyclosporine toxicity induced by clarithromycin.
The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison.
Ticagrelor and Statin Interaction Induces Rhabdomyolysis and Acute Renal Failure: Case reports and Scoping Review.
Acute Lung Injury
Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-?B activation.
Modulation of Pulmonary Cytochrome P4501A1 Expression by Hyperoxia and Inhaled Nitric Oxide in the Newborn Rat: Implications for Lung Injury.
Acute-On-Chronic Liver Failure
Effects of plasma from patients with acute on chronic liver failure on function of cytochrome P450 in immortalized human hepatocytes.
Addison Disease
Adrenal-cortex autoantibodies and steroid-producing cells autoantibodies in patients with Addison's disease: comparison of immunofluorescence and immunoprecipitation assays.
Autoantibodies to adrenal cytochrome P450 antigens in isolated Addison's disease and autoimmune polyendocrine syndrome type II.
Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease.
Autoimmunity to steroid-producing cells and familial polyendocrine autoimmunity.
Identification of the main gonadal autoantigens in patients with adrenal insufficiency and associated ovarian failure.
Immunological cross-reactivity to multiple autoantigens in patients with liver kidney microsomal type 1 autoimmune hepatitis.
Mechanism of inhibition of cytochrome P450 C21 enzyme activity by autoantibodies from patients with Addison's disease.
Premature Ovarian Failure in Patients with Autoimmune Addison's Disease: Clinical, Genetic, and Immunological Evaluation.
Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease.
adenine phosphoribosyltransferase deficiency
Ultra-rare renal diseases diagnosed with whole-exome sequencing: Utility in diagnosis and management.
Adenocarcinoma
8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma.
A population-based, case-control study of polymorphisms in carcinogen-metabolizing genes, smoking, and pancreatic adenocarcinoma risk.
A practical method to determine the amount of tissue to analyze using laser scanning cytometry.
A specific African-American CYP1A1 polymorphism is associated with adenocarcinoma of the lung.
Altered regulation of the cytochrome P4501A1 gene: novel inducer-independent gene expression in pulmonary carcinoma cell lines.
Association of a genetic variant of CYP19A1 with multicentric development of lung adenocarcinomas.
Association of aryl hydrocarbon receptor and cytochrome P4501B1 expressions in human non-small cell lung cancers.
Association of cigarette smoking and CYP1A1 polymorphisms with adenocarcinoma of the lung by grades of differentiation.
Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells.
Bioinformatics and functional analyses of key genes in smoking-associated lung adenocarcinoma.
Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics.
Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer.
CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells.
CYP19 (aromatase cytochrome P450) gene expression in human malignant endometrial tumors.
CYP1A1 genetic polymorphisms and in situ colorectal cancer.
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.
CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population.
CYP1B1 Polymorphisms and K-ras Mutations in Patients with Pancreatic Ductal Adenocarcinoma.
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
CYP2D6 genotype and lung cancer risk according to histologic type and tobacco exposure.
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma.
Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development.
Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.
Cytochrome P450 expression (CYP) in non-small cell lung cancer.
Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism.
Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk.
Differential Expression of Cytochrome P450 Omega-hydroxylase Isoforms and Their Association with Clinicopathological Features in Pancreatic Ductal Adenocarcinoma.
Down-regulated expression of cytochrome P450 (CYP) involved in the development and progression of esophageal adenocarcinoma.
Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples.
Effects of cytochrome P450 (CYP) 2A6 gene deletion and CYP2E1 genotypes on gastric adenocarcinoma.
Evolution of Hominin Detoxification: Neanderthal and Modern Human Ah Receptor Respond Similarly to TCDD.
Features of the Copy Number Variation of Certain Genes in Tumor Cells in Patients with Serous Ovarian Adenocarcinoma.
Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County.
Genome-wide association study of familial lung cancer.
Glucocorticoid-induced pancreatic-hepatic trans-differentiation in a human cell line in vitro.
GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas.
GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.
Hypomethylation of the XRE -1383 site is associated with the upregulation of CYP1A1 in gastric adenocarcinoma.
Identification of key genes in endometrioid endometrial adenocarcinoma via TCGA database.
Immunohistochemical localization of cytochrome P450 2E1 in human pulmonary carcinoma and normal bronchial tissue.
Induction of cytochrome P450 1A1 gene expression by a vitamin K3 analog in mouse hepatoma Hepa-1c1c7 cells.
Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.
Lung cancer and CYP2D6 (the debrisoquine polymorphism): sources of heterogeneity in the proposed association.
Lung cancer risk in African-Americans in relation to a race-specific CYP1A1 polymorphism.
Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation.
Molecular epidemiology: a new perspective for the study of toxic exposures in man. A consideration of the influence of genetic susceptibility factors on risk in different lung cancer histologies.
No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.
Omeprazole induces NAD(P)H quinone oxidoreductase 1 via aryl hydrocarbon receptor-independent mechanisms: Role of the transcription factor nuclear factor erythroid 2-related factor 2.
Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct.
Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.
Overexpression of CYP2A6 in human colorectal tumors.
Overexpression of the heme oxygenase gene in renal cell carcinoma.
p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines.
Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.
Polymorphism of metabolizing genes and lung cancer histology: prevalence of CYP2E1 in adenocarcinoma.
Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma.
Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition.
Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.
Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma.
Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas.
Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas.
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Salvia fruticosa Modulates mRNA Expressions and Activity Levels of Xenobiotic Metabolizing CYP1A2, CYP2E1, NQO1, GPx, and GST Enzymes in Human Colorectal Adenocarcinoma HT-29 Cells.
Sulfated extract of Abelmoschus esculentus: A potential cancer chemopreventive agent.
Superoxide anions and other components of human renal adenocarcinoma.
Synergistic association of CYP1A1 polymorphisms with increased susceptibility to squamous cell lung cancer in north Indian smokers.
The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis.
The vitamin D system is deregulated in pancreatic diseases.
Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5'-upstream regions of these genes.
Transcriptional regulation of the human CYP1B1 gene. Evidence for involvement of an aryl hydrocarbon receptor response element in constitutive expression.
Transcriptome sequencing identifies key pathways and genes involved in gastric adenocarcinoma.
Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer.
Vitamin D metabolic pathway genes and pancreatic cancer risk.
Xenobiotic metabolising enzyme expression in colonic neoplasia.
Adenocarcinoma of Lung
8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population.
Analysis of genomic and transcriptomic variations as prognostic signature for lung adenocarcinoma.
Association between the CYP2E1 polymorphisms and lung cancer risk: a meta-analysis.
Association of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma: a case-control study in Chinese population.
Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers.
Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility.
CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis.
CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women.
CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma.
CYP3A5 suppresses metastasis of lung adenocarcinoma through ATOH8/Smad1 axis.
Cytochrome P4501A2 (CYP1A2) activity and lung cancer risk: a preliminary study among Chinese women in Singapore.
Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma.
Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5.
Induction of cytochromes P450 1A1 and 1B1 in human lung adenocarcinoma CL5 cells by frying-meat emission particulate.
Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans.
Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: an in vitro and in vivo study.
Oncogenic Potential of CYP24A1 in Lung Adenocarcinoma.
Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2.
Prognostic and therapeutic implications of aromatase expression in lung adenocarcinomas with EGFR mutations.
Regulation of CYP3A genes in the human respiratory tract.
Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells.
Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas.
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.
The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independently of its catalytic activity.
The expression levels of CYP3A4 and CYP3A5 serve as potential prognostic biomarkers in lung adenocarcinoma.
[Applications of aryl hydrocarbon hydroxylase in diagnosis of lung cancer]
Adenocarcinoma, Bronchiolo-Alveolar
Liposome mediated-CYP1A1 gene silencing nanomedicine prepared using lipid film-coated proliposomes as a potential treatment strategy of lung cancer.
Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas.
Adenocarcinoma, Mucinous
CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm.
Adenoma
8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenoma.
Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice.
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.
Aromatase cytochrome P450 enzyme expression in prolactinomas and its relationship to tumor behavior.
Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty.
Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma.
Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models.
Cigarette smoking, CYP1A1 MspI and GSTM1 genotypes, and colorectal adenomas.
CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma.
CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men.
CYP1A2 164 A-->C polymorphism, cigarette smoking, consumption of well-done red meat and risk of developing colorectal adenomas and carcinomas.
CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence.
CYP2C9 and UGT1A6 genotypes modulate the protective effect of aspirin on colon adenoma risk.
CYP2C9 variants increase risk of colorectal adenoma recurrence and modify associations with smoking but not aspirin treatment.
Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.
Cytochrome P450 2C9 Variants Influence Response to Celecoxib for Prevention of Colorectal Adenoma.
Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma.
Decreased levels of steroid 21-hydroxylase [P450(c21)] and its mRNA in an adrenocortical adenoma associated with 21-hydroxylase deficiency.
Diminished CYP2E1 expression and formation of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene epoxide, in murine lung tumors.
Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma.
Effects of ammonium perfluorooctanoate on Leydig cell function: in vitro, in vivo, and ex vivo studies.
Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria.
Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.
Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.
Genetic polymorphisms of CYP2E1 and risk of colorectal adenomas in the Self Defense Forces Health Study.
Genetic variants of UGT1A6 influence risk of colorectal adenoma recurrence.
Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.
GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp.
Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population.
Hyperparathyroidism complicating CYP 24A1 mutations.
Immunohistochemical detection of CYP2E1 and 2-S-glutathionyl acetate in murine lung tumors: diminished formation of reactive intermediates of 1,1-dichloroethylene.
Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: comparison of carcinogenicity and aryl hydrocarbon hydroxylase induction in the target organs of each species.
Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk.
Meat-derived carcinogens, genetic susceptibility and colorectal adenoma risk.
Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
Metabolic proficiency and benzo[a]pyrene DNA adduct formation in APCMin mouse adenomas and uninvolved mucosa.
Mild cutaneous manifestation in two young women with extraordinary hyperandrogenemia.
No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial.
Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.
Overexpression of CYP2A6 in human colorectal tumors.
Polymorphisms in heterocyclic aromatic amines metabolism-related genes are associated with colorectal adenoma risk.
Processed meat intake, CYP2A6 activity and risk of colorectal adenoma.
Resistance of murine lung tumors to xenobiotic-induced cytotoxicity.
The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis.
The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans.
The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice.
Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer.
Using a combination of cytochrome P450 1B1 and beta-catenin for early diagnosis and prevention of colorectal cancer.
Vitamin D Receptor Genotype, Vitamin D3 Supplementation, and Risk of Colorectal Adenomas: A Randomized Clinical Trial.
Xenobiotic metabolising enzyme expression in colonic neoplasia.
[How I was enticed into molecular toxicology]
Adenoma, Liver Cell
Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma.
Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis.
Adenoma, Pleomorphic
The role of aryl hydrocarbon receptor (AhR) in the pathology of pleomorphic adenoma in parotid gland.
Adenomatous Polyposis Coli
Cell lines from the same cervical carcinoma but with different radiosensitivities exhibit different cDNA microarray patterns of gene expression.
Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention against colorectal tumors in single Japanese cohort using daily low-dose aspirin: insights into future personalized treatments.
Phenotype of cytochrome P450 CYP2D6 in patients with familial adenomatous polyposis.
Adenomatous Polyps
CYP27A1 and CYP24 expression as a function of malignant transformation in the colon.
Adenomyosis
Adenomyosis: genetics of estrogen metabolism.
COMT 158G/A and CYP1B1 432C/G polymorphisms increase the risk of endometriosis and adenomyosis: a meta-analysis.
CYP17, CYP1A1 and COMT polymorphisms and the risk of adenomyosis and endometriosis in Taiwanese women.
Endometrial aromatase mRNA as a possible screening tool for advanced endometriosis and adenomyosis.
Estrogen degrades Scribble in endometrial epithelial cells through E3 ubiquitin ligase HECW1 in the development of diffuse adenomyosis†.
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium.
Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas.
High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome.
Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium.
[Role of estrogen, estrogen receptors, and aromatase in the pathogenesis of uterine adenomyosis].
Adenoviridae Infections
Chemical induced inflammation of the liver breaks tolerance and results in autoimmune hepatitis in Balb/c mice.
Evaluation of the HC-04 cell line as an in vitro model for mechanistic assessment of changes in hepatic cytochrome P450 3A during adenovirus infection.
Adrenal Hyperplasia, Congenital
17??hydroxylase/17,20?lyase deficiency in congenital adrenal hyperplasia: A case report.
21-Hydroxylase deficiency: from molecular genetics to clinical presentation.
A novel mutation in CYP17A1 gene leads to congenital adrenal hyperplasia: A case report.
A Three-dimensional Structure of Steroid 21-Hydroxylase (Cytochrome P450 21A2) with Two Substrates Reveals Locations of Disease-associated Variants.
Assisted Reproduction in Congenital Adrenal Hyperplasia.
Clinical presentation and mutational spectrum in a series of 166 patients with classical 21-hydroxylase deficiency from South China.
Congenital adrenal hyperplasia and the function of adrenal medulla.
Continuous subcutaneous hydrocortisone infusion (CSHI) in a young adolescent with congenital adrenal hyperplasia (CAH).
Frequent deletion and duplication of the steroid 21-hydroxylase genes.
Glucocorticoid-induced osteoporosis in children with 21-hydroxylase deficiency.
Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
Impact on CYP19A1 activity by mutations in NADPH cytochrome P450 oxidoreductase.
Junction site analysis of chimeric CYP21A1P/CYP21A2 genes in 21-hydroxylase deficiency.
Long-term outcome of partial P450 side-chain cleavage enzyme deficiency in three brothers: the importance of early diagnosis.
Low frequency of CYP2B deletions in Brazilian patients with congenital adrenal hyperplasia due to 21-hydroxylas deficiency.
Measuring the structural impact of mutations on cytochrome P450 21A2, the major steroid 21-hydroxylase related to congenital adrenal hyperplasia.
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
P450 side-chain cleavage deficiency--a rare cause of congenital adrenal hyperplasia.
Psychiatric manifestations in young females with congenital adrenal hyperplasia in Taiwan.
Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia.
Restoration of adrenal steroidogenesis by adenovirus-mediated transfer of human cytochromeP450 21-hydroxylase into the adrenal gland of21-hydroxylase-deficient mice.
Sequence analysis of CYP21A1P in a German population to aid in the molecular biological diagnosis of congenital adrenal hyperplasia.
Steroidogenic enzyme expression within the adrenal cortex during early human gestation.
Structure-phenotype correlations of human CYP21A2 mutations in congenital adrenal hyperplasia.
Two cases of 17?-hydroxylase/17,20-lyase deficiency caused by the CYP17A1 mutation.
Why is management of patients with classical congenital adrenal hyperplasia more difficult at puberty?
Adrenal Insufficiency
A novel entity of clinically isolated adrenal insufficiency caused by a partially inactivating mutation of the gene encoding for P450 side chain cleavage enzyme (CYP11A1).
Adrenal Insufficiency With Voriconazole and Inhaled/Intranasal Corticosteroids: Case Report and Systematic Review.
Delayed diagnosis of adrenal insufficiency in a patient with severe penoscrotal hypospadias due to two novel P450 side-change cleavage enzyme (CYP11A1) mutations (p.R360W; p.R405X).
Homozygous mutation of P450 side-chain cleavage enzyme gene (CYP11A1) in 46, XY patient with adrenal insufficiency, complete sex reversal, and agenesis of corpus callosum.
Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi.
Induction of cytochrome P450 2B1 in rat liver by the aromatase inhibitor aminoglutethimide.
Secondary adrenal insufficiency from steroid use and co-prescribing of cytochrome p450 3A4 inhibitors.
Adrenocortical Adenoma
Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma.
Adrenocortical Carcinoma
2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells.
2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity?
A case of renin-producing adrenocortical cancer.
Differential regulation of 3beta-hydroxysteroid dehydrogenase type II and 17alpha-hydroxylase/lyase P450 in human adrenocortical carcinoma cells by epidermal growth factor and basic fibroblast growth factor.
Effects of Neonicotinoids on Promoter-Specific Expression and Activity of Aromatase (CYP19) in Human Adrenocortical Carcinoma (H295R) and Primary Umbilical Vein Endothelial (HUVEC) Cells.
Estrogen biosynthesis in human H295 adrenocortical carcinoma cells.
Human Cytochrome P450 2W1 Is Not Expressed in Adrenal Cortex and Is Only Rarely Expressed in Adrenocortical Carcinomas.
Inhibition of human placental aromatase activity by hydroxylated polybrominated diphenyl ethers (OH-PBDEs).
Overexpression of cytochrome P450 2A6 in adrenocortical carcinoma.
Suppression of cytochrome P450 4B1: An early event in adrenocortical tumorigenesis.
Adrenogenital Syndrome
Biological aspects of cytochrome P450 and associated hydroxylation reactions.
Adrenoleukodystrophy
Case report of dysregulation of primary bile acid synthesis in a family with X-linked adrenoleukodystrophy.
Agenesis of Corpus Callosum
Homozygous mutation of P450 side-chain cleavage enzyme gene (CYP11A1) in 46, XY patient with adrenal insufficiency, complete sex reversal, and agenesis of corpus callosum.
Aggressive Periodontitis
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
Influence of CYP1A1 rs1048943 on Short- and Long-term Outcomes of Non-surgical Periodontal Therapy for Generalised Aggressive Periodontitis.
Agranulocytosis
NAT2 polymorphisms as a cause of metamizole-induced agranulocytosis.
Akathisia, Drug-Induced
SSRI-induced extrapyramidal side-effects and akathisia: implications for treatment.
Albinism
Fine mapping of a candidate gene for cool-temperature-induced albinism in ornamental kale.
alcohol dehydrogenase deficiency
Linking Dysregulated AMPK Signaling and ER Stress in Ethanol-Induced Liver Injury in Hepatic Alcohol Dehydrogenase Deficient Deer Mice.
Alcohol-Related Disorders
Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics.
Mutations in the exons and exon-intron junction regions of human cytochrome P-4502E1 gene and alcoholism.
Mutations in the Exons and Exon-Intron Junction Regions of Human Cytochrome P-4502E1 Gene and Alcoholism.
Alopecia
Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X.
Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6.
Relationship of Early-Onset Baldness to Prostate Cancer in African-American Men.
Altitude Sickness
The activity, protein, and mRNA expression of CYP2E1 and CYP3A1 in rats after exposure to acute and chronic high altitude hypoxia.
[Effect of high altitude hypoxia on the activity and protein expression of CYP2C9 and CYP2C19].
Alzheimer Disease
A review of smoking cessation: potentially risky effects on prescribed medications.
Alzheimer's disease: beware of interactions with cholinesterase inhibitors.
ApoE and CYP2D6 polymorphism with and without parkinsonism-dementia complex in the people of Chamorro, guam.
Association between rs10046, rs1143704, rs767199, rs727479, rs1065778, rs1062033, rs1008805, and rs700519 polymorphisms in aromatase (CYP19A1) gene and Alzheimer's disease risk: a systematic review and meta-analysis involving 11,051 subjects.
Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer's disease.
BCHE and CYP2D6 genetic variation in Alzheimer's disease patients treated with cholinesterase inhibitors.
Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer's disease.
Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease.
Cognitive Effects of Aromatase and Possible Role in Memory Disorders.
CYP19 haplotypes increase risk for Alzheimer's disease.
CYP2D6 gene polymorphism as a probable risk factor for Alzheimer's disease and Parkinson's disease with dementia.
CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease.
CYP2D6 polymorphisms in Alzheimer's disease, with and without extrapyramidal signs, showing no apolipoprotein E epsilon 4 effect modification.
Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.
Debrisoquine hydroxylase gene polymorphism frequencies in patients with amyotrophic lateral sclerosis.
Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Do CYP3A and ABCB1 genotypes influence the plasma concentration and clinical outcome of donepezil treatment?
Donepezil plasma concentrations, CYP2D6 and CYP3A4 phenotypes, and cognitive outcome in Alzheimer's disease.
Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease.
Effect of CYP2D6 and CYP3A4 Genotypes on the Efficacy of Cholinesterase Inhibitors in Southern Chinese Patients With Alzheimer's Disease.
Effect of the CYP2D6 and APOE Polymorphisms on the Efficacy of Donepezil in Patients with Alzheimer's Disease: A Systematic Review and Meta-Analysis.
Elevated hepatic and depressed renal cytochrome P450 activity in the Tg2576 transgenic mouse model of Alzheimer's disease.
Genetic variation of CYP19 (aromatase) gene influences age at onset of Alzheimer's disease in women.
Human Cognitive Ability Is Modulated by Aromatase Availability in the Brain in a Sex-Specific Manner.
Impact of CYP2D6 and CYP3A4 genetic polymorphism on combined cholinesterase inhibitors and memantine treatment in mild to moderate Alzheimer's disease.
Impact of CYP2D6, CYP3A5, and ABCB1 Polymorphisms on Plasma Concentrations of Donepezil and Its Metabolite in Patients With Alzheimer Disease.
Impact of the CYP2D6 polymorphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimer's disease patients.
Impact of the CYP2D6 single nucleotide polymorphism on the concentration of and therapeutic response to donepezil in mild-to-moderate Alzheimer's disease.
Influence of CYP2D6, CYP3A5, ABCB1, APOE polymorphisms and nongenetic factors on donepezil treatment in patients with Alzheimer's disease and vascular dementia.
Influence of rs1080985 single nucleotide polymorphism of the CYP2D6 gene on response to treatment with donepezil in patients with alzheimer's disease.
Influence of the rs1080985 Single Nucleotide Polymorphism of the CYP2D6 Gene and APOE Polymorphism on the Response to Donepezil Treatment in Patients with Alzheimer's Disease in China.
Interaction between CYP19 aromatase and butyrylcholinesterase genes increases Alzheimer's disease risk.
Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity.
No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population.
No association between familial Alzheimer disease and cytochrome P450 polymorphisms.
Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene.
Pharmacogenetic Aspects of Therapy with Cholinesterase Inhibitors: The Role of CYP2D6 in Alzheimer's Disease Pharmacogenetics.
Pharmacogenetic basis for therapeutic optimization in Alzheimer's disease.
Pharmacogenomic protocols in CNS disorders and dementia.
Pharmacogenomics and therapeutic prospects in Alzheimer's disease.
Plasma Lipids as Biomarkers for Alzheimer's Disease: A Systematic Review.
Polymorphic cytochromes P450 and drugs used in psychiatry.
Polymorphism in Cytochrome P450 2D6, Glutathione S-Transferases Pi 1 Genes, and Organochlorine Pesticides in Alzheimer Disease: A Case-Control Study in North Indian Population.
Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease.
Proteomics analyses for the global proteins in the brain tissues of different human prion diseases.
Quantitative assessment of CYP2D6 polymorphisms and risk of Alzheimer's disease: a meta-analysis.
Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism.
Rate of cognitive decline in Alzheimer's disease is not affected by the alpha-1-antichymotrypsin A allele or the CYP2D6 B mutant.
Regional and cellular distribution of CYP2D subfamily members in rat brain.
Replication study to confirm the role of CYP2D6 polymorphism rs1080985 on donepezil efficacy in Alzheimer's disease patients.
Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease.
Stereoselective metabolism of donepezil and steady-state plasma concentrations of S-donepezil based on CYP2D6 polymorphisms in the therapeutic responses of Han Chinese patients with Alzheimer's disease.
The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population.
The CYP2D6B allele is not overrepresented in a population of German patients with idiopathic Parkinson's disease.
The role of oestrogen in the pathogenesis of obesity, type 2 diabetes, breast cancer and prostate disease.
The roles of apolipoprotein E3 and CYP2D6 (rs1065852) gene polymorphisms in the predictability of responses to individualized therapy with donepezil in Han Chinese patients with Alzheimer's disease.
Variants in CYP17 and CYP19 cytochrome P450 genes are associated with onset of Alzheimer's disease in women with down syndrome.
[Is it personalized treatment of dementia based on the CYP2D6 gene polymorphism possible?]
Amebiasis
Identification of genes and pathways in esophageal adenocarcinoma using bioinformatics analysis.
Screening and identification of potential target genes in head and neck cancer using bioinformatics analysis.
Amyotrophic Lateral Sclerosis
Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis.
AVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for the treatment of pseudobulbar affect and neuropathic pain.
CYP1A2 rs762551 polymorphism and risk for amyotrophic lateral sclerosis.
Debrisoquine hydroxylase gene polymorphism frequencies in patients with amyotrophic lateral sclerosis.
Polymorphic sparteine metabolism and amyotrophic lateral sclerosis.
[The excessive activity of cytochrome P450 system in ALS--the metabolic ratio of sparteine]
Anaphylaxis
Different expression patterns of hepatic cytochrome P450 s during anaphylactic or lipopolysaccharide-induced inflammation.
[Effect of glycine on liver cytochrome P-450 and severity of experimental food anaphylaxis]
[The effect of gamma-L-glutamylhistamine analogues on the severity of experimental anaphylactic reaction, hormonal status and liver cytochrome P450 system]
Androgen-Insensitivity Syndrome
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Anemia
CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum.
CYP2E1 activity and children with obesity: possible confounding factors.
Effect of erythropoietin on hepatic cytochrome P450 expression and function in an adenine-fed rat model of chronic kidney disease.
Heme oxygenase induction. A possible factor in aluminum-associated anemia.
Mycophenolic acid-related anemia and leucopenia in renal transplant recipients are related to genetic polymorphisms in CYP2C8.
Revalidation of CoaguChek XS plus system for INR monitoring in Taiwanese patients: effects of clinical and genetic factors.
Sickle Cell Anemia: Variants in the CYP2D6, CAT, and SLC14A1 Genes Are Associated With Improved Hydroxyurea Response.
VDR gene polymorphisms impact on anemia at 2 weeks of anti-HCV therapy: a possible mechanism for early RBV-induced anemia.
Anemia, Aplastic
Cytochrome P4501A1 and glutathione S transferase gene polymorphisms in patients with aplastic anemia in India.
Increased formation of DNA adducts in cultured fibroblasts of patients with aplastic anemia after in vitro incubation with benzo(a)pyrene.
Study of the association between cytochromes P450 2D6 and 2E1 genotypes and the risk of drug and chemical induced idiosyncratic aplastic anaemia.
Anemia, Hemolytic
Dapsone in rheumatoid arthritis.
Pharmacogenetic testing in the Veterans Health Administration (VHA): policy recommendations from the VHA Clinical Pharmacogenetics Subcommittee.
Anemia, Sickle Cell
(281) Genetic variability of UGT2B7, CYP3A4, CYP3A5 and CYP2B6 DMETs in a sickle cell disease patient cohort.
CYP2C9 Allelic Variants and Frequencies in a Pediatric Sickle Cell Disease Cohort: Implications for NSAIDs Pharmacotherapy.
Cytochrome P450 2D6 Polymorphisms and Predicted Opioid Metabolism in African American Children With Sickle Cell Disease.
Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease.
Preemptive Genotyping of CYP2C8 and CYP2C9 Allelic Variants Involved in NSAIDs Metabolism for Sickle Cell Disease Pain Management.
Sickle Cell Anemia: Variants in the CYP2D6, CAT, and SLC14A1 Genes Are Associated With Improved Hydroxyurea Response.
The pharmacokinetics of codeine and its metabolites in Blacks with sickle cell disease.
Anencephaly
Quantitative evaluation of human placental aromatase in abnormal pregnancy--anencephalus and hydatidiform mole.
Aneurysm
The Effect of CYP1A1 and GSTP1 Isozymes on the Occurrence of Aortic Aneurysms.
Angina, Stable
[The value of cytochrome P4502C19 gene assay for anti-platelet therapy after PCI in stable angina patients with left main coronary artery lesions].
Aniridia
A Novel CYP1B1 Mutation with Congenital Glaucoma and Total Aniridia.
Congenital aniridia: etiology, manifestations and management.
Molecular characterization of Axenfeld-Rieger spectrum and other anterior segment dysgeneses in a sample of Mexican patients.
Molecular Characterization Of Newborn Glaucoma Including A Distinct Aniridic Phenotype.
Novel CYP1B1 and known PAX6 mutations in anterior segment dysgenesis (ASD).
Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia.
Anosmia
[Traumatic anosmia]
Anovulation
In Search of New Therapeutics-Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond.
Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17beta-oestradiol.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
The pharmacogenomic association of Fc? receptors and cytochrome p450 enzymes and response to treatment with rituximab or cyclophosphamide in Anti-Neutrophil Cytoplasmic Antibody-Associated vasculitis.
Antley-Bixler Syndrome Phenotype
Akhenaten and the strange physiques of Egypt's 18th dynasty.
Mouse Knockout of the Cholesterogenic Cytochrome P450 Lanosterol 14{alpha}-Demethylase (Cyp51) Resembles Antley-Bixler Syndrome.
Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome.
P450 oxidoreductase deficiency: a new disorder of steroidogenesis affecting all microsomal P450 enzymes.
P450 Oxidoreductase deficiency: Analysis of mutations and polymorphisms.
Anus Neoplasms
Drug interactions between antineoplastic and antiretroviral therapies: Implications and management for clinical practice.
Aortic Aneurysm
Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice.
The Effect of CYP1A1 and GSTP1 Isozymes on the Occurrence of Aortic Aneurysms.
Aortic Aneurysm, Abdominal
Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice.
Apnea
Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny.
Induction of cytochrome P450 1A by cow milk-based formula: a comparative study between human milk and formula.
Argininosuccinic Aciduria
Ascorbic acid deficiency reduces the level of mRNA for cytochrome P-450 on the induction by polychlorinated biphenyls.
Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs.
aromatase deficiency
A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom).
An Intron 9 CYP19 Gene Variant (IVS9+5G>A), Present in an Aromatase-Deficient Girl, Affects Normal Splicing and Is Also Present in Normal Human Steroidogenic Tissues.
Aromatase deficiency and estrogen resistance: from molecular genetics to clinic.
Aromatase deficiency caused by a novel P450arom gene mutation: impact of absent estrogen production on serum gonadotropin concentration in a boy.
Aromatase Deficiency due to a Homozygous CYP19A1 Mutation in a 46,XX Egyptian Patient with Ambiguous Genitalia.
Aromatase deficiency in a female who is compound heterozygote for two new point mutations in the P450arom gene: impact of estrogens on hypergonadotropic hypogonadism, multicystic ovaries, and bone densitometry in childhood.
Aromatase deficiency: A case series of 46, XX Chinese children and a systematic review of the literature.
Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: effects of testosterone, alendronate, and estradiol treatment.
Genetic mutations resulting in estrogen insufficiency in the male.
Human gene mutations. Gene symbol: CYP19. Disease: Aromatase deficiency.
Hypothalamic-pituitary-ovarian axis during infancy, early and late prepuberty in an aromatase-deficient girl who is a compound heterocygote for two new point mutations of the CYP19 gene.
Impact of estrogen replacement therapy in a male with congenital aromatase deficiency caused by a novel mutation in the CYP19 gene.
Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.
The cytochrome P450 aromatase lacking exon 5 is associated with a phenotype of nonclassic aromatase deficiency and is also present in normal human steroidogenic tissues.
Arrhythmias, Cardiac
Bortezomib: new indication. Second-line treatment of myeloma: limited efficacy, major risks.
Cilostazol: new drug. Intermittent claudication: too little efficacy, too many risks.
Development of Robust 17(R),18(S)-Epoxyeicosatetraenoic Acid (17,18-EEQ) Analogues as Potential Clinical Antiarrhythmic Agents.
Domperidone, cytochrome P450 3A4 isoenzyme inhibitors and ventricular arrhythmia: a nationwide case-crossover study.
Effects of H1 antihistamines on animal models of QTc prolongation.
Integrated Isogenic Human Induced Pluripotent Stem Cell-Based Liver and Heart Microphysiological Systems Predict Unsafe Drug-Drug Interaction.
Irritable Bowel Syndrome.
Optimal management of patients with non-ulcer dyspepsia: considerations for the treatment of the elderly.
QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients.
Review of Dextromethorphan 20 mg/Quinidine 10 mg (NUEDEXTA(®)) for Pseudobulbar Affect.
Role of cytochrome P450 genotype in the steps toward personalized drug therapy.
Torsades de pointes associated with methadone and voriconazole.
Urinary antispasmodic use and the risks of ventricular arrhythmia and sudden death in older patients.
[A new cause of torsades de pointes: combination of terfenadine and troleandomycin]
Arteriosclerosis
Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan.
Arthralgia
Letrozole concentration is associated with CYP2A6 variation but not with arthralgia in patients with breast cancer.
Safety and tolerability of quinupristin/dalfopristin: administration guidelines.
Arthritis
17alpha-hydroxylase/C17-20 lyase cytochrome P450 mRNA expressions and enzyme activities during the development of arthritis in collagen-induced arthritis mice.
Changes in expression of hepatic cytochrome P450 subfamily enzymes during development of adjuvant-induced arthritis in rats.
DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad.
Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver.
Murine collagen antibody induced arthritis (CAIA) and primary mouse hepatocyte culture as models to study cytochrome P450 suppression.
Profiling of hepatic metabolizing enzymes and nuclear receptors in rats with adjuvant arthritis by targeted proteomics.
The Effect of Infliximab on Hepatic Cytochrome P450 and Pharmacokinetics of Verapamil in Rats with Pre-Adjuvant Arthritis: A Drug-Disease and Drug-Drug Interaction.
Arthritis, Experimental
17alpha-hydroxylase/C17-20 lyase cytochrome P450 mRNA expressions and enzyme activities during the development of arthritis in collagen-induced arthritis mice.
Analgesic and anti-inflammatory activity of 6-chloro-alpha-methyl-carbazole-2-acetic acid (C-5720).
Drug-Disease Interaction: Effect of Inflammation and Nonsteroidal Anti-Inflammatory Drugs on Cytochrome P450 Metabolites of Arachidonic Acid.
Effect of early phase adjuvant arthritis on hepatic P450 enzymes and pharmacokinetics of verapamil: an alternative approach to the use of an animal model of inflammation for pharmacokinetic studies.
Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner.
Arthritis, Psoriatic
Cytochrome p450 1Al gene polymorphisms in patients with psoriatic arthritis.
Arthritis, Reactive
Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in reactive arthritis.
Arthritis, Rheumatoid
ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect renal function in patients with rheumatoid arthritis.
CYP-derived eicosanoids: Implications for rheumatoid arthritis.
CYP1A2 genotype and rheumatoid arthritis in Koreans.
CYP2D6 and CYP3A4 variants influence the risk and outcome of COVID-19 infection among rheumatoid arthritis patients maintained on hydroxychloroquine.
Development of a Physiologically Based Pharmacokinetic Model to Predict Disease-Mediated Therapeutic Protein-Drug Interactions: Modulation of Multiple Cytochrome P450 Enzymes by Interleukin-6.
Disease-Drug Interaction of Sarilumab and Simvastatin in Patients with Rheumatoid Arthritis.
Disease-Drug-Drug Interaction Involving Tocilizumab and Simvastatin in Patients With Rheumatoid Arthritis.
Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver.
Effects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates: A Study With the Modified Cooperstown 5+1 Cocktail.
Evaluation of disease-mediated therapeutic protein-drug interactions between an anti-interleukin-6 monoclonal antibody (sirukumab) and cytochrome P450 activities in a phase 1 study in patients with rheumatoid arthritis using a cocktail approach.
Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients.
Genetic polymorphism of CYP1A2 but not total or free teriflunomide concentrations is associated with leflunomide cessation in rheumatoid arthritis.
Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients.
Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis.
Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice.
Manganese superoxide dismutase and cytochrome P450 1A1 genes polymorphisms in rheumatoid arthritis in Taiwan.
Modeling therapeutic antibody-small molecule drug-drug interactions using a 3D perfusable human liver co-culture platform.
No significant effects of sodium aurothiomalate on haem metabolism and mixed function oxygenase activity in patients with rheumatoid arthritis.
Phenotype/genotype relationships for the cytochrome P450 enzyme CYP2D6 in rheumatoid arthritis: influence of drug therapy and disease activity.
Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis.
Relationship between genotype for the cytochrome P450 CYP2D6 and susceptibility to ankylosing spondylitis and rheumatoid arthritis.
Semiphysiologically Based Pharmacokinetic Model of Leflunomide Disposition in Rheumatoid Arthritis Patients.
Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3.
Transcriptomic profiling as biological markers of depression - A pilot study in unipolar and bipolar women.
Urinary 6 beta-hydroxycortisol excretion in rheumatoid arthritis.
Asbestosis
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Decreased Cyp2E1 mRNA expression in human leucocytes in patients with fibrotic and inflammatory lung diseases.
Ascorbic Acid Deficiency
Increased CYP1A2 content and capacity to activate Glu-P-1 and Trp-P-2 in liver microsomes of scorbutic ODS rats.
Ovarian aromatase activity in scorbutic mutant rats unable to synthesize ascorbic acid.
Vitamin C deficiency increases the binucleation of hepatocytes in SMP30 knock-out mice.
Aspergillosis
Clinical Impact of Cytochrome P450 2C19 Genotype on the Treatment of Invasive Aspergillosis under Routine Therapeutic Drug Monitoring of Voriconazole in a Korean Population.
Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4.
Voriconazole: new preparation. Invasive aspergillosis: benefits to be confirmed.
[Immunosuppression: a case of mucoviscidosis]
Asthenozoospermia
Abnormal arachidonic acid metabolic network may reduce sperm motility via P38 MAPK.
Asthma
Activation of aryl hydrocarbon receptor (AhR) in mesenchymal stem cells modulates macrophage polarization in asthma.
Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats.
Altered vulnerability to asthma at various levels of ambient Benzo[a]Pyrene by CTLA4, STAT4 and CYP2E1 polymorphisms.
Association of matrix metalloproteinase 8 genetic polymorphisms with bronchial asthma in a Japanese population.
Association of vitamin D gene polymorphisms in children with asthma - A systematic review.
Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios.
Associations Between Genetic Variants in Vitamin D Metabolism and Asthma Characteristics in Young African Americans: A Pilot Study.
Asthma and genes encoding components of the vitamin D pathway.
Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
Discovery of potential asthma targets based on the clinical efficacy of Traditional Chinese Medicine formulas.
Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation.
Fluticasone Propionate Pharmacogenetics: CYP3A4*22 Polymorphism and Pediatric Asthma Control.
Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility.
Glutathione- S-transferase micro and theta gene polymorphisms as new risk factors of atopic bronchial asthma.
Herb-drug interactions: Effect of Ginkgo biloba extract on the pharmacokinetics of theophylline in rats.
Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis.
Implications of pharmacogenomics in the current and future treatment of asthma.
Increased expression and decreased activity of cytochrome P450 1A1 in a murine model of toluene diisocyanate-induced asthma.
Pharmacogenetic Factors Affecting Asthma Treatment Response. Potential Implications for Drug Therapy.
Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma.
Steroid requirements and immune associations with vitamin D are stronger in children than adults with asthma.
The early detection of asthma based on blood gene expression.
The relationship among IL-13, GSTP1, and CYP1A1 polymorphisms and environmental tobacco smoke in a population of children with asthma in Northern Mexico.
Transporter-mediated hepatic uptake plays an important role in the pharmacokinetics and drug-drug interactions of montelukast.
[PHARMACOGENETIC MARKERS OF THE EFFECTIVENESS OF TREATMENT OF CHILDREN WITH ATOPIC BRONCHIAL ASTHMA.]
[Polymorphic genes of xenobiotic-metabolizing enzymes associated with bronchial asthma in genetically predisposed children]
[Role of xenobiotic biotransformation enzymes in susceptibility to bronchial asthma and in formation of its clinical phenotypic features]
[Significance of CYP2D6 oxidation genotype as a risk factor in development of allergic diseases]
Asthma, Aspirin-Induced
Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter.
Astrocytoma
17?-estradiol induces temozolomide resistance through NRF2-mediated redox homeostasis in glioblastoma.
Astroglial CYP1B1 up-regulation in inflammatory/oxidative toxic conditions: IL-1beta effect and protection by N-acetylcysteine.
Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target.
Cytochrome P450 1B1 mRNA in the human central nervous system.
Expression profile of cytochrome P450s and effects of polycyclic aromatic hydrocarbons and antiepileptic drugs on CYP1 expression in MOG-G-CCM cells.
Human brain cytochrome P450 1B1: immunohistochemical localization in human temporal lobe and induction by dimethylbenz(a)anthracene in astrocytoma cell line (MOG-G-CCM).
MGMT- and P450 3A-inhibitors do not sensitize glioblastoma cell cultures against nitrosoureas.
Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci.
Ataxia
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review.
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9.
Possible Genetic Determinants of Response to Phenytoin in a Group of Colombian Patients With Epilepsy.
Atherosclerosis
?-Cryptoxanthin uptake in THP-1 macrophages upregulates the CYP27A1 signaling pathway.
Acetylation phenotype and cytochrome P450IA2 phenotype are unlikely to be associated with peripheral arterial disease.
Association of CYP1A1 Gene Polymorphism with Ischemic Stroke in South Indian Population.
Biologic role(s) of the 25(R),26-hydroxycholesterol metabolic pathway.
Common polymorphisms in CYP2C9, subclinical atherosclerosis and risk of ischemic vascular disease in 52,000 individuals.
CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.
CYP2C8-derived epoxyeicosatrienoic acids decrease oxidative stress-induced endothelial apoptosis in development of atherosclerosis: Role of Nrf2 activation.
CYP2E1 Gene Polymorphisms Related to the Formation of Coronary Artery Lesions in Kawasaki Disease.
CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.
CYP2J2 Overexpression Increases EETs and Protects Against HFD-induced Atherosclerosis in ApoE-/- Mice.
Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice.
Cytochrome P450 and atherosclerosis.
Cytochrome P450 and gene activation--cholesterol elimination and regression of atherosclerosis: author reply to the commentary.
Cytochrome P450 and gene activation--from pharmacology to cholesterol elimination and regression of atherosclerosis.
Cytochrome P450--physiological key factor against cholesterol accumulation and the atherosclerotic vascular process.
Cytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and Atherosclerosis
Cytochromes CYP1A1 and CYP1B1: new pieces in the puzzle to understand the biomechanical paradigm of atherosclerosis.
Discovery of novel drug candidates for inhibition of soluble epoxide hydrolase of arachidonic acid cascade pathway implicated in atherosclerosis.
Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/ApoE Double Knockout Mice: Differential Cardiovascular Outcome.
Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.
Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice.
Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARgamma ligands.
Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux.
Gene-activators Prevent and Regress Atherosclerosis and Reduce Mortality.
Hemolymph transcriptome analysis of Chinese mitten crab (Eriocheir sinensis) with intact, left cheliped autotomy and bilateral eyestalk ablation.
Hormonal regulation of the human sterol 27-hydroxylase gene CYP27A1.
Induction of cytochrome CYPIA1 and formation of toxic metabolites of benzo[a]pyrene by rat aorta: a possible role in atherogenesis.
Marked inhibition of hepatic cytochrome P450 activity in cholesterol-induced atherosclerosis in rabbits.
Mutation in CYP27A1 identified in family with coronary artery disease.
Polymorphisms of cytochrome P450 1A1, cigarette smoking and risk of coronary artery disease.
Potential role of CYP1B1 in the development and treatment of metabolic diseases.
Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta.
Regulation of gene expression by alpha-tocopherol.
Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects.
Role of CYP2C9 and CYP2C19 polymorphisms in patients with atherosclerosis.
Role of CYP2C9 polymorphism in phenytoin-related metabolic abnormalities and subclinical atherosclerosis in young adult epileptic patients.
Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis.
The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: role of cytochrome P4501B1.
The secondary prevention of stroke according to cytochrome P450 2C19 genotype in patients with acute large-artery atherosclerosis stroke.
Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine.
[Statins: similarities and differences in the pharmacological, clinical and laboratory aspects]
Atrial Fibrillation
A new algorithm to predict warfarin dose from polymorphisms of CYP4F2 , CYP2C9 and VKORC1 and clinical variables: derivation in Han Chinese patients with non valvular atrial fibrillation.
Caffeine intake reduces incident atrial fibrillation at a population level.
Clinical application of a new warfarin-dosing regimen based on the CYP2C9 and VKORC1 genotypes in atrial fibrillation patients.
CYP2C19*17 May Increase the Risk of Death Among Patients with an Acute Coronary Syndrome and Non-Valvular Atrial Fibrillation Who Receive Clopidogrel and Rivaroxaban.
CYP2D6 Genotype-guided Metoprolol Therapy in Cardiac Surgery Patients: Rationale and Design of the Pharmacogenetic-guided Metoprolol Management for Postoperative Atrial Fibrillation in Cardiac Surgery (PREEMPTIVE) Pilot Study.
DNA sensors to assess the effect of VKORC1 and CYP2C9 gene polymorphisms on warfarin dose requirement in Chinese patients with atrial fibrillation.
Effects of different CYP2C19 genotypes on prognosis of patients complicated with atrial fibrillation taking clopidogrel after PCI.
Effects of rare CYP2C9 alleles on stable warfarin doses in Chinese Han patients with atrial fibrillation.
Evaluation of CYP2D6 oxidation of dextromethorphan and propafenone in a Chinese population with atrial fibrillation.
Factors affecting the interindividual variability of warfarin dose requirement in adult Korean patients.
Frequent Atrial Fibrillation in CYP2D6 Deficiency.
G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving ?-blockers.
Impact of ABCB1, ABCG2, and CYP3A5 polymorphisms on plasma trough concentrations of apixaban in Japanese patients with atrial fibrillation.
Interactive Association Between CYP2C9 rs2860905 Polymorphism and Atrial Fibrillation on Ischemic Stroke in Taiwan Biobank Participants.
Mineralocorticoid receptor, CYP11B2 mRNA expression, and atrial matrix remodelling in patients with atrial fibrillation.
Non-vitamin K antagonist oral anticoagulants with amiodarone, P-glycoprotein inhibitors, or polypharmacy in patients with atrial fibrillation: Systematic review and meta-analysis.
Pharmacogenetics of vitamin K antagonists and bleeding risk prediction in atrial fibrillation.
Pharmacokinetics of novel atrial-selective antiarrhythmic agent vernakalant hydrochloride injection (RSD1235): influence of CYP2D6 expression and other factors.
Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation.
Prediction of stable acenocoumarol dose by a pharmacogenetic algorithm.
Quantifying the Effect of Covariates on Concentrations and Effects of Steady-State Phenprocoumon Using a Population Pharmacokinetic/Pharmacodynamic Model.
Should we test for CYP2C9 before initiating anticoagulant therapy in patients with atrial fibrillation?
The influence of CYP2D6 polymorphism on the antiarrhythmic efficacy of propafenone in patients with paroxysmal atrial fibrillation during 3 months propafenone prophylactic treatment.
Universal versus genotype-guided use of direct oral anticoagulants in atrial fibrillation patients: a decision analysis.
Warfarin dose requirement with different genotypes of polymorphisms on CYP2C9 and VKORC1 and indications in Han-Chinese patients.
Warfarin dosing according to the genotype-guided algorithm is most beneficial in patients with atrial fibrillation: a randomized parallel group trial.
Warfarin pharmacogenetics: development of a dosing algorithm for Omani patients.
[The influence of CYP2C9 genetic polymorphism on the pharmacokinetics and pharmacodynamics of warfarin in patients with constant atrial fibrillation]
Atrial Flutter
Pharmacokinetics of novel atrial-selective antiarrhythmic agent vernakalant hydrochloride injection (RSD1235): influence of CYP2D6 expression and other factors.
Atrioventricular Block
Exacerbation of atrioventricular block associated with concomitant use of amlodipine and aprepitant in a lung cancer patient: A case report.
Autoimmune Diseases
An Open-Label Study to Assess the Effect of Itraconazole and Rifampin on Parsaclisib Pharmacokinetics When Administered Orally in Healthy Participants.
Association between Functional CYP2D6 Polymorphisms and Susceptibility to Autoimmune Diseases: A Meta-Analysis.
Decreased Activity and Genetic Polymorphisms of CYP2C19 in Behçet's Disease.
Effectiveness of Measuring Genetic Polymorphisms in Metabolizing Enzymes of Tacrolimus within One Medical Facility.
Epitope mapping of human CYP1A2 in dihydralazine-induced autoimmune hepatitis.
Imidazoacridinone antitumor agent C-1311 as a selective mechanism-based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus.
Possible role of cytochromes P450 in lupus erythematosus and related disorders.
Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice.
Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides.
Target proteins in human autoimmunity: cytochromes P450 and UDP- glucuronosyltransferases.
Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling.
The CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells.
The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity.
Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9.
Why oral opioids may not be effective in a subset of chronic pain patients.
Avitaminosis
VDR and CYP24A1 Expression Analysis in Iranian Relapsing-Remitting Multiple Sclerosis Patients.
Azoospermia
Association of CYP1A1*2A Polymorphism with Idiopathic Non-Obstructive Azoospermia in A South Indian Cohort.
Estrogen promotes Leydig cell engulfment by macrophages in male infertility.
Genetic mutations resulting in estrogen insufficiency in the male.
Babesiosis
Downregulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microti.
Repression of Hepatic Cytochrome P450 2D Expression in Mice during Babesia microti Infection.
Bacterial Infections
Aryl hydrocarbon receptor protein and Cyp1A1 gene induction by LPS and phenanthrene in Atlantic cod (Gadus morhua) head kidney cells.
Differential alterations in levels of hepatic microsomal cytochrome P450 isozymes following intracerebroventricular injection of bacterial lipopolysaccharide in rats.
TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease.
Balkan Nephropathy
Genetic polymorphisms of cytochrome P450 among patients with Balkan endemic nephropathy (BEN).
Bardet-Biedl Syndrome
Novel variants in women with premature ovarian function decline identified via whole-exome sequencing.
Barrett Esophagus
Cytochromes P450 are expressed in proliferating cells in Barrett's metaplasia.
Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma.
Bartter Syndrome
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Basal Cell Nevus Syndrome
Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome.
Behcet Syndrome
Cytochrome P450 polymorphisms in patients with Behcet's disease.
beta-Thalassemia
Modification of CYP2E1 and CYP3A4 activities in haemoglobin E-beta thalassemia patients.
Bile Duct Neoplasms
Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China.
Biliary Atresia
Immortalization of human hepatocytes from biliary atresia with CDK4R24C, cyclin D1, and TERT for cytochrome P450 induction testing.
In vitro cytochrome p450 activity decreases in children with high pediatric end-stage liver disease scores.
Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis.
Biliary Tract Neoplasms
Phase II study of S-1 combined with oxaliplatin as therapy for patients with metastatic biliary tract cancer: influence of the CYP2A6 polymorphism on pharmacokinetics and clinical activity.
Bisphosphonate-Associated Osteonecrosis of the Jaw
A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer.
Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis.
CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma.
Blepharospasm
CYP1A2 rs762551 and ADORA2A rs5760423 Polymorphisms in Patients with Blepharospasm.
Blindness
A novel methodology for enhanced and consistent heterologous expression of unmodified human cytochrome P450 1B1 (CYP1B1).
Goniodysgenesis variability and activity of CYP1B1 genotypes in primary congenital glaucoma.
Blister
Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes.
Bone Diseases
Hypercalcemia, Hypercalciuria, and Elevated Calcitriol Concentrations with Autosomal Dominant Transmission Due to CYP24A1 Mutations: Effects of Ketoconazole Therapy.
Bone Diseases, Metabolic
The CYP3A4*18 genotype in the cytochrome P450 3A4 gene, a rapid metabolizer of sex steroids, is associated with low bone mineral density.
Bone Resorption
Cytochrome P-450 inhibition blocks bone resorption in vitro and in vivo.
Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis.
Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes.
Bowen's Disease
Activation and overexpression of the aryl hydrocarbon receptor contribute to cutaneous squamous cell carcinomas: an immunohistochemical study.
Bradycardia
A metoprolol-terbinafine combination induced bradycardia.
Antidepressants, metoprolol and the risk of bradycardia.
Association of CYP2D6 single-nucleotide polymorphism with response to ophthalmic timolol in primary open-angle Glaucoma--a pilot study.
Cardiac toxicity of 5-ring polycyclic aromatic hydrocarbons is differentially dependent on the aryl hydrocarbon receptor 2 isoform during zebrafish development.
Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny.
Combining Antidepressants with ?-Blockers: Evidence of a Clinically Significant CYP2D6 Drug Interaction.
CYP2D6 polymorphism and its impact on the clinical response to metoprolol: A systematic review and meta-analysis.
Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in beta-blocker users.
Ophthalmic timolol: plasma concentration and systemic cardiopulmonary effects.
Profound metoprolol-induced bradycardia precipitated by acetaminophen-propoxyphene.
Topical timolol for treatment of epistaxis in hereditary haemorrhagic telangiectasia associated with bradycardia: a look at CYP2D6 metabolising variants.
[Pharmacokinetic risk factors of beta-blockers overdose in the elderly: Case report and pharmacology approach].
[Relationship of blood aryl hydrocarbon receptor mRNA and cytochrome P450 1A1 mRNA expression with corrected QT interval among residents exposed to arsenic via drinking water].
Brain Diseases
Constitutive Androstane Receptor: A Peripheral and a Neurovascular Stress or Environmental Sensor.
Pathophysiological implications of neurovascular P450 in brain disorders.
Possible role of CYP2B6 genetic polymorphisms in ifosfamide-induced encephalopathy: report of three cases.
Recent examples on the clinical relevance of the CYP2D6 polymorphism and endogenous functionality of CYP2D6.
The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain.
[Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced influenza-virus-associated encephalopathy]
Brain Edema
Involvement of CYP2E1 in the Course of Brain Edema Induced by Subacute Poisoning With 1,2-Dichloroethane in Mice.
[Expression of CYP2E1 in different brain regions during the formation of toxic cerebral edema induced by 1, 2-DCE in mice and its effect on cerebral edema formation].
Brain Injuries
Cytochrome P450 eicosanoids in cerebrovascular function and disease.
Distribution and expression of soluble epoxide hydrolase in human brain.
P450 Eicosanoids and Reactive Oxygen Species Interplay in Brain Injury and Neuroprotection.
Subarachnoid Hemorrhage Pattern Predicts Acute Cerebral Blood Flow Response in the Rat.
Brain Injuries, Traumatic
Differential effects of traumatic brain injury on the cytochrome p450 system: a perspective into hepatic and renal drug metabolism.
Effect of Traumatic Brain Injury, Erythropoietin, and Anakinra on Hepatic Metabolizing Enzymes and Transporters in an Experimental Rat Model.
Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system.
Impacts of Blast-Induced Traumatic Brain Injury on Expressions of Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats.
Molecular Pathomechanisms of Impaired Flow-Induced Constriction of Cerebral Arteries Following Traumatic Brain Injury: A Potential Impact on Cerebral Autoregulation.
Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury.
Brain Ischemia
Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor.
Cytochrome P450 CYP2E1 Suppression Ameliorates Cerebral Ischemia Reperfusion Injury.
Interaction of clopidogrel and statins in secondary prevention after cerebral ischemia - a randomized, double-blind, double-dummy crossover-study.
Pharmacogenomics of Cytochrome P450 of Nimodipine Metabolism After Aneurysmal Subarachnoid Hemorrhage.
Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.
Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury.
Brain Neoplasms
A population-based case-control study of the CYP2D6 and GSTT1 polymorphisms and malignant brain tumors.
An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors.
CYP2C9 polymorphisms in human tumors.
Cytochrome P450 in normal human brain and brain tumours.
Debrisoquine hydroxylase gene polymorphism in meningioma.
Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm.
Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene.
Expression and induction of cytochrome P-450 1A1 and P-450 2D subfamily in the rat glioma C6 cell line.
Expression of CYP1A1 and GSTP1 in human brain tumor tissues in Pakistan.
Expression, induction and regulation of the cytochrome P450 monooxygenase system in the rat glioma C6 cell line.
Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors.
Glutathione S-Transferases and Cytochrome P450 Enzyme Expression in Patients with Intracranial Tumors: Preliminary Report of 55 Patients.
New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol.
Novel Functional Association of Serine Palmitoyltransferase Subunit 1-A Peptide in Sphingolipid Metabolism with Cytochrome P4501A1 Transactivation and Proliferative Capacity of the Human Glioma LN18 Brain Tumor Cell Line.
P450-expression in brain tumors.
The potential effect of gender in CYP1A1 and GSTM1 genotype-specific associations with pediatric brain tumor.
The Role of Levetiracetam in Treatment of Seizures in Brain Tumor Patients.
Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system.
Transcriptional Effects of Dietary Exposure of Oil-Contaminated Calanus finmarchicus in Atlantic Herring (Clupea harengus).
Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors.
Breast Diseases
Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease.
Breast Neoplasms
1,25-Dihydroxyvitamin D3 inhibits growth of the breast cancer cell line MCF-7 and downregulates cytochrome P4501B1 through the COX-2/PGE2 pathway.
1-[(Benzofuran-2-yl)phenylmethyl]triazoles as steroidogenic inhibitors: synthesis and in vitro inhibition of human placental CYP19 aromatase.
12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells.
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA.
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.
2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates estradiol-induced aldehydic DNA lesions in human breast cancer cells through alteration of CYP1A1 and CYP1B1 expression.
2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the induction of DNA strand breaks and poly(ADP-ribose) polymerase-1 activation by 17beta-estradiol in human breast carcinoma cells through alteration of CYP1A1 and CYP1B1 expression.
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta.
27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression.
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.
4-(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides as new antimitotic prodrugs activated by cytochrome P450 1A1 in breast cancer cells.
4-Hydroxyphenylretinamide (4HPR) derivatives regulate aromatase activity and expression in breast cancer cells.
7-ethoxyresorufin O-deethylase (EROD) activity is not capable of reflecting the overall malignant potential of breast cancer tissue.
A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density.
A comprehensive examination of CYP19 variation and risk of breast cancer using two haplotype-tagging approaches.
A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort.
A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk.
A CYP1A1 restriction fragment length polymorphism is associated with breast cancer in African-American women.
A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk.
A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.
A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells.
A multigenic study on breast cancer risk associated with genetic polymorphisms of ER Alpha, COMT and CYP19 gene in BRCA1/BRCA2 negative Shanghai women with early onset breast cancer or affected relatives.
A penalized mixture model approach in genotype/phenotype association analysis for quantitative phenotypes.
A pooled analysis of CYP2D6 genotype in breast cancer prevention trials of low-dose tamoxifen.
A positive feedback pathway of estrogen biosynthesis in breast cancer cells is contained by resveratrol.
A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis.
A rare CYP19 (aromatase) variant may increase the risk of breast cancer.
A Review of Daclatasvir Drug-Drug Interactions.
A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma.
A study on the association of cytochrome-P450 1A1 polymorphism and breast cancer risk in north Indian women.
A suite of activity-based probes for human cytochrome P450 enzymes.
A tetranucleotide repeat polymorphism in CYP19 and breast cancer risk.
A tetranucleotide repeat polymorphism in the CYP19 gene and breast cancer susceptibility in a Greek population exposed and not exposed to pesticides.
A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation.
A variant in the cytochrome p450 oxidoreductase gene is associated with breast cancer risk in African Americans.
Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells.
Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.
Activity Levels of Tamoxifen Metabolites at the Estrogen Receptor and the Impact of Genetic Polymorphisms of Phase I and II Enzymes on Their Concentration Levels in Plasma.
Additional Utility of Pharmacogenomics (PGx) Panel Testing in a CYP2D6 Normal Metabolizer with a History of Breast Cancer.
Adipose tissue PCB levels and CYP1B1 and COMT genotypes in relation to breast cancer risk in postmenopausal Danish women.
Adjusting the dose of tamoxifen in patients with early breast cancer and CYP2D6 poor metabolizer phenotype.
African American-preponderant single nucleotide polymorphisms (SNPs) and risk of breast cancer.
Age-related changes in mRNA levels of hepatic transporters, cytochrome P450 and UDP-glucuronosyltransferase in female rats.
Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions.
Amino alcohol acrylonitriles as broad spectrum and tumour selective cytotoxic agents.
Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells.
An optimized protocol for mRNA quantification using nested competitive RT-PCR.
Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer.
Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies.
Analysis of the aromatase cytochrome P450 gene in human breast cancers.
Analysis of the rs10046 polymorphism of aromatase (CYP19) in premenopausal onset of human breast cancer.
Androgens influence estrogen-induced responses in human breast carcinoma cells through cytochrome P450 aromatase.
Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells.
Antiproliferative effect of the Ginkgo biloba extract is associated with the enhancement of cytochrome P450 1B1 expression in estrogen receptor-negative breast cancer cells.
Antiretroviral drug transporters and metabolic enzymes in human testicular tissue: potential contribution to HIV-1 sanctuary site.
Applications of polymorphisms and pharmacogenomics in obstetrics and gynecology.
Are health technology assessments of pharmacogenetic tests feasible? A case study of CYP2D6 testing in the treatment of breast cancer with tamoxifen.
Are pharmacogenomic biomarkers an effective tool to predict taxane toxicity and outcome in breast cancer patients? Literature review.
Aromatase (CYP19) expression in tumor-infiltrating lymphocytes and blood mononuclears.
Aromatase activity and CYP19 gene expression in breast cancers.
Aromatase and breast cancer susceptibility.
Aromatase and breast cancer: W39R, an inactive protein.
Aromatase and cyclooxygenases: enzymes in breast cancer.
Aromatase, CYP1B1 and Fatty Acid Synthase Expression in Breast Tumors of BRCA1 Mutation Carriers.
Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer.
Aryl hydrocarbon hydroxylase activity in mouse, rat, and human mammary tumors.
Aryl hydrocarbon hydroxylase in mouse mammary gland.
Aryl Hydrocarbon Receptor (AhR)-Active Pharmaceuticals Are Selective AhR Modulators in MDA-MB-468 and BT474 Breast Cancer Cells.
Aryl hydrocarbon receptor activation of an antitumor aminoflavone: basis of selective toxicity for MCF-7 breast tumor cells.
Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells.
Aryl Hydrocarbon Receptor-Dependent Metabolism Plays a Significant Role in Estrogen-Like Effects of Polycyclic Aromatic Hydrocarbons on Cell Proliferation.
Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane.
Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.
Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and ?-Catenin and Akt activation.
Assessment of the impact of CYP3A polymorphisms on the formation of ?-hydroxytamoxifen and N-desmethyltamoxifen in human liver microsomes.
Association between CYP19 polymorphisms and breast cancer risk: results from 10,592 cases and 11,720 controls.
Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment.
Association between CYP2D6 genotypes and the clinical outcomes of adjuvant tamoxifen for breast cancer: a meta-analysis.
Association between CYP2D6 polymorphisms and breast cancer outcomes.
Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.
Association between early-onset breast and laryngeal cancers.
Association between Genetic Polymorphisms of CYP2D6 and Outcomes in Breast Cancer Patients with Tamoxifen Treatment.
Association between polymorphisms in estrogen metabolism genes and breast cancer development in Chinese women: A prospective case-control study.
Association between telomere length and CYP19 TTTA repetition polymorphism in healthy and breast cancer-diagnosed women.
Association between the T27C polymorphism in the cytochrome P450 c17alpha (CYP17) gene and risk factors for breast cancer.
Association of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors.
Association of CYP19 polymorphisms with breast cancer risk: A case-control study.
Association of CYP1A1 A4889G and T6235C polymorphisms with the risk of sporadic breast cancer in Brazilian women.
Association of CYP1A1 M2 (A2455G) Polymorphism with Susceptibility to Breast Cancer in Mazandaran Province, Northern Iran: A Case-control Study.
Association of CYP1A1 polymorphisms with breast cancer in North Indian women.
Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study.
Association of CYP1B1 haplotypes and breast cancer risk in Caucasian women.
Association of CYP1B1 polymorphisms and breast cancer risk.
Association of CYP1B1 Polymorphisms with Breast Cancer: A Case-Control Study in the Han Population in Ningxia Hui Autonomous Region, P. R. China.
Association of CYP1B1 with hypersensitivity induced by Taxane therapy in breast cancer patients.
Association of CYP2D6 and CYP2C19 polymorphisms and disease-free survival of Thai post-menopausal breast cancer patients who received adjuvant tamoxifen.
Association of CYP2D6 genotype and tamoxifen metabolites with breast cancer recurrence in a low-dose trial.
Association of CYP2D6 metabolizer status with mammographic density change in response to tamoxifen treatment.
Association of CYP2D6*10 (c. 100 C>T) genotype with Z-END Concentration in Patients with Breast Cancer Receiving Tamoxifen Therapy in Indonesian Population.
Association of CYP2E1, STK15 and XRCC1 Polymorphisms with Risk of Breast Cancer in Malaysian Women.
Association of Cytochrome CYP1A1 Gene Polymorphisms and Tobacco Smoking With the Risk of Breast Cancer in Women From Iraq.
Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer.
Association of cytochrome P450 genetic polymorphisms with neoadjuvant chemotherapy efficacy in breast cancer patients.
Association of DNA-protein crosslinks and breast cancer.
Association of genetic polymorphisms in CYP19 and CYP1A1 with the oestrogen receptor-positive breast cancer risk.
Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women.
Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients.
Association of polymorphic G1934A variant (allele *4) of CYP2D6 gene with increased risk of breast cancer development in Ukrainian women.
Association of single nucleotide polymorphisms in CYP1B1 and COMT genes with breast cancer susceptibility in Indian women.
Association of single nucleotide polymorphisms of cytochrome P450 enzymes with experience of vasomotor, vaginal and musculoskeletal symptoms among breast cancer patients: a systematic review.
Association of the genetic polymorphism of the CYP19 intron 4[TTTA]n repeat with familial prostate cancer risk in a Japanese population.
Associations between aromatase CYP19 rs10046 polymorphism and breast cancer risk: from a case-control to a meta-analysis of 20,098 subjects.
Associations between breast cancer susceptibility gene polymorphisms and clinicopathological features.
Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors.
Astemizole Synergizes Calcitriol Antiproliferative Activity by Inhibiting CYP24A1 and Upregulating VDR: A Novel Approach for Breast Cancer Therapy.
Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism.
Benzo[a]pyrene-resistant MCF-7 human breast cancer cells. A unique aryl hydrocarbon-nonresponsive clone.
Berberine Activates Aryl Hydrocarbon Receptor but Suppresses CYP1A1 Induction through miR-21-3p Stimulation in MCF-7 Breast Cancer Cells.
Bias analysis to guide new data collection.
Boron-Based 4-Hydroxytamoxifen Bioisosteres for Treatment of de Novo Tamoxifen Resistant Breast Cancer.
BRCA1 Breast Cancer Risk Is Modified by CYP19 Polymorphisms in Ashkenazi Jews.
Breast cancer and CYPIA1, GSTM1, and GSTT1 polymorphisms: evidence of a lack of association in Caucasians and African Americans.
Breast cancer and flavonoids - A role in prevention.
Breast Cancer Association with CYP1A2 Activity and Gene Polymorphisms--a Preliminary Case-control Study in Tunisia.
Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen.
Breast cancer risk associated with CYP1A1 genetic polymorphisms in Japanese women.
Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility.
Breast cancer risk associated with polymorphism in CYP19 in Japanese women.
Breast cancer risk, fungicide exposure and CYP1A1*2A gene-environment interactions in a province-wide case control study in Prince Edward Island, Canada.
Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes.
Breast cancer, panic disorder, and CYP2D6: a case study.
Breast cancer: Occluded role of mitochondria N-acetylserotonin/melatonin ratio in co-ordinating pathophysiology.
Breast density and polymorphisms in genes coding for CYP1A2 and COMT: the Multiethnic Cohort.
Calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor.
Camouflaged, activatable and therapeutic tandem bionanoreactors for breast cancer theranosis.
Can tamoxifen therapy be optimized for patients with breast cancer on the basis of CYP2D6 activity assessments?
Carbon Monoxide Inhibits Cytochrome P450 Enzymes CYP3A4/2C8 in Human Breast Cancer Cells, Increasing Sensitivity to Paclitaxel.
Cellular apoptosis susceptibility protein (CAS) suppresses the proliferation of breast cancer cells by upregulated cyp24a1.
Cellular Metabolism in High-Throughput In Vitro Reporter Gene Assays and Implications for the Quantitative In Vitro-In Vivo Extrapolation.
Changes in expression of drug-metabolizing enzymes by single-walled carbon nanotubes in human respiratory tract cells.
Characterization and Biological Potency of Mono- to Tetra-Halogenated Carbazoles.
Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution LC-MS, and quantitative HPLC analysis.
Chemosensitivity determinants of irinotecan hydrochloride in hepatocellular carcinoma cell lines.
Chrysoeriol Prevents TNF?-Induced CYP19 Gene Expression via EGR-1 Downregulation in MCF7 Breast Cancer Cells.
Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study.
Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women.
Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-?, and ER?: results from the EPIC-Heidelberg cohort.
Clinical CYP2D6 Genotyping to Personalize Adjuvant Tamoxifen Treatment in ER-Positive Breast Cancer Patients: Current Status of a Controversy.
Clinical effects of A4889G and T6235C polymorphisms in cytochrome P-450 CYP1A1 for breast cancer patients treated with tamoxifen: implications for tumor aggressiveness and patient survival.
Clinical epidemiology and pharmacology of CYP2D6 inhibition related to breast cancer outcomes.
Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer.
Clinical implications of CYP2D6 genotyping in tamoxifen treatment for breast cancer.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.
Clinical Relevance of CYP2D6 Genetics for Tamoxifen Response in Breast Cancer.
Clinical significance of CYP2D6 polymorphisms and tamoxifen in women with breast cancer.
Clinical Trial: CYP2D6 Related Dose Escalation of Tamoxifen in Breast Cancer Patients With Iranian Ethnic Background Resulted in Increased Concentrations of Tamoxifen and Its Metabolites.
Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue.
Co-administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects.
Co-planar 3,3',4,4',5-pentachlorinated biphenyl and non-co-planar 2,2',4,6,6'-pentachlorinated biphenyl differentially induce recruitment of oestrogen receptor alpha to aryl hydrocarbon receptor target genes.
Cobicistat Boosts the Intestinal Absorption of Transport Substrates, Including HIV Protease Inhibitors and GS-7340, In Vitro.
Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status.
Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine.
Combined effect of CYP1B1 codon 432 polymorphism and N-acetyltransferase 2 slow acetylator phenotypes in relation to breast cancer in the Turkish population.
Combined effect of CYP1B1, COMT, GSTP1, and MnSOD genotypes and risk of postmenopausal breast cancer.
Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols.
Common genetic variants in the vitamin D pathway including genome-wide associated variants are not associated with breast cancer risk among Chinese women.
Comparative molecular field analysis of non-steroidal aromatase inhibitors: an extended model for two different structural classes.
Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines.
Comparative study of polymorphism frequencies of the CYP2D6, CYP3A5, CYP2C8 and IL-10 genes in Mexican and Spanish women with breast cancer.
Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients.
Comprehensive and Automated Linear Interaction Energy Based Binding-Affinity Prediction for Multifarious Cytochrome P450 Aromatase Inhibitors.
Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy.
Computational Treatment Simulations to Assess the Need for Personalized Tamoxifen Dosing in Breast Cancer Patients of Different Biogeographical Groups.
Concomitant use of tamoxifen and endoxifen in postmenopausal early breast cancer: prediction of plasma levels by physiologically-based pharmacokinetic modeling.
Concordance Between CYP2D6 Genotypes Obtained From Tumor-Derived and Germline DNA.
Concurrent use of tamoxifen with CYP2D6 inhibitors and the risk of breast cancer recurrence.
Constitutional genetic variation at the human aromatase gene (Cyp19) and breast cancer risk.
Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue.
Contribution of ABCB1 and CYP2D6 genotypes to the outcome of tamoxifen adjuvant treatment in premenopausal women with breast cancer.
Coprescription of Tamoxifen and Medications That Inhibit CYP2D6: Recommendations Based on the Proposals by the Grading of Recommendations Assessment, Development, and Evaluation Working Group.
Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene.
Correlation of aromatase and cyclooxygenase gene expression in human breast cancer specimens.
Cost-effectiveness Analysis of CYP2D6*10 Pharmacogenetic Testing to Guide the Adjuvant Endocrine Therapy for Postmenopausal Women with Estrogen Receptor Positive Early Breast Cancer in China.
Covariate adjustment in family-based association studies.
Cross-Talk Between One-Carbon Metabolism and Xenobiotic Metabolism: Implications on Oxidative DNA Damage and Susceptibility to Breast Cancer.
Crosstalk between the peroxisome proliferator-activated receptor ? (PPAR?) and the vitamin D receptor (VDR) in human breast cancer cells: PPAR? binds to VDR and inhibits 1?,25-dihydroxyvitamin D(3) mediated transactivation.
Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.
Current researches on breast cancer epidemiology in Korea.
Cyclooxygenase-2 directly regulates gene expression of P450 Cyp19 aromatase promoter regions pII, pI.3 and pI.7 and estradiol production in human breast tumor cells.
Cyclophosphamide bioactivation pharmacogenetics in breast cancer patients.
CYP17 (T-34C) and CYP19 (Trp39Arg) polymorphisms and their cooperative effects on breast cancer susceptibility.
CYP17 (T34C), CYP19 (Trp39Arg), and FGFR2 (C906T) polymorphisms and the risk of breast cancer in south Indian women.
CYP19 (TTTA)n polymorphism and breast cancer risk in Brazilian women.
CYP19 gene polymorphisms and the susceptibility to breast cancer in Xinjiang Uigur women.
CYP19 genetic polymorphism haplotype AASA is associated with a poor prognosis in premenopausal women with lymph node-negative, hormone receptor-positive breast cancer.
CYP19A1 rs10046 pharmacogenetics in postmenopausal breast cancer patients treated with aromatase inhibitors: One-year follow-up.
CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population.
CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case-control study.
CYP1A1 gene polymorphisms: lack of association with breast cancer susceptibility in the southern region (Madurai) of India.
CYP1A1 genetic polymorphism is a promising predictor to improve chemotherapy effects in patients with metastatic breast cancer treated with docetaxel plus thiotepa vs. docetaxel plus capecitabine.
CYP1A1 is overexpressed upon incubation of breast cancer cells with a polyphenolic cocoa extract.
CYP1A1 M2 (A2455G) Polymorphism with Susceptibility to Breast Cancer.
CYP1A1 regulates breast cancer proliferation and survival.
CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women.
CYP1A1, GSTM1, and GSTT1 polymorphisms and breast cancer risk in Brazilian women.
CYP1A2 - a novel genetic marker for early aromatase inhibitor response in the treatment of breast cancer patients.
CYP1B1 and CYP19 gene polymorphisms and breast cancer incidence: no association in the ARIC study.
CYP1B1 and predisposition to breast cancer in Poland.
CYP1B1 expression is induced by docetaxel: effect on cell viability and drug resistance.
CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma.
CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKC? activation and phosphorylation of XIAP.
CYP24A1 polymorphisms and breast cancer risk.
CYP24A1-induced vitamin D insufficiency promotes breast cancer growth.
CYP27A1 expression is associated with risk of late lethal estrogen receptor-positive breast cancer in postmenopausal patients.
CYP2B6*6 is associated with increased breast cancer risk.
CYP2C and IL-6 expression in breast cancer.
CYP2C19*2 and CYP2C19*17 variants and effect of tamoxifen on breast cancer recurrence: Analysis of the International Tamoxifen Pharmacogenomics Consortium dataset.
CYP2C8 and CYP2C9 polymorphisms in relation to tumour characteristics and early breast cancer related events among 652 breast cancer patients.
CYP2C9 polymorphisms in human tumors.
CYP2D6 and adjuvant tamoxifen: possible differences of outcome in pre- and post-menopausal patients.
CYP2D6 and Endoxifen in Tamoxifen Therapy: A Tribute to David A. Flockhart.
CYP2D6 and tamoxifen: DNA matters in breast cancer.
CYP2D6 and UGT2B7 Genotype and Risk of Recurrence in Tamoxifen-Treated Breast Cancer Patients.
CYP2D6 as a treatment decision aid for ER-positive non-metastatic breast cancer patients: a systematic review with accompanying clinical practice guidelines.
CYP2D6 gene polymorphisms in Brazilian patients with breast cancer treated with adjuvant tamoxifen and its association with disease recurrence.
CYP2D6 gene variants and their association with breast cancer susceptibility.
CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen.
CYP2D6 Genetic Polymorphisms and Phenotypes in Different Ethnicities of Malaysian Breast Cancer Patients.
CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-analysis of Heterogeneous Study Populations.
CYP2D6 Genotype and Risk of Recurrence in Tamoxifen Treated Breast Cancer Patients.
CYP2D6 Genotype and Tamoxifen Response for Breast Cancer: A Systematic Review and Meta-Analysis.
CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women with Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial.
CYP2D6 genotype in relation to hot flashes as tamoxifen side effect in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial.
CYP2D6 genotype in relation to tamoxifen efficacy in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial.
CYP2D6 genotype is not associated with survival in breast cancer patients treated with tamoxifen: results from a population-based study.
CYP2D6 Genotype Predicts Plasma Concentrations of Tamoxifen Metabolites in Ethiopian Breast Cancer Patients.
CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer.
CYP2D6 genotype should not be used for deciding about tamoxifen therapy in postmenopausal breast cancer.
CYP2D6 genotype should not be used to determine endocrine therapy in postmenopausal breast cancer patients.
CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.
CYP2D6 genotype- and endoxifen-guided tamoxifen dose escalation increases endoxifen serum concentrations without increasing side effects.
CYP2D6 Genotype-Guided Tamoxifen Dosing in Hormone Receptor-Positive Metastatic Breast Cancer (TARGET-1): A Randomized, Open-Label, Phase II Study.
CYP2D6 genotypes in Spanish women with breast cancer.
CYP2D6 genotypes, endoxifen levels, and disease recurrence in 224 Filipino and Vietnamese women receiving adjuvant tamoxifen for operable breast cancer.
CYP2D6 genotyping and tamoxifen in the treatment of postmenopausal breast cancer.
CYP2D6 Genotyping and the Use of Tamoxifen in Breast Cancer.
CYP2D6 genotyping and use of antidepressants in breast cancer patients: test development for clinical application.
CYP2D6 genotyping in breast cancer patients by liquid chromatography-electrospray ionization mass spectrometry.
CYP2D6 Inhibition and Breast Cancer Recurrence in a Population-Based Study in Denmark.
CYP2D6 phenotype indicative for optimized antiestrogen efficacy associates with outcome in early breast cancer patients.
CYP2D6 phenotype prediction from genotype: which system is the best?
CYP2D6 phenotype, tamoxifen, and risk of contralateral breast cancer in the WECARE Study.
CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance.
CYP2D6 polymorphisms as predictors of outcome in breast cancer patients treated with tamoxifen: expanded polymorphism coverage improves risk stratification.
CYP2D6 polymorphisms influence tamoxifen treatment outcomes in breast cancer patients: a meta-analysis.
CYP2D6 polymorphisms influence the efficacy of adjuvant tamoxifen in Thai breast cancer patients.
CYP2D6 testing for breast cancer patients: is there more to the story?
CYP2D6 testing in breast cancer: ready for prime time?
CYP2D6 testing to predict response to tamoxifen in women with breast cancer. Pharmacogenomic.
CYP2D6*3 (A2549del), *4 (G1846A), *10 (C100T) and *17 (C1023T) genetic polymorphisms in Iranian breast cancer patients treated with adjuvant tamoxifen.
CYP2D6*4 allele and breast cancer risk: is there any association?
CYP2D6-inhibiting medication use and inherited CYP2D6 variation in relation to adverse breast cancer outcomes after tamoxifen therapy.
CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648) sensitivity in breast and colorectal cancer cells.
CYP3A4, CYP2C9 and CYP2B6 expression and ifosfamide turnover in breast cancer tissue microsomes.
CYP3A5*1 is an inhibitory factor for lung cancer in Taiwanese.
CYP4Z1 - A Human Cytochrome P450 Enzyme that Might Hold the Key to Curing Breast Cancer.
Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review.
Cytochrome P-450 1B1 Leu432Val Polymorphism Does Not Show Association With Breast Cancer in Northern Iranian Women With a History of Infertility.
Cytochrome P-450 2D6 (CYP2D6) Genotype and Breast Cancer Recurrence in Tamoxifen-Treated Patients: Evaluating the Importance of Loss of Heterozygosity.
Cytochrome P1B1 (CYP1B1) polymorphisms and cancer risk: a meta-analysis of 52 studies.
Cytochrome P450 1 enzyme inhibition and anticancer potential of chromene amides from Amyris plumieri.
Cytochrome P450 1A1 (CYP1A1) Gene Polymorphisms and Susceptibility to Breast Cancer: a Meta-Analysis in the Chinese Population.
Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women.
Cytochrome P450 1A1 (CYP1A1) T3801C and A2455G polymorphisms in breast cancer risk: a meta-analysis.
Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study.
Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study.
Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity.
Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and breast cancer risk in Chinese women: results from the shanghai breast cancer study and a meta-analysis.
Cytochrome P450 1B1 gene polymorphisms and postmenopausal breast cancer risk.
Cytochrome P450 1B1 promotes cancer cell survival via specificity protein 1 (Sp1)-mediated suppression of death receptor 4.
Cytochrome P450 1B1 Val432Leu polymorphism and breast cancer risk in Nigerian women: a case control study.
Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast cancer patients.
Cytochrome P450 2D6 and outcomes of adjuvant tamoxifen therapy: results of a meta-analysis.
Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells.
Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients.
Cytochrome p450 and glutathione transferase expression in human breast cancer.
Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells.
Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population.
Cytochrome P450 Genetic Variation Associated with Tamoxifen Biotransformation in American Indian and Alaska Native People.
Cytochrome p450 inhibitory properties of common efflux transporter inhibitors.
Cytochrome P450 Polymorphisms and their Relationship with Premature Ovarian Failure in Premenopausal Women with Breast Cancer Receiving Doxorubicin and Cyclophosphamide.
Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorphisms and postmenopausal breast cancer risk.
Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Nigerian women.
Cytochrome P4501A1 polymorphism as a susceptibility factor for breast cancer in postmenopausal Chinese women in Taiwan.
Cytochrome P450: Implications for human breast cancer.
Cytotoxicity and gene expression profiles of novel synthesized steroid derivatives as chemotherapeutic anti-breast cancer agents.
David Kupfer: a career retrospective.
DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study.
Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes.
Defining molecular sensors to assess long-term effects of pesticides on carcinogenesis.
Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1.
Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17?-hydroxylase-C17,20-lyase (Cyp17).
Detection of Cytochrome P450 Polymorphisms in Breast Cancer Patients May Impact on Tamoxifen Therapy
Determination of CYP2D6 *3, *4, and *10 frequency in women with breast cancer in São Luís, Brazil, and its association with prognostic factors and disease-free survival.
Development of an estrogen-dependent breast cancer co-culture model as a tool for studying endocrine disruptors.
Development, validation and clinical application of a HPLC-FL method for CYP2D6 phenotyping in South Brazilian breast cancer patients.
Development, Verification, and Prediction of Osimertinib Drug-Drug Interactions Using PBPK Modeling Approach to Inform Drug Label.
Dextromethorphan as a phenotyping test to predict endoxifen exposure in patients on tamoxifen treatment.
Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase.
Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially.
Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.
Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells.
Differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans-acting factors.
Differences in the action of lower and higher chlorinated polychlorinated naphthalene (PCN) congeners on estrogen dependent breast cancer cell line viability and apoptosis, and its correlation with Ahr and CYP1A1 expression.
Different response of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-sensitive genes in human breast cancer MCF-7 and MDA-MB 231 cells.
Differential action of chlorinated polycyclic aromatic hydrocarbons on aryl hydrocarbon receptor-mediated signaling in breast cancer cells.
Differential Association of Cytochrome P450 3A4 Genotypes With Onsets of Breast Tumors in African American Versus Caucasian Patients.
Differential effect of over-expressing UGT1A1 and CYP1A1 on xenobiotic assault in MCF-7 cells.
Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.
Differential expression of CYP1A1 and CYP1B1 in human breast cancer.
Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells.
Differential ligand-dependent activation and a role for Y322 in aryl hydrocarbon receptor-mediated regulation of gene expression.
Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7.
Discovery of a novel potent cytochrome P450 CYP4Z1 inhibitor.
Discovery of the Anti-Tumor Mechanism of Calycosin Against Colorectal Cancer by Using System Pharmacology Approach.
Distinct prevalence of the CYP19 Delta3(TTTA)(7) allele in premenopausal versus postmenopausal breast cancer patients, but not in control individuals.
Distribution of aromatase P450 transcripts and adipose fibroblasts in the human breast.
DNA damage induced by NADPH cytochrome P450 reductase-activated idarubicin in sensitive and multidrug resistant MCF7 breast cancer cells.
DNA microarray-based analysis of single nucleotide polymorphisms may be useful for assessing the risks and benefits of hormone therapy.
Do single nucleotide polymorphisms in xenobiotic metabolizing genes determine breast cancer susceptibility and treatment outcomes?
Does purified Swedish pollen extract, a nonhormonal treatment for vasomotor symptoms, inhibit the CYP2D6 enzyme system?
Does race modify the association between CYP1B1 Val432Leu polymorphism and breast cancer risk? A critical appraisal of a recent meta-analysis.
Don't think twice it's all right: tamoxifen and CYP2D6 genotyping in the treatment of breast cancer patients.
Dose escalation of tamoxifen in patients with low endoxifen level: evidence for therapeutic drug monitoring - The TADE Study.
Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients.
Down-Regulation of CYP1A1 Expression in Breast Cancer.
Downregulation of BCRP and anti-apoptotic proteins by proadifen (SKF-525A) is responsible for the enhanced mitoxantrone accumulation and toxicity in mitoxantrone-resistant human promyelocytic leukemia cells.
Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion.
Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.
Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells.
Drug metabolising enzyme polymorphisms and chemotherapy-related ovarian failure in young breast cancer survivors.
Drug-Drug Interaction Study of Apixaban with Cyclosporine and Tacrolimus in Healthy Volunteers.
Drug-metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohort.
Drug-related genetic polymorphisms affecting severe chemotherapy-induced neutropenia in breast cancer patients: A hospital-based observational study.
Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo.
Effect of a negative regulatory element (NRE) on the human CYP1A1 gene expression in breast carcinoma MCF-7 and hepatoma HepG2 cells.
Effect of biochanin A on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells.
Effect of concomitant CYP2D6 inhibitor use and tamoxifen adherence on breast cancer recurrence in early-stage breast cancer.
Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells.
Effect of CYP19 rs6493497 and rs7176005 haplotype status on in vivo aromatase transcription, plasma and tissue estrogen levels in postmenopausal women.
Effect of CYP2C19 and CYP2D6 genotype on tamoxifen treatment outcome indicates endogenous and exogenous interplay.
Effect of CYP2D6 polymorphisms on breast cancer recurrence.
Effect of dioxin and 17?-estradiol on the expression of cytochrome P450 1A1 gene via an estrogen receptor dependent pathway in cellular and xenografted models.
Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer.
Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.
Effect of imatinib mesilate on the disposition kinetics of ciclosporin in rats.
Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells.
Effect of Upadacitinib on the Pharmacokinetics of Rosuvastatin or Atorvastatin in Healthy Subjects.
Effects of Chrysin and Its Major Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide on Cytochrome P450 Enzymes and on OATP, P-gp, BCRP, and MRP2 Transporters.
Effects of conditioned medium from different cultured cell types on aromatase expression in adipose stromal cells.
Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines.
Effects of CYP2B6 genetic polymorphisms in patients receiving cyclophosphamide combination chemotherapy for breast cancer.
Effects of CYP2D6 and CYP3A5 polymorphisms on tamoxifen and its metabolites in Thai breast cancer patients.
Effects of CYP2D6 and UGT2B7 polymorphisms on pharmacokinetics of tamoxifen in Thai breast cancer patients.
Effects of CYP2D6*10 polymorphism on tamoxifen pharmacokinetics in patients with breast cancer in Asia: a meta-analysis.
Effects of morin on the pharmacokinetics of etoposide in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in female Sprague-Dawley rats.
Effects of Neonicotinoid Pesticides on Promoter-Specific Aromatase (CYP19) Expression in Hs578t Breast Cancer Cells and the Role of the VEGF Pathway.
Effects of zearalenone on mRNA expression and activity of cytochrome P450 1A1 and 1B1 in MCF-7 cells.
Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer.
Elevated levels of the Steroidogenic Factor-1 are associated with over-expression of CYP19 in an Estrogen producing testicular Leydig cell tumour.
Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778?875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha.
Endoxifen levels and its association with CYP2D6 genotype and phenotype: evaluation of a southern Brazilian population under tamoxifen pharmacotherapy.
Endoxifen's molecular mechanisms of action are concentration dependent and different than that of other anti-estrogens.
Endoxifen, the active metabolite of tamoxifen, is a substrate of the efflux transporter P-glycoprotein (multidrug resistance 1).
Environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer: a systematic review of the epidemiological evidence.
Environmental Polychlorinated Biphenyl Exposure and Breast Cancer Risk: A Meta-Analysis of Observational Studies.
EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange.
ERCC1 and CYP1B1 polymorphisms as predictors of response to neoadjuvant chemotherapy in estrogen positive breast tumors.
Erratum to: Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and ?-Catenin and Akt activation.
Erratum to: Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis.
Erratum to: The use of the (13)C-dextromethorphan breath test for phenotyping CYP2D6 in breast cancer patients using tamoxifen: association with CYP2D6 genotype and serum endoxifen levels.
Estimation of tamoxifen metabolite concentrations in the blood of breast cancer patients through CYP2D6 genotype activity score.
Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene.
Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study.
Estrogen receptor genotype is associated with risk of venous thromboembolism during tamoxifen therapy.
Estrogen receptor reduces CYP1A1 induction in cultured human endometrial cells.
Estrogen receptor subtype- and promoter-specific modulation of aryl hydrocarbon receptor-dependent transcription.
Estrogen receptor-dependent regulation of CYP2B6 in human breast cancer cells.
Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women.
Estrogen-related genes and their contribution to racial differences in breast cancer risk.
Evaluation of a real-time polymerase chain reaction method for the quantification of CYP1B1 gene expression in MCF-7 human breast carcinoma cells.
Evaluation of association studies and a systematic review and meta-analysis of CYP1A1 T3801C and A2455G polymorphisms in breast cancer risk.
Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk.
Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and P2 clinical trials.
Evaluation of CYP2D6 enzyme activity using a 13C-dextromethorphan breath test in women receiving adjuvant tamoxifen.
Evaluation of drug-drug interaction of lusutrombopag, a thrombopoietin receptor agonist, via metabolic enzymes and transporters.
Evaluation of endometrial thickness and bone mineral density based on CYP2D6 polymorphisms in Turkish breast cancer patients receiving tamoxifen treatment.
Evaluation of Tissue Stem Cell-Derived Human Intestinal Organoids, a Physiologically Relevant Model to Evaluate Cytochrome P450 Induction in Gut.
Exemestane potency is unchanged by common nonsynonymous polymorphisms in CYP19A1: results of a novel anti-aromatase activity assay examining exemestane and its derivatives.
Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in
Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status.
Expression of CYP1A1, CYP1B1 and MnSOD in a panel of human cancer cell lines.
Expression of CYP3A4 in human breast tumour and non-tumour tissues.
Expression of cytochrome P450 1B1 and catechol-O-methyltransferase in breast tissue and their associations with breast cancer risk.
Expression of cytochrome P450 CYP1B1 in breast cancer.
Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression.
Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma.
Expression of VDR and CYP24A1 mRNA in human tumors.
Expression of xenobiotic and steroid hormone metabolizing enzymes in human breast carcinomas.
First-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer.
Food constituent- and herb-drug interactions in oncology: Influence of quantitative modelling on Drug labelling.
Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis.
Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors.
Functional polymorphisms in xenobiotic metabolizing enzymes and their impact on the therapy of breast cancer.
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Further characterization of a ¹³C-dextromethorphan breath test for CYP2D6 phenotyping in breast cancer patients on tamoxifen therapy.
Gene expression and pathologic response to neoadjuvant chemotherapy in breast cancer.
Gene expression profiles of CYP24A1 and CYP27B1 in malignant and normal breast tissues.
Genetic and environmental determinants on tissue response to in vitro carcinogen exposure and risk of breast cancer.
Genetic matters of CYP2D6 in breast cancer: copy number variations and nucleotide polymorphisms.
Genetic polymorphism of cytochrome P450-1B1 and risk of breast cancer.
Genetic polymorphism of estrogen metabolizing enzymes in siberian women with breast cancer.
Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility.
Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer.
Genetic polymorphisms in estrogen metabolism and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians.
Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival.
Genetic polymorphisms in oestrogen metabolic pathway and breast cancer: a positive association with combined CYP/GST genotypes.
Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk.
Genetic polymorphisms in the three malaysian races effect granisetron clinical antiemetic actions in breast cancer patients receiving chemotherapy.
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study.
Genetic polymorphisms of CYP2D6 10 and CYP2C19 2, 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen.
Genetic polymorphisms of CYP2D6 increase the risk for recurrence of breast cancer in patients receiving tamoxifen as an adjuvant therapy.
Genetic polymorphisms of CYP2E1, GST, and NAT2 enzymes are not associated with risk of breast cancer in a sample of Lebanese women.
Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women.
Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer.
Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women.
Genetic polymorphisms of phase I metabolizing enzyme genes, their interaction with lifetime grilled and smoked meat intake, and breast cancer incidence.
Genetic testing and pharmacogenomics: issues for determining the impact to healthcare delivery and costs.
Genetic variants in hormone-related genes and risk of breast cancer.
Genetic variants of CYP19 (aromatase) and breast cancer risk.
Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer.
Genetic variants of the drug-metabolizing enzyme CYP2D6 in Puerto Rican psychiatry patients: a preliminary report and potential implications for breast cancer patients.
Genetic variation in estrogen and progesterone pathway genes and breast cancer risk: an exploration of tumor subtype-specific effects.
Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women.
Genetics of CYP1A1: coamplification of specific alleles by polymerase chain reaction and association with breast cancer.
Genistein Induces Cytochrome P450 1B1 Gene Expression and Cell Proliferation in Human Breast Cancer MCF-7 Cells.
Genomics and pharmacogenomics of breast cancer: current knowledge and trends.
Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients.
Genotype-guided adjuvant endocrine therapy: new tricks from an old drug?
Genotype-guided tamoxifen therapy: time to pause for reflection?
Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients.
Glaucarubulone glucoside from Castela macrophylla suppresses MCF-7 breast cancer cell growth and attenuates benzo[a]pyrene-mediated CYP1A gene induction.
Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme.
GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.
High Coffee Intake, but Not Caffeine, is Associated with Reduced Estrogen Receptor Negative and Postmenopausal Breast Cancer Risk with No Effect Modification by CYP1A2 Genotype.
History of Aromatase: Saga of an Important Biologic Mediator and Therapeutic Target.
Hormonal status affects plasma exposure of tamoxifen and its main metabolites in tamoxifen-treated breast cancer patients.
Hormone-related pathways and risk of breast cancer subtypes in African American women.
How valid is single nucleotide polymorphism (SNP) diagnosis for the individual risk assessment of breast cancer?
Human aromatase: gene resequencing and functional genomics.
Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells.
Hyaluronic acid-modified cationic nanoparticles overcome enzyme CYP1B1-mediated breast cancer multidrug resistance.
Identification of 3'-methoxy-4'-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells.
Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.
Identification of cytochrome P450 1A1 in human brain.
Identification of positive and negative regulatory elements of the human cytochrome P4501A2 (CYP1A2) gene.
Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues.
Immunohistochemical evaluation of cytochrome P450 (CYP) and p53 in breast cancer.
Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1.
Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer.
Impact of ABCB1 and CYP2D6 polymorphisms on tamoxifen treatment outcomes and adverse events in breast cancer patients.
Impact of CYP19A1 and ESR1 variants on early-onset side effects during combined endocrine therapy in the TEXT trial.
Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study.
Impact of CYP2D*6 in the adjuvant treatment of breast cancer patients with tamoxifen.
Impact of CYP2D6 polymorphisms in tamoxifen adjuvant breast cancer treatment.
Impact of CYP2D6 polymorphisms on endoxifen concentrations and breast cancer outcomes.
Impact of CYP2D6 polymorphisms on tamoxifen responses of women with breast cancer: a microarray-based study in Thailand.
Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy.
Impact of CYP2D6*4 genotype on progression free survival in tamoxifen breast cancer treatment.
Impact of CYP2D6, CYP3A5, CYP2C9 and CYP2C19 polymorphisms on tamoxifen pharmacokinetics in Asian breast cancer patients.
Impact of gene polymorphisms in drug-metabolizing enzymes and transporters on trough concentrations of rivaroxaban in patients with atrial fibrillation.
Impact of the CYP2D6 phenotype on the outcome of breast cancer patients treated with tamoxifen.
Impacts of Cytochrome P450 2D6 (CYP2D6) Genetic Polymorphism in Tamoxifen Therapy for Breast Cancer.
Impaired tamoxifen metabolism reduces survival in familial breast cancer patients.
Impairment of endoxifen formation in tamoxifen-treated premenopausal breast cancer patients carrying reduced-function CYP2D6 alleles.
Implication of CYP24A1 Splicing in Breast Cancer.
Implication of Xenobiotic Metabolizing Enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) polymorphisms in breast carcinoma.
Importance of asparagine-381 and arginine-487 for substrate recognition in CYP4Z1.
Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen.
In situ estrogen production and its regulation in human breast carcinoma: from endocrinology to intracrinology.
Incidence of inactive allele CYP2D6*4 among Greek women suffering from hormone-sensitive breast cancer.
Incorporating cytochrome P450 3A4 genotype expression and FT-IR/Raman spectroscopy data as means of identification of breast tumors.
Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.
Increased expression of cytochrome p450 1A1 and 1B1 genes in anti-estrogen-resistant human breast cancer cell lines.
Increasing tamoxifen dose in breast cancer patients based on CYP2D6 genotypes and endoxifen levels: effect on active metabolite isomers and the antiestrogenic activity score.
Individualization of tamoxifen therapy: Much more than just CYP2D6 genotyping.
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells.
Indolo[3,2-b]carbazole: a dietary-derived factor that exhibits both antiestrogenic and estrogenic activity.
Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites.
Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite.
Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxylated metabolites on cellular apoptosis.
Induction of cytochrome P450 1B1 in MDA-MB-231 human breast cancer cells by non-ortho-substituted polychlorinated biphenyls.
Induction of cytochrome P450 2B1 in rat liver by the aromatase inhibitor aminoglutethimide.
Induction of estradiol metabolism by dietary indole-3-carbinol in humans.
Induction of Human Intestinal and Hepatic Organic Anion Transporting Polypeptides: Where Is the Evidence for Its Relevance in Drug-Drug Interactions?
Inflammatory conditions induce IRES-dependent translation of cyp24a1.
Influence of CYP2D6 and CYP3A4 Phenotypes, Drug Interactions, and Vitamin D Status on Tamoxifen Biotransformation.
Influence of CYP2D6 polymorphisms on serum levels of tamoxifen metabolites in Spanish women with breast cancer.
Influence of CYP2D6-genotype on tamoxifen efficacy in advanced breast cancer.
Influence of Estrogenic Metabolic Pathway Genes Polymorphisms on Postmenopausal Breast Cancer Risk.
Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.
Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: a patient feasibility study.
Inhibition of aromatase expression by a psoralen-linked triplex-forming oligonucleotide targeted to a coding sequence.
Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol.
Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[a,l]pyrene in cells in culture.
Inhibitory effects of chrysoeriol on DNA adduct formation with benzo[a]pyrene in MCF-7 breast cancer cells.
Integrated safety analysis of rolapitant with coadministered drugs from phase II/III trials: an assessment of CYP2D6 or BCRP inhibition by rolapitant.
Interaction between genetic polymorphism of cytochrome P450-1B1 and environmental pollutants in breast cancer risk.
Interaction between smoking history and gene expression levels impacts survival of breast cancer patients.
Interaction of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferase M1 to breast cancer in Taiwanese woman without smoking and drinking habits.
Interaction potential of the endothelin-A receptor antagonist atrasentan with drug transporters and drug-metabolising enzymes assessed in vitro.
Interactions between genetic polymorphism of cytochrome P450-1B1, sulfotransferase 1A1, catechol-o-methyltransferase and tobacco exposure in breast cancer risk.
Interactions between tamoxifen and antidepressants via cytochrome P450 2D6.
Interest and attitudes of patients, cancer physicians, medical students and cancer researchers towards a spectrum of genetic tests relevant to breast cancer patients.
Interindividual variation in CYP1A1 expression in breast tissue and the role of genetic polymorphism.
Interrelationships between cyclooxygenases and aromatase: unraveling the relevance of cyclooxygenase inhibitors in breast cancer.
Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies.
Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer.
Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells.
Irinotecan pathway genotype analysis to predict pharmacokinetics.
Is aryl hydrocarbon hydroxylase activity a new prognostic indicator for breast cancer?
Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk.
Joint effects of the CYP1A1 MspI, ERalpha PvuII, and ERalpha XbaI polymorphisms on the risk of breast cancer: results from a population-based case-control study in Shanghai, China.
Laboratory testing of CYP2D6 alleles in relation to tamoxifen therapy.
Lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment.
Lack of Association between CYP1A1 M2 and M4 Polymorphisms and Breast Carcinoma in Jordanian Women: a Case-Control Study.
Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics.
Lack of significant association between CYP1A1 T3801C polymorphism and breast cancer risk: a meta-analysis involving 25,087 subjects.
Leptin induces CYP1B1 expression in MCF-7 cells through ligand-independent activation of the ER? pathway.
Lessons for pharmacogenomics studies: association study between CYP2D6 genotype and tamoxifen response.
Letrozole : in postmenopausal hormone-responsive early-stage breast cancer.
Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells.
Letrozole concentration is associated with CYP2A6 variation but not with arthralgia in patients with breast cancer.
Letrozole sensitizes breast cancer cells to ionizing radiation.
Ligands for the peroxisomal proliferator-activated receptor gamma and the retinoid X receptor inhibit aromatase cytochrome P450 (CYP19) expression mediated by promoter II in human breast adipose.
Limitations in Adjuvant Breast Cancer Therapy: The Predictive Potential of Pharmacogenetics and Pharmacogenomics.
Limited predictive value of achieving beneficial plasma (Z)-endoxifen threshold level by CYP2D6 genotyping in tamoxifen-treated Polish women with breast cancer.
Long-term exposure of 4-hydroxyestradiol induces the cancer cell characteristics via upregulating CYP1B1 in MCF-10A cells.
Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for tamoxifen pharmacogenetic studies.
Low CYP24A1 mRNA expression and its role in prognosis of breast cancer.
Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation.
Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.
Mammary-specific ablation of Cyp24a1 inhibits development, reduces proliferation and increases sensitivity to vitamin D.
Marked heterogeneity of aromatase activity in human malignant melanoma tissue.
Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice.
Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells.
Mechanisms and Predictions of Drug-Drug Interactions of the Hepatitis C Virus Three Direct-Acting Antiviral Regimen: Paritaprevir/Ritonavir, Ombitasvir, and Dasabuvir.
Medicinal Cannabis-Potential Drug Interactions.
Melatonin receptors, melatonin metabolizing enzymes and cyclin D1 in human breast cancer.
Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review.
Meta-analysis of genetic polymorphisms in xenobiotic metabolizing enzymes and their association with breast cancer risk.
Metabolic-Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib.
Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human cytochrome P4501B1.
Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.
Methanol extract of the ethnopharmaceutical remedy Smilax spinosa exhibits anti-neoplastic activity.
Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen).
Modulating Effect of Hypnea musciformis (Red Seaweed) on Lipid Peroxidation, Antioxidants and Biotransforming Enzymes in 7,12-Dimethylbenz (a) Anthracene Induced Mammary Carcinogenesis in Experimental Animals.
Modulating potential of L-sulforaphane in the expression of cytochrome p450 to identify potential targets for breast cancer chemoprevention and therapy using breast cell lines.
Modulation of CYP1A1, CYP1A2 and CYP1B1 Expression by Cabbage Juices and Indoles in Human Breast Cell Lines.
Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism.
Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism.
Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer.
Molecular pharmacology of aromatase and its regulation by endogenous and exogenous agents.
Multi-gene and Drug Interaction Approach for Tamoxifen Metabolite Patterns Reveals Possible Involvement of CYP2C9, CYP2C19 and ABCB1.
Mutation and protein expression analysis of CYP1A1 gene-a study on female breast cancer cases from India.
NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1.
Napabucasin Drug-Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers.
No association between a single nucleotide polymorphism in CYP19 and breast cancer risk.
No association between CYP1B1 Val432Leu polymorphism and breast cancer risk: a meta-analysis involving 40,303 subjects.
No association between CYP2D6*10 genotype and survival of node-negative Japanese breast cancer patients receiving adjuvant tamoxifen treatment.
No association found between CYP2D6 genotype and early breast cancer events in tamoxifen-treated patients.
No associations between aromatase gene polymorphisms and breast cancer risk in Saudi patients.
No increase in breast cancer recurrence with concurrent use of tamoxifen and some CYP2D6-inhibiting medications.
Nobiletin bioactivation in MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes.
Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice.
Nonsteroidal aromatase inhibitors: recent advances.
Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines.
Organization of the human aromatase p450 (CYP19) gene.
Oroxylin A, a methylated metabolite of baicalein, exhibits a stronger inhibitory effect than baicalein on the CYP1B1-mediated carcinogenic estradiol metabolite formation.
Overexpression of G6PD is associated with high risks of recurrent metastasis and poor progression-free survival in primary breast carcinoma.
Paclitaxel Nanoparticles Induce Apoptosis and Regulate TXR1, CYP3A4 and CYP2C8 in Breast Cancer and Hepatoma Cells.
Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese.
Pairwise combinations of estrogen metabolism genotypes in postmenopausal breast cancer etiology.
Pathological characteristics, survival, and risk of breast cancer associated with estrogen and xenobiotic metabolism polymorphisms in Mexican women with breast cancer.
Patients' understanding of how genotype variation affects benefits of tamoxifen therapy for breast cancer.
Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma.
Peroxisome proliferator-activated receptor ? (PPAR?)-cytochrome P450 epoxygenases-soluble epoxide hydrolase axis in ER?+?PR?+?HER2- breast cancer.
Personalized medicine in breast cancer: tamoxifen, endoxifen, and CYP2D6 in clinical practice.
Personalized participatory medicine: sharing knowledge and uncertainty.
Pharmacogenetic analysis of paclitaxel transport and metabolism genes in breast cancer.
Pharmacogenetic testing in the face of unclear clinical efficacy: Lessons from cytochrome P450 2D6 for tamoxifen.
Pharmacogenetics and breast cancer endocrine therapy: CYP2D6 as a predictive factor for tamoxifen metabolism and drug response?
Pharmacogenetics in breast cancer: steps toward personalized medicine in breast cancer management.
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Pharmacogenetics of aromatase inhibitors in endocrine responsive breast cancer: lessons learnt from tamoxifen and CYP2D6 genotyping.
Pharmacogenetics of endocrine therapy for breast cancer.
Pharmacogenetics of solid tumors: directed therapy in breast, lung, and colorectal cancer: a paper from the 2008 william beaumont hospital symposium on molecular pathology.
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes.
Pharmacogenomic variation of CYP2D6 and the choice of optimal adjuvant endocrine therapy for postmenopausal breast cancer: a modeling analysis.
Pharmacogenomics of breast cancer: highlighting CYP2D6 and tamoxifen.
Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects.
Pharmacogenomics of tamoxifen and irinotecan therapies.
Pharmacogenomics of tamoxifen: roles of drug metabolizing enzymes and transporters.
Pharmacogenomics toward personalized tamoxifen therapy for breast cancer.
Pharmacogenomics, CYP2D6, and Tamoxifen: A Survey of the Reasons Sustaining European Clinical Practice Paradigms.
Pharmacokinetic drug interactions between ondansetron and tamoxifen in female Sprague-Dawley rats with DMBA-induced mammary tumor.
Pharmacokinetic Drug-Drug Interaction of Apalutamide, Part 1: Clinical Studies in Healthy Men and Patients with Castration-Resistant Prostate Cancer.
Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, in vitro.
Pharmacokinetic properties of wogonin and its herb-drug interactions with docetaxel in rats with mammary tumors.
Pharmacokinetics of cyclophosphamide enantiomers in patients with breast cancer.
Pharmacokinetics of endoxifen and tamoxifen in female mice: implications for comparative in vivo activity studies.
Pharmacological relevance of endoxifen in a laboratory simulation of breast cancer in postmenopausal patients.
Pharmacophore modeling and in silico screening for new P450 19 (aromatase) inhibitors.
Physiologically Based Pharmacokinetic Modeling of Tamoxifen and its Metabolites in Women of Different CYP2D6 Phenotypes Provides New Insight into the Tamoxifen Mass Balance.
Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age.
Plasma membrane localization of CYP4Z1 and CYP19A1 and the detection of anti-CYP19A1 autoantibodies in humans.
Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study.
Polychlorinated biphenyls, cytochrome P450 1A1, and breast cancer risk in the Nurses' Health Study.
Polychlorinated biphenyls, cytochrome P4501A1 polymorphism, and postmenopausal breast cancer risk.
Polymorphic variation in CYP19 and the risk of breast cancer.
Polymorphism in xenobiotic and estrogen metabolizing genes, exposure to perfluorinated compounds and subsequent breast cancer risk: A nested case-control study in the Danish National Birth Cohort.
Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.
Polymorphism of the CYP2D6 gene in women with breast cancer treated with tamoxifen.
Polymorphism of the cytochrome P-450 1A1 (A2455G) in women with breast cancer in Eastern Azerbaijan, Iran.
Polymorphism of Xenobiotic-Metabolizing Genes and Breast Cancer Susceptibility in North Indian Women.
Polymorphisms associated with circulating sex hormone levels in postmenopausal women.
Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women.
Polymorphisms in CYP1A1 and smoking: no association with breast cancer risk.
Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer.
Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients.
Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast cancer.
Polymorphisms in estrogen biosynthesis and metabolism-related genes, ionizing radiation exposure, and risk of breast cancer among US radiologic technologists.
Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease.
Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.
Polymorphisms in Phase I (CYP450) Genes CYP1A1 (rs4646421), CYP1B1 (rs1056836), CYP19A1 (rs749292) and CYP2C8 (rs1058930) and Their Relation to Risk of Breast Cancer: A Case-Control Study in Mazandaran Province in North of Iran.
Polymorphisms in the human aromatase cytochrome P450 gene (CYP19) and breast cancer risk.
Polymorphisms in Xenobiotic Metabolizing Genes, Intakes of Heterocyclic Amines and Red Meat, and Postmenopausal Breast Cancer.
Polymorphisms of catechol estrogens metabolism pathway genes and breast cancer risk in Mexican women.
Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.
Polymorphisms of estrogen synthesizing and metabolizing genes and breast cancer risk in Japanese women.
Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
Population-based case-control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer risk.
Positive selection in the evolution of cancer.
Possible difference in frequencies of genetic polymorphisms of estrogen receptor alpha, estrogen metabolism and P53 genes between estrogen receptor-positive and -negative breast cancers.
Possible Risk Modification by Polymorphisms of Estrogen Metabolizing Genes in Familial Breast Cancer Susceptibility in an Indian Population.
Potent CYP2D6 Inhibiting drugs do not increase relapse rate in early breast cancer patients treated with adjuvant tamoxifen.
Potential Benefits of Pre-emptive PGx Testing in Male Breast Cancer Patients.
Potential differences in breast cancer risk factors based on CYP1A1 MspI and African-American-specific genotypes.
Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate.
Predicting steady-state endoxifen plasma concentrations in breast cancer patients by CYP2D6 genotyping or phenotyping. Which approach is more reliable?
Prediction of tamoxifen outcome by genetic variation of CYP2D6 in postmenopausal women with early breast cancer.
Predictive pharmacogenetic biomarkers for breast cancer recurrence prevention by simvastatin.
Preferential induction of CYP1A1 over CYP1B1 in human breast cancer MCF-7 cells after exposure to berberine.
Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin.
Prevalence of CYP2D6*2, CYP2D6*4, CYP2D6*10, and CYP3A5*3 in Thai breast cancer patients undergoing tamoxifen treatment.
Prevalence of the co-prescription of tamoxifen and CYP2D6 inhibitors in Saudi population: A cross sectional study.
Prevalent breast cancer patients with a homozygous mutant status for CYP2D6*4: response and biomarkers in tamoxifen users.
Preventive medical services not covered by public health insurance at Daiko Medical Center in Japan, 2004-2011.
Primary breast tumor levels of suspected molecular determinants of cellular sensitivity to cyclophosphamide, ifosfamide, and certain other anticancer agents as predictors of paired metastatic tumor levels of these determinants. Rational individualization of cancer chemotherapeutic regimens.
Prioritizing pharmacogenetic research: a value of information analysis of CYP2D6 testing to guide breast cancer treatment.
Profiling the expression of cytochrome P450 in breast cancer.
Profound reduction in tamoxifen active metabolite endoxifen in a breast cancer patient treated with rifampin prior to initiation of an anti-TNF? biologic for ulcerative colitis: a case report.
Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.
Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells.
Protein kinase A-dependent synergism between GATA factors and the nuclear receptor, liver receptor homolog-1, regulates human aromatase (CYP19) PII promoter activity in breast cancer cells.
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.
Racial differences in drug metabolism: an explanation for higher breast cancer mortality in blacks?
Rapid point-of-care breath test for biomarkers of breast cancer and abnormal mammograms.
RE Damkier: CYP2D6 genotyping and tamoxifen in the treatment of postmenopausal breast cancer.
Re: CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women With Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial and Re: CYP2D6 and UGT2B7 Genotype and Risk of Recurrence in Tamoxifen-Treated Breast Cancer Patients.
Re: CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women With Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial.
Re: CYP2D6 genotyping and the use of tamoxifen in breast cancer.
Re: Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
Re: Pharmacogenomic variation of CYP2D6 and the choice of optimal adjuvant endocrine therapy for postmenopausal breast cancer: a modeling analysis.
Reactivation of Estrogen Receptor ? by Vorinostat Sensitizes Mesenchymal-Like Triple-Negative Breast Cancer to Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor.
Real-time reverse transcription PCR assay of CYP19 expression: application to a well-defined series of post-menopausal breast carcinomas.
Recombinant antibody piezoimmunosensors for the detection of cytochrome P450 1B1.
Recruitment of monocytes and epigenetic silencing of intratumoral CYP7B1 primarily contribute to the accumulation of 27-hydroxycholesterol in breast cancer.
Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism.
Reductive amination-assisted quantitation of tamoxifen and its metabolites by liquid phase chromatography tandem mass spectrometry.
Regioselective hydroxylation of steroid hormones by human cytochromes P450.
Regulated CYP19 aromatase transcription in breast stromal fibroblasts.
Regulation of aromatase induction by nuclear receptor coregulator PELP1.
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Regulation of cytochrome P450 gene expression in human colon and breast tumour xenografts.
Relation between cytochrome P450IA1 expression and estrogen receptor content of human breast cancer cells.
Relationship between aromatase and cyclooxygenases in breast cancer: potential for new therapeutic approaches.
Relationship between CYP1A1 polymorphisms and invasion and metastasis of breast cancer.
Relationship between genotypes Sult1a2 and Cyp2d6 and tamoxifen metabolism in breast cancer patients.
Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma.
Relationship of CYP2D6 (debrisoquine hydroxylase) genotype to breast cancer susceptibility.
Relationships between CYP2D6 phenotype, breast cancer and hot flushes in women at high risk of breast cancer receiving prophylactic tamoxifen: results from the IBIS-I trial.
Relative imbalances in the expression of catechol-O-methyltransferase and cytochrome P450 in breast cancer tissue and their association with breast carcinoma.
Representation of CYP3A4, CYP3A5 and UGT1A4 Polymorphisms within Croatian Breast Cancer Patients' Population.
Resonance Raman Spectroscopy of the Oxygenated Intermediates of Human CYP19A1 Implicates a Compound I Intermediate in the Final Lyase Step.
Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor.
Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the Aryl Hydrocarbon Receptor complex and RNA Polymerase II to the regulatory regions of the corresponding genes.
RNA expression of cytochrome P450 in breast cancer patients.
RNA expression of cytochrome p450 in mexican women with breast cancer.
Role and pharmacologic significance of cytochrome P-450 2D6 in oxidative metabolism of toremifene and tamoxifen.
Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development.
Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells.
Role of CYP1A2 polymorphisms in breast cancer risk in women.
Role of CYP2D6 testing in selection of endocrine therapy for breast cancer.
Role of CYP2E1 polymorphisms in breast cancer: a systematic review and meta-analysis.
Role of cytochrome P450 genes in breast cancer etiology and treatment: effects on estrogen biosynthesis, metabolism, and response to endocrine therapy.
Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk.
Role of Genetic Variation in Cytochromes P450 in Breast Cancer Prognosis and Therapy Response.
Role of melatonin in the epigenetic regulation of breast cancer.
Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers.
Role of pharmacogenetics on adjuvant chemotherapy-induced neutropenia in Chinese breast cancer patients.
Role of polymorphic human cytochrome p450 enzymes in estrone oxidation.
Role of Polymorphisms of FAM13A, PHLDB1, and CYP24A1 in Breast Cancer Risk.
Role of the CYP3A4-mediated 11,12-epoxyeicosatrienoic acid pathway in the development of tamoxifen-resistant breast cancer.
Role of the progesterone receptor (PR) in the regulation of inflammatory response pathways and aromatase in the breast.
Role of xenobiotic metabolizing gene polymorphisms in breast cancer susceptibility and treatment outcome.
Roles of coactivator proteins in dioxin induction of CYP1A1 and CYP1B1 in human breast cancer cells.
RRM1, TUBB3, TOP2A, CYP19A1, CYP2D6: Difference between mRNA and protein expression in predicting prognosis of breast cancer patients.
S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling.
Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast Cancer.
Selective inhibition of methoxyflavonoids on human CYP1B1 activity.
Selective regulation of aromatase expression for drug discovery.
Self-packed core shell nano liquid chromatography columns and silica-based monolithic trap columns for targeted proteomics.
Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.
Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients.
Serum concentrations of tamoxifen and its metabolites increase with age during steady-state treatment.
Serum polychlorinated biphenyls, cytochrome P-450 1A1 polymorphisms, and risk of breast cancer in Connecticut women.
Should CYP2D6 be genotyped when treating with tamoxifen?
Should CYP2D6 inhibitors be administered in conjunction with tamoxifen?
Shu-Gan-Liang-Xue Decoction Simultaneously Down-regulates Expressions of Aromatase and Steroid Sulfatase in Estrogen Receptor Positive Breast Cancer Cells.
Side effects after docetaxel treatment in Taiwanese breast cancer patients with CYP3A4, CYP3A5, and ABCB1 gene polymorphisms.
Side effects associated with ultrarapid cytochrome P450 2D6 genotype among women with early stage breast cancer treated with tamoxifen.
Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells.
Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients.
Simple tandem repeat (TTTA)n polymorphism in CYP19 (aromatase) gene and breast cancer risk in Nigerian women.
Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D6 genotypes.
Single-nucleotide polymorphisms and mRNA expression of CYP1B1 influence treatment response in triple negative breast cancer patients undergoing chemotherapy.
Sources of estrogen and their importance.
Soy Isoflavones, CYP1A1, CYP1B1, and COMT Polymorphisms, and Breast Cancer: A Case-Control Study in Southwestern China.
ssociation of Cytochrome P450-1B1 Gene Polymorphisms with Risk of Breast Cancer: an Egyptian Study.
Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis.
Steroidogenic effect of Erxian decoction for relieving menopause via the p-Akt/PKB pathway in vitro and in vivo.
Structure of an activity suppressing Fab fragment to cytochrome P450 aromatase: insights into the antibody-antigen interactions.
Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor.
Studies on CYP1A1, CYP1B1 and CYP3A4 gene polymorphisms in breast cancer patients.
Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells.
Study of the frequencies of CYP1A1 gene polymorphisms and glutathione S-transferase mu1 gene in primary breast cancers: an update with an additional 114 cases.
Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists.
Sunitinib, a tyrosine kinase inhibitor, induces cytochrome P450 1A1 gene in human breast cancer MCF7 cells through ligand-independent aryl hydrocarbon receptor activation.
Sunlight, polymorphisms of vitamin D-related genes and risk of breast cancer.
Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists.
Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones.
Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone.
Synthesis, Aromatase Inhibitory, Antiproliferative and Molecular Modeling Studies of Functionally Diverse D-Ring Pregnenolone Pyrazoles.
Synthesis, structure elucidation, and biochemical evaluation of 7 alpha- and 7 beta-arylaliphatic-substituted androst-4-ene-3,17-diones as inhibitors of aromatase.
Tailoring adjuvant endocrine therapy for postmenopausal breast cancer: a CYP2D6 multiple-genotype-based modeling analysis and validation.
Tamoxifen and depression: drug interactions in breast cancer.
Tamoxifen Benefits and CYP2D6 Testing in Women With Hormone Receptor-Positive Breast Cancer.
Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients.
Tamoxifen metabolism in breast cancer treatment: Taking the focus off the CYP2D6 gene.
Tamoxifen Metabolite Concentrations, CYP2D6 Genotype, and Breast Cancer Outcomes.
Tamoxifen Pharmacogenetics and Metabolism: Results From the Prospective CYPTAM Study.
Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response.
Tamoxifen Resistance and CYP2D6 Copy Numbers in Breast Cancer Patients.
Tamoxifen use in postmenopausal breast cancer: CYP2D6 matters.
Tamoxifen, cytochrome P450 genes and breast cancer clinical outcomes.
Targeted Multiplex Imaging Mass Spectrometry with Single Chain Fragment Variable (scfv) Recombinant Antibodies.
Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential.
Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development.
Tetra-methoxystilbene modulates ductal growth of the developing murine mammary gland.
The androgen metabolite 5alpha-androstane-3beta,17beta-diol (3betaAdiol) induces breast cancer growth via estrogen receptor: implications for aromatase inhibitor resistance.
The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer.
The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.
The association between genetic polymorphisms in CYP19 and breast cancer risk in Korean women.
The association between genetic variants in the genes for cytochrome P450 B1 and ATP-binding cassette transporter genes and breast cancer risk.
The association of CYP2D6 *10 polymorphism with breast cancer risk and clinico-pathologic characteristics in Chinese women.
The associations of genetic polymorphisms in CYP1A2 and CYP3A4 with clinical outcomes of breast cancer patients in northern China.
The clinical effectiveness and cost-effectiveness of genotyping for CYP2D6 for the management of women with breast cancer treated with tamoxifen: a systematic review.
The CYP17 and CYP19 gene single nucleotide polymorphism in women with sporadic breast cancer.
The CYP19 gene codon 39 Trp/Arg polymorphism increases breast cancer risk in subsets of premenopausal Japanese.
The CYP19 RS4646 polymorphism IS related to the prognosis of stage I-II and operable stage III breast cancer.
The CYP19 TTTA repeat polymorphism is related to the prognosis of premenopausal stage I-II and operable stage III breast cancers.
The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers.
The CYP1B1_1358_GG genotype is associated with estrogen receptor-negative breast cancer.
The CYP2D6*4 polymorphism affects breast cancer survival in tamoxifen users.
The detoxification responses, damage effects and bioaccumulation in the scallop Chlamys farreri exposed to single and mixtures of benzo[a]pyrene and chrysene.
The direct proliferative stimulus of dehydroepiandrosterone on MCF7 breast cancer cells is potentiated by overexpression of aromatase.
The Discriminatory Value of CYP2D6 Genotyping in Predicting the Dextromethorphan/Dextrorphan Phenotype in Women with Breast Cancer.
The Drug-Drug Interaction Profile of Presatovir.
The effect analysis of CYP2D6 gene polymorphism in the toremifene and tamoxifen treatment in patient with breast cancer.
The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate.
The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells.
The Effects of Sex Protein Receptors and Sex Steroid Hormone Gene Polymorphisms on Breast Cancer Risk.
The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue.
The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor.
The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-?B-driven tumour intravasation.
The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters.
The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene.
The impact of CYP2D6-predicted phenotype on tamoxifen treatment outcome in patients with metastatic breast cancer.
The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen.
The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.
The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)-Endoxifen in Breast Cancer.
The phospholipidosis-lnducing potential of the chemopotentiating drug, N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE, tesmilifene) correlates with its stimulation of phosphatidylserine synthesis and exposure on the plasma membrane in MCF-7 breast cancer cells.
The prognostic values of CYP2B6 genetic polymorphisms and metastatic sites for advanced breast cancer patients treated with docetaxel and thiotepa.
The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression.
The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells.
The redox protein thioredoxin-1 regulates the constitutive and inducible expression of the estrogen metabolizing cytochromes P450 1B1 and 1A1 in MCF-7 human breast cancer cells.
The relationship between the CYP2D6 polymorphisms and tamoxifen efficacy in adjuvant endocrine therapy of breast cancer patients in Chinese Han population.
The Risk of Recurrence in Breast Cancer Patients Treated with Tamoxifen: Polymorphisms of CYP2D6 and ABCB1.
The role of aromatase and 17-beta-hydroxysteroid dehydrogenase type 1 mRNA expression in predicting the clinical outcome of human breast cancer.
The Role of CYP2D6 Polymorphisms in Determining Response to Tamoxifen in Metastatic Breast Cancer Patients: Review and Egyptian Experience.
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
The role of pregnane x receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice.
The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells.
The synergistic effect between adult weight changes and CYP24A1 polymorphisms is associated with pre- and postmenopausal breast cancer risk.
The synthesis of 4,6-diaryl-2-pyridones and their bioactivation in CYP1 expressing breast cancer cells.
The synthesis of chalcones as anticancer prodrugs and their bioactivation in CYP1 expressing breast cancer cells.
The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells.
The use of the (13)C-dextromethorphan breath test for phenotyping CYP2D6 in breast cancer patients using tamoxifen: association with CYP2D6 genotype and serum endoxifen levels.
Therapeutic Drug Monitoring of endoxifen as an alternative for CYP2D6 genotyping in individualizing tamoxifen therapy.
Three polymorphisms in cytochrome P450 1B1 (CYP1B1) gene and breast cancer risk: a meta-analysis.
Three-dimensional quantitative structure-activity relationships of steroid aromatase inhibitors.
Time and dose-dependent modulation of phase 1 and phase 2 gene expression in response to treatment of MCF-7 cells with a natural anti-cancer agent.
Toremifene, rather than tamoxifen, might be a better option for the adjuvant endocrine therapy in CYP2D6*10T/T genotype breast cancer patients in China.
Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data.
Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1.
Transcriptional activation of the porcine P450 11A insulin-like growth factor response element in MCF-7 breast cancer cells.
Transcriptional control of human cytochrome P1-450 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human tissue culture cell lines.
Transcriptomic analysis of an in vitro murine model of ovarian carcinoma: Functional similarity to the human disease and identification of prospective tumoral markers and targets.
Transient induction of cytochromes P450 1A1 and 1B1 in MCF-7 human breast cancer cells by indirubin.
Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer.
Trends in co-prescribing of antidepressants and tamoxifen among women with breast cancer, 2004-2010.
Trichostatin A down-regulates CYP19 transcript and protein levels in MCF-7 breast cancer cells.
Understanding breast cancer risk -- where do we stand in 2005?
Urban Endocrine Disruptors Targeting Breast Cancer Proteins.
Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and genetic polymorphisms in breast cancer patients.
Urinary bisphenol A and its interaction with CYP17A1 rs743572 are associated with breast cancer risk.
Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients.
Usefulness of novobiocin as a selective inhibitor of intestinal breast cancer resistance protein (Bcrp) in rats.
Utility of a novel Oatp1b2 knockout mouse model for evaluating the role of Oatp1b2 in the hepatic uptake of model compounds.
Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3A.
Validation of real-time RT-PCR for analysis of human breast cancer cell lines resistant or sensitive to treatment with antiestrogens.
Variants in estrogen metabolism and biosynthesis genes and urinary estrogen metabolites in women with a family history of breast cancer.
Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study.
Variants of estrogen-related genes and breast cancer risk in European and African American women.
Vitamin D receptor (VDR) and metabolizing enzymes CYP27B1 and CYP24A1 in breast cancer.
Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages.
Vitamin D supplementation decreases serum 27-hydroxycholesterol in a pilot breast cancer trial.
Volatile biomarkers in the breath of women with breast cancer.
Whole genome amplification of DNA for genotyping pharmacogenetics candidate genes.
WY-14643 Regulates CYP1B1 Expression through Peroxisome Proliferator-Activated Receptor ?-Mediated Signaling in Human Breast Cancer Cells.
Xenobiotic metabolizing and antioxidant enzymes in normal and neoplastic human breast tissue.
Xenobiotic-metabolising enzymes in patients with adenocarcinoma of the breast: Correlation with clinical stage and menopausal status.
Zinc finger nuclease-mediated knockout of AHR or ARNT in human breast cancer cells abolishes basal and ligand-dependent regulation of CYP1B1 and differentially affects estrogen receptor ? transactivation.
[Advances in the research of pharmacogenomics of tamoxifen].
[Antagonism of tamoxifen and antidepressants among women with breast cancer].
[Aromatase gene expression and its modifying factors in breast tumor tissue]
[Aromatase--key enzyme of estrogen biosynthesis]
[Association of polymorphism of genetic markers of CYP19 and CYP17 with sporadic breast cancer]
[CYP2D6 polymorphisms and tamoxifen: therapeutic perspectives in the management of hormonodependent breast cancer patients]
[Genetic polymorphism and variability of steroid hormone metabolism: connection with risk of developing breast neoplasms]
[Genetic polymorphism of steroidogenic enzymes and steroid receptor level in tumors of the reproductive system]
[Growth inhibition and multidrug resistance-reversing effect of tanshinone I A on human breast cancer cell with estrogen receptor negative]
[Polymorphisms of CYP1B1 and COMT in breast and endometrial cancer]
[Relationship between estrogen-biosynthesis gene (CYP17, CYP19, HSD17beta1) polymorphisms and breast cancer]
[Study of cytochrome P450 1A1 gene 3'-UTR 6235T-C polymorphism and susceptibility to breast cancer with Uighur medicine].
[Study on serum organochlorines pesticides (DDTs) level, CYP1A1 genetic polymorphism and risk of breast cancer: a case control study]
[Study on the association between CYP24A1 genetic polymorphisms and risks related to postmenopausal breast cancer].
[Study on the relationship between polymorphisms of genes (CYP17, CYP19 and SULT1A1) and susceptibility to breast cancer in Chinese women]
[The drug-drug interaction mediated by efflux transporters and CYP450 enzymes].
[The polymorphism of genes of synthesis and metabolism of estrogens and the risk of breast cancer].
Breast Neoplasms, Male
A polymorphic tetranucleotide repeat in the CYP19 gene and male breast cancer.
Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk.
Bronchitis
[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]
Bronchitis, Chronic
Clinical features of chronic bronchitis and genetic risk factors for the development of chronic obstructive pulmonary disease in adolescent smokers.
Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children.
Lack of relation between genetic polymorphism of cytochrome P-450IID6 and sporadic idiopathic Parkinson's disease.
The relationship of host factors to the pathogenesis of chronic bronchitis and obstructive airway disease: lymphoblast aryl hydrocarbon hydroxylase.
Bronchopulmonary Dysplasia
GSTP1 and CYP2B6 Genetic Polymorphisms and the Risk of Bronchopulmonary Dysplasia in Preterm Neonates.
Newborn mice lacking the gene for Cyp1a1 are more susceptible to oxygen-mediated lung injury, and are rescued by postnatal ?-napthoflavone (BNF) administration: Implications for bronchopulmonary dysplasia (BPD) in premature infants.
Brucellosis
[Effects of rifampicin on the pharmacodynamics of doxycycline]
Budd-Chiari Syndrome
Mutations in CYP2C9 and/or VKORC1 haplotype are associated with higher bleeding complications in patients with Budd-Chiari syndrome on warfarin.
Callosities
[Study on the relationship between familial clustering of hepatocellular carcinoma and polymorphism of cytochrome P450 2E1 gene in Zhuang population, Guangxi]
Candidiasis
[Experimental study and clinical application of rapid diagnosis of systemic candida albicans infection in burns by polymerase chain reaction]
Carcinogenesis
(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent.
12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells.
2,3,7,8-tetrachlorodibenzo-p-dioxin induces CYP1B1 expression in human luteinized granulosa cells.
5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells.
6-Prenylnaringenin from Hops Disrupts ER?-mediated Downregulation of CYP1A1 to Facilitate Estrogen Detoxification.
A Case-Control and a Family-Based Association Study Revealing an Association between CYP2E1 Polymorphisms and Nasopharyngeal Carcinoma Risk in Cantonese.
A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach.
A CRISPR/Cas9 Whole-Genome Screen Identifies Genes Required for Aryl Hydrocarbon Receptor-Dependent Induction of Functional CYP1A1.
A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction.
A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma.
A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis.
A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis.
A transgenic mouse expressing human CYP1A2 in the pancreas.
Action of curcumin on the cytochrome P450-system catalyzing the activation of aflatoxin B1.
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.
Alcohol and cancer: an overview with special emphasis on the role of acetaldehyde and cytochrome P450 2E1.
Alcohol and Cancer: Mechanisms and Therapies.
Alcohol and pancreatic cancer.
Alcohol consumption and cancer of the gastrointestinal tract.
Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.
Alkylation of cellular macromolecules and target specificity of carcinogenic nitrosodialkylamines: metabolic activation by cytochromes P450 2B1 and 2E1.
Alterations in ubiquitin ligase Siah-2 and its corepressor N-CoR after P-MAPA immunotherapy and anti-androgen therapy: new therapeutic opportunities for non-muscle invasive bladder cancer.
An alternatively spliced cytochrome P4501A1 in human brain fails to bioactivate polycyclic aromatic hydrocarbons to DNA-reactive metabolites.
Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase (MPO), quinone oxidoreductase (NQO1), and glutathione S-transferases (GSTs).
Analysis of chloroethane toxicity and carcinogenicity including a comparison with bromoethane.
Analysis of CYP1A1 induction in single cells of urothelial cell populations by flow cytometry.
Animal models in carotenoids research and lung cancer prevention.
Anti-carcinogenic potential of Euphorbia neriifolia leaves and isolated flavonoid against N-nitrosodiethylamine-induced renal carcinogenesis in mice.
Antioxidant enzymes in ciprofibrate-induced oxidative stress.
Aryl hydrocarbon hydroxylase and polycyclic hydrocarbon tumorigenesis: effect of the enzyme inhibitor 7,8-benzoflavone on tumorigenesis and macromolecule binding.
Aryl hydrocarbon hydroxylase in mouse mammary gland.
Aryl hydrocarbon hydroxylase, epoxide hydrase, and 7,12-dimethylbenz(a)anthracene-produced skin tumorigenesis in the mouse.
Aryl hydrocarbon receptor plays a significant role in mediating airborne particulate-induced carcinogenesis in mice.
Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice.
Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer.
Association of CYP1B1 polymorphisms and breast cancer risk.
Association of mitochondrial deoxyribonucleic acid mutation with polymorphism in CYP2E1 gene in oral carcinogenesis.
Association study between CYP24A1 gene polymorphisms and cancer risk.
Azadirachta indica leaf extract modulates initiation phase of murine forestomach tumorigenesis.
Azadirachta indica modulates carcinogen biotransformation and reduced glutathione at peri-initiation phase of benzo(a)pyrene induced murine forestomach tumorigenesis.
Benzo[g,h,i]perylene synergistically transactivates benzo[a]pyrene-induced CYP1A1 gene expression by aryl hydrocarbon receptor pathway.
Betel quid containing safrole enhances metabolic activation of tobacco specific 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (A?C) in human bladder RT4 cells.
Biologic markers in cancer diagnosis and treatment.
Cancer phytotherapeutics: role for flavonoids at the cellular level.
Cancer prevention by bovine lactoferrin and underlying mechanisms--a review of experimental and clinical studies.
Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential.
Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2.
Characterization of a wound-inducible cytochrome P450 gene ( CYP72A29) that is down-regulated during crown gall tumorigenesis in potato tuber.
Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism.
Chemoprevention of 2-amino-1-methyl-6-phenyli-midazo 4,5-b pyridine-induced carcinogen-DNA adducts by Chinese cabbage in rats.
Chemopreventive potential of thiol conjugates of isothiocyanates for lung cancer and a urinary biomarker of dietary isothiocyanates.
Co-carcinogenic effect of cyclohexanol on the development of preneoplastic lesions in a rat hepatocarcinogenesis model.
Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.
Comparative Expression Analysis of Cytochrome P450 1A1, Cytochrome P450 1B1 and Nuclear Receptors in the Female Genital and Colorectal Tissues of Human and Pigtailed Macaque.
Comparative Levels of O6-Methylguanine, Pyridyloxobutyl-, and Pyridylhydroxybutyl-DNA Adducts in Lung and Liver of Rats Treated Chronically with the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
Comparison of rat hepatocyte and differentiated hepatoma cell line cultures as bio indicators of CYP 1A1 inducers in urban air.
Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues.
Comprehensive computational target fishing approach to identify Xanthorrhizol putative targets.
Constitutive expression and localization of cytochrome P-450 1A1 in rat and human brain: presence of a splice variant form in human brain.
Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue.
Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis.
Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT.
CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies.
CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis.
CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case-control study.
CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm.
CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case-control study within a large-scale population-based prospective study.
CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations.
CYP1A2 164 A-->C polymorphism, cigarette smoking, consumption of well-done red meat and risk of developing colorectal adenomas and carcinomas.
CYP1B1 and hormone-induced cancer.
Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates.
CYP1B1 gene in endometrial cancer.
CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma.
CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers.
CYP24A1 and CYP27B1 Polymorphisms Modulate Vitamin D Metabolism in Colon Cancer Cells.
CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells.
CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload.
CYP2E1 polymorphisms and gene-environment interactions in the risk of upper aerodigestive tract cancers among Indians.
CYP2E1 rs2031920, COMT rs4680 Polymorphisms, Cigarette Smoking, Alcohol Use and Lung Cancer Risk in a Japanese Population.
CYP2F1 genetic polymorphism: Identification of interethnic variations.
CYP3A5 suppresses metastasis of lung adenocarcinoma through ATOH8/Smad1 axis.
Cytochrome P-450 and acetyltransferase expression as biomarkers of carcinogen-DNA adduct levels and human cancer susceptibility.
Cytochrome P1B1 (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis.
Cytochrome P450 1B1 (CYP1B1) gene polymorphisms as predictors of anticancer drug activity: studies with in vitro models.
Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.
Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux.
Cytochrome P450 1B1 gene polymorphisms and postmenopausal endometrial cancer risk.
Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse.
Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation.
Cytochrome P450 1B1 polymorphisms and risk of renal cell carcinoma in men.
Cytochrome P450 1B1 promotes cancer cell survival via specificity protein 1 (Sp1)-mediated suppression of death receptor 4.
Cytochrome P450 1B1, a new keystone in gene-environment interactions related to human head and neck cancer?
Cytochrome P450 1B1, a novel chemopreventive target for benzo[a]pyrene-initiated human esophageal cancer.
Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies.
Cytochrome P450 2A13 mediates the neoplastic transformation of human bronchial epithelial cells at a low concentration of aflatoxin B1.
Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells.
Cytochrome P450 2E1 DraI polymorphisms in lung cancer in minority populations.
Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats.
Cytochrome P450 2E1: Its Clinical Aspects and a Brief Perspective on the Current Research Scenario.
Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.
Cytochrome P450 Eicosanoid Signaling Pathway in Colorectal Tumorigenesis.
Cytochrome P450 isoforms. Regulation during infection, inflammation and by cytokines.
Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma.
Cytochrome P450 Mediated Pulmonary Metabolism of Carcinogens: Regulation and Cross-talk in Lung Carcinogenesis.
Cytotoxicity and genotoxicity of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol in CYP1A1-expressing human fibroblasts quantitatively correlate with CYP1A1 expression level.
D15 Effects of acetylsalicylic acid administration on liver CYP1A, UGT and antioxidant enzymes in a rat model of dimethylbenzanthracene (DMBA)-induced mammary carcinogenesis.
Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma.
Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma.
Degradation of benzo[a]pyrene by bacterial isolates from human skin.
Detection and Quantification of Specific DNA Adducts by Liquid Chromatography-Tandem Mass Spectrometry in the Livers of Rats Given Estragole at the Carcinogenic Dose.
Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture.
Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.
Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of the aryl hydrocarbon receptor.
Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China.
Dietary protein, aryl hydrocarbon hydroxylase and chemical carcinogenesis in rats.
Dietary soya isoflavones and breast carcinogenesis: a perspective from a cell-culture model.
Differences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolites.
Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high-altitude adaptation.
Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes.
Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.
Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.
Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene.
Dimethylbenzanthracene tumorigenesis and aryl hydrocarbon hydroxylase in mouse skin: inhibition by 7,8-benzoflavone.
Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo.
Distribution of soluble epoxide hydrolase, cytochrome P450 2C8, 2C9 and 2J2 in human malignant neoplasms.
Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis.
DNA damage caused by reactive oxygen species originating from a copper-dependent oxidation of the 2-hydroxy catechol of estradiol.
DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung.
Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice.
Down-regulation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats.
Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase.
Effect of carotenoid lutein on N-nitrosodiethylamine-induced hepatocellular carcinoma and its mechanism of action.
Effect of chronic dietary ethanol in the promotion of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats.
Effect of cigarette smoke on hepatic and pulmonary cytochromes P450 in mouse: evidence for CYP2E1 induction in lung.
Effect of cigarette smoke on mutagenic activation of environmental carcinogens by cytochrome P450 2A8 and inactivation by glucuronidation in hamster liver.
Effect of the co-administration of phenobarbital, quercetin and mancozeb on nitrosomethylurea-induced pancreatic tumors in rats.
Effect of troglitazone on CYP1A1 induction.
Effects of 3-methylcholanthrene on gene expression profiling in the rat using cDNA microarray analyses.
Effects of alpha-naphthyl isothiocyanate and a heterocyclic amine, PhIP, on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver.
Effects of citrus phytochemicals on liver and lung cytochrome P450 activity and on the in vitro metabolism of the tobacco-specific nitrosamine NNK.
Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism.
Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat.
Effects of diethyl maleate on aryl hydrocarbon hydroxylase and on 3-methyl-cholanthrene-induced skin tumorigenesis in rats and mice.
Effects of genetically different strains of mice on the microsomal activation of 2-aminofluorene.
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models.
Effects of natural polyphenols on aflatoxin B1 activation in a reconstituted microsomal monooxygenase system.
Effects of tobacco smoke on the gene expression of the Cyp1a, Cyp2b, Cyp2e, and Cyp3a subfamilies in mouse liver and lung: relation to single strand breaks of DNA.
Effects of watercress consumption on urinary metabolites of nicotine in smokers.
Eicosanoid signaling in carcinogenesis of colorectal cancer.
Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer.
Emamectin benzoate induced enzymatic and transcriptional alternation in detoxification mechanism of predatory beetle Paederus fuscipes (Coleoptera: Staphylinidae) at the sublethal concentration.
Enhancement of hepatocarcinogenesis and induction of specific cytochrome P450-dependent monooxygenase activities by the barbiturates allobarbital, aprobarbital, pentobarbital, secobarbital and 5-phenyl- and 5-ethylbarbituric acids.
Enhancement of thyroid and hepatocarcinogenesis by 1,4-bis[2-(3,5- dichloropyridyloxy)]benzene in rats at doses that cause maximal induction of CYP2B.
Enhancing effects of 2-amino-4,5-diphenylthiazole-induced polycystic kidneys on renal carcinogenesis in rats treated with dimethylnitrosamine.
Enhancing effects of a high fat diet on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced lung tumorigenesis in female A/J mice.
EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange.
Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test.
Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis.
Estrogen metabolite ratio: Is the 2-hydroxyestrone to 16?-hydroxyestrone ratio predictive for breast cancer?
Estrogen receptor alpha promotes smoking-carcinogen-induced lung carcinogenesis via cytochrome P450 1B1.
Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1.
Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions.
Evaluation of CYP1B1 Expression, Oxidative Stress and Phase 2 Detoxification Enzyme Status in Oral Squamous Cell Carcinoma Patients.
Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.
Evidence for CYP2D6 expression in human lung.
Exposing ferrets to cigarette smoke and a pharmacological dose of beta-carotene supplementation enhance in vitro retinoic acid catabolism in lungs via induction of cytochrome P450 enzymes.
Expression and induction of cytochrome P-450 1A1 and P-450 2D subfamily in the rat glioma C6 cell line.
Expression and localization of CYP3A4 and CYP3A5 in human lung.
Expression and regulation of cytochrome P-450I genes (CYP1A1 and CYP1A2) in the rat alimentary tract.
Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status.
Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.
Expression of CYP1C1 and CYP1A in Fundulus heteroclitus during PAH-induced carcinogenesis.
Expression of recombinant human cytochrome P450 1A2 in Escherichia coli bacterial mutagenicity tester strain.
Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis.
Expression of two cytochromes P450 involved in carcinogen activation in a human colon cell line.
Expression profile of CYP1A1 and CYP1B1 enzymes in colon and bladder tumors.
Expression profiling of CYP1B1 in oral squamous cell carcinoma: counterintuitive downregulation in tumors.
Expression, induction and regulation of the cytochrome P450 monooxygenase system in the rat glioma C6 cell line.
Fetal mouse Cyp1b1 and transplacental carcinogenesis from maternal exposure to dibenzo(a,l)pyrene.
Fish models for environmental carcinogenesis: the rainbow trout.
From the Cover: PhIP/DSS-Induced Colon Carcinogenesis in CYP1A-Humanized Mice and the Possible Role of Lgr5+ Stem Cells.
Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer.
Functional significance of cytochrome P450 1B1 in endometrial carcinogenesis.
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility.
Genetic analysis of colon tumors induced by a dietary carcinogen PhIP in CYP1A humanized mice: Identification of mutation of ?-catenin/Ctnnb1 as the driver gene for the carcinogenesis.
Genetic and epigenetic regulation of AHR gene expression in MCF-7 breast cancer cells: Role of the proximal promoter GC-rich region.
Genetic damage induced by organic extract of coke oven emissions on human bronchial epithelial cells.
Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse.
Genetic differences in the induction of aryl hydrocarbon hydroxylase and benzo(a)pyrene carcinogenesis in C3H/He and DBA/2 strains of mice.
Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection.
Genetic polymorphism of cytochrome P450 2E1 in the Turkish population.
Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison.
Genetic polymorphisms of CYP2E1 and risk of colorectal adenomas in the Self Defense Forces Health Study.
Genetic polymorphisms of cytochrome P450 1A1 and risk of gallbladder cancer.
Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.
Genistein Induces Cytochrome P450 1B1 Gene Expression and Cell Proliferation in Human Breast Cancer MCF-7 Cells.
Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis.
Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene.
Hemizygous mice for the angiotensin II type 2 receptor gene have attenuated susceptibility to azoxymethane-induced colon tumorigenesis.
HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism.
Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats.
Heterologous expression of rat P450 2E1 in a mammalian cell line: in situ metabolism and cytotoxicity of N-nitrosodimethylamine.
High-throughput screening assays for CYP2B6 metabolism and inhibition using fluorogenic vivid substrates.
Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine.
Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells.
Human CYP1B1 is regulated by estradiol via estrogen receptor.
Human CYP1B1 Leu432Val gene polymorphism: ethnic distribution in African-Americans, Caucasians and Chinese; oestradiol hydroxylase activity; and distribution in prostate cancer cases and controls.
Human CYP2D6 gene polymorphism in Slovene cancer patients and healthy controls.
Human cytochrome P450 2E1 (CYP2E1): from genotype to phenotype.
Human cytochromes P450: evolution and cDNA-directed expression.
Hypomethylation of the XRE -1383 site is associated with the upregulation of CYP1A1 in gastric adenocarcinoma.
Identification of a novel co-transcription of P450/1A1 with telomerase in A549.
Identification of core genes and outcome in gastric cancer using bioinformatics analysis.
Identification of CYP2C9*2 Allele in HepG2 Cell Line.
Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse.
Identification of Energy Metabolism Genes for the Prediction of Survival in Hepatocellular Carcinoma.
Identification of gene and microRNA changes in response to smoking in human airway epithelium by bioinformatics analyses.
Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository.
Identification of molecular target genes and key pathways in hepatocellular carcinoma by bioinformatics analysis.
Identification of Potential Therapeutic Gene Markers in Nasopharyngeal Carcinoma Based on Bioinformatics Analysis.
Identification of structural properties influencing the metabolism of polycyclic aromatic hydrocarbons by cytochrome P450 1A1.
Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody.
Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer.
In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissues.
In vitro transformation of human bronchial epithelial cells by diesel exhaust particles: gene expression profiling and early toxic responses.
Increased expression of the retinoic acid-metabolizing enzyme CYP26A1 during the progression of cervical squamous neoplasia and head and neck cancer.
Independent and Combined Effects of Ethanol Self-administration and Nicotine Treatment on Hepatic CYP2E1 in African Green Monkeys.
Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochrome P450 in female F344 rats.
Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice.
Induction and suppression of cytochrome P450 isoenzymes and generation of oxygen radicals by procymidone in liver, kidney and lung of CD1 mice.
Induction of CYP1A by benzo[k]fluoranthene in human hepatocytes: CYP1A1 or CYP1A2?
Induction of CYP1A1 and CYP2E1 in rat liver by histamine: binding and kinetic studies.
Induction of CYP1A1. The AhR/DRE paradigm: transcription, receptor regulation, and expanding biological roles.
Induction of cytochrome P450 1A1 expression by ginsenoside Rg1 and Rb1 in HepG2 cells.
Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxylated metabolites on cellular apoptosis.
Induction of cytochrome P450 isoforms by carcinogenic aromatic amines and carcinogenic susceptibility of rodent animals.
Induction of cytochrome P4501A1.
Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanism.
Influence of genetic susceptibility on the urinary excretion of 8-hydroxydeoxyguanosine of firefighters.
Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans.
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone mouse lung tumorigenesis by arylalkynes, mechanism-based inactivators of cytochrome P450.
Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids.
Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.
Inhibition of cytochrome P450 1A1 by antisense phosphorothioate oligonucleotide in Hepa lclc7 cells.
Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds.
Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin.
Inhibition of vinyl carbamate-induced hepatotoxicity, mutagenicity, and tumorigenicity by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2- yl)carbamoyl]acetate (YH439).
Inhibitory effect of linoleic acid on transformation of IEC6 intestinal cells by in vitro azoxymethane treatment.
Interactions between detoxifying enzyme polymorphisms and susceptibility to cancer.
Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice.
Involvement of caspase-9 but not caspase-8 in the anti-apoptotic effects of estradiol and 4-OH-Estradiol in MCF-7 human breast cancer cells.
Isolation and sequencing of the cDNA of a novel cytochrome P450 from rat oesophagus.
Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer.
Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer.
iTRAQ-based quantitative proteomics analysis of the hepatoprotective effect of melatonin on ANIT-induced cholestasis in rats.
Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1.
Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice.
Localization of Cytochrome P4502E1 Enzyme in Normal and Cancerous Gastric Mucosa and Association with Its Genetic Polymorphism in Unoperated and Remnant Stomach.
Low synthesis of retinoic acid due to impaired cytochrome P450 1a1 expression in mouse xeroderma pigmentosum fibroblasts.
Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway.
Mechanism Investigation of Rifampicin-Induced Liver Injury Using Comparative Toxicoproteomics in Mice.
Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin.
Mechanisms of alcohol-associated cancers: introduction and summary of the symposium.
Mechanisms of tumor promotion by reactive oxygen species.
Meta-analysis of CYP2E1 polymorphisms in liver carcinogenesis.
Metabolic cytochrome P450 genotypes and assessment of individual susceptibility to lung cancer.
Metabolism of (+)-trans-benzo[a]pyrene-7,8-dihydrodiol by 3-methylcholanthrene-induced rat liver homogenates.
Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human cytochrome P4501B1.
Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1.
Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.
Metabolism of xenobiotics and chemical carcinogenesis.
Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes.
Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.
Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.
Microarray analysis for the identification of specific proteins and functional modules involved in the process of hepatocellular carcinoma originating from cirrhotic liver.
Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review.
Microsomal function in hepatitis B surface antigen healthy carriers: assessment of cytochrome P450 1A2 activity by the 14C-caffeine breath test.
Modulation of benzo[a]pyrene induced immunotoxicity in mice actively immunized with a B[a]P-diphtheria toxoid conjugate.
Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor.
Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options.
Modulation of Estrogen Chemical Carcinogenesis by Botanical Supplements used for Postmenopausal Women's Health.
Modulatory effect of Morus indica against two-stage skin carcinogenesis in Swiss albino mice: possible mechanism by inhibiting aryl hydrocarbon hydroxylase.
Molecular mechanisms, immune cell infiltration, and potential drugs for prostate cancer.
Monooxygenase system in Guerin’s carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Mouse skin tumorigenesis and induction of aryl hydrocarbon hydroxylase by tobacco smoke fractions.
N-Nitrosobenzylmethylamine hydroxylation and coumarin 7-hydroxylation: catalysis by rat esophageal microsomes and cytochrome P450 2A3 and 2A6 enzymes.
Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NF?B and PCNA expression.
Natural anticarcinogens, carcinogens, and changing patterns in cancer: some speculation.
Neonatal phenobarbital imprints overexpression of cytochromes P450 with associated increase in tumorigenesis and reduced life span.
Novel flavonoids as anti-cancer agents: mechanisms of action and promise for their potential application in breast cancer.
Novel non invasive diagnostic strategies in bladder cancer.
Nuclear transcription factor Oct-1 binds to the 5'-upstream region of CYP1A1 and negatively regulates its expression.
Nutritional calcium modulates colonic expression of vitamin D receptor and pregnane X receptor target genes.
Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells.
Oestradiol metabolism and androgen receptor genotypes are associated with right ventricular function.
Oestrogen producing enzymes and mammary carcinogenesis: a review.
Olfactory toxicity of diethyldithiocarbamate (DDTC) and disulfiram and the protective effect of DDTC against the olfactory toxicity of dichlobenil.
Omeprazole, cytochrome P450, and chemical carcinogenesis.
Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.
Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm.
Oral cancer and polymorphism of ethanol metabolising genes.
Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation.
Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin.
Overexpression of CYP2A6 in human colorectal tumors.
Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis.
Oxidative stress mediated idiosyncratic drug toxicity.
p-Nitrophenol and glutathione response in medaka (Oryzias latipes) exposed to MX, a drinking water carcinogen.
Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters.
Perturbation of xenobiotic metabolism in Dreissena polymorpha model exposed in situ to surface water (Lake Trasimene) purified with various disinfectants.
Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis.
Phenobarbital: a non-genotoxic agent which induces the repair of O6-methylguanine from hepatic DNA.
Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis.
Pinocembrin attenuates benzo(a)pyrene-induced CYP1A1 expression through multiple pathways: An in vitro and in vivo study.
Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2.
Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells.
Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo.
Polymorphism in CYP1A1 and CYP2D6 genes: possible association with susceptibility to lung cancer.
Polymorphism of CYP1A1 gene variants rs4646903 and rs1048943 relation to the incidence of cervical cancer in Chhattisgarh.
Polymorphism of human cytochrome P450 enzymes and its clinical impact.
Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol.
Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose.
Polymorphisms of the CYP1B1 gene have higher risk for prostate cancer.
Polymorphisms related to estrogen and xenobiotic metabolism in healthy Turkish women.
Possible mechanism of Sudan III-induced prevention of chemical carcinogenesis in rats.
Possible Mechanisms of Ethanol-Mediated Colorectal Carcinogenesis: The Role of Cytochrome P4502E1, Etheno-DNA Adducts, and the Anti-Apoptotic Protein Mcl-1.
Possible similar role of cytochrome P450 in primordial evolution of species and in chemical carcinogenesis.
Potent inhibition of human cytochrome P450 1B1 by tetramethoxystilbene.
Potential role of CYP1B1 in the development and treatment of metabolic diseases.
Prediction and validation of apoptosis through cytochrome P450 activation by benzo[a]pyrene.
Predictive modes of action of pesticides in uterine adenocarcinoma development in rats.
Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin.
Preferred Binding Orientations of Phenacetin in CYP 1A1 and 1A2 are Associated with Isoform-selective Metabolism.
Presence of a retinoid responsive element in the promoter region of the human cytochrome P4501A1 gene.
Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
Principal xenobiotic-metabolizing enzyme systems in human head and neck squamous cell carcinoma.
Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking.
Prognostic implications of cell division cycle protein 45 expression in hepatocellular carcinoma.
Promoter methylation status in genes related with inflammation, nitrosative stress and xenobiotic metabolism in low-level benzene exposure: Searching for biomarkers of oncogenesis.
Protection against tumorigenesis by 3-methylcholanthrene in mice by beta-naphthoflavone as a function of inducibility of methylcholanthrene metabolism.
Quercetin suppresses cytochrome P450 mediated ROS generation and NF?B activation to inhibit the development of 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinomas.
Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway.
Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate.
Rat oesophageal cytochrome P450 (CYP) monooxygenase system: comparison to the liver and relevance in N-nitrosodiethylamine carcinogenesis.
Re: Hemminki,K., Dickey,C., Karlsson,S., Bell,D., Hsu,Y., Tsai,W.-Y., Mooney,L.A., Savela,K. and Perera,F.P. (1997) Aromatic DNA adducts in foundry workers in relation to exposure, lifestyle and CYP1A1 and glutathione transferase M1 genotype. Carcinogenesis, 18, 345-350.
Re: London,S.J. et al. (1997) Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County. Carcinogenesis, 18, 1203-1214.
Real-time polymerase chain reaction analysis of CYP1B1 gene expression in human liver.
Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism.
Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment.
Regioselective 2-hydroxylation of 17beta-estradiol by rat cytochrome P4501B1.
Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis.
Regulation of cytochrome P450 in cultured human colonic cells.
Renal Transcriptomics Reveals the Carcinogenic Mechanism of Ethyl Carbamate in Musalais.
Respirable coal dust particles modify cytochrome P4501A1 (CYP1A1) expression in rat alveolar cells.
Retinoic acid-metabolizing enzyme cytochrome P450 26A1 promotes skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene.
Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population.
RNA expression of cytochrome P450 in breast cancer patients.
RNA expression of cytochrome p450 in mexican women with breast cancer.
RNA expressions of AHR, ARNT and CYP1B1 are influenced by AHR Arg554Lys polymorphism.
Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
Role of CYP2A5 in the Bioactivation of the Lung Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Mice.
Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo.
Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation.
Role of Hepatic and Intestinal P450 Enzymes in the Metabolic Activation of the Colon Carcinogen Azoxymethane in Mice.
Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
Role of the modulation of CYP1A1 expression and activity in chemoprevention: A mini review.
Safety assessment for non-genotoxic rodent carcinogens: curves, low-dose extrapolations, and mechanisms in carcinogenesis.
Screening and analysis of pathogenic genes during DMBA-induced buccal mucosa carcinogenesis in golden hamsters.
Screening and identification of potential target genes in head and neck cancer using bioinformatics analysis.
Sequential action of phase I and II enzymes cytochrome p450 1B1 and glutathione S-transferase P1 in mammary estrogen metabolism.
Serum increases CYP1A1 induction by 3-methylcholanthrene.
Serum induces a transcriptional activation of CYP1A1 gene in HepG2 independently of the AhR pathway.
Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: A study in human keratinocytes and human hepatoma cells.
Skin and salivary gland carcinogenicity of 7,12-dimethylbenz[a]anthracene is equivalent in the presence or absence of aryl hydrocarbon receptor.
Smoking and susceptibility to thyroid cancer: an inverse association with CYP1A1 allelic variants.
Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity.
Steroid hormone synthesis by the ovarian stroma surrounding epithelial ovarian tumors: a potential mechanism in ovarian tumorigenesis.
Structure-activity relationship and in vitro inhibition of human cytochrome CYP2A6 and CYP2A13 by flavonoids.
Structure-activity relationships in polycyclic aromatic hydrocarbons: induction of microsomal aryl hydrocarbon hydroxylase and its possible importance in chemical carcinogenesis.
Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands.
Suppression of cytochrome P450 4B1: An early event in adrenocortical tumorigenesis.
T-2 toxin upregulates the expression of human cytochrome P450 1A1 (CYP1A1) by enhancing NRF1 and Sp1 interaction.
Target organ-specific inactivation of drug metabolizing enzymes in kidney of hamsters treated with estradiol.
Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis.
The ?-3 epoxide of eicosapentaenoic acid inhibits endothelial cell proliferation by p38 MAP kinase activation and cyclin D1/CDK4 down-regulation.
The antitumour activity of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole in human gastric cancer models is mediated by AhR signalling.
The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis.
The characteristics of HPV integration in cervical intraepithelial cells.
The clinical value and potential molecular mechanism of the downregulation of MAOA in hepatocellular carcinoma tissues.
The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.
The cytochromes P450 and mechanisms of chemical carcinogenesis.
The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.
The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells.
The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis.
The effect of tobacco on lung cancer risk depends on CYP2D6 activity.
The effects of anti-inflammatory agents on skin tumor initiation and aryl hydrocarbon hydroxylase.
The enhancing effect of ethanol on the mutagenic activation of N-nitrosomethylbenzylamine by cytochrome P450 2A in the rat oesophagus.
The formation of 3-methylcholanthrene-initiated lung tumors correlates with induction of cytochrome P450IA1 by the carcinogen in fetal but not adult mice.
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
The mechanism of Psoralen and Isopsoralen hepatotoxicity as revealed by hepatic gene expression profiling in SD rats.
The model Ah-receptor agonist beta-naphthoflavone inhibits aflatoxin B1-DNA binding in vivo in rainbow trout at dietary levels that do not induce CYP1A enzymes.
The Multiple Biological Targets of Hops and Bioactive Compounds.
The role of aryl hydrocarbon hydroxylase in 7,12-dimethylbenz(a)anthracene skin tumorigenesis: on the mechanism of 7,8-benzoflavone inhibition of tumorigenesis.
The role of CYP1A1 Msp1 gene polymorphisms on lung cancer development in Turkey.
The Role of Cytochrome P450 2E1 in Ethanol-Mediated Carcinogenesis.
The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis.
The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts.
The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis.
Time-dependent acetylsalicylic acid effects on liver CYP1A and antioxidant enzymes in a rat model of 7,12-dimethylbenzanthracene (DMBA)-induced mammary carcinogenesis.
Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene.
Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene.
Tobacco smoke induces CYP1B1 in the aerodigestive tract.
Tolfenamic acid suppresses cytochrome P450 2E1 expression in mouse liver.
Transcriptome signature of liver tissue with divergent mutton odour and flavour using RNA deep sequencing.
Transplacental lung carcinogenesis: a pharmacogenetic mouse model for the modulatory role of cytochrome P450 1A1 on lung cancer initiation.
Unique cytochromes P450 in human brain: implication in disease pathogenesis.
Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway.
Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1.
Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse.
Using a combination of cytochrome P450 1B1 and beta-catenin for early diagnosis and prevention of colorectal cancer.
Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene.
UXT antisense RNA 1 sever as a novel prognostic long non-coding RNA in early stage pancreatic ductal adenocarcinoma patients after receiving pancreaticoduodenectomy.
Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer.
Vitamin K as a regulator of benzo(a)pyrene metabolism, mutagenesis, and carcinogenesis. Studies with rat microsomes and tumorigenesis in mice.
Whole transcriptome analysis of chemically-induced hepatocellular carcinoma using RNA sequencing analysis.
Xenobiotics and xenoestrogens in fish: modulation of cytochrome P450 and carcinogenesis.
[A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer]
[A role of aryl hydrocarbon hydroxylase inducibility in susceptibility to lung carcinogenesis]
[Aryl hydrocarbon hydroxylase activity in the livers of mice of genetically different strains during chemical carcinogenesis]
[Association of cytochrome P-450 1A1 (CYP1A1) gene polymorphism to smoking status and hematologic findings]
[Bioactivation of xenobiotics by cytochrome P-448 and its role in the process of carcinogenesis]
[Bioinformatics analysis of key genes and prognosis-related genes during the onset of hepatocellular carcinoma].
[Chemical carcinogenesis and cytochrome P450: carcinogenic aromatic amine-induced P450 and hepatocarcinogenic susceptibility to the aromatic amine in the rodent]
[Cloning and sequence analysis of human embryonic nasopharyngeal epithelial CYP2E1 cDNA]
[Construction of thr461 --> Asn461 and Ile462 --> Val462 mutation vector of P4501A1 gene]
[Effect of low doses of x-ray irradiation on the liver detoxication system in rats with transplanted Guerin's carcinoma].
[Effect of xenobiotics on microRNA expression in rat liver].
[Effects of CYP1A1 and GSTM1 gene polymorphisms and BPDE-DNA adducts on lung cancer].
[Expression of human cytochrome P450 2E1 gene in embryonic nasopharynx, nasopharyngeal cancer cell lines and tissue]
[Genetic polymorphism of cytochrome P4501A1 and susceptibility to laryngeal carcinoma]
[Genetic polymorphisms of cytochrome P450 2E1 and glutathione S-transferase P1 and susceptibility to esophageal cancer]
[Importance of aryl hydrocarbon hydroxylase in laryngeal oncogenesis. Preliminary data]
[P450 and carcinogenesis]
[Regulation of human CYP1B1 and its role in carcinogenesis and estrogen homeostasis]
[Stable expression of human cytochrome P450 2E1 cDNA in nasopharyngeal cancer cell line CNE-2]
[The role of Cytochrom P4502E1 in Alcoholic Liver Disease and alcohol mediated carcinogenesis].
Carcinoma
11Beta-hydroxysteroid dehydrogenase 1 expression in squamous cell carcinomas of the head and neck.
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma.
?-Catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells.
A case of renin-producing adrenocortical cancer.
A comparison between lung carcinoma and a subcutaneous malignant tumor induced in rats by a 3,4-benzopyrene injection.
A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years.
A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population.
A regulatory variant in CYP2E1 affects the risk of lung squamous cell carcinoma.
A significantly joint effect between arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma.
ACTH-receptor expression, regulation and role in adrenocortial tumor formation.
Activation and overexpression of the aryl hydrocarbon receptor contribute to cutaneous squamous cell carcinomas: an immunohistochemical study.
Activation of Fas receptor modulates cytochrome P450 3A4 expression in human colon carcinoma cells.
Allelic variations in CYP2D6 gene and susceptibility to cervical cancer.
Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice.
Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions.
Altered patterns of cutaneous xenobiotic metabolism in UVB-induced squamous cell carcinoma in SKH-1 hairless mice.
Altered regulation of the cytochrome P4501A1 gene: novel inducer-independent gene expression in pulmonary carcinoma cell lines.
Analysis of RNA from brush cytology detects changes in B2M, CYP1B1 and KRT17 levels with OSCC in tobacco users.
Analysis of the role of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 gene in the risk of squamous cell carcinoma.
Antimigraine Drug Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor That Induces CYP1A1 in Hepatic and Intestinal Cells.
Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.
Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo.
Arsenite pretreatment attenuates benzo[a]pyrene cytotoxicity in a human lung adenocarcinoma cell line by decreasing cyclooxygenase-2 levels.
Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls.
Aryl hydrocarbon hydroxylase inducibility and carcinoma of oral cavity.
Aryl hydrocarbon hydroxylase inducibility and carcinoma of renal pelvis and ureter.
Aryl hydrocarbon hydroxylase inducibility in laryngeal carcinoma.
Aryl hydrocarbon hydroxylase induction levels in patients with malignant tumors associated with smoking.
Association and treatment response to capecitabine-based chemoradiotherapy with CYP2C9 polymorphism in head and neck cancer.
Association between CYP1A1 Ile462Val Polymorphism and Oral Squamous Cell Carcinoma Susceptibility: Evidence from 13 Investigations.
Association between cytochrome P450 1A1 (CYP1A1) gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis.
Association between GSTM1 and CYP1A1 polymorphisms and survival in oral cancer patients.
Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high-incidence area of northern China.
Association of Androgen Receptor, Prostate-Specific Antigen, and CYP19 Gene Polymorphisms with Prostate Carcinoma and Benign Prostatic Hyperplasia in a North Indian Population.
Association of aryl hydrocarbon receptor and cytochrome P4501B1 expressions in human non-small cell lung cancers.
Association of cigarette smoking and CYP1A1 polymorphisms with adenocarcinoma of the lung by grades of differentiation.
Association of combined CYP2E1 gene polymorphism with the risk for esophageal squamous cell carcinoma in Huai'an population, China.
Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma.
Association of cytochrome P450 1B1 haplotypes with head and neck cancer risk.
Association of cytochrome P450 2C9 polymorphism with locally advanced head and neck squamous cell carcinoma and response to concurrent cisplatin-based radical chemoradiation.
Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus.
Association of Genetic Polymorphisms of Aldehyde Dehydrogenase-2 and Cytochrome P450 2E1-RsaI and Alcohol Consumption with Oral Squamous Cell Carcinoma.
Association of Genetic Variants of CYP2C19 and CYP2D6 with Esophageal Squamous Cell Carcinoma Risk in Northern India, Kashmir.
Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci.
Association of polymorphism in cytochrome P450 2C9 with susceptibility to head and neck cancer and treatment outcome.
Association of poor metabolizers of cytochrome P450 2C19 with head and neck cancer and poor treatment response.
Association of Smoking and XPG, CYP1A1, OGG1, ERCC5, ERCC1, MMP2, and MMP9 Gene Polymorphisms with the early detection and occurrence of Laryngeal Squamous Carcinoma.
Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses.
Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens.
BTEX in vitro exposure tool using human lung cells: Trips and gains.
Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models.
C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression.
Carcinoma of the oral cavity in relation to aryl hydrocarbon hydroxylase inducibility, smoking and dental status.
Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes.
Changes in expression of drug-metabolizing enzymes by single-walled carbon nanotubes in human respiratory tract cells.
Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties.
Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line.
Characterization of the aryl hydrocarbon receptor and aryl hydrocarbon responsiveness in human ovarian carcinoma cell lines.
Chromosomal region 15q21.1 is a frequent target of allelic imbalance in advanced breast carcinomas.
Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells.
Combination of polymorphisms from genes related to estrogen metabolism and risk of prostate cancers: the hidden face of estrogens.
Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1A1, and CYP2E1: relation to the incidence rate of cervical carcinoma.
Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects.
Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer.
Comparison of cytochrome P450- and peroxidase-dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites.
Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility.
Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer.
Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis.
CYP1 and AhR expression in 7,12-dimethylbenz[a]anthracene-induced mammary carcinoma of rats prenatally exposed to 3,3',4,4',5-pentachlorobiphenyl.
CYP1A1 activity in renal cell carcinoma and in adjacent normal renal tissue.
CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population.
CYP1A1 and CYP2E1 genotypes and risk of esophageal squamous cell carcinoma in a high-incidence region, Kashmir.
CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil.
CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses.
CYP1A1 and GSTP1 polymorphisms in an oral cancer case-control study.
CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx.
CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm.
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.
CYP1A1 MspI Polymorphism and Cervical Carcinoma Risk in the Multi-Ethnic Population of Malaysia: a Case-Control Study.
CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta-analysis.
CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma.
CYP1A1, CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus.
CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma.
CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China.
CYP1a1, HSP70, P53, and c-fos expression in human liver carcinoma cells (HepG2) exposed to pentachlorophenol.
CYP1A2 164 A-->C polymorphism, cigarette smoking, consumption of well-done red meat and risk of developing colorectal adenomas and carcinomas.
CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population.
CYP1B1 expression in ovarian cancer in the laying hen Gallusdomesticus.
CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma.
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
CYP2C9 inhibits the invasion and migration of esophageal squamous cell carcinoma via downregulation of HDAC.
CYP2D6 gene polymorphism in caucasian smokers: lung cancer susceptibility and phenotype-genotype relationships.
CYP2E1 G1532C, NQO1 Pro187Ser, and CYP1B1 Val432Leu polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck.
CYP3A5 and ABCB1 polymorphisms as predictors for sunitinib outcome in metastatic renal cell carcinoma.
Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer.
Cytochrome P450 1A1 expression and activity in Caco-2 cells: modulation by apple juice extract and certain apple polyphenols.
Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls.
Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma.
Cytochrome P450 1B1 polymorphisms and risk of renal cell carcinoma in men.
Cytochrome P450 2E1 and head and neck cancer: Interaction with genetic and environmental risk factors.
Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.
Cytochrome P450 CYP1B1 activity in renal cell carcinoma.
Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract.
Cytochrome P450 expression in oesophageal cancer.
Cytochrome P450 isoenzyme mRNA expression pattern in human urinary bladder malignancies and normal urothelium.
Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma.
Deregulation of signaling pathways controlling cell survival and proliferation in cancer cells alters induction of cytochrome P450 family 1 enzymes.
Design of a VLP-nanovehicle for CYP450 enzymatic activity delivery.
Dietary ellagic acid inhibits the enzymatic activity of CYP1A1 without altering hepatic concentrations of CYP1A1 or CYP1A1 mRNA.
Differential induction of CYP1A1 and CYP1B1 by benzo[a]pyrene in oral squamous cell carcinoma cell lines and by tobacco smoking in oral mucosa.
Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis.
Diminished CYP2E1 expression and formation of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene epoxide, in murine lung tumors.
Does CYP2E1 RsaI/PstI polymorphism confer head and neck carcinoma susceptibility?: A meta-analysis based on 43 studies.
Downregulation of the cytochrome P450 4B1 protein confers a poor prognostic factor in patients with urothelial carcinomas of upper urinary tracts and urinary bladder.
Dual-color fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cells.
Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer.
Effect of the CYP3A5 and ABCB1 genotype on exposure, clinical response and manifestation of toxicities from sunitinib in Asian patients.
Effects of herbal medicinal products and food supplements on induction of CYP1A2, CYP3A4 and MDR1 in the human colon carcinoma cell line LS180.
Epigenetic and genetic dissections of UV-induced global gene dysregulation in skin cells through multi-omics analyses.
Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126).
Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9).
Evaluation of CYP1B1 Expression, Oxidative Stress and Phase 2 Detoxification Enzyme Status in Oral Squamous Cell Carcinoma Patients.
Expression alterations of cytochromes P4501A1, 2E1, and 3A, and their receptors AhR and PXR caused by 1-octyl-3-methylimidazolium chloride in mouse mammary carcinoma cells.
Expression and activity of vitamin D-metabolizing cytochrome P450s (CYP1alpha and CYP24) in human nonsmall cell lung carcinomas.
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium.
Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.
Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells.
Expression of CYP1C1 and CYP1A in Fundulus heteroclitus during PAH-induced carcinogenesis.
Expression of cytochrome P450s and glutathione S-transferases in human esophagus with squamous-cell carcinomas.
Expression of enzyme associated with steroid hormone synthesis and local production of steroid hormone in endometrial carcinoma cells.
Expression of Genes for Methylxanthine Pathway-Associated Enzymes Accompanied by Sex Steroid Receptor Status Impacts Breast Carcinoma Progression.
Expression profiling of CYP1B1 in oral squamous cell carcinoma: counterintuitive downregulation in tumors.
Expressions of cytochrome P450, UDP-glucuronosyltranferase, and transporter genes in monolayer carcinoma cells change in subcutaneous tumors grown as xenografts in immunodeficient nude mice.
Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures.
Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population.
Gene expression profiling of cultured human bronchial epithelial and lung carcinoma cells.
Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus.
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.
Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use.
Genetic polymorphism of xenobiotic metabolising enzymes in Slovenian lung cancer patients.
Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review).
Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population.
Genetic polymorphisms in Cytochrome P4501B1 and susceptibility to Head and Neck Cancer.
Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.
Genetic polymorphisms in the Cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx.
Genetic Polymorphisms of ADH1C and CYP2E1 and Risk of Oral Squamous Cell Carcinoma.
Genetic polymorphisms of cytochrome p450 2E1, glutathione S-transferase M1 and T1, and susceptibility to gastric carcinoma in Taiwan.
Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan.
Genetic polymorphisms of estrogen receptor alpha, CYP19, catechol-O-methyltransferase are associated with familial prostate carcinoma risk in a Japanese population.
Genetic polymorphisms of metabolic enzymes-CYP1A1, CYP2D6, GSTM1, and GSTT1, and gastric carcinoma susceptibility.
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
Genetic variants in CYP and GST genes, smoking and risk for head and neck cancers: a gene-environment interaction hospital-based case-control study among Canadian Caucasians.
Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes.
Genotyping of the CYP1A1 and GSTM1 genes in esophageal carcinoma patients with special reference to smoking.
Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma.
Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions.
GST M1 and CYP1A1 gene polymorphism and daily fruit consumption in Turkish patients with non-small cell lung carcinomas.
GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels.
GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.
GSTT1, GSTM1, and CYP1B1 gene polymorphisms and susceptibility to sporadic renal cell cancer.
Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.
Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.
hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.
Identification and characterization of genes associated with human hepatocellular carcinogenesis.
Identification of a novel co-transcription of P450/1A1 with telomerase in A549.
Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.
Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.
Immunohistochemical detection of CYP2E1 and 2-S-glutathionyl acetate in murine lung tumors: diminished formation of reactive intermediates of 1,1-dichloroethylene.
Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis.
Immunohistochemical localization of cytochrome P450 2E1 in human pulmonary carcinoma and normal bronchial tissue.
Immunohistochemical localization of cytochrome P450 3A in human pulmonary carcinomas and normal bronchial tissue.
Impact of body size on first-line Helicobacter pylori eradication success using vonoprazan and amoxicillin dual therapy.
Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China.
Important role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistance.
In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles.
Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis.
Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.
Induction of aryl hydrocarbon hydroxylase activity and pulmonary carcinoma.
Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells by 6-nitrochrysene.
Induction of cytochromes P450 1A1 and 1B1 in human lung adenocarcinoma CL5 cells by frying-meat emission particulate.
Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population.
Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome.
Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol.
Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists.
Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[a,l]pyrene in cells in culture.
Intake of flavonoids and lung cancer.
Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer.
Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response.
Involvement of CYP1B1 in interferon ?-induced alterations of epithelial barrier integrity.
Isolation and spontaneous transformation of cloned lines of hamster tracheal epithelial cells.
Lack of association among polymorphic xenobiotic-metabolizing enzyme genotypes and the occurrence and progression of oral carcinoma in a Brazilian population.
Letter: Aryl hydrocarbon hydroxylase inducibility and laryngeal carcinomas.
Leu432Val Polymorphism of CYP1B1 is Not Associated with Squamous Cell Carcinoma of Esophagus--a Case-Control Study from Kashmir, India.
Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma.
Meta-analyses of the effect of CYP1A1 and CYP2D6 polymorphisms on the risk of head and neck squamous cell carcinoma.
Meta-analysis of association studies of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese.
Meta-analysis of the CYP1A2 -163C>A Polymorphism and Lung Cancer Risk.
Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue.
miR?543 acts as a novel oncogene in oral squamous cell carcinoma by targeting CYP3A5.
Monooxygenase system in Guerin’s carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual.
Overexpression of CYP2A6 in human colorectal tumors.
Overexpression of cytochrome P450 1B1 in advanced non-small cell lung cancer: a potential therapeutic target.
p53 gene mutations, and CYP1A1 and GSTM1 genotypes in pulmonary squamous cell carcinomas.
p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines.
p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use.
Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.
Polimorfismos en los genes de la enzima alcohol deshidrogenasa (ADH1) y la citocromo P450 2E1 (CYP2E1) en pacientes con cirrosis y carcinoma hepatocelular.
Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes.
Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma.
Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men.
Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome.
Polymorphism in cytochrome P4501A1 is significantly associated with head and neck cancer risk.
Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients.
Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India.
Polymorphisms in drug-metabolizing enzymes and risk to head and neck cancer: evidence for gene-gene and gene-environment interaction.
Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe.
Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses.
Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer.
Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk.
Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population.
Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose.
Polymorphisms of the CYP1A1 and GSTM1 genes in relation to individual susceptibility to lung carcinoma in Chinese population.
Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols.
Prenatal 3,3',4,4',5-pentachlorobiphenyl exposure modulates induction of rat hepatic CYP 1A1, 1B1, and AhR by 7,12-dimethylbenz[a]anthracene.
Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype.
Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells.
Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways.
Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinoma.
PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides.
Quantitative assessment of the influence of CYP1B1 polymorphisms and head and neck squamous cell carcinoma risk.
Quercetin suppresses cytochrome P450 mediated ROS generation and NF?B activation to inhibit the development of 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinomas.
Quinazoline derivatives as selective CYP1B1 inhibitors.
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Relevance of CYP3A5 Expression on the Clinical Outcome of Patients With Renal Cell Carcinoma.
Renal cell carcinoma: etiology, incidence and epidemiology.
Resistance of murine lung tumors to xenobiotic-induced cytotoxicity.
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Risk of renal cell carcinoma and polymorphism in phase I xenobiotic metabolizing CYP1A1 and CYP2D6 enzymes.
Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population.
Role of c-Myc in nitric oxide-mediated suppression of cytochrome P450 3A4.
Role of the N-acetyltransferase 2 detoxification system in thyroid cancer susceptibility.
Screening and analysis of pathogenic genes during DMBA-induced buccal mucosa carcinogenesis in golden hamsters.
Selective Antitumor Effect of Shikonin Derived DMAKO-20 on Melanoma through CYP1B1.
Sensitivity of renal cell carcinoma to aminoflavone: role of CYP1A1.
Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.
Study the polymorphism of CYP3A5 and CYP3A4 loci in Iranian population with laryngeal squamous cell carcinoma.
Superoxide dismutase and cytochrome P450 isoenzymes might be associated with higher risk of renal cell carcinoma in male patients.
Suppression of aryl hydrocarbon hydroxylase activity in human primary lung carcinoma x mouse hepatoma somatic cell hybrids.
Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator.
Synergistic association of CYP1A1 polymorphisms with increased susceptibility to squamous cell lung cancer in north Indian smokers.
Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue.
Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential.
Taxifolin Inhibits 7,12-Dimethylbenz(a)anthracene-induced Breast Carcinogenesis by Regulating AhR/CYP1A1 Signaling Pathway.
The frequency of cytochrome P450 2E1 polymorphisms in Black South Africans.
The ovarian carcinoma risk with the polymorphisms of CYP1B1 come from the positive selection.
The steroid hormone dehydroepiandrosterone inhibits CYP1A1 expression in vitro by a post-transcriptional mechanism.
Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population.
Transcriptomic analysis of an in vitro murine model of ovarian carcinoma: Functional similarity to the human disease and identification of prospective tumoral markers and targets.
Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction.
Using a combination of cytochrome P450 1B1 and beta-catenin for early diagnosis and prevention of colorectal cancer.
Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines.
Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma.
Xenobiotic metabolising enzyme expression in colonic neoplasia.
[Cytochrome P450IA1 and the genetic susceptibility to esophageal carcinoma]
[Effect of low doses of x-ray irradiation on the liver detoxication system in rats with transplanted Guerin's carcinoma].
[First results on the influence of polymorphisms at glutathione S-transferase, cytochrome P450, and tumor necrosis factor gene loci on the development of multiple head and neck cancer]
[Genetic polymorphism of cytochrome P4501A1 and susceptibility to laryngeal carcinoma]
[Influence of glutathione s-transferase and cytochrome p450 polymorphisms on prognosis of head and neck cancer]
[Initial results of glutathione-S-transferase GSTM1 and GSTT1 genotypes and genetic predisposition for laryngeal carcinoma]
[Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]
[Role of metabolic polymorphisms in lung carcinogenesis]
[Smoking and induction of the enzyme aryl hydrocarbon hydroxylase in patients with laryngeal carcinomas and precancerous conditions]
[Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China.]
[Study on the Difference of Gene Expression between Central and Peripheral Lung Squamous Cell Carcinoma Based on TCGA Database].
[The induction of Guerin's carcinoma cytochrome p450 hydroxylase activity by retinoids].
Carcinoma in Situ
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium.
Carcinoma, Basal Cell
Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci.
Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome.
Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual.
Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma.
Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype.
Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction.
Carcinoma, Bronchogenic
Aryl hydrocarbon hydroxylase and bronchogenic carcinomas associated with smoking.
Aryl hydrocarbon hydroxylase in bronchogenic carcinoma.
Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.
Debrisoquin oxidation genotype and susceptibility to lung cancer.
Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.
Is environmental carcinogenesis modulated by host polymorphism?
Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells.
Phase II study of 4-ipomeanol, a naturally occurring alkylating furan, in patients with advanced hepatocellular carcinoma.
The effect of cigarette smoke on aryl hydrocarbon hydroxylase activity and cytochrome P450 content in rat liver and lung microsomes.
Carcinoma, Ductal
7-ethoxyresorufin O-deethylase (EROD) activity is not capable of reflecting the overall malignant potential of breast cancer tissue.
Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties.
CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma.
Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues.
Carcinoma, Ductal, Breast
GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.
Carcinoma, Embryonal
Expression of the mouse P(1)450 gene during differentiation without foreign chemical stimulation.
Carcinoma, Endometrioid
Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma.
Carcinoma, Hepatocellular
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
2,3,7,8-Tetrachlorodibenzo-p-dioxin receptors regulate transcription of the cytochrome P1-450 gene.
2-(4'-chlorophenyl)benzothiazole is a potent inducer of cytochrome P450IA1 in a human and a mouse cell line. Anomalous correlation between protein and mRNA induction.
2-Phenylphenanthridinone and related compounds: aryl hydrocarbon receptor agonists and suicide inactivators of P4501A1.
A CAR-responsive enhancer element locating approximately 31 kb upstream in the 5'-flanking region of rat cytochrome P450 (CYP) 3A1 gene.
A fish hepatoma cell line (PLHC-1) as a tool to study cytotoxicity and CYP1A induction properties of cellulose and wood chip extracts.
A genetic analysis of processes regulating cytochrome P4501A1 expression.
A Link between cholesterol levels and phenobarbital induction of cytochromes P450.
A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma.
A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides.
A silent mutation (2939G>A, exon 6; CYP2D6*59) leading to impaired expression and function of CYP2D6.
A soluble NH(2)-terminally truncated catalytically active form of rat cytochrome P450 2E1 targeted to liver mitochondria(1).
A technical mixture of 2,2',4,4'-tetrabromo diphenyl ether (BDE47) and brominated furans triggers aryl hydrocarbon receptor (AhR) mediated gene expression and toxicity.
Aberrant CYP1A1 induction: discrepancy of CYP1A1 mRNA and aryl hydrocarbon hydroxylase activity in mutant cells of mouse hepatoma line, Hepa-1.
Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1.
Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2).
Ah receptor mediating induction of aryl hydrocarbon hydroxylase: detection in human lung by binding of 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.
AhR regulates the expression of human cytochrome P450 1A1 (CYP1A1) by recruiting Sp1.
Alcohol-and-HIV-Induced Lysosomal Dysfunction Regulates Extracellular Vesicles Secretion in Vitro and in Liver-Humanized Mice.
All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells.
Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers.
alpha-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation.
AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.
An "in vitro" approach to water pollution monitoring.
An autoregulatory loop controlling CYP1A1 gene expression: role of H(2)O(2) and NFI.
Analysis of Ah gene locus by somatic cell hybridization: expression of Ah regulatory gene product for 2,3,7,8,-tetrachlorodibenzo-p-dioxin in mouse L-cell x mouse hepatoma cell hybrids.
Antagonistic and agonistic effects of indigoids on the transformation of an aryl hydrocarbon receptor.
Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats.
Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid.
Antigenic stimulation with cytochrome P450 2J expressed in mouse hepatocellular carcinoma cells regulates host anti-tumour immunity.
Antigenotoxic effect of Xanthohumol in rat liver slices.
Application of Statistical Experimental Design and Multivariate Data Analysis for Evaluation of Mixtures using Cytochrome P4501A Induction.
Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining "2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents": pyrolyzed brominated flame retardants.
Arecoline inhibits the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1A1 activation in human hepatoma cells.
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity.
Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatoma cells.
Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver.
Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Effects of various metabolic inhibitors on the enzyme activity in hepatoma cells.
Aryl hydrocarbon receptor activation and cytochrome P450 1A induction by the mitogen-activated protein kinase inhibitor U0126 in hepatocytes.
Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells.
Assessment of Gold Nanoparticles-Inhibited Cytochrome P450 3A4 Activity and Molecular Mechanisms Underlying Its Cellular Toxicity in Human Hepatocellular Carcinoma Cell Line C3A.
Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis.
Association of CYP1A2 genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a high-risk region of China.
Astaxanthin rich crude extract of Haematococcus pluvialis induces cytochrome P450 1A1 mRNA by activating aryl hydrocarbon receptor in rat hepatoma H4IIE cells
Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine.
Basis for the loss of aryl hydrocarbon receptor gene expression in clones of a mouse hepatoma cell line.
Benzo[a]pyrene-dependent activation of transcription factors NF-kappaB and AP-1 related to tumor promotion in hepatoma cell cultures.
Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs).
Binding of polynuclear aromatic hydrocarbons to the rat 4S cytosolic binding protein: structure-activity relationships.
Bioassay for determining 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TEs) in human hepatoma Hepg2 cells.
Biochemical screening of highly toxic aromatic contaminants in river sediment and comparison of sensitivity of biological model systems.
Biochemistry and enzyme induction in MC-29 virus-induced transplantable avian hepatoma.
Biomonitoring of polycyclic aromatic hydrocarbons on hepatocellular carcinoma cell line.
Biotransformation of 17 beta-hydroxy-11 beta-(4-dimethylaminophenyl)17 alpha-1-propynyl-estra-4,9-dien-3-one (RU486) in rat hepatoma variants.
Black tea polyphenols, theaflavins, prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P450 1A1 in cell cultures.
Blockage of multidrug resistance-associated proteins potentiates the inhibitory effects of arsenic trioxide on CYP1A1 induction by polycyclic aromatic hydrocarbons.
Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells.
Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line.
Can hepatoma cell lines be redifferentiated to be used in drug metabolism studies?
Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells.
CCAAT/enhancer-binding protein ? activation by capsaicin contributes to the regulation of CYP1A1 expression, mediated by the aryl hydrocarbon receptor.
CCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: application to the development of a metabolically competent human hepatic cell model.
Changes of CYP1A1, GST, and ALDH3 enzymes in hepatoma cell lines undergoing enhanced lipid peroxidation.
Characterization of CYP1A1 and CYP1A3 gene expression in rainbow trout (Oncorhynchus mykiss).
Characterization of cytochrome P450 2E1 induction in a rat hepatoma FGC-4 cell model by ethanol.
Characterization of hamster CYP1A1 gene: inducible expression and negative regulation.
Characterization of human CYP1A1/1A2 induction by DNA microarray and alpha-naphthoflavone.
Characterization of the environmental quality of sediments from two estuarine systems based on different in-vitro bioassays.
Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin.
Cis-Nerolidol Induces Endoplasmic Reticulum Stress and Cell Death in Human Hepatocellular Carcinoma Cells through Extensive CYP2C19 and CYP1A2 Oxidation.
Combined chemical and toxicological long-term monitoring for AhR agonists with SPMD-based virtual organisms in drinking water Danjiangkou Reservoir, China.
Commiphora myrrha (Nees) Engl. resin extracts induce phase-I cytochrome P450 2C8, 2C9, 2C19, and 3A4 isoenzyme expressions in human hepatocellular carcinoma (HepG2) cells.
Common genetic variations of the cytochrome P450 1A1 gene and risk of hepatocellular carcinoma in a Chinese population.
Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression.
Comparison of expression of aldehyde dehydrogenase 3 and CYP1A1 in dominant and recessive aryl hydrocarbon hydroxylase-deficient mutant mouse hepatoma cells.
Comparison of mouse and chick embryo liver and hepatoma cell lines as model systems used for enzymological estimation of toxicity potentials of organic pollutants.
Comparison of Paeoniflorin and Albiflorin on Human CYP3A4 and CYP2D6.
Comparison of TCDD and PCB CYP1A induction sensitivities in fresh hepatocytes from human donors, sprague-dawley rats, and rhesus monkeys and HepG2 cells.
Competitive binding to the cytosolic 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor. Effects of structure on the affinities of substituted halogenated biphenyls--a QSAR analysis.
Constitutive activation of the aromatic hydrocarbon receptor.
Control of cytochrome P1-450 gene expression by dioxin.
Cooperative regulation of CYP3A5 gene transcription by NF-Y and Sp family members.
Correlation of antimutagenic activity and suppression of CYP1A with the lipophilicity of alkyl gallates and other phenolic compounds.
Correlation of PPM1A Downregulation with CYP3A4 Repression in the Tumor Liver Tissue of Hepatocellular Carcinoma Patients.
CpG methylation of the mouse CYP1A2 promoter.
CYP1A induction potential and the concentration of priority pollutants in marine sediment samples--in vitro evaluation using the PLHC-1 fish hepatoma cell line.
CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures.
CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines.
CYP1A1-inducing potency in H4IIE cells and chemical composition of technical mixtures of polychlorinated biphenyls.
CYP1A2 suppresses hepatocellular carcinoma through antagonizing HGF/MET signaling.
CYP2E1 overexpression up-regulates both non-specific delta-aminolevulinate synthase and heme oxygenase-1 in the human hepatoma cell line HLE/2E1.
CYP2E1 PstI/RsaI polymorphism and interaction with alcohol consumption in hepatocellular carcinoma susceptibility: evidence from 1,661 cases and 2,317 controls.
CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling.
CYP3A5 is unlikely to mediate anticancer drug resistance in hepatocellular carcinoma.
CYP3A5*1 is an inhibitory factor for lung cancer in Taiwanese.
CYP450 enzyme-specific enantioselective species-specific response for metalaxyl in in vitro hepatic cells.
Cyprodinil as an activator of aryl hydrocarbon receptor.
Cytochrome P-448 induction restores the propagation of .O2--induced lipid peroxidation in hepatoma microsomes.
Cytochrome P450 (CYP1A) induction and DNA adducts in a rat hepatoma cell line (Fao), exposed to environmentally relevant concentrations of organic compounds, singly and in combinations.
Cytochrome P450 1A1 (CYP1A1) Catalyzes Lipid Peroxidation of Oleic Acid-Induced HepG2 Cells.
Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor kappaB.
Cytochrome P450 1A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers.
Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells.
Cytochrome P450 1A2 Metabolizes 17?-Estradiol to Suppress Hepatocellular Carcinoma.
Cytochrome P450 1A2 overcomes nuclear factor kappa B-mediated sorafenib resistance in hepatocellular carcinoma.
Cytochrome P450 2A6 is associated with macrophage polarization and is a potential biomarker for hepatocellular carcinoma.
Cytochrome P450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoma.
Cytochrome P450 2E1 gene polymorphism and alcohol drinking on the risk of hepatocellular carcinoma: a meta-analysis.
Cytochrome P450 2E1 increases the sensitivity of hepatoma cells to vitamin K2.
Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis.
Cytochrome P450 and liver diseases.
Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells.
Cytochrome P450 family members are associated with fast-growing hepatocellular carcinoma and patient survival: An integrated analysis of gene expression profiles.
Cytochrome P450 induction by nitrated polycyclic aromatic hydrocarbons, azaarenes, and binary mixtures in fish hepatoma cell line PLHC-1.
Cytochrome P450 isozyme distribution in normal and tumor-bearing hepatic tissue from rainbow trout (Salmo gairdneri).
Cytochrome P4501A1 promotes G1 phase cell cycle progression by controlling aryl hydrocarbon receptor activity.
Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma.
Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A.
Cytokine-mediated down-regulation of CYP1A1 in Hepa1 cells.
Cytokine-mediated suppression of cytochrome P450 1A1 in Hepa-1c1c7 cells by pokeweed mitogen.
Cytotoxic effects of benzbromarone and its 1'-hydroxy metabolite in human hepatocarcinoma FLC4 cells cultured on micro-space cell culture plates.
Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells.
Cytotoxicity of hexahelicene and its effect on the aryl hydrocarbon receptor pathway.
Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma.
Determination of interleukin-4-responsive region in the human cytochrome P450 2E1 gene promoter.
Development and application of test methods for the detection of dietary constituents which protect against heterocyclic aromatic amines.
Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review.
Dibenzoylmethane modulates aryl hydrocarbon receptor function and expression of cytochromes P50 1A1, 1A2, and 1B1.
Differences in induction by xenobiotics in murine tissues and the Hepa1c1c7 cell line of mRNAs encoding glutathione transferase, quinone reductase, and CYP1A P450s.
Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells.
Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5, CYP3A7 and CYP3A43.
Differential effect of arecoline on the endogenous dioxin-responsive cytochrome P450 1A1 and on a stably transfected dioxin-responsive element-driven reporter in human hepatoma cells.
Differential effects of dietary fatty acids on the regulation of CYP2E1 and protein kinase C in human hepatoma HepG2 cells.
Differential effects of mercury, lead and copper on the constitutive and inducible expression of aryl hydrocarbon receptor (AHR)-regulated genes in cultured hepatoma Hepa 1c1c7 cells.
Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs.
Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats.
Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7.
Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines.
Diflubenzuron, a benzoyl-urea insecticide, is a potent inhibitor of TCDD-induced CYP1A1 expression in HepG2 cells.
Diosmetin induces apoptosis by upregulating p53 via the TGF-? signal pathway in HepG2 hepatoma cells.
Dioxin induces localized, graded changes in chromatin structure: implications for Cyp1A1 gene transcription.
Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells.
Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.
Disruption of dioxin-inducible phase I and phase II gene expression patterns by cadmium, chromium, and arsenic.
Dissecting the expression landscape of cytochromes P450 in hepatocellular carcinoma: towards novel molecular biomarkers.
DNA binding by the heterodimeric Ah receptor. Relationship to dioxin-induced CYP1A1 transcription in vivo.
DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells.
DNA transfection of a gene repressing aryl hydrocarbon hydroxylase induction.
DNA-mediated restoration of aryl hydrocarbon hydroxylase induction in a mouse hepatoma mutant defective in nuclear translocation of the Ah receptor.
Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage.
Down-regulation of aryl hydrocarbon receptor-regulated genes by tumor necrosis factor-alpha and lipopolysaccharide in murine hepatoma Hepa 1c1c7 cells.
Down-regulation of cytochrome P450 2C8 by 3-methylcholanthrene in human hepatocellular carcinoma cell lines.
Down-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor.
Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma.
Effect of a negative regulatory element (NRE) on the human CYP1A1 gene expression in breast carcinoma MCF-7 and hepatoma HepG2 cells.
Effect of bixin and norbixin on the expression of cytochrome P450 in HepG2 cell line.
Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells.
Effect of some carcinogenic and non-carcinogenic polycyclic aromatic hydrocarbons on gap junction intercellular communication in hepatoma cell cultures.
Effect of strain differences and tumor presence on microsomal drug metabolism in the guinea pig: brief communication.
Effect of tamoxifen feeding on metabolic activation of tamoxifen by the liver of the rhesus monkey: does liver accumulation of inhibitory metabolites protect from tamoxifen-dependent genotoxicity and cancer?
Effects of aflatoxin B?, fumonisin B? and their mixture on the aryl hydrocarbon receptor and cytochrome P450 1A induction.
Effects of arachidonic acid and indomethacin on sister-chromatid exchange induction by polycyclic aromatic hydrocarbons in mammalian cell lines.
Effects of benzimidazole derivatives on cytochrome P450 1A1 expression in a human hepatoma cell line.
Effects of ethanol, dexamethasone and RU 486 on expression of cytochromes P450 2B, 2E, 3A and glutathione transferase pi in a rat hepatoma cell line (Fao).
Effects of fibrates, anti-inflammatory drugs and antidepressants in the fish hepatoma cell line PLHC-1: cytotoxicity and interactions with cytochrome P450 1A.
Effects of o,p'-DDT on the 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in murine Hepa-1c1c7 cells.
Effects of structure on binding to the 2,3,7,8-TCDD receptor protein and AHH induction--halogenated biphenyls.
Effects of substituents on the cytosolic receptor-binding avidities and aryl hydrocarbon hydroxylase induction potencies of 7-substituted 2,3-dichlorodibenzo-p-dioxins. A quantitative structure-activity relationship analysis.
Efficient one-step selection of hepatoma cell variants of a variety of phenotypes by use of aflatoxin B1.
Elevated glutathione level does not protect against chronic alcohol mediated apoptosis in recombinant human hepatoma cell line VL-17A over-expressing alcohol metabolizing enzymes - Alcohol dehydrogenase and Cytochrome P450 2E1.
Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells.
Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6.
Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes.
Establishment of a human hepatoma cell line, HLE/2E1, suitable for detection of p450 2E1-related cytotoxicity.
Establishment of a p-nitrophenol oxidation-based assay for the analysis of CYP2E1 activity in intact hepatocytes in vitro.
Establishment of cytochrome P450 3A4 and glutathione S-transferase A1-transfected human hepatoma cell line and functional analysis.
Establishment of mouse and rat hepatoma cell clones showing stable expression of rabbit cytochrome P450 IA2.
Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s.
Ethanol enhances hepatitis C virus replication through lipid metabolism and elevated NADH/NAD+.
Evaluation of a human hepatoma cell line as a target cell in genetic toxicology.
Evaluation of CYP3A4 inhibition and hepatotoxicity using DMSO-treated human hepatoma HuH-7 cells.
Evaluation of genipin on human cytochrome P450 isoenzymes and P-glycoprotein in vitro.
Evidence for the involvement of cytochrome P-450-dependent monooxygenase(s) in the formation of genotoxic metabolites from N-hydroxyurea.
Evidence that 2,3,7,8-tetrachlorodibenzo-p-dioxin induces NADPH cytochrome c (P-450) reductase in rat hepatoma cells in culture.
Expression of cathepsin B and aryl hydrocarbon hydroxylase activities, and of apolipoprotein B in human hepatoma cells maintained long-term in a serum-free medium.
Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to hepatitis B virus and aflatoxin B1-and 4-aminobiphenyl-DNA adducts.
Expression of cytochrome P450 in LEC rats during the development of hereditary hepatitis and hepatoma.
Expression of Cytochromes P-450 2E1, 3A4 and 1A1/1A2 in Growing and Confluent Human HepG2 Hepatoma Cells-Effect of Ethanol.
Expression of cytochromes P-450 in rat hepatoma cells. Analysis by monoclonal antibodies specific for cytochromes P-450 from rat liver induced by 3-methylcholanthrene or phenobarbital.
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells.
Failure of Ah receptor to mediate induction of cytochromes P450 in the CYP1 family in the human hepatoma line SK-Hep-1.
Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.
Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices.
Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells.
Fumonisin B1 modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b.
Functional activity of human hepatoma cells transfected with adenovirus-mediated hepatocyte nuclear factor (HNF)-4 gene.
Functional alterations of the endoplasmic reticulum and the detoxification systems during diethyl-nitrosamine carcinogenesis in rat liver.
Functional analysis of the human cytochrome P4501A1 (CYP1A1) gene enhancer.
Functional analysis of the transcriptional promoter for the CYP1A1 gene.
General review on in vitro hepatocyte models and their applications.
Genetic analysis of aflatoxin B1 activation in rat hepatoma cells.
Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1.
Genetic polymorphisms of cytochrome P450 in patients with hepatitis C virus-associated hepatocellular carcinoma.
Genetic Polymorphisms of Cytochrome P4501A1 (CYP1A1) and Glutathione S-Transferase P1 (GSTP1) and Risk of Hepatocellular Carcinoma Among Chronic Hepatitis C Patients in Egypt.
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma.
Genetic variants of ALDH2-rs671 and CYP2E1-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population.
Genistein affects expression of cytochrome P450 (CYP450) genes in hepatocellular carcinoma (HEPG2/C3A) cell line.
Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells.
Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.
Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells.
GSH/GSSG redox couple plays central role in aryl hydrocarbon receptor-dependent modulation of cytochrome P450 1A1.
Halogenated biphenyls as AHH inducers: effects of different halogen substituents.
Halogenated biphenyls: molecular toxicology.
Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms.
HBx inhibits CYP2E1 gene expression via downregulating HNF4? in human hepatoma cells.
Hepa-1 enzyme induction assay as an in vitro indicator of the CYP1A1-inducing potencies of laboratory rodent diets in vivo.
HepaRG cells as human-relevant in vitro model to study the effects of inflammatory stimuli on cytochrome P450 isoenzymes.
Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.
Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis.
Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.
Hepatocellular carcinoma: gene expression profiling and regulation of xenobiotic-metabolizing cytochromes P450.
Hepatocellular carcinoma: susceptibility markers.
High CYP2E1 activity correlates with hepatofibrogenesis induced by nitrosamines.
High expression of cytochrome P450 2a-5 (coumarin 7-hydroxylase) in mouse hepatomas.
Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells.
How the potency of the steroid RU486 is related to P450 activities induced by dexamethasone and phenobarbital in rat hepatoma cells.
Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin.
Human cDNA-expressed cytochrome P450 IA2: mutagen activation and substrate specificity.
Human CYP1B1-dependent genotoxicity of dioxin-like polychlorinated biphenyls in mammalian cells.
Human CYP2E1-activated mutagenicity of dioxin-like PCBs 105 and 118-Experimental data consistent with molecular docking results.
Human liver oxidative metabolism of O6-benzylguanine.
Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes.
Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1).
Identification and characterization of genes associated with human hepatocellular carcinogenesis.
Identification of a cell-specific transcription activation domain within the human Ah receptor nuclear translocator.
Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors.
Identification of CYP2C9*2 Allele in HepG2 Cell Line.
Identification of oxidized mitochondrial proteins in alcohol-exposed human hepatoma cells and mouse liver.
Identification of the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole, in cell culture medium, as a factor that controls the background aryl hydrocarbon receptor activity.
Identifying hepatocellular carcinoma-related hub genes by bioinformatics analysis and CYP2C8 is a potential prognostic biomarker.
IL-4-mediated transcriptional regulation of human CYP2E1 by two independent signaling pathways.
Immunochemically detected nuclear envelope-associated cytochrome P-450 component(s) in rat hepatocyte culture lines.
Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma.
Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody.
Impact of Alternaria toxins on CYP1A1 expression in different human tumor cells and relevance for genotoxicity.
In silico screening and analysis of nonsynonymous SNPs in human CYP1A2 to assess possible associations with pathogenicity and cancer susceptibility.
In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces amphiregulin gene expression in the developing mouse ureter.
In vitro toxicity and in silico docking analysis of two novel selective AH-receptor modulators.
In vivo/in vitro comparison of the pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl (PCB77).
Increased cytotoxicity of carbon tetrachloride in a human hepatoma cell line overexpressing cytochrome P450 2E1.
Increased effects of 2,5-dimethylcelecoxib on sensitivity of hepatocellular carcinoma cells to sorafenib via CYP3A5 expression and activation of AMPK.
Increased expression of drug-metabolizing enzymes in human hepatocarcinoma FLC-4 cells cultured on micro-space cell culture plates.
Increased oxidative stress and toxicity in ADH and CYP2E1 overexpressing human hepatoma VL-17A cells exposed to high glucose.
Inducing effects of dioxin-like polychlorinated biphenyls on CYP1A in the human hepatoblastoma cell line HepG2, the rat hepatoma cell line H4IIE, and rat primary hepatocytes: comparison of relative potencies.
Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol.
Induction by phenobarbital in McA-RH7777 rat hepatoma cells of a polycyclic hydrocarbon inducible cytochrome P450.
Induction of aryl hydrocarbon hydroxylase activity in cell cultures by aroclors, residues from yusho oil samples, and polychlorinated biphenyl residues from fish samples.
Induction of aryl hydrocarbon hydroxylase and demonstration of a specific nuclear receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in two human hepatoma cell lines.
Induction of CYP1A1 gene expression in H4-II-E rat hepatoma cells by benzo[e]pyrene.
Induction of CYP1A1 gene expression in mouse hepatoma cells by benzo[e]pyrene, a ligand of the 4S polycyclic hydrocarbon-binding protein.
Induction of cytochrome P-450 1A2 by oxidized tryptophan in Hepa lclc7 cells.
Induction of cytochrome P450 1A1 by ketoconazole and itraconazole but not fluconazole in murine and human hepatoma cell lines.
Induction of cytochrome P450 1A1 gene expression by a vitamin K3 analog in mouse hepatoma Hepa-1c1c7 cells.
Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells.
Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells by 6-nitrochrysene.
Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners.
Induction of cytochrome P4501A and endocrine disrupting effects of school incinerator residues.
Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage.
Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells.
Induction of cytochrome P4501A1 by ozone-oxidized tryptophan in Hepa lclc7 cells.
Induction of cytochrome P450IA1 in mouse hepatoma cells by several chemicals. Phenobarbital and TCDD induce the same form of cytochrome P450.
Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line.
Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5.
Induction of DNA damage by N-nitrosodiethylamine in rat hepatoma cells: correlation with cytochrome P450-mediated aldrin epoxidase activity.
Induction of enzyme activity in cell culture: a rapid screen for detection of planar polychlorinated organic compounds.
Induction of hepatic metabolic functions by a novel variant of hepatocyte nuclear factor 4?.
Induction of zone-like liver function gradients in HepG2 cells by varying culture medium height.
Influence of Mycoplasma arginini infection on the induction of aryl hydrocarbon hydroxylase by TCDD in rat hepatoma cell cultures.
Inhibition of benzo[a]pyrene metabolism by insulin, FITC-insulin and an FITC-insulin-antibody conjugate in the human hepatoma cell line HepG2.
Inhibition of calcitriol inactivating enzyme CYP24A1 gene expression by flavonoids in hepatocellular carcinoma cells under normoxia and hypoxia.
Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.
Inhibition of cytochrome P450 1A1 by antisense phosphorothioate oligonucleotide in Hepa lclc7 cells.
Inhibition of gap junction intercellular communications in cell culture by polycyclic aromatic hydrocarbons (PAH) in the absence of PAH metabolism.
Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Insulin down-regulates cytochrome P450 2B and 2E expression at the post-transcriptional level in the rat hepatoma cell line.
Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population.
Interaction between dose and susceptibility to environmental cancer: a short review.
Interaction of diuron and related substituted phenylureas with the Ah receptor pathway.
Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies.
Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells.
Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells.
Involvement of aryl hydrocarbon receptor in the cytotoxicity of corannulene and its derivatives.
Involvement of different pathways in the genotoxicity of nitropropanes in cultured mammalian cells.
Involvement of pregnane x receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes.
In vitro profiling of the potential endocrine disrupting activities affecting steroid and aryl hydrocarbon receptors of compounds and mixtures prevalent in human drinking water resources.
Itraconazole cis-diastereoisomers activate aryl hydrocarbon receptor AhR and pregnane X receptor PXR and induce CYP1A1 in human cell lines and human hepatocytes.
Janus kinase-dependent regulation of drug detoxifying protein expression by interleukin-22 in human hepatic cells.
JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes.
Ketoconazole Stereoisomers Differentially Induce Cytochrome P450 1A1 Between Human Hepatoma HepG2 and Mouse Hepatoma Hepa1c1c7 Cells.
Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7.
Lack of association between the functional polymorphisms in the estrogen-metabolizing genes and risk for hepatocellular carcinoma.
Lack of association of cytochrome P450 2E1 genetic polymorphisms with the risk of human hepatocellular carcinoma.
Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin.
Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization.
Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.
Loss of cyp1a1 messenger rna expression due to nonsense-mediated decay.
Marked increase of CYP24A1 mRNA level in hepatocellular carcinoma cell lines following vitamin D administration.
Measurement of Cytochrome P450 Enzyme Induction and Inhibition in Human Hepatoma Cells.
Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes.
Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo.
Mechanism of dioxin action: receptor-enhancer interactions in intact cells.
Mechanism of maintenance of liver-specific functions by DMSO in cultured rat hepatocytes.
Mechanism-based in vitro screening of potential cancer chemopreventive agents.
Mechanisms involved in lipid accumulation and apoptosis induced by 1-nitropyrene in Hepa1c1c7 cells.
Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells.
Mercury modulates the CYP1A1 at transcriptional and posttranslational levels in human hepatoma HepG2 cells.
Metabolic activation of the potent carcinogen dibenzo[a,h]anthracene by cDNA-expressed human cytochromes P450.
Metabolic characteristics and enflurane defluorination of cytochrome P450-dependent monooxygenases in human hepatocellular carcinoma.
Metabolic enzyme induction by HepG2 cells exposed to oxygenated and nonoxygenated polycyclic aromatic hydrocarbons.
Metabolic Susceptibility of 2-Chlorothioxanthone and Its Toxic Effects on mRNA and Protein Expression and Activities of Human CYP1A2 and CYP3A4 Enzymes.
Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity.
Methodological remarks concerning the recent meta-analysis on CYP1A1 polymorphisms-smoking interaction and hepatocellular carcinoma risk.
Methoxychlor suppresses the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible CYP1A1 expression in murine Hepa-1c1c7 cells.
Metoronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes.
MG-132 inhibits the TCDD-mediated induction of Cyp1a1 at the catalytic activity but not the mRNA or protein levels in Hepa 1c1c7 cells.
Microfluidic geometric metering-based multi-reagent mixture generator for robust live cell screening array.
Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats.
Mixture effects between different azoles and ?-naphthoflavone on the CYP1A biomarker in a fish cell line.
Modulation of aryl hydrocarbon receptor-regulated gene expression by arsenite, cadmium, and chromium.
Modulation of aryl hydrocarbon receptor-regulated genes by acute administration of ammonium metavanadate in kidney, lung and heart of C57BL/6 mice.
Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation.
Modulation of carcinogen metabolizing enzymes by chromanone A; a new chromone derivative from algicolous marine fungus Penicillium sp.
Modulation of cytochrome P4501-mediated bioactivation of benzo[a]pyrene by volatile allyl sulfides in human hepatoma cells.
Modulation of cytochrome P4501A1 activity by ascorbigen in murine hepatoma cells.
Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.
Modulation of TCDD-mediated induction of cytochrome P450 1A1 by mercury, lead, and copper in human HepG2 cell line.
Molecular basis for the transport of cytochrome P450 2E1 to the plasma membrane.
Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma.
Molecular Links between Alcohol and Tobacco Induced DNA Damage, Gene Polymorphisms and Patho-physiological Consequences: A Systematic Review of Hepatic Carcinogenesis.
Mouse dioxin-inducible cytosolic aldehyde dehydrogenase-3: AHD4 cDNA sequence, genetic mapping, and differences in mRNA levels.
Mouse dioxin-inducible NAD(P)H: menadione oxidoreductase: NMO1 cDNA sequence and genetic differences in mRNA levels.
MRNA levels of two different enzymes in hepatocellular carcinoma.
Multiparametric characterization by flow cytometry of flow-sorted subpopulations of a human hepatoma cell line useful for drug research.
Multivariate modelling of polychlorinated biphenyl-induced CYP1A activity in the MH1C1 rat hepatoma cell line.
Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline by complementary DNA-expressed human liver P-450.
N-Hydroxylation of 4-Aminobiphenyl by CYP2E1 Produces Oxidative Stress in a Mouse Model of Chemically Induced Liver Cancer.
Natural furocoumarins as inducers and inhibitors of cytochrome P450 1A1 in rat hepatocytes.
Nicotine stimulates CYP1A1 expression in human hepatocellular carcinoma cells via AP-1, NF-?B, and AhR.
Nigramide C is a Natural Agonist of Human Pregnane X Receptor.
Nitric oxide and interleukin-1? stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes.
Nitric Oxide Mediated Degradation of CYP2A6 via the Ubiquitin-Proteasome Pathway in Human Hepatoma Cells.
No role of protected region B of human cytochrome P4501A2 gene (CYP1A2) as an AP-1 response element.
Novel transcriptional regulation of the human CYP3A7 gene by Sp1 and Sp3 through nuclear factor kappa B-like element.
Nuclear transcription factor Oct-1 binds to the 5'-upstream region of CYP1A1 and negatively regulates its expression.
Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene.
Occurrence of PCDD/PCDFs and PCBs in soil and comparison with CYP1A response in PLHC-1 cell line.
Oct-1 transcription factor is a negative regulator of rat CYP1A1 expression via an octamer sequence in its negative regulatory element.
Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYP1A1 activity in human and mouse hepatoma cells.
Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements.
Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
Overexpression of CYP2E1 enhances sensitivity of hepG2 cells to fas-mediated cytotoxicity.
Oxidative metabolism of bunitrolol by complementary DNA-expressed human cytochrome P450 isozymes in a human hepatoma cell line (Hep G2) using recombinant vaccinia virus.
Oxidative stress, toxicology, and pharmacology of CYP2E1.
p38 Mitogen Activated Protein Kinase Regulates the Nuclear Receptor CAR to Activate the CYP2B6 Gene.
Paclitaxel Nanoparticles Induce Apoptosis and Regulate TXR1, CYP3A4 and CYP2C8 in Breast Cancer and Hepatoma Cells.
Palmatine activates AhR and upregulates CYP1A activity in HepG2 cells but not in human hepatocytes.
Patterns of expression of cytochrome P450 genes in progression of hepatitis C virus-associated hepatocellular carcinoma.
PCB isomers and congeners: induction of aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase enzyme activities in rat hepatoma cells.
Peganum Harmala L. Differentially Modulates Cytochrome P450 Gene Expression in Human Hepatoma HepG2 Cells.
Peganum harmala L. differentially modulates cytochrome P450 gene expression in human hepatoma HepG2 cells.
Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter.
Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma.
Phase II study of 4-ipomeanol, a naturally occurring alkylating furan, in patients with advanced hepatocellular carcinoma.
Phenobarbital induces cytochrome P-450- and cytochrome P-448-dependent monooxygenases in rat hepatoma cells.
Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis.
Phenobarbital, dexamethasone and benzanthracene induce several cytochrome P450 mRNAs in rat hepatoma cells.
Piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme and not by down regulation of CYP1A1 gene expression in the rat hepatoma 5L cell line.
Plasma caffeine metabolite ratio (17X/137X) in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2.
Polybrominated dibenzo-p-dioxins and related compounds: quantitative in vivo and in vitro structure-activity relationships.
Polychlorinated dibenzo-p-dioxins: quantitative in vitro and in vivo structure-activity relationships.
Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity.
Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells.
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Polymorphisms of the CYP1B1 gene and hepatocellular carcinoma risk in a Chinese population.
Post-translational inhibition of cytochrome P-450 2E1 expression by chlomethiazole in Fao hepatoma cells.
Posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by methylmercury in HepG2 cells: A role of heme oxygenase-1.
Potentiating effect of graphene nanomaterials on aromatic environmental pollutant-induced cytochrome P450 1A expression in the topminnow fish hepatoma cell line PLHC-1.
Probing the control elements of the CYP1A1 switching module in H4IIE hepatoma cells.
Profiling cytochrome P450 family 4 gene expression in human hepatocellular carcinoma.
Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells.
Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor.
Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR.
Pungent ginger components modulates human cytochrome P450 enzymes in vitro.
Purification and characterization of recombinant rat hepatic CYP4F1.
Quantitative structure-activity relationships: analysis of interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2-substituted analogues with rat, mouse, guinea pig, and hamster cytosolic receptor.
Quercetin, Quercetin Glycosides and Taxifolin Differ in their Ability to Induce AhR Activation and CYP1A1 Expression in HepG2 Cells.
Quercetin, Resveratrol, and Curcumin Are Indirect Activators of the Aryl Hydrocarbon Receptor (AHR).
Rabbit cytochrome P450 4B1: A novel prodrug activating gene for pharmacogene therapy of hepatocellular carcinoma.
Rat CYP1A1 negative regulatory element: biological activity and interaction with a protein from liver and hepatoma cells.
Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells.
Regulation of CYP1A induction in hepatoma 27 depending on the site of transplantation.
Regulation of CYP1A1 by indolo[3,2-b]carbazole in murine hepatoma cells.
Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone.
Regulation of Cyp1a1 induction by dioxin as a function of cell cycle phase.
Regulation of CYP1A1 transcription via the metabolism of the tryptophan-derived 6-formylindolo[3,2-b]carbazole.
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction.
Regulation of NAD(P)H:quinone oxidoreductase 1 gene expression by CYP1A1 activity.
Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis C virus replicon-expressing cells.
Regulation of [Ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[1,2-b]indole in mouse hepatoma cell lines.
Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.
Regulatory sequence responsible for insulin destabilization of cytochrome P450 2B1 (CYP2B1) mRNA.
Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase.
Relationship of ALDH2 rs671 and CYP2E1 rs2031920 with hepatocellular carcinoma susceptibility in East Asians: a meta-analysis.
Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice.
Relative potencies of PAHs and PCBs based on the response of human cells.
Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP).
Restoration of hydroperoxide-dependent lipid peroxidation by 3-methylcholanthrene induction of cytochrome P-448 in hepatoma microsomes.
Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the Aryl Hydrocarbon Receptor complex and RNA Polymerase II to the regulatory regions of the corresponding genes.
Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor.
Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide.
Role of cytochrome P450 enzyme induction in the metabolic activation of benzo[c]phenanthrene in human cell lines and mouse epidermis.
Role of cytochrome P450 in the control of the production of erythropoietin.
Role of DNA methylation-related chromatin remodeling in aryl hydrocarbon receptor-dependent regulation of T-2 toxin highly inducible Cytochrome P450 1A4 gene.
Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes.
Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator.
Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide.
RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma.
Screening of fresh water fish extracts for enzyme-inducing substances by an aryl hydrocarbon hydroxylase induction bioassay technique.
Selective fast degradation of cytochrome P-450 2E1 in serum-deprived hepatoma cells by a mechanism sensitive to inhibitors of vesicular transport.
Selective induction of the CYP3A family by endosulfan and DNA-adduct formation in different hepatic and hepatoma cells.
Selective suppression of the catalytic activity of cDNA-expressed cytochrome P4502B1 toward polycyclic hydrocarbons in the microsomal membrane: modification of this effect by specific amino acid substitutions.
Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.
Severely Impaired and Dysregulated Cytochrome P450 Expression and Activities in Hepatocellular Carcinoma: Implications for Personalized Treatment in Patients.
Short and long term effects of cytoskeleton-disrupting drugs on cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells: suppression by the microtubule inhibitor nocodazole.
Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells.
Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: A study in human keratinocytes and human hepatoma cells.
SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor.
Single cell analysis of switch-like induction of CYP1A1 in liver cell lines.
Single-step phototoxic selection procedure for isolating cells that possess aryl hydrocarbon hydroxylase.
Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase.
Sister-chromatid exchange induction by indirect mutagens/carcinogens, aryl hydrocarbon hydroxylase activity and benzo[alpha]pyrene metabolism in cultured human hepatoma cells.
Sorafenib metabolism is significantly altered in the liver tumor tissue of hepatocellular carcinoma patient.
Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity.
Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: A PXR dependent mechanism.
Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s.
Structural and functional characterization of the 5'-flanking region of the rat and human cytochrome P450 2E1 genes: identification of a polymorphic repeat in the human gene.
Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells.
Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450.
Substituted polychlorinated dibenzofuran receptor binding affinities and aryl hydrocarbon hydroxylase induction potencies--a QSAR analysis.
Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells.
Superinduction of Oxidized Tryptophan-Inducible Cytochrome P450 1A1 by Cycloheximide in Hepa lclc7 Cells.
Suppression of aryl hydrocarbon hydroxylase activity in human primary lung carcinoma x mouse hepatoma somatic cell hybrids.
Suppression of CYP1A1 expression by naringenin in murine Hepa-1c1c7 cells.
Suppression of CYP2C9 by MicroRNA hsa-miR-128-3p in Human Liver Cells and Association with Hepatocellular Carcinoma.
Suppression of cytochrome P450 (Cyp1a-1) induction in mouse hepatoma Hepa-1C1C7 cells by methoxsalen.
Suppression of Cytochrome P450 1A1 Expression Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mouse Hepatoma Hepa-1c1c7 Cells Treated with Serum of (-)-Epigallocatechin-3-gallate- and Green Tea Extract-Administered Rats.
Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C.
Suppression of TCDD-induced cytochrome P450 IA1 activity by staurosporine in mouse primary hepatocyte cultures and hepatoma cells.
Suppressive effects of caraway (Carum carvi) extracts on 2, 3, 7, 8-tetrachloro-dibenzo-p-dioxin-dependent gene expression of cytochrome P450 1A1 in the rat H4IIE cells.
Suspension-mediated induction of Hepa 1c1c7 Cyp1a-1 expression is dependent on the Ah receptor signal transduction pathway.
Sustained induction of cytochrome P4501A1 in human hepatoma cells by co-exposure to benzo[a]pyrene and 7H-dibenzo[c,g]carbazole underlies the synergistic effects on DNA adduct formation.
Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery.
TCDD receptor ligands present in extracts of urban air particulate matter induce aryl hydrocarbon hydroxylase activity and cytochrome P-450c gene expression in rat hepatoma cells.
tert-Butylhydroquinone is a novel aryl hydrocarbon receptor ligand.
The Ah regulatory gene product. Survey of nineteen polycyclic aromatic compounds' and fifteen benzo[a]pyrene metabolites' capacity to bind to the cytosolic receptor.
The Alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome P450 1A1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor.
The anti-hepatitis B virus therapeutic potential of anthraquinones derived from Aloe vera.
The aromatic hydrocarbon receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin and variable levels of induced aryl hydrocarbon hydroxylase activity in clones of mouse hepatoma cells.
The aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl induces distinct patterns of gene expression between hepatoma and glioma cells: chromatin remodeling as a mechanism for selective effects.
The CYP2B1 proximal promoter contains a functional C/EBP regulatory element.
The cytochrome P450 1A gene (CYP1A) from European flounder (Platichthys flesus), analysis of regulatory regions and development of a dual luciferase reporter gene system.
The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons.
The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase.
The effect of interferon-? on the expression of cytochrome P450 3A4 in human hepatoma cells.
The effect of transcatheter arterial chemoembolization on CYP1A2 activity in patients with hepatocellular carcinoma.
The effect of transcatheter arterial chemoembolization on phase II drug metabolism enzymes in patients with hepatocellular carcinoma.
The effects of inducing agents on cytochrome P450 and UDP-glucuronyltransferase activities in human HEPG2 hepatoma cells.
The glycogen synthase kinase inhibitor 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763) is a partial agonist of the aryl hydrocarbon receptor.
The highly bioactive molecule and signal substance 6-formylindolo[3,2-b]carbazole (FICZ) plays bi-functional roles in cell growth and apoptosis in vitro.
The HNF1?-Regulated LncRNA HNF1?-AS1 Is Involved in the Regulation of Cytochrome P450 Expression in Human Liver Tissues and Huh7 Cells.
The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction.
The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2.
The induction of the human hepatic CYP2E1 gene by interleukin 4 is transcriptional and regulated by protein kinase C.
The inhibition effect of 2,3,7,8-tetrachlorinated dibenzo-p-dioxin-induced aryl hydrocarbon receptor activation in human hepatoma cells with the treatment of cadmium chloride.
The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes.
The mechanism of action of alpha-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
The murine Cyp1a-1 gene negatively regulates its own transcription and that of other members of the aromatic hydrocarbon-responsive [Ah] gene battery.
The p38 MAPK Inhibitor SB203580 Induces Cytochrome P450 1A1 Gene Expression in Murine and Human Hepatoma Cell Lines through Ligand-Dependent Aryl Hydrocarbon Receptor Activation.
The Synergistic Antitumor Effect of Tanshinone IIA Plus Adriamycin on Human Hepatocellular Carcinoma Xenograft in BALB/C Nude Mice and Their Influences on Cytochrome P450 CYP3A4 In Vivo.
Three new alternative splicing variants of human cytochrome P450 2D6 mRNA in human extratumoral liver tissue.
Time-dependent transcriptional induction of CYP1A1, CYP1A2 and CYP1B1 mRNAs by H+/K+ -ATPase inhibitors and other xenobiotics.
trans-Acting factors, detoxication enzymes and hepatitis B virus replication in a novel set of human hepatoma cell lines.
Transactivation domains facilitate promoter occupancy for the dioxin-inducible CYP1A1 gene in vivo.
Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin.
Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1.
Transcriptional and post-translational regulation of CYP1A1 by primaquine.
Transcriptional and posttranscriptional regulation of CYP1A1 by vanadium in human hepatoma HepG2 cells.
Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol.
Transcriptional and posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by lead in HepG2 cells: a role of heme oxygenase.
Transcriptional regulation of the human CYP1B1 gene. Evidence for involvement of an aryl hydrocarbon receptor response element in constitutive expression.
Transcriptional regulation of the human CYP2A6 gene.
Transcriptome Analysis of WHV/c-myc Transgenic Mice Implicates Cytochrome P450 Enzyme 17A1 as a Promising Biomarker for Hepatocellular Carcinoma.
Trout CYP1A3 Gene: Recognition of Fish DNA Motifs by Mouse Regulatory Proteins.
Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors.
Up-regulation of CYP1A1 by rutaecarpine is dependent on aryl hydrocarbon receptor- and calcium.
Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment.
Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.
Use of bioassays and sediment polycyclic aromatic hydrocarbon concentrations to assess toxicity at coastal sites impacted by Hurricane Katrina.
Use of effect-directed analysis for the identification of organic toxicants in surface flow constructed wetland sediments.
Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines.
Vinclozolin, a widely used fungizide, enhanced BaP-induced micronucleus formation in human derived hepatoma cells by increasing CYP1A1 expression.
Water exposure assessment of aryl hydrocarbon receptor agonists in Three Gorges Reservoir, China using SPMD-based virtual organisms.
Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7.
[A case-control study on the association of hepatocellular carcinoma with genetic polymorphisms of CYP3A5 in a highly aflatoxin B1 contaminated Guangxi area.]
[Ah receptor-independent inhibition of gap junction intercellular communications in hepatoma cell culture 27 by polycyclic aromatic hydrocarbons]
[Association between aldehyde dehydrogenase-2/cytochrome P450 2E1 genetic polymorphism and habit of alcohol drinking and the susceptibility of hepatocellular carcinoma]
[Enzymes metabolizing xenobiotics in spontaneous tumors in mice]
[Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro].
[Induction of cytochrome P450 2A5 in transplanted mouse hepatoma]
[Mechanism and clinical significance of HBx-mediated inhibition of CYP2E1 expression in the human HepG2 hepatoma cell line].
[New perspectives in the use of human hepatocytes in the preclinical drug development process]
[Study on the relationship between familial clustering of hepatocellular carcinoma and polymorphism of cytochrome P450 2E1 gene in Zhuang population, Guangxi]
[Vitamin D metabolism and signaling in human hepatocellular carcinoma and surrounding non-tumorous liver].
Carcinoma, Intraductal, Noninfiltrating
Utilizing mobile networks for the detection of clinically relevant interactions between chemotherapy regimens and complementary and alternative medicines.
Carcinoma, Large Cell
Identification of a novel co-transcription of P450/1A1 with telomerase in A549.
Carcinoma, Non-Small-Cell Lung
A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population.
A regulatory variant in CYP2E1 affects the risk of lung squamous cell carcinoma.
Altered regulation of the cytochrome P4501A1 gene: novel inducer-independent gene expression in pulmonary carcinoma cell lines.
Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer.
Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India.
Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer.
Combined effects of serum trace metals and polymorphisms of CYP1A1 or GSTM1 on non-small cell lung cancer: A hospital based case-control study in China.
CYP1A1 Ile462Val polymorphism and the risk of non-small cell lung cancer in a Chinese population.
CYP2E1 polymorphism, cigarette smoking, p53 expression, and survival in non-small cell lung cancer: a long term follow-up study.
CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in Chinese Han population.
Cytochrome P450 1B1 (CYP1B1) polymorphisms are associated with clinical outcome of docetaxel in non-small cell lung cancer (NSCLC) patients.
Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.
Cytochrome P450 ?-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer.
Cytochrome P450 expression (CYP) in non-small cell lung cancer.
Cytochrome P450 in non-small cell lung cancer related to exogenous chemical metabolism.
Decreased expression of cytochrome p450 1B1 in non-small cell lung cancer.
Determinants of Gefitinib toxicity in advanced non-small cell lung cancer (NSCLC): a pharmacogenomic study of metabolic enzymes and transporters.
Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients.
Erlotinib treatment induces cytochrome P450 3A activity in non-small cell lung cancer patients.
Expression of aromatase CYP19 and its relationship with parameters in NSCLC.
Expression of cytochrome P450 2A13 in human non-small cell lung cancer and its clinical significance.
Expression of cytochrome P450 in non-small cell lung cancer.
Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in non-small cell lung cancer.
GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels.
Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis.
Interaction of the CYP1A1 gene polymorphism and smoking in non-small cell lung cancer susceptibility.
Investigating the influence of relevant pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of orally administered docetaxel combined with ritonavir.
MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1.
Overexpression of cytochrome P450 1B1 in advanced non-small cell lung cancer: a potential therapeutic target.
p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer.
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Prognostic significance of germ line polymorphisms of the CYP1A1 and glutathione S-transferase genes in patients with non-small cell lung cancer.
Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer.
Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism.
The Effect of Rifampin on the Pharmacokinetics and Safety of Lorlatinib: Results of a Phase One, Open-Label, Crossover Study in Healthy Participants.
Carcinoma, Ovarian Epithelial
Association of caffeine intake and CYP1A2 genotype with ovarian cancer.
CYP1B1 enhances the resistance of epithelial ovarian cancer cells to paclitaxel in vivo and in vitro.
CYP1B1 expression in ovarian cancer in the laying hen Gallusdomesticus.
Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression.
Genetic variation of CYP3A5 influences paclitaxel/carboplatin-induced toxicity in Chinese epithelial ovarian cancer patients.
Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk.
Carcinoma, Papillary
Role of the N-acetyltransferase 2 detoxification system in thyroid cancer susceptibility.
Smoking and susceptibility to thyroid cancer: an inverse association with CYP1A1 allelic variants.
Carcinoma, Renal Cell
Association between cytochrome P450 1A1 (CYP1A1) gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis.
Cell-specific regulation of human CYP1A1 and CYP1B1 genes.
CYP1A1 activity in renal cell carcinoma and in adjacent normal renal tissue.
CYP1B1 gene: Implications in glaucoma and cancer.
CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma.
CYP3A5 and ABCB1 polymorphisms as predictors for sunitinib outcome in metastatic renal cell carcinoma.
Cytochrome P450 1B1 polymorphisms and risk of renal cell carcinoma in men.
Cytochrome P450 CYP1B1 activity in renal cell carcinoma.
Cytochrome P450 CYP3A in human renal cell cancer.
Effect of the CYP3A5 and ABCB1 genotype on exposure, clinical response and manifestation of toxicities from sunitinib in Asian patients.
GSTT1, GSTM1, and CYP1B1 gene polymorphisms and susceptibility to sporadic renal cell cancer.
Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.
Important role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistance.
Induction of cytochrome P450 1B1 and catechol estrogen metabolism in ACHN human renal adenocarcinoma cells.
Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma.
Polymorphisms of the CYP1B1 gene as risk factors for human renal cell cancer.
Relationship Between CYP1A1 Genetic Polymorphisms and Renal Cancer in China.
Relevance of CYP3A5 Expression on the Clinical Outcome of Patients With Renal Cell Carcinoma.
Renal cell carcinoma: etiology, incidence and epidemiology.
Retraction: Polymorphisms of the CYP1B1 Gene as Risk Factors for Human Renal Cell Cancer.
Risk of renal cell carcinoma and polymorphism in phase I xenobiotic metabolizing CYP1A1 and CYP2D6 enzymes.
Sensitivity of renal cell carcinoma to aminoflavone: role of CYP1A1.
Superoxide dismutase and cytochrome P450 isoenzymes might be associated with higher risk of renal cell carcinoma in male patients.
Suppression of cytochrome P450 1A1 and 4A1 gene expression in renal carcinomas of TSC2 gene mutant (Eker) rats.
Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential.
Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma.
Carcinoma, Small Cell
Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens.
Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population.
Carcinoma, Squamous Cell
A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years.
A regulatory variant in CYP2E1 affects the risk of lung squamous cell carcinoma.
Activation and overexpression of the aryl hydrocarbon receptor contribute to cutaneous squamous cell carcinomas: an immunohistochemical study.
Allelic variations in CYP2D6 gene and susceptibility to cervical cancer.
Altered patterns of cutaneous xenobiotic metabolism in UVB-induced squamous cell carcinoma in SKH-1 hairless mice.
Analysis of the role of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 gene in the risk of squamous cell carcinoma.
Association and treatment response to capecitabine-based chemoradiotherapy with CYP2C9 polymorphism in head and neck cancer.
Association of aryl hydrocarbon receptor and cytochrome P4501B1 expressions in human non-small cell lung cancers.
Association of cigarette smoking and CYP1A1 polymorphisms with adenocarcinoma of the lung by grades of differentiation.
Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma.
Association of cytochrome P450 1B1 haplotypes with head and neck cancer risk.
Association of cytochrome P450 2C9 polymorphism with locally advanced head and neck squamous cell carcinoma and response to concurrent cisplatin-based radical chemoradiation.
Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus.
Association of polymorphism in cytochrome P450 2C9 with susceptibility to head and neck cancer and treatment outcome.
Association of poor metabolizers of cytochrome P450 2C19 with head and neck cancer and poor treatment response.
Association of Smoking and XPG, CYP1A1, OGG1, ERCC5, ERCC1, MMP2, and MMP9 Gene Polymorphisms with the early detection and occurrence of Laryngeal Squamous Carcinoma.
Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line.
Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects.
Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer.
Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis.
CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population.
CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil.
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.
CYP1A1 Ile462Val Polymorphism Contributes to Lung Cancer Susceptibility among Lung Squamous Carcinoma and Smokers: A Meta-Analysis.
CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma.
CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma.
CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population.
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
CYP2E1 G1532C, NQO1 Pro187Ser, and CYP1B1 Val432Leu polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck.
Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma.
Cytochrome P450 2E1 and head and neck cancer: Interaction with genetic and environmental risk factors.
Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.
Eldecalcitol (ED-71), an analog of 1?,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas.
Epigenetic and genetic dissections of UV-induced global gene dysregulation in skin cells through multi-omics analyses.
Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus.
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Genetic polymorphism of xenobiotic metabolising enzymes in Slovenian lung cancer patients.
Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population.
Genetic polymorphisms in Cytochrome P4501B1 and susceptibility to Head and Neck Cancer.
Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.
Genetic polymorphisms in the Cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx.
Genetic variants in CYP and GST genes, smoking and risk for head and neck cancers: a gene-environment interaction hospital-based case-control study among Canadian Caucasians.
Genome-wide association study of familial lung cancer.
Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions.
GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels.
GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.
Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.
hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.
Immunohistochemical localization of cytochrome P450 2E1 in human pulmonary carcinoma and normal bronchial tissue.
Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China.
Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population.
Intake of flavonoids and lung cancer.
Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer.
Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response.
Leu432Val Polymorphism of CYP1B1 is Not Associated with Squamous Cell Carcinoma of Esophagus--a Case-Control Study from Kashmir, India.
Meta-analyses of the effect of CYP1A1 and CYP2D6 polymorphisms on the risk of head and neck squamous cell carcinoma.
New strategy for the identification of squamous carcinoma antigens that induce therapeutic immune responses in tumor-bearing mice.
p53 gene mutations, and CYP1A1 and GSTM1 genotypes in pulmonary squamous cell carcinomas.
Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.
Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men.
Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome.
Polymorphism in cytochrome P4501A1 is significantly associated with head and neck cancer risk.
Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients.
Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India.
Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe.
Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk.
Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population.
Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols.
Quantitative assessment of the influence of CYP1B1 polymorphisms and head and neck squamous cell carcinoma risk.
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.
Synergistic association of CYP1A1 polymorphisms with increased susceptibility to squamous cell lung cancer in north Indian smokers.
The frequency of cytochrome P450 2E1 polymorphisms in Black South Africans.
Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population.
[Applications of aryl hydrocarbon hydroxylase in diagnosis of lung cancer]
[First results on the influence of polymorphisms at glutathione S-transferase, cytochrome P450, and tumor necrosis factor gene loci on the development of multiple head and neck cancer]
[Genetic polymorphism of cytochrome P4501A1 and susceptibility to laryngeal carcinoma]
[Influence of glutathione s-transferase and cytochrome p450 polymorphisms on prognosis of head and neck cancer]
[Role of metabolic polymorphisms in lung carcinogenesis]
[Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China.]
[Study on the Difference of Gene Expression between Central and Peripheral Lung Squamous Cell Carcinoma Based on TCGA Database].
Carcinoma, Transitional Cell
Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.
Aryl hydrocarbon hydroxylase induction levels in patients with malignant tumors associated with smoking.
Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer.
Cytochrome P450 isoenzyme mRNA expression pattern in human urinary bladder malignancies and normal urothelium.
Cardiomegaly
3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats.
Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart.
Alterations in cytochrome P450-derived arachidonic acid metabolism during pressure overload-induced cardiac hypertrophy.
CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK?2 and enhancing nuclear translocation of Akt1.
Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line.
Dasatinib induces gene expression of CYP1A1, CYP1B1, and cardiac hypertrophy markers (BNP, ?-MHC) in rat cardiomyocyte H9c2 cells.
Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway.
Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol.
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy.
Fluconazole Represses Cytochrome P450 1B1 and Its Associated Arachidonic Acid Metabolites in the Heart and Protects Against Angiotensin II-Induced Cardiac Hypertrophy.
Identification of 19-(S/R)Hydroxyeicosatetraenoic Acid as the First Endogenous Noncompetitive Inhibitor of Cytochrome P450 1B1 with Enantioselective Activity.
Impact of cigarette smoke exposure on the expression of cardiac hypertrophic genes, cytochrome P450 enzymes, and oxidative stress markers in rats.
In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology.
Inhibition of CYP1B1 ameliorates cardiac hypertrophy induced by uremic toxin.
Inhibition of Mid-chain HETEs Protects Against Angiotensin II-induced Cardiac Hypertrophy.
Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats.
Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1.
Resveratrol attenuates angiotensin II-induced cellular hypertrophy through the inhibition of CYP1B1 and the cardiotoxic mid-chain HETE metabolites.
Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy.
Testosterone, cytochrome P450, and cardiac hypertrophy.
The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats.
The role of cytochrome P450 1B1 and its associated mid-chain hydroxyeicosatetraenoic acid metabolites in the development of cardiac hypertrophy induced by isoproterenol.
Cardiomyopathies
Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice.
Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity.
Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W) dilated cardiomyopathy transgenic mice.
Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms.
Cardiomyopathy, Alcoholic
Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy.
CYP2J2-derived EETs attenuated ethanol-induced myocardial dysfunction through inducing autophagy and reducing apoptosis.
Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis.
Cardiomyopathy, Dilated
Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice.
Gene expression in distinct regions of the heart.
Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W) dilated cardiomyopathy transgenic mice.
Metabolism of arachidonic acid by the cytochrome P450 enzyme in patients with chronic Keshan disease and dilated cardiomyopathy.
Molecular chaperone, HSP60, and cytochrome P450 2E1 co-expression in dilated cardiomyopathy.
Cardiotoxicity
Acute arsenic toxicity alters cytochrome P450 and soluble epoxide hydrolase and their associated arachidonic acid metabolism in C57Bl/6 mouse heart.
Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats.
Acute Doxorubicin toxicity differentially alters cytochrome p450 expression and arachidonic Acid metabolism in rat kidney and liver.
Antihistamines.
Bortezomib: new indication. Second-line treatment of myeloma: limited efficacy, major risks.
Chronic Doxorubicin Cardiotoxicity Modulates Cardiac Cytochrome P450-Mediated Arachidonic Acid Metabolism in Rats.
Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore.
Cyp1 Inhibition Prevents Doxorubicin-Induced Cardiomyopathy in a Zebrafish Heart-Failure Model.
CYP1A in TCDD toxicity and in physiology-with particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates.
CYP1B1 as a therapeutic target in cardio-oncology.
CYP1B1 inhibition attenuates doxorubicin-induced cardiotoxicity through a mid-chain HETEs-dependent mechanism.
CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system.
Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes.
Embryonic cardiotoxicity of weak aryl hydrocarbon receptor agonists and CYP1A inhibitor fluoranthene in the Atlantic killifish (Fundulus heteroclitus).
Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase.
Liposomal co-delivered oleanolic acid attenuates doxorubicin-induced multi-organ toxicity in hepatocellular carcinoma.
Machine learning models for classification tasks related to drug safety.
Major Cardiac-Psychiatric Drug-Drug Interactions: a Systematic Review of the Consistency of Drug Databases.
Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative.
Metabolism and Disposition of Prescription Opioids: A Review.
Molecular toxicological alterations in the mouse hearts induced by sub-chronic thiazolidinedione drugs administration.
Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish.
Near-fatal tramadol cardiotoxicity in a CYP2D6 ultrarapid metabolizer.
QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations.
Sunitinib: new drug. For some gastrointestinal stromal tumours.
The metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes.
The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model.
The Role of Soluble Epoxide Hydrolase Enzyme on Daunorubicin-Mediated Cardiotoxicity.
The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish.
Thymoquinone reduces mitochondrial damage and death of cardiomyocytes induced by clozapine.
Using Genome-Wide Association Studies to Identify Genes Important in Serious Adverse Drug Reactions.
Utility of protein structures in overcoming ADMET-related issues of drug-like compounds.
Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists.
[Long QT and torsade de pointes in a patient with acquired human immunodeficiency virus infection in multitherapy with drugs affecting cytochrome P450]
`Cadmium induced cardiac inflammation in chicken (Gallus gallus) via modulating cytochrome P450 systems and Nrf2 mediated antioxidant defense.
Cardiovascular Diseases
A functional polymorphism in the CYP3A4 gene is associated with increased risk of coronary heart disease in the Chinese Han population.
Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.
Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone.
Association of CYP2C19 variants and epoxyeicosatrienoic acids on patients with microvascular angina.
Association of CYP3A4*1G and CYP3A5*3 With the 1-year Outcome of Acute Ischemic Stroke in the Han Chinese Population.
Biosynthesis of P450 products of arachidonic acid in humans: increased formation in cardiovascular disease.
Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats.
Clinical implications of pharmacogenetics of cytochrome P450 drug metabolizing enzymes.
Constitutive expression and inducibility of CYP1A1 in the H9c2 rat cardiomyoblast cells.
Contribution of CYP24A1 variants in coronary heart disease among the Chinese population.
Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke.
CYP1B1 as a therapeutic target in cardio-oncology.
CYP1B1 genotype and risk of cardiovascular disease, pulmonary disease, and cancer in 50,000 individuals.
CYP2C19 variants and epoxyeicosatrienoic acids in patients with microvascular angina.
CYP2J2 epoxygenase membrane anchor plays an important role in facilitating electron transfer from CPR.
CYP2J2-Derived EETs Attenuated Angiotensin II-Induced Adventitial Remodeling via Reduced Inflammatory Response.
Cytochrome P450 2C19*2 polymorphism in patients with stable coronary heart disease and risk for secondary cardiovascular disease events: results of a long-term follow-up study in routine clinical care.
Cytochrome p450 enzymes and cardiovascular disease.
Cytochrome p450 enzymes in the bioactivation of polyunsaturated Fatty acids and their role in cardiovascular disease.
Cytochrome P450 Pathway Contributes to Methanandamide-induced Vasorelaxation in Rat Aorta.
EETs/sEH in diabetes and obesity-induced cardiovascular diseases.
Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases.
Effects of myricetin on the bioavailability of carvedilol in rats.
Effects of myricetin, an antioxidant, on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats: possible role of cytochrome P450 3A4, cytochrome P450 2C9 and P-glycoprotein inhibition by myricetin.
Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling.
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy.
Gender Differences in the Impact of CYP2C19 Polymorphisms and Low-Grade Inflammation on Coronary Microvascular Disorder.
Genetic and epigenetic polymorphisms of eNOS and CYP2D6 in mainland Chinese Tibetan, Mongolian, Uygur, and Han populations.
Genetic polymorphism of CYP2D6 in patients with cardiovascular disease -- a cohort study.
Genetic variation in the cytochrome P450 epoxygenase pathway and cardiovascular disease risk.
High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population.
Impact of a variable number tandem repeat in the CYP2C9 promoter on warfarin sensitivity and responsiveness in Jordanians with cardiovascular disease.
In men with erectile dysfunction, satisfaction with quality of erections correlates with erection hardness, treatment satisfaction, and emotional well-being.
Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan.
Inhibition of Mid-chain HETEs Protects Against Angiotensin II-induced Cardiac Hypertrophy.
Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1.
Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases.
Modulation of cardiac cytochrome P450 in patients with heart failure.
Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1.
PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.
Pharmacogenetics of Anticoagulation and Clinical Events in Warfarin-Treated Patients: A Register-Based Cohort Study with Biobank Data and National Health Registries in Finland.
Polymorphisms of cytochrome P450 are potential candidates that could potentially help clinicians on the treatment of cardiovascular diseases among Asian populations.
Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast Cancer.
Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway.
The association of cytochrome P450 1B1 Leu432Val polymorphism with biological markers of health and menopausal symptoms in Slovak midlife women.
The Implication of the Polymorphisms of COX-1, UGT1A6, and CYP2C9 among Cardiovascular Disease (CVD) Patients Treated with Aspirin.
The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease.
The relevance of CYP2D6 genetic polymorphism on chronic metoprolol therapy in cardiovascular patients.
The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins.
Transcriptional Regulation of Drug Metabolizing CYP Enzymes by Proinflammatory Wnt5A Signaling in Human Coronary Artery Endothelial Cells.
[Polymorphisms of genesencoding enzymes of the xenobiotic detoxification system and the risk of infectious endocarditis].
[The most important clinical interactions among medicines used in cardiologic practice]
[The role of genetic polymorphisms of cytochrome P450 in drug metabolism used in the treatment of cardiovascular diseases.]
Catalepsy
Pharmacokinetic factors in sex differences in Delta 9-tetrahydrocannabinol-induced behavioral effects in rats.
Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses.
Cataract
Acetaminophen cytotoxicity in mouse eye: mitochondria in anterior tissues are the primary target.
Acetaminophen produces cataract in DBA2 mice by Ah receptor-independent induction of CYP1A2.
Cataract and the use of statins: a case-control study.
Cataract extraction in patients with primary congenital glaucoma.
Cataract formation by a semiquinone metabolite of acetaminophen in mice: possible involvement of Ca(2+)and calpain activation.
Cerebrotendinous xanthomatosis (CTX): an association of pulverulent cataracts and pseudo-dominant developmental delay in a family with a splice site mutation in CYP27A1--a case report.
Cerebrotendinous xanthomatosis, a metabolic disease with different neurological signs: two case reports.
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review.
Cytotoxic metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, produces cataract in DBA2 mice.
In vivo murine studies on the biochemical mechanism of naphthalene cataractogenesis.
Is cytochrome modulation the new frontier for decreasing the risk of cataract?
NGS-Based Diagnosis of Treatable Neurogenetic Disorders in Adults: Opportunities and Challenges.
Phenotypes of Recessive Pediatric Cataract in a Cohort of Children with Identified Homozygous Gene Mutations (An American Ophthalmological Society Thesis).
Prevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteine.
The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme.
Celiac Disease
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance.
Central Nervous System Diseases
Cytochrome P450 in neurological disease.
Genetic variants of drug metabolizing enzymes and drug transporter (ABCB1) as possible biomarkers for adverse drug reactions in an HIV/AIDS cohort in Zimbabwe.
Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.
[Genetic polymorphism and susceptibility to occupational chronic manganism: a case-control study]
Central Serous Chorioretinopathy
Central serous chorioretinopathy induced by drugs metabolized by cytochrome P450 3A4.
Cerebellar Ataxia
Clinical and genetic characteristics of Chinese patients with cerebrotendinous xanthomatosis.
Cerebral Infarction
CYP1A1 and GSTM1/T1 genetic variation in predicting risk for cerebral infarction.
Interaction between ALOX5AP and CYP3A5 gene variants significantly increases the risk for cerebral infarctions in Chinese.
Cerebral Small Vessel Diseases
Role of soluble epoxide hydrolase in age-related vascular cognitive decline.
Cerebrovascular Disorders
20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease.
Cytochrome P450 2C19 Polymorphism is Associated with Reduced Clopidogrel Response in Cerebrovascular Disease.
Cytochrome P450 eicosanoids in cerebrovascular function and disease.
Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases.
Genetic role of CYP4A11 polymorphisms in the risk of developing cardiovascular and cerebrovascular diseases.
Cervical Intraepithelial Neoplasia
Allelic variations in CYP2D6 gene and susceptibility to cervical cancer.
CYP1A1 gene polymorphism as a risk factor for cervical intraepithelial neoplasia and invasive cervical cancer.
Glutathione-S-transferase M1 and T1 and cytochrome P1A1 genetic polymorphisms and susceptibility to cervical intraepithelial neoplasia in Greek women.
Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking.
Cestode Infections
Fine-Scale Analysis of Parasite Resistance Genes in the Red Flour Beetle, Tribolium castaneum.
Chagas Disease
Antitrypanosomal Activity of Sterol 14?-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain.
Benznidazole and nifurtimox nitroreductase activity in liver microsomes from male rats preinduced with phenobarbital or 3-methylcholanthrene.
Identification of three cytochrome P450 genes in the Chagas' disease vector Triatoma infestans: Expression analysis in deltamethrin susceptible and resistant populations.
Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit.
Chemical and Drug Induced Liver Injury
A prospective study of the incidence of drug-induced liver injury by the modern volatile anaesthetics sevoflurane and desflurane.
Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury.
Association of genetic polymorphisms of CYP2E1, NAT2, GST and SLCO1B1 with the risk of anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis.
Bortezomib alleviates drug-induced liver injury by regulating CYP2E1 gene transcription.
Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats.
Characterization of THLE-CYP Cell Lines, Gene Expression Background and Relationship to CYP-enzyme Activity.
Correlation of CpG Island Methylation of the Cytochrome P450 2E1/2D6 Genes with Liver Injury Induced by Anti-Tuberculosis Drugs: A Nested Case-Control Study.
CYP2E1 and miRNA-378a-3p contribute to acetaminophen or tripterygium glycosides induced hepatotoxicity.
CYP2E1 polymorphism, acetylator profiles and drug-induced liver injury incidence of Indonesian tuberculosis patients.
CYP2E1 RsaI/PstI polymorphism and risk of anti-tuberculosis drug-induced liver injury: a meta-analysis.
CYP2E1, GSTM1, and GSTT1 genetic polymorphisms and their associations with susceptibility to antituberculosis drug-induced liver injury in Thai tuberculosis patients.
Cytochrome P450 2E1 Gene Polymorphisms/Haplotypes and Anti-Tuberculosis Drug-Induced Hepatitis in a Chinese Cohort.
Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis.
Cytochromes P450 and UDP-glucuronosyl-transferases as hepatocellular autoantigens.
Drug Hepatotoxicity: Environmental Factors.
Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver.
Establishment of a primary human hepatocyte spheroid system for evaluating metabolic toxicity using dacarbazine under conditions of CYP1A2 induction.
Formation of reactive metabolites and management of tyrosine kinase inhibitor-induced hepatotoxicity: a literature review.
Genetic and ethnic risk factors associated with drug hypersensitivity.
Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients.
High daily dose and being a substrate of cytochrome P450 enzymes are two important predictors of drug-induced liver injury.
High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model.
Idiosyncratic Drug Induced Liver Injury, Cytochrome P450, Metabolic Risk Factors and Lipophilicity: Highlights and Controversies.
Initial dosage optimization of tacrolimus in Chinese pediatric patients undergoing kidney transplantation based on population pharmacokinetics and pharmacogenetics.
Involvement of cytochrome P450 1A1 and glutathione S-transferase P1 polymorphisms and promoter hypermethylation in the progression of anti-tuberculosis drug-induced liver injury: a case-control study.
In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries.
Lack of association between genetic polymorphisms of CYP3A4, CYP2C9, CYP2C19 and anti-tuberculosis drug-induced liver injury in community-based Chinese population.
Liver physiology and liver diseases in the elderly.
Long-term clinical safety of Clindamycin and Rifampicin combination for the treatment of Hidradenitis suppurativa: a critically appraised topic.
NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis.
Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis.
Polymorphisms of NAT2, CYP2E1, GST, and HLA related to drug-induced liver injury in indonesian tuberculosis patients.
Prediction of Drug-Induced Liver Injury in HepG2 Cells Cultured with Human Liver Microsomes.
Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST.
Role of CYP2E1 immunoglobulin G4 subclass antibodies and complement in pathogenesis of idiosyncratic drug-induced hepatitis.
Role of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment.
Synonymous mutation rs2515641 affects CYP2E1 mRNA and protein expression and susceptibility to drug-induced liver injury.
The association between cytochrome P450 polymorphisms and anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis.
Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.
[Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4]
[Fatal toxic hepatitis in pregnancy. A discussion of the role of methyldopa]
[Pharmacological properties and clinical efficacy of dotinurad (URECE® tablets), a novel hypouricemic agent].
[POLYMORPHISM OF CYP2C9 GENE AND RISK OF HEPATOTOXICITY DEVELOPMENT DURING ANTIRETROVIRAL THERAPY.]
Chikungunya Fever
Molecular cloning and xenobiotic induction of seven novel cytochrome P450 monooxygenases in Aedes albopictus.
Chloracne
Chloracne: a case series on cutaneous expression of CYP1A1 as diagnostic biomarker.
Comparisons of estimated human body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals.
Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with chloracne.
Therapeutic Agents with AHR Inhibiting and NRF2 Activating Activity for Managing Chloracne.
Cholangiocarcinoma
Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma.
Hepatic cytochrome P450 2A6 and 2E1 status in peri-tumor tissues of patients with Opisthorchis viverrini-associated cholangiocarcinoma.
Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450.
Resveratrol enhances the sensitivity of cholangiocarcinoma to chemotherapeutic agents.
Cholera
Expression of the steroidogenic acute regulatory protein mRNA in adrenal tumors and cultured adrenal cells.
Inhibition of basal and stimulated progesterone synthesis by dichlorodiphenyldichloroethylene and methoxychlor in a stable pig granulosa cell line.
Regulation of steroidogenesis in jc-410, a stable cell line of porcine granulosa origin.
[Regulation of aromatase in human choriocarcinoma cells]
Cholestasis
Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling.
Altered Expression of Retinol Metabolism-Related Genes in an ANIT-Induced Cholestasis Rat Model.
Alternative cyclosporine metabolic pathways and toxicity.
Bile acids produce a generalized reduction of the catalytic activity of cytochromes P450 and other hepatic microsomal enzymes in vitro: relevance to drug metabolism in experimental cholestasis.
Chenodeoxycholic acid increases the induction of CYP1A1 in HepG2 and H4IIE cells.
Cholestasis as a dominating symptom of patients with CYP27A1 mutations: An analysis of 17 Chinese infants.
Cholic Acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice.
Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis.
CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid.
Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease.
Downregulation of male-specific cytochrome P450s 2C11 and 3A2 in bile duct-ligated male rats: importance to reduced hepatic content of cytochrome P450 in cholestasis.
Effect of cholestasis produced by bile duct ligation on hepatic heme and hemoprotein metabolism in rats.
Effects of microplastics (MPs) and tributyltin (TBT) alone and in combination on bile acids and gut microbiota crosstalk in mice.
Estrogen-Induced Cholestasis Leads to Repressed CYP2D6 Expression in CYP2D6-Humanized Mice.
Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia.
Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis.
Inhibitory effect of short-term bile duct ligation on hepatic cytochrome P450 of bile acid-depleted rats.
Microsomal and peroxisomal fatty acid oxidation in liver of rats with bile duct ligation and two-thirds hepatectomy.
No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis.
Novel pathways of bile acid metabolism involving CYP3A4.
Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver.
Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis.
Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.
Selective reduction of hepatic cytochrome P450 content in patients with intrahepatic cholestasis. A mechanism for impairment of microsomal drug oxidation.
Severe Neonatal Cholestasis in Cerebrotendinous Xanthomatosis: Genetics, Immunostaining, Mass Spectrometry.
The ileum-liver Farnesoid X Receptor signaling axis mediates the compensatory mechanism of 17?-ethynylestradiol-induced cholestasis via increasing hepatic biosynthesis of chenodeoxycholic acids in rats.
Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes.
[Severe protracted cholestasis after general anesthesia in a patient with Alagille syndrome]
Cholestasis, Intrahepatic
Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis.
Selective reduction of hepatic cytochrome P450 content in patients with intrahepatic cholestasis. A mechanism for impairment of microsomal drug oxidation.
The Interaction of PPAR? and CYP7B1 with ER?, ? Impacted the Occurrence and Development of Intrahepatic Cholestasis in Pregnant Rats.
[Association between CYP1A1 gene polymorphism and intrahepatic cholestasis of pregnancy]
[Association of gene polymorphisms of CYP1B1 with intrahepatic cholestasis of pregnancy]
[Interaction among peroxisome proliferators-activated receptor alpha, cytochrome P450 oxysterol 7?-hydroxylase and estrogen receptor and its association with intrahepatic cholestasis in pregnant rats].
Choline Deficiency
Ethanol and hepatocellular injury.
Chorea
Methylphenidate-Induced Chorea Due to Possible Cytochrome P450 Metabolism Heterogeneity - A Rare Case.
Chorioamnionitis
The anti-inflammatory role of placental Hofbauer cells is altered in patients with chorioamnionitis: Are CYP2C8 and soluble epoxide hydrolase involved in immunomodulation?
Choriocarcinoma
17alpha-methyl testosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like THP-1 cells in culture.
2-(4'-chlorophenyl)benzothiazole is a potent inducer of cytochrome P450IA1 in a human and a mouse cell line. Anomalous correlation between protein and mRNA induction.
Characterization of a region upstream of exon I.1 of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells.
Estrogen synthetase in choriocarcinoma cell culture. Stimulation by dibutyryl cyclic adenosine monophosphate and theophylline.
Estrogen synthetase stimulation by dibutyryl cyclic adenosine 3',5'-monophosphate in human choriocarcinoma cell culture: the relative biosynthetic rate of the nicotinamide adenine dinucleotide phosphate (reduced form)-cytochrome c reductase component.
Estrogen synthetase stimulation by hemin in human choriocarcinoma cell culture.
Identification and characterization of cis-acting regulatory elements for the expression of the human aromatase cytochrome P-450 gene.
Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family.
Macromolecular synthesis is required for stimulation of estrogen synthetase activity by dibutyryl cyclic AMP plus theophylline in choriocarcinoma cell culture.
Regulation by calcium-ion of choriocarcinoma aromatase-activity.
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Relationship between aromatase activity and steroid receptor levels in ovarian tumors from postmenopausal women.
Serotonin and serotonin reuptake inhibitors alter placental aromatase.
Stimulation of serotonergic 5-HT(2A) receptor signaling increases placental aromatase (CYP19) activity and expression in BeWo and JEG-3 human choriocarcinoma cells.
Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells.
WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells.
Choroidal Neovascularization
Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization.
Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization.
Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis.
Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD).
Clonorchiasis
Influencing Factors for Cure of Clonorchiasis by Praziquantel Therapy: Infection Burden and CYP3A5 Gene Polymorphism.
Clostridium Infections
Long-term clinical safety of Clindamycin and Rifampicin combination for the treatment of Hidradenitis suppurativa: a critically appraised topic.
Cocarcinogenesis
Molecular non-genetic biomarkers of effect related to methyl thiophanate cocarcinogenesis: organ- and sex-specific cytochrome P450 induction in the rat.
Coinfection
Clinical and genetic determinants of nevirapine plasma trough concentration.
Co-expression of human cytochrome P4501A1 (CYP1A1) variants and human NADPH-cytochrome P450 reductase in the baculovirus/insect cell system.
Coexpression of cytochrome P4502A6 and human NADPH-P450 oxidoreductase in the baculovirus system.
Comparative study of the effects of anti-tuberculosis drugs and antiretroviral drugs on CYP3A4 and P-glycoprotein.
Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection.
Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily.
Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old.
Establishing Dosing Recommendations for Efavirenz in HIV/TB-Coinfected Children Younger Than 3 Years.
Expression and coupling of human cytochrome P450 2E1 and NADPH-cytochrome P450 oxidoreductase in dual expression and co-infection systems with baculovirus in insect cells.
In vivo phenotyping of cytochrome 450 isoforms involved in the metabolism of anti-HIV and anti-tubercular drugs in human using cocktail approach: An LC-MS/MS analysis.
Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.
Colitis
Decreased drug penetration in inflamed tissue related to changed mucosal metabolism in experimental colitis.
Disturbed bile secretion and cytochrome P450 function during the acute state of experimental colitis in rats.
Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis.
Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine.
Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in the rat model of dextran sulfate sodium-induced experimental colitis.
From the Cover: PhIP/DSS-Induced Colon Carcinogenesis in CYP1A-Humanized Mice and the Possible Role of Lgr5+ Stem Cells.
Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model.
Hepatic early inflammation induces downregulation of hepatic cytochrome P450 expression and metabolic activity in the dextran sulfate sodium-induced murine colitis.
Hepatic flavin-containing monooxygenase gene regulation in different mouse inflammation models.
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Intestinal epithelium-specific knockout of the cytochrome P450 reductase gene exacerbates dextran sulfate sodium-induced colitis.
Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis.
Review article: the potential mechanisms of action of rifaximin in the management of inflammatory bowel diseases.
Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions.
TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease.
Colitis, Ulcerative
ATP-binding cassette subfamily B member 1 1236C/T polymorphism significantly affects the therapeutic outcome of tacrolimus in patients with refractory ulcerative colitis.
Changes in the Pharmacokinetics of Phenytoin in Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.
CYP3A5 genetic polymorphisms affect the pharmacokinetics and short-term remission in patients with ulcerative colitis treated with tacrolimus.
CYP3A5 Genotype as a Potential Pharmacodynamic Biomarker for Tacrolimus Therapy in Ulcerative Colitis in Japanese Patients.
Cytochrome P450 (CYP450,2D6*A), N-Acetyltransferase-2 (NAT2*7, A) and Multidrug Resistance 1 (MDR1 3435 T) Alleles Collectively Increase Risk of Ulcerative Colitis.
Expression of hepatic cytochrome P450 in a mouse model of ulcerative colitis changes with pathological conditions.
Expression of selected cytochrome P450 isoforms and of cooperating enzymes in colorectal tissues in selected pathological conditions.
How autophagy controls the intestinal epithelial barrier.
Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis.
Polymorphism in the Retinoic Acid Metabolizing Enzyme CYP26B1 and the Development of Crohn's Disease.
Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism.
Relationship between CYP2A6 genetic polymorphism, as a marker of nicotine metabolism, and ulcerative colitis.
Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis.
Serum derived from ulcerative colitis mouse changes the metabolism of the fluorescent substrate by P450 depending on the degree of disease progression.
Tacrolimus Dose Optimization Strategy for Refractory Ulcerative Colitis Based on the Cytochrome P450 3A5 Polymorphism Prediction Using Trough Concentration after 24 Hours.
The effect of CYP3A5 genetic polymorphisms on adverse events in patients with ulcerative colitis treated with tacrolimus.
The impact of cytochrome P450 3A genetic polymorphisms on tacrolimus pharmacokinetics in ulcerative colitis patients.
Coloboma
Cyp1b1 Regulates Ocular Fissure Closure Through a Retinoic Acid-Independent Pathway.
Ultra-rare renal diseases diagnosed with whole-exome sequencing: Utility in diagnosis and management.
Colonic Neoplasms
3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease.
Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes.
Association between CYP24A1 polymorphisms and the risk of colonic polyps and colon cancer in a Chinese population.
Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins.
Colonic vitamin D metabolism: Implications for the pathogenesis of inflammatory bowel disease and colorectal cancer.
CYP1A1, cigarette smoking, and colon and rectal cancer.
CYP24A1 and CYP27B1 Polymorphisms Modulate Vitamin D Metabolism in Colon Cancer Cells.
CYP24A1 splice variants-Implications for the antitumorigenic actions of 1,25-(OH)(2)D(3) in colorectal cancer.
CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.
Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development.
Debrisoquine hydroxylase gene polymorphism in meningioma.
Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis.
Duodenal 7-ethoxycoumarin-o-deethylase activity in colon-cancer patients.
Effect of butyrate on aromatase cytochrome P450 levels in HT29, DLD-1 and LoVo colon cancer cells.
Effect of chronic dietary ethanol consumption on colonic cancer in rats induced by 1,1-dimethylhydrazine.
Effect of cytochrome P450 inducers on expression of oncogenes and a tumor suppressor gene in human colon cancer cells.
Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells.
Effects of diet and ethanol on the expression and localization of cytochromes P450 2E1 and P450 2C7 in the colon of male rats.
Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats.
Epigenetic regulation of the 1,25-dihydroxyvitamin D(3) 24-hydroxylase (CYP24A1) in colon cancer cells.
Estrogen synthesis in human colon cancer epithelial cells.
Expression of CYP and GST in human normal and colon tumor tissues.
Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur.
Expression of VDR and CYP24A1 mRNA in human tumors.
Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study.
Fractionation of polyphenol-enriched apple juice extracts to identify constituents with cancer chemopreventive potential.
Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells.
Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population.
Genetic polymorphisms in the cytochrome P450 1A1, glutathione S-transferase M1 and T1, and susceptibility to colon cancer.
Genetic Predictors of Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer.
Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: Colon cancer family registry.
Genistein affects expression of cytochrome P450 (CYP450) genes in hepatocellular carcinoma (HEPG2/C3A) cell line.
Human cytochrome P4501A2.
Hydroxylated Chalcones as Aryl Hydrocarbon Receptor Agonists: Structure-Activity Effects.
Identification and clinical validation of metastasis-associated biomarkers based on large-scale samples in colon-adenocarcinoma.
Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: comparison of carcinogenicity and aryl hydrocarbon hydroxylase induction in the target organs of each species.
Innovational combination of hetero-bifunctional N-PEG quinoline scaffolds derivatives with improved anticancer activity against breast and colon cancer cell lines and P-glycoprotein, cytochrome p450 enzyme activity prediction.
Intestinal bacterium-derived cyp27a1 prevents colon cancer cell apoptosis.
Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships.
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4.
Molecular cloning of the guinea pig CYP1A2 gene 5'-flanking region: identification of functional aromatic hydrocarbon response element and characterization of CYP1A2 expression in GPC16 cells.
Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells.
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Polymorphisms in drug-metabolizing enzymes as modifiers of cancer risk.
Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24.
Role of acetylation in colorectal cancer.
Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers.
Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavones.
Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis.
Ten polymorphisms of estrogen-metabolizing genes and a family history of colon cancer--an association study of multiple gene-gene interactions.
The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol.
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.
Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk.
[Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro].
[Genetic polymorphism in cytochrome P450 2E1, salted food and colorectal cancer susceptibility: a case-control study]
[Genetic polymorphisms in xenobiotic metabolizing enzymes as a determinant of susceptibility to environmental mutagens and carcinogens in humans]
Colorectal Neoplasms
5-Fluorouracil prodrug: role of anabolic and catabolic pathway modulation in therapy of colorectal cancer.
A candidate intronic CYP24A1 gene variant affects the risk of colorectal cancer.
A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer.
A novel circular RNA hsa_circ_0060927 may serve as a potential diagnostic biomarker for human colorectal cancer.
A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population.
A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.
A Phase II study of clinical outcomes of 3-week cycles of irinotecan and S-1 in patients with previously untreated metastatic colorectal cancer: influence of the UGT1A1 and CYP2A6 polymorphisms on clinical activity.
A prospective study of cytochrome P450 1A1 polymorphisms and colorectal cancer risk in men.
A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on markers of their metabolism in normal mucosa of colorectal adenoma patients.
Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8.
Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene rs11572080 with Regard to Colorectal Cancer Risk.
Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk.
Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary.
Association between CYP1A1 2454A > G polymorphism and colorectal cancer risk: A meta-analysis.
Association between CYP1A1 polymorphism and colorectal cancer risk: a meta-analysis.
Association between CYP1A2 and CYP1B1 polymorphisms and colorectal cancer risk: a meta-analysis.
Association between cytochrome P450 2C9 gene polymorphisms and colorectal cancer susceptibility: evidence from 16 case-control studies.
Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: A hospital-based case-control study in Japan.
Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population.
Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan.
Association of CYP1A1, CYP1A2, GSTM1 and NAT2 Gene Polymorphisms with Colorectal Cancer and Smoking.
Association of CYP24A1 gene polymorphism with colorectal cancer in the Jiamusi population.
Association of CYP2C9 genotypes leading to high enzyme activity and colorectal cancer risk.
Association of GSTM1, GSTT1, GSTP1 and CYP2E1 Single Nucleotide Polymorphisms with Colorectal Cancer in Iran.
Associations between CYP1A1 rs1048943 A > G and rs4646903 T > C genetic variations and colorectal cancer risk: Proof from 26 case-control studies.
Associations of CYP2E1 rs2031920 and rs3813867 polymorphisms with colorectal cancer risk: a systemic review and meta-analysis.
Bi-functional induction of the quinone reductase and cytochrome P450 1A1 by youngiasides via Nrf2-ARE and AhR-XRE pathways.
Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer.
Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.
Coexistence of copy number increases of ZNF217 and CYP24A1 in colorectal cancers in a Chinese population.
Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-Results from the EPIC cohort study.
Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland.
Colorectal cancer risk in relation to genetic polymorphism of cytochrome P450 1A1, 2E1, and glutathione-S-transferase M1 enzymes.
Colorectal cancer specific cytochrome P450 2W1 (CYP2W1): intracellular localization, glycosylation, and catalytic activity.
Combinations of cytochrome P450 gene polymorphisms enhancing the risk for sporadic colorectal cancer related to red meat consumption.
Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk.
CYP1A1 genetic polymorphisms and in situ colorectal cancer.
CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients.
CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: A meta-analysis.
CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma.
CYP1A1, cigarette smoking, and colon and rectal cancer.
CYP1B1 Asn453Ser polymorphism and colorectal cancer risk: a meta-analysis.
CYP1B1 Leu432Val polymorphism and colorectal cancer risk among Caucasians: a meta-analysis.
CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers.
CYP24A1 and CYP27B1 Polymorphisms Modulate Vitamin D Metabolism in Colon Cancer Cells.
CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells.
CYP24A1 Inhibition Facilitates the Antiproliferative Effect of 1,25(OH)2D3 Through Downregulation of the WNT/?-Catenin Pathway and Methylation-Mediated Regulation of CYP24A1 in Colorectal Cancer Cells.
CYP24A1 is a potential biomarker for the progression and prognosis of human colorectal cancer.
CYP24A1 splice variants-Implications for the antitumorigenic actions of 1,25-(OH)(2)D(3) in colorectal cancer.
CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk.
CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.
CYP2D6 metabolism and patient outcome in the Austrian Breast and Colorectal Cancer Study Group trial (ABCSG) 8.
CYP2E1 polymorphisms and colorectal cancer risk: a HuGE systematic review and meta-analysis.
CYP2E1 PstI/RsaI polymorphism and colorectal cancer risk: a meta-analysis.
CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.
CYP2E1 RsaI and 96-bp insertion genetic polymorphisms associated with risk for colorectal cancer.
CYP2E1 T7632A and 9-bp insertion polymorphisms and colorectal cancer risk: a meta-analysis based on 4,592 cases and 5,918 controls.
CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648) sensitivity in breast and colorectal cancer cells.
CYP2S1 gene polymorphisms in a Korean population.
Cytochrome P450 1A1, 2E1 and GSTM1 gene polymorphisms and susceptibility to colorectal cancer in the Saudi population.
Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development.
Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers.
Cytochrome P450 content in primary tumors and liver metastases of patients with metastatic colorectal cancer.
Cytochrome P450 monooxygenase/soluble epoxide hydrolase-mediated eicosanoid pathway in colorectal cancer and obesity-associated colorectal cancer.
Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Design, Synthesis, and Biological Evaluation of Cytochrome P450 1B1 Targeted Molecular Imaging Probes for Colorectal Tumor Detection.
Detection of cytochrome P450 1B1 Bfr I polymorphism: genotype distribution in healthy German individuals and in patients with colorectal carcinoma.
Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean population.
Dysregulation of vitamin D synthesis pathway genes in colorectal cancer: A case-control study.
Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans.
Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention against colorectal tumors in single Japanese cohort using daily low-dose aspirin: insights into future personalized treatments.
Epigenetic regulation of the 1,25-dihydroxyvitamin D(3) 24-hydroxylase (CYP24A1) in colon cancer cells.
Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study.
Estrogen synthesis in human colon cancer epithelial cells.
Evaluation of Lynch syndrome modifier genes in 748 MMR mutation carriers.
Exploratory Genome-Wide Interaction Analysis of Nonsteroidal Anti-inflammatory Drugs and Predicted Gene Expression on Colorectal Cancer Risk.
Expression of CYP1B1 and B7-H3 significantly correlates with poor prognosis in colorectal cancer patients.
Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy.
Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study.
Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling.
Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines.
Genetic polymorphism in cytochrome P450 7A1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.
Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer.
Genetic polymorphism of xenobiotic metabolising enzymes, diet and cancer susceptibility.
Genetic polymorphisms in cytochrome P450 and clinical outcomes of FOLFIRI chemotherapy in patients with metastatic colorectal cancer.
Genetic polymorphisms of CYP2E1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.
Genetic polymorphisms of vitamin D metabolism genes and serum level of vitamin D in colorectal cancer.
Genetic polymorphisms of vitamin D receptor (VDR), CYP27B1 and CYP24A1 genes and the risk of colorectal cancer.
Genetic Predictors of Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer.
Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients.
Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome.
Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: Colon cancer family registry.
Genetic Variations in the Xenobiotic-Metabolizing Enzymes CYP1A1, CYP1A2, CYP2C9, CYP2C19 and Susceptibility to Colorectal Cancer Among Turkish People.
Genotyping of CYP3A5 polymorphisms among Bulgarian patients with sporadic colorectal cancer and controls.
Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population.
How autophagy controls the intestinal epithelial barrier.
Impact of CYP24A1 overexpression on growth of colorectal tumour xenografts in mice fed with vitamin D and soy.
Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer.
Indole-3-carbinol induces tumor cell death: function follows form.
Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans.
Inhibitory Effect of 5-Fluorouracil on Cytochrome P450 2C9 Activity in Cancer Patients.
Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention.
Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3.
Keratinocyte Growth Factor Regulation of Aryl Hydrocarbon Receptor Activation in Colorectal Cancer Cells.
Meta-analysis of association studies of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese.
Meta-analysis of cytochrome P-450 2C9 polymorphism and colorectal cancer risk.
Metabolic genotypes and risk for colorectal cancer.
miR-30a promoter variation contributes to the increased risk of colorectal cancer in an Iranian population.
No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma.
No modification of the beneficial effect of NSAIDs on colorectal cancer by CYP2C9 genotype.
Novel long noncoding RNAs upregulation may have synergistic effects on the CYP24A1 and PFDN4 biomarker role in human colorectal cancer.
Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer.
Overexpression of CYP2A6 in human colorectal tumors.
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Phenotypic CYP2A6 variation and the risk of pancreatic cancer.
Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.
Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.
Polymorphisms of cytochrome P450 1A2 and N-acetyltransferase genes, meat consumption, and risk of colorectal cancer.
Potential of Teucrium chamaedrys L. to modulate apoptosis and biotransformation in colorectal carcinoma cells.
PPAR? plays an important role in the migration activity, and the expression of CYP2S1 and CYP1B1 in chrysin-treated HCT116 cells.
Prediction of Early Recurrence After Curative Resection of Colorectal Liver Metastasis and Subsequent S-1 Chemotherapy.
Quantitative assessment of the effect of cytochrome P450 2C9 gene polymorphism and colorectal cancer.
Quantitative Assessment of the Influence of Cytochrome P450 1A2 Gene Polymorphism and Colorectal Cancer Risk.
Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps.
Red meat intake, CYP2E1 and PPAR? polymorphisms, and colorectal cancer risk.
Red meat intake, CYP2E1 genetic polymorphisms, and colorectal cancer risk.
Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.
Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in colorectal cancer.
Relationship between metabolic enzyme polymorphism and colorectal cancer.
Relative Expression of Vitamin D Hydroxylases, CYP27B1 and CYP24A1, and of Cyclooxygenase-2 and Heterogeneity of Human Colorectal Cancer in Relation to Age, Gender, Tumor Location, and Malignancy: Results from Factor and Cluster Analysis.
Role of acetylation in colorectal cancer.
Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population.
Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer.
The association of CYP2C9 gene polymorphisms with colorectal carcinoma in Han Chinese.
The CYP1A1 genotype may alter the association of meat consumption patterns and preparation with the risk of colorectal cancer in men and women.
The expression of CYP2W1 in colorectal primary tumors, corresponding lymph node metastases and liver metastases.
The expression of CYP2W1: a prognostic marker in colon cancer.
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
Toxicological aspects of flavonoid interaction with biomacromolecules.
Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer.
Using a combination of cytochrome P450 1B1 and beta-catenin for early diagnosis and prevention of colorectal cancer.
Variant alleles of the CYP1B1 gene are associated with colorectal cancer susceptibility.
[Association between genetic polymorphisms of metabolic enzymes and susceptibility of colorectal cancer]
[Genetic polymorphism in cytochrome P450 2E1, salted food and colorectal cancer susceptibility: a case-control study]
[Validation of genetic polymorphisms associated to the toxicity of chemotherapy in colorectal cancer patients].
Colorectal Neoplasms, Hereditary Nonpolyposis
Evaluation of Lynch syndrome modifier genes in 748 MMR mutation carriers.
Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome.
Polymorphisms of xenobiotic-metabolizing genes and colorectal cancer risk in patients with lynch syndrome: A retrospective cohort study in Taiwan.
Coma
Dosing Recommendations for Quetiapine When Coadministered With HIV Protease Inhibitors.
Factors Predisposing to Coma and Delirium: Fentanyl and Midazolam Exposure; CYP3A5, ABCB1, and ABCG2 Genetic Polymorphisms; and Inflammatory Factors*.
[Disorders of olfactory function in penetrating head injuries sustained during war]
Communicable Diseases
African variation at Cytochrome P450 genes: Evolutionary aspects and the implications for the treatment of infectious diseases.
HepaRG cells as human-relevant in vitro model to study the effects of inflammatory stimuli on cytochrome P450 isoenzymes.
Mechanism of hepatic cytochrome P450 modulation during Listeria monocytogenes infection in mice.
Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.
Modulatory effect of hyperthermia on hepatic microsomal cytochrome P450 in mice.
Regulation of drug metabolism and disposition during inflammation and infection.
Whole Exome Sequencing Among 26 Patients With Indeterminate Acute Liver Failure: A Pilot Study.
[Effects of rifampicin on the pharmacodynamics of doxycycline]
Confusion
CYP2D6 genotype predicts tamoxifen discontinuation and drug response: a secondary analysis of the KARISMA trial.
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver.
Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group.
Congenital Abnormalities
AHR-related activities in a creosote-adapted population of adult atlantic killifish, Fundulus heteroclitus, two decades post-EPA superfund status at the Atlantic Wood Site, Portsmouth, VA USA.
AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos.
AHR2-Mediated Transcriptomic Responses Underlying the Synergistic Cardiac Developmental Toxicity of PAHs.
Application of molecular endpoints in early life stage salmonid environmental biomonitoring.
Characterization of the recalcitrant CYP1 phenotype found in Atlantic killifish (Fundulus heteroclitus) inhabiting a Superfund site on the Elizabeth River, VA.
CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio).
Developmental and latent effects of diluted bitumen exposure on early life stages of sockeye salmon (Oncorhynchus nerka).
DNA damage and health effects in juvenile haddock (Melanogrammus aeglefinus) exposed to PAHs associated with oil-polluted sediment or produced water.
Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities.
Environmental concentrations of benz[a]anthracene induce developmental defects and DNA damage and impair photomotor response in Japanese medaka larvae.
Evaluation of environmental impact on natural populations of the Mediterranean killifish Aphanius fasciatus by quantitative RNA biomarkers.
For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.
Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction.
Is oxidative stress the mechanism of blue sac disease in retene-exposed trout larvae?
Persistent effects on adult swim performance and energetics in zebrafish developmentally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Phenotypic anchoring of gene expression after developmental exposure to aryl hydrocarbon receptor ligands in zebrafish.
Polluted-site killifish (Fundulus heteroclitus) embryos are resistant to organic pollutant-mediated induction of CYP1A activity, reactive oxygen species, and heart deformities.
Relationship between low midazolam metabolism by cytochrome P450 3A in mice and the high incidence of birth defects.
Resistance to polycyclic aromatic hydrocarbon toxicity and associated bioenergetic consequences in a population of Fundulus heteroclitus.
Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus.
Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish.
Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors.
Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in developing red seabream (Pagrus major) embryo: an association of morphological deformities with AHR1, AHR2 and CYP1A expressions.
Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists.
Congenital Microtia
Identification of a novel CYP26A1 mutation in a Chinese family with congenital microtia.
Conjunctivitis, Allergic
Ritonavir and Topical Ocular Corticosteroid Induced Cushing's Syndrome in an Adolescent with HIV-1 Infection.
Connective Tissue Diseases
Effect of CYP3A5 and ABCB1 polymorphisms on the interaction between tacrolimus and itraconazole in patients with connective tissue disease.
Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases.
Corneal Diseases
Genetics of Congenital Corneal Opacification-Impact on Diagnosis and Treatment.
Corneal Injuries
Corneal damage and lacrimal gland dysfunction in a smoking rat model.
Corneal Neovascularization
Inhibition of VEGF expression and corneal neovascularization by siRNA targeting cytochrome P450 4B1.
Corneal Opacity
CYP1B1-Related Anterior Segment Developmental Anomalies Novel Mutations for Infantile Glaucoma and Von Hippel's Ulcer Revisited.
Corneal Ulcer
CYP1B1 Cytopathy: Uncommon Phenotype of a Homozygous CYP1B1 Deletion as Internal Corneal Ulcer of Von Hippel.
Coronary Artery Disease
?2A-Adrenergic Receptor Polymorphism Potentiates Platelet Reactivity in Patients With Stable Coronary Artery Disease Carrying the Cytochrome P450 2C19*2 Genetic Variant.
Are the T/C polymorphism of the CYP17 gene and the tetranucleotide repeat (TTTA) polymorphism of the CYP19 gene genetic markers for premature coronary artery disease in Caucasians?
Association between cytochrome P450 2C19 polymorphism and clinical outcomes in Chinese patients with coronary artery disease.
Association of CYP2C19, CYP3A5 and GPIIb/IIIa gene polymorphisms with Aspirin and Clopidogrel Resistance in a cohort of Indian patients with Coronary Artery Disease.
Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease.
Caffeine intake reduces incident atrial fibrillation at a population level.
CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation.
CYP2D6 (C2850T, G1846A, C100T) polymorphisms, haplotypes and MDR analysis in predicting coronary artery disease risk in north-west Indian population: A case-control study.
Cytochrome P450 2C19 Polymorphism in Iranian Patients with Coronary Artery Disease.
Cytochrome P450 2C19 polymorphism is associated with poor clinical outcomes in coronary artery disease patients treated with clopidogrel.
Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease.
Cytochrome P450 genes in coronary artery diseases: Codon usage analysis reveals genomic GC adaptation.
Cytochrome P450-derived eicosanoids and vascular dysfunction in coronary artery disease patients.
Cytochrome P450-derived epoxyeicosatrienoic acids and coronary artery disease in humans: a targeted metabolomics study.
Diplotypes of CYP2C9 gene is associated with coronary artery disease in the Xinjiang Han population for women in China.
Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.
Effects of cytochrome P450 2C19 and paraoxonase 1 polymorphisms on antiplatelet response to clopidogrel therapy in patients with coronary artery disease.
Erratum to: The association between CYP1A1 genetic polymorphisms and coronary artery disease in the Uygur and Han of China.
Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease.
Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients.
Gene-gene interaction between PPARG and CYP1A1 gene on coronary artery disease in the Chinese Han Population.
Genetic influence on cigarette-induced cardiovascular disease.
Genetic polymorphisms of the CYP1A1, GSTM1, and GSTT1 enzymes and their influence on cardiovascular risk and lipid profile in people who live near a natural gas plant.
GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smoking-related coronary artery disease: a case-only study.
Impact of CYP2C8 and 2C9 polymorphisms on coronary artery disease and myocardial infarction in the LURIC cohort.
Impact of CYP3A5 polymorphism on platelet reactivity at percutaneous coronary intervention and after 9 months of aspirin and clopidogrel therapy in Japanese patients with coronary artery disease.
Impact of Genetic Variations of the CYP1A1, GSTT1, and GSTM1 Genes on the Risk of Coronary Artery Disease.
Impact of interaction between CYP1A1 genetic polymorphisms and smoking on coronary artery disease in the Han of China.
Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease.
Interactions Networks for Primary Heart Sarcomas.
Lack of association between CYP1A1 T6235C polymorphism and coronary artery disease: evidence from a meta-analysis.
Meta-Analysis of Cytochrome P450 2C19 Polymorphism and Risk of Adverse Clinical Outcomes Among Coronary Artery Disease Patients of Different Ethnic Groups Treated With Clopidogrel.
Mutation in CYP27A1 identified in family with coronary artery disease.
Polymorphism rs2762939 of CYP24A1 enzyme and coronary artery disease: angiographic results from a large prospective cohort of patients.
Polymorphisms of cytochrome P450 1A1, cigarette smoking and risk of coronary artery disease.
Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking.
Relationship between cytochrome P450 2C19*17 genotype distribution, platelet aggregation and bleeding risk in patients with blood stasis syndrome of coronary artery disease treated with clopidogrel.
Relationship between rs4674344 CYP27A1 gene polymorphism and coronary artery disease in a Polish population.
Response to clopidogrel and of the cytochrome CYP2C19 gene polymorphism.
Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.
Role of CYP1A1 haplotypes in modulating susceptibility to coronary artery disease.
Simvastatin intolerance genetic determinants: some features in ethnic Uzbek patients with coronary artery disease.
Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis.
The association between CYP1A1 genetic polymorphisms and coronary artery disease in the Uygur and Han of China.
The CYP2C19 genotype does not impact the long-term prognosis of patients with coronary artery disease.
[Association analysis of gene polymorphism in alcohol metabolizing enzymes with risk for coronary atherosclerosis]
[Association between CYP1A1 genetic polymorphisms and coronary artery disease in Uygur population in Xinjiang, China].
[Association of the MspI polymorphism of cytochrome P4501A1 gene and smoking to the susceptibility to coronary artery disease]
[Relationship between ATP-binding cassette subfamily B member 1 and cytochrome P450 2C19 polymorphisms and the effect of clopidogrel post percutaneous coronary intervention in patients with acute coronary syndrome].
Coronary Disease
Association between CYP2C19*2/*3 Polymorphisms and Coronary Heart Disease.
Association of cytochrome P450 2C19 polymorphisms with coronary heart disease risk: A protocol for systematic review and meta analysis.
Contribution of CYP24A1 variants in coronary heart disease among the Chinese population.
CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndromes patients.
CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.
Cytochrome P450 2C19*2 polymorphism in patients with stable coronary heart disease and risk for secondary cardiovascular disease events: results of a long-term follow-up study in routine clinical care.
Diversity of platelet function and genetic polymorphism in clopidogrel-treated Chinese patients.
Effect of Cytochrome P450 Family 2 Subfamily R Member 1 Variants on the Predisposition of Coronary Heart Disease in the Chinese Han Population.
Genotype Frequencies of CYP2C19, P2Y12 and GPIIIa Polymorphisms in Coronary Heart Disease Patients of Han Ethnicity, and Their Impact on Clopidogrel Responsiveness.
Identification of a CYP19 Gene Single-Nucleotide Polymorphism Associated with a Reduced Risk of Coronary Heart Disease.
Pharmacogenetic testing by polymorphic markers G1846A (CYP2D6*4) and C100T (CYP2D6*10) of the CYP2D6 gene in coronary heart disease patients taking ??-blockers in the Republic of Sakha (YAKUTIA).
Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population.
Role of CYP1A1 (T6235C) polymorphism and cigarette smoking in the development of coronary heart disease in Tunisian population.
The association study between CYP20A1, CYP4F2, CYP2D6 gene polymorphisms and coronary heart disease risk in the Han population in southern China.
Coronary Stenosis
Effects of epoxyeicosatrienoic acids on polymorphonuclear leukocyte function.
Cough
Analysis of dextrorphan, a metabolite of dextromethorphan, using gas chromatography with electron-capture detection.
Effects of Ephedra Water Decoction and Cough Tablets containing Ephedra and Liquorice on CYP1A2 and the Pharmacokinetics of Theophylline in Rats.
Ephedra water decoction and cough tablets containing ephedra and liquorice induce CYP1A2 but not CYP2E1 hepatic enzymes in rats.
The antitussive effect of dextromethorphan in relation to CYP2D6 activity.
COVID-19
Clinically Significant Drug Interactions Between Psychotropic Agents and Repurposed COVID-19 Therapies.
CYP2D6 and CYP3A4 variants influence the risk and outcome of COVID-19 infection among rheumatoid arthritis patients maintained on hydroxychloroquine.
Drug Interactions of Psychiatric and COVID-19 Medications.
Drug-drug interactions between COVID-19 treatments and antipsychotics drugs: integrated evidence from 4 databases and a systematic review.
First-Degree Atrioventricular Block with Tachycardia from Paliperidone and Mirtazapine Overdose.
Genetic Polymorphisms Complicate COVID-19 Therapy: Pivotal Role of HO-1 in Cytokine Storm.
Impact of SARS-CoV-2 Infection (COVID-19) on Cytochromes P450 Activity Assessed by the Geneva Cocktail.
Pharmacogenetics Approach for the Improvement of COVID-19 Treatment.
Craniocerebral Trauma
Head injury and cytochrome P-450 enzymes. Differential effect on mRNA and protein expression in the Fischer-344 rat.
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration.
Craniofacial Abnormalities
Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations.
Craniosynostoses
Akhenaten and the strange physiques of Egypt's 18th dynasty.
Crohn Disease
Genetic polymorphisms in biotransformation enzymes in Crohn's disease: association with microsomal epoxide hydrolase.
How autophagy controls the intestinal epithelial barrier.
Iatrogenic cushing syndrome secondary to a probable interaction between voriconazole and budesonide.
Iatrogenic Cushing's syndrome related to the interaction between oral budesonide with fluvoxamine: a case report.
Polymorphism in the Retinoic Acid Metabolizing Enzyme CYP26B1 and the Development of Crohn's Disease.
Cryptococcosis
In Silico Structural Modeling and Analysis of Interactions of Tremellomycetes Cytochrome P450 Monooxygenases CYP51s with Substrates and Azoles.
Cryptorchidism
Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias.
Expression of anti-Müllerian hormone, CDKN1B, connexin 43, androgen receptor and steroidogenic enzymes in the equine cryptorchid testis.
Cushing Syndrome
Adrenal Insufficiency With Voriconazole and Inhaled/Intranasal Corticosteroids: Case Report and Systematic Review.
Aminoglutethimide suppresses adrenocorticotropin receptor expression in the NCI-h295 adrenocortical tumor cell line.
Cushing syndrome and severe adrenal suppression caused by fluticasone and protease inhibitor combination in an HIV-infected adolescent.
Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men.
Fluticasone furoate induced iatrogenic Cushing syndrome in a pediatric patient receiving anti-retroviral therapy.
Iatrogenic Cushing syndrome due to drug interaction between inhaled fluticasone and cobicistat.
Iatrogenic Cushing Syndrome from Interaction Between Ritonavir and Oral Budesonide During Direct Acting Antiviral Hepatitis C Therapy.
Iatrogenic Cushing's syndrome related to the interaction between oral budesonide with fluvoxamine: a case report.
Inhalational Steroids and Iatrogenic Cushing's Syndrome.
Inhaled budesonide induced Cushing's syndrome in cystic fibrosis patients, due to drug inhibition of cytochrome P450.
Preventing Cushing: Iatrogenic Cushing Syndrome due to Ritonavir-Fluticasone Interaction.
Ritonavir and Topical Ocular Corticosteroid Induced Cushing's Syndrome in an Adolescent with HIV-1 Infection.
Cystic Fibrosis
Activities of cytochrome P450 1A2, N-acetyltransferase 2, xanthine oxidase, and cytochrome P450 2D6 are unaltered in children with cystic fibrosis.
An unusual cause of growth failure in cystic fibrosis: A salutary reminder of the interaction between glucocorticoids and cytochrome P450 inhibiting medication.
Caffeine metabolism in cystic fibrosis: enhanced xanthine oxidase activity.
CYP2D6, N-acetylation, and xanthine oxidase activity in cystic fibrosis.
Cystic fibrosis: a casualty of "detoxification"?
Cytochrome P450 3A4 induction: lumacaftor versus ivacaftor potentially resulting in significantly reduced plasma concentration of ivacaftor.
Disposition of drugs in cystic fibrosis. V. In vivo CYP2C9 activity as probed by (S)-warfarin is not enhanced in cystic fibrosis.
Disposition of drugs in cystic fibrosis. VI. In vivo activity of cytochrome P450 isoforms involved in the metabolism of (R)-warfarin (including P450 3A4) is not enhanced in cystic fibrosis.
Effect of cytochrome P450 2C19 genotype on voriconazole exposure in cystic fibrosis lung transplant patients.
Enhanced drug metabolism in young children with cystic fibrosis.
Hepatic drug clearance in patients with mild cystic fibrosis.
How autophagy controls the intestinal epithelial barrier.
Impact of CYP3A5 phenotype on tacrolimus concentrations after sublingual and oral administration in lung transplant.
Inhaled budesonide induced Cushing's syndrome in cystic fibrosis patients, due to drug inhibition of cytochrome P450.
Pharmacokinetic interactions between ivacaftor and cytochrome P450 3A4 inhibitors in people with cystic fibrosis and healthy controls.
Population pharmacokinetic modelling and design of a bayesian estimator for therapeutic drug monitoring of tacrolimus in lung transplantation.
[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]
Cystinuria
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
[Molecular and genetic technologies for the diagnosis of monogenic forms of urinary stone disease: clinical cases].
Cystitis
Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6.
The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation.
Cystitis, Interstitial
Differentiation associated changes in gene expression profiles of interstitial cystitis and control urothelial cells.
Cysts
Altered vitamin D metabolic system in follicular cysts of sows.
CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women.
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
RASopathic comedo-like or cystic lesions induced by Vemurafenib: A model of skin lesions similar but not identical to those induced by dioxins (MADISH).
Spatially heterogeneous expression of aromatase P450 through promoter II is closely correlated with the level of steroidogenic factor-1 transcript in endometrioma tissues.
Supraphysiological leptin levels shift the profile of steroidogenesis in porcine ovarian follicles toward progesterone and testosterone secretion through increased expressions of CYP11A1 and 17?-HSD: a tissue culture approach.
The human Ah receptor: hints from dioxin toxicities to deregulated target genes and physiologic functions.
Dandruff
Cloning and Expression in Pichia pastoris of a New Cytochrome P450 Gene from a Dandruff-causing Malassezia globosa.
Death, Sudden, Cardiac
Advantages of azithromycin over erythromycin in improving the gastric emptying half-time in adult patients with gastroparesis.
Dehydration
Alteration of P450 distal pocket solvent leads to impaired proton delivery and changes in heme geometry.
Dehydration of alkyl- and arylaldoximes as a new cytochrome P450-catalyzed reaction: mechanism and stereochemical characteristics.
Effects of glucose supplementation on the pharmacokinetics of intravenous chlorzoxazone in rats with water deprivation for 72 h.
Effects of water deprivation on drug pharmacokinetics: correlation between drug metabolism and hepatic CYP isozymes.
Effects of water deprivation on the pharmacokinetics of metformin in rats.
Elicitor-induced association of isoflavone O-methyltransferase with endomembranes prevents the formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis.
Fatty acid dioxygenase-cytochrome P450 fusion enzymes of filamentous fungal pathogens.
Fatty acid dioxygenase-cytochrome P450 fusion enzymes of the top 10 fungal pathogens in molecular plant pathology and human-pathogenic fungi.
Identification of genes associated with stress tolerance in moth bean [Vigna aconitifolia (Jacq.) Marechal], a stress hardy crop.
Lidocaine elimination and monoethylglycinexylidide formation in the dehydrated camel.
Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs.
Pharmacokinetics of intravenous chlorzoxazone in rats with dehydration and rehydration: effects of food intakes.
Delirium
Delirium in a patient with toxic flecainide plasma concentrations: the role of a pharmacokinetic drug interaction with paroxetine.
Delirium probably induced by clarithromycin in a patient receiving fluoxetine.
Delirium resolving upon switching from risperidone to quetiapine: implication of CYP2D6 genotype.
Dextromethorphan-induced delirium and possible methadone interaction.
Factors Predisposing to Coma and Delirium: Fentanyl and Midazolam Exposure; CYP3A5, ABCB1, and ABCG2 Genetic Polymorphisms; and Inflammatory Factors*.
Prolonged anticholinergic delirium following antihistamine overdose.
Dementia
Alzheimer's disease: beware of interactions with cholinesterase inhibitors.
Clinical Response to Donepezil in Mild and Moderate Dementia: Relationship to Drug Plasma Concentration and CYP2D6 and APOE Genetic Polymorphisms.
CYP2D6 gene polymorphism as a probable risk factor for Alzheimer's disease and Parkinson's disease with dementia.
CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease.
CYP2D6 polymorphisms in Alzheimer's disease, with and without extrapyramidal signs, showing no apolipoprotein E epsilon 4 effect modification.
CYP2D6 Predicts Plasma Donepezil Concentrations in a Cohort of Thai Patients with Mild to Moderate Dementia.
Cytochrome P450 (CYP450) Interactions Involving Atypical Antipsychotics are Common in Community-Dwelling Older Adults Treated for Behavioral and Psychological Symptoms of Dementia.
Cytochrome P450 2D6 Phenotyping in an Elderly Population With Dementia and Response to Galantamine in Dementia: A Pilot Study.
Genetic Editing and Pharmacogenetics in Current And Future Therapy Of Neurocognitive Disorders.
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Influence of Pathogenic and Metabolic Genes on the Pharmacogenetics of Mood Disorders in Alzheimer's Disease.
Influence of pharmacogenetic factors on Alzheimer's disease therapeutics.
Molecular pathology and pharmacogenomics in Alzheimer's disease: Polygenic-related effects of multifactorial treatments on cognition, anxiety and depression.
No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population.
No evidence of an association between CYP2D6 polymorphisms among Japanese and dementia with Lewy bodies.
Pharmacogenomics in Alzheimer's disease.
Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia.
Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia.
[Is it personalized treatment of dementia based on the CYP2D6 gene polymorphism possible?]
[Overactive bladder in a complicated patient: which drug to choose?]
Dementia, Vascular
Influence of CYP2D6, CYP3A5, ABCB1, APOE polymorphisms and nongenetic factors on donepezil treatment in patients with Alzheimer's disease and vascular dementia.
Dengue
Insecticide resistance and underlying targets-site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan.
Molecular cloning and xenobiotic induction of seven novel cytochrome P450 monooxygenases in Aedes albopictus.
Pyrethroid Resistance in Malaysian Populations of Dengue Vector Aedes aegypti Is Mediated by CYP9 Family of Cytochrome P450 Genes.
The Cytochrome P450 gene CYP6P12 confers pyrethroid resistance in kdr-free Malaysian populations of the dengue vector Aedes albopictus.
Dent Disease
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
deoxyguanosine kinase deficiency
Targeted Next-Generation Sequencing in Diagnostic Approach to Monogenic Cholestatic Liver Disorders-Single-Center Experience.
Dermatitis
Decreased lymphocyte aryl hydrocarbon hydroxylase and glutathione S-transferase activities in patients with hand dermatitis.
Trichloroethylene-induced hypersensitivity dermatitis was associated with hepatic metabolic enzyme genes and immune-related genes.
[Relationship between gene polymorphism of CYP2E1, CYP1A1, IL-4 and medicamentosa-like der-matitis induced by trichloroethylene.]
Dermatitis, Allergic Contact
Decreased lymphocyte aryl hydrocarbon hydroxylase and glutathione S-transferase activities in patients with hand dermatitis.
Dermatitis, Atopic
A Promoter Polymorphism of the Vitamin D Metabolism Gene Cyp24a1 is Associated with Severe Atopic Dermatitis in Adults.
A rare variant in CYP27A1 and its association with atopic dermatitis with high serum total IgE.
Aryl hydrocarbon receptor expression in serum, peripheral blood mononuclear cells, and skin lesions of patients with atopic dermatitis and its correlation with disease severity.
Evaluation of Potential Disease-Mediated Drug-Drug Interaction in Patients With Moderate-to-Severe Atopic Dermatitis Receiving Dupilumab.
Dermatitis, Contact
17(S),18(R)-epoxyeicosatetraenoic acid generated by cytochrome P450 BM-3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G-protein-coupled receptor 40-mediated neutrophil suppression.
Cytochrome P450 1B1: a major P450 isoenzyme in human blood monocytes and macrophage subsets.
Metabolic requirements for induction of contact hypersensitivity to immunotoxic polyaromatic hydrocarbons.
Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1.
Dermatitis, Phototoxic
Major furocoumarins in grapefruit juice II: Phototoxicity, photogenotoxicity, and inhibitory potency vs. cytochrome P450 3A4 activity.
Profile of a Novel Anionic Fluoroquinolone-Delafloxacin.
Single-step phototoxic selection procedure for isolating cells that possess aryl hydrocarbon hydroxylase.
Dermoid Cyst
Genetics of Congenital Corneal Opacification-Impact on Diagnosis and Treatment.
Diabetes Mellitus
A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese.
Antiplatelet therapy: Controversial aspects.
Association Between the CYP2C9 Genotype and Hypoglycemia Among Patients With Type 2 Diabetes Receiving Sulfonylurea Treatment: A Meta-analysis.
Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus.
Association of CYP19A1 and CYP1A2 genetic polymorphisms with type 2 diabetes mellitus risk in the Chinese Han population.
Association of Cytochrome P450 Genetic Variants with Clopidogrel Resistance and Outcomes in Acute Ischemic Stroke.
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
Clinical Predictors Associated With Warfarin Sensitivity.
Clopidogrel utilization in patients with coronary artery disease and diabetes mellitus: should we determine CYP2C19*2 genotype?
Comparing the protective effects of three sulfur compounds against acrylonitrile-induced acute toxicity in CYP2E1-induced rats.
Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism.
CYP2C19 or CYP3A5 Genotyping Does Not Predict Clinical Response to Clopidogrel.
Cytochrome P450 2C9 *2 and *3 polymorphisms and the dose and effect of sulfonylurea in type II diabetes mellitus.
Derivation, Validation, and Prognostic Utility of a Prediction Rule for Nonresponse to Clopidogrel: The ABCD-GENE Score.
Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans.
Distribution of CYP2C8 and CYP2C9 amino acid substitution alleles in South Indian diabetes patients: A genotypic and computational protein phenotype study.
EETs/sEH in diabetes and obesity-induced cardiovascular diseases.
Effect of CYP2C9 polymorphisms on prescribed dose and time-to-stable dose of sulfonylureas in primary care patients with Type 2 diabetes mellitus.
Effect of type 2 diabetes mellitus on the pharmacokinetics and transplacental transfer of nifedipine in hypertensive pregnant women.
Effects of Diabetes Mellitus on the Disposition of Tofacitinib, a Janus Kinase Inhibitor, in Rats.
Evaluating the impact of type 2 diabetes mellitus on CYP450 metabolic activities: protocol for a case-control pharmacokinetic study.
Evaluation of the Associations of GC and CYP2R1 Genes and Gene-Obesity Interactions with Type 2 Diabetes Risk in a Chinese Rural Population.
Evaluation of the influence of diabetes mellitus on antipyrine metabolism and CYP1A2 and CYP2D6 activity.
Frequency of CYP2C9 (*2, *3 and IVS8-109A>T) allelic variants, and their clinical implications, among Mexican patients with diabetes mellitus type 2 undergoing treatment with glibenclamide and metformin.
Genetic Polymorphisms of Cytochrome p450 (2C9) Enzyme in Patients with Type 2 Diabetes Mellitus in Turkmen and Fars Ethnic Groups.
In Silico Computations Of Selective Phytochemicals As Potential Inhibitors Against Major Biological Targets Of Diabetes Mellitus.
Influence of CYP2C9 gene polymorphisms on response to glibenclamide in type 2 diabetes mellitus patients.
Influence of genetic polymorphisms of CYP3A5 and ABCB1 on sirolimus pharmacokinetics, patient and graft survival and other clinical outcomes in renal transplant.
Lymphocyte cytochrome P450 expression: inducibility studies in male Wistar rats.
Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
Non-alcoholic Steatohepatitis (NASH) Drug Discovery - Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development.
Pharmacokinetic parameters of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, after intravenous and oral administration of chlorzoxazone to liver cirrhotic rats with diabetes mellitus.
Pharmacokinetics of drugs in rats with diabetes mellitus induced by alloxan or streptozocin: comparison with those in patients with type I diabetes mellitus.
Pharmacokinetics of oltipraz in diabetic rats with liver cirrhosis.
Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation.
Risk factors for post-transplant diabetes mellitus in renal transplant: Role of genetic variability in the CYP450-mediated arachidonic acid metabolism.
Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus.
The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects.
The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPAR? on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes.
Transcriptomic profiling as biological markers of depression - A pilot study in unipolar and bipolar women.
Trigonella stellata reduced the deleterious effects of diabetes mellitus through alleviation of oxidative stress, antioxidant- and drug-metabolizing enzymes activities.
[Maximal initial dose of simvastatin causing acute renal failure through rhabdomyolysis: risk factors, pathomechanism and therapy related to a case]
[Perfusion and metabolism of liver and splanchnic nerve area under sevoflurane anesthesia]
Diabetes Mellitus, Experimental
Induction and suppression of renal and hepatic cytochrome P450-dependent monooxygenases by acute and chronic streptozotocin diabetes in hamsters.
[Status of the monooxygenase enzyme system in rat and rabbit organs in sugar diabetes and upon insulin administration]
Diabetes Mellitus, Type 1
Association of increased renal Cyp24a1 gene expression with low plasma 1,25-dihydroxyvitamin D levels in rats with streptozotocin-induced diabetes.
Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes.
Cytochrome P450IIE1 is elevated in lymphocytes from poorly controlled insulin-dependent diabetics.
EETs/sEH in diabetes and obesity-induced cardiovascular diseases.
Evaluation of the influence of diabetes mellitus on antipyrine metabolism and CYP1A2 and CYP2D6 activity.
Extrahepatic expression of P450 proteins in insulin-dependent diabetes mellitus.
Lymphocyte cytochrome P450-CYP2E1 expression in human IDDM subjects.
Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.
Taurine Is More Effective than Melatonin on Cytochrome P450 2E1 and Some Oxidative Stress Markers in Streptozotocin-Induced Diabetic Rats.
Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats.
Viral triggers for autoimmunity: Is the 'glass of molecular mimicry' half full or half empty?
Vitamin D Pathway Genetic Variation and Type 1 Diabetes: A Case-Control Association Study.
[Vitamin D3 availability and functional activity of peripheral blood phagocytes in experimental type 1 diabetes].
Diabetes Mellitus, Type 2
A Pilot Study towards the Impact of Type 2 Diabetes on the Expression and Activities of Drug Metabolizing Enzymes and Transporters in Human Duodenum.
A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese.
Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria.
Analysis of CYP2C9*2, CYP2C19*2, and CYP2D6*4 polymorphisms in patients with type 2 diabetes mellitus.
Androgen receptor overexpression in prostate cancer in type 2 diabetes.
Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study.
Association Between the CYP2C9 Genotype and Hypoglycemia Among Patients With Type 2 Diabetes Receiving Sulfonylurea Treatment: A Meta-analysis.
Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus.
Association of CYP19A1 and CYP1A2 genetic polymorphisms with type 2 diabetes mellitus risk in the Chinese Han population.
Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene.
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Calpain-10 gene polymorphisms and type 2 diabetes in West Africans: the Africa America Diabetes Mellitus (AADM) Study.
Chronic Inflammatory Status Observed in Patients with Type 2 Diabetes Induces Modulation of Cytochrome P450 Expression and Activity.
Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study.
CYP2C19 or CYP3A5 Genotyping Does Not Predict Clinical Response to Clopidogrel.
CYP2C8 and SLCO1B1 Variants and Therapeutic Response to Thiazolidinediones in Patients With Type 2 Diabetes.
CYP2C9*3 gene variant contributes independently to glycaemic control in patients with type 2 diabetes treated with glibenclamide.
CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients.
Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Distribution of CYP2C8 and CYP2C9 amino acid substitution alleles in South Indian diabetes patients: A genotypic and computational protein phenotype study.
EETs/sEH in diabetes and obesity-induced cardiovascular diseases.
Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.
Effect of CYP2C9 genetic polymorphisms on the efficacy and pharmacokinetics of glimepiride in subjects with type 2 diabetes.
Effect of CYP2C9 polymorphisms on prescribed dose and time-to-stable dose of sulfonylureas in primary care patients with Type 2 diabetes mellitus.
Effects of type 1 and type 2 diabetes on the pharmacokinetics of tramadol enantiomers in patients with neuropathic pain phenotyped as cytochrome P450 2D6 extensive metabolizers.
Eicosanoids, ?-cell function, and diabetes.
Evaluating the effect of type 2 diabetes mellitus on CYP450 enzymes and P-gp activities, before and after glycemic control: A protocol for a case-control pharmacokinetic study.
Evaluating the impact of type 2 diabetes mellitus on CYP450 metabolic activities: protocol for a case-control pharmacokinetic study.
Evaluation of the Associations of GC and CYP2R1 Genes and Gene-Obesity Interactions with Type 2 Diabetes Risk in a Chinese Rural Population.
Evaluation of the pharmacokinetic interaction between the dipeptidyl peptidase-4 inhibitor linagliptin and pioglitazone in healthy volunteers.
Genetic analysis of the NAT2 and CYP2D6 polymorphisms in white patients with non-insulin-dependent diabetes mellitus.
Genetic Polymorphisms of Cytochrome p450 (2C9) Enzyme in Patients with Type 2 Diabetes Mellitus in Turkmen and Fars Ethnic Groups.
Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History.
Half-Life of Sulfonylureas in HNF1A and HNF4A Human MODY Patients is not Prolonged as Suggested by the Mouse Hnf1a(-/-) Model.
Identification of genes and pathways in esophageal adenocarcinoma using bioinformatics analysis.
Identification of key genes involved in type 2 diabetic islet dysfunction: a bioinformatics study.
Influence of CYP2C9 gene polymorphisms on response to glibenclamide in type 2 diabetes mellitus patients.
Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers.
Inhibitory effects of type 2 diabetes serum components in P450 inhibition assays can potential diagnose asymptomatic diabetic mice.
Interaction between heavy smoking and CYP2A6 genotypes on type 2 diabetes and its possible pathways.
Loss-of-Function CYP2C9 Variants Improve Therapeutic Response to Sulfonylureas in Type 2 Diabetes: A Go-DARTS Study.
Loss-of-function CYP2C9 variants: finding the correct clinical role for Type 2 diabetes pharmacogenetic testing.
Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium.
Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity.
Modulation of CYP450 Activities in Patients With Type 2 Diabetes.
NAT2 polymorphism associated with plasma glucose concentration in Canadian Oji-Cree.
Non-alcoholic Steatohepatitis (NASH) Drug Discovery - Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development.
Ovarian function in women with non-insulin dependent diabetes mellitus.
Personalized medicine in diabetes: the role of 'omics' and biomarkers.
Pharmacodynamic Effect of Cilostazol Plus Standard Clopidogrel Versus Double-Dose Clopidogrel in Patients With Type 2 Diabetes Undergoing Percutaneous Coronary Intervention.
Pharmacogenetics of Oral Antidiabetic Drugs.
Sex differences in the effect of cytochrome P450 2C19 polymorphisms on the risk of diabetic retinopathy: a retrospective longitudinal study in Japanese patients with type 2 diabetes.
The CYP19 gene and associations with androgens and abdominal obesity in premenopausal women.
The Effect of CYP2C9 Genotype Variants in Type 2 Diabetes on the Pharmacological Effectiveness of Sulfonylureas, Diabetic Retinopathy, and Nephropathy.
The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects.
The pharmacokinetics of pioglitazone in Thai healthy subjects.
The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPAR? on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes.
Thiazolidinediones for type 2 diabetes. No evidence exists that pioglitazone induces hepatic cytochrome P450 isoform CYP3A4.
Use of 4?-Hydroxycholesterol Plasma Concentrations as an Endogenous Biomarker of CYP3A Activity: Clinical Validation in Individuals With Type 2 Diabetes.
Vitamin D in Type 2 Diabetes: Genetic Susceptibility and the Response to Supplementation.
Diabetes, Gestational
Hypoglycemia and Glycemic Control With Glyburide in Women With Gestational Diabetes and Genetic Variants of Cytochrome P450 2C9 and/or OATP1B3.
Knockdown of CYP1B1 suppresses the behavior of the extravillous trophoblast cell line HTR-8/SVneo under hyperglycemic condition.
Placenta expression of vitamin D and related genes in pregnant women with gestational diabetes mellitus.
The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process.
Diabetic Cardiomyopathies
Role of Cytochrome p450 and Soluble Epoxide Hydrolase Enzymes and Their Associated Metabolites in the Pathogenesis of Diabetic Cardiomyopathy.
Diabetic Nephropathies
CYP24A1 exacerbated activity during diabetes contributes to kidney tubular apoptosis via caspase-3 increased expression and activation.
Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone.
Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy.
Targeted CYP2E1 quantification and its correlation to currently acceptable clinical biochemical indices.
Targeting oxidative stress and anti-oxidant defence in diabetic kidney disease.
Diabetic Neuropathies
Duloxetine: new indication. Depression and diabetic neuropathy: too many adverse effects.
Diabetic Retinopathy
Sex differences in the effect of cytochrome P450 2C19 polymorphisms on the risk of diabetic retinopathy: a retrospective longitudinal study in Japanese patients with type 2 diabetes.
The Effect of CYP2C9 Genotype Variants in Type 2 Diabetes on the Pharmacological Effectiveness of Sulfonylureas, Diabetic Retinopathy, and Nephropathy.
[Behavior of the olfactive function in patients affected by diabetic retinopathies]
DiGeorge Syndrome
A Case of 22q11.2 Deletion Syndrome with Peters Anomaly, Congenital Glaucoma, and Heterozygous Mutation in CYP1B1.
Digestive System Neoplasms
Characteristic CYP2A6 genetic polymorphisms detected by TA cloning-based sequencing in Chinese digestive system cancer patients with S-1 based chemotherapy.
Functional polymorphisms in the CYP2C19 gene contribute to digestive system cancer risk: evidence from 11,042 subjects.
Diplopia
Possible Genetic Determinants of Response to Phenytoin in a Group of Colombian Patients With Epilepsy.
Disorders of Excessive Somnolence
Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia.
Disorders of Sex Development
Evidence of endocrine alteration in the red mullet, Mullus barbatus from the NW Mediterranean.
Hypothalamic-pituitary-ovarian axis during infancy, early and late prepuberty in an aromatase-deficient girl who is a compound heterocygote for two new point mutations of the CYP19 gene.
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
P450 Oxidoreductase deficiency: Analysis of mutations and polymorphisms.
Sex differences in autophagy-mediated diseases: toward precision medicine.
Down Syndrome
Variants in CYP17 and CYP19 cytochrome P450 genes are associated with onset of Alzheimer's disease in women with down syndrome.
Drug Eruptions
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Drug Hypersensitivity
The metabolic rationale for a lack of cross-reactivity between sulfonamide antimicrobials and other sulfonamide-containing drugs.
Drug Hypersensitivity Syndrome
Presence of a single nucleotide polymorphism (RS3758581) in a boy with DRESS syndrome.
Drug Resistant Epilepsy
Influence of genetic variants of CYP2D6, CYP2C9, CYP2C19 and CYP3A4 on antiepileptic drug metabolism in pediatric patients with refractory epilepsy.
Possible role of CYP2C9 & CYP2C19 single nucleotide polymorphisms in drug refractory epilepsy.
Drug-Related Side Effects and Adverse Reactions
A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity.
A history of the roles of cytochrome P450 enzymes in the toxicity of drugs.
A new simple diagnostic assay for the identification of the major CYP2D6 genotypes by DNA sequencing analysis.
A Review of the Important Role of CYP2D6 in Pharmacogenomics.
A service improvement project to review prescribing information provided by general practitioners for new referrals to a UK National Health Service hospital pain clinic: potential implications of CYP2D6 enzyme inhibition.
A Single Site Population Study to Investigate CYP2D6 Phenotype of Patients with Persistent Non-Malignant Pain.
Adverse drug reactions following nonresponse in a depressed patient with CYP2D6 deficiency and low CYP 3A4/5 activity.
Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers.
Allele and genotype frequencies of CYP2B6 in a Turkish population.
Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages.
An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics.
An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.
Analysis of Elevated Levels of Nandrolone Decanoate Induced Cytochrome- P450 Alterations in Mice.
Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine.
Application of support vector machines to in silico prediction of cytochrome p450 enzyme substrates and inhibitors.
Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia.
Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy.
Associations of CYP2C9 and CYP2C19 Pharmacogenetic Variation with Phenytoin-Induced Cutaneous Adverse Drug Reactions.
Autoantibodies against cytochrome P450s in sera of children treated with immunosuppressive drugs.
Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins.
Chimeric cytochrome P450 3A4 used for in vitro prediction of food-drug interactions.
Clinical and toxicological relevance of CYP2C9: drug-drug interactions and pharmacogenetics.
Clinical application of pharmacogenomics.
Clinical consequences of cytochrome P450 2C9 polymorphisms.
Clinical evidence of pharmacokinetic changes in thalidomide therapy.
Clinical Utility and Economic Impact of CYP2D6 Genotyping.
Co-administration of statins with cytochrome P450 3A4 inhibitors in a UK primary care population.
Compound I reactivity defines alkene oxidation selectivity in cytochrome P450cam.
Correlation of CYP2B6, CYP2C19, ABCC4 and SOD2 genotype with outcomes in allogeneic blood and marrow transplant patients.
CYP1B1 expression is induced by docetaxel: effect on cell viability and drug resistance.
CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations-Implication for Drug Safety, Dosing, and Individualized Therapy.
CYP2C9 and ABCG2 polymorphisms as risk factors for developing adverse drug reactions in renal transplant patients taking fluvastatin: a case-control study.
CYP2C9 and CYP2C19 Allele and Haplotype Distributions in Four Mestizo Populations from Western Mexico: An Interethnic Comparative Study.
CYP2C9 Genetic Polymorphism is a Potential Predictive Marker for the Efficacy of Rosuvastatin Therapy.
CYP2D6 *6/*6 genotype and drug interactions as cause of haloperidol-induced extrapyramidal symptoms.
CYP2D6 and Antipsychotic Treatment Outcomes in Children and Youth: A Systematic Review.
CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies.
CYP2D6 genotypes in Puerto Rican psychiatry patients with intolerance of antidepressants and antipsychotics.
CYP2D6 genotypes in revolving door patients with bipolar disorders: A case series.
CYP2D6 genotyping for psychiatric patients treated with risperidone: considerations for cost-effectiveness studies.
CYP2D6 genotyping in paediatric patients with autism treated with risperidone: a preliminary cohort study.
CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System-Results From the ADRED Study.
CYP2D6 Metabolism in Frail Elderly Compared to Non-Frail Elderly: A Pilot Feasibility Study.
CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload.
Cytochrome P450 enzyme polymorphisms and adverse drug reactions.
Cytochromes P450 and drug toxicity. Immunological consequences.
Decreases in phenytoin hydroxylation activities catalyzed by liver microsomal cytochrome P450 enzymes in phenytoin-treated rats.
Determination of CYP2D6, CYP2C9 and CYP2C19 genotypes with Tag-It mutation detection assays.
Development and validation of a rapid and reliable real-time PCR method for CYP3A5 genotyping.
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Development of NanoART for HIV Treatment: Minding the Cytochrome P450 (CYP) Enzymes.
Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes.
Differential time-dependent inactivation of P450 3A4 and P450 3A5 by raloxifene: a key role for C239 in quenching reactive intermediates.
Distribution of CYP2D6 and CYP2C19 Polymorphisms Associated with Poor Metabolizer Phenotype in Five Amerindian Groups and Western Mestizos from Mexico.
Distribution of CYP2D6 polymorphism in the Middle Eastern region.
Does obtaining CYP2D6 and CYP2C19 pharmacogenetic testing predict antidepressant response or adverse drug reactions?
Drug extrapyramidal side effects. CYP2D6 genotypes and phenotypes.
Drug extrapyramidal side-effects or not: is there a dextromethorphan phenotype difference?
Drug interactions due to cytochrome P450.
Drug metabolism genotypes and their association with adverse drug reactions in selected populations: a pilot study of methodology.
Drug-drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4.
Drug-induced liver graft toxicity caused by cytochrome P450 poor metabolism.
Drugs impact on CYP-450 enzyme family: A pharmacogenetical study of response variation.
Dynamics and persistence of CYP2D6 inhibition by paroxetine.
Efavirenz and CYP2B6 Polymorphism: Implications for Drug Toxicity and Resistance.
Effect of sodium alterations on hepatic cytochrome P450 3A2 and 2C11 and renal function in rats.
Effects of 24 CYP2D6 variants found in Chinese population on the metabolism of clonidine in vitro.
Evaluation of 24 CYP2D6 Variants on the Metabolism of Nebivolol in vitro.
Evaluation of Phenotypic and Genotypic Variations of Drug Metabolising Enzymes and Transporters in Chronic Pain Patients Facing Adverse Drug Reactions or Non-Response to Analgesics: A Retrospective Study.
Evaluation of the Effects of Cytochrome P450 Non-synonymous Single-nucleotide Polymorphisms on DBZ Metabolism and Inhibition Potential.
Evolution of pharmacogenomics.
Expression of autoantibodies to specific cytochromes P450 in a case of disulfiram hepatitis.
Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness.
Factors affecting the development of adverse drug reactions to ?-blockers in hospitalized cardiac patient population.
Fast Screening Technology for Drug Emergency Management: Predicting Suspicious SNPs for ADR with Information Theory-based Models.
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9.
Frequency of mutated allele CYP2D6*4 in the Turkish population.
From Genotype to Phenotype: Cytochrome P450 2D6-Mediated Drug Clearance in Humans.
Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities.
Functional Characterization of Wild-type and 49 CYP2D6 Allelic Variants for N-desmethyltamoxifen 4-hydroxylation Activity.
Functional role of Ile264 in CYP2C8: mutations affect haem incorporation and catalytic activity.
Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia.
Genetic polymorphism and toxicology--with emphasis on cytochrome p450.
Genetic polymorphism of cytochrome P450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactions.
Genetic polymorphisms of drug metabolism. Possible implications during development.
Genetic predisposition to acute gastrointestinal bleeding after NSAIDs use.
Genetic Variants of Cytochrome CYP2D6 in Two Mixed Chilean Populations.
Genetics and variability in opioid response.
Genome-based biomarkers for adverse drug effects, patient enrichment and prediction of drug response, and their incorporation into clinical trial design.
Hepatic cytochrome P450 regulation in disease states.
HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles.
Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms.
Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)-Mediated Inactivation of Reactive Quinoneimine Metabolites of Diclofenac and Mefenamic Acid.
Identification of CYP2D6 null variants among long-stay, chronic psychiatric inpatients: is it strictly necessary?
Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance.
Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia.
Impact of Efavirenz Metabolism on Loss to Care in Older HIV+ Africans.
Importance of cytochrome P450 (CYP450) in adverse drug reactions due to drug-drug interactions: a PharmacoVigilance study in France.
In human therapy, is the drug-drug interaction or the adverse drug reaction the issue?
In Silico Prediction of CYP2C8 Inhibition with Machine-Learning Methods.
Inactivation of CYP3A4 by Benzbromarone in Human Liver Microsomes.
Individualized drug therapy.
Influence of short-term use of dexamethasone on the pharmacokinetics of ifosfamide in patients.
Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals.
Intravenous carbamazepine: a new formulation of a familiar drug.
Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis.
Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group.
Long-term administration of escitalopram in patients with social anxiety disorder in Japan.
Maternal-fetal and neonatal pharmacogenomics: a review of current literature.
Measurement of voriconazole in serum and plasma.
Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure-Activity Relationships and Discovery Strategies to Mitigate Drug-Drug Interaction Risks.
Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions.
Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19.
Multiple adverse drug reactions and genetic polymorphism testing: A case report with negative result.
Multiplex genotyping of cytochrome p450 single-nucleotide polymorphisms by use of MALDI-TOF mass spectrometry.
Neuroleptic malignant syndrome in an adolescent with CYP2D6 deficiency.
New cytochrome P450 mechanisms: implications for understanding molecular basis for drug toxicity at the level of the cytochrome.
No evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline.
Optimising Seniors' Metabolism of Medications and Avoiding Adverse Drug Events Using Data on How Metabolism by Their P450 Enzymes Varies with Ancestry and Drug-Drug and Drug-Drug-Gene Interactions.
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin.
Pharmacogenetic Prediction of Individual Variability in Drug Response Based on CYP2D6, CYP2C9 and CYP2C19 Genetic Polymorphisms.
Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin.
Pharmacogenetic testing of CYP2D6 in patients with aripiprazole-related extrapyramidal symptoms: a case-control study.
Pharmacogenetics of Anticoagulation and Clinical Events in Warfarin-Treated Patients: A Register-Based Cohort Study with Biobank Data and National Health Registries in Finland.
Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future.
Pharmacogenetics: implementing personalized medicine.
Physical Performance and Quality of Life in Older Adults: Is There Any Association between Them and Potential Drug Interactions in Polymedicated Octogenarians.
Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism.
Physiologically Based Pharmacokinetic Modelling to Describe the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone According to Cytochrome P450 2D6 Phenotypes.
Pitavastatin therapy in polymedicated patients is associated with a low risk of drug-drug interactions: analysis of real-world and phase 3 clinical trial data.
Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance.
Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.
Polymorphisms and phenotypic analysis of cytochrome P450 2D6 in the Tibetan population.
Polymorphisms of CYP2C19 and CYP2D6 in Israeli ethnic groups.
Prediction By Pharmacogenetics Of Safety And Efficacy Of Non-Steroidal Anti-Inflammatory Drugs: A Review.
Prediction of human cytochrome P450 2B6-substrate interactions using hierarchical support vector regression approach.
Prevalence of CYP2C9 polymorphisms in the south of Europe.
Psychotropic medications and cytochrome P450 2D6: pharmacokinetic considerations in the elderly.
Quantum mechanics/molecular mechanics modeling of regioselectivity of drug metabolism in cytochrome P450 2C9.
Re: no evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline.
Risperidone-associated adverse drug reactions and CYP2D6 polymorphisms in a South African cohort.
Role of cytochrome P450 polymorphisms in the development of pulmonary drug toxicity: a case-control study in the Netherlands.
Screening for genotypic and phenotypic variations in CYP450 activity in patients with therapeutic problems in a psychiatric setting, a retrospective study.
Serotonin syndrome induced by low-dose venlafaxine.
Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice.
Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity.
Significant inhibitory impact of dibenzyl trisulfide and extracts of Petiveria alliacea on the activities of major drug-metabolizing enzymes in vitro: An assessment of the potential for medicinal plant-drug interactions.
Simultaneous measurement of 23 isoforms from the human cytochrome P450 families 1 to 3 by quantitative reverse transcriptase-polymerase chain reaction.
Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9.
The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation.
The development of drug metabolising enzymes and their influence on the susceptibility to adverse drug reactions in children.
The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects.
The enhancement of cardiotoxicity that results from inhibiton of CYP 3A4 activity and hERG channel by berberine in combination with statins.
The Human Cytochrome P450 Allele Nomenclature Committee Web Site : Submission Criteria, Procedures, and Objectives.
The human cytochrome P450 Allele Nomenclature Committee Web site: submission criteria, procedures, and objectives.
The impact of drug interactions on adverse effects of oral oxycodone in male geriatric patients.
The Importance of CYP2E1 in the Pathogenesis of Alcoholic Liver Disease and Drug Toxicity and the Role of the Proteasome.
The influence of CYP3A5 polymorphisms on haloperidol treatment in patients with alcohol addiction.
The predictive value of ABCB1, ABCG2, CYP3A4/5 and CYP2D6 polymorphisms for risperidone and aripiprazole plasma concentrations and the occurrence of adverse drug reactions.
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.
The role of genetic polymorphisms in cytochrome P450 and effects of tuberculosis co-treatment on the predictive value of CYP2B6 SNPs and on efavirenz plasma levels in adult HIV patients.
The role of sex, age and genetic polymorphisms of CYP enzymes on the pharmacokinetics of anticholinergic drugs.
The Roles of Long Noncoding RNAs HNF1?-AS1 and HNF4?-AS1 in Drug Metabolism and Human Diseases.
Transfer learning enables prediction of CYP2D6 haplotype function.
Trimipramine pharmacokinetics after intravenous and oral administration in carriers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity.
Update on Allele Nomenclature for Human Cytochromes P450 and the Human Cytochrome P450 Allele (CYP-Allele) Nomenclature Database.
Utilization of pharmacogenomics and therapeutic drug monitoring for opioid pain management.
Variation in the CYP2D6 genotype is not associated with carvedilol dose changes in patients with heart failure.
Warfarin Dosing in a Patient with CYP2C9(?)3(?)3 and VKORC1-1639 AA Genotypes.
Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7.
[Effects of Reduning injection on activity of hepatic microsomal CYP450 isozymes in rats].
[Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese]
[Genetic polymorphisms in drug-metabolizing enzymes]
[Genotrping of CYP2D6 and CYP2C19]
Ductus Arteriosus, Patent
Cimetidine-associated patent ductus arteriosus is mediated via a cytochrome P450 mechanism independent of H2 receptor antagonism.
Polymorphisms in CYP2C9 are associated with response to indomethacin among neonates with patent ductus arteriosus.
Duodenal Ulcer
Polymorphisms and the pocketbook: the cost-effectiveness of cytochrome P450 2C19 genotyping in the eradication of Helicobacter pylori infection associated with duodenal ulcer.
Duodenogastric Reflux
Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux.
Dwarfism
Arabidopsis thaliana RALF1 opposes brassinosteroid effects on root cell elongation and lateral root formation.
The DWF4 gene of Arabidopsis encodes a cytochrome P450 that mediates multiple 22alpha-hydroxylation steps in brassinosteroid biosynthesis.
Dyskinesias
A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia.
Abnormal movements and tardive dyskinesia in smokers and nonsmokers with schizophrenia genotyped for cytochrome P450 2D6.
Association between cytochrome P4502D6 (CYP2D6) genotype, antipsychotic exposure, and abnormal involuntary movement scale (AIMS) score.
Long-term safety and efficacy of deutetrabenazine for the treatment of tardive dyskinesia.
Methylphenidate-Induced Chorea Due to Possible Cytochrome P450 Metabolism Heterogeneity - A Rare Case.
The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation.
Dyslipidemias
Cyclocarya paliurus Leaves Tea Improves Dyslipidemia in Diabetic Mice: A Lipidomics-Based Network Pharmacology Study.
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.
Effect of pigeon pea (Cajanus cajan L.) on high-fat diet-induced hypercholesterolemia in hamsters.
Low myopathy rates associated with statins as monotherapy or combination therapy with interacting drugs in a group model health maintenance organization.
Non-alcoholic Steatohepatitis (NASH) Drug Discovery - Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development.
Ovariectomy-Induced Hepatic Lipid and Cytochrome P450 Dysmetabolism Precedes Serum Dyslipidemia.
Pharmacokinetic study of rosuvastatin in males and females.
Rhabdomyolysis in an HIV-Infected Patient on Anti-Retroviral Therapy Precipitated by High-Dose Pravastatin.
Dystonia
Acute pharmacogenetic dystonic reactions in a family with the CYP2D6 *41 allele: a case report.
Metoclopramide-Induced Acute Dystonic Reactions May Be Associated With the CYP2D6 Poor Metabolizer Status and Pregnancy-Related Hormonal Changes.
[Acute dyskinetic syndrome during chloropromazine treatment of a female patient with CYP2D6 poor metabolism phenotype]
Echinococcosis
[Associations of the genotypes of the CYP1A1 gene with predisposition to hydatid disease caused by Echinococcus granulosus strain G1]
Ectropion
Molecular Characterization Of Newborn Glaucoma Including A Distinct Aniridic Phenotype.
Embolic Stroke
Effect of race/ethnicity on the efficacy of warfarin : potential implications for prevention of stroke in patients with atrial fibrillation.
Warfarin loading dose guided by pharmacogenetics is effective and safe in cardioembolic stroke patients - a randomized, prospective study.
Embolism
Adverse Interaction between Capecitabine and Warfarin Resulting in Altered Coagulation Parameters: A Review of the Literature Starting from a Case Report.
Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation.
Warfarin pharmacogenetics: development of a dosing algorithm for Omani patients.
Embolism and Thrombosis
Adverse Interaction between Capecitabine and Warfarin Resulting in Altered Coagulation Parameters: A Review of the Literature Starting from a Case Report.
Empyema
CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications.
Encephalitis
Identification of cytochrome P450 isoforms involved in the metabolism of Syl930, a selective S1PR1 agonist acting as a potential therapeutic agent for autoimmune encephalitis.
End Stage Liver Disease
Effects of plasma from patients with acute on chronic liver failure on function of cytochrome P450 in immortalized human hepatocytes.
Endocrine System Diseases
The single-nucleotide polymorphism rs743572 of CYP17A1 shows significant association with polycystic ovary syndrome: a meta-analysis.
Endometrial Hyperplasia
Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies.
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
CYP1A1 gene polymorphism and risk of endometrial hyperplasia and endometrial carcinoma.
Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.
Functional investigation on aromatase in endometrial hyperplasia in polycystic ovary syndrome cases.
In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia.
[Aromatase (P450AROM) mRNA expression in normal, hyperplastic and malignant endometrium and aromatase activity in endometrial cancer tissue culture]
Endometrial Neoplasms
7,12-Dimethylbenzanthracene induces apoptosis in RL95-2 human endometrial cancer cells: ligand-selective activation of cytochrome P450 1B1.
A remark about CYP1A1 Thr461Asn genotype frequencies in a recent endometrial cancer case-control study.
Altered expression of lysophosphatidic acid receptors, in association with the synthesis of estrogens and androgens in type 1 endometrial cancer biology.
Aromatase cytochrome P450 gene expression in endometrial carcinoma.
Aromatase expression in endometriosis.
Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies.
Aromatase in the context of breast and endometrial cancer. A review.
Association between cytochrome P450 1A1 MspI polymorphism and endometrial cancer risk: a meta-analysis.
Association of CYP1B1 gene polymorphisms and the positive expression of estrogen alpha and estrogen beta with endometrial cancer risk.
Association of CYP1B1 gene polymorphisms with susceptibility to endometrial cancer: a meta-analysis.
Benzo[a]pyrene induces apoptosis in RL95-2 human endometrial cancer cells by cytochrome P450 1A1 activation.
Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes.
CYP17 and CYP19 genetic polymorphisms in endometrial cancer: association with intratumoral aromatase activity.
CYP19 (aromatase) haplotypes and endometrial cancer risk.
CYP19 gene expression and aromatase activity in endometrial cancer tissue: importance of the type of the disease.
CYP19 gene polymorphism in endometrial cancer patients.
CYP1A1 gene polymorphism and risk of endometrial hyperplasia and endometrial carcinoma.
CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility.
CYP1B1 gene in endometrial cancer.
CYP1B1 gene polymorphisms have higher risk for endometrial cancer, and positive correlations with estrogen receptor alpha and estrogen receptor beta expressions.
Cytochrome P450 1A1 gene polymorphisms and endometrial cancer risk: a meta-analysis.
Cytochrome P450 1A1, cigarette smoking, and risk of endometrial cancer (United States).
Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and endometrial cancer risk in Chinese women.
Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility.
Cytochrome P450 1B1 gene polymorphisms and postmenopausal endometrial cancer risk.
Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity.
Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: Lower levels of CYP1B1 and increased expression of S-COMT.
Expression of enzyme associated with steroid hormone synthesis and local production of steroid hormone in endometrial carcinoma cells.
Expression profile of CYP1A1 and CYP1B1 enzymes in endometrial tumors.
Functional significance of cytochrome P450 1B1 in endometrial carcinogenesis.
Genetic factors in catechol estrogen metabolism in relation to the risk of endometrial cancer.
Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility.
Hormonal imbalance in two types of endometrial cancer and genetic polymorphism of steroidogenic enzymes.
Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer.
Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk: a meta-analysis.
Letter regarding Li et al. entitled "Quantitative assessment of the association between CYP1A1 A4889G polymorphism and endometrial cancer risk"
No Association Between the CYP1B1 C4326G Polymorphism and Endometrial Cancer Risk: a Meta-analysis.
Polymorphism of the ERalpha and CYP1B1 genes in endometrial cancer in a Polish subpopulation.
Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk.
Preventive Efficacy of Vanillic Acid on Regulation of Redox Homeostasis, Matrix Metalloproteinases and Cyclin D1 in Rats Bearing Endometrial Carcinoma.
Progesterone potentiates the growth inhibitory effects of calcitriol in endometrial cancer via suppression of CYP24A1.
Prostaglandin E2 triggers cytochrome P450 17? hydroxylase overexpression via signal transducer and activator of transcription 3 phosphorylation and promotes invasion in endometrial cancer.
Quantitative assessment of the association between CYP1A1 A4889G polymorphism and endometrial cancer risk.
Retraction: CYP1B1 Gene Polymorphisms Have Higher Risk for Endometrial Cancer, and Positive Correlations with Estrogen Receptor ? and Estrogen Receptor ? Expressions.
Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma.
Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer.
Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT).
Susceptibility to endometrial cancer: influence of allelism at p53, glutathione S-transferase (GSTM1 and GSTT1) and cytochrome P-450 (CYP1A1) loci.
The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements.
The influence of single nucleotide polymorphisms on the association between dietary acrylamide intake and endometrial cancer risk.
The polymorphisms of the CYP17 and CYP19 genes in endometrial cancer patients.
The postmenopausal ovary as an androgen-producing gland; hypothesis on the etiology of endometrial cancer.
The T/C polymorphism of the CYP17 gene and G/A polymorphism of the CYP19 gene in endometrial cancer.
[A polymorphism study of the CYP19 gene in endometrial cancer patients]
[Aromatase (P450AROM) mRNA expression in normal, hyperplastic and malignant endometrium and aromatase activity in endometrial cancer tissue culture]
[Genetic polymorphism of steroidogenic enzymes and steroid receptor level in tumors of the reproductive system]
[Polymorphisms of CYP1B1 and COMT in breast and endometrial cancer]
[Preliminary study of gene expression profiling in human type I and II endometrial carcinoma]
[The risk of endometrial cancer appearance and CYP19 and COMT gene polymorphism]
Endometriosis
Activin A Stimulates Aromatase via the ALK4-Smad Pathway in Endometriosis.
An Analysis of ESR2 and CYP19A1 Gene Expression Levels in Women With Endometriosis.
Aromatase and endometriosis.
Aromatase and endometriosis: estrogens play a role.
Aromatase expression in endometriosis.
Aromatase Inhibitors for Endometriosis-Associated Infertility; Do We Have Sufficient Evidence?
Aromatase P450 messenger RNA expression in eutopic endometrium is not a specific marker for pelvic endometriosis.
Association between endometriosis and genetic polymorphisms of the estradiol-synthesizing enzyme genes HSD17B1 and CYP19.
Association between single nucleotide polymorphism of the CYP19A1 and ESR2 genes and endometriosis.
Association of CYP1A1 (cytochrome P450) MspI polymorphism in women with endometriosis.
Association of endometriosis risk and genetic polymorphisms involving biosynthesis of sex steroids and their receptors: an updating meta-analysis.
Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women.
Association study between CYP17 gene polymorphism and endometriosis risk: A meta-analysis.
Common variants in the CYP2C19 gene are associated with susceptibility to endometriosis.
COMT 158G/A and CYP1B1 432C/G polymorphisms increase the risk of endometriosis and adenomyosis: a meta-analysis.
CYP17 and CYP19 gene polymorphisms in women affected with endometriosis.
CYP17, CYP1A1 and COMT polymorphisms and the risk of adenomyosis and endometriosis in Taiwanese women.
CYP17A1 rs743572 polymorphism might contribute to endometriosis susceptibility: evidences from a case-control study.
CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women.
CYP1A1, CYP19, and GSTM1 polymorphisms increase the risk of endometriosis.
Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity.
Detection of endometriosis using immunocytochemistry of P450 Aromatase expressions in eutopic endometrial cells obtained from menstrual sloughing: a diagnostic study.
Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: estradiol regulation.
Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: A source of excessive hydroxy-estrogens and ROS?
Effect of letrozole on estradiol production and P450 aromatase messenger RNA expression of cultured luteinized granulosa cells from women with and without endometriosis.
Effect of Yikun Neiyi Wan on the expression of aromatase P450, COX-2, and ER related receptor in endometrial cells in vitro from patients with endometriosis.
Elevated expression of CYP1A1 and gamma-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium.
Endometrial aromatase mRNA as a possible screening tool for advanced endometriosis and adenomyosis.
Endometriosis as a detrimental condition for granulosa cell steroidogenesis and development: From molecular alterations to clinical impact.
Endometriosis: the pathophysiology as an estrogen-dependent disease.
Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis.
Expression of Ah receptor and dioxin-related genes in human uterine endometrium in women with or without endometriosis.
Expression of AhR and ARNT mRNA in cultured human endometrial explants exposed to TCDD.
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium.
Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues.
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis.
Functional analyses of endometriosis-related polymorphisms in the estrogen synthesis and metabolism-related genes.
Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue.
Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas.
Gonadotropin-Releasing Hormone Agonist Reduces Aromatase Cytochrome P450 and Cyclooxygenase-2 in Ovarian Endometrioma and Eutopic Endometrium of Patients with Endometriosis.
GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and their relationship with advanced stages of endometriosis in South Indian women.
High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome.
Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis.
IGF-I stimulates ER? and aromatase expression via IGF1R/PI3K/AKT-mediated transcriptional activation in endometriosis.
Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis.
Increased expression of IgE-dependent histamine-releasing factor in endometriotic implants.
Interaction between cytochrome P450 gene polymorphisms and serum organochlorine TEQ levels in the risk of endometriosis.
Is cytochrome P450 3A4 regulated by menstrual cycle hormones in control endometrium and endometriosis?
Linkage and association studies of the relationship between endometriosis and genes encoding the detoxification enzymes GSTM1, GSTT1 and CYP1A1.
Liver receptor homologue-1 and steroidogenic factor-1 expression in cultured granulosa cells from patients with endometriosis: A preliminary study.
Low-penetrance genes are associated with increased susceptibility to endometriosis.
Metformin Suppresses Prostaglandin E2-Induced Cytochrome P450 Aromatase Gene Expression and Activity via Stimulation of AMP-Activated Protein Kinase in Human Endometriotic Stromal Cells.
Pharmacological treatment of endometriosis: experience with aromatase inhibitors.
Polymorphic variants of CYP17 and CYP19A and risk of infertility in endometriosis.
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Polymorphisms and endometriosis: a systematic review and meta-analyses.
Polymorphisms and haplotypes of the gene encoding the estrogen-metabolizing CYP19 gene in Korean women: no association with advanced-stage endometriosis.
Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium.
Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells.
Regulation of aromatase P450 expression in endometriotic and endometrial stromal cells by CCAAT/enhancer binding proteins (C/EBPs): decreased C/EBPbeta in endometriosis is associated with overexpression of aromatase.
Relationship between MspI polymorphism of CYP1A1 gene and the risk of endometriosis in an Iranian population: A case-control study.
Role of cytochrome P450 2C19 polymorphisms and body mass index in endometriosis: A case-control study.
Serum dioxin-like compounds and aromatase (CYP19) expression in endometriotic tissues.
Single nucleotide polymorphisms and haplotypes of the genes encoding the CYP1B1 in Korean women: no association with advanced endometriosis.
Smad3/4 Binding to Promoter II of P450arom So As to Regulate Aromatase Expression in Endometriosis.
Spatially heterogeneous expression of aromatase P450 through promoter II is closely correlated with the level of steroidogenic factor-1 transcript in endometrioma tissues.
Stimulation of aromatase P450 promoter (II) activity in endometriosis and its inhibition in endometrium are regulated by competitive binding of steroidogenic factor-1 and chicken ovalbumin upstream promoter transcription factor to the same cis-acting element.
Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions.
The association between CYP19 polymorphism and endometriosis risk: a system review and meta-analysis.
The association of endometriosis risk and genetic polymorphisms involving dioxin detoxification enzymes: A systematic review.
The cytochrome P4501A1 gene polymorphisms and endometriosis: a meta-analysis.
Valproic acid-induced histone acetylation suppresses CYP19 gene expression and inhibits the growth and survival of endometrial stromal cells.
[Association between gene mutation of cytochrome P450 1A1 in exon 7 A4889G locus and susceptibility to endometriosis]
[Association of the CYP19 gene polymorphism with genetic susceptibility to endometriosis].
[Association of the CYP1B1 gene polymorphism with susceptibility to endometriosis]
[Comparison of steroid metabolism markers in endometrium of women with endometriosis, endometrial hyperplasia and without pathological changes of endometrium]
[Diagnostic value of the detection of aromatase cytochrome P450 and CA125 for endometriosis]
[Expressions of aromatase P450 and estrogen receptor in eutopic and ectopic endometrium in endometriosis and their correlation with endometriosis]
[Molecular biological features of ectopic and eutopic endometrium in genital endometriosis].
[P450Arom and estrogenic microenvironment of eutopic endometria in endometriosis]
[Susceptibility to endometriosis in women of Han Nationality in Guangdong Province associated with Msp I polymorphisms of cytochrome P450 1A1 gene]
Endotoxemia
Alcoholic liver disease.
Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury.
Changes of midazolam pharmacokinetics in Wistar rats treated with lipopolysaccharide: relationship between total CYP and CYP3A2.
CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis.
Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis.
Down-regulation of cytochrome P450 mRNAs and proteins in mice lacking a functional NOS2 gene.
Down-regulation of the expression of three major rat liver cytochrome P450S by endotoxin in vivo occurs independently of nitric oxide production.
Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450.
Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia.
Microsomal Ethanol-Oxidizing System: Success Over 50 Years and an Encouraging Future.
Obesity and Inflammation and Altered Clopidogrel Pharmacokinetics and Pharmacodynamics.
[Inhibition of cytochrome P450 by nitric oxide]
Enterocolitis
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Enuresis
[A case of olfactory hallucination with adult enuresis]
Eosinophilia
Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes.
The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal): evaluation of impacts on fish liver, by histopathology, stereology, vitellogenin and CYP1A immunohistochemistry, after sub-acute exposures of the zebrafish model.
Eosinophilic Esophagitis
Active Eosinophilic Esophagitis Is Associated with Impaired Elimination of Budesonide by Cytochrome P450 3A Enzymes.
Epilepsies, Myoclonic
In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism.
Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group.
Stiripentol: new preparation. Severe myoclonic epilepsy of infancy: promising.
Epilepsies, Partial
Predictors of ovulatory failure in women with epilepsy.
Pregabalin: new drug. Very similar to gabapentin.
Epilepsy
A case of cerebrotendinous xanthomatosis presenting with epilepsy as an initial symptom with a novel V413D mutation in the CYP27A1 gene.
An association between the rs1799853 and rs1057910 polymorphisms of CYP2C9, the rs4244285 polymorphism of CYP2C19 and the prevalence rates of drug-resistant epilepsy in children.
Antioxidants, enzyme induction, and chronic pancreatitis: a reappraisal following studies in patients on anticonvulsants.
Association of CYP2C9, CYP2A6, ACSM2A, and CPT1A gene polymorphisms with adverse effects of valproic acid in Chinese patients with epilepsy.
Association of polymorphisms of CYP2C9, CYP2C19, and ABCB1, and activity of P-glycoprotein with response to anti-epileptic drugs.
Associations between CYP3A4, CYP3A5 and SCN1A polymorphisms and carbamazepine metabolism in epilepsy: A meta-analysis.
Citalopram and Cannabidiol: In Vitro and In Vivo Evidence of Pharmacokinetic Interactions Relevant to the Treatment of Anxiety Disorders in Young People.
Clinical relevance of genetic polymorphism in CYP2C9 gene to pharmacodynamics and pharmacokinetics of phenytoin in epileptic patients: validatory pharmacogenomic approach to pharmacovigilance.
Combination treatment of epilepsy with ketogenic diet and concurrent pharmacological inhibition of cytochrome P450 2E1.
CYP1A2 genotype affects carbamazepine pharmacokinetics in children with epilepsy.
CYP2C9 (*2&*3) and CYP2C19 (*2&*3) polymorphisms among children with nonlesional epilepsy: a single-center study.
CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes and phenytoin adverse reactions correlation.
CYP2C9 polymorphisms in epilepsy: influence on phenytoin treatment.
CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy.
CYP3A5?3 and C3435T MDR1 Polymorphisms in Prognostication of Drug-Resistant Epilepsy in Children and Adolescents.
Cytochrome P450 in neurological disease.
Cytochrome P450-mediated estrogen catabolism therapeutic avenues in epilepsy.
Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms.
Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy.
Effects of EPHX1, SCN1A and CYP3A4 genetic polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy.
Effects of polymorphisms in six candidate genes on phenytoin maintenance therapy in Han Chinese patients.
Effects of UGT1A6, UGT2B7, and CYP2C9 genotypes on plasma concentrations of valproic acid in Chinese children with epilepsy.
Eslicarbazepine acetate and carotid intima-media thickness in epileptic patients.
Genetic contribution of CYP1A1 variant on treatment outcome in epilepsy patients: a functional and interethnic perspective.
Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy.
Genetic polymorphisms in sex hormone metabolizing genes and drug response in women with epilepsy.
Genetic polymorphisms of CYP3A5, CHRM2, and ZNF498 and their association with epilepsy susceptibility: a pharmacogenetic and case-control study.
Gephyrin and CYP2C9 Genetic Polymorphisms in Patients with Pharmacoresistant Epilepsy.
Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.
Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy.
Individualized phenytoin therapy for Japanese pediatric patients with epilepsy based on CYP2C9 and CYP2C19 genotypes.
Influence of age and co-medication on the steady-state pharmacokinetics of valproic acid in Tunisian patients with epilepsy.
Influence of genetic variants of CYP2D6, CYP2C9, CYP2C19 and CYP3A4 on antiepileptic drug metabolism in pediatric patients with refractory epilepsy.
Inhibitory effect of valproic acid on cytochrome P450 2C9 activity in epilepsy patients.
Liver enzyme induction and serum lipid levels after replacement of carbamazepine with oxcarbazepine.
Modulation of androgen and estrogen receptor expression by antiepileptic drugs and steroids in hippocampus of patients with temporal lobe epilepsy.
Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms.
Neurovascular Drug Biotransformation Machinery in Focal Human Epilepsies: Brain CYP3A4 Correlates with Seizure Frequency and Antiepileptic Drug Therapy.
Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.
Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells.
Pattern of P450 expression at the human blood-brain barrier: Roles of epileptic condition and laminar flow.
Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients.
Pharmacogenetic evaluation of ABCB1, Cyp2C9, Cyp2C19 and methylene tetrahydrofolate reductase polymorphisms in teratogenicity of anti-epileptic drugs in women with epilepsy.
Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation.
Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach.
Phenoconversion of CYP2C9 in epilepsy limits the predictive value of CYP2C9 genotype in optimizing valproate therapy.
Polymorphic cytochromes P450 and drugs used in psychiatry.
Possible role of CYP2C9 & CYP2C19 single nucleotide polymorphisms in drug refractory epilepsy.
Predictors of ovulatory failure in women with epilepsy.
Profound reduction in the tamoxifen active metabolite endoxifen in a patient on phenytoin for epilepsy compared with a CYP2D6 genotype matched cohort.
Reproductive dysfunction in women with epilepsy: antiepileptic drug effects on sex-steroid hormones.
Serum sex hormone levels after replacing carbamazepine with oxcarbazepine.
Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels.
The association between CYP 2C9 polymorphism and bone health.
The association of adjusted plasma valproic acid concentration with CYP2C9 gene polymorphism in patients with epilepsy: a systematic review and meta-analysis.
The Effect of Genetic Polymorphisms of Cytochrome P450 CYP2C9, CYP2C19, and CYP2D6 on Drug-Resistant Epilepsy in Turkish Children.
The effect of polymorphic metabolism enzymes on serum phenytoin level.
The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics.
The influence of cytochrome oxidase CYP2A6, CYP2B6, and CYP2C9 polymorphisms on the plasma concentrations of valproic acid in epileptic patients.
The influence of folate serum levels on depressive mood and mental processing in patients with epilepsy treated with enzyme-inducing anti-epileptic drugs.
The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy.
[Association between genetic polymorphisms of CYP2C19 and CYP2C9 and phenytoin serum concentration]
[Development of rapid genotyping methods for single nucleotide polymorphisms of cytochrome P450 2C9 (CYP2C9) and cytochrome P450 2C19 (CYP2C19) and their clinical application in pediatric patients with epilepsy].
[Epilepsy pharmacogenetics : science or fiction?].
Epilepsy, Generalized
Predictors of ovulatory failure in women with epilepsy.
Epilepsy, Temporal Lobe
Modulation of androgen and estrogen receptor expression by antiepileptic drugs and steroids in hippocampus of patients with temporal lobe epilepsy.
Epistaxis
Topical timolol for treatment of epistaxis in hereditary haemorrhagic telangiectasia associated with bradycardia: a look at CYP2D6 metabolising variants.
Erectile Dysfunction
Effects of Lemon and Seville Orange Juices on the Pharmacokinetic Properties of Sildenafil in Healthy Subjects.
Erectile dysfunction drugs altered the activities of antioxidant enzymes, oxidative stress and the protein expressions of some cytochrome P450 isozymes involved in the steroidogenesis of steroid hormones.
Fluvoxamine affects sildenafil kinetics and dynamics.
In men with erectile dysfunction, satisfaction with quality of erections correlates with erection hardness, treatment satisfaction, and emotional well-being.
The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study.
The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers.
[Pharmacokinetics and interactions of raltegravir]
Erythema
Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1.
Erythema Multiforme
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Esophageal Neoplasms
Association between CYP1A1 polymorphisms and esophageal cancer: a meta-analysis.
Association of CYP1A1 MspI polymorphism in the esophageal cancer risk: a meta-analysis in the Chinese population.
Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses.
Association Studies of CYP1A1 Exon7 Polymorphism and -GSTM1 Interaction with Esophageal Cancer Risk: a Meta-Analysis in the Chinese Population.
Associations between CYP1A1 and CYP2E1 polymorphisms and susceptibility to esophageal cancer in Chaoshan and Taihang areas of China.
Correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer among the Kazakh ethnic group in Xinjiang.
Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer.
CYP1A1 genetic polymorphisms and risk for esophageal cancer: a case-control study in central China.
CYP1A1 Msp1 T/C polymorphism in esophageal cancer: no association and risk modulation.
CYP1A1, CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus.
CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China.
CYP2E1 Rsa I/Pst I polymorphism and esophageal cancer risk: a meta-analysis based on 1,088 cases and 2,238 controls.
Cytochrome P450 1A1 (CYP1A1) polymorphism and susceptibility to esophageal cancer: an updated meta-analysis of 27 studies.
Cytochrome P450 1B1, a novel chemopreventive target for benzo[a]pyrene-initiated human esophageal cancer.
Cytochrome P450 2E1 RsaI/PstI polymorphism and risk of esophageal cancer: A meta-analysis of 17 case-control studies.
Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aerodigestive tract cancer in alcoholic caucasians.
Depentylation of [3H-pentyl]methyl-n-amylnitrosamine by rat esophageal and liver microsomes and by rat and human cytochrome P450 isoforms.
Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9).
Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions.
Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population.
Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population.
Genetic polymorphisms and esophageal cancer risk.
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
Genetic susceptibility to esophageal cancer due to CYP1A1 gene variant rs4646903 in tobacco addicted patients of Pashtun ethnicity: a case control study in Khyber Pakhtunkhwa province of Pakistan.
GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.
Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China.
Mechanisms of esophageal cancer development in Brazilians.
Meta-analysis of association studies of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese.
Phase I/II enzyme gene polymorphisms and esophageal cancer risk: a meta-analysis of the literature.
Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barrett's esophagus and esophageal carcinoma.
Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population.
Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China.
Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi'an.
Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P450 2E1.
Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.
Transcriptional activity of the tandem repeat polymorphism in the 5'-flanking region of the human CYP2E1 gene.
[Genetic polymorphisms of cytochrome P450 2E1 and glutathione S-transferase P1 and susceptibility to esophageal cancer]
[Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]
[Researches on the polymorphism of cytochrome P450 2A6]
[Study on the association of cytochrome P450 polymorphisms and the risk of esophageal cancer: a meta-analysis.]
Esophageal Squamous Cell Carcinoma
Association of combined CYP2E1 gene polymorphism with the risk for esophageal squamous cell carcinoma in Huai'an population, China.
Association of Genetic Variants of CYP2C19 and CYP2D6 with Esophageal Squamous Cell Carcinoma Risk in Northern India, Kashmir.
Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer.
CYP1A1 and CYP2E1 genotypes and risk of esophageal squamous cell carcinoma in a high-incidence region, Kashmir.
CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China.
CYP2C9 inhibits the invasion and migration of esophageal squamous cell carcinoma via downregulation of HDAC.
Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9).
Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review).
Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.
Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.
Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes.
[Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]
Esophagitis, Peptic
Cytochrome P450 2C19 polymorphism influences the preventive effect of lansoprazole on the recurrence of erosive reflux esophagitis.
Genetic polymorphisms of CYP2C19 and IL1B have no influence on esomeprazole treatment for mild erosive esophagitis.
Role of cytochrome P450 2C19 genetic polymorphisms in the therapeutic efficacy of omeprazole in Iranian patients with erosive reflux esophagitis.
Essential Hypertension
A Novel Polymorphism of the CYP19 Gene is Associated with Essential Hypertension in China.
Association of CYP2D6 and ADRB1 genes with hypotensive and antichronotropic action of betaxolol in patients with arterial hypertension.
Association of CYP3A5 Gene Polymorphisms and Amlodipine-Induced Peripheral Edema in Chinese Han Patients with Essential Hypertension.
Association of Cytochrome P450 2C9*3 and Angiotensin II Receptor 1 (1166A>C) Gene Polymorphisms With the Antihypertensive Effect of Irbesartan.
Associations between ADRB1 and CYP2D6 gene polymorphisms and the response to ?-blocker therapy in hypertension.
CYP2E1 gene promoter polymorphism -1293G>C increases the risk of essential hypertension in men with alcohol abuse.
Cytochrome P450 1A1 (CYP1A1) T6325C polymorphism might modulate essential hypertension-associated stroke risk.
Effects of genetic factors on the pharmacokinetics and pharmacodynamics of amlodipine in primary hypertensive patients.
Effects of polymorphism of the beta(1) adrenoreceptor and CYP2D6 on the therapeutic effects of metoprolol.
Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients.
Sex-specific role of CYP24A1 rs2762939 in the risk of essential hypertension based on the serum vitamin D and total renin concentrations.
The Association of ADRB1 and CYP2D6 Polymorphisms With Antihypertensive Effects and Analysis of Their Contribution to Hypertension Risk.
The CYP2C9 genotype predicts the blood pressure response to irbesartan: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA) trial.
The expression level of myocardial ?1-adrenergic receptor affects metoprolol antihypertensive effects: a novel mechanism for interindividual difference.
The influence of CYP2D6 phenotype on the clinical response of nebivolol in patients with essential hypertension.
Essential Tremor
Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor.
CYP2D6 polymorphism is not associated with essential tremor.
Esthesioneuroblastoma, Olfactory
[Esthesioneuroblastoma: a case report and literature review]
[Esthesioneuroblastoma: A single institution's experience and general literature review].
[Esthesioneuroblastoma].
Exanthema
Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash.
Etravirine: new drug. Multidrug-resistant HIV: another option.
Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs.
Polymorphisms of Drug-Metabolizing Enzymes and Transporters Contribute to the Individual Variations of Erlotinib Steady State Trough Concentration, Treatment Outcomes, and Adverse Reactions in Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer Patients.
Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer.
Exophthalmos
[EXOPHTHALMOS, EXCEPTIONAL REVELATORY SIGN OF A TUMOR OF THE OLFACTIVE PLACODE. ESTHESIONEUROEPITHELIOMA. HISTOLOGICAL RELATION OF THIS TUMOR TO NERVOUS RETINAL TUMORS.]
[Influence of CYP3A4, CYP3A5, and NR3C1 genes polymorphism on the effectiveness of glucocorticoid therapy in patients with endocrine ophthalmopathy].
Eye Diseases
Cancer Activation and Polymorphisms of Human Cytochrome P450 1B1.
Exome sequencing in developmental eye disease leads to identification of causal variants in GJA8, CRYGC, PAX6 and CYP1B1.
Neural crest derivatives in ocular development: discerning the eye of the storm.
Familial Primary Pulmonary Hypertension
Evaluation of drug-drug interaction potential of beraprost sodium mediated by P450 in vitro.
Fanconi Anemia
The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage.
Fascioliasis
Induction of drug metabolizing enzymes in the liver of rats infested with Fasciola hepatica.
The effects of fascioliasis on the activities of some drug-metabolizing enzymes in desert sheep liver.
Fatty Liver
Alcohol steatosis and cytotoxicity: The role of cytochrome P4502E1 and autophagy.
Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion.
Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis.
Chemical characteristics for optimizing CYP2E1 inhibition.
Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice.
Chronic Ethanol Consumption and Generation of Etheno-DNA Adducts in Cancer-Prone Tissues.
Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis.
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model.
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.
CYP2E1 and Oxidant Stress in Alcoholic and Non-Alcoholic Fatty Liver Disease.
CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis.
CYP2E1 potentiates toxicity in obesity and after chronic ethanol treatment.
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice.
Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1? in vivo.
Cytochrome P450 and liver diseases.
Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications.
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis.
Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver.
Defining a relationship between dietary fatty acids and the cytochrome P450 system in a mouse model of fatty liver disease.
Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.
Diet-induced non-alcoholic fatty liver disease affects expression of major cytochrome P450 genes in a mouse model.
Dietary carbohydrate intake plays an important role in preventing alcoholic fatty liver in the rat.
Dietary restriction of energy and sugar results in a reduction in human cytochrome P450 2E1 activity.
Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver.
Does steatohepatitis impair liver regeneration? A study in a dietary model of non-alcoholic steatohepatitis in rats.
Drugs and steatohepatitis.
Effect of a stilbene glycoside-rich extract from Polygoni Multiflori Radix on experimental non-alcoholic fatty liver disease based on principal component and orthogonal partial least squares discriminant analysis.
Effects of binge ethanol on lipid homeostasis and oxidative stress in a rat model of nonalcoholic fatty liver disease.
Etiopathogenesis of nonalcoholic steatohepatitis.
Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis.
Extracellular matrix and cytochrome P450 gene expression can distinguish steatohepatitis from steatosis in mice.
Gender differences in diet-induced steatotic disease in Cyp2b-null mice.
Gene expression on liver toxicity induced by administration of haloperidol in rats with severe fatty liver.
Genetic Association and Gene-Gene Interaction Reveal Genetic Variations in ADH1B, GSTM1 and MnSOD Independently Confer Risk to Alcoholic Liver Diseases in India.
Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.
Genetic polymorphisms of the hepatic pathways of fatty liver disease after living donor liver transplantation.
Genetic variations of superoxide dismutase 2 and cytochrome P450 2E1 in non-alcoholic steatohepatitis.
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis.
Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis.
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.
Hepatoprotective Effect of Seed Coat ofEuryale ferox Extract in Non-alcoholic Fatty Liver Disease Induced by High-fat Diet in Mice by Increasing IRs-1 and Inhibiting CYP2E1.
Identification of Compounds in Coleus forskohlii Extract Involved in the Induction of Hepatic CYP and Fatty Liver in Mice.
Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver.
Importance of genetic polymorphisms in liver transplantation outcomes.
Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation.
Induction of CYP2E1 in non-alcoholic fatty liver diseases.
Influence of inducers and inhibitors of cytochrome P450 on the hepatotoxicity of hydrazine in vivo.
Inhibition of cytochrome P4502E1 by chlormethiazole attenuated acute ethanol-induced fatty liver.
Kynurenine-Induced Aryl Hydrocarbon Receptor Signaling in Mice Causes Body Mass Gain, Liver Steatosis, and Hyperglycemia.
Lack of common mutation in the alfa-subunit of the mitochondrial trifunctional protein and the polymorphism of CYP2E1 in three Japanese women with acute fatty liver of pregnancy/HELLP syndrome.
Molecular basis for a functional role of cytochrome P450 2E1 in non-alcoholic steatohepatitis.
Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model.
Non-alcoholic steatohepatitis: impaired antipyrine metabolism and hypertriglyceridaemia may be clues to its pathogenesis.
Oxidative stress and regulation of anti-oxidant enzymes in cytochrome P4502E1 transgenic mouse model of non-alcoholic fatty liver.
Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis.
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients.
Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress.
Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts.
PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease.
Protective effects of saponins from the root of Platycodon grandiflorum against fatty liver in chronic ethanol feeding via the activation of AMP-dependent protein kinase.
Reduction in hepatic cytochrome P-450 is correlated to the degree of liver fat content in animal models of steatosis in the absence of inflammation.
Regulation of the cytochrome P450 epoxyeicosanoid pathway is associated with distinct histologic features in pediatric non-alcoholic fatty liver disease.
Relationship between genetic polymorphism of cytochrome P450IIE1 and fatty liver.
Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients.
Relevance of CYP2E1 to Non-alcoholic Fatty Liver Disease.
Reversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPAR?, SCD1, and osteopontin.
Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity.
Role of CYP2E1 in the pathogenesis of alcoholic liver disease: modifications by cAMP and ubiquitin-proteasome pathway.
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets.
Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women.
Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis.
Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice.
The CYP2E1 knockout delivers another punch: first ASH, now NASH. Alcoholic steatohepatitis. Nonalcoholic steatohepatitis.
The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease.
The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts.
The roles of ER stress and P450 2E1 in CCl(4)-induced steatosis.
Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition.
Toxicological Implications of Mitochondrial Localization of CYP2E1.
Transcriptional Repression of CYP3A4 by Increased miR-200a-3p and miR-150-5p Promotes Steatosis in vitro.
Validated liquid chromatography-tandem mass spectrometry method for determination of totally nine probe metabolites of cytochrome P450 enzymes and UDP-glucuronosyltransferases.
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models.
[Experimental study on inhibitory effect of Chinese herbal compound on hepatocyte cytochrome P450 II E1 expression in rat model of nonalcoholic fatty liver]
[Obesity and steatohepatitis. Histologic aspects]
Fatty Liver, Alcoholic
?-Imidazolyl-alkyl derivatives as new preclinical drug candidates for treating non-alcoholic steatohepatitis.
A new approach to drug therapy in non-alcoholic steatohepatitis (NASH).
Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion.
Chemical characteristics for optimizing CYP2E1 inhibition.
Correction: Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis.
CYP1A2 contributes to alcohol-induced abnormal lipid metabolism through the PTEN/AKT/SREBP-1c pathway.
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice.
Dietary carbohydrate intake plays an important role in preventing alcoholic fatty liver in the rat.
Does steatohepatitis impair liver regeneration? A study in a dietary model of non-alcoholic steatohepatitis in rats.
Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis.
Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis.
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis.
Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.
Pioglitazone, quercetin and hydroxy citric acid effect on cytochrome P450 2E1 (CYP2E1) enzyme levels in experimentally induced non alcoholic steatohepatitis (NASH).
Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium.
The CYP2E1 knockout delivers another punch: first ASH, now NASH. Alcoholic steatohepatitis. Nonalcoholic steatohepatitis.
The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.
The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat.
Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition.
Febrile Neutropenia
Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in Lebanese breast cancer patients: paving the way for OMICs in low and middle income countries.
Fetal Alcohol Spectrum Disorders
ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects.
Expression of CYP2E1 during embryogenesis and fetogenesis in human cephalic tissues: implications for the fetal alcohol syndrome.
Loop-Mediated Isothermal Amplification and Polymerase Chain Reaction Methods for Specific and Rapid Detection of Rhodococcus fascians.
Fetal Growth Retardation
A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction.
A polymorphism in the CYP17 gene and intrauterine fetal growth restriction.
Alterations of placental cytochrome P450 1A1 and P-glycoprotein in tobacco-induced intrauterine growth retardation in rats.
Association of maternal xenobiotic-metabolizing gene polymorphisms with risk of fetal growth restriction.
Binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to AH receptor in placentas from normal versus abnormal pregnancy outcomes.
Drinking water contaminants, gene polymorphisms, and fetal growth.
Growth retardation of fetal rats exposed to nicotine in utero: possible involvement of CYP1A1, CYP2E1, and P-glycoprotein.
Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression.
The Function of Cytochrome P450 1A1 Enzyme (CYP1A1) and Aryl Hydrocarbon Receptor (AhR) in the Placenta.
The impact of intrauterine growth restriction on cytochrome P450 enzyme expression and activity.
Fibroma
Activation of CncC pathway by ROS burst regulates cytochrome P450 CYP6AB12 responsible for ?-cyhalothrin tolerance in Spodoptera litura.
The expression of P450 genes mediating fenpropathrin resistance is regulated by CncC and Maf in Tetranychus cinnabarinus (Boisduval).
Transcription factors, CncC and Maf, regulate expression of CYP6BQ genes responsible for deltamethrin resistance in Tribolium castaneum.
Fibromyalgia
Development and validation of a chemical hydrolysis method for dextromethorphan and dextrophan determination in urine samples: application to the assessment of CYP2D6 activity in fibromyalgia patients.
Fibrosarcoma
Indigofera aspalathoides protection against 20-methylcholanthrene-induced experimental fibrosarcoma growth after transplantation in rats - role of xenobiotic drug metabolizing enzymes.
Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.
Focal Nodular Hyperplasia
CYP1A1 alleles in women with focal nodular hyperplasia of the liver (FNH).
Expression of xenobiotic and steroid hormone metabolizing enzymes in hepatocellular tumors of the non-cirrhotic liver.
Folic Acid Deficiency
Effects of folic acid supplementation on the pharmacokinetics and anticoagulant effect of warfarin: an open-label, prospective study of long-term administration in adults.
Follicular Cyst
Dominant bovine ovarian follicular cysts express increased levels of messenger RNAs for luteinizing hormone receptor and 3 beta-hydroxysteroid dehydrogenase delta(4),delta(5) isomerase compared to normal dominant follicles.
Foot Ulcer
Effects of Radix Astragali and Radix Rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms.
Fractures, Spontaneous
Femoral Osteomyelitis Presenting as a Pathologic Fracture in a 53 Year Old Male: A Rare Case Report.
Frontotemporal Dementia
Debrisoquine hydroxylase gene polymorphism frequencies in patients with amyotrophic lateral sclerosis.
Gallbladder Neoplasms
Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies.
Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population.
Carcinogen Metabolism Pathway and Tumor Suppressor Gene Polymorphisms and Gallbladder Cancer Risk in North Indians: A Hospital-Based Case-Control Study.
CYP1A1, GSTM1, GSTT1 and TP53 Polymorphisms and Risk of Gallbladder Cancer in Bolivians.
Effect of genetic predisposition on the risk of gallbladder cancer in Hungary.
Genetic polymorphisms of cytochrome P450 1A1 and risk of gallbladder cancer.
Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese.
Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China.
Gallstones
A radical view of gallstone aetiogenesis.
Association of genetic variants of xenobiotic and estrogen metabolism pathway (CYP1A1 and CYP1B1) with gallbladder cancer susceptibility.
Gastritis
GSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population.
Influence of CYP2C19 functional polymorphism on Helicobacter pylori eradication.
Gastritis, Atrophic
Frequent CYP1A1 expression in gastric cancers and their related lesions.
Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population.
Gastroesophageal Reflux
Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny.
Influence of cytochrome P450 2C19 genetic polymorphism and dosage of rabeprazole on accuracy of proton-pump inhibitor testing in Chinese patients with gastroesophageal reflux disease.
Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers.
[CLINICAL AND ENDOSCOPIC CHARACTERISTICS OF THE GASTRODUODENAL MUCOSAL LESIONS IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION WITH DIFFERENT BODY MASS STATUS].
[How to choose correct proton pump inhibitors to patients with GERD?]
Gastrointestinal Diseases
Effect of azole antifungals ketoconazole and fluconazole on the pharmacokinetics of dexloxiglumide.
Ranolazine: new drug. Stable angina: not worth the risk.
Why oral opioids may not be effective in a subset of chronic pain patients.
Gastrointestinal Neoplasms
Extrahepatic cytochrome P450 epoxygenases: pathophysiology and clinical significance in human gastrointestinal cancers.
RsaI but not DraI polymorphism in CYP2E1 gene increases the risk of gastrointestinal cancer in Malaysians: a case-control study.
Small intestinal cytochromes P450.
Gastrointestinal Stromal Tumors
Biliary excretion of imatinib mesylate and its metabolite CGP 74588 in humans.
Disposition of imatinib and its metabolite CGP74588 in a patient with chronic myelogenous leukemia and short-bowel syndrome.
Genetic polymorphisms in ABCG2 and CYP1A2 are associated with imatinib dose reduction in patients treated for gastrointestinal stromal tumors.
Influence of CYP2C8 polymorphisms on imatinib steady-state trough level in chronic myeloid leukemia and gastrointestinal stromal tumor patients.
Influence of Cytochrome P450, ABC and SLC Gene Polymorphisms on Imatinib Therapy Outcome of Patients with Gastrointestinal Stromal Tumours (GIST).
Sunitinib: new drug. For some gastrointestinal stromal tumours.
Gastroparesis
Review article: metoclopramide and tardive dyskinesia.
Gaucher Disease
A pooled analysis of adverse events in 393 adults with Gaucher disease type 1 from four clinical trials of oral eliglustat: Evaluation of frequency, timing, and duration.
Allelic and phenotypic characterization of CYP2D6 and its encoded P450 cytochrome enzyme in a serie of Spanish type 1 Gaucher disease patients.
Clinical response to eliglustat in treatment-naïve patients with Gaucher disease type 1: Post-hoc comparison to imiglucerase-treated patients enrolled in the International Collaborative Gaucher Group Gaucher Registry.
Comorbidities and pharmacotherapies in patients with Gaucher disease type 1: The potential for drug-drug interactions.
Effects of paroxetine, ketoconazole, and rifampin on the metabolism of eliglustat, an oral substrate reduction therapy for Gaucher disease type 1.
Eliglustat: A Review in Gaucher Disease Type 1.
How a concentration-effect analysis of data from the eliglustat thorough electrocardiographic study was used to support dosing recommendations.
Impact of hepatic and renal impairment on the pharmacokinetics and tolerability of eliglustat therapy for Gaucher disease type 1.
Long-term adverse event profile from four completed trials of oral eliglustat in adults with Gaucher disease type 1.
Management and monitoring recommendations for the use of eliglustat in adults with type 1 Gaucher disease in Europe.
Metabolizing profile of the cytochrome pathway CYP2D6, CYP3A4 and the ABCB 1 transporter in Spanish patients affected by Gaucher disease.
Outcomes after 18 Months of Eliglustat Therapy in Treatment-Naïve Adults with Gaucher Disease Type 1: The Phase 3 ENGAGE Trial.
Genetic Diseases, Inborn
25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D.
Cerebrotendinous Xanthomatosis ataxia responsive to CDCA and Riluzole.
CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions.
Disposition of drugs in cystic fibrosis. V. In vivo CYP2C9 activity as probed by (S)-warfarin is not enhanced in cystic fibrosis.
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
In Search of New Therapeutics-Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond.
Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat.
Towards Accurate Genotype-Phenotype Correlations in the CYP2D6 Gene.
Genital Diseases, Female
Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk.
Gilbert Disease
Correction of venlafaxine- and duloxetine-induced transaminase elevations with desvenlafaxine in a patient with Gilbert's syndrome.
Disposition of propafenone in a poor metabolizer of CYP2D6 with Gilbert's syndrome.
Effect of cimetidine on the metabolism of cholephilic dyes in Gilbert's syndrome.
Gingival Hyperplasia
Association of galactose single-point test levels and phenytoin metabolic polymorphisms with gingival hyperplasia in patients receiving long-term phenytoin therapy.
Gingival Hypertrophy
CYP2C9 polymorphisms in epilepsy: influence on phenytoin treatment.
Gingival Overgrowth
How genetic variation was analyzed in phenytoin-induced gingival enlargement using single-nucleotide polymorphism of candidate gene CYP2C9?
Glaucoma
A Case of 22q11.2 Deletion Syndrome with Peters Anomaly, Congenital Glaucoma, and Heterozygous Mutation in CYP1B1.
A clinical and molecular genetic study of German patients with primary congenital glaucoma.
A clinical and molecular genetics study of primary congenital glaucoma in South Korea.
A compound heterozygous change found in Peters' anomaly.
A Novel CYP1B1 Mutation with Congenital Glaucoma and Total Aniridia.
A novel frameshift founder mutation in the cytochrome P450 1B1 (CYP1B1) gene is associated with primary congenital glaucoma in Morocco.
A novel methodology for enhanced and consistent heterologous expression of unmodified human cytochrome P450 1B1 (CYP1B1).
A novel truncating mutation of cytochrome P4501B1 (CYP1B1) gene in primary infantile glaucoma.
A polymorphism in the CYP1B1 promoter is functionally associated with primary congenital glaucoma.
A spectrum of CYP1B1 mutations associated with primary congenital glaucoma in families of Pakistani descent.
An integrative data mining approach to identifying adverse outcome pathway signatures.
Analysis of CYP1B1 sequence alterations in patients with primary open-angle glaucoma of Saudi origin.
Angiopoietin receptor TEK interacts with CYP1B1 in primary congenital glaucoma.
Anterior segment development relevant to glaucoma.
Axenfeld-Rieger Syndrome Associated with Congenital Glaucoma and Cytochrome P4501B1 Gene Mutations.
Biallelic CPAMD8 Variants Are a Frequent Cause of Childhood and Juvenile Open-Angle Glaucoma.
Bioinformatics analysis of CYP1B1 mutation hotspots in Chinese primary congenital glaucoma patients.
Candidate Gene Analysis Identifies Mutations in CYP1B1 and LTBP2 in Indian Families with Primary Congenital Glaucoma.
Carrier frequency of CYP1B1 mutations in the United States (an American Ophthalmological Society thesis).
Cataract extraction in patients with primary congenital glaucoma.
Characterization of the biochemical and structural phenotypes of four CYP1B1 mutations observed in individuals with primary congenital glaucoma.
Clinical application of NGS-based SNP haplotyping for the preimplantation genetic diagnosis of primary open angle glaucoma.
Clinical variability of CYP1B1 gene variants in Pakistani primary congenital glaucoma families.
Clinical Variability of Primary Congenital Glaucoma in a Spanish Family With Cyp1b1 Gene Mutations.
Complex genetic mechanisms in glaucoma: an overview.
Complex genetics of glaucoma: defects in CYP1B1, and not MYOC, cause pathogenesis in an early-onset POAG patient with double variants at both loci.
Compound heterozygous mutations in CYP1B1 gene leads to severe primary congenital glaucoma phenotype.
Congenital glaucoma and CYP1B1: an old story revisited.
Congenital Glaucoma: CYP1B1 Mutations in Israeli Bedouin Kindreds.
Contribution of CYP1B1 mutations and founder effect to primary congenital glaucoma in Mexico.
Contributions of MYOC and CYP1B1 mutations to JOAG.
Corneal enlargement without optic disk cupping in children with recessive CYP1B1 mutations.
Correlations of genotype with phenotype in Indian patients with primary congenital glaucoma.
CYP1B1 analysis of unilateral primary newborn glaucoma in Saudi children.
CYP1B1 and MYOC mutations in 116 Chinese patients with primary congenital glaucoma.
CYP1B1 and MYOC Mutations in Vietnamese Primary Congenital Glaucoma Patients.
CYP1B1 and MYOC variants in neonatal-onset versus infantile-onset primary congenital glaucoma.
CYP1B1 copy number variation is not a major contributor to primary congenital glaucoma.
CYP1B1 Cytopathy: Uncommon Phenotype of a Homozygous CYP1B1 Deletion as Internal Corneal Ulcer of Von Hippel.
CYP1B1 gene analysis and phenotypic correlation in Portuguese children with primary congenital glaucoma.
CYP1B1 Gene Analysis in Primary Congenital Glaucoma Brazilian Patients: Novel Mutations and Association With Poor Prognosis.
CYP1B1 gene analysis in primary congenital glaucoma in Indonesian and European patients.
CYP1B1 Gene and Phenotypic Correlation in Patients From Northeastern Brazil With Primary Congenital Glaucoma.
CYP1B1 gene mutations causing primary congenital glaucoma in Tunisia.
CYP1B1 gene mutations with incomplete penetrance in a Chinese pedigree with primary congenital glaucoma: a case report and review of literatures.
CYP1B1 gene: Implications in glaucoma and cancer.
CYP1B1 genotype influences the phenotype in primary congenital glaucoma and surgical treatment.
Cyp1b1 Mediates Periostin Regulation of Trabecular Meshwork Development by Suppression of Oxidative Stress.
CYP1B1 mutation profile of Iranian primary congenital glaucoma patients and associated haplotypes.
CYP1B1 mutational screening in a Portuguese cohort of primary congenital glaucoma patients.
CYP1B1 Mutations are a Major Contributor to Juvenile-Onset Open Angle Glaucoma in Saudi Arabia.
CYP1B1 mutations in French patients with early-onset primary open-angle glaucoma.
CYP1B1 Mutations in Individuals With Primary Congenital Glaucoma and Residing in Denmark.
CYP1B1 mutations in patients with primary congenital glaucoma from Saudi Arabia.
CYP1B1 mutations in Spanish patients with primary congenital glaucoma: phenotypic and functional variability.
Cyp1b1 Regulates Ocular Fissure Closure Through a Retinoic Acid-Independent Pathway.
CYP1B1, a developmental gene with a potential role in glaucoma therapy.
CYP1B1, MYOC, and LTBP2 mutations in primary congenital glaucoma patients in the United States.
CYP1B1-mediated Pathobiology of Primary Congenital Glaucoma.
CYP1B1-Related Anterior Segment Developmental Anomalies Novel Mutations for Infantile Glaucoma and Von Hippel's Ulcer Revisited.
CYP1B1: A key regulator of redox homeostasis.
Cytochrome oxidase 2D6 gene polymorphism in primary open-angle glaucoma with various effects to ophthalmic timolol.
Cytochrome P450 1B1 and Primary Congenital Glaucoma.
Cytochrome P450 1B1 gene mutations in Japanese patients with primary congenital glaucoma(1).
Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene.
Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene.
Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.
Disease gene candidates revealed by expression profiling of retinal ganglion cell development.
Disease-causing mutations in proteins: structural analysis of the CYP1B1 mutations causing primary congenital glaucoma in humans.
Effect of two mutations of human CYP1B1, G61E and R469W, on stability and endogenous steroid substrate metabolism.
Embryonic expression of the optineurin (glaucoma) gene in different stages of mouse development.
Evaluation of the CYP1B1 gene as a candidate gene in beagles with primary open-angle glaucoma (POAG).
Exome Sequencing in a Swiss Childhood Glaucoma Cohort Reveals CYP1B1 and FOXC1 Variants as Most Frequent Causes.
Expanding the clinical spectrum of COL1A1 mutations in different forms of glaucoma.
Expression of cytochrome P450 (CYP) enzymes in human non-pigmented ciliary epithelial cells; induction of CYP1B1 expression by TCDD.
Expression of cytochrome P4501b1 (Cyp1b1) during early murine development.
Familial juvenile glaucoma with underlying homozygous p.G61E CYP1B1 mutations.
Founder mutations of CYP1B1 gene in patients with congenital glaucoma from the United States and Brazil.
Functional and Structural Analyses of CYP1B1 Variants Linked to Congenital and Adult-Onset Glaucoma to Investigate the Molecular Basis of These Diseases.
Functional characterization of eight rare missense CYP1B1 variants involved in congenital glaucoma and their association with null genotypes.
Further support of the role of CYP1B1 in patients with Peters anomaly.
Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.
Gene symbol: CYP1B1. Disease: glaucoma, primary congenital.
Gene symbol: CYP1B1. Disease: Glaucoma, primary congenital. Accession #Hd0513.
Gene symbol: CYP1B1. Disease: glaucoma, primary congenital. Accession #Hm0541.
Gene symbol: CYP1B1. Disease: Primary congenital glaucoma. Accession #Hd0515.
Gene symbol: CYP1B1. Disease: Primary congenital glaucoma. Accession #Hm0544.
Generation of a human iPSC line from a patient with congenital glaucoma caused by mutation in CYP1B1 gene.
Genetic basis of glaucoma.
Genetic heterogeneity and minor CYP1B1 involvement in the molecular basis of primary congenital glaucoma in Gypsies.
Genetic homogeneity for inherited congenital microcoria loci in an Asian Indian pedigree.
Genetics and biochemistry of primary congenital glaucoma.
Genotype and phenotype correlations in congenital glaucoma.
Genotype and phenotype correlations in congenital glaucoma: CYP1B1 mutations, goniodysgenesis, and clinical characteristics.
Genotype-phenotype correlation in Moroccan patients with primary congenital glaucoma.
Genotype/phenotype correlation in primary congenital glaucoma patients from different ethnic groups of the Israeli population.
Genotype/Phenotype Correlation in Primary Congenital Glaucoma Patients in the Lebanese Population: A Pilot Study.
Glaucoma genetics: where are we? Where will we go?
Glaucoma in Costa Rica. Initial approaches.
Glaucoma in iran and contributions of studies in iran to the understanding of the etiology of glaucoma.
Glaucoma-associated CYP1B1 mutations share similar haplotype backgrounds in POAG and PACG phenotypes.
Globally, CYP1B1 mutations in primary congenital glaucoma are strongly structured by geographic and haplotype backgrounds.
Goniodysgenesis variability and activity of CYP1B1 genotypes in primary congenital glaucoma.
Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma.
Heterozygous loss of function variants in CYP1B1 predispose to primary open angle glaucoma.
High diagnostic yield of clinically unidentifiable syndromic growth disorders by targeted exome sequencing.
Homozygous p.G61E mutation in a consanguineous Pakistani family with co-existence of juvenile-onset open angle glaucoma and primary congenital glaucoma.
Identification of a single ancestral CYP1B1 mutation in Slovak Gypsies (Roms) affected with primary congenital glaucoma.
Identification of novel CYP1B1 gene mutations in patients with primary congenital and primary open-angle glaucoma.
Identification of novel mutations causing familial primary congenital glaucoma in Indian pedigrees.
Identification of R368H as a predominant CYP1B1 allele causing primary congenital glaucoma in Indian patients.
Identities and frequencies of variants in CYP1B1 causing primary congenital glaucoma in Pakistan.
Immunolocalization of CYP1B1 in normal, human, fetal and adult eyes.
In silico analysis of five missense mutations in CYP1B1 gene in Pakistani families affected with primary congenital glaucoma.
Investigating Genetic Factors Contributing to Variable Expressivity of Class I 17p13.3 Microduplication.
Investigation of CYP1B1 Gene Involvement in Primary Congenital Glaucoma in Iraqi Children.
Investigation of CYP1B1 mutations in Chinese patients with primary congenital glaucoma.
Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis.
Leu432Val polymorphism in CYP1B1 as a susceptible factor towards predisposition to primary open-angle glaucoma.
Meta-analysis of CYP1B1 gene mutations in primary congenital glaucoma patients.
Modification of ocular defects in mouse developmental glaucoma models by tyrosinase.
Molecular analysis of CYP1B1 in Omani patients with primary congenital glaucoma: a pilot study.
Molecular analysis of Italian patients with congenital glaucoma.
Molecular analysis of the CYP1B1 gene: identification of novel truncating mutations in patients with primary congenital glaucoma.
Molecular and clinical evaluation of primary congenital glaucoma in kuwait.
Molecular basis for involvement of CYP1B1 in MYOC upregulation and its potential implication in glaucoma pathogenesis.
Molecular characterisation of congenital glaucoma in a consanguineous Canadian community: a step towards preventing glaucoma related blindness.
Molecular characterization of Axenfeld-Rieger spectrum and other anterior segment dysgeneses in a sample of Mexican patients.
Molecular Characterization Of Newborn Glaucoma Including A Distinct Aniridic Phenotype.
Molecular genetics of primary congenital glaucoma in Brazil.
Multiple CYP1B1 mutations and incomplete penetrance in an inbred population segregating primary congenital glaucoma suggest frequent de novo events and a dominant modifier locus.
Mutation analysis of seven known glaucoma-associated genes in Chinese patients with glaucoma.
Mutation spectrum of CYP1B1 and MYOC genes in Korean patients with primary congenital glaucoma.
Mutation spectrum of CYP1B1 in North Indian congenital glaucoma patients.
Mutation spectrum of the CYP1B1 gene for congenital glaucoma in the Japanese population.
Mutation spectrum of the CYP1B1 gene in Indian primary congenital glaucoma patients.
Mutational analysis of CYP1B1 gene in Iranian pedigrees with glaucoma reveals known and novel mutations.
Mutational analysis of the CYP1B1 gene in Pakistani primary congenital glaucoma patients: Identification of four known and a novel causative variant at the 3' splice acceptor site of intron 2.
Mutational spectrum of the CYP1B1 gene in Iranain primary congenital glaucoma family.
Mutational spectrum of the CYP1B1 gene in Pakistani patients with primary congenital glaucoma: novel variants and genotype-phenotype correlations.
Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme.
Mutations in CYP1B1, the gene for cytochrome P4501B1, are the predominant cause of primary congenital glaucoma in Saudi Arabia.
MYOC and FOXC1 gene analysis in primary congenital glaucoma.
Myocilin gene implicated in primary congenital glaucoma.
Novel compound heterozygous mutations in CYP1B1 identified in a Chinese family with developmental glaucoma.
Novel CYP1B1 and known PAX6 mutations in anterior segment dysgenesis (ASD).
Novel CYP1B1 mutations and a possible prognostic use for surgical management of congenital glaucoma.
Novel CYP1B1 mutations in consanguineous Pakistani families with primary congenital glaucoma.
Novel cytochrome P450 1B1 (CYP1B1) mutations in patients with primary congenital glaucoma in France.
Novel cytochrome P4501B1 (CYP1B1) gene mutations in Japanese patients with primary congenital glaucoma.
Novel Homozygous CYP1B1 Deletion in Siblings with Primary Congenital Glaucoma.
Null cyp1b1 Activity in Zebrafish Leads to Variable Craniofacial Defects Associated with Altered Expression of Extracellular Matrix and Lipid Metabolism Genes.
Null CYP1B1 Genotypes in Primary Congenital and Nondominant Juvenile Glaucoma.
Occurrence of MYOC and CYP1B1 variants in juvenile open angle glaucoma Brazilian patients.
Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition.
Overview of Cytochrome P450 1B1 gene mutations in patients with primary congenital glaucoma.
P.Gly61Glu and P.Arg368His Mutations in CYP1B1 that Cause Congenital Glaucoma may be Relatively Frequent in Certain Regions of Gilan Province, Iran.
Phenotype and Genotype Correlation in Iranian Primary Congenital Glaucoma Patients.
Phylogenetic evaluation of the CYP1B1 gene in patients with primary congenital glaucoma.
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Prevalence of CYP1B1 mutations in Australian patients with primary congenital glaucoma.
Primary congenital glaucoma and Rieger's anomaly: extended haplotypes reveal founder effects for eight distinct CYP1B1 mutations.
Primary Congenital Glaucoma and the Involvement of CYP1B1.
Primary congenital glaucoma caused by the homozygous F261L CYP1B1 mutation and paternal isodisomy of chromosome 2.
Primary congenital glaucoma due to paternal uniparental isodisomy of chromosome 2 and CYP1B1 deletion.
Primary congenital glaucoma in Vietnam: analysis and identification of novel CYP1B1 variants.
Primary congenital glaucoma: a novel single-nucleotide deletion and varying phenotypic expression for the 1,546-1,555dup mutation in the GLC3A (CYP1B1) gene in 2 families of different ethnic origin.
Primary congenital glaucoma: three case reports on novel mutations and combinations of mutations in the GLC3A (CYP1B1) gene.
Primary role of CYP1B1 in Indian juvenile-onset POAG patients.
Progress in the genetics of glaucoma.
Research progress on human genes involved in the pathogenesis of glaucoma (Review).
Role of CYP1B1 in glaucoma.
Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients.
Roles of cytochrome p450 in development.
Screening Glaucoma Genes in Adult Glaucoma suggests a multiallelic contribution of CYP1B1 to Open Angle Glaucoma Phenotypes.
Screening of common CYP1B1 mutations in Iranian POAG patients using a microarray-based PrASE protocol.
Screening of CYP1B1 and LTBP2 genes in Saudi families with primary congenital glaucoma: genotype-phenotype correlation.
Screening of CYP1B1 and MYOC in Moroccan families with primary congenital glaucoma: three novel mutations in CYP1B1.
Screening of CYP1B1 Arg368His as predominant mutation in North Indian primary open angle glaucoma and juvenile onset glaucoma patients.
Screening of the LTBP2 gene in 214 Chinese sporadic CYP1B1-negative patients with primary congenital glaucoma.
Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of juvenile glaucoma with goniodysgenesis.
Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia.
Sex Bias in Primary Congenital Glaucoma Patients with and without CYP1B1 Mutations.
Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiol.
Single nucleotide polymorphism of MYOC affected the severity of primary open angle glaucoma.
Structural assessment of PITX2, FOXC1, CYP1B1, and GJA1 genes in patients with Axenfeld-Rieger syndrome with developmental glaucoma.
Sturge-Weber Syndrome With Congenital Glaucoma and Cytochrome P450 (CYP1B1) Gene Mutations.
Survey of familial glaucoma shows a high incidence of cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) mutations in non-consanguineous congenital forms in a Spanish population.
Tag SNPs detect association of the CYP1B1 gene with primary open angle glaucoma.
Targeted deletion of Cyp1b1 in pericytes results in attenuation of retinal neovascularization and trabecular meshwork dysgenesis.
Targeted Screening for Predominant CYP1B1 Mutations in Primary Congenital Glaucoma.
The Identification and Stereochemistry Analysis of a Novel Mutation p.(D367Tfs*61) in the CYP1B1 Gene: A Case Report.
The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu).
The p.Gly61Glu Mutation in CYP1B1 Affects the Extracellular Matrix in Glaucoma Patients.
The TIGR gene, pathogenic mechanisms, and other recent advances in glaucoma genetics.
The transcription factor gene FOXC1 exhibits a limited role in primary congenital glaucoma.
Two novel variants in CYP1B1 gene: a major contributor of autosomal recessive primary congenital glaucoma with allelic heterogeneity in Pakistani patients.
Ultrastructural Abnormalities of the Trabecular Meshwork Extracellular Matrix in Cyp1b1-Deficient Mice.
Unusual Association of Aniridia with Aicardi-Goutières Syndrome-Related Congenital Glaucoma in a Tertiary Care Center.
Variable Expressivity and High Penetrance of CYP1B1 Mutations Associated with Primary Congenital Glaucoma.
Whole exome sequencing identifies multiple diagnoses in congenital glaucoma with systemic anomalies.
[A novel mutation of CYP1B1 gene in primary congenital glaucoma]
[Analysis of the CYP1B1 gene mutation in primary congenital glaucoma patients of Hubei Han nationality]
[Coding sequence analysis of CYP1B1 exon III in the Polish population of patients with primary congenital and juvenile glaucoma]
[Construction of CYP1B1 gene haplotypes predisposing to primary congenital glaucoma through allele-specific PCR/restriction fragment length polymorphism analysis].
[From congenital glaucoma to chronic open angle glaucoma in adulthood: a clinical and genetic continuum].
[Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg]
[Homozygous E387K (1159G>A) mutation of the CYP1B1 gene in a Roma boy affected with primary congenital glaucoma. Case report].
[Mendelian molecular genetics in glaucoma].
[Two variants in MYOC and CYP1B1 genes in a Chinese family with primary angle-closure glaucoma.]
Glaucoma, Angle-Closure
A polymorphism in the CYP1B1 promoter is functionally associated with primary congenital glaucoma.
Association of eNOS polymorphisms with primary angle-closure glaucoma.
[Two variants in MYOC and CYP1B1 genes in a Chinese family with primary angle-closure glaucoma.]
Glaucoma, Open-Angle
A novel MYOC heterzygous mutation identified in a Chinese Uygur pedigree with primary open-angle glaucoma.
A polymorphism in the CYP1B1 promoter is functionally associated with primary congenital glaucoma.
Analysis of CYP1B1 sequence alterations in patients with primary open-angle glaucoma of Saudi origin.
Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma.
Association of a common coding polymorphism (N453S) of the cytochrome P450 1B1 (CYP1B1) gene with optic disc cupping and visual field alteration in French patients with primary open-angle glaucoma.
Association of single nucleotide polymorphisms in the CYP1B1 gene with the risk of primary open-angle glaucoma: a meta-analysis.
Biallelic CPAMD8 Variants Are a Frequent Cause of Childhood and Juvenile Open-Angle Glaucoma.
Clinical application of NGS-based SNP haplotyping for the preimplantation genetic diagnosis of primary open angle glaucoma.
Complex genetic mechanisms in glaucoma: an overview.
Contributions of MYOC and CYP1B1 mutations to JOAG.
CYP1B1 Mutations are a Major Contributor to Juvenile-Onset Open Angle Glaucoma in Saudi Arabia.
CYP1B1 mutations in French patients with early-onset primary open-angle glaucoma.
Detection of mutations in MYOC, OPTN, NTF4, WDR36 and CYP1B1 in Chinese juvenile onset open-angle glaucoma using exome sequencing.
Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene.
Evaluation of the CYP1B1 gene as a candidate gene in beagles with primary open-angle glaucoma (POAG).
Functional analysis of CYP1B1 mutations and association of heterozygous hypomorphic alleles with primary open-angle glaucoma.
Functional and Structural Analyses of CYP1B1 Variants Linked to Congenital and Adult-Onset Glaucoma to Investigate the Molecular Basis of These Diseases.
Gene expression profiles of human trabecular meshwork cells induced by triamcinolone and dexamethasone.
Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma.
Heterozygous loss of function variants in CYP1B1 predispose to primary open angle glaucoma.
Identification of novel CYP1B1 gene mutations in patients with primary congenital and primary open-angle glaucoma.
Leu432Val polymorphism in CYP1B1 as a susceptible factor towards predisposition to primary open-angle glaucoma.
Molecular basis for involvement of CYP1B1 in MYOC upregulation and its potential implication in glaucoma pathogenesis.
Mutation spectrum of CYP1B1 in Chinese patients with primary open-angle glaucoma.
Mutation spectrum of the CYP1B1 gene for congenital glaucoma in the Japanese population.
Mutations in the CYP1B1 gene may contribute to juvenile-onset open-angle glaucoma.
Myocilin gene implicated in primary congenital glaucoma.
No association of genetic polymorphisms in CYP1B1 with primary open-angle glaucoma: a meta- and gene-based analysis.
Occurrence of CYP1B1 Mutations in Juvenile Open-Angle Glaucoma With Advanced Visual Field Loss.
Occurrence of MYOC and CYP1B1 variants in juvenile open angle glaucoma Brazilian patients.
Primary role of CYP1B1 in Indian juvenile-onset POAG patients.
Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients.
Role of CYP1B1, p.E229K and p.R368H mutations among 120 families with sporadic juvenile onset open-angle glaucoma.
Roles of CYP2C19 Gene Polymorphisms in Susceptibility to POAG and Individual Differences in Drug Treatment Response.
Screening Glaucoma Genes in Adult Glaucoma suggests a multiallelic contribution of CYP1B1 to Open Angle Glaucoma Phenotypes.
Screening of common CYP1B1 mutations in Iranian POAG patients using a microarray-based PrASE protocol.
Screening of CYP1B1 Arg368His as predominant mutation in North Indian primary open angle glaucoma and juvenile onset glaucoma patients.
Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of primary open-angle glaucoma.
Single nucleotide polymorphism of MYOC affected the severity of primary open angle glaucoma.
Tag SNPs detect association of the CYP1B1 gene with primary open angle glaucoma.
The p.Gly61Glu Mutation in CYP1B1 Affects the Extracellular Matrix in Glaucoma Patients.
[From gene to disease; primary open-angle glaucoma and three known genes: MYOC, CYP1B1 and OPTN]
[Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg]
Glioblastoma
Antiangiogenic effect of inhibitors of cytochrome P450 on rats with glioblastoma multiforme.
Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target.
Dopamine is an aryl hydrocarbon receptor agonist.
Glutathione S-Transferases and Cytochrome P450 Enzyme Expression in Patients with Intracranial Tumors: Preliminary Report of 55 Patients.
Human metastable epiallele candidates link to common disorders.
MGMT- and P450 3A-inhibitors do not sensitize glioblastoma cell cultures against nitrosoureas.
miR-204 functions as a tumor suppressor gene, at least partly by suppressing CYP27A1 in glioblastoma.
P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy.
Primary neural stem/progenitor cells expressing endostatin or cytochrome P450 for gene therapy of glioblastoma.
Rabbit cytochrome P450 4B1: A novel prodrug activating gene for pharmacogene therapy of hepatocellular carcinoma.
Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential.
Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system.
[Apoptosis and differentiation induced with TCLA in rat glioblastoma cells in vitro]
Glioma
?-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function.
A population-based case-control study of the CYP2D6 and GSTT1 polymorphisms and malignant brain tumors.
ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.
Accumulation of mitochondrial P450MT2, NH(2)-terminal truncated cytochrome P4501A1 in rat brain during chronic treatment with beta-naphthoflavone. A role in the metabolism of neuroactive drugs.
Amplification and expression of splice variants of the gene encoding the P450 cytochrome 25-hydroxyvitamin D(3) 1,alpha-hydroxylase (CYP 27B1) in human malignant glioma.
An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors.
Augmentation of chemotherapy-triggered glioma cell apoptosis by blockade of arachidonic acid metabolism-the potential role of ceramide accumulation.
CYP19 expression is induced by 2,3,7,8-tetrachloro-dibenzo-para-dioxin in human glioma cells.
CYP2C9 polymorphisms in human tumors.
Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target.
Effect of Nicotine on CYP2B1 Expression in a Glioma Animal Model and Analysis of CYP2B6 Expression in Pediatric Gliomas.
Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene.
Expression and induction of cytochrome P-450 1A1 and P-450 2D subfamily in the rat glioma C6 cell line.
Expression, induction and regulation of the cytochrome P450 monooxygenase system in the rat glioma C6 cell line.
Gene therapy for malignant gliomas using replication incompetent retroviral and adenoviral vectors encoding the cytochrome P450 2B1 gene together with cyclophosphamide.
Genetic polymorphisms in glutathione S-transferase mu and theta, N-acetyltransferase, and CYP1A1 and risk of gliomas.
Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors.
Glutamate affects the CYP1B1- and CYP2U1-mediated hydroxylation of arachidonic acid metabolism via astrocytic mGlu5 receptor.
Glutathione S-transferases and cytochrome P450 detoxifying enzyme distribution in human cerebral glioma.
Identification of cytochrome P450s in human glioma cell line.
Identification of cytochromes P450 1A2, 2A1, 2C7, 2E1 in rat glioma C6 cell line by RT-PCR and specific restriction enzyme digestion.
Identification of inducible mixed function oxidase system in rat glioma C6 cell line.
Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1.
Novel Functional Association of Serine Palmitoyltransferase Subunit 1-A Peptide in Sphingolipid Metabolism with Cytochrome P4501A1 Transactivation and Proliferative Capacity of the Human Glioma LN18 Brain Tumor Cell Line.
P450 enzyme-inducing and non-enzyme-inducing antiepileptic drugs for seizure prophylaxis after glioma resection surgery: a meta-analysis.
Perioperative levetiracetam for prevention of seizures in supratentorial brain tumor surgery.
Phase I/II trial of pyrazoloacridine and carboplatin in patients with recurrent glioma: a North Central Cancer Treatment Group trial.
Physiological role of the N-terminal processed P4501A1 targeted to mitochondria in erythromycin metabolism and reversal of erythromycin-mediated inhibition of mitochondrial protein synthesis.
Prodrug-activating Gene Therapy with Rabbit Cytochrome P450 4B1/4-Ipomeanol or 2-Aminoanthracene System in Glioma Cells.
The aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl induces distinct patterns of gene expression between hepatoma and glioma cells: chromatin remodeling as a mechanism for selective effects.
The Role of Aryl Hydrocarbon Receptor-Regulated Cytochrome P450 Enzymes in Glioma.
Towards a complete picture of splice variants of the gene for 25-hydroxyvitamin D31alpha-hydroxylase in brain and skin cancer.
Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen.
Gliosarcoma
Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy.
Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells.
Enantioselective metabolism and cytotoxicity of R-Ifosfamide and S-Ifosfamide by tumor cell-expressed cytochromes P450.
Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11.
Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model.
Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy.
Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors.
Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene.
Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy.
Glomerulonephritis, Membranous
Clinical observation on the effect of Wuzhi soft capsule on FK506 concentration in membranous nephropathy patients.
Cytochrome P450 2B1 mediates complement-dependent sublytic injury in a model of membranous nephropathy.
Effects of CYP3A5 Polymorphisms on Efficacy and Safety of Tacrolimus Therapy in Patients with Idiopathic Membranous Nephropathy.
Glucose Intolerance
CYP1B1 deficiency ameliorates obesity and glucose intolerance induced by high fat diet in adult C57BL/6J mice.
Effect of a high-calorie diet and constant light exposure on female reproduction, metabolism and immune inflammation: A comparative study of different mouse models.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa.
Glucosephosphate Dehydrogenase Deficiency
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa.
glucuronosyltransferase deficiency
cDNA cloning and characterization of feline CYP1A1 and CYP1A2.
glutathione transferase deficiency
Environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women.
Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer.
Urinary 1-hydroxypyrene level relative to vehicle exhaust exposure mediated by metabolic enzyme polymorphisms.
Goiter, Nodular
Aberrant DNA methylation of drug metabolism and transport genes in nodular goiter.
[DIO2, TPO, CYP1A1 AND CYP1A2 gene polymorphism in women with thyroid disease].
Gonadal Dysgenesis
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Roles of forkhead box protein L2 (foxl2) during gonad differentiation and maintenance in a fish, the olive flounder (Paralichthys olivaceus).
Gout
Colchicine-antimicrobial drug interactions: what pharmacists need to know in treating gout.
Colchicine: serious interactions.
DFT and molecular docking investigations of oxicam derivatives.
Frequency of CYP2C9 polymorphisms in polynesian people and potential relevance to management of gout with benzbromarone.
Main contribution of UGT1A1 and CYP2C9 in the metabolism of UR-1102, a novel agent for the treatment of gout.
Mediation analysis to understand genetic relationships between habitual coffee intake and gout.
Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria Staphylococcus aureus and Pseudomonas aeruginosa.
[Association of single nucleotide polymorphisms of cytochrome P450 gene with susceptibility to gout in ethnic Han males from coastal regions of Shandong province].
Graft vs Host Disease
Cytochrome P450 1A2 is a target antigen in hepatitic graft-versus-host disease.
Impact of CYP3A5, POR, and CYP2C19 Polymorphisms on Trough Concentration to Dose Ratio of Tacrolimus in Allogeneic Hematopoietic Stem Cell Transplantation.
Granuloma
Alterations of hepatic microsomal enzymes in the early phase of murine schistosomiasis.
Granulosa Cell Tumor
Expression of P450 Aromatase in Granulosa Cell Tumors and Sertoli-Stromal Cell Tumors of the Ovary: Which Cells Are Responsible for Estrogenesis?
Immunohistochemical studies of steroidogenic enzymes (aromatase, 17 alpha-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary.
Immunolocalization of aromatase P-450 in ovarian tissue from pregnant and nonpregnant mares and in ovarian tumours.
Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads.
Graves Disease
Genetic polymorphisms associated with cigarette smoking and the risk of Graves' disease.
MATERNAL GRAVES DISEASE AND ABNORMAL CYP2D6 GENOTYPE WITH FETAL HYPERTHYROIDISM.
Gynecomastia
Association between gynecomastia and aromatase (CYP19) polymorphisms.
Dominant transmission of prepubertal gynecomastia due to serum estrone excess: hormonal, biochemical, and genetic analysis in a large kindred.
Genetic variants of estrogen beta and leptin receptors may cause gynecomastia in adolescent.
Multiple structural and functional abnormalities in the p450 aromatase expressing transgenic male mice are ameliorated by a p450 aromatase inhibitor.
Studies on the interactions between drug and estrogen. II. On the inhibitory effect of 29 drugs reported to induce gynecomastia on the oxidation of estradiol at C-2 or C-17.
Hallucinations
Venlafaxine-propafenone interaction resulting in hallucinations and psychomotor agitation.
[A case of olfactory hallucination with adult enuresis]
[Antituberculosis drugs toxicity in patients treated for latent tuberculosis infection.]
[Olfactive hallucinations and dreams]
Hamartoma
Aryl Hydrocarbon Receptor Activation in Acne Vulgaris Skin: A Case Series from the Region of Naples, Italy.
The cutaneous lesions of dioxin exposure: lessons from the poisoning of Victor Yushchenko.
Hand-Foot Syndrome
Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity.
[Validation of genetic polymorphisms associated to the toxicity of chemotherapy in colorectal cancer patients].
Head and Neck Neoplasms
Association and treatment response to capecitabine-based chemoradiotherapy with CYP2C9 polymorphism in head and neck cancer.
Association of CYP1A1 and CYP2D6 gene polymorphisms with head and neck cancer in Tunisian patients.
Association of cytochrome P450 1B1 haplotypes with head and neck cancer risk.
Association of polymorphism in cytochrome P450 2C9 with susceptibility to head and neck cancer and treatment outcome.
Association of poor metabolizers of cytochrome P450 2C19 with head and neck cancer and poor treatment response.
Combined effect of smoking and polymorphisms in tobacco carcinogen-metabolizing enzymes CYP1A1 and GSTM1 on the head and neck cancer risk in North Indians.
CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer.
Cytochrome P450 2E1 and head and neck cancer: Interaction with genetic and environmental risk factors.
Cytochrome P450 interactions in human cancers: new aspects considering CYP1B1.
Effects of cytochrome P450 1A1 and uridine-diphosphate-glucuronosyltransferase 1A1 allelic polymorphisms on the risk of development and the prognosis of head and neck cancers.
Expression of xenobiotic metabolizing genes in head and neck cancer tissues.
Functional CYP1A1 genetic variants, alone and in combination with smoking, contribute to development of head and neck cancers.
Genetic polymorphism of N-acetyltransferase-2, glutathione S-transferase-M1, and cytochromes P450IIE1 and P450IID6 in the susceptibility to head and neck cancer.
Genetic polymorphisms in head and neck cancer risk.
Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer.
Genetic variations and head and neck cancer risks.
Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions.
GSTM1, GSTT1, GSTP1, CYP1A1, and NAT1 polymorphisms, tobacco use, and the risk of head and neck cancer.
Hypermethylation of carcinogen metabolism genes, CYP1A1, CYP2A13 and GSTM1 genes in head and neck cancer.
Impact of CYP2D6 activity and cachexia progression on enantiomeric alteration of plasma tramadol and its demethylated metabolites and their relationships with central nervous system symptoms in head and neck cancer patients.
Improvement of cyclophosphamide activation by CYP2B6 mutants: from in silico to ex vivo.
Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India.
Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response.
Interactions Among Genetic Variants in Tobacco Metabolizing Genes and Smoking Are Associated with Head and Neck Cancer Susceptibility in North Indians.
Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer.
Meta-analyses of the effect of cytochrome P450 2E1 gene polymorphism on the risk of head and neck cancer.
Mutational analysis of xenobiotic metabolizing genes (CYP1A1 and GSTP1) in sporadic head and neck cancer patients.
Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome.
Polymorphism in cytochrome P4501A1 is significantly associated with head and neck cancer risk.
Polymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: susceptibility to head and neck cancers.
Re: Association of polymorphism in cytochrome P450 2C9 with susceptibility to head and neck cancer and treatment outcome: Pragmatic use of Hardy-Weinberg equilibrium and statistical interaction analysis.
Relevance of glutathione S-transferase M1 and cytochrome P450 1A1 genetic polymorphisms to the development of head and neck cancers.
Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.
The association of the CYP1A1 Ile462Val polymorphism with head and neck cancer risk: evidence based on a cumulative meta-analysis.
The cytochrome P450 2D6 (CYP2D6) gene polymorphism among breast and head and neck cancer patients.
The PstI/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: a meta-analysis based on 21 case-control studies.
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population.
[First results on the influence of polymorphisms at glutathione S-transferase, cytochrome P450, and tumor necrosis factor gene loci on the development of multiple head and neck cancer]
[Influence of glutathione s-transferase and cytochrome p450 polymorphisms on prognosis of head and neck cancer]
Head Injuries, Penetrating
[Disorders of olfactory function in penetrating head injuries sustained during war]
Healthcare-Associated Pneumonia
Functional polymorphisms in the CYP1A1, ACE, and IL-6 genes contribute to susceptibility to community-acquired and nosocomial pneumonia.
Genetic susceptibility to nosocomial pneumonia, acute respiratory distress syndrome and poor outcome in patients at risk of critical illness.
Hearing Loss
Acute and Chronic Molecular Signatures and Associated Symptoms of Blast Exposure in Military Breachers.
Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers.
Heart Arrest
Cardiac Arrest and Therapeutic Hypothermia Interaction with Isoform-specific Cytochrome P450 Drug Metabolism.
Dynamic determination of functional liver capacity with the LiMAx test in post-cardiac arrest patients undergoing targeted temperature management-A prospective trial.
Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response Following Cardiac Arrest: A Comprehensive Review of Preclinical and Clinical Investigations.
Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system.
Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.
Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model*
Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model.
Heart Block
Complete Heart Block Secondary to Flecainide Toxicity: Is It Time for CYP2D6 Genotype Testing?
First-Degree Atrioventricular Block with Tachycardia from Paliperidone and Mirtazapine Overdose.
Heart Defects, Congenital
Associations and interaction effects of maternal smoking and genetic polymorphisms of cytochrome P450 genes with risk of congenital heart disease in offspring: A case-control study.
Genetic and clinical determinants influencing warfarin dosing in children with heart disease.
Heart Diseases
Azole antimycotics and drug interactions in the perioperative period.
Evaluation of effects of polymorphism for metabolic enzymes on pharmacokinetics of carvedilol by population pharmacokinetic analysis.
Genetic and clinical determinants influencing warfarin dosing in children with heart disease.
Interactions Networks for Primary Heart Sarcomas.
Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W) dilated cardiomyopathy transgenic mice.
Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes.
Metoprolol oxidation polymorphism in Brazilian elderly cardiac patients.
Pharmacokinetics of dl-praeruptorin A after single-dose intravenous administration to rats with liver cirrhosis.
Polymorphisms in genes encoding acetylsalicylic acid metabolizing enzymes are unrelated to upper gastrointestinal health in cardiovascular patients on acetylsalicylic acid.
[Acquired long QT syndrome: a dominant problem?]
[Cardiac complications in patients with schizophrenic disorders]
Heart Failure
2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy.
Altered pharmacokinetics and excessive hypotensive effect of candesartan in a patient with the CYP2C91/3 genotype.
An investigation of CYP2D6 genotype and response to metoprolol CR/XL during dose titration in patients with heart failure: a MERIT-HF substudy.
Caffeine intake reduces incident atrial fibrillation at a population level.
Cilostazol: new drug. Intermittent claudication: too little efficacy, too many risks.
CYP2D6 Genetic Variation and Beta-Blocker Maintenance Dose in Patients with Heart Failure.
CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK?2 and enhancing nuclear translocation of Akt1.
Cytochrome P-450 and hepatic drug biotransformation during progressive cardiac disease in cardiomyopathic hamsters.
Cytochrome P450 2C9 is involved in flow-dependent vasodilation of peripheral conduit arteries in healthy subjects and in patients with chronic heart failure.
Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway.
Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol.
Effect of fluoxetine on carvedilol pharmacokinetics, CYP2D6 activity, and autonomic balance in heart failure patients.
Evaluation and Clinical Implication of Zhenwu Decoction on Seven Cytochrome P450 Enzyme in Chronic Heart Failure Rats.
Frequency of genetic polymorphism for adrenergic receptor beta and cytochrome p450 2D6 enzyme, and effects on tolerability of beta-blocker therapy in heart failure with reduced ejection fraction patients: The Beta GenTURK study.
Genetic Variation of Hepatic Enzymes Influence on ?-Blocker Dose in Patients With Reduced Ejection Fraction Heart Failure.
Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone.
Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients.
Increased risk of congestive heart failure in patients with acetaminophen poisoning: A nationwide cohort study.
Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W) dilated cardiomyopathy transgenic mice.
Modulation of cardiac and hepatic cytochrome P450 enzymes during heart failure.
Modulation of cardiac cytochrome P450 in patients with heart failure.
Molecular chaperone, HSP60, and cytochrome P450 2E1 co-expression in dilated cardiomyopathy.
Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1.
Pharmacogenetic-guided Warfarin Dosing Algorithm in African-Americans.
Pharmacogenomics of heart failure -- focus on drug disposition and action.
Polymorphisms in CYP2D6 may predict methamphetamine related heart failure.
Relation of ADRB1, CYP2D6, and UGT1A1 polymorphisms with dose of, and response to, carvedilol or metoprolol therapy in patients with chronic heart failure.
S-metoprolol: the 2008 clinical review.
Significance of L-carnitine in internal medicine.
Stereoselective metabolism of racemic carvedilol by UGT1A1 and UGT2B7, and effects of mutation of these enzymes on glucuronidation activity.
Sunitinib: new drug. For some gastrointestinal stromal tumours.
Variation in the CYP2D6 genotype is not associated with carvedilol dose changes in patients with heart failure.
[Polymorphisms of genesencoding enzymes of the xenobiotic detoxification system and the risk of infectious endocarditis].
Heart Failure, Diastolic
The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction.
Heart Failure, Systolic
An investigation of CYP2D6 genotype and response to metoprolol CR/XL during dose titration in patients with heart failure: a MERIT-HF substudy.
CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure.
Heart Valve Diseases
Prevalence of CYP2C9 and VKORC1 mutation in patients with valvular heart disease in northern Thailand.
Hemangioma
Effect of 22 Novel Cytochrome P450 2D6 (CYP2D6) Variants Found in the Chinese Population on Hemangeol Metabolism In Vitro.
Genotyping for CYP2D6 in Patients with Infantile Hemangiomas Refractory to Topical Timolol.
Influence of Cytochrome P450 2D6 Polymorphisms on the Efficacy of Oral Propranolol in Treating Infantile Hemangioma.
Hemangioma, Cavernous, Central Nervous System
Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.
Hematologic Neoplasms
Aberrant DNA methylation of key genes and Acute Lymphoblastic Leukemia.
Effect of CYP3A4, CYP3A5, and ABCB1 Polymorphisms on Intravenous Tacrolimus Exposure and Adverse Events in Adult Allogeneic Stem Cell Transplant Patients.
Identification of a new HLA-A*0201-restricted cryptic epitope from CYP1B1.
Pharmacogenetics of cyclophosphamide in patients with hematological malignancies.
Voriconazole and its clinical potential in the prophylaxis of systemic fungal infection in patients with hematologic malignancies: a perspective review.
Hematuria
CYP1A1 expression and organochlorine pesticides level in the etiology of bladder cancer in North Indian population.
Hemochromatosis
Effect of hemochromatosis on hepatic cytochrome P450 and antipyrine metabolism in humans.
Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans.
Role of iron in alcoholic liver disease: introduction and summary of the symposium.
Uroporphyria in the Cyp1a2-/- mouse.
[Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs].
Hemorrhagic Stroke
Metabolomic profiling of fatty acid biomarkers for intracerebral hemorrhage stroke.
Hepatic Encephalopathy
Influence of different substrates in detoxification activity of adult rat hepatocytes in long-term culture: implications for transplantation.
Hepatic Insufficiency
Albumin is a secret factor involved in multidirectional interactions among the serotoninergic, immune and endocrine systems that supervises the mechanism of CYP1A and CYP3A regulation in the liver.
Altered cytokine profile under control of the serotonergic system determines the regulation of CYP2C11 and CYP3A isoforms.
Olanzapine prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current.
S-metoprolol: the 2008 clinical review.
The impact of serotonergic system dysfunction on the regulation of P4501A isoforms during liver insufficiency and consequences for thyroid hormone homeostasis.
[Pharmacokinetics and pharmacodynamics: interactions and adverse effects. Comparison with other echinocandins]
Hepatitis
Anti-liver microsomes autoantibodies and dihydralazine-induced hepatitis: specificity of autoantibodies and inductive capacity of the drug.
Anti-LKM-1 antibodies determined by use of recombinant P450 2D6 in ELISA and western blot and their association with anti-HCV and HCV-RNA.
Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.
Antiretroviral therapy: are we aware of adverse effects?
Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2.
Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease.
Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists.
Chronic active hepatitis associated with vitiligo, nail dystrophy, alopecia and a new variant of LKM antibodies.
Correlation of induced drug metabolism with titer of duck hepatitis virus in chickens.
CYP2A5 Induction and Hepatocellular Stress: An Adaptive Response to Perturbations of Heme Homeostasis.
Cytochrome P450 2A6 is associated with macrophage polarization and is a potential biomarker for hepatocellular carcinoma.
Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection.
Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis.
Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications.
Cytochrome P450 enzymes and UDP-glucuronosyltransferases as hepatocellular autoantigens.
Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases.
Cytochromes P450 and UDP-glucuronosyl-transferases as hepatocellular autoantigens.
Cytochromes P450 and uridine triphosphate-glucuronosyltransferases: model autoantigens to study drug-induced, virus-induced, and autoimmune liver disease.
Dihydralazine-induced inactivation of cytochrome P450 enzymes in rat liver microsomes.
Distinct time courses of increase in cytochromes P450 1A2, 2A5 and glutathione S-transferases during the progressive hepatitis associated with Helicobacter hepaticus.
Drug metabolism in liver disease: activity of hepatic microsomal metabolizing enzymes.
Drug-induced liver injury associated with antiretroviral therapy that includes HIV-1 protease inhibitors.
Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.
Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons.
Expression of autoantibodies to specific cytochromes P450 in a case of disulfiram hepatitis.
Expression of Cytochrome P450 2A5 in a C57BL/6J Mouse Model of Nonalcoholic Fatty Liver Disease.
Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.
Expression of cytochrome P450 in LEC rats during the development of hereditary hepatitis and hepatoma.
Fatal hepatitis associated with isoflurane exposure and CYP2A6 autoantibodies.
Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients.
Hepatic cytochrome P450 and related drug biotransformation during an outbreak of mouse hepatitis virus in a colony of Swiss BALB/c mice.
Hepatoprotection by dimethyl sulfoxide. III. Role of inhibition of the bioactivation and covalent bonding of chloroform.
Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.
Identification of a 43-kDa protein in human liver cytosol that binds to the 3'-untranslated region of CYP2A6 mRNA.
Identification of a Shared Cytochrome p4502E1 Epitope Found in Anesthetic Drug-Induced and Viral Hepatitis.
Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis.
Immunotoxicology and expression of human cytochrome P450 in microorganisms.
Increased oxidative DNA damage and hepatocyte overexpression of specific cytochrome P450 isoforms in hepatitis of mice infected with Helicobacter hepaticus.
Individuals having variant genotypes of cytochrome P450 2C19 are at increased risk of developing primary liver cancer in Han populations, without infection with the hepatitis virus.
Interaction of heterogeneous nuclear ribonucleoprotein A1 with cytochrome P450 2A6 mRNA: implications for post-transcriptional regulation of the CYP2A6 gene.
Interactions of dihydralazine with cytochromes P4501A: a possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies.
Interferon therapy in LKM-1 positive patients with chronic hepatitis C: follow-up by a quantitative radioligand assay for CYP2D6 antibody detection.
Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis.
Is debrisoquine hydroxylation modified during acute viral hepatitis?
Lack of surface expression for the B-cell autoepitope of cytochrome P450 IID6 evidenced by flow cytometry.
Liver VDR, CYP2R1 and CYP27A1 expression: Relationship with liver histology and vitamin D3 levels in patients with NASH or HCV hepatitis.
LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase.
LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry?
Mechanism-based inactivation of cytochrome P450s 1A2 and 3A4 by dihydralazine in human liver microsomes.
Mice with liver composed of human hepatocytes as an animal model for drug testing.
Mild hepatitis at recommended doses of acetaminophen in patients with evidence of constitutionally enhanced cytochrome P450 system activity.
Minimal effect of cytokine-independent hepatitis induced by anti-Fas antibodies on hepatic cytochrome P450 gene expression in mice.
Opposite behaviors of reactive metabolites of tienilic acid and its isomer toward liver proteins: use of specific anti-tienilic acid-protein adduct antibodies and the possible relationship with different hepatotoxic effects of the two compounds.
Overexpression of cytochrome P-450 isoforms involved in aflatoxin B1 bioactivation in human liver with cirrhosis and hepatitis.
Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450 db1 that is inhibited by LKM-1 autoantibodies in vitro but not in vivo.
Polymorphisms in CYP2E1, GSTM1 and GSTT1 and anti-tuberculosis drug-induced hepatotoxicity.
Recurrent episodes of acute hepatitis associated with LKM-1 (cytochrome P450 2D6) antibodies in identical twin brothers.
Regulation of cytochrome P450 IID by acute phase mediators in C3H/HeJ mice.
Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis.
Role of CYP2E1 gene polymorphisms association with hepatitis risk in Northeast India.
Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets.
Suppression of cytochrome P450 gene expression in the livers of mice with concanavalin A-induced hepatitis.
Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury.
The topography of trifluoroacetylated protein antigens in liver microsomal fractions from halothane treated rats.
Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid.
Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.
Use of molecular simulation for mapping conformational CYP2E1 epitopes.
Vesicular transport of newly synthesized cytochromes P4501A to the outside of rat hepatocyte plasma membranes.
Voriconazole-Induced Hepatitis via Simvastatin- and Lansoprazole-Mediated Drug Interactions: A Case Report and Review of the Literature.
[HEV capsid protein interacts with CYP 2A6 and decreases its coumarin 7-hydroxylation activity]
[Monooxigenase activity in liver diseases (study based on data of antipyrine metabolism)]
[Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs].
Hepatitis A
Enzymes as target antigens of liver-specific autoimmunity: the case of cytochromes P450s.
Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions.
Hepatitis A impairs the function of human hepatic CYP2A6 in vivo.
Hepatitis B
Altered Levels of Cytochrome P450 Genes in Hepatitis B or C Virus-infected Liver Identified by Oligonucleotide Microarray.
Autologous NeoHep Derived from Chronic Hepatitis B Virus Patients' Blood Monocytes by Upregulation of c-MET Signaling.
Autologous NeoHep Derived From Chronic Hepatitis B Virus Patients' Blood Monocytes by Upregulation of cMET Signaling.
Comparison of Circulating, Hepatocyte Specific Messenger RNA and microRNA as Biomarkers for Chronic Hepatitis B and C.
Curative Effects of ZHENG-Based Fuzheng-Huayu Tablet on Hepatitis B Caused Cirrhosis Related to CYP1A2 Genetic Polymorphism.
Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to hepatitis B virus and aflatoxin B1-and 4-aminobiphenyl-DNA adducts.
Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: Association with hepatitis B related advanced liver disease and cancer.
Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis.
Liver cancer-related gene CYP2E1 expression in HBV transgenic mice with acute liver injury.
Microsomal function in hepatitis B surface antigen healthy carriers: assessment of cytochrome P450 1A2 activity by the 14C-caffeine breath test.
Overexpression of cytochrome P-450 isoforms involved in aflatoxin B1 bioactivation in human liver with cirrhosis and hepatitis.
The question of ethnic variability and the Darwinian significance of physiological neonatal jaundice in East Asian populations.
Hepatitis B, Chronic
Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection.
Comparison of Circulating, Hepatocyte Specific Messenger RNA and microRNA as Biomarkers for Chronic Hepatitis B and C.
Curative Effects of ZHENG-Based Fuzheng-Huayu Tablet on Hepatitis B Caused Cirrhosis Related to CYP1A2 Genetic Polymorphism.
Cytochrome P450 1A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers.
Cytochrome P450 Genes (CYP2E1 and CYP1A1) Variants and Susceptibility to Chronic Hepatitis B Virus Infection.
HBx inhibits CYP2E1 gene expression via downregulating HNF4? in human hepatoma cells.
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Immunoreactivity to various human cytochrome P450 proteins of sera from patients with autoimmune hepatitis, chronic hepatitis B, and chronic hepatitis C.
[Relationship between the genetic polymorphism of CYP3A5 gene and the clinical response to Bicyclol in chronic hepatitis B]
Hepatitis C
ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients.
Association of CYP2B6 Single-Nucleotide Polymorphisms Altering Efavirenz Metabolism With Hepatitis C Virus (HCV) Treatment Relapse Among Human Immunodeficiency Virus/HCV-Coinfected African Americans Receiving Ledipasvir/Sofosbuvir in the ION-4 Trial.
Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors.
Clinical and genetic determinants of nevirapine plasma trough concentration.
Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation.
Clinical treatment for hepatitis C reverses CYP2C19 inhibition.
Comparison of Circulating, Hepatocyte Specific Messenger RNA and microRNA as Biomarkers for Chronic Hepatitis B and C.
CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer.
CYP24A1 genetic variants in the vitamin D metabolic pathway are involved in the outcomes of hepatitis C virus infection among high-risk Chinese population.
Development of cytochrome P450 2D6-specific LKM-autoantibodies following liver transplantation for Wilson's disease -- possible association with a steroid-resistant transplant rejection episode.
Differences in anti-LKM-1 autoantibody immunoreactivity to CYP2D6 antigenic sites between hepatitis C virus-negative and -positive patients.
Distribution of Polymorphisms in Cytochrome P450 2B6, Histocompatibility Complex P5, Chemokine Coreceptor 5, and Interleukin 28B Genes in Inhabitants from the Central Area of Argentina.
Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.
Effect of interferon alpha-ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N-acetyltransferase-2 activities in patients with chronic active hepatitis C.
Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus.
Enhanced bioactivity of silybin B methylation products.
Epitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during alpha-interferon treatment.
Ethanol and hepatocellular injury.
Genetic polymorphisms of cytochrome P450 in patients with hepatitis C virus-associated hepatocellular carcinoma.
Genetic polymorphisms of enzymes related to oral tegafur/uracil therapeutic efficacy in patients with hepatocellular carcinoma.
Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.
Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1.
Hepatotropic viruses and autoimmunity 1997.
Impact of CYP2R1, CYP27A1 and CYP27B1 genetic polymorphisms controlling vitamin D metabolism on susceptibility to hepatitis C virus infection in a high-risk Chinese population.
Impact of low-dose ritonavir on danoprevir pharmacokinetics: results of computer-based simulations and a clinical drug-drug interaction study.
Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1.
Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: In vitro and in vivo correlation.
Interferon therapy in LKM-1 positive patients with chronic hepatitis C: follow-up by a quantitative radioligand assay for CYP2D6 antibody detection.
LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry?
Minor contribution of CYP3A5 to the metabolism of hepatitis C protease inhibitor paritaprevir in vitro.
Molecular mimicry of human cytochrome P450 by hepatitis C virus at the level of cytotoxic T cell recognition.
Overexpression of cytochrome P-450 isoforms involved in aflatoxin B1 bioactivation in human liver with cirrhosis and hepatitis.
Overlapping but distinct specificities of anti-liver-kidney microsome antibodies in autoimmune hepatitis type II and hepatitis C revealed by recombinant native CYP2D6 and novel peptide epitopes.
Patterns of expression of cytochrome P450 genes in progression of hepatitis C virus-associated hepatocellular carcinoma.
Porphyria cutanea tarda.
Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis C virus replicon-expressing cells.
Ribavirin pharmacokinetics and interleukin 28B plus cytochrome P450 27B1 single-nucleotide polymorphisms as predictors of response to pegylated interferon/ribavirin treatment in patients infected with hepatitis C virus genotype 1/4.
Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.
Sera of children with hepatitis C infection and anti-liver-kidney microsome-1 antibodies recognize different CYP2D6 epitopes than adults with LKM+/HCV+ sera.
Serum autoantibodies against cytochrome P450 2E1 (CYP2E1) predict severity of necroinflammation of recurrent hepatitis C.
Successful telaprevir treatment in combination of cyclosporine against recurrence of hepatitis C in the Japanese liver transplant patients.
The aryl hydrocarbon receptor-cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly.
The interactions of age, sex, body mass index, genetics, and steroid weight-based doses on tacrolimus dosing requirement after adult kidney transplantation.
Two-way interaction study between ritonavirboosted danoprevir, a potent HCV protease inhibitor, and ketoconazole in healthy subjects.
Viral induction of autoimmunity: mechanisms and examples in hepatology.
[Pharmacokinetic interactions of telaprevir with other drugs].
Hepatitis C, Chronic
A major CYP2D6 autoepitope in autoimmune hepatitis type 2 and chronic hepatitis C is a three-dimensional structure homologous to other cytochrome P450 autoantigens.
A new approach to cytochrome CYP2D6 antibody detection in autoimmune hepatitis type-2 (AIH-2) and chronic hepatitis C virus (HCV) infection: a sensitive and quantitative radioligand assay.
A randomised study of the effect of danoprevir/ritonavir or ritonavir on substrates of cytochrome P450 (CYP) 3A and 2C9 in chronic hepatitis C patients using a drug cocktail.
Autoimmune liver disease.
Comparison of cytochrome P4502E1 (CYP2E1) activity and hepatic and lymphocyte mRNA expression in patients with chronic hepatitis C.
CYP2D6 polymorphism and the presence of anti-LKM-1 in patients with chronic hepatitis C.
Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection.
Cytochrome P4502E1 (CYP2E1) expression in peripheral blood lymphocytes: evaluation in hepatitis C and diabetes.
Cytochromes P450 and UDP-glucuronosyl-transferases as hepatocellular autoantigens.
Cytochromes P450 and uridine triphosphate-glucuronosyltransferases: model autoantigens to study drug-induced, virus-induced, and autoimmune liver disease.
Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients.
Differences in antigenic sites, recognized by anti-liver-kidney microsome-1 (LKM-1) autoantibody, between HCV-positive and HCV-negative sera in Japanese patients.
Dose reduction effective in alleviating symptoms of saquinavir toxicity.
Drug-drug interactions in the treatment of HCV among people who inject drugs.
Effect of interferon alpha-ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N-acetyltransferase-2 activities in patients with chronic active hepatitis C.
Effect of nuclear receptor downregulation on hepatic expression of cytochrome P450 and transporters in chronic hepatitis C in association with fibrosis development.
Effect of telaprevir on the metabolism and hepatic uptake of tacrolimus (FK506).
Effects of multiple-dose pegylated interferon alfa-2b on the activity of drug-metabolizing enzymes in persons with chronic hepatitis C.
Genetic Polymorphisms of Cytochrome P4501A1 (CYP1A1) and Glutathione S-Transferase P1 (GSTP1) and Risk of Hepatocellular Carcinoma Among Chronic Hepatitis C Patients in Egypt.
Immunoreactivity to various human cytochrome P450 proteins of sera from patients with autoimmune hepatitis, chronic hepatitis B, and chronic hepatitis C.
Influence of chronic hepatitis C infection on cytochrome P450 3a4 activity using midazolam as an in vivo probe substrate.
Interferon therapy in LKM-1 positive patients with chronic hepatitis C: follow-up by a quantitative radioligand assay for CYP2D6 antibody detection.
Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule.
Liver function parameters in HIV/HCV co-infected patients treated with amprenavir and ritonavir and correlation with plasma levels.
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection.
Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir: A Review in Chronic HCV Genotype 1 Infection.
Role of CYP2D6 polymorphism in predicting liver fibrosis progression rate in Caucasian patients with chronic hepatitis C.
Steatosis in chronic hepatitis C: association with increased messenger RNA expression of collagen I, tumor necrosis factor-alpha and cytochrome P450 2E1.
Viral induction of autoimmunity: mechanisms and examples in hepatology.
Vitamin D pathway gene variants and HCV-2/3 therapy outcomes.
[CLINICAL AND ENDOSCOPIC CHARACTERISTICS OF THE GASTRODUODENAL MUCOSAL LESIONS IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION WITH DIFFERENT BODY MASS STATUS].
Hepatitis D
Viral induction of autoimmunity: mechanisms and examples in hepatology.
Hepatitis, Alcoholic
A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease.
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice.
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis.
[Genetic susceptibility to the development of acute alcoholic hepatitis: role of genetic mutations in dehydrogenase alcohol, aldehyde dehydrogenase and cytochrome P450 2E1]
Hepatitis, Autoimmune
A major CYP2D6 autoepitope in autoimmune hepatitis type 2 and chronic hepatitis C is a three-dimensional structure homologous to other cytochrome P450 autoantigens.
A new approach to cytochrome CYP2D6 antibody detection in autoimmune hepatitis type-2 (AIH-2) and chronic hepatitis C virus (HCV) infection: a sensitive and quantitative radioligand assay.
A new epitope of CYP2D6 recognized by liver kidney microsomal autoantibody from japanese patients with autoimmune hepatitis.
Anti-liver-kidney microsome antibody type 1 recognizes human cytochrome P450 db1.
Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2.
Autoantibodies associated with acute rejection after liver transplantation for type-2 autoimmune hepatitis.
Autoantibody detection in type 2 autoimmune hepatitis using a chimera recombinant protein.
Autoimmune liver disease.
Cytochrome P450 2D6 as a model antigen.
Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes.
Cytochromes P450 and UDP-glucuronosyl-transferases as hepatocellular autoantigens.
Detection of anti-LKM-1(anti-CYP2D6) by an enzyme-linked immunosorbent assay in adult patients with chronic liver diseases.
Detection on immunoblot of new proteins from the microsomal fraction recognized by anti-liver-kidney microsome antibodies type 1.
Development of cytochrome P450 2D6-specific LKM-autoantibodies following liver transplantation for Wilson's disease -- possible association with a steroid-resistant transplant rejection episode.
Differences in anti-LKM-1 autoantibody immunoreactivity to CYP2D6 antigenic sites between hepatitis C virus-negative and -positive patients.
Differences in antigenic sites, recognized by anti-liver-kidney microsome-1 (LKM-1) autoantibody, between HCV-positive and HCV-negative sera in Japanese patients.
Enzymes as target antigens of liver-specific autoimmunity: the case of cytochromes P450s.
Epitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during alpha-interferon treatment.
Epitope mapping of human CYP1A2 in dihydralazine-induced autoimmune hepatitis.
Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model.
Frequency and significance of anti-glutathione S-transferase autoantibody (anti-GST A1-1) in autoimmune hepatitis.
Hepatitis C infection and autoimmunity.
Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease.
Identification of the main epitope on human cytochrome P450 IID6 recognized by anti-liver kidney microsome antibody.
Immunoreactivity to various human cytochrome P450 proteins of sera from patients with autoimmune hepatitis, chronic hepatitis B, and chronic hepatitis C.
Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule.
LKM-1 sera from autoimmune hepatitis patients that recognize ERp57, carboxylesterase 1 and CYP2D6.
LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry?
Molecular mimicry of human cytochrome P450 by hepatitis C virus at the level of cytotoxic T cell recognition.
Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis.
Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model.
Organ-specific and non-organ-specific autoantibodies in children and young adults with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Overlapping but distinct specificities of anti-liver-kidney microsome antibodies in autoimmune hepatitis type II and hepatitis C revealed by recombinant native CYP2D6 and novel peptide epitopes.
Study of CYP2D6 gene in children with autoimmune hepatitis and P450 IID6 autoantibodies.
Susceptibility to thyroid disorders in hepatitis C.
Target proteins in human autoimmunity: cytochromes P450 and UDP- glucuronosyltransferases.
Terbinafine-induced acute autoimmune hepatitis in the setting of hepatitis B virus infection.
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice.
Transitioning from Idiopathic to Explainable Autoimmune Hepatitis.
Viral triggers for autoimmunity: Is the 'glass of molecular mimicry' half full or half empty?
[Establishment of a mouse model of autoimmune hepatitis induced by human CYP2D6].
Hepatitis, Chronic
Anti-LKM-1 antibodies determined by use of recombinant P450 2D6 in ELISA and western blot and their association with anti-HCV and HCV-RNA.
Chronic active hepatitis associated with vitiligo, nail dystrophy, alopecia and a new variant of LKM antibodies.
Effect of interferon alpha-ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N-acetyltransferase-2 activities in patients with chronic active hepatitis C.
Human cytochrome P4501A2.
In vivo metabolic activity of CYP2C19 and CYP3A in relation to CYP2C19 genetic polymorphism in chronic liver disease.
Lack of surface expression for the B-cell autoepitope of cytochrome P450 IID6 evidenced by flow cytometry.
LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase.
Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450 db1 that is inhibited by LKM-1 autoantibodies in vitro but not in vivo.
Pharmacokinetics of oltipraz in diabetic rats with liver cirrhosis.
Regulation of cytochrome P450 IID by acute phase mediators in C3H/HeJ mice.
Hepatoblastoma
Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells.
Cell-specific regulation of human CYP1A1 and CYP1B1 genes.
Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells.
CYP2E1-mediated modulation of valproic acid-induced hepatocytotoxicity.
Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7.
Differential expression of glutamine synthetase and cytochrome P450 isoforms in human hepatoblastoma.
HepG2-1A2 C2 and C7: Lentivirus vector-mediated stable and functional overexpression of cytochrome P450 1A2 in human hepatoblastoma cells.
Inducing effects of dioxin-like polychlorinated biphenyls on CYP1A in the human hepatoblastoma cell line HepG2, the rat hepatoma cell line H4IIE, and rat primary hepatocytes: comparison of relative potencies.
Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4.
Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells.
Optimization of Albumin Secretion and Metabolic Activity of Cytochrome P450 1A1 of Human Hepatoblastoma HepG2 Cells in Multicellular Spheroids by Controlling Spheroid Size.
Role of nitroreductases but not cytochromes P450 in the metabolic activation of 1-nitropyrene in the HepG2 human hepatoblastoma cell line.
Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen.
Structure-dependent genotoxic potencies of selected pyrrolizidine alkaloids in metabolically competent HepG2 cells.
Transcriptional control of human cytochrome P1-450 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human tissue culture cell lines.
Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.
Hepatolenticular Degeneration
Development of cytochrome P450 2D6-specific LKM-autoantibodies following liver transplantation for Wilson's disease -- possible association with a steroid-resistant transplant rejection episode.
Hepatic drug-metabolizing enzymes and drug transporters in Wilson's disease patients with liver failure.
Hepatomegaly
Aspects of dioxin toxicity are mediated by interleukin 1-like cytokines.
Biochemical and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in immature male and female chickens.
CYP1A2 is not required for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunosuppression.
Early hepatic changes induced in rats by two hepatocarcinogenic organohalogen pesticides: bromopropylate and DDT.
Experimental studies on pharmacology, metabolism and toxicology with tiadenol-disulfoxide. Dissociation of lipid lowering effects and the induction of peroxisomal and microsomal drug-metabolizing enzymes.
Fenofibrate, a ligand for PPARalpha, inhibits aromatase cytochrome P450 expression in the ovary of mouse.
Interactive effects of methyl tertiary-butyl ether (MTBE) and tertiary-amyl methyl ether (TAME), ethanol and some drugs: Triglyceridemia, liver toxicity and induction of CYP (2E1, 2B1) and phase II enzymes in female Wistar rats.
Loss of tumor-promoting activity of unleaded gasoline in N-nitrosodiethylamine-initiated ovariectomized B6C3F1 mouse liver.
Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1.
Time and dose-dependent effects of phenobarbital on the rat liver miRNAome.
Toxicological approach for elucidation of clobazam-induced hepatomegaly in male rats.
Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.
[Changes in the hydroxylating function and structure of the hepatic endoplasmic reticulum of the rat as affected by long-term kordiamin administration]
Hepatorenal Syndrome
Cytochrome P450 metabolites of arachidonic acid in the control of renal function.
Herpes Simplex
Differential cytotoxicity and bystander effect of the rabbit cytochrome P450 4B1 enzyme gene by two different prodrugs: implications for pharmacogene therapy.
Enhanced green fluorescent protein fusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome P450 4B1: applications for prodrug-activating gene therapy.
Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.
Identification of the main epitope on human cytochrome P450 IID6 recognized by anti-liver kidney microsome antibody.
Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies.
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
Response of the ileum transcriptome to fructo-oligosaccharides in Taiping chickens.
Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity.
Herpes Zoster
A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase and cytochrome b5 compete for the same binding site on cytochrome P450c17.
A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: histochemical detection and possible physiological role.
Adrenal activation of carbon tetrachloride: role of microsomal P450 isozymes.
Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors.
Calcium regulates human CYP11B2 transcription.
Calf adrenocortical fasciculata cells secrete aldosterone when placed in primary culture.
Cellular and Molecular Impact of Vitrification Versus Slow Freezing on Ovarian Tissue.
Cloning and expression of a rat cytochrome P-450 11 beta-hydroxylase/aldosterone synthase (CYP11B2) cDNA variant.
Cloning and expression of the rat adrenal cytochrome P-450 11B3 (CYP11B3) enzyme cDNA: preferential 18-hydroxylation over 11 beta-hydroxylation of DOC.
Colocalization of P450 Aromatase and Oxytocin Immunostaining in the Rat Hypothalamus.
Congenital hypoaldosteronism: the Visser-Cost syndrome revisited.
Development of adrenal zonation in fetal rats defined by expression of aldosterone synthase and 11beta-hydroxylase.
Differential effects of adrenocorticotropin in vivo on cytochromes P4502D16 and P450c17 in the guinea pig adrenal cortex.
Effects of age and adrenocorticotropin on microsomal enzymes in guinea pig adrenal inner and outer cortices.
Effects of cyclopenta[c]phenanthrene and its derivatives on zona radiata protein, ERalpha, and CYP1A mRNA expression in liver of rainbow trout (Oncorhynchus mykiss Walbaum).
Effects of dietary soy and estrous cycle on adrenal cytochrome p450 1B1 expression and DMBA metabolism in adrenal glands and livers in female Sprague-Dawley rats.
Effects of long term stimulation of ACTH and angiotensin II-secretions on the rat adrenal cortex.
Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria.
Endocrine Disruptors in Mediterranean top marine predators.
Estrogenic effects of selected hydroxy polychlorinated biphenyl congeners in primary culture of Atlantic Salmon (Salmo salar) hepatocytes.
Evaluation of ecotoxicological effects of endocrine disrupters during a four-year survey of the Mediterranean population of swordfish (Xiphias gladius).
Gender and gonadal status differences in zona reticularis expression in marmoset monkey adrenals: Cytochrome b5 localization with respect to cytochrome P450 17,20-lyase activity.
Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.
Immunocytochemical analyses of dehydroepiandrosterone sulfotransferase in cultured human fetal adrenal cells.
Immunohistochemical localization of CYP1A, vitellogenin and Zona radiata proteins in the liver of swordfish (Xiphias gladius L.) taken from the Mediterranean Sea, South Atlantic, South Western Indian and Central North Pacific Oceans.
Induction of steroidogenic enzymes by potassium in cultured rat zona glomerulosa cells depends on calcium influx and intact protein synthesis.
Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes.
Maturational changes in CYP2D16 expression and xenobiotic metabolism in adrenal glands from male and female guinea pigs.
Mitochondrial redox components of human adrenocortical steroid hydroxylases under physiological conditions and in focal hyperplasia of the zone fasciculata.
Molecular Analysis of Endocrine Disruption in Hornyhead Turbot at Wastewater Outfalls in Southern California Using a Second Generation Multi-Species Microarray.
Multisteroid analysis in children with terminal aldosterone biosynthesis defects.
Potential toxicological hazard due to endocrine-disrupting chemicals on Mediterranean top predators: state of art, gender differences and methodological tools.
Regulation of aldosterone synthase cytochrome P450 (CYP11B2) and 11 beta-hydroxylase cytochrome P450 (CYP11B1) expression in rat adrenal zona glomerulosa cells by low sodium diet and angiotensin II receptor antagonists.
Risk of herpes zoster in patients prescribed inhaled corticosteroids: a cohort study.
Sympathoadrenal regulation of adrenal androstenedione release.
Target cells for cytochrome p450-catalysed irreversible binding of 7,12-dimethylbenz[a]anthracene (DMBA) in rodent adrenal glands.
Targeted salmon gene array (SalArray): a toxicogenomic tool for gene expression profiling of interactions between estrogen and aryl hydrocarbon receptor signalling pathways.
The expression of CYP1A, vitellogenin and zona radiata proteins in Atlantic salmon (Salmo salar) after oral dosing with two commercial PBDE flame retardant mixtures: absence of short-term responses.
The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation.
Transcriptional response of honey bee larvae infected with the bacterial pathogen Paenibacillus larvae.
Upadacitinib tartrate in rheumatoid arthritis.
Zonal expression of endothelial nitric oxide synthase in sheep and rhesus adrenal cortex.
Hirschsprung Disease
Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population.
Hirsutism
P450 inhibitors of use in medical treatment: focus on mechanisms of action.
Histiocytoma
An Excess of CYP24A1, Lack of CaSR, and a Novel lncRNA Near the PTH Gene Characterize an Ectopic PTH-Producing Tumor.
HIV Infections
CYP1A1 and 1B1-mediated metabolic pathways of dolutegravir, an HIV integrase inhibitor.
CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection.
Effect of CYP2B6 Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection.
Effect of Seville orange juice and grapefruit juice on indinavir pharmacokinetics.
Effect of zidovudine therapy in patients with HIV infection on endogenous interferon plasma levels and the hepatic cytochrome P450 enzyme system.
Exploring CYP2B6 activity by measuring the presence ofnevirapine hydroxy metabolites in plasma.
Pharmacokinetics and Placental Transfer of Bupivacaine Enantiomers in HIV-Infected Parturient Women on Antiretroviral Therapy.
Pilot study evaluating the interaction between paclitaxel and protease inhibitors in patients with human immunodeficiency virus-associated Kaposi's sarcoma: an Eastern Cooperative Oncology Group (ECOG) and AIDS Malignancy Consortium (AMC) trial.
Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir.
Treatment of chronic HCV genotype 1 coinfection.
Tribal ethnicity and CYP2B6 genetics in Ugandan and Zimbabwean populations in the UK: implications for efavirenz dosing in HIV infection.
Hodgkin Disease
Drug interactions between antineoplastic and antiretroviral therapies: Implications and management for clinical practice.
WebHERV: A Web Server for the Computational Investigation of Gene Expression Associated With Endogenous Retrovirus-Like Sequences.
Holoprosencephaly
Ethanol itself is a holoprosencephaly-inducing teratogen.
Hookworm Infections
Hepatic microsomal cytochrome P450 system during experimental hookworm infection.
Huntington Disease
Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high-altitude adaptation.
Hydatidiform Mole
Quantitative evaluation of human placental aromatase in abnormal pregnancy--anencephalus and hydatidiform mole.
Hydronephrosis
Localization of cytochrome P450 1A1 in a specific region of hydronephrotic kidney of rat neonates lactationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Hydrophthalmos
Axenfeld-Rieger Syndrome Associated with Congenital Glaucoma and Cytochrome P4501B1 Gene Mutations.
Sturge-Weber Syndrome With Congenital Glaucoma and Cytochrome P450 (CYP1B1) Gene Mutations.
Hyperaldosteronism
Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria.
Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin.
Hyperalgesia
3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.
The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain.
Hyperandrogenism
Association between CYP19 gene SNP rs2414096 polymorphism and polycystic ovary syndrome in Chinese women.
Current developments in the molecular genetics of the polycystic ovary syndrome.
Effects of testosterone on PPAR? and P450arom expression in polycystic ovary syndrome patients and related mechanisms.
Impact of rs2414096 polymorphism of CYP19 gene on susceptibility of polycystic ovary syndrome and hyperandrogenism in Kashmiri women.
Impaired gonadal function in a woman with multiple symmetric lipomatosis.
Pathogenesis of polycystic ovary syndrome: evidence for a genetically determined disorder of ovarian androgen production.
Polycystic ovary syndrome: evidence for a primary disorder of ovarian steroidogenesis.
Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS.
SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients.
Transcutaneous electrical acupoint stimulation alleviates the hyperandrogenism of polycystic ovarian syndrome rats by regulating the expression of P450arom and CTGF in the ovaries.
[Effect of anti-Müllerian hormone on P450 aromatase mRNA expression in cultured human luteinized granulose cells]
Hypercalcemia
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D.
25-Hydroxyvitamin D3 24-Hydroxylase: A Key Regulator of 1,25(OH)2D3 Catabolism and Calcium Homeostasis.
A Case of "Late Onset" Idiopathic Infantile Hypercalcemia Secondary to Mutations in The CYP24A1 Gene.
A case report of severe vitamin D intoxication
A lifetime of hypercalcemia and hypercalciuria, finally explained.
A Model of Calcium Homeostasis in the Rat.
A novel CYP24A1 genotype associated to a clinical picture of hypercalcemia, nephrolithiasis and low bone mass.
A rapid screening of a recurrent CYP24A1 pathogenic variant opens the way to molecular testing for Idiopathic Infantile Hypercalcemia (IIH).
A Young Woman with Recurrent Gestational Hypercalcemia and Acute Pancreatitis Due to CYP24A1 Deficiency.
Analysis of vitamin D3 metabolites in survivors of infantile idiopathic hypercalcemia caused by CYP24A1 mutation or SLC34A1 mutation.
Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia.
Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: molecular study of 11 historical IIH cases.
Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D3 and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D3.
Calcium and bone homeostasis in heterozygous carriers of CYP24A1 mutations: A cross-sectional study.
Calcium pyrophosphate deposition disease revealing a hypersensitivity to vitamin D.
Clinical and biochemical phenotypes of adults with monoallelic and biallelic CYP24A1 mutations: evidence of gene dose effect.
CYP24A1 and SLC34A1 genetic defects associated with idiopathic infantile hypercalcemia: from genotype to phenotype.
CYP24A1 and SLC34A1 Pathogenic Variants Are Uncommon in a Canadian Cohort of Children with Hypercalcemia or Hypercalciuria.
CYP24A1 inhibition enhances the antitumor activity of calcitriol.
CYP24A1 loss of function: Clinical phenotype of monoallelic and biallelic mutations.
CYP24A1 Mutations in a Cohort of Hypercalcemic Patients: Evidence for a Recessive Trait.
CYP24A1 mutations in idiopathic infantile hypercalcemia.
CYP24A1 Variants in Two Chinese Patients with Idiopathic Infantile Hypercalcemia.
CYP3A4 induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients with CYP24A1 Mutations.
Differential diagnosis of vitamin D-related hypercalcemia using serum vitamin D metabolite profiling.
Discordant Clinical Course of Vitamin-D-Hydroxylase (CYP24A1) Associated Hypercalcemia in Two Adult Brothers With Nephrocalcinosis.
Do the Heterozygous Carriers of a CYP24A1 Mutation Display a Different Biochemical Phenotype Than Wild Types?
Duplex high resolution melting analysis (dHRMA) to detect two hot spot CYP24A1 pathogenic variants (PVs) associated to idiopathic infantile hypercalcemia (IIH).
Erratum to: A novel CYP24A1 genotype associated to a clinical picture of hypercalcemia, nephrolithiasis and low bone mass.
External Quality Assessment of 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) assays.
Family History is Important to Identify Patients with Monogenic Causes of Adult-Onset Chronic Kidney Disease.
Genetic defect in CYP24A1, the vitamin D 24-hydroxylase gene, in a patient with severe infantile hypercalcemia.
Genetic disorders of Vitamin D biosynthesis and degradation.
Girl with idiopathic childhood hypercalcemia reveals new disease-causing CYP24A1 mutation.
Hereditary Hypercalcemia Caused by a Homozygous Pathogenic Variant in the CYP24A1 Gene: A Case Report and Review of the Literature.
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
Hypercalcemia due to all trans retinoic acid in the treatment of acute promyelocytic leukemia potentiated by voriconazole.
Hypercalcemia, Hypercalciuria, and Elevated Calcitriol Concentrations with Autosomal Dominant Transmission Due to CYP24A1 Mutations: Effects of Ketoconazole Therapy.
Hypercalcemia. Pathophysiological aspects.
Hyperparathyroidism complicating CYP 24A1 mutations.
Iatrogenic vitamin D toxicity in an infant - a case report and review of literature.
Idiopathic infantile hypercalcemia: mutations in SLC34A1 and CYP24A1 in two siblings and fathers.
Improved Screening Test for Idiopathic Infantile Hypercalcemia Confirms Residual Levels of Serum 24,25-(OH)
Infantile hypercalcemia with novel compound heterozygous mutation in SLC34A1 encoding renal sodium-phosphate cotransporter 2a: a case report.
Intravenous pamidronate in the treatment of severe idiopathic infantile hypercalcemia.
Kidney function and influence of sunlight exposure in patients with impaired 24-hydroxylation of vitamin D due to CYP24A1 mutations.
LC-MS/MS for Identifying Patients with CYP24A1 Mutations.
Lightwood Syndrome Revisited with a Novel Mutation in CYP24 and Vitamin D Supplement Recommendations.
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Maternal and infantile hypercalcemia caused by vitamin-D-hydroxylase mutations and vitamin D intake.
Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations.
Molecular characterization of a recurrent 10.9?kb CYP24A1 deletion in Idiopathic Infantile Hypercalcemia.
Mutational Spectrum of CYP24A1 Gene in a Cohort of Italian Patients with Idiopathic Infantile Hypercalcemia.
Mutations in CYP24A1 and idiopathic infantile hypercalcemia.
Novel CYP24A1 Mutation in a Young Male Patient with Nephrolithiasis: Case Report.
Promise of vitamin D analogues in the treatment of hyperproliferative conditions.
Quantitation of CYP24A1 Enzymatic Activity With a Simple Two-Hybrid System.
Re: A Rapid Screening of a Recurrent CYP24A1 Pathogenic Variant Opens the Way to Molecular Testing for Idiopathic Infantile Hypercalcemia (IIH).
Severe hypercalcemic crisis in an infant with idiopathic infantile hypercalcemia caused by mutation in CYP24A1 gene.
Sources of variation evaluation of 24,25(OH)2D levels and the ratio of 25OHD to 24,25(OH)2D in apparently healthy Chinese adults: a multicenter cross-sectional study.
Targeted delivery of 1,25-dihydroxyvitamin D3 to colon tissue and identification of a major 1,25-dihydroxyvitamin D3 glycoside from Solanumglaucophyllum plant leaves.
Therapy-Resistant Hypercalcemia in a Patient with Inactivating CYP24A1 Mutation and Recurrent Nephrolithiasis: Beware of Concomitant Hyperparathyroidism.
Three Sisters With Heterozygous Gene Variants of CYP24A1: Maternal Hypercalcemia, New-Onset Hypertension, and Neonatal Hypoglycemia.
Ultra-rare renal diseases diagnosed with whole-exome sequencing: Utility in diagnosis and management.
Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG.
VITAMIN D-MEDIATED HYPERCALCEMIA: MECHANISMS, DIAGNOSIS AND TREATMENT.
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
When a maternal heterozygous mutation of the CYP24A1 gene leads to infantile hypercalcemia through a maternal uniparental disomy of chromosome 20.
[Molecular and genetic technologies for the diagnosis of monogenic forms of urinary stone disease: clinical cases].
Hypercholesterolemia
Association of polymorphism in the cytochrome CYP2D6 and the efficacy and tolerability of simvastatin.
Construction of a novel expression vector in Pseudonocardia autotrophica and its application to efficient biotransformation of compactin to pravastatin, a specific HMG-CoA reductase inhibitor.
Contribution of arachidonic acid metabolites to reduced norepinephrine-induced contractions in hypercholesterolemic rabbit aortas.
CYP3A53A allele is associated with reduced lowering-lipid response to atorvastatin in individuals with hypercholesterolemia.
Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice.
Differential expression of hepatic genes involved in cholesterol homeostasis in high- and low-responding strains of laboratory opossums.
Enhancement of hepatic drug biotransformation rate by polychlorinated biphenyls in rats fed cholesterol-rich diet.
GENERATION OF HUMAN CHIRAL METABOLITES OF SIMVASTATIN AND LOVASTATIN BY BACTERIAL CYP102A1 MUTANTS.
Impact of CYP3A5 Gene Polymorphism on Efficacy of Simvastatin.
Importance of endothelium-derived hyperpolarizing factor in human arteries.
Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient mice.
Overexpression of cholesterol 7?-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis.
Polysaccharide from fuzi (FPS) prevents hypercholesterolemia in rats.
Proteomic analysis for the impact of hypercholesterolemia on expressions of hepatic drug transporters and metabolizing enzymes.
Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin.
Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid.
Unusual genetic variants associated with hypercholesterolemia in Argentina.
Hyperemia
Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats.
Metabolic control of muscle blood flow during exercise in humans.
Hyperglycemia
Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis.
Cytochrome P450 2E1 and hyperglycemia-induced liver injury.
Differential regulation of hepatic cytochrome P450 monooxygenases in streptozotocin-induced diabetic rats.
Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population.
Effect of insulin-mimetic vanadyl sulfate on cytochrome P450 2E1-dependent p-nitrophenol hydroxylation in the liver microsomes of streptozotocin-induced type 1 diabetic rats.
Effects of dapagliflozin in combination with insulin on cytochrome P450 activities in a diabetes type 1 rat model.
In Vitro Evidence for Chronic Alcohol and High Glucose Mediated Increased Oxidative Stress and Hepatotoxicity.
Knockdown of CYP1B1 suppresses the behavior of the extravillous trophoblast cell line HTR-8/SVneo under hyperglycemic condition.
Kynurenine-Induced Aryl Hydrocarbon Receptor Signaling in Mice Causes Body Mass Gain, Liver Steatosis, and Hyperglycemia.
Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats.
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.
The antidiabetic and hepatoprotective effects of magnolol on diabetic rats induced by high-fat diet and streptozotocin.
The effects of diabetes with hyperlipidemia on P450 expression in APA hamster livers.
Hyperhomocysteinemia
Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-kappabeta in hyperhomocysteinemia.
Echinocystic acid ameliorates hyperhomocysteinemia-induced vascular endothelial cell injury through regulating NF-?B and CYP1A1.
Hyperinsulinism
Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis.
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis.
Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population.
Hyperinsulinemia shifted energy supply from glucose to ketone bodies in early nonalcoholic steatohepatitis from high-fat high-sucrose diet induced Bama minipigs.
Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome.
Hyperkalemia
Nebivolol Induced Hyperkalemia: Case Report
Hyperlipidemias
A study to evaluate herb-drug interaction underlying mechanisms: An investigation of ginsenosides attenuating the effect of warfarin on cardiovascular diseases.
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
Cyclosporine-induced changes in drug metabolizing enzymes in hyperlipemic rabbit kidneys could explain its toxicity.
CYP2C9 Genetic Polymorphism is a Potential Predictive Marker for the Efficacy of Rosuvastatin Therapy.
Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance.
Effect of a high-calorie diet and constant light exposure on female reproduction, metabolism and immune inflammation: A comparative study of different mouse models.
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes.
GENERATION OF HUMAN CHIRAL METABOLITES OF SIMVASTATIN AND LOVASTATIN BY BACTERIAL CYP102A1 MUTANTS.
Higher chlorzoxazone clearance in obese children compared with nonobese peers.
Hyperlipidemia exacerbates cerebral injury through oxidative stress, inflammation and neuronal apoptosis in MCAO/reperfusion rats.
Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk.
Linderae Radix Ethanol Extract Alleviates Diet-Induced Hyperlipidemia by Regulating Bile Acid Metabolism Through gut Microbiota.
Pharmacokinetics of a cytochrome P450 2E1 probe, chlorzoxazone, and its 6-hydroxy metabolite in poloxamer 407-induced hyperlipidemic rats.
Statin therapy correlated CYP2D6 gene polymorphism and hyperlipidemia.
The antidiabetic and hepatoprotective effects of magnolol on diabetic rats induced by high-fat diet and streptozotocin.
The effects of diabetes with hyperlipidemia on P450 expression in APA hamster livers.
Hyperlipoproteinemia Type II
Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor pravastatin on urinary 6 beta-hydroxycortisol excretion: a preliminary study.
Genes Potentially Associated with Familial Hypercholesterolemia.
Late response to rosuvastatin and statin-related myalgia due to SLCO1B1, SLCO1B3, ABCB11, and CYP3A5 variants in a patient with Familial Hypercholesterolemia: a case report.
Hyperoxaluria, Primary
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Hyperparathyroidism
Diseases associated with calcium-sensing receptor.
Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats.
Hyperparathyroidism complicating CYP 24A1 mutations.
Iatrogenic vitamin D toxicity in an infant - a case report and review of literature.
Skeletal toxicity resulting from exposure of growing male rats to coplanar PCB 126 is associated with disruption of calcium homeostasis and the GH-IGF-1 axis and direct effects on bone formation.
Therapy-Resistant Hypercalcemia in a Patient with Inactivating CYP24A1 Mutation and Recurrent Nephrolithiasis: Beware of Concomitant Hyperparathyroidism.
Hyperparathyroidism, Primary
Gestational hypercalcemia: Prevalence and biochemical profile.
Ketoconazole reduces elevated serum levels of 1,25-dihydroxyvitamin D in hypercalcemic sarcoidosis.
Hyperparathyroidism, Secondary
E-pharmacophore filtering and molecular dynamics simulation studies in the discovery of potent drug-like molecules for chronic kidney disease.
Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-?B signaling pathway in secondary hyperparathyroidism.
Recent developments for introducing a hexafluoroisopropanol unit into the Vitamin D side chain.
Hyperphosphatemia
FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF23 signaling and regulating FGF23 expression in bone.
Hyperprolactinemia
CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects.
CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine.
Effects of aripiprazole on circadian prolactin secretion related to pharmacogenetics in healthy volunteers.
Hyperprolactinemia in Children and Adolescents with Use of Risperidone: Clinical and Molecular Genetics Aspects.
Impact of the CYP2D6 phenotype on hyperprolactinemia development as an adverse event of treatment with atypical antipsychotic agents in pediatric patients.
Stimulatory effects of hyperprolactinemia on aldosterone secretion in ovariectomized rats.
The effect of CYP2D6 variation on antipsychotic-induced hyperprolactinaemia: a systematic review and meta-analysis.
The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity.
Hypersensitivity
A case of hypercalcemia Indications for 1,25-dihydroxyvitamin D prescription.
Antiretroviral therapy: are we aware of adverse effects?
Application of a pharmacogenetic test adoption model to six oncology biomarkers.
Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity.
Association of CYP1B1 with hypersensitivity induced by Taxane therapy in breast cancer patients.
Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: molecular study of 11 historical IIH cases.
Calcium pyrophosphate deposition disease revealing a hypersensitivity to vitamin D.
Cutaneous metabolic activation of carvoxime, a self-activating, skin-sensitizing prohapten.
CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations.
Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications.
Differential effects of 2C9*3 and 2C9*2 variants of cytochrome P-450 CYP2C9 on sensitivity to acenocoumarol.
DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced p53-mediated apoptosis through activation of cytochrome P450/aryl hydrocarbon receptor.
Epitope mapping studies with human anti-cytochrome P450 3A antibodies.
Expression and inducibility of antigens in severe combined immunodeficient mice recognized by human anti-P450 antibodies.
Genetic variants of drug metabolizing enzymes and drug transporter (ABCB1) as possible biomarkers for adverse drug reactions in an HIV/AIDS cohort in Zimbabwe.
Hepatic Cytochrome P450 Activity and Nitric Oxide Production During Multiple Ovalbumin Challenges.
HLA Alleles and CYP2C9*3 as Predictors of Phenytoin Hypersensitivity in East Asians.
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions.
Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Human Genetic Variability and HIV Treatment Response.
In men with erectile dysfunction, satisfaction with quality of erections correlates with erection hardness, treatment satisfaction, and emotional well-being.
In silico identification of coffee genome expressed sequences potentially associated with resistance to diseases.
Increased risk of erythema multiforme major with combination anticonvulsant and radiation therapies.
Methodological and statistical issues in pharmacogenomics.
Molecular cloning and expression of a novel cytochrome p450 from Turkey liver with aflatoxin b(1) oxidizing activity.
NMDA sensitization and stimulation by peroxynitrite, nitric oxide, and organic solvents as the mechanism of chemical sensitivity in multiple chemical sensitivity.
Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions.
Nonenzymatic formation of a novel hydroxylated sulfamethoxazole derivative in human liver microsomes: implications for bioanalysis of sulfamethoxazole metabolites.
Pharmacogenetic determinants of immediate and delayed reactions of drug hypersensitivity.
Pharmacogenetics of antiretrovirals.
Pharmacogenomics: an Update for Child and Adolescent Psychiatry.
Stable expression of human CYP2E1 in Chinese hamster cells: high sensitivity to N,N-dimethylnitrosamine in cytotoxicity testing.
Temsirolimus: new drug. Metastatic kidney cancer: more assessment needed.
The Absence of CYP3A5*3 Is a Protective Factor to Anticonvulsants Hypersensitivity Reactions: A Case-Control Study in Brazilian Subjects.
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.
Topically injected adrenocorticotropic hormone induces mechanical hypersensitivity on a full-thickness cutaneous wound model in rats.
Trichloroethylene-induced hypersensitivity dermatitis was associated with hepatic metabolic enzyme genes and immune-related genes.
Unexpected acute pulmonary embolism in an old COVID-19 patient with warfarin overdose: a case report.
[Epilepsy pharmacogenetics : science or fiction?].
[Identification of a novel CYP2C9 gene mutation (1400T>C) and assessment of its enzymatic activity in vitro].
[Impact of pharmacogenetics on interindividual variability in the response to vitamin K antagonist therapy]
[Pharmacogenetics: Important aspects for dermatology]
[Relationship between gene polymorphism of CYP2E1, CYP1A1, IL-4 and medicamentosa-like der-matitis induced by trichloroethylene.]
[Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs].
Hypertension
2,3',4,5'-TETRAMETHOXYSTILBENE PREVENTS DEOXYCORTICOSTERONE-SALT-INDUCED HYPERTENSION: CONTRIBUTION OF CYTOCHROME P4501B1.
2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Vascular Dysfunction That is Dependent on Perivascular Adipose and Cytochrome P4501A1 Expression.
2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice.
20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-?B Translocation and Promoter Binding.
20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease.
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.
20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans.
6?-hydroxytestosterone, a cytochrome P450 1B1 metabolite of testosterone, contributes to angiotensin II-induced hypertension and its pathogenesis in male mice.
6?-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice.
6?-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice.
A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population.
A review of smoking cessation: potentially risky effects on prescribed medications.
A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese.
Abnormal pressure-natriuresis in hypertension: role of cytochrome P450 metabolites of arachidonic acid.
Activity of the Estrogen-Metabolizing Enzyme Cytochrome P450 1B1 Influences the Development of Pulmonary Arterial Hypertension.
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.
Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria.
Altered pharmacokinetics and excessive hypotensive effect of candesartan in a patient with the CYP2C91/3 genotype.
Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.
Angiotensin II-induced hypertension: contribution of Ras GTPase/Mitogen-activated protein kinase and cytochrome P450 metabolites.
Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease.
Arachidonic acid cytochrome P450 4F2 in hypertension: what can we learn from a transgenic mouse model??
Aripiprazole-induced atrial fibrillation in a patient with concomitant risk factors.
Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study.
Association Between CYP3A5 Polymorphisms and Blood Pressure in Kidney Transplant Recipients Receiving Calcineurin Inhibitors.
Association between daily cigarette consumption and hypertension moderated by CYP2A6 genotypes in Chinese male current smokers.
Association between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese.
Association of coffee consumption and CYP1A2 polymorphism with risk of impaired fasting glucose in hypertensive patients.
Association of CYP2D6 and ADRB1 genes with hypotensive and antichronotropic action of betaxolol in patients with arterial hypertension.
Association of CYP3A5 Gene Polymorphisms and Amlodipine-Induced Peripheral Edema in Chinese Han Patients with Essential Hypertension.
Association of CYP3A5 polymorphisms with hypertension and antihypertensive response to verapamil.
Association of cytochrome P450 1B1 gene polymorphisms and environmental biomarkers with hypertension in Slovak midlife women.
Association of the CYP3A5 polymorphism (6986G>A) with blood pressure and hypertension.
Associations between ADRB1 and CYP2D6 gene polymorphisms and the response to ?-blocker therapy in hypertension.
Associations of genetic polymorphisms of the vitamin D pathway with blood pressure in a Han Chinese population.
Brain Testosterone-CYP1B1 (Cytochrome P450 1B1) Generated Metabolite 6?-Hydroxytestosterone Promotes Neurogenic Hypertension and Inflammation.
Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension.
Calcineurin inhibitors and hypertension: a role for pharmacogenetics?
Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice.
Combined homozygous 21 hydroxylase with heterozygous P450 oxidoreductase mutation in a Saudi boy presented with hypertension.
Conflicting roles of 20-HETE in hypertension and renal end organ damage.
Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology: A novel target for antihypertensive agents.
Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME.
Contribution of Ras GTPase/MAP kinase and cytochrome P450 metabolites to deoxycorticosterone-salt-induced hypertension.
Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease.
CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension.
CYP2C9 allele variants in Chinese hypertension patients and healthy controls.
CYP3A4 and CYP3A5 polymorphisms and blood pressure response to amlodipine among African-American men and women with early hypertensive renal disease.
CYP3A5 and ABCB1 genes and hypertension.
CYP3A5 as a candidate gene for hypertension: no support from an unselected indigenous West African population.
CYP3A5 genotype is associated with diagnosis of hypertension in elderly patients: data from the DEBATE Study.
CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults.
CYP3A5 Genotype-Dependent Drug-Drug Interaction Between Tacrolimus and Nifedipine in Chinese Renal Transplant Patients.
CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men.
CYP3A5 polymorphism, amlodipine and hypertension.
Cytochrome P450 1A1 (CYP1A1) T6325C polymorphism might modulate essential hypertension-associated stroke risk.
Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology.
Cytochrome P450 1B1 contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats.
Cytochrome P450 1B1 contributes to renal dysfunction and damage caused by angiotensin II in mice.
Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice.
Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice.
Cytochrome P450 1B1 gene disruption minimizes deoxycorticosterone acetate-salt-induced hypertension and associated cardiac dysfunction and renal damage in mice.
Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire-Injured Carotid Artery of Male Mice.
Cytochrome P450 eicosanoids in cerebrovascular function and disease.
Cytochrome P450 eicosanoids in hypertension and renal disease.
Cytochrome P450 metabolites of arachidonic acid in the control of renal function.
Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system.
Cytochrome P4501A1 is required for vascular dysfunction and hypertension induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension.
Defects in cortisol metabolism causing low-renin hypertension.
Dexfenfluramine and the oestrogen metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension.
DISRUPTION OF THE CYTOCHROME P450 1B1 GENE EXACERBATES RENAL DYSFUNCTION AND DAMAGE ASSOCIATED WITH ANGIOTENSIN II-INDUCED HYPERTENSION IN FEMALE MICE.
Distributive characteristics of the CYP2C9 and AGTR1 genetic polymorphisms in Han Chinese hypertensive patients: a retrospective study.
Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.
Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II.
Effect of CYP3A51/3 polymorphism on blood pressure in renal transplant recipients.
Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology.
Effect of marine collagen peptides on markers of metabolic nuclear receptors in type 2 diabetic patients with/without hypertension.
Effect of type 2 diabetes mellitus on the pharmacokinetics and transplacental transfer of nifedipine in hypertensive pregnant women.
Effects of Commonly Administered Agents and Genetics on Nebivolol Pharmacokinetics: Drug-Drug Interaction Studies.
Eicosanoids and tumor necrosis factor-alpha in the kidney.
Estrogen metabolism by cytochrome P450 1B1 modulates the hypertensive effect of angiotensin II in female mice.
Estrogen Signaling and Portopulmonary Hypertension: The Pulmonary Vascular Complications of Liver Disease Study (PVCLD2).
Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet.
First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia.
Functional characterization of CYP2C19 variants in nebivolol 4-hydroxlation in vitro.
Functional polymorphisms in the CYP3A4, CYP3A5, and CYP21A2 genes in the risk for hypertension in pregnancy.
Gene Delivery of a Cytochrome P450 Epoxygenase Ameliorates Monocrotaline-induced Pulmonary Artery Hypertension in Rats.
Gene-environment interactions of selected pharmacogenes in arterial hypertension.
Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats.
Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.
Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.
HETEs/EETs in renal glomerular and epithelial cell functions.
Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone.
Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.
Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?
Hypertension-susceptibility gene prevalence in the Pacific Islands and associations with hypertension in Melanesia.
Identification of CYP1B1-specific candidate inhibitors using combination of in silico screening, integrated knowledge-based filtering, and molecular dynamics simulations.
Identification of Genetic Factors Underlying the Association between Sodium Intake Habits and Hypertension Risk.
IL6 suppression provides renal protection independent of blood pressure in a murine model of salt-sensitive hypertension.
Implications of cytochrome P450 interactions when prescribing medication for hypertension.
In vitro and in vivo drug-drug interaction of losartan and glimepiride in rats and its possible mechanism.
Incorporation of Gene-Environment Interaction Terms Improved the Predictive Accuracy of Tacrolimus Stable Dose Algorithms in Chinese Adult Renal Transplant Recipients.
Influence of CYP2D6 Polymorphism on the Pharmacokinetic/Pharmacodynamic Characteristics of Carvedilol in Healthy Korean Volunteers.
Influence of genetic polymorphisms of CYP3A5 and ABCB1 on sirolimus pharmacokinetics, patient and graft survival and other clinical outcomes in renal transplant.
Inhibition of renal outer medullary 20-HETE production produces hypertension in Lewis rats.
Interaction of drugs amlodipine and paroxetine with the metabolizing enzyme CYP2B4: a molecular dynamics simulation study.
Interactions Networks for Primary Heart Sarcomas.
Involvement of cytochrome P-450 1B1 in renal dysfunction, injury, and inflammation associated with angiotensin II-induced hypertension in rats.
Kidney dysfunction and hypertension: role for cadmium, p450 and heme oxygenases?
Lack of Pharmacokinetic Interactions Between Macitentan and a Combined Oral Contraceptive in Healthy Female Subjects.
Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases.
Machine learning algorithm-based risk prediction model of coronary artery disease.
Metabolism study and biological evaluation of bosentan derivatives.
Microsomal cytochrome P450 and eicosanoid metabolism.
Mutational analysis of CYP2C8 in hypertensive patients using denaturing high performance liquid chromatography.
Natural Antioxidants and Hypertension: Promise and Challenges.
No association of the CYP3A5*1 allele with blood pressure and left ventricular mass and geometry: the KORA/MONICA Augsburg echocardiographic substudy.
Nonesterified fatty acids in the pathogenesis of hypertension: theory and evidence.
Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide.
Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients - thinking of clinically relevant CYP2D6 interactions.
Pharmacokinetic interactions between indinavir plus ritonavir and calcium channel blockers.
Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Physiologic and pathophysiologic roles of lipid mediators in the kidney.
Potential for early involvement of CYP isoforms in aspects of human cadmium toxicity.
Potential for pharmacokinetic interactions between ambrisentan and cyclosporine.
Potential role of CYP1B1 in the development and treatment of metabolic diseases.
Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking.
Rapid detection of the known SNPs of CYP2C9 using oligonucleotide microarray.
Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population.
Renal and hepatic accumulation of cadmium and lead in the expression of CYP4F2 and CYP2E1.
Renal cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats.
Renal P450 metabolites of arachidonic acid and the development of hypertension in Dahl salt-sensitive rats.
Respiratory, cardiovascular and other physiological consequences of smoking cessation.
Revealing the contribution of Cytochrome P450 to salt-sensitive hypertension using DNA microarray.
Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation.
Role of CYP450 in pharmacokinetics and pharmacogenetics of antihypertensive drugs.
Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension.
Role of cytochrome P450 metabolites of arachidonic acid in hypertension.
Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension.
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.
Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension.
Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.
Testosterone Metabolite 6?-Hydroxytestosterone Contributes to Angiotensin II-Induced Abdominal Aortic Aneurysms in Apoe-/- Male Mice.
The absence of sympathoexcitation during the development of hypertension in Cyp1a1 Ren-2 transgenic rats.
The Association of ADRB1 and CYP2D6 Polymorphisms With Antihypertensive Effects and Analysis of Their Contribution to Hypertension Risk.
The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation.
The endothelin receptor antagonist macitentan for the treatment of pulmonary arterial hypertension: A cross-species comparison of its cytochrome P450 induction pattern.
The Impact of CYP24A1 Polymorphisms on Hypertension Susceptibility.
The inflammatory aspect of the microcirculation in hypertension: oxidative stress, leukocytes/endothelial interaction, apoptosis.
The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension.
The role of cytochrome P450 gene rs1126742 polymorphism and risk of hypertension: a systematic review and meta-analysis.
Three Sisters With Heterozygous Gene Variants of CYP24A1: Maternal Hypercalcemia, New-Onset Hypertension, and Neonatal Hypoglycemia.
Understanding the genetic basis for adverse drug effects: the calcineurin inhibitors.
Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans.
Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE.
Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension.
Warfarin Anticoagulation Therapy in Caribbean Hispanics of Puerto Rico: A Candidate Gene Association Study.
[Association between cytochrome p4502c9 polymorphisms and losartan dosing in hypertensive patients].
[Efficacy and safety of bisoprolol in pregnant women with chronic arterial hypertension do not depend on genetic CYP2D6 polymorphism]
[Genetic aspects of individual sensitivity to betaxolol in patients with arterial hypertension]
Hypertension, Malignant
20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats.
Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats.
Hypertension, Portal
Arachidonic acid metabolites and endothelial dysfunction of portal hypertension.
Inhibition of P-glycoprotein, multidrug resistance-associated protein 2 and cytochrome P450 3A4 improves the oral absorption of octreotide in rats with portal hypertension.
Hypertension, Pregnancy-Induced
A polymorphism in the CYP17 gene and intrauterine fetal growth restriction.
Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension.
Hypertension, Pulmonary
20-HETE-Induced Mitochondrial Superoxide and Inflammatory Phenotype in Vascular Smooth Muscle is Prevented by Glucose-6-Phosphate Dehydrogenase Inhibition.
Assessment of the effects of renal impairment and smoking on the pharmacokinetics of a single oral dose of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521).
Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling.
Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension.
Effect of monocrotaline metabolites on glutathione levels in human and bovine pulmonary artery endothelial cells.
Functional characterization of 27 CYP3A4 variants on macitentan metabolism in vitro.
Gene Delivery of a Cytochrome P450 Epoxygenase Ameliorates Monocrotaline-induced Pulmonary Artery Hypertension in Rats.
Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension.
Oestradiol metabolism and androgen receptor genotypes are associated with right ventricular function.
Pharmacokinetic interaction of riociguat with ketoconazole, clarithromycin, and midazolam.
The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1.
Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities.
[Relationship between the converting ability of liver microsomes and monocrotaline-induced pulmonary hypertension in male, female and castrated male rats]
Hypertension, Renovascular
Fenofibrate Attenuates Hypertension in Goldblatt Hypertensive Rats: Role of 20-Hydroxyeicosatetraenoic Acid in the Nonclipped Kidney.
Hyperthyroidism
Acute hyperthyroidism alters adrenoceptor- and muscarinic receptor-mediated responses in isolated rat renal and femoral arteries.
Analysis of differentially expressed genes in hyperthyroid-induced hypertrophied heart by cDNA microarray.
Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity.
Effects of methimazole on Drosophila glucolipid metabolism in vitro and in vivo.
Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach.
Enhancement of lindane-induced liver oxidative stress and hepatotoxicity by thyroid hormone is reduced by gadolinium chloride.
MATERNAL GRAVES DISEASE AND ABNORMAL CYP2D6 GENOTYPE WITH FETAL HYPERTHYROIDISM.
Role of thyroid state on induction by ciprofibrate of laurate hydroxylase and peroxisomal enzymes in rat liver microsomes.
Hypertrophy, Left Ventricular
Left Ventricular Hypertrophy: Roles of Mitochondria CYP1B1 and Melatonergic Pathways in Co-Ordinating Wider Pathophysiology.
The CYP2C9 genotype predicts the blood pressure response to irbesartan: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA) trial.
Hypoalbuminemia
Effect of hypoalbuminemia on the disposition of theophylline. Comparative study with Sprague-Dawley rats and a mutant Sprague-Dawley hyperlipidemic strain with hypoalbuminemia.
Revalidation of CoaguChek XS plus system for INR monitoring in Taiwanese patients: effects of clinical and genetic factors.
Severe verapamil intoxication despite correct use of low-dose verapamil.
Hypocalcemia
Antiepileptic drugs and bone metabolism.
Hypoglycemia
Association Between the CYP2C9 Genotype and Hypoglycemia Among Patients With Type 2 Diabetes Receiving Sulfonylurea Treatment: A Meta-analysis.
Association of KCNJ11 E23K gene polymorphism with hypoglycemia in sulfonylurea-treated Type 2 diabetic patients.
Hypoglycemia and Glycemic Control With Glyburide in Women With Gestational Diabetes and Genetic Variants of Cytochrome P450 2C9 and/or OATP1B3.
Impact of clinical factors and CYP2C9 variants for the risk of severe sulfonylurea-induced hypoglycemia.
Pharmacoepidemiologic and in Vitro Evaluation of Potential Drug-Drug Interactions of Sulfonylureas with Fibrates and Statins.
Pharmacogenetics of hypoglycemia associated with sulfonylurea therapy in usual clinical care.
Presence of CYP2C9*3 allele increases risk for hypoglycemia in Type 2 diabetic patients treated with sulfonylureas.
TCF7L2 rs7903146 C>T gene polymorphism is not associated with hypoglycemia in sulfonylurea-treated type 2 diabetic patients.
The CYP2C9 polymorphism: from enzyme kinetics to clinical dose recommendations.
The Genetics of Adverse Drug Outcomes in Type 2 Diabetes: A Systematic Review.
Three Sisters With Heterozygous Gene Variants of CYP24A1: Maternal Hypercalcemia, New-Onset Hypertension, and Neonatal Hypoglycemia.
[Status of the monooxygenase enzyme system in rat and rabbit organs in sugar diabetes and upon insulin administration]
Hypogonadism
Aromatase deficiency in a female who is compound heterozygote for two new point mutations in the P450arom gene: impact of estrogens on hypergonadotropic hypogonadism, multicystic ovaries, and bone densitometry in childhood.
Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction.
Correlation between serum P450arom and sex hormones in males with late-onset hypogonadism: a pilot study.
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Hypokalemia
Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports.
Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.
Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.
Hypokinesia
[The state of the monooxygenase enzymatic system of the rat liver in hypokinesia]
Hypophosphatemia, Familial
Transcriptional and physiological responses to chronic ACTH treatment by the mouse kidney.
Hypospadias
Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias.
Delayed diagnosis of adrenal insufficiency in a patient with severe penoscrotal hypospadias due to two novel P450 side-change cleavage enzyme (CYP11A1) mutations (p.R360W; p.R405X).
Exploiting gene-environment interaction to detect adverse health effects of environmental chemicals on the next generation.
Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter.
Maternal genetic polymorphisms in CYP1A1, GSTM1 and GSTT1 and the risk of hypospadias.
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Polymorphism in CYP1A1, GSTM 1, GSTT1 genes and organochlorine pesticides in the etiology of hypospadias.
Polymorphisms in the P450 c17 (17-Hydroxylase/17, 20-Lyase) Gene: Association with Estradiol and Testosterone Concentration in Hypospadias.
Hypotension
20-Hydroxyeicosatetraenoic acid and renal function in Lyon hypertensive rats.
5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1.
Co-prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study.
Combining Antidepressants with ?-Blockers: Evidence of a Clinically Significant CYP2D6 Drug Interaction.
Effect of potassium channel and cytochrome P450 inhibition on transient hypotension and survival during lipopolysaccharide-induced endotoxic shock in the rat.
Inhibition by nitric oxide of cytochrome P450 4A activity contributes to endotoxin-induced hypotension in rats.
Inhibition of aldosterone biosynthesis by staurosporine.
Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide.
Paraoxonase 1 in endothelial cells impairs vasodilation induced by arachidonic acid lactone metabolite.
Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production.
[Clinical survey of tizanidine-induced adverse effects--impact of concomitant drugs providing cytochrome P450 1A2 modification--].
[Psychopharmacological treatment of patients complicated with cardiovascular disease].
Hypothyroidism
Effect of thyroid hormone status and concomitant medication on statin induced adverse effects in hyperlipidemic patients.
Hepatic P450 expression in hypothyroid rats: differential responsiveness of male-specific P450 forms 2a (IIIA2), 2c (IIC11), and RLM2 (IIA2) to thyroid hormone.
Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase.
Role of thyroid state on induction by ciprofibrate of laurate hydroxylase and peroxisomal enzymes in rat liver microsomes.
Statin-associated myopathy.
THE EFFECTS OF MATERNAL HYPOTHYROIDISM ON THE IMMUNOREACTIVITY OF CYTOCHROME P450 AROMATASE IN THE POSTNATAL RAT TESTICLES.
Hypoxia-Ischemia, Brain
Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response Following Cardiac Arrest: A Comprehensive Review of Preclinical and Clinical Investigations.
Ichthyosis, Lamellar
Kava dermopathy in Fiji: an acquired ichthyosis?
Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3.
Ileus
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Illusions
A threat to a virtual hand elicits motor cortex activation.
Infarction, Middle Cerebral Artery
Cytochrome P450 CYP2E1 Suppression Ameliorates Cerebral Ischemia Reperfusion Injury.
Hyperbaric oxygenation and 20-HETE inhibition reduce stroke volume in female diabetic Sprague-Dawley rats.
Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke.
Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.
Soluble epoxide hydrolase: a novel therapeutic target in stroke.
Infections
A comparison of available and investigational antibiotics for complicated skin infections and treatment-resistant Staphylococcus aureus and enterococcus.
A new approach to cytochrome CYP2D6 antibody detection in autoimmune hepatitis type-2 (AIH-2) and chronic hepatitis C virus (HCV) infection: a sensitive and quantitative radioligand assay.
A study of hepatic mitochondrial respiration and microsomal cytochrome P450 content in mice infected with the liver fluke Fasciola hepatica.
A virus-directed enzyme prodrug therapy (VDEPT) strategy for lung cancer using a CYP2B6/NADPH-cytochrome P450 reductase fusion protein.
Absence of CYP2B6 promoter -82T>C mutation in Chinese as an additional factor for slow metabolism of drugs commonly used in infections.
Activation of promutagens in a human bronchial epithelial cell line stably expressing human cytochrome P450 1A2.
Activity of liver microsomal enzymes during the chronic phase of murine schistosomiasis.
Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1.
Ah receptor and NF-kappaB interactions: mechanisms and physiological implications.
Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: implications for impaired immune function during disease.
Alteration of drug biotransformation and elimination during infection and inflammation.
Altered decidual and placental catabolism of vitamin D may contribute to the aetiology of spontaneous miscarriage.
An integrated in vitro model for simultaneous assessment of drug uptake, metabolism, and efflux.
Antihepatotoxic properties of uridine-diphosphoglucose in liver fluke infection. Experimental fascioliasis in the rat.
Antitrypanosomal Activity of Sterol 14?-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain.
Aryl hydrocarbon receptor is required for immune response in Epinephelus coioides and Danio rerio infected by Pseudomonas plecoglossicida.
Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana.
Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease.
Baculovirus expression of human P450 2E1 and cytochrome b5: spectral and catalytic properties and effect of b5 on the stoichiometry of P450 2E1-catalyzed reactions.
Basis for the loss of aryl hydrocarbon receptor gene expression in clones of a mouse hepatoma cell line.
Biochemical properties of the products of cytochrome P450 genes (PDA) encoding pisatin demethylase activity in nectria haematococca
Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes.
Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes.
Changes in the expression of cytochrome P450 isozymes and related carcinogen metabolizing enzyme activities in Schistosoma mansoni-infected mice.
Characterization of the mouse olfactory glutathione S-transferases during the acute phase response.
Childhood nasopharyngeal carcinoma: from biology to treatment.
Clinical pharmacokinetics of quinupristin/dalfopristin.
Clinical pharmacology profile of boceprevir, a hepatitis C virus NS3 protease inhibitor: focus on drug-drug interactions.
Clinical treatment for hepatitis C reverses CYP2C19 inhibition.
Co-expression of human cytochrome P4501A1 (CYP1A1) variants and human NADPH-cytochrome P450 reductase in the baculovirus/insect cell system.
Coexpression of cytochrome P4502A6 and human NADPH-P450 oxidoreductase in the baculovirus system.
Coxsackievirus B3 infection and PBDE exposure causes organ-specific effects on CYP-gene expression in the mouse.
Cyclophosphamide treatment-induced leukopenia rates in ANCA-associated vasculitis are influenced by variant CYP450 2C9 genotypes.
CYP1A1 mediates the suppression of major inflammatory cytokines in pulmonary alveolar macrophage (PAM) cell lines caused by Mycoplasma hyponeumoniae.
CYP1A1 Relieves Lipopolysaccharide-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells.
CYP24A1 genetic variants in the vitamin D metabolic pathway are involved in the outcomes of hepatitis C virus infection among high-risk Chinese population.
CYP27A1 inhibits bladder cancer cells proliferation by regulating cholesterol homeostasis.
CYP2D6 and CYP3A4 variants influence the risk and outcome of COVID-19 infection among rheumatoid arthritis patients maintained on hydroxychloroquine.
CYP2E1 genetic polymorphism with dietary, tobacco, alcohol habits, H. pylori infection status and susceptibility to stomach cancer in Mizoram, India.
CYPome of the conifer pathogen Heterobasidion irregulare: Inventory, phylogeny, and transcriptional analysis of the response to biocontrol.
Cytochrome P450 (CYP2D6) Genotype is Associated with Elevated Systolic Blood Pressure in Preterm Infants after Discharge from the Neonatal Intensive Care Unit.
Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in reactive arthritis.
Cytochrome P450 2D6 as a model antigen.
Cytochrome P450 4F subfamily: at the crossroads of eicosanoid and drug metabolism.
Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection.
Cytochrome P450 Genes (CYP2E1 and CYP1A1) Variants and Susceptibility to Chronic Hepatitis B Virus Infection.
Cytochrome P450 isoforms. Regulation during infection, inflammation and by cytokines.
Cytochrome P450 Monooxygenases CYP6AY3 and CYP6CW1 Regulate Rice Black-Streaked Dwarf Virus Replication in Laodelphax striatellus (Fallén).
Cytochrome P450 regulation and drug biotransformation during inflammation and infection.
Decrease in brain cytochrome P450 enzyme activities during infection and inflammation of the central nervous system.
Decreased tacrolimus plasma concentrations during HCV therapy: a drug-drug interaction or is there an alternative explanation?
Detection of auto-antibodies against cytochrome P4502E1 (CYP2E1) in chronic hepatitis C.
Development of human cytochrome P450-expressing cell lines: application in mutagenicity testing of ochratoxin A.
Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection.
Different levels of Schistosoma mansoni infection increased the mutagenicity of benzo(a)pyrene, the activity of aryl hydrocarbon hydroxylase and the formation of hepatic microsomal hydrogen peroxide.
Different levels of Schistosoma mansoni infection induce changes in drug-metabolizing enzymes.
Differential effects of recombinant interferon alpha on constitutive and inducible cytochrome P450 isozymes in mouse liver.
Disseminated mycobacterium avium-intracellulare complex (MAC) infection in the era of effective antiretroviral therapy: is prophylaxis still indicated?
Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?
Down-regulation of phenobarbital-induced cytochrome P4502B mRNAs and proteins by endotoxin in mice: independence from nitric oxide production by inducible nitric oxide synthase.
Down-regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: implication of mediators in human and animal serum and in the liver.
Drug-drug interactions in the treatment of HCV among people who inject drugs.
Effect of CYP2B6 Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection.
Effect of CYP2C19 and MDR1 polymorphisms on cure rate in patients with acid-related disorders with Helicobacter pylori infection.
Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.
Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes.
Effect of Pharmacogenetics Variations on Praziquantel Plasma Concentrations and Schistosomiasis Treatment Outcomes Among Infected School-Aged Children in Tanzania.
Effect of rifampicin and clarithromycin on the CYP3A activity in patients with Mycobacterium avium complex.
Effect of Traumatic Brain Injury, Erythropoietin, and Anakinra on Hepatic Metabolizing Enzymes and Transporters in an Experimental Rat Model.
Effects of bacterial lipopolysaccharide on phenobarbital-induced CYP2B expression in mice.
Effects of coxsackievirus B3 infection on the acute-phase protein metallothionein and on cytochrome P-4501A1 involved in the detoxification processes of TCDD in the mouse.
Effects of CYP3A5 Polymorphisms on Efficacy and Safety of Tacrolimus Therapy in Patients with Idiopathic Membranous Nephropathy.
Effects of experimental dicrocoeliosis on oxidative drug metabolism in hamster liver.
Efficient complementary DNA directed expression of human fetal liver cytochrome P450 (CYP3A7) in insect cells using baculovirus.
Establishment of a novel radioligand assay using eukaryotically expressed cytochrome P4502D6 for the measurement of liver kidney microsomal type 1 antibody in patients with autoimmune hepatitis and hepatitis C virus infection.
Estrogen Metabolism-Associated CYP2D6 and IL6-174G/C Polymorphisms in Schistosoma haematobium Infection.
Ethanol-related cytotoxicity catalyzed by CYP2E1-dependent generation of reactive oxygen intermediates in transduced HepG2 cells.
Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to Mycobacterium tuberculosis.
Expanding the canon: Non-classical mosquito genes at the interface of arboviral infection.
Exposure to sublethal doses of fipronil and thiacloprid highly increases mortality of honeybees previously infected by Nosema ceranae.
Expression of cytochromes P450 4F4 and 4F5 in infection and injury models of inflammation.
EXPRESSION OF UDP-GLUCURONOSYLTRANSFERASE ISOFORM mRNAS DURING INFLAMMATION AND INFECTION IN MOUSE LIVER AND KIDNEY.
Factors involved in the down-regulation of cytochrome P450 during Listeria monocytogenes infection.
Feedback control of AHR signalling regulates intestinal immunity.
Field studies of aflatoxin exposure, metabolism and induction of genetic alterations in relation to HBV infection and hepatocellular carcinoma in The Gambia and Thailand.
Fungal Lanosterol 14?-demethylase: A target for next-generation antifungal design.
Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes.
Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection.
Genetic polymorphisms of the cancer related gene and Helicobacter pylori infection in Japanese gastric cancer patients. An age and gender matched case-control study.
Genome and transcriptome analysis of the latent pathogen Lasiodiplodia theobromae, an emerging threat to the cacao industry.
Genome-Wide Identification and Analysis of Chitinase GH18 Gene Family in Mycogone perniciosa.
Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection.
Glutathione Transferase and Cytochrome P450 (General Oxidase) Activity Levels in Candidatus Liberibacter Asiaticus-Infected and Uninfected Asian Citrus Psyllid (Hemiptera: Psyllidae)
Gut Transcription in Helicoverpa zea is Dynamically Altered in Response to Baculovirus Infection.
HBV/HCV Infection, Alcohol, Tobacco and Genetic Polymorphisms for Hepatocellular Carcinoma in Nagoya, Japan.
Helicobacter pylori infection, but not genetic polymorphism of CYP2E1, is highly prevalent in gastric cancer patients younger than 40 years.
Hepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice.
Hepatic cytochrome P450 and related drug biotransformation during an outbreak of mouse hepatitis virus in a colony of Swiss BALB/c mice.
Hepatic drug metabolism and immunostimulation.
Hepatic microsomal cytochrome P450 system during experimental hookworm infection.
Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China.
Herbal extracts used for upper respiratory tract infections: are there clinically relevant interactions with the cytochrome P450 enzyme system?
Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease.
High Plasma Efavirenz Concentration and CYP2B6 Polymorphisms in Thai HIV-1 Infections.
Human CYP1A1 allelic variants: baculovirus expression and purification, hydrodynamic, spectral, and catalytical properties and their potency in the formation of all-trans-retinoic acid.
Iatrogenic hypercortisolism complicating triamcinolone acetonide injections in patients with HIV on ritonavir-boosted protease inhibitors.
Identification and expression profile of the soil moisture and Ralstonia solanacearum response CYPome in ginger (Zingiber officinale).
Identification of Differentially Expressed Proteins in Sugarcane in Response to Infection by Xanthomonas albilineans Using iTRAQ Quantitative Proteomics.
Identification of Genes Expressed Differentially in Grapefruit Infected with Candidatus Liberibacter asiaticus in the Late Stage of Disease
Immune response following liver transplantation compared to kidney transplantation: usefulness of monitoring peripheral blood CD4+ adenosine triphosphate activity and cytochrome P450 3A5 genotype assay.
Impact of CYP2R1, CYP27A1 and CYP27B1 genetic polymorphisms controlling vitamin D metabolism on susceptibility to hepatitis C virus infection in a high-risk Chinese population.
In planta transcriptome analysis reveals tissue-specific expression of pathogenicity genes and microRNAs during rice-Magnaporthe interactions.
In Planta Variation of Volatile Biosynthesis: An Alternative Biosynthetic Route to the Formation of the Pathogen-Induced Volatile Homoterpene DMNT via Triterpene Degradation in Arabidopsis Roots.
In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex.
Individuals having variant genotypes of cytochrome P450 2C19 are at increased risk of developing primary liver cancer in Han populations, without infection with the hepatitis virus.
Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini.
Infection of rats with Taenia taeniformis metacestodes increases hepatic CYP450, induces the activity of CYP1A1, CYP2B1 and COH isoforms and increases the genotoxicity of the procarcinogens benzo[a]pyrene, cyclophosphamide and aflatoxin B(1).
Influence of chronic hepatitis C infection on cytochrome P450 3a4 activity using midazolam as an in vivo probe substrate.
Influence of Mycoplasma arginini infection on the induction of aryl hydrocarbon hydroxylase by TCDD in rat hepatoma cell cultures.
Influencing Factors for Cure of Clonorchiasis by Praziquantel Therapy: Infection Burden and CYP3A5 Gene Polymorphism.
Integrin Receptors Play a Key Role in the Regulation of Hepatic Cytochrome P450 3A.
Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule.
Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners.
Lipopolysaccharide evokes the modulation of brain cytochrome P4501A in the rat.
Listeriosis downregulates hepatic cytochrome P450 enzymes in sublethal murine infection.
Liver glutathione and cytochrome P450 activity in experimental infection: study of the relative effects of infectious stress and malnutrition.
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection.
Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation.
Long-term clinical safety of Clindamycin and Rifampicin combination for the treatment of Hidradenitis suppurativa: a critically appraised topic.
Long-term enhancement of cytochrome P450 2B1/2 expression in rat hepatocyte spheroids through adenovirus-mediated gene transfer.
Mechanism of hepatic cytochrome P450 modulation during Listeria monocytogenes infection in mice.
Mechanism of impairment of cytochrome P450-dependent metabolism in hamster liver during leishmaniasis.
Mechanisms of cytochrome P450 regulation by inflammatory mediators.
Medication use and medical comorbidity in patients with chronic hepatitis C from a US commercial claims database: high utilization of drugs with interaction potential.
Modulation of cytochrome P450 by inflammation in astrocytes.
Modulation of expression and activity of cytochrome P450s and alteration of praziquantel kinetics during murine schistosomiasis.
Modulation of hepatic cytochrome P450 during Listeria monocytogenes infection of the brain.
Modulation of hepatic cytochrome P450s by citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice.
Modulatory effect of hyperthermia on hepatic microsomal cytochrome P450 in mice.
Molecular Characterization and Functional Analysis of Three Pathogenesis-Related Cytochrome P450 Genes from Bursaphelenchus xylophilus (Tylenchida: Aphelenchoidoidea).
Mouse Forkhead L2 (FOXL2) maintains repression of FSH-dependent genes in the granulosa cell.
Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation.
Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli.
No Clinical Impact of CYP3A5 Gene Polymorphisms on the Pharmacokinetics and/or Efficacy of Maraviroc in Healthy Volunteers and HIV-1-Infected Subjects.
Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir: A Review in Chronic HCV Genotype 1 Infection.
Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
Optimal management of peptic ulcer disease in the elderly.
Overexpression of CYP2E1 enhances sensitivity of hepG2 cells to fas-mediated cytotoxicity.
Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome.
PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.
Pharmacogenetic associations with cytochrome P450 in antiretroviral therapy: what does the future hold?
Pharmacogenetic Markers of CYP2B6 Associated with Efavirenz Plasma Concentrations in HIV-1 infected Thai Adults.
Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based combination therapy with primaquine.
Plasmodium berghei (ANKA): infection induces CYP2A5 and 2E1 while depressing other CYP isoforms in the mouse liver.
Polymorphism of CYPIA1 and GSTM1 genes associated with susceptibility of gastric cancer in Shandong Province of China.
Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India.
Polymorphisms and the pocketbook: the cost-effectiveness of cytochrome P450 2C19 genotyping in the eradication of Helicobacter pylori infection associated with duodenal ulcer.
Porphyria cutanea tarda.
Possible isozyme-specific effects of experimental malaria infection with Plasmodium berghei on cytochrome P450 activity in rat liver microsomes.
Prevalence of CYP2D6 Genotypes and Predicted Phenotypes in a Cohort of Cambodians at High Risk for Infections with Plasmodium vivax.
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study.
Regulation of cytochrome p450 by inflammatory mediators: why and how?
Regulation of cytochromes P450 during inflammation and infection.
Regulation of Drug Metabolizing Enzymes and Transporters in Inflammation.
Regulation of drug-metabolizing enzymes and transporters in inflammation.
Regulation of hepatic cytochrome P450 expression in mice with intestinal or systemic infections of citrobacter rodentium.
Regulation of NAD(P)H:quinone oxidoreductase 1 gene expression by CYP1A1 activity.
Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis C virus replicon-expressing cells.
Repression of Hepatic Cytochrome P450 2D Expression in Mice during Babesia microti Infection.
Response of the ileum transcriptome to fructo-oligosaccharides in Taiping chickens.
Reverse type I inhibitor of Mycobacteriumtuberculosis CYP125A1.
Rhabdomyolysis in an HIV-Infected Patient on Anti-Retroviral Therapy Precipitated by High-Dose Pravastatin.
Ritonavir and Topical Ocular Corticosteroid Induced Cushing's Syndrome in an Adolescent with HIV-1 Infection.
Role of nitric oxide in the inhibition of cytochrome P450 in the liver of mice infected with Chlamydia trachomatis.
Role of the pepper cytochrome P450 gene CaCYP450A in defense responses against microbial pathogens.
Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes.
Selective Modulation of Hepatic Cytochrome P450 and Flavin Monooxygenase 3 Expression during Citrobacter rodentium Infection in Severe Combined Immune-Deficient Mice.
Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Sera of children with hepatitis C infection and anti-liver-kidney microsome-1 antibodies recognize different CYP2D6 epitopes than adults with LKM+/HCV+ sera.
Short communication: Vitamin D status and responses in dairy cows naturally infected with Mycobacterium avium ssp. paratuberculosis.
Short-term inhibitory effects of nitric oxide on cytochrome P450-mediated drug metabolism: time dependency and reversibility profiles in isolated perfused rat livers.
Some aspects of interindividual variations in the metabolism of xenobiotics.
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
Studies on drug metabolizing enzymes during arteether treatment of Plasmodium yoelii nigeriensis infected mice cerebral microvessels.
Suppression of cytochrome P450- and UDP glucuronosyl transferase-dependent enzyme activities by proinflammatory cytokines and possible role of nitric oxide in primary cultures of pig hepatocytes.
Telithromycin: new preparation. A needless addition to the other macrolides.
Temporal Transcription Profiling of Sweet Orange in Response to PthA4-Mediated Xanthomonas citri subsp. citri Infection.
Temsirolimus and mantle cell lymphoma. Highly toxic, limited efficacy.
Temsirolimus: new drug. Metastatic kidney cancer: more assessment needed.
The effect of ivermectin alone and in combination with cobicistat or elacridar in experimental Schistosoma mansoni infection in mice.
The Enhanced Immune Protection in Small Abalone Haliotis diversicolor Against a Secondary Infection With Vibrio harveyi.
The relative importance of Ah versus H-2 genotype on Trichinella resistance following exposure to 3-methylcholanthrene.
The Role of Cytochromes P450 in Infection.
The role of cytokines in the depression of CYP1A activity using cultured astrocytes as an in vitro model of inflammation in the central nervous system.
The structure of Mycobacterium tuberculosis CYP125: Molecular basis for cholesterol binding in a P450 needed for host infection.
Time-dependent amplified pharmacokinetic and pharmacodynamic responses of rabeprazole in cytochrome P450 2C19 poor metabolizers.
TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease.
Tocilizumab: new drug. Rheumatoid arthritis: another 'mab', no therapeutic advantage.
Toxic rise of clozapine plasma concentrations in relation to inflammation.
Transcriptional regulation of the grape cytochrome P450 monooxygenase gene CYP736B expression in response to Xylella fastidiosa infection.
Transcriptional Responses of the Trichoplusia ni Midgut to Oral Infection by the Baculovirus Autographa californica Multiple Nucleopolyhedrovirus.
Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica.
Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study.
Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria models.
Up-regulation of glutathione S-transferases alpha by interleukin 4 in human hepatocytes in primary culture.
Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver.
Viral infection induces different detoxification enzyme activities in insecticide-resistant and -susceptible brown planthopper Nilaparvata lugens strains.
Vitamin-D: An innate antiviral agent suppressing Hepatitis C virus in human hepatocytes.
Voriconazole metabolism is influenced by severe inflammation: a prospective study.
When Should Statins Be Stopped?
Xenobiotic-metabolizing enzymes in carp (Cyprinus carpio) liver, spleen, and head kidney following experimental Listeria monocytogenes infection.
[CYP2D6*1, CYP2D6*10 co-expressed with CYPOR in Bac-to-Bac expression system and activity determination].
[Effects of chronic HBV infection on human hepatic cytochrome P450 3A4]
[Increased Clozapine Levels During Infection: more Frequent than Assumed?]
[Non aromatic hydrocarbon receptor dependent regulatory mechanism of cytochrome P4501A1 and its role in infection and inflammation].
[Pharmacokinetic interactions of telaprevir with other drugs].
[Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced influenza-virus-associated encephalopathy]
Infertility
Analysis of GSTM1, GSTT1, and CYP1A1 in Idiopathic Male Infertility.
Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1.
Association between single nucleotide polymorphism of the CYP19A1 and ESR2 genes and endometriosis.
Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility.
Association of FSH receptor and CYP19A1 gene variations with sterility and ovarian hyperstimulation syndrome.
CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women.
Cytochrome P-450 1B1 Leu432Val Polymorphism Does Not Show Association With Breast Cancer in Northern Iranian Women With a History of Infertility.
Effect of Lepidium meyenii (maca) on testicular function of mice with chemically and physically induced subfertility.
Estrogen promotes Leydig cell engulfment by macrophages in male infertility.
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis.
Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues.
Genetic mutations resulting in estrogen insufficiency in the male.
Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue.
Genetic Polymorphism of CYP2D6 and Clomiphene Concentrations in Infertile Patients with Ovulatory Dysfunction Treated with Clomiphene Citrate.
Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites.
High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome.
Interactions between urinary 4-tert-octylphenol levels and metabolism enzyme gene variants on idiopathic male infertility.
Liver receptor homologue-1 and steroidogenic factor-1 expression in cultured granulosa cells from patients with endometriosis: A preliminary study.
Scrambled and fried: Cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress.
Smoking status modifies the relation between CYP1A1*2C gene polymorphism and idiopathic male infertility: the importance of gene-environment interaction analysis for genetic studies of the disease.
SNP's in xenobiotic metabolism and male infertility.
[Cytochrome p450 genes and their application in plant improvement]
[Diagnostic value of the detection of aromatase cytochrome P450 and CA125 for endometriosis]
Infertility, Female
Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues.
Infertility, Male
Analysis of GSTM1, GSTT1, and CYP1A1 in Idiopathic Male Infertility.
Association between 3801T>C polymorphism of CYP1A1 and idiopathic male infertility risk: a systematic review and meta-analysis.
Association between CYP1A1 rs4646903 T > C genetic variations and male infertility risk: A meta-analysis.
Association between CYP1A1 rs4646903 T > C genetic variations and male infertility risk: A meta-analysis: Erratum.
Association of CYP1A1*2A polymorphism with male infertility in Indian population.
Association of MTHFR, NFKB1, NFKBIA, DAZL and CYP1A1 gene polymorphisms with risk of idiopathic male infertility in a Han Chinese population.
Combined effects of urinary phytoestrogens metabolites and polymorphisms in metabolic enzyme gene on idiopathic male infertility.
Disturbed testicular expression of the estrogen-metabolizing enzymes CYP1A1 and COMT in infertile men with primary spermatogenic failure: possible negative implications on Sertoli cells.
Effect of CYP1A1 gene polymorphism and psychological distress on seminal analysis parameters.
Estrogen promotes Leydig cell engulfment by macrophages in male infertility.
Polymorphisms in CYP1A1 gene are associated with male infertility in a Chinese population.
Polymorphisms in CYP1B1 modify the risk of idiopathic male infertility with abnormal semen quality.
Quantitative analysis of CCR5 chemokine receptor and cytochrome P450 aromatase transcripts in swim-up spermatozoa isolated from fertile and infertile men.
Re: Analysis of GSTM1, GSTT1, and CYP1A1 in Idiopathic Male Infertility.
Smoking status modifies the relation between CYP1A1*2C gene polymorphism and idiopathic male infertility: the importance of gene-environment interaction analysis for genetic studies of the disease.
SNP's in xenobiotic metabolism and male infertility.
Targeted Mutagenesis of a Conserved Anther-Expressed P450 Gene Confers Male Sterility in Monocots.
The Cytochrome P4501A1 gene polymorphisms and idiopathic male infertility risk: a meta-analysis.
Transcriptome analysis identified aberrant gene expression in pollen developmental pathways leading to CGMS in cotton (Gossypium hirsutum L.).
Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis.
Two duplicate CYP704B1 homologous genes BnMs1 and BnMs2 are required for pollen exine formation and tapetal development in Brassica napus.
Using Transcriptome Analysis to Screen for Key Genes and Pathways Related to Cytoplasmic Male Sterility in Cotton (Gossypium hirsutum L.).
[CYP1A1 rs4646422 gene polymorphisms not correlated with male infertility in Chinese Han population].
Inflammatory Bowel Diseases
Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis.
Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in the rat model of dextran sulfate sodium-induced experimental colitis.
Genetic Polymorphisms of CYP2D6 Oxidation in Patients with Inflammatory Bowel Disease.
How autophagy controls the intestinal epithelial barrier.
Significance of the genetic polymorphism of CYP2D6 and NAT2 in patients with inflammatory bowel diseases.
TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease.
Inflammatory Breast Neoplasms
Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-?-catenin signalling, the stem cell phenotype and disease progression.
Influenza, Human
CYP2E1 activity is not altered by influenza vaccination.
Effect of age and degree of immune activation on cytochrome P450 3A4 activity after influenza immunization.
Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice.
Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1.
Influenza immunization does not predominantly alter levels of phenytoin, and cytochrome P-450 enzymes in epileptic patients receiving phenytoin monotherapy.
Influenza vaccination and warfarin anticoagulation.
[Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced influenza-virus-associated encephalopathy]
Insulin Resistance
20-HETE Interferes with Insulin Signaling and Contributes to Obesity-Driven Insulin Resistance.
20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans.
A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese.
Acupuncture does not ameliorate metabolic disturbances in the P450 aromatase inhibitor-induced rat model of polycystic ovary syndrome.
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
Associations between plasma clozapine/N-desmethylclozapine ratio, insulin resistance and cognitive performance in patients with co-morbid obesity and ultra-treatment resistant schizophrenia.
Author Correction: Effect of BI-1 on insulin resistance through regulation of CYP2E1.
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis.
CHIP(-/-)-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications.
CYP2E1 Impairs GLUT4 Gene Expression and Function: NRF2 as a Possible Mediator.
Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance.
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Cytochrome P450 activity and endothelial dysfunction in insulin resistance.
Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans.
Effect of BI-1 on insulin resistance through regulation of CYP2E1.
Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA?treated HepG2 cells.
Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis.
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.
High-calorie diet inflates steatogenic effects of valproic acid in mice.
Impact of CYP1A2 and CYP2D6 polymorphisms on drug metabolism and on insulin and lipid elevations and insulin resistance in clozapine-treated patients.
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role.
Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy.
Inhibition of CYP4A Reduces Hepatic Endoplasmic Reticulum Stress and Features of Diabetes in Mice.
Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells.
Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome.
Metformin, Estrogen Replacement Therapy and Gonadotropin Inhibition Fail to Improve Insulin Sensitivity in a Girl with Aromatase Deficiency.
Overexpression of cholesterol 7?-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis.
Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease.
Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation.
Regulation of expression of the rodent cytosolic sulfotransferases.
Reliability of total overnight salivary caffeine assessment (TOSCA) for liver function evaluation in compensated cirrhotic patients.
Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD(+) /NADH ratio.
Role of CYP2C9 polymorphism in phenytoin-related metabolic abnormalities and subclinical atherosclerosis in young adult epileptic patients.
Steatohepatitis induced by intragastric overfeeding in mice.
The antidiabetic and hepatoprotective effects of magnolol on diabetic rats induced by high-fat diet and streptozotocin.
The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats.
The preventive effects of aspirin on preeclampsia based on network pharmacology and bioinformatics.
The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process.
The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases.
Transcriptome sequencing identifies key pathways and genes involved in gastric adenocarcinoma.
Intellectual Disability
Cerebrotendinous xanthomatosis, a metabolic disease with different neurological signs: two case reports.
Intermittent Claudication
Cilostazol: new drug. Intermittent claudication: too little efficacy, too many risks.
Invasive Fungal Infections
Effects of CYP3A4 polymorphisms on the plasma concentration of voriconazole.
Impact of CYP2C19 Genotype and Drug Interactions on Voriconazole Plasma Concentrations: A Spain Pharmacogenetic-Pharmacokinetic Prospective Multicenter Study.
Impact of CYP2C19 Phenotype and Drug-Drug Interactions on Voriconazole Concentration in Pediatric Patients.
Novel insights into the complex pharmacokinetics of voriconazole: a review of its metabolism.
Iron Deficiencies
Effects of different degrees of iron deficiency on cytochrome P450 complex and pentose phosphate pathway dehydrogenases in the rat.
[Effect of dietary iron deficiency on the activity of the monooxygenase system of rat liver microsomes and its induction by phenobarbital]
Iron Overload
Effects of phlebotomy therapy on cytochrome P450 2e1 activity and oxidative stress markers in dysmetabolic iron overload syndrome: a randomized trial.
Hepatotoxicity induced by iron overload and alcohol. Studies on the role of chelatable iron, cytochrome P450 2E1 and lipid peroxidation.
Hyperinsulinemia shifted energy supply from glucose to ketone bodies in early nonalcoholic steatohepatitis from high-fat high-sucrose diet induced Bama minipigs.
Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans.
Mild iron overload effect on rat liver nuclei.
Porphyria cutanea tarda.
Role of CYP1A1, ABCG2, CYP24A1 and VDR gene polymorphisms on the evaluation of cardiac iron overload in thalassaemia patients.
Role of iron in alcoholic liver disease: introduction and summary of the symposium.
Irritable Bowel Syndrome
Implications of Pharmacogenomics to the Management of IBS.
Pharmacogenomics and functional gastrointestinal disorders.
Ischemic Attack, Transient
Does CYP2C19 polymorphisms affect neurological deterioration in stroke/TIA patients?: A systematic review and meta-analysis of prospective cohort studies.
Effect of ticagrelor with clopidogrel on high on-treatment platelet reactivity in acute stroke or transient ischemic attack (PRINCE) trial: Rationale and design.
Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack.
Ischemic Stroke
20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis.
Association between CYP2C9 polymorphisms and ischemic stroke following endovascular neurointervention.
Association between cytochrome P450 promoter polymorphisms and ischemic stroke.
Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese.
Association of CYP1A1 Gene Polymorphism with Ischemic Stroke in South Indian Population.
Association of CYP3A4*1G and CYP3A5*3 With the 1-year Outcome of Acute Ischemic Stroke in the Han Chinese Population.
Association of Cytochrome P450 Genetic Variants with Clopidogrel Resistance and Outcomes in Acute Ischemic Stroke.
Association of cytochrome P4502E1 and NAD(P)H:quinone oxidoreductase 1 genetic polymorphisms with susceptibility to large artery atherosclerotic ischemic stroke: a case-control study in the Turkish population.
Astrocytic cytochrome P450 4A/20-hydroxyeicosatetraenoic acid contributes to angiogenesis in the experimental ischemic stroke.
Clopidogrel preventive effect based on cytochrome P450 2C19 genotype in ischaemic stroke: protocol for multicentre observational study.
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
CYP2B6 Polymorphisms Are Associated with Ischemic Stroke Risk in a Chinese Han Population.
CYP2C8 rs17110453 and EPHX2 rs751141 two-locus interaction increases susceptibility to ischemic stroke.
Cytochrome P450 Genetic Variants and Their Metabolite Levels Associated with Plaque Stability in Patients with Ischemic Stroke.
Cytochrome P4501A1 genotypes and smoking- and hypertension-related ischemic stroke risk.
Effect of CYP2C9 *11/*11 genotype on initial and long-term warfarin dose requirement and therapeutic response.
Effects of Triflusal and Clopidogrel on the Secondary Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping.
Genetic Polymorphisms of ALOX5AP and CYP3A5 Increase Susceptibility to Ischemic Stroke and Are Associated with Atherothrombotic Events in Stroke Patients.
Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke.
Genotypes of vitamin K epoxide reductase, gamma-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.
Increased P450 aromatase levels in post-menopausal women after acute ischemic stroke.
Influence of cytochrome P450 2C9*2 and 2C9*3 variants on the risk of ischemic stroke: a cross-sectional case-control study.
Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients.
Interaction among CYP2C8, EPHX2, and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke in Chinese Populations.
Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke.
Interactive Association Between CYP2C9 rs2860905 Polymorphism and Atrial Fibrillation on Ischemic Stroke in Taiwan Biobank Participants.
Metabolomic profiling of fatty acid biomarkers for intracerebral hemorrhage stroke.
Protocol for the comparison of triflusal and clopidogrel in secondary prevention of stroke based on cytochrome P450 2C19 genotyping (MASETRO study): A multicenter, randomized, open-label, parallel-group trial.
The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population.
The association of CYP1A1 genetic polymorphisms and additional gene-gene interaction with ischemic stroke in the eastern Han of China.
Jaw Cysts
Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome.
Keloid
Enhanced expression of membrane transporter and drug resistance in keloid fibroblasts.
Keratosis, Actinic
Activation and overexpression of the aryl hydrocarbon receptor contribute to cutaneous squamous cell carcinomas: an immunohistochemical study.
Ketosis
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Heinz body formation associated with ketoacidosis in diabetic cats.
Pretranslational activation of cytochrome P450IIE during ketosis induced by a high fat diet.
The effects of non-esterified fatty acids and ?-hydroxybutyrate on the hepatic CYP2E1 in cows with clinical ketosis.
Kidney Calculi
A rapid screening of a recurrent CYP24A1 pathogenic variant opens the way to molecular testing for Idiopathic Infantile Hypercalcemia (IIH).
Kidney function and influence of sunlight exposure in patients with impaired 24-hydroxylation of vitamin D due to CYP24A1 mutations.
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Maternal and infantile hypercalcemia caused by vitamin-D-hydroxylase mutations and vitamin D intake.
Kidney Diseases
CYP24A1 and kidney disease.
CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases.
CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients.
CYP3A4 and CYP3A5 polymorphisms and blood pressure response to amlodipine among African-American men and women with early hypertensive renal disease.
Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress.
Down-regulation of hepatic CYP3A and CYP2C mediated metabolism in rats with moderate chronic kidney disease.
Effect of renal impairment on the pharmacokinetics of bupropion and its metabolites.
Enhanced induction of Cyp24a1 by FGF23 but low serum 24,25-dihydroxyvitamin D in CKD: implications for therapy.
Epoxyeicosatrienoic acids: a double-edged sword in cardiovascular diseases and cancer.
ESRD impairs nonrenal clearance of fexofenadine but not midazolam.
HETEs/EETs in renal glomerular and epithelial cell functions.
Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies.
Metabolism and disposition kinetics of nicotine.
Proton Pump Inhibitor-Induced Galactorrhea in a Kidney Transplant Recipient: A Friend or Foe?
The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes.
The Uremic Toxin Indoxyl-3-Sulfate Induces CYP1A2 In Primary Human Hepatocytes.
Ultra-rare renal diseases diagnosed with whole-exome sequencing: Utility in diagnosis and management.
Use of Enantiomeric Bupropion and Hydroxybupropion to Assess CYP2B6 Activity in Glomerular Kidney Diseases.
Kidney Diseases, Cystic
20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.
Kidney Failure, Chronic
Altered nonrenal drug clearance in ESRD.
Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: comparison of sparteine and dextromethorphan.
Association of CYP3A5 polymorphisms and parathyroid hormone with blood level of tacrolimus in patients with end-stage renal disease.
Clinical determinants of calcineurin inhibitor disposition: a mechanistic review.
CYP2D6, GST-M1 and GST-T1 enzymes: expression in parathyroid gland and association with the parathyroid hormone concentration during early renal replacement therapy.
CYP3A5 polymorphism affects the increase in CYP3A activity after living kidney transplantation in patients with end stage renal disease.
Down-regulation of hepatic cytochrome p450 in chronic renal failure: role of uremic mediators.
Downregulation of hepatic cytochrome P450 in chronic renal failure.
Downregulation of intestinal cytochrome p450 in chronic renal failure.
Effect of uremic serum and uremic toxins on drug metabolism in human microsomes.
Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats.
Effects of chronic renal failure on kidney drug transporters and cytochrome p450 in rats.
Effects of chronic renal failure on liver drug transporters.
Effects of decreased vitamin D and accumulated uremic toxin on human CYP3A4 activity in patients with end-stage renal disease.
Effects of serum from patients with chronic renal failure on rat hepatic cytochrome P450.
End-stage renal disease reduces the expression of drug-metabolizing cytochrome P450s.
Impaired Vitamin D Signaling Is Associated With Frequent Development of Renal Cell Tumor in End-stage Kidney Disease.
Influence of the CYP2D6 polymorphism and hemodialysis on codeine disposition in patients with end-stage renal disease.
Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease.
Long-term outcome of the survivors of infantile hypercalcaemia with CYP24A1 and SLC34A1 mutations.
Possibility of Decrease in CYP1A2 Function in Patients With End-Stage Renal Disease.
Recovery of CYP3A Phenotype Following Kidney Transplantation.
Role of parathyroid hormone in the downregulation of liver cytochrome P450 in chronic renal failure.
Significance of L-carnitine in internal medicine.
The effect of chronic renal failure on drug metabolism and transport.
Upregulation of cytochrome P450 1A2 in chronic renal failure: does oxidized tryptophan play a role?
Utilizing physiologically based pharmacokinetic modeling to predict theoretically conceivable extreme elevation of serum flecainide concentration in an anuric hemodialysis patient with cirrhosis.
Kidney Neoplasms
Aryl hydrocarbon receptor activation by aminoflavone: new molecular target for renal cancer treatment.
Association of CYP1B1 L432V polymorphism with urinary cancer susceptibility: a meta-analysis.
CYP24A1 rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System.
Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells.
Relationship Between CYP1A1 Genetic Polymorphisms and Renal Cancer in China.
Kwashiorkor
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test.
The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor.
lactase deficiency
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Laryngeal Neoplasms
Aryl hydrocarbon hydroxylase in persons with lung or laryngeal cancer.
Association between CYP1B1 gene polymorphisms and risk factors and susceptibility to laryngeal cancer.
Association between early-onset breast and laryngeal cancers.
CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx.
CYP1A1 rs1048943 and rs4646903 polymorphisms associated with laryngeal cancer susceptibility among Asian populations: a meta-analysis.
Effects of CYP2D6 activity and tobacco on larynx cancer risk.
Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients.
Genotype of Null Polymorphisms in Genes GSTM1, GSTT1, CYP1A1, and CYP1A1*2A (rs4646903 T>C)/CYP1A1*2C (rs1048943 A>G) in Patients with Larynx Cancer in Southeast Spain.
Laryngeal cancer, aryl hydrocarbon hydroxylase inducibility and smoking. A follow-up study.
Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses.
Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract.
The association of the CYP1A1 Ile462Val polymorphism with head and neck cancer risk: evidence based on a cumulative meta-analysis.
The polymorphism of CYP2E1 Rsa I/Pst I gene and susceptibility to respiratory system cancer: a systematic review and meta-analysis of 34 studies.
[Genetic polymorphism of cytochrome P4501A1 and susceptibility to laryngeal carcinoma]
[Relationship between susceptibility and prognosis of laryngeal cancer and genetic polymorphisms in CYP1A1 and GSTM1]
[Role of aryl hydrocarbon hydroxylase in developing laryngeal cancer among smokers]
Latent Tuberculosis
CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis.
Leiomyoma
Aromatase expression in endometriosis.
Association of polymorphisms and haplotypes in the cytochrome P450 1B1 gene with uterine leiomyoma: A case control study.
Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells.
Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study.
CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women.
CYP1A1 genetic polymorphisms and uterine leiomyoma risk: a meta-analysis.
CYP24A1 expression analysis in uterine leiomyoma regarding MED12 mutation profile.
Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity.
Ectopic expression of CYP24A1 circular RNA hsa_circ_0060927 in uterine leiomyomas.
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
Expression of the CYP19 gene and its product aromatase cytochrome P450 in human uterine leiomyoma tissues and cells in culture.
Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas.
Haplotypes of CYP1B1 and CCDC57 genes in an Afro-Caribbean female population with uterine leiomyoma.
High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome.
Human uterine leiomyoma contains low levels of 1, 25 dihdroxyvitamin D3, and shows dysregulated expression of vitamin D metabolizing enzymes.
In situ estrogen synthesized by aromatase P450 in uterine leiomyoma cells promotes cell growth probably via an autocrine/intracrine mechanism.
Inhibition of in situ expression of aromatase P450 in leiomyoma of the uterus by leuprorelin acetate.
Is genetic polymorphism of ER-alpha, CYP1A1, and CYP1B1 a risk factor for uterine leiomyoma?
Lack of Association Between ESR1 and CYP1A1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent.
Leu/Val SNP polymorphism of CYP1B1 and risk of uterine leiomyoma in a Black population.
Overexpression of aromatase P450 in leiomyoma tissue is driven primarily through promoter I.4 of the aromatase P450 gene (CYP19).
Polymorphisms of CYP17A1, CYP19, and androgen in Brazilian women with uterine leiomyomas.
Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium.
The role of MSP I CYP1A1 gene polymorphism in the development of uterine fibroids.
Uterine leiomyomas express a molecular pattern that lowers retinoic acid exposure.
[Effects of metformin on the expression of estrogen synthetase and ER mRNA in uterine leiomyoma tissues].
Leiomyosarcoma
Steroid hormones modulate expression of cytochrome P450 enzymes in male hamster reproductive tract and leiomyosarcomas.
Leishmaniasis
Mechanism of impairment of cytochrome P450-dependent metabolism in hamster liver during leishmaniasis.
Leishmaniasis, Visceral
Impact of visceral leishmaniasis and curative chemotherapy on cytochrome P450 activity in Brazilian patients.
Leprosy
An enlarged, adaptable active site in CYP164 family P450 enzymes, the sole P450 in Mycobacterium leprae.
Influence of Genetic Ancestry on INDEL Markers of NFK?1, CASP8, PAR1, IL4 and CYP19A1 Genes in Leprosy Patients.
Metabolism and interactions of antileprosy drugs.
Metabolism of thalidomide in human microsomes, cloned human cytochrome P-450 isozymes, and Hansen's disease patients.
Polymorphisms in the CYP2E1 and GSTM1 genes as possible protection factors for leprosy patients.
Leukemia
A novel role of CYP2E1 in human megakaryocyte development.
Active repression by unliganded retinoid receptors in development: less is sometimes more.
all-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia.
Aryl hydrocarbon hydroxylase inducibility among primary relatives of children with leukemia or solid tumors.
Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-analyses including 2164 cases and 4160 controls.
Association between CYP2B6 polymorphism and acute leukemia in a Han population of Northwest China.
Association of CYP2B6 G15631T polymorphism with acute leukemia susceptibility.
Association of CYP3A5*3 and CYP1A1*2C Polymorphism with Development of Acute Myeloid Leukemia in Egyptian Patients
Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia.
Chemoprotective Effect of Daphnetin Against Benzene-induced Leukemia via Alteration of CYP2E1.
Comparison of cytochrome P450- and peroxidase-dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites.
CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility.
Cytochrome P-450 family 1 in rat embryo cell culture immortalized by Rausher leukemia virus.
Cytochrome P450 1A1 polymorphism and childhood leukemia: an analysis of matched pairs case-control genotype data.
Cytochrome P450 1B1 promotes cancer cell survival via specificity protein 1 (Sp1)-mediated suppression of death receptor 4.
Detection of CYP2E1, a genetic biomarker of susceptibility to benzene metabolism toxicity in immortal human lymphocytes derived from the Han Chinese Population.
Effects of cytochrome P450 family 3 subfamily A member 5 gene polymorphisms on daunorubicin metabolism and adverse reactions in patients with acute leukemia.
Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures.
Genetic polymorphisms of CYP1A1 and risk of leukemia: a meta-analysis.
Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility.
Genetic predisposition and treatment-related leukemia.
Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers.
Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia.
GSTT1 and CYP2E1 polymorphisms and trihalomethanes in drinking water: effect on childhood leukemia.
Homologs of Drosophila Fushi-Tarazu factor 1 map to mouse chromosome 2 and human chromosome 9q33.
Identification and characterization of a phenyl-thiazolyl-benzoic acid derivative as a novel RAR/RXR agonist.
Immunostimulation by OX40 Ligand Transgenic Ewing Sarcoma Cells.
Lymphocyte aromatic hydrocarbon responsiveness in acute leukemia of childhood.
Meta-analysis of cytochrome P4501A1 MspI gene polymorphism and childhood acute leukemia.
No association between cytochrome P450 2D6 gene polymorphism and risk of acute leukemia: evidence based on a meta-analysis.
Novel insights into etiologies of leukemia: a HuGE review and meta-analysis of CYP1A1 polymorphisms and leukemia risk.
Parental smoking, CYP1A1 genetic polymorphisms and childhood leukemia (Québec, Canada).
Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk.
Pedigree analysis of aryl hydrocarbon hydroxylase inducibility in acute leukemia of childhood.
Polymorphisms in CYP1B1, CYP3A5, GSTT1, and SULT1A1 Are Associated with Early Age Acute Leukemia.
Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment.
Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells.
Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias.
Role of cytochromes P450 in drug metabolism and hepatotoxicity.
The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignancies.
The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia.
The significant role of redox system in myeloid leukemia: from pathogenesis to therapeutic applications.
Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms.
[Expression of CYP3A5 mRNA in children with acute leukemia]
[Polymorphisms of CYP3A5 Gene in Acute Leukemia Patients and Their Role in Chemotherapy and Prognosis.]
[Preliminary study on polymorphism of GSTM1, CYP2E1 and NQO1 genes and risk factors of children leukemia]
[Relation of GSTP1 and CTP2E1 Polymorphisms with Susceptibility to Acute Leukemia.]
[Relationship between the CYP3A5 genetic polymorphism and susceptibility to and prognosis of childhood acute leukemia]
[Study of CYP3A5 in drug resistance mechanisms in acute leukemia]
[Study on the relationship between polymorphisms of Cyp1A1, GSTM1, GSTT1 genes and the susceptibility to acute leukemia in the general population of Hunan province]
[The relationship between cytochrome P450, subfamily IIIA, polypeptide 5 gene and drug resistance in leukemia cell lines]
[Transfection of HL-60 cells with CYP3A5 gene induces drug-resistant phenotype]
Leukemia, Lymphocytic, Chronic, B-Cell
Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.
Dose adjustment of venetoclax when co-administered with posaconazole: clinical drug-drug interaction predictions using a PBPK approach.
Effect of Azithromycin on Venetoclax Pharmacokinetics in Healthy Volunteers: Implications for Dosing Venetoclax with P-gp Inhibitors.
Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival.
Pharmacovigilance during ibrutinib therapy for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) in routine clinical practice.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Association of Genetic Polymorphisms in the Influx Transporter SLCO1B3 and the Efflux Transporter ABCB1 With Imatinib Pharmacokinetics in Patients With Chronic Myeloid Leukemia.
Association of The Common CYP1A1*2C Variant (Ile462Val Polymorphism) with Chronic Myeloid Leukemia (CML) in Patients Undergoing Imatinib Therapy.
Biliary excretion of imatinib mesylate and its metabolite CGP 74588 in humans.
CYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia.
Cytochrome P450 2C19 gene polymorphisms (CYP2C19*2 and CYP2C19*3) in chronic myeloid leukemia patients: in vitro and in silico studies.
Disposition of imatinib and its metabolite CGP74588 in a patient with chronic myelogenous leukemia and short-bowel syndrome.
Do polymorphisms in MDR1 and CYP3A5 genes influence the risk of cytogenetic relapse in patients with chronic myeloid leukemia on imatinib therapy?
Functional polymorphism of CYP2B6 G15631T is associated with hematologic and cytogenetic response in chronic myeloid leukemia patients treated with imatinib.
Genetic polymorphism of CYP3A5 in Indian chronic myeloid leukemia patients.
Genetic polymorphisms of CYP1A1 and risk of leukemia: a meta-analysis.
Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility.
Impact of SLC22A1 and CYP3A5 genotypes on imatinib response in chronic myeloid leukemia: A systematic review and meta-analysis.
In Vivo Cytochrome P450 3A Isoenzyme Activity and Pharmacokinetics of Imatinib in Relation to Therapeutic Outcome in Patients With Chronic Myeloid Leukemia.
Influence of CYP1A1, GST polymorphisms and susceptibility risk of chronic myeloid leukemia in Syrian population.
Influence of CYP2C8 polymorphisms on imatinib steady-state trough level in chronic myeloid leukemia and gastrointestinal stromal tumor patients.
Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia.
Influence of enzyme and transporter polymorphisms on trough imatinib concentration and clinical response in chronic myeloid leukemia patients.
Influence of MDR1 and CYP3A5 genetic polymorphisms on trough levels and therapeutic response of imatinib in newly diagnosed patients with chronic myeloid leukemia.
MDR1 and cytochrome P450 gene-expression profiles as markers of chemosensitivity in human chronic myelogenous leukemia cells treated with cisplatin and Ru(III) metallocomplexes.
Polymorphism analysis of CYP3A5 in myeloid leukemia.
Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population.
SLC22A1-ABCB1 haplotype profiles predict imatinib pharmacokinetics in Asian patients with chronic myeloid leukemia.
[Cytochrome P4501A1, glutathione S-transferase M1 and T1 gene polymorphisms in chronic myeloid leukemia].
[Effect of MDR1 and CYP3A5 gene polymorphisms on outcomes of patients receiving imatinib treatment for chronic myeloid leukemia].
[Relation between single Nucleotide Polymorphisms of CYP3A5 Gene and MDR1 Gene Loci and Risk of CML Cytogenetic Relapse].
Leukemia, Myeloid
Antifungal prophylaxis and novel drugs in acute myeloid leukemia: the midostaurin and posaconazole dilemma.
Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines.
Polymorphism analysis of CYP3A5 in myeloid leukemia.
Leukemia, Myeloid, Acute
A novel role of CYP2E1 in human megakaryocyte development.
All-Trans Retinoic Acid Activity in Acute Myeloid Leukemia: Role of Cytochrome P450 Enzyme Expression by the Microenvironment.
APC2 and CYP1B1 methylation changes in the bone marrow of acute myeloid leukemia patients during chemotherapy.
Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies.
Association of cytochrome P450, glutathione S-transferase and N-acetyl transferase 2 gene polymorphisms with incidence of acute myeloid leukemia.
Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia.
CYP1A1 MspI polymorphism and acute myeloid leukemia risk: meta-analyses based on 5018 subjects.
CYP1A1 polymorphisms modify overall survival in acute myeloid leukemia patients.
Dose adjustment of venetoclax when co-administered with posaconazole: clinical drug-drug interaction predictions using a PBPK approach.
Genetic polymorphisms of CYP1A1 and risk of leukemia: a meta-analysis.
Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility.
Management of Venetoclax-Posaconazole Interaction in Acute Myeloid Leukemia Patients: Evaluation of Dose Adjustments.
Over-expression of CYP2E1 mRNA and protein: implications of xenobiotic induced damage in patients with de novo acute myeloid leukemia with inv(16)(p13.1q22); CBF?-MYH11.
Polymorphism analysis of CYP3A5 in myeloid leukemia.
Polymorphisms and haplotypes of the CYP2B6 detoxification gene in the predisposition of Acute Myeloid Leukemia (AML) and induction of its cytogenetic abnormalities.
Polymorphisms of CYP1A1 and glutathione S-transferase and susceptibility to adult acute myeloid leukemia.
Prognostic Value of a CYP2B6 Gene Polymorphism in Patients with Acute Myeloid Leukemia.
The G?¹?T CYP2B6 germline polymorphism affects the risk of acute myeloid leukemia and is associated with specific chromosomal abnormalities.
Venetoclax plus cytochrome P450 inhibitors without ramp-up strategy led to low risk of tumor lysis syndrome in acute myeloid leukemia.
[Study on the relationship between polymorphisms of Cyp1A1, GSTM1, GSTT1 genes and the susceptibility to acute leukemia in the general population of Hunan province]
Leukemia, Promyelocytic, Acute
Active repression by unliganded retinoid receptors in development: less is sometimes more.
Identification and characterization of a phenyl-thiazolyl-benzoic acid derivative as a novel RAR/RXR agonist.
Leukemia, T-Cell
Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver.
Polymorphic genetic variations of Cytochrome P450 19A1 and T-cell leukemia 1A genes in the Tamil population.
Leukopenia
Antituberculosis Drug-Induced Adverse Events in the Liver, Kidneys, and Blood: Clinical Profiles and Pharmacogenetic Predictors.
Association of vitamin D pathway genes polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population.
Cyclophosphamide treatment-induced leukopenia rates in ANCA-associated vasculitis are influenced by variant CYP450 2C9 genotypes.
Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer.
Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients.
Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity.
Leukoplakia
Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users.
Prevalence of CYP1A1 and GST polymorphisms in the population of northeastern India and susceptibility of oral cancer.
Role of CYP2E1 genetic polymorphism in the development of oral leukoplakia among tobacco users in North Indian population.
Leukoplakia, Oral
Carnosol, a Constituent of Zyflamend, Inhibits Aryl Hydrocarbon Receptor-Mediated Activation of CYP1A1 and CYP1B1 Transcription and Mutagenesis.
Genetic polymorphisms of carcinogen metabolizing enzymes are associated with oral leukoplakia development and p53 overexpression.
Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.
Role of CYP2E1 genetic polymorphism in the development of oral leukoplakia among tobacco users in North Indian population.
Lewy Body Disease
Alternative splicing patterns of CYP2D genes in human brain and neurodegenerative disorders.
CYP2D6 polymorphisms in Alzheimer's disease, with and without extrapyramidal signs, showing no apolipoprotein E epsilon 4 effect modification.
Genetic polymorphism of cytochrome P450 2D6 in idiopathic Parkinson disease and diffuse Lewy body disease.
No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population.
Leydig Cell Tumor
Elevated levels of the Steroidogenic Factor-1 are associated with over-expression of CYP19 in an Estrogen producing testicular Leydig cell tumour.
Primary amenorrhea revealing an occult progesterone-secreting ovarian tumor.
Li-Fraumeni Syndrome
p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling.
Lichen Planus, Oral
Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk.
Cytochrome P450 2D6 polymorphism and drug utilization in patients with oral lichen planus.
Oral lichen planus and intake of drugs metabolized by polymorphic cytochrome P450 enzymes.
Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype.
Lipid Metabolism Disorders
Transcriptome analysis in normal human liver cells exposed to 2, 3, 3', 4, 4', 5 - Hexachlorobiphenyl (PCB 156).
Transcriptome analysis of the effects of chitosan on the hyperlipidemia and oxidative stress in high-fat diet fed mice.
Lipodystrophy
Antiretroviral therapy: are we aware of adverse effects?
Lissencephaly
Genome-wide association analysis of panicle exsertion and uppermost internode in rice (Oryza sativa L.).
Listeriosis
Factors involved in the down-regulation of cytochrome P450 during Listeria monocytogenes infection.
Listeriosis downregulates hepatic cytochrome P450 enzymes in sublethal murine infection.
Liver Abscess, Amebic
Antipyrine clearance, aminopyrine N-demethylase, and bilirubin UDP-glucuronyl transferase activity in patients with amoebic liver abscess.
Liver Cirrhosis
2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: role of inhibition of transforming growth factor-beta1 expression.
A proteomic analysis of thioacetamide-induced hepatotoxicity and cirrhosis in rat livers.
Ascorbic acid supplementation down-regulates the alcohol induced oxidative stress, hepatic stellate cell activation, cytotoxicity and mRNA levels of selected fibrotic genes in guinea pigs.
Beneficial effects of Vitis coignetiae Pulliat leaves on nonalcoholic steatohepatitis in a rat model.
Chemical induced inflammation of the liver breaks tolerance and results in autoimmune hepatitis in Balb/c mice.
Chemical profile of Swertia mussotii Franch and its potential targets against liver fibrosis revealed by cross-platform metabolomics.
Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease.
CYP2A6: a human coumarin 7-hydroxylase.
Cytochrome P450 2D6 polymorphism is a molecular genetic marker of liver cirrhosis progression.
Cytochrome p450 dysregulations in thioacetamide-induced liver cirrhosis in rats and the counteracting effects of hepatoprotective agents.
Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis.
Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis.
Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aerodigestive tract cancer in alcoholic caucasians.
Date fruits inhibit hepatocyte apoptosis and modulate the expression of hepatocyte growth factor, cytochrome P450 2E1 and heme oxygenase-1 in carbon tetrachloride-induced liver fibrosis.
Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients.
Detecting serum and urine metabolic profile changes of CCl4-liver fibrosis in rats at 12 weeks based on gas chromatography-mass spectrometry.
Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases.
Differential Effect of Liver Cirrhosis on the Pregnane X Receptor-Mediated Induction of CYP3A1 and 3A2 in the Rat.
Dysregulation of UDP-glucuronosyltransferases in CCl4 induced liver injury rats.
Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers.
Effects of liver fibrosis on verapamil pharmacokinetics in rats.
Effects of zedoary turmeric oil on P450 activities in rats with liver cirrhosis induced by thioacetamide.
Ethanol-inducible cytochrome P4502E1: genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease.
Fatal rhabdomyolysis in a patient with liver cirrhosis after switching from simvastatin to fluvastatin.
Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity.
Genetic Variants of Alcohol Metabolizing Enzymes and Alcohol-Related Liver Cirrhosis Risk.
Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis.
Hepato-protective role of itraconazole mediated cytochrome p450 pathway inhibition in liver fibrosis.
Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody.
Impaired androgen 16 alpha-hydroxylation in hepatic microsomes from carbon tetrachloride-cirrhotic male rats.
Liver dysfunction markedly decreases the inhibition of cytochrome P450 1A2-mediated theophylline metabolism by fluvoxamine.
Long-term administration of tacrolimus and everolimus prevents high cholesterol-high fructose-induced steatosis in C57BL/6J mice by inhibiting de-novo lipogenesis.
Melatonin serum levels and metabolic clearance rate in patients with liver cirrhosis.
Metabolism of the A1 adenosine receptor PET ligand [18F]CPFPX by CYP1A2: implications for bolus/infusion PET studies.
Metabolomics combined with network pharmacology exploration reveals the modulatory properties of Astragali Radix extract in the treatment of liver fibrosis.
Overexpression of P-glycoprotein, MRP2, and CYP3A4 impairs intestinal absorption of octreotide in rats with portal hypertension.
Pharmacokinetic parameters of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, after intravenous and oral administration of chlorzoxazone to liver cirrhotic rats with diabetes mellitus.
Pharmacokinetics of dl-praeruptorin A after single-dose intravenous administration to rats with liver cirrhosis.
Pharmacokinetics of oltipraz in diabetic rats with liver cirrhosis.
Polyamine biosynthesis and monooxygenase enzyme activity in rat liver cirrhosis and regeneration.
Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics.
Reliability of total overnight salivary caffeine assessment (TOSCA) for liver function evaluation in compensated cirrhotic patients.
Role of CYP2D6 polymorphism in predicting liver fibrosis progression rate in Caucasian patients with chronic hepatitis C.
Role of CYP2E1 in the metabolism of ethanol in patients with liver cirrhosis.
Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes.
The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes.
The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes.
Vitamin D serum level is associated with Child-Pugh score and metabolic enzyme imbalances, but not viral load in chronic hepatitis B patients.
[Drug-induced pneumonitis in a patient treated with venlafaxine and propanolol]
[Effect of Fuzheng Huayu recipe on CYP450 isozymes in normal and liver fibrosis rats].
[Obesity and steatohepatitis. Histologic aspects]
[Perspectives of clinical biochemistry in hepatology]
[Study on CYP1A2, CYP2C9/10 and CYP2C19 activities in rats to create liver cirrhosis by using multi-factor complex].
[The influence of genetic polymorphism of CYP2E1 on the development of alcohol liver cirrhosis]
Liver Cirrhosis, Alcoholic
Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.
Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population.
Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis.
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice.
Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases.
Free radical mechanisms in immune reactions associated with alcoholic liver disease.
Genetic Polymorphisms of Genes Coding to Alcohol-Metabolizing Enzymes in Western Mexicans: Association of CYP2E1*c2/CYP2E1*5B Allele with Cirrhosis and Liver Function.
Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis.
Molecular Mechanisms Involved in the Interaction Effects of Alcohol and HCV in Liver Cirrhosis.
Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis.
Polymorphism in glutathione-S-transferases: a risk factor in alcoholic liver cirrhosis.
Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics.
Liver Cirrhosis, Biliary
13C-methacetin breath test correlates with clinical indices of liver disease severity in patients with primary biliary cirrhosis.
Differential alteration of cytochrome P450 isoenzymes in two experimental models of cirrhosis.
Multidrug resistance 1 genotype and disposition of budesonide in early primary biliary cirrhosis.
No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis.
Liver Cirrhosis, Experimental
Pharmacokinetics of dl-praeruptorin A after single-dose intravenous administration to rats with liver cirrhosis.
Pharmacokinetics of oltipraz in diabetic rats with liver cirrhosis.
Liver Diseases
?-Imidazolyl-alkyl derivatives as new preclinical drug candidates for treating non-alcoholic steatohepatitis.
A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma.
A study on the pharmacokinetics of chlorzoxazone in healthy Thai volunteers.
Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P450 2E1-dependent toxicity in HepG2 cells.
Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver.
Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease.
Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis.
Alternative cyclosporine metabolic pathways and toxicity.
Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury.
Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population.
Association of CYP2C9, CYP2A6, ACSM2A, and CPT1A gene polymorphisms with adverse effects of valproic acid in Chinese patients with epilepsy.
Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics.
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Cardiac actions of antihistamines.
Case Report: Ursodeoxycholic acid treatment in Niemann-Pick disease type C; clinical experience in four cases.
Causality assessment in hepatotoxicity by drugs and dietary supplements.
Changes in caffeine, lidocaine and trimethadione metabolism in carbon tetrachloride-intoxicated rats as assessed by a "cocktail" study.
Clinical importance of non-genetic and genetic cytochrome P450 function tests in liver disease.
Comparing the protective effects of three sulfur compounds against acrylonitrile-induced acute toxicity in CYP2E1-induced rats.
Comparison of Circulating, Hepatocyte Specific Messenger RNA and microRNA as Biomarkers for Chronic Hepatitis B and C.
Comparison of the polymorphic regions of the cytochrome P450 CYP2E1 gene of humans and patas and cynomolgus monkeys.
CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer.
CYP1A1 and MT1K are congener specific biomarker genes for liver diseases induced by PCBs.
CYP1A2 is a predictor of HCC recurrence in HCV-related chronic liver disease: A retrospective multicentric validation study.
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model.
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.
CYP2C19 Polymorphisms and Therapeutic Drug Monitoring of Voriconazole: Are We Ready for Clinical Implementation of Pharmacogenomics?
CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
CYP2E1 and Oxidant Stress in Alcoholic and Non-Alcoholic Fatty Liver Disease.
CYP2E1 autoantibodies in liver diseases.
CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload.
CYP3A suppression during diet-induced nonalcoholic fatty liver disease is independent of PXR regulation.
Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice.
Cytochrome P450 1A2 is a hepatic autoantigen in autoimmune polyglandular syndrome type 1.
Cytochrome P450 2A5 Constitutive Expression and Induction by Heavy Metals Is Dependent on Redox-Sensitive Transcription Factor Nrf2 in Liver.
Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects.
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Cytochrome P450 2E1: its clinical and toxicological role.
Cytochrome P450 and liver diseases.
Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications.
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis.
Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress.
Cytochrome P4502E1 (CYP2E1) expression in peripheral blood lymphocytes: evaluation in hepatitis C and diabetes.
Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases.
Cytochromes P450 and uridine triphosphate-glucuronosyltransferases: model autoantigens to study drug-induced, virus-induced, and autoimmune liver disease.
Defining a relationship between dietary fatty acids and the cytochrome P450 system in a mouse model of fatty liver disease.
Delphi Consensus Recommendations on Management of Dosing, Adverse Events, and Comorbidities in the Treatment of Idiopathic Pulmonary Fibrosis with Nintedanib.
Depression of peripheral blood monocyte aryl hydrocarbon hydroxylase activity in patients with liver disease: possible involvement of macrophage factors.
Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans.
Diet-induced non-alcoholic fatty liver disease affects expression of major cytochrome P450 genes in a mouse model.
Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection.
Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases.
Differential alteration of cytochrome P450 isoenzymes in two experimental models of cirrhosis.
Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease.
Differential Effect of Liver Cirrhosis on the Pregnane X Receptor-Mediated Induction of CYP3A1 and 3A2 in the Rat.
Dihydropyrimidine dehydrogenase activity and fluorouracil pharmacokinetics with liver damage induced by bile duct ligation in rats.
Donor graft does not affect the P450 2C19 genotype expressed in peripheral blood in recipients of living donor liver transplantation.
Drug metabolism and ageing.
Drug metabolism in liver disease: activity of hepatic microsomal metabolizing enzymes.
Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase.
Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function.
Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism.
Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model.
Enzyme inhibition and induction in liver disease.
Establishing population distribution of drug-metabolizing enzyme activities for the use of salivary caffeine as a dynamic liver function marker in a Singaporean Chinese population.
Establishment of an ex Vivo Model of Nonalcoholic Fatty Liver Disease Using a Tissue-Engineered Liver.
Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes.
Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation.
Expression of Cytochrome P450 2A5 in a C57BL/6J Mouse Model of Nonalcoholic Fatty Liver Disease.
Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1.
Expression of P450 and nuclear receptors in normal and end-stage Chinese livers.
Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1.
Gender differences in diet-induced steatotic disease in Cyp2b-null mice.
Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease.
Genetic polymorphism of human CYP2E1: characterization of two variant alleles.
Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.
Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: Association with hepatitis B related advanced liver disease and cancer.
Genetic Polymorphisms of Cytochrome P4501A1 (CYP1A1) and Glutathione S-Transferase P1 (GSTP1) and Risk of Hepatocellular Carcinoma Among Chronic Hepatitis C Patients in Egypt.
Genetic polymorphisms of the hepatic pathways of fatty liver disease after living donor liver transplantation.
Hepatic cytochrome P450 2E1 activity in nonalcoholic fatty liver disease.
Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.
Hepatitis C virus infection associated with liver-kidney microsomal antibody type 1 (LKM1) autoantibodies in children.
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.
Hepatoprotective Effect of Seed Coat ofEuryale ferox Extract in Non-alcoholic Fatty Liver Disease Induced by High-fat Diet in Mice by Increasing IRs-1 and Inhibiting CYP2E1.
High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model.
Higher chlorzoxazone clearance in obese children compared with nonobese peers.
Highly active antiretroviral therapy-induced liver injury.
Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis.
Identification of cytochrome P450IA2 as a human autoantigen.
Identification of human cytochrome P450s as autoantigens.
Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine.
Impaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver disease.
Importance of genetic polymorphisms in liver transplantation outcomes.
In vitro cytochrome p450 activity decreases in children with high pediatric end-stage liver disease scores.
In vivo metabolic activity of CYP2C19 and CYP3A in relation to CYP2C19 genetic polymorphism in chronic liver disease.
Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-alpha.
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role.
Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1.
Independent patterns of cytochrome P450 gene expression in liver and blood in patients with suspected liver disease.
Induction of CYP2E1 in non-alcoholic fatty liver diseases.
Induction of cytochrome P450 enzymes and generation of protein-aldehyde adducts are associated with sex-dependent sensitivity to alcohol-induced liver disease in micropigs.
Inflammation-induced phenoconversion of polymorphic drug metabolizing enzymes: hypothesis with implications for personalized medicine.
Influence of chronic hepatitis C infection on cytochrome P450 3a4 activity using midazolam as an in vivo probe substrate.
Influence of clinicopathological variables on CYP protein expression in human liver.
Influence of liver disease and environmental factors on hepatic monooxygenase activity in vitro.
Influence of rifampin on serum markers of cholesterol and bile acid synthesis in men.
Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers.
Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population.
Interaction of heterogeneous nuclear ribonucleoprotein A1 with cytochrome P450 2A6 mRNA: implications for post-transcriptional regulation of the CYP2A6 gene.
Interleukin-1, platelet derived growth factor, free radicals and monocyte aryl hydrocarbon hydroxylase activity in liver disease. Role of cell communication.
Investigation of the genetic markers associated with alcoholic liver diseases.
Laboratory and clinical outcomes of pharmacogenetic vs. clinical protocols for warfarin initiation in orthopedic patients.
Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice.
Liver disease selectively modulates cytochrome P450--mediated metabolism.
Liver dysfunction markedly decreases the inhibition of cytochrome P450 1A2-mediated theophylline metabolism by fluvoxamine.
Liver-enriched transcription factor expression relates to chronic hepatic failure in humans.
Localization of CYP4B1 in the rat nasal cavity and analysis of CYPs as secreted proteins.
Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease.
Mining for Oxysterols in Cyp7b1-/- Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5.
Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors.
Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis.
Monocyte aryl hydrocarbon hydroxylase (AHH) activity mimics Kupffer cell and hepatocyte AHH activity in an animal model of liver disease.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Nanoformulated SOD1 ameliorates the combined NASH and alcohol-associated liver disease partly via regulating CYP2E1 expression in adipose tissue and liver.
Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model.
Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Cytochrome P450 (CYP) Enzymes.
Normal-release and controlled-release oxycodone: pharmacokinetics, pharmacodynamics, and controversy.
Optimizing combination of liver-enriched transcription factors and nuclear receptors simultaneously favors ammonia and drug metabolism in liver cells.
Overexpression of CYP2E1 in Mitochondria Sensitizes HepG2 Cells to the Toxicity Caused by Depletion of Glutathione.
Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease.
P450 enzymes. Inhibition mechanisms, genetic regulation and effects of liver disease.
Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450 db1 that is inhibited by LKM-1 autoantibodies in vitro but not in vivo.
Pharmacokinetic assessment of nevirapine and metabolites in human immunodeficiency virus type 1-infected patients with hepatic fibrosis.
Pharmacological Mechanisms Underlying the Hepatoprotective Effects of Ecliptae herba on Hepatocellular Carcinoma.
Population Pharmacokinetic/Pharmacodynamic Analyses of Avatrombopag in Patients With Chronic Liver Disease and Optimal Dose Adjustment Guide With Concomitantly Administered CYP3A and CYP2C9 Inhibitors.
Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein.
Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis.
Proceedings: The relation between cytochrome P450 in liver biopsies and drug metabolism in patients with liver disease and in morphine addiction.
Quantitation of cytochrome P450 mRNAs in patients with suspected liver diseases as assessed by reverse transcriptase-polymerase chain reaction.
Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism.
Regulation of the cytochrome P450 epoxyeicosanoid pathway is associated with distinct histologic features in pediatric non-alcoholic fatty liver disease.
Relationship between antipyrine metabolism and acetylation phenotype in health and chronic liver diseases.
Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients.
Relevance of CYP2E1 to Non-alcoholic Fatty Liver Disease.
Reliability of total overnight salivary caffeine assessment (TOSCA) for liver function evaluation in compensated cirrhotic patients.
Role of CYP2E1 gene polymorphisms association with hepatitis risk in Northeast India.
Role of iron in alcoholic liver disease: introduction and summary of the symposium.
RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma.
Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6.
Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes.
Severe Neonatal Cholestasis in Cerebrotendinous Xanthomatosis: Genetics, Immunostaining, Mass Spectrometry.
Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin.
Sorafenib-induced liver failure: a case report and review of the literature.
Susceptibility to thyroid disorders in hepatitis C.
TA allele of rs2070673 in the CYP2E1 gene is associated with lobular inflammation and nonalcoholic steatohepatitis in patients with biopsy-proven nonalcoholic fatty liver disease.
Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice.
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice.
The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease.
The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.
The effect of liver disease on urine caffeine metabolite ratios.
The RsaI polymorphism of CYP2E1 and susceptibility to alcoholic liver disease in Caucasians: effect on age of presentation and dependence on alcohol dehydrogenase genotype.
Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition.
Toxicogenomics directory of chemically exposed human hepatocytes.
Transcriptional Repression of CYP3A4 by Increased miR-200a-3p and miR-150-5p Promotes Steatosis in vitro.
Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease.
Two cytochromes P450 are major hepatocellular autoantigens in autoimmune polyglandular syndrome type 1.
UDP-glucuronosyltransferase in the regenerating rat liver.
Variability of caffeine metabolism in humans.
Vitamin D serum level is associated with Child-Pugh score and metabolic enzyme imbalances, but not viral load in chronic hepatitis B patients.
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models.
[Cisapride and risk of cardiac complications]
[Influence of electroacupuncture on hepatic cytochrome P450 1 A 1 expression and lipid peroxidation in nonalcoholic fatty liver rats]
[The eye as target of adverse ocular drug reactions. Focus on systemic antiinfective therapy].
[The genotype of CYP2E1 and liver-derived serum enzymes]
[The role of cytochrome P450 in nonalcoholic fatty liver induced by high-fat diet: a gene expression profile analysis].
Liver Diseases, Alcoholic
Alcohol and the liver.
Alcoholic liver disease: from CYP2E1 to CYP2A5.
Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9.
Clomethiazole inhibits cytochrome P450 2E1 and improves alcoholic liver disease.
CYP2E1 activity in patients with alcoholic liver disease.
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
CYP2E1 expression in human lymphocytes from various ethnic populations.
CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload.
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice.
Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress.
Cytochrome P450 and liver diseases.
Cytochrome P4502E1 inducibility and hydroxyethyl radical formation among alcoholics.
Cytochrome P4502E1 primes macrophages to increase TNF-alpha production in response to lipopolysaccharide.
Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases.
Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1.
Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase.
Effect of ALDH2 and CYP2E1 gene polymorphisms on drinking behavior and alcoholic liver disease in Japanese male workers.
Effects of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 (CYP2E1) in the liver of rats chronically fed ethanol.
Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5.
Estrogen-related receptor ? controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol.
Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2.
Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease.
Genetic polymorphism of cytochrome P450. Functional consequences and possible relationship to disease and alcohol toxicity.
Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics.
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis.
Human lymphocyte cytochrome P450 2E1, a putative marker for alcohol-mediated changes in hepatic chlorzoxazone activity.
Influence of royal jelly on mouse hepatic gene expression and safety assessment with a DNA microarray.
Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole.
Intragastric ethanol infusion model for cellular and molecular studies of alcoholic liver disease.
Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats.
Mutations in the exons and exon-intron junction regions of human cytochrome P-4502E1 gene and alcoholism.
Mutations in the Exons and Exon-Intron Junction Regions of Human Cytochrome P-4502E1 Gene and Alcoholism.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Polymorphism in the cytochrome P450 2E1 gene and the risk of alcoholic liver disease.
Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage.
Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling.
Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system.
Role of CYP2E1 in the pathogenesis of alcoholic liver disease: modifications by cAMP and ubiquitin-proteasome pathway.
Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity.
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
Role of iron in alcoholic liver disease: introduction and summary of the symposium.
ROR? switches transcriptional mode of ERR? that results in transcriptional repression of CYP2E1 under ethanol-exposure.
SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease.
Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells.
The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice.
The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.
The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model.
The Importance of CYP2E1 in the Pathogenesis of Alcoholic Liver Disease and Drug Toxicity and the Role of the Proteasome.
The RsaI polymorphism of CYP2E1 and susceptibility to alcoholic liver disease in Caucasians: effect on age of presentation and dependence on alcohol dehydrogenase genotype.
Use of dietary saturated fatty acids and vitamin E in the treatment of alcoholic liver disease.
Use of molecular simulation for mapping conformational CYP2E1 epitopes.
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models.
[Oxidative stress and liver disease]
[Relationship among hepatocyte apoptosis, P450 2E1 and oxidative stress in alcoholic liver disease of rats]
Liver Failure
Alginate-encapsulated human hepatoblastoma cells in an extracorporeal perfusion system improve some systemic parameters of liver failure in a xenogeneic model.
Decellularized Liver Matrix-Modified Cryogel Scaffolds as Potential Hepatocyte Carriers in Bioartificial Liver Support Systems and Implantable Liver Constructs.
Hepatic Failure From Pennyroyal Tea Interaction With Medications Metabolized by the Cytochrome P450 Enzymes.
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
IgG3 is the dominant subtype of anti-isoniazid antibodies in patients with isoniazid-induced liver failure.
Involvement of cytochrome P450 in cisplatin treatment: implications for toxicity.
Mechanism of isoniazid-induced hepatotoxicity: then and now.
Promising new approaches.
Tolterodine: a new antimuscarinic agent for the treatment of the overactive bladder.
Liver Failure, Acute
A non-hepatotropic parasite infection increases mortality in the acetaminophen-induced acute liver failure murine model: possible roles for IL-5 and IL-6.
Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1.
Alginate-encapsulated human hepatoblastoma cells in an extracorporeal perfusion system improve some systemic parameters of liver failure in a xenogeneic model.
Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure.
Melatonin protects against apoptosis-inducing factor (AIF)-dependent cell death during acetaminophen-induced acute liver failure.
Myristica fragrans Kernels Prevent Paracetamol-Induced Hepatotoxicity by Inducing Anti-Apoptotic Genes and Nrf2/HO-1 Pathway.
Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 expression.
Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats.
Sanghuangporus sanghuang Mycelium Prevents Paracetamol-Induced Hepatotoxicity through Regulating the MAPK/NF-?B, Keap1/Nrf2/HO-1, TLR4/PI3K/Akt, and CaMKK?/LKB1/AMPK Pathways and Suppressing Oxidative Stress and Inflammation.
Liver Neoplasms
Bioinformatic analysis reveals CYP2C9 as a potential prognostic marker for HCC and liver cancer cell lines suitable for its mechanism study.
Cellular Metabolism in High-Throughput In Vitro Reporter Gene Assays and Implications for the Quantitative In Vitro-In Vivo Extrapolation.
CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures.
CYP2A6 gene polymorphism and risk of liver cancer and cirrhosis.
CYP2C8 regulated by GAS5/miR-382-3p exerts anti-cancerous properties in liver cancer.
CYP2D6 genes and risk of liver cancer.
CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload.
CYP2E1 RsaI/PstI polymorphism and liver cancer risk among east Asians: a HuGE review and meta-analysis.
Cytochrome P450 1A2 Metabolizes 17?-Estradiol to Suppress Hepatocellular Carcinoma.
Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4.
Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism.
Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients.
Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes.
Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia.
Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody.
In vitro metabolism of aflatoxin B1 by normal and tumorous liver tissue from Thailand.
Increased effects of 2,5-dimethylcelecoxib on sensitivity of hepatocellular carcinoma cells to sorafenib via CYP3A5 expression and activation of AMPK.
Individuals having variant genotypes of cytochrome P450 2C19 are at increased risk of developing primary liver cancer in Han populations, without infection with the hepatitis virus.
Inhibition of calcitriol inactivating enzyme CYP24A1 gene expression by flavonoids in hepatocellular carcinoma cells under normoxia and hypoxia.
Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer.
Meta-analysis of CYP2E1 polymorphisms in liver carcinogenesis.
Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma.
N-Hydroxylation of 4-Aminobiphenyl by CYP2E1 Produces Oxidative Stress in a Mouse Model of Chemically Induced Liver Cancer.
Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway.
P450-based porous silicon biosensor for arachidonic acid detection.
Pharmacological blockage of CYP2E1 and alcohol-mediated liver cancer: is the time ready?
Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein.
Role of iron in alcoholic liver disease: introduction and summary of the symposium.
STAT3 & Cytochrome P450 2C9: a novel signaling pathway in liver cancer stem cells.
Sulfated extract of Abelmoschus esculentus: A potential cancer chemopreventive agent.
The effect of serum from liver cancer patients on the growth and function of primary and immortalised hepatocytes.
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
The regulation mechanism of AhR activated by benzo[a]pyrene for CYP expression are different between 2D and 3D culture of human lung cancer cells.
The ubiquitin-proteasome 26s pathway in liver cell protein turnover: effect of ethanol and drugs.
Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.
[Inhibitory effect of ellipticine (dimethyl-5,11-(6H) pyrido (4,3-b) carbazole on the induction of liver cancer by BT6 (N,N-dimethyl-p-(benzothiazolylazo) analine) and its effect on the levels of cytochrome P450 and arginase activity]
[Liver Tissue-specific Genes IGFALS,CYP3A4,SLC22A1 and CYP2E1 May be Associated with Poor Prognosis of Liver Cancer].
Liver Neoplasms, Experimental
Axyl hydrocarbon hydroxylase in Morris hepatoma 5123D.
Microsomal monooxygenase system in Morris hepatoma: purification and characterization of cytochromes P-450 from Morris hepatoma 5123D of 3-methylcholanthrene-treated rats.
Properties of aryl hydrocarbon hydroxylase in microsomes of Morris hepatoma 5123D and the host liver.
Long QT Syndrome
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Pharmacogenetic issues in thorough QT trials.
Sex differences in arrhythmias.
[Cisapride and risk of cardiac complications]
Low Tension Glaucoma
Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis.
Lung Diseases
Analyses of bronchial bulky DNA adduct levels and CYP2C9, GSTP1 and NQO1 genotypes in a Hungarian study population with pulmonary diseases.
Caffeine intake reduces incident atrial fibrillation at a population level.
Comparison of pulmonary DNA adduct levels, measured by 32P-postlabelling and aryl hydrocarbon hydroxylase activity in lung parenchyma of smokers and ex-smokers.
CYP1B1 genotype and risk of cardiovascular disease, pulmonary disease, and cancer in 50,000 individuals.
Decreased Cyp2E1 mRNA expression in human leucocytes in patients with fibrotic and inflammatory lung diseases.
Differential effects of the particle core and organic extract of diesel exhaust particles.
Hyperoxia-induced changes in estradiol metabolism in postnatal airway smooth muscle.
Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population.
Polymorphism in CYP1A1 and CYP2D6 genes: possible association with susceptibility to lung cancer.
The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population.
[Applications of aryl hydrocarbon hydroxylase in diagnosis of lung cancer]
[Study on the association between genetic polymorphism of CYP2E1, GSTM1 and susceptibility of lung cancer.]
Lung Diseases, Interstitial
Cytochrome P450 polymorphisms and drug-induced interstitial lung disease.
Exacerbation of benzene pneumotoxicity in connexin 32 knockout mice: enhanced proliferation of CYP2E1-immunoreactive alveolar epithelial cells.
Gefitinib: new preparation. Non small-cell lung cancer: stricter assessment needed.
Relationship between drug-induced interstitial lung diseases and cytochrome P450 polymorphisms.
Lung Diseases, Obstructive
Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.
[The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disease patients]
Lung Injury
?-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice.
Apoptosis and Bax expression are increased by coal dust in the polycyclic aromatic hydrocarbon-exposed lung.
Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB.
Attenuation of hyperoxic lung injury by the CYP1A inducer beta-naphthoflavone.
Attenuation of oxygen-induced abnormal lung maturation in rats by retinoic acid: possible role of cytochrome P4501A enzymes.
Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo.
Cimetidine does not prevent lung injury in newborn premature infants.
Comparison of the arachidonic acid and NADPH-dependent microsomal metabolism of naphthalene and 2-methylnaphthalene and the effect of indomethacin on the bronchiolar necrosis.
Cytochrome P450 polymorphisms and drug-induced interstitial lung disease.
Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury.
Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury.
Effects of Real-Ambient PM2.5 Exposure on Lung Damage Modulated by Nrf2-/.
Ethanol metabolism, oxidative stress, and endoplasmic reticulum stress responses in the lungs of hepatic alcohol dehydrogenase deficient deer mice after chronic ethanol feeding.
Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice.
Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children.
High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4.
Hyperoxia-mediated transcriptional activation of cytochrome P4501A1 (CYP1A1) and decreased susceptibility to oxygen-mediated lung injury in newborn mice.
Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene.
Inhaled nitric oxide attenuates hyperoxic lung injury in lambs.
Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-?B activation.
Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites.
Lung vascular injury from monocrotaline pyrrole, a putative hepatic metabolite.
Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury.
Mice Deficient in the Gene for Cytochrome P450 (CYP)1A1 Are More Susceptible Than Wild-Type to Hyperoxic Lung Injury: Evidence for Protective Role of CYP1A1 Against Oxidative Stress.
Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type.
Modulation of Pulmonary Cytochrome P4501A1 Expression by Hyperoxia and Inhaled Nitric Oxide in the Newborn Rat: Implications for Lung Injury.
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
Newborn mice lacking the gene for Cyp1a1 are more susceptible to oxygen-mediated lung injury, and are rescued by postnatal ?-napthoflavone (BNF) administration: Implications for bronchopulmonary dysplasia (BPD) in premature infants.
Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor.
Omeprazole Attenuates Hyperoxic Lung Injury in Mice via Aryl hydrocarbon Receptor Activation, and is Associated with Increased Expression of Cytochrome P4501A Enzymes.
Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects.
Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole.
Prenatal administration of the cytochrome P4501A inducer, ?-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: Implications for bronchopulmonary dysplasia (BPD) in premature infants.
Proton-pump inhibitor omeprazole attenuates hyperoxia induced lung injury.
Pulmonary activation and toxicity of cyclopentadienyl manganese tricarbonyl.
Pulmonary toxicity and metabolic activation of tetrandrine in CD-1 mice.
Regulation of cytochrome P4501A1 expression by hyperoxia in human lung cell lines: Implications for hyperoxic lung injury.
Regulation of pulmonary and hepatic cytochrome P4501A expression in the rat by hyperoxia: implications for hyperoxic lung injury.
Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome.
Sex-specific differences in hyperoxic lung injury in mice: Role of cytochrome P450 (CYP)1A.
Sheep lung cytochrome P4501A1 (CYP1A1): cDNA cloning and transcriptional regulation by oxygen tension.
The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury.
Toxic Acetaminophen Exposure Induces Distal Lung ER Stress, Proinflammatory Signaling, and Emphysematous Changes in the Adult Murine Lung.
[The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disease patients]
Lung Neoplasms
11Beta-hydroxysteroid dehydrogenase 1 expression in squamous cell carcinomas of the head and neck.
A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.
A case-control study of cytochrome P450 1A1, glutathione S-transferase M1, cigarette smoking and lung cancer susceptibility (Massachusetts, United States)
A novel duplication type of CYP2A6 gene in African-American population.
A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population.
A possible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cells and tumor tissues.
A race-specific genetic polymorphism in the CYP1A1 gene is not associated with lung cancer in African Americans.
A regulatory variant in CYP2E1 affects the risk of lung squamous cell carcinoma.
A specific African-American CYP1A1 polymorphism is associated with adenocarcinoma of the lung.
Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.
Altered regulation of the cytochrome P4501A1 gene: novel inducer-independent gene expression in pulmonary carcinoma cell lines.
An Rsa I polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population.
Analysis of CYP1A1 exon 7 polymorphisms by PCR-SSCP in a Brazilian population and description of two novel gene variations.
Analysis of CYP2D6 expression in human lung: implications for the association between CYP2D6 activity and susceptibility to lung cancer.
Analysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer.
Antioxidant and antitumor efficacy of Luteolin, a dietary flavone on benzo(a)pyrene-induced experimental lung carcinogenesis.
Antiproliferative and antioxidant potential of beta-ionone against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
Application of molecular epidemiology to lung cancer chemoprevention.
Aryl hydrocarbon hydroxylase activity in human lung tissue: in relation to cigarette smoking and lung cancer.
Aryl hydrocarbon hydroxylase activity in pulmonary alveolar macrophages and lymphocytes from lung cancer and noncancer patients: a correlation with family histories of cancer.
Aryl hydrocarbon hydroxylase activity in pulmonary macrophages and blood lymphocytes. Asbestos-exposed cigarette smokers with and without lung cancer.
Aryl hydrocarbon hydroxylase activity in pulmonary macrophages and lymphocytes from lung cancer and noncancer patients.
Aryl hydrocarbon hydroxylase in human bronchial epithelium and blood monocyte.
Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls.
Aryl hydrocarbon hydroxylase in man and lung cancer.
Aryl hydrocarbon hydroxylase inducibility and lymphoblast formation in lung cancer patients.
Aryl hydrocarbon hydroxylase inducibility in lung cancer patients undergoing radiotherapy.
Assessment of cancer susceptibility in humans by use of genetic polymorphisms in carcinogen metabolism.
Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population.
Association between a cytochrome P450 CYPIA1 genotype and incidence of lung cancer.
Association between Cancer Risk and Drug Metabolizing Enzyme Gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) Polymorphisms in Japanese Cases of Lung Cancer.
Association between CYP2A13 polymorphisms and lung cancer: A protocol for systematic review and meta-analysis.
Association between CYP2A6 genetic polymorphisms and lung cancer: a meta-analysis of case-control studies.
Association between CYP2E1 genetic polymorphisms and lung cancer risk: a meta-analysis.
Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer.
Association between lung cancer and microsomal epoxide hydrolase genotypes.
Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms.
Association Between Polymorphisms in COMT, PLCH1, and CYP17A1, and Non-Small-Cell Lung Cancer Risk in Chinese Nonsmokers.
Association between the combined effects of GSTM1 present/null and CYP1A1 MspI polymorphisms with lung cancer risk: an updated meta-analysis.
Association between the CYP1A1 gene polymorphism and susceptibility to emphysema and lung cancer.
Association Between the CYP1B1 Polymorphisms and Lung Cancer Risk: A Meta-Analysis.
Association between the CYP2E1 polymorphisms and lung cancer risk: a meta-analysis.
Association of aryl hydrocarbon receptor and cytochrome P4501B1 expressions in human non-small cell lung cancers.
Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma.
Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer.
Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India.
Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer.
Association of CYP1B1 Leu432Val Polymorphism and Lung Cancer Risk: An Updated Meta-Analysis.
Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study.
Association of CYP2A6*4 with susceptibility of lung cancer: a meta-analysis.
Association of CYP2E1 and NAT2 polymorphisms with lung cancer susceptibility among Mongolian and Han populations in the Inner Mongolian region.
Association of CYP3A4, CYP3A5 polymorphisms with lung cancer risk in Bangladeshi population.
Association of functionally important polymorphisms in cytochrome P4501B1 with lung cancer.
Association of genetic polymorphisms CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 with tobacco-induced lung Cancer: case-control study in an Egyptian population.
Association of Ile462Val (Exon 7) polymorphism of cytochrome P450 IA1 with lung cancer in the Asian population: further evidence from a case-control study in Okinawa.
Association of the G134A and G184C Polymorphisms in the CYP1A1 Gene with Lung Cancer Incidence.
Associations between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking and susceptibility to lung cancer.
Associations of CYP1A1, GSTM1 and GSTT1 Polymorphisms with Lung Cancer Susceptibility in a Northern Indian Population.
Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens.
Associations of CYP1A2 Polymorphisms with the Risk Haplotypes in Lung Cancer in the Slovak Population.
Benzylmorpholine Analogs as Selective Inhibitors of Lung Cytochrome P450 2A13 for the Chemoprevention of Lung Cancer in Tobacco Users.
Biochemistry of nicotine metabolism and its relevance to lung cancer.
Can CYP1A1 siRNA be an effective treatment for lung cancer?
Carcinogen-induced tissue vitamin A depletion. Potential protective advantages of beta-carotene.
Catalytic properties of polymorphic human cytochrome P450 1B1 variants.
Cell type-specific differences in metabolic activation of N-nitrosodiethylamine by human lung cancer cell lines.
Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer.
Characterization of common CYP1B1 variants with different capacity for benzo[a]pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene.
Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers.
Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq.
Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-I and glutathione-metabolizing enzymes in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice.
Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1.
Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study.
Combinations of the Variant Genotypes of CYP1A1, GSTM1 and GSTT1 are Associated with an Increased Lung Cancer Risk in North Indian Population: a Case-Control Study.
Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects.
Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer.
Combined effect of GSTM1, GSTT1 and GSTP1 polymorphisms on histological subtypes of lung cancer.
Combined effects of CYP1A1 MspI and GSTM1 genetic polymorphisms on risk of lung cancer: an updated meta-analysis.
Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility.
Combined effects of serum trace metals and polymorphisms of CYP1A1 or GSTM1 on non-small cell lung cancer: A hospital based case-control study in China.
Combined genetic polymorphism and risk for development of lung cancer.
Comparison of cytochrome P450 2A6 polymorphism frequencies in Caucasians and African-Americans using a new one-step PCR-RFLP genotyping method.
Comparison of pulmonary DNA adduct levels, measured by 32P-postlabelling and aryl hydrocarbon hydroxylase activity in lung parenchyma of smokers and ex-smokers.
Concomitant occurence of multiple autoantibodies against human cytochromes P450.
Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR.
Corneal damage and lacrimal gland dysfunction in a smoking rat model.
Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer.
Correlation between lung cancer prevalence and activities of aryl hydrocarbon hydroxylase and glutathione S-transferase in human lung tissues.
Correlation between P450 CYP1A1 inducibility, MspI genotype and lung cancer incidence.
Correlation of CYP1A1, GSTP1 and GSTM1 gene polymorphisms and lung cancer risk among smokers.
Correlation of inducibility of aryl hydrocarbon hydroxylase with susceptibility to 3-methylcholanthrene-induced lung cancers.
Current evidence on the relationship between CYP1B1 polymorphisms and lung cancer risk: a meta-analysis.
Current evidence on the relationship between three polymorphisms in the CYP1A2 gene and the risk of cancer.
CYP 1A1 polymorphism and risk of lung cancer in relation to tobacco smoking: a case-control study in China.
CYP 450 polymorphisms as risk factors for early onset lung cancer: gender specific differences.
CYP1A1 *2B and *4 polymorphisms are associated with lung cancer susceptibility in Mexican patients.
CYP1A1 and CYP1B1 Polymorphism and Lung Cancer Risk in Relation to Tobacco Smoking.
CYP1A1 and CYP1B1 polymorphisms and risk of lung cancer among never smokers: a population-based study.
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population.
CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil.
CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis.
CYP1A1 and GSTM1 genetic polymorphisms in lung cancer populations exposed to arsenic in drinking water.
CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis.
CYP1A1 and GSTM1 polymorphisms in relation to lung cancer risk in Chinese women.
CYP1A1 exon7 polymorphism is associated with lung cancer risk among the female population and among smokers: a meta-analysis.
CYP1A1 gene polymorphisms and smoking status as modifier factors for lung cancer risk.
CYP1A1 gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study.
CYP1A1 genetic polymorphisms, tobacco smoking and lung cancer risk in a French Caucasian population.
CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin.
CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China.
CYP1A1 I462V polymorphism is associated with reduced genotoxicity in yeast despite positive association with increased cancer risk.
CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis based on 32 studies.
CYP1A1 Ile462Val polymorphism and the risk of non-small cell lung cancer in a Chinese population.
CYP1A1 Ile462Val Polymorphism Contributes to Lung Cancer Susceptibility among Lung Squamous Carcinoma and Smokers: A Meta-Analysis.
CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor.
CYP1A1 m1 and m2 polymorphisms: genetic susceptibility to lung cancer.
CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndromes patients.
CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: an updated meta-analysis and review.
CYP1A1 MspI polymorphism and susceptibility to lung cancer in the Chinese population: an updated meta-analysis and review.
CYP1A1 MspI polymorphisms and lung cancer risk: an updated meta-analysis involving 20,209 subjects.
CYP1A1 polymorphisms and lung cancer risk: a meta-analysis.
CYP1A1 polymorphisms and risk of lung cancer in non-smoking Chinese women: influence of environmental tobacco smoke exposure and GSTM1/T1 genetic variation.
CYP1A1 Polymorphisms and Risk of Lung Cancer in the Ethnic Kashmiri Population.
CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls.
CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African Americans.
CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people.
CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-gene interactions.
CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations.
CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification.
CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population.
CYP1A2 rs2069514 polymorphism and lung cancer susceptibility: a meta-analysis.
CYP1A2 rs762551 polymorphism contributes to risk of lung cancer: A meta-analysis.
CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women.
CYP2A6 deletion polymorphism is associated with decreased susceptibility of lung cancer in Asian smokers: a meta-analysis.
CYP2A6 gene deletion reduces susceptibility to lung cancer.
CYP2A6 genetic polymorphism is associated with decreased susceptibility to squamous cell lung cancer in Japanese smokers.
CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study.
CYP2A6 Genotype and Smoking Behavior in Current Smokers Screened for Lung Cancer.
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
CYP2A6 polymorphism reveals differences in Japan and the existence of a specific variant in Ovambo and Turk populations.
CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers--findings from two independent populations.
CYP2A6, CYP1A1, and CYP2D6 polymorphisms in lung cancer patients from Central South China.
CYP2A6: genetics, structure, regulation, and function.
CYP2D6 gene polymorphism in caucasian smokers: lung cancer susceptibility and phenotype-genotype relationships.
CYP2D6 genotype and lung cancer risk according to histologic type and tobacco exposure.
CYP2D6 genotyping and the association with lung cancer susceptibility.
CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles.
CYP2D6 T188C variant is associated with lung cancer risk in the Chinese population.
CYP2E1 and GSTM1 gene polymorphisms, environmental factors, and the susceptibility to lung cancer.
CYP2E1 polymorphism, cigarette smoking, p53 expression, and survival in non-small cell lung cancer: a long term follow-up study.
CYP2E1 rs2031920, COMT rs4680 Polymorphisms, Cigarette Smoking, Alcohol Use and Lung Cancer Risk in a Japanese Population.
CYP2E1 Rsa ?/Pst ? polymorphism and lung cancer susceptibility: a meta-analysis involving 10,947 subjects.
CYP2E1 Rsa ?/Pst ? polymorphism and lung cancer susceptibility: A meta-analysis involving 10,947 subjects.
CYP2E1 Rsa I/Pst I polymorphism is associated with lung cancer risk among Asians.
CYP3A5*1 is an inhibitory factor for lung cancer in Taiwanese.
CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in Chinese Han population.
Cytochrome P450 1A1 exon 7 polymorphism and susceptibility to lung cancer in the Chinese population: an updated meta-analysis and review.
Cytochrome P450 1A1 MspI polymorphism and urinary 1-hydroxypyrene concentrations in coke-oven workers.
Cytochrome P450 1B1 (CYP1B1) polymorphisms are associated with clinical outcome of docetaxel in non-small cell lung cancer (NSCLC) patients.
Cytochrome P450 2A isoenzymes in freshly prepared blood lymphocytes isolated from rats and validation as a biomarker for clinical studies in humans.
Cytochrome P450 2A6 deletion polymorphism and risk of lung cancer: a meta-analysis.
Cytochrome P450 2A6 whole-gene deletion (CYP2A6*4) polymorphism reduces risk of lung cancer: A meta-analysis.
Cytochrome P450 2E1 DraI polymorphisms in lung cancer in minority populations.
Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.
Cytochrome P450 2E1 RsaI/PstI and DraI Polymorphisms Are Risk Factors for Lung Cancer in Mongolian and Han Population in Inner Mongolia.
Cytochrome P450 ?-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer.
Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.
Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility.
Cytochrome P450 CYP2D6 gene polymorphism and lung cancer susceptibility in Caucasians.
Cytochrome P450 expression (CYP) in non-small cell lung cancer.
Cytochrome P450 in non-small cell lung cancer related to exogenous chemical metabolism.
Cytochrome P450-isoenzyme 1A1 in susceptibility to tobacco-related lung cancer.
Cytochrome P4501A2 (CYP1A2) activity and lung cancer risk: a preliminary study among Chinese women in Singapore.
Cytochrome P4502C9 genotype in Southeast Anatolia and possible relation with some serum tumour markers and cytokines.
Cytochrome P4502E1 genetic polymorphisms and lung cancer in a Taiwanese population.
Cytotoxicity and genotoxicity of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol in CYP1A1-expressing human fibroblasts quantitatively correlate with CYP1A1 expression level.
Debrisoquin oxidation genotype and susceptibility to lung cancer.
Decreased expression of cytochrome p450 1B1 in non-small cell lung cancer.
Detection of CYP1A1 gene polymorphism using designed RFLP and distributions of CYP1A1 genotypes in Japanese.
Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes.
Determinants of Gefitinib toxicity in advanced non-small cell lung cancer (NSCLC): a pharmacogenomic study of metabolic enzymes and transporters.
Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes.
Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility--a review.
Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk.
Differences in Toxicological and Pharmacological Responses Mediated by Polymorphic Cytochromes P450 and Related Drug-Metabolizing Enzymes.
Differential Distribution of CYP2A6 and CYP2A13 in the Human Respiratory Tract.
Direct genotyping of Cytochrome P450 2A6 whole gene deletion from human blood samples by the SmartAmp method.
Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme.
Dissociation between aryl hydrocarbon hydroxylase activity in cultured pulmonary macrophages and blood lymphocytes from lung cancer patients.
DNA adduct level in lung tissue may act as a risk biomarker of lung cancer.
DNA haplotype dependency of debrisoquine 4-hydroxylase (CYP2D6) expression among extensive metabolisers.
DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung.
Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients.
Drug interactions with tobacco smoking. An update.
Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption.
Early changes in gene expression induced by tobacco smoke: Evidence for the importance of estrogen within lung tissue.
Editorial: Aryl hydrocarbon hydroxylase inducibility and lung cancer.
Effect of alcohol and its metabolites in lung cancer: CAPUA study.
Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women.
Effect of CYP1A1 MSPI Polymorphism on the Relationship Between TP53 Mutation and CDKN2A Hypermethylation in Non-small Cell Lung Cancer.
Effect of transforming growth factor-beta1 on expression of aryl hydrocarbon receptor and genes of Ah gene battery: clues for independent down-regulation in A549 cells.
Effects of 8-methoxypsoralen on cytochrome P450 2A13.
Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.
Effects of CYP2D6 activity and tobacco on larynx cancer risk.
Effects of CYP3A5 genetic polymorphism and smoking on the prognosis of non-small-cell lung cancer.
Environmental factors and aryl hydrocarbon hydroxylase activity (CYP1A1 phenotype) in human lymphocytes.
Environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women.
Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma.
Erlotinib treatment induces cytochrome P450 3A activity in non-small cell lung cancer patients.
Estrogen metabolism within the lung and its modulation by tobacco smoke.
Estrogen receptor alpha promotes smoking-carcinogen-induced lung carcinogenesis via cytochrome P450 1B1.
Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol.
Estrongenic steroid hormones in lung cancer.
Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway.
Ethnic susceptibility to lung cancer: differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between French Caucasian and Chilean populations.
Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers.
Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients.
Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis.
Evidence-based prevention (EBP): A review of cytochrome P450 expression in the bronchial epithelium and new approach to lung cancer prevention.
Evidence-based prevention (EBP): approach to lung cancer prevention based on cytochrome 1A1 and cytochrome 2E1 polymorphism.
Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer.
Expression of aromatase CYP19 and its relationship with parameters in NSCLC.
Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.
Expression of cytochrome P450 2A13 in human non-small cell lung cancer and its clinical significance.
Expression of cytochrome P450 in non-small cell lung cancer.
Expression of pulmonary cytochrome P4501A1 and carcinogen DNA adduct formation in high risk subjects for tobacco-related lung cancer.
Finding Genes Discriminating Smokers from Non-smokers by Applying a Growing Self-organizing Clustering Method to Large Airway Epithelium Cell Microarray Data.
Four polymorphisms in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer risk: a meta-analysis.
Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population.
Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population.
Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity.
Functional significance of different human CYP1A1 genotypes.
Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients.
Gefitinib: new preparation. Non small-cell lung cancer: stricter assessment needed.
Gender differences in genetic susceptibility for lung cancer.
Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility.
Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone.
Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in non-small cell lung cancer.
Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers.
Genetic determinants of CYP2A6 activity across racial/ethnic groups with different risks of lung cancer and effect on their smoking intensity.
Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study.
Genetic factors in individual responses to environmental exposures.
Genetic influence on cigarette-induced cardiovascular disease.
Genetic Mutation of p53 and Suppression of the miR-17?92 Cluster Are Synthetic Lethal in Non-Small Cell Lung Cancer due to Upregulation of Vitamin D Signaling.
Genetic Polymorphism of CYP2A6 and Its Relationship with Nicotine Metabolism in Male Bataknese Smokers Suffered from Lung Cancer in Indonesia.
Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.
Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers.
Genetic polymorphism of CYP2A6 in relation to cancer.
Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County.
Genetic polymorphism of CYP2D6 and lung cancer risk.
Genetic polymorphism of cytochrome P4502E1 in a Swedish population. Relationship to incidence of lung cancer.
Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: regulation and toxicological significance.
Genetic polymorphism of cytochromes P450: interethnic differences and relationship to incidence of lung cancer.
Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population.
Genetic polymorphism of xenobiotic metabolising enzymes in Slovenian lung cancer patients.
Genetic polymorphism of xenobiotic metabolizing enzymes among Chinese lung cancer patients.
Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1 metabolic genes and risk of lung cancer in Asturias.
Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer.
Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: implications for interindividual differences in nicotine metabolism.
Genetic polymorphisms of CYP1A1 and GSTM1 and lung cancer risk.
Genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes and lung cancer risk.
Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population.
Genetic polymorphisms of drug-metabolizing enzymes and lung cancer susceptibility.
Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer.
Genetic polymorphisms of NAD(P)H quinone oxidoreductase, CYP1A1 and microsomal epoxide hydrolase and lung cancer risk in Nanjing, China.
Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies.
Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers.
Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types.
Genetic variability in CYP2A6 and the pharmacokinetics of nicotine.
Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior.
Genome-wide association study of familial lung cancer.
Genomic copy number variations in three Southeast Asian populations.
Genotype relationships in the CYP3A locus in Caucasians.
Genotyping of the CYP2D6 gene in Norwegian lung cancer patients and controls.
Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with dual-labeled probes.
Germ line polymorphisms of p53 and CYP1A1 genes involved in human lung cancer.
Glutathione S-transferase M1 polymorphism and the risk of lung cancer.
GSTM1 and CYP1A1 Polymorphisms, Tobacco, Air Pollution, and Lung Cancer: A Study in Rural Thailand.
GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels.
Haplotypes in the 5'-untranslated region of the CYP1A2 gene are inversely associated with lung cancer risk but do not correlate with caffeine metabolism.
Host factors in lung cancer risk: a review of interdisciplinary studies.
Human CYP1A1 (cytochrome P(1)450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population.
Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.
Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo.
Human lung microsomal cytochrome P4501A1 (CYP1A1) activities: impact of smoking status and CYP1A1, aryl hydrocarbon receptor, and glutathione S-transferase M1 genetic polymorphisms.
Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.
Immunohistochemical detection of pulmonary cytochrome P450IA and metabolic activities associated with P450IA1 and P450IA2 isozymes in lung cancer patients.
In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility.
Increased expression of cytochrome P4501B1 in peripheral leukocytes from lung cancer patients.
Induction of aryl hydrocarbon hydroxylase activity and pulmonary carcinoma.
Induction of cytochrome P450 3A4 by docetaxel in peripheral mononuclear cells and its expression in lung cancer.
Influence of a mutation reducing the catalytic activity of the cytochrome P450 CYP2D6 on lung cancer susceptibility.
Influence of antioxidants and the CYP1A1 isoleucine to valine polymorphism on the smoking--lung cancer association.
Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population.
Influence of cytochrome P450 CYP2C9 genotypes in lung cancer risk.
Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans.
Influence of polymorphism at p53, CYP1A1 and GSTM1 loci on p53 mutation and association of p53 mutation with prognosis in lung cancer.
Inherent difficulties in epidemiological studies involving phenotyping.
Intake of flavonoids and lung cancer.
Interaction between CYP1A2-T2467DELT polymorphism and smoking in adenocarcinoma and squamous cell carcinoma of the lung.
Interaction between dose and susceptibility to environmental cancer: a short review.
Interaction of CYP1B1, cigarette-smoke carcinogen metabolism, and lung cancer risk.
Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer.
Interaction of the CYP1A1 gene polymorphism and smoking in non-small cell lung cancer susceptibility.
Interactions between cytotoxic chemotherapy and antiretroviral treatment in human immunodeficiency virus-infected patients with lung cancer.
Interactions between detoxifying enzyme polymorphisms and susceptibility to cancer.
Interactions between genetic predisposition and environmental toxicants for development of lung cancer.
Interactive effect of genetic polymorphism of glutathione S-transferase M1 and smoking on squamous cell lung cancer risk in Korea.
Interactive potential of genetic polymorphism in Xenobiotic metabolising and DNA repair genes for predicting lung cancer predisposition and overall survival in North Indians.
Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation.
Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation.
Investigating the influence of relevant pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of orally administered docetaxel combined with ritonavir.
Lack of associations among cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the physicians' health study.
Large interindividual variations in metabolism of benzo(alpha)pyrene by peripheral lung tissue from lung cancer patients.
Localization of CYP1A1 mRNA in human lung by in situ hybridization: comparison with immunohistochemical findings.
Lung cancer and CYP2D6 (the debrisoquine polymorphism): sources of heterogeneity in the proposed association.
Lung cancer in US women: a contemporary epidemic.
Lung cancer risk and CYP1A1 genotype in African Americans.
Lung cancer risk and genetic variants in East Asians: a meta-analysis.
Lung cancer risk in African-Americans in relation to a race-specific CYP1A1 polymorphism.
Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population.
Lung cancer risk in relation to the CYP2C9 genetic polymorphism among Caucasians in Los Angeles County.
Lung cancer risk in relation to the CYP2E1 Rsa I genetic polymorphism among African-Americans and Caucasians in Los Angeles County.
Lung cancer, race, and a CYP1A1 genetic polymorphism.
Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway.
MDR1 single nucleotide polymorphisms predict response to vinorelbine-based chemotherapy in patients with non-small cell lung cancer.
Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk.
Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease.
Meta-analysis of the CYP1A2 -163C>A Polymorphism and Lung Cancer Risk.
Metabolic cytochrome P450 genotypes and assessment of individual susceptibility to lung cancer.
Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation - a mammalian cell-based mutagenesis approach.
Metabolic gene polymorphisms and lung cancer risk in non-smokers An update of the GSEC study.
Metabolic Pathway of Icotinib In Vitro: The Differential Roles of CYP3A4, CYP3A5, and CYP1A2 on Potential Pharmacokinetic Drug-Drug Interaction.
Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans.
Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines.
Methodological issues in the interpretation of studies of the CYP2D6 genotype in relation to lung cancer risk.
MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1.
Mitogen-activated lymphocytes: a good model for characterising lung CYP1A1 inducibility.
Modulation of lung molecular biomarkers by beta-carotene in the Physicians' Health Study.
Molecular epidemiological study of non-small-cell lung cancer from an environmentally polluted region of Poland.
Molecular epidemiology: a new perspective for the study of toxic exposures in man. A consideration of the influence of genetic susceptibility factors on risk in different lung cancer histologies.
Molecular modeling of cytochrome P450 1A1: enzyme-substrate interactions and substrate binding affinities.
Mutant genes of cytochrome P-450IID6, glutathione S-transferase class Mu, and arylamine N-acetyltransferase in lung cancer patients.
NAT2 and CYP1A2 polymorphisms and lung cancer risk in relation to smoking status.
NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in Taiwan.
New opportunities in cancer risk evaluation using PCR-based DNA analysis for CYP2D6.
Nicotine Metabolism and Smoking: Ethnic Differences in the Role of P450 2A6.
Nicotine metabolism in three ethnic/racial groups with different risks of lung cancer.
Note of clarification of data on the association between CYP2E1 RsaI polymorphism and lung cancer risk.
Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.
Novel human CYP2A6 alleles confound gene deletion analysis.
Oncogenic Potential of CYP24A1 in Lung Adenocarcinoma.
Overexpression of cytochrome P450 1B1 in advanced non-small cell lung cancer: a potential therapeutic target.
p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer.
p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms.
Particulate matter less than 10??m (PM10) activates cancer related genes in lung epithelial cells.
PCR-based CYP2D6 genotyping for Finnish lung cancer patients.
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Pharmacogenetics of solid tumors: directed therapy in breast, lung, and colorectal cancer: a paper from the 2008 william beaumont hospital symposium on molecular pathology.
Pharmacogenetics: detecting sensitive populations.
Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects.
Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics.
Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.
Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis.
Pleomorphic (giant and/or spindle cell) carcinoma of lung shows a high percentage of variant CYP1A12.
Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population.
Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2.
Polycyclic aromatic hydrocarbon-DNA adducts and the CYP1A1 restriction fragment length polymorphism.
Polycyclic aromatic hydrocarbon-DNA adducts in human placenta and modulation by CYP1A1 induction and genotype.
Polymorphic CYP genes and disease predisposition--what have the studies shown so far?
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Polymorphism analysis of the CYP1A1 locus in Koreans: presence of the solitary m2 allele.
Polymorphism in CYP1A1 and CYP2D6 genes: possible association with susceptibility to lung cancer.
Polymorphism in CYP24A1 Is Associated with Lung Cancer Risk: A Case-Control Study in Chinese Female Nonsmokers.
Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men.
Polymorphism of cytochrome p450, glutathione-s-transferase and N-acetyltransferases: influence on lung cancer susceptibility.
Polymorphism of metabolizing genes and lung cancer histology: prevalence of CYP2E1 in adenocarcinoma.
Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer.
Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients.
Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years.
Polymorphisms in GSTM1, CYP1A1, CYP2E1, and CYP2D6 are Associated with Susceptibility and Chemotherapy Response in Non-small-cell Lung Cancer Patients.
Polymorphisms in the human CYP1A1 gene as susceptibility factors for lung cancer: exon-7 mutation (4889 A to G), and a T to C mutation in the 3'-flanking region.
Polymorphisms of CYP2A6 and its practical consequences.
Polymorphisms of human Ah receptor gene are not involved in lung cancer.
Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer.
Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population.
Polymorphisms of the GSTM1 and CYP2D6 genes associated with susceptibility to lung cancer in Chinese.
Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States).
Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes.
Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population.
Potentially estrogenic polychlorinated biphenyls congeners serum levels and its relation with lung cancer.
Prediction of lung cancer using volatile biomarkers in breath.
Pregnane X receptors regulate CYP2C8 and P-glycoprotein to impact on the resistance of NSCLC cells to Taxol.
Profiling gene expression of whole cytochrome P450 superfamily in human bronchial and peripheral lung tissues: Differential expression in non-small cell lung cancers.
Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule.
Prognostic significance of germ line polymorphisms of the CYP1A1 and glutathione S-transferase genes in patients with non-small cell lung cancer.
Protease inhibitors exposure is not related to lung cancer risk in HIV smoker patients: a nested case-control study.
Pulmonary CYP2A13 levels are associated with early occurrence of lung cancer-Its implication in mutagenesis of non-small cell lung carcinoma.
Pulmonary drug-metabolizing enzyme in alveolar macrophages in relation to cigarette smoking.
Pulmonary expression of CYP2A13 and ABCB1 is regulated by FOXA2 and their genetic interaction is associated with lung cancer.
Questionable relation of aryl hydrocarbon hydroxylase to lung-cancer risk.
Rapid detection of single nucleotide polymorphisms related with lung cancer susceptibility of Chinese population.
Re: London,S.J. et al. (1997) Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County. Carcinogenesis, 18, 1203-1214.
Re: S. J. London et al., Lung cancer risk in African-Americans in relation to a race-specific CYP1A1 polymorphism. Cancer Res., 55: 6035-6037, 1995.
Reassessment of the relationship between aryl hydrocarbon hydroxylase and lung cancer.
Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer.
Relation between inducibility of CYP1A1, GSTM1 and lung cancer in a French population.
Relationship between ambient air pollution and DNA damage in Polish mothers and newborns.
Relationship between CYP1B1 polymorphisms (c.142C > G, c.355G > T, c.1294C > G) and lung cancer risk in Polish smokers.
Relationship Between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 Variation and Smoking Behaviors and Lung Cancer Risk.
Relevance of metabolic polymorphisms to human carcinogenesis: evaluation of epidemiologic evidence.
Respiratory tract uptake of inhalants and metabolism of xenobiotics.
Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer: possible relevance to low smoking exposure.
Retraction: CYP1A2 rs2069514 polymorphism and lung cancer susceptibility: a meta-analysis.
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of environmental tobacco smoke and lung cancer: a case-control study in Japanese nonsmoking women.
Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism.
Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population.
Role of CYP1A2 polymorphisms on lung cancer risk in a prospective study.
Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment.
Role of estrogen receptor in regulation of polycyclic aromatic hydrocarbon metabolic activation in lung.
Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP.
Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers.
Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma.
Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes.
Sex differences in lung CYP1A1 expression and DNA adduct levels among lung cancer patients.
Sex differences in risk of lung cancer: Expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts.
Smoking and peripheral type of cancer are related to high levels of pulmonary cytochrome P450IA in lung cancer patients.
Smoking habit and genetic factors associated with lung cancer in a population highly exposed to arsenic.
Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients.
Structure and polymorphisms of human aryl hydrocarbon receptor repressor (AhRR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer.
Structure of the human lung cytochrome P450 2A13.
Structure, Function, Regulation and Polymorphism of Human Cytochrome P450 2A6.
Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands.
Study design and genetic susceptibility factors in the risk assessment of chemical carcinogens.
Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.
Susceptibility of lung cancer with polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 genotypes in the population of Inner Mongolia region.
Susceptibility to lung cancer and genetic polymorphisms in the alcohol metabolite-related enzymes alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 in the Japanese population.
Susceptibility to lung cancer in light smokers associated with CYP1A1 polymorphisms in Mexican- and African-Americans.
Synergistic association of CYP1A1 polymorphisms with increased susceptibility to squamous cell lung cancer in north Indian smokers.
Synergistic association of PTGS2 and CYP2E1 genetic polymorphisms with lung cancer risk in northeastern Chinese.
Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.
The correlation of combined OGG1, CYP1A1 and GSTP1 gene variants and risk of lung cancer of male Iraqi waterpipe tobacco smokers.
The CYP1A1 gene and cancer susceptibility.
The CYP1B1 Leu432Val polymorphism contributes to lung cancer risk: Evidence from 6501 subjects.
The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking dose.
The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independently of its catalytic activity.
The effect of cigarette smoke on aryl hydrocarbon hydroxylase activity and cytochrome P450 content in rat liver and lung microsomes.
The effect of CYP1A1 polymorphisms on the risk of lung cancer: a global meta-analysis based on 71 case-control studies.
The effect of CYP1A1, GSTT1 and GSTM1 polymorphisms on the risk of lung cancer: A case-control study.
The Effect of Rifampin on the Pharmacokinetics and Safety of Lorlatinib: Results of a Phase One, Open-Label, Crossover Study in Healthy Participants.
The effect of tobacco on lung cancer risk depends on CYP2D6 activity.
The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene.
The heme-binding region polymorphism of cytochrome P450IA1 (CypIA1), rather than the RsaI polymorphism of IIE1 (CypIIE1), is associated with lung cancer in Rio de Janeiro.
The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population.
The Impact of IL-16 3'UTR Polymorphism rs859 on Lung Carcinoma Susceptibility among Chinese Han Individuals.
The interaction between smoking and CYP1A1 MspI polymorphism on lung cancer: a meta-analysis in the Chinese population.
The polymorphism of CYP2E1 Rsa I/Pst I gene and susceptibility to respiratory system cancer: a systematic review and meta-analysis of 34 studies.
The regulation mechanism of AhR activated by benzo[a]pyrene for CYP expression are different between 2D and 3D culture of human lung cancer cells.
The relationship between aryl hydrocarbon hydroxylase activity and DNA adducts measured by (32)P-postlabelling assay in lymphocytes of lung cancer patients.
The relationship between CYP1A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population.
The role of CYP1A1 Msp1 gene polymorphisms on lung cancer development in Turkey.
The role of metabolism in chemical-induced pulmonary toxicity.
The role of molecular epidemiology in cancer prevention.
The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of lung cancer: a meta-analysis.
Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.
Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells.
Transplacental lung carcinogenesis: a pharmacogenetic mouse model for the modulatory role of cytochrome P450 1A1 on lung cancer initiation.
Treatment of lung cancer patients and concomitant use of drugs interacting with cytochrome P450 isoenzymes.
Updated meta-analysis of the association between CYP2E1 RsaI/PstI polymorphisms and lung cancer risk in Chinese population.
Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms.
Variation in CYP2A6 Activity and Personalized Medicine.
Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer.
[A case control study on the impact of CYP450 MSPI and GST-M1 polymorphisms on the risk of lung cancer]
[A case-control study on the association between genetic polymorphisms of metabolizing enzymes CYP2D6 and susceptibility to lung cancer.]
[A case-control study on the impact of cytochrome P450 2E1 and 1A1 gene polymorphisms on the risk of lung can- cer of the Han nationality in Guangzhou district.]
[A role of aryl hydrocarbon hydroxylase inducibility in susceptibility to lung carcinogenesis]
[Allelic distribution of the CYP1A1 in lung cancer patients, middle-aged tissue donors and in elderly people without cancer]
[Application of molecular biology to occupational health field--the frequency of gene polymorphism of cytochrome P450 1A1 and glutathione S-transferase M1 in patients with lung, oral and urothelial cancer]
[Applications of aryl hydrocarbon hydroxylase in diagnosis of lung cancer]
[Aryl hydrocarbon hydroxylase level as a possible risk indicator of susceptibility to lung cancer]
[Association of CYP1A1 Ile462Val polymorphisms with susceptibility to small cell lung cancer].
[Association of cytochrome P-450 1A1 (CYP1A1) gene polymorphism to smoking status and hematologic findings]
[Combined effects of genetic polymorphisms in cytochrome P450s and GSTM1 on lung cancer susceptibility]
[CYP1A1 Gene and GSTM1 Gene Polymorphism and the Combined Effects and Risk of Lung Cancer: A meta-analysis].
[CYP1A1 polymorphisms, lack of glutathione S-transferase M1 (GSTM1), cooking oil fumes and lung cancer risk in non-smoking women].
[CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility]
[Evidence based prevention (EBP): evidence-based approach to prevention of lung cancer by application of cytochrome 2E1 polymorphism]
[Frequency of CYP2A6 gene deletion and its relation to risk of lung cancer.]
[Genetic and phenotypic polymorphisms in carcinogen-metabolizing enzymes and cancer susceptibility]
[Genetic determination of aryl hydrocarbon hydroxylase activity and its significance in the etiology of lung cancer]
[Genetic polymorphisms of CYP1A1 and susceptibility of lung cancer]
[How I was enticed into molecular toxicology]
[Individual susceptibility to occupational carcinogens: the evidence from biomonitoring and molecular epidemiology studies]
[Metabolic polymorphisms and the cancer risk: the evaluation of epidemiological studies]
[Polymorphisms of the CYP1A1 and GSTM1 genes and their combined effects on individual susceptibility to lung cancer in a Chinese population]
[Preliminary study on the expression of aromatase P450 mRNA in human lung cancer tissues.]
[Relation between cytochrome P450 2D6 and lung cancer susceptibility caused by smoking]
[Relationship between CYP1A1 and GSTM1 genetic polymorphisms and lung cancer susceptibility in population of Inner Mongolia.]
[Relationship between genetic polymorphism of metabolizing enzymes and lung cancer susceptibility.]
[Role of ancestral genotypes of the genes of xenobiotics biotransformation in susceptibility to lung cancer among Mayak workers].
[Role of cytochrome P4501A1 (CYP1A1) in lung cancer sensitivity]
[Role of metabolic polymorphisms in lung carcinogenesis]
[Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China.]
[Study on the association between genetic polymorphism of CYP2E1, GSTM1 and susceptibility of lung cancer.]
[Study on the relationship between polymorphisms of CYP1A1 gene and susceptibility of lung cancer in Sichuan population.]
[Susceptibility to bronchial cancer: an example of genetic-environmental interaction]
[Susceptibility to lung cancer in Chinese is associated with genetic polymorphism in cytochrome P4502E1]
[The relationship between genetic polymorphism of metabolizing enzymes and the genetic susceptibility to lung cancer]
[The strategic use of genetic polymorphisms in carcinogen metabolizing enzyme for prevention of cancer]
Lupus Erythematosus, Systemic
Association between Functional CYP2D6 Polymorphisms and Susceptibility to Autoimmune Diseases: A Meta-Analysis.
Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population.
Association of Polymorphisms of Cytochrome P450 2D6 With Blood Hydroxychloroquine Levels in Patients With Systemic Lupus Erythematosus.
Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus.
Cyclophosphamide boluses induce micronuclei expression in buccal mucosa cells of patients with systemic lupus erythematosus independent of cytochrome P450 2D6 status.
CYP2D6 polymorphism in systemic lupus erythematosus patients.
Cytochrome P450 and manganese superoxide dismutase genes polymorphisms in systemic lupus erythematosus.
Cytochrome P450 Polymorphism as a Predictor of Ovarian Toxicity to Pulse Cyclophosphamide in Systemic Lupus Erythematosus.
Cytochrome P450 polymorphism as a predictor of ovarian toxicity to pulse cyclophosphamide in systemic lupus erythematosus.
Genetic analysis of the cytochrome P450 CYP2D6 polymorphism in patients with systemic lupus erythematosus.
Genetic markers in CYP2C19 and CYP2B6 for prediction of cyclophosphamide's 4-hydroxylation, efficacy and side effects in Chinese patients with systemic lupus erythematosus.
Genetic polymorphism of CYP2D6 in patients with systemic lupus erythematosus and systemic sclerosis.
Genetic polymorphisms of CYP2D6 oxidation in patients with systemic lupus erythematosus.
Genetic polymorphisms of glutathione S-transferases and cytochrome P450 enzymes as susceptibility factors to systemic lupus erythematosus in southern Brazilian patients.
Initial dose optimization of tacrolimus for children with systemic lupus erythematosus based on the CYP3A5 polymorphism and coadministration with Wuzhi capsule.
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice.
Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of cigarette smoking and systemic lupus erythematosus in a Japanese population.
Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3.
Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population.
The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.
Lupus Nephritis
Analysis of cytochrome P450 gene polymorphism in a lupus nephritis patient in whom tacrolimus blood concentration was markedly elevated after administration of azole antifungal agents.
Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis.
Cytochrome P450 polymorphisms and the response of lupus nephritis to cyclophosphamide therapy.
Effects of CYP3A5 polymorphism and the tacrolimus 12?h concentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis.
Epistatic interactions among CYP2C19*2, CYP3A4 and GSTP1 on the cyclophosphamide therapy in lupus nephritis patients.
Use of Enantiomeric Bupropion and Hydroxybupropion to Assess CYP2B6 Activity in Glomerular Kidney Diseases.
Lymphadenitis
Antitumor effects and mechanisms of 1,25(OH)2D3 in the Pfeiffer diffuse large B lymphoma cell line.
Lymphadenopathy
Management of Locally Advanced Esthesioneuroblastoma in a Pregnant Woman.
Lymphatic Metastasis
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.
CYP24A1 is a potential biomarker for the progression and prognosis of human colorectal cancer.
CYP27A1 and CYP24 expression as a function of malignant transformation in the colon.
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-?-catenin signalling, the stem cell phenotype and disease progression.
miR-30a promoter variation contributes to the increased risk of colorectal cancer in an Iranian population.
Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers.
Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.
Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer.
[Study on the Difference of Gene Expression between Central and Peripheral Lung Squamous Cell Carcinoma Based on TCGA Database].
Lymphedema
CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients?
Lymphoma
Cytochrome P450 2B6*5 Increases Relapse after Cyclophosphamide-Containing Conditioning and Autologous Transplantation for Lymphoma.
Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.
Effect of the Cytochrome P450 2C19 Inhibitor Omeprazole on the Pharmacokinetics and Safety Profile of Bortezomib in Patients with Advanced Solid Tumours, Non-Hodgkin's Lymphoma or Multiple Myeloma.
Effects of Strong CYP2C8 or CYP3A Inhibition and CYP3A Induction on the Pharmacokinetics of Brigatinib, an Oral Anaplastic Lymphoma Kinase Inhibitor, in Healthy Volunteers.
Endogenous xenobiotic enzyme levels in mammalian cells.
Expression of CYP3A4 as a predictor of response to chemotherapy in peripheral T-cell lymphomas.
Genetic polymorphisms and vincristine-induced peripheral neuropathy in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy.
Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas.
Genetically dominant resistance in mice to 3-methylcholanthrene-induced lymphoma.
Human bronchial epithelial cells exposed in vitro to diesel exhaust particles exhibit alterations in cell rheology and cytotoxicity associated with decrease in antioxidant defenses and imbalance in pro- and anti-apoptotic gene expression.
Pien Tze Huang Gan Bao attenuates carbon tetrachloride?induced hepatocyte apoptosis in rats, associated with suppression of p53 activation and oxidative stress.
Safety Evaluation of a Proprietary Food-Grade, Dried Fermentate Preparation of Saccharomyces cerevisiae.
The -omics era and its impact.
The Effect of Rifampin on the Pharmacokinetics and Safety of Lorlatinib: Results of a Phase One, Open-Label, Crossover Study in Healthy Participants.
[Effect and mechanism of liraglutide on the apoptosis of human hepatocellular carcinoma HepG2 cells induced with palmitic acid].
[Study on mesenchymal stem cells mediated enzyme-prodrug gene CYP1A2 targeting anti-tumor effect]
Lymphoma, B-Cell
Antioxidant, anti-inflammatory and anti-apoptotic effects of hydro-ethanolic extract of Cyperus esculentus L. (tigernut) on lead acetate-induced testicular dysfunction in Wistar rats.
Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
Genetic polymorphisms and vincristine-induced peripheral neuropathy in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy.
Irbesartan mitigates acute liver injury, oxidative stress, and apoptosis induced by acetaminophen in mice.
Metabolic gene variants and risk of non-Hodgkin's lymphoma.
Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population.
Synthesis and Evaluation of Novel Cholestanoheterocyclic Steroids as Anticancer Agents.
[Effect and mechanism of liraglutide on the apoptosis of human hepatocellular carcinoma HepG2 cells induced with palmitic acid].
Lymphoma, Follicular
Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival.
Lymphoma, Large B-Cell, Diffuse
Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population.
Lymphoma, Mantle-Cell
Effect of the Cytochrome P450 2C19 Inhibitor Omeprazole on the Pharmacokinetics and Safety Profile of Bortezomib in Patients with Advanced Solid Tumours, Non-Hodgkin's Lymphoma or Multiple Myeloma.
Lymphoma, Non-Hodgkin
Association of Non-Hodgkin lymphoma risk with CYP1A1, GSTM1 and GSTT1 gene variants, in tobacco addicted patients of Pashtun ethnicity of Khyber Pakhtunkhwa, Pakistan.
Cytochrome P450 Genetic Variations Can Predict mRNA Expression, Cyclophosphamide 4-Hydroxylation, and Treatment Outcomes in Chinese Patients With Non-Hodgkin's Lymphoma.
Effect of cytochrome P450 3A4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or non-Hodgkin's lymphoma.
Effect of the Cytochrome P450 2C19 Inhibitor Omeprazole on the Pharmacokinetics and Safety Profile of Bortezomib in Patients with Advanced Solid Tumours, Non-Hodgkin's Lymphoma or Multiple Myeloma.
Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma.
Genetic Variations in Xenobiotic Metabolic Pathway Genes, Personal Hair Dye Use, and Risk of Non-Hodgkin Lymphoma.
Metabolic gene variants and risk of non-Hodgkin's lymphoma.
[Activity and induction of CYP2B, CYP2C, and CYP3A in tissues of cyclophosphane-sensitive and resistant neoplasms and the liver of neoplasm-carrying mice]
Lymphoma, T-Cell
Effects of paclitaxel, docetaxel and their combinations on subcutaneous lymphomas in inbred Sprague-Dawley/Cub rats.
Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphoma.
Lymphoproliferative Disorders
Raltegravir: new Drug. Alternative to enfuvirtide/darunavir in multidrug-resistant HIV.
Macular Degeneration
Associations between CYP2C8 rs10509681 and rs11572080 gene polymorphisms and age-related macular degeneration.
Associations between Rs4244285 and Rs762551 gene polymorphisms and age-related macular degeneration.
Cytochrome P450 2C Epoxygenases Mediate Photochemical Stress-induced Death of Photoreceptors.
Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1.
Post-translational Modification by an Isolevuglandin Diminishes Activity of the Mitochondrial Cytochrome P450 27A1.
Malabsorption Syndromes
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Malaria
A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy.
Age-related pyrethroid resistance is not a function of P450 gene expression in the major African malaria vector, Anopheles funestus (Diptera: Culicidae).
Allelic Variation of Cytochrome P450s Drives Resistance to Bednet Insecticides in a Major Malaria Vector.
Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.
An adult-specific CYP6 P450 gene is overexpressed in a pyrethroid-resistant strain of the malaria vector, Anopheles gambiae.
An expression of an insect membrane-bound cytochrome P450 CYP6AA3 in the Escherichia coli in relation to insecticide resistance in a malarial vector.
Analysis of Sepik populations of Papua New Guinea suggests an increase of CYP2C19 null allele frequencies during the colonization of Melanesia.
Characterization of Anopheles minimus CYP6AA3 expressed in a recombinant baculovirus system.
Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus.
Cloning of cytochrome P450, CYP6P5, and CYP6AA2 from Anopheles minimus resistant to deltamethrin.
Combined over-expression of two cytochrome P450 genes exacerbates the fitness cost of pyrethroid resistance in the major African malaria vector Anopheles funestus.
Correction: Cytochrome P450 metabolic resistance (CYP6P9a) to pyrethroids imposes a fitness cost in the major African malaria vector Anopheles funestus.
CYP2B6*6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response in HIV-malaria-coinfected patients.
CYP2C8 polymorphism frequencies among malaria patients in Zanzibar.
CYP2C8 status of patients with malaria influences selection of Plasmodium falciparum pfmdr1 alleles after amodiaquine-artesunate treatment.
CYP2D6 activity and the risk of recurrence of Plasmodium vivax malaria in the Brazilian Amazon: a prospective cohort study.
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region.
CYP2D6 Genetic Variation and Its Implication for Vivax Malaria Treatment in Madagascar.
CYP2D6 variability in populations from Venezuela.
CYP6 P450 Enzymes and ACE-1 Duplication Produce Extreme and Multiple Insecticide Resistance in the Malaria Mosquito Anopheles gambiae.
Cytochrome 1A1 induction by primaquine in human hepatocytes and HepG2 cells: absence of binding to the aryl hydrocarbon receptor.
Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed.
Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection.
Cytochrome P450 metabolic resistance (CYP6P9a) to pyrethroids imposes a fitness cost in the major African malaria vector Anopheles funestus.
Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes.
Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus.
Distribution of human CYP2C8*2 allele in three different African populations.
Diversity of cytochrome P450 genes in the mosquito, Anopheles albimanus.
Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes.
Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women.
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase 2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania.
Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians.
Evaluation of efficacy and safety of a herbal medicine used for the treatment of malaria.
Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation.
Genetic variability of CYP2B6 polymorphisms in southeast Iranian population: implications for malaria and HIV/AIDS treatment.
Genome-wide and expression-profiling analyses suggest the main cytochrome P450 genes related to pyrethroid resistance in the malaria vector, Anopheles sinensis (Diptera Culicidae).
HIV-Positive Nigerian Adults Harbor Significantly Higher Serum Lumefantrine Levels than HIV-Negative Individuals Seven Days after Treatment for Plasmodium falciparum Infection.
Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes.
In vitro analysis of the interaction between Atovaquone and Proguanil against malaria liver stage.
Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate-amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar.
Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450.
Isolation and sequence analysis of P450 genes from a pyrethroid resistant colony of the major malaria vector Anopheles funestus.
Malaria downmodulates mRNA expression and catalytic activities of CYP1A2, 2E1 and 3A11 in mouse liver.
Mefloquine resistance reversal action of ketoconazole - a cytochrome P450 inhibitor, against mefloquine-resistant malaria.
Microarray and RNAi analysis of P450s in Anopheles gambiae male and female steroidogenic tissues: CYP307A1 is required for ecdysteroid synthesis.
Molecular analysis of multiple cytochrome P450 genes from the malaria vector, Anopheles gambiae.
Molecular basis of permethrin and DDT resistance in an Anopheles funestus population from Benin.
Multiple relapses of Plasmodium vivax malaria acquired from West Africa and association with poor metabolizer CYP2D6 variant: a case report.
Novel insights into Plasmodium vivax therapeutic failure: CYP2D6 activity and time of exposure to malaria modulate the risk of recurrence.
Over expression of a cytochrome P450 (CYP6P9) in a major African malaria vector, Anopheles Funestus, resistant to pyrethroids.
Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
Positional cloning of rp2 QTL associates the P450 genes CYP6Z1, CYP6Z3 and CYP6M7 with pyrethroid resistance in the malaria vector Anopheles funestus.
Possible isozyme-specific effects of experimental malaria infection with Plasmodium berghei on cytochrome P450 activity in rat liver microsomes.
Preliminary investigation of the contribution of CYP2A6, CYP2B6, and UGT1A9 polymorphisms on artesunate-mefloquine treatment response in Burmese patients with Plasmodium falciparum malaria.
Prevalence of CYP2D6 Genotypes and Predicted Phenotypes in a Cohort of Cambodians at High Risk for Infections with Plasmodium vivax.
Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations.
Protective efficacy of Anopheles minimus CYP6P7 and CYP6AA3 against cytotoxicity of pyrethroid insecticides in Spodoptera frugiperda (Sf9) insect cells.
Pyrethroid Resistance in the Major Malaria Vector Anopheles funestus is Exacerbated by Overexpression and Overactivity of the P450 CYP6AA1 Across Africa.
Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines.
Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial.
The cytochrome P450 CYP325A is a major driver of pyrethroid resistance in the major malaria vector Anopheles funestus in Central Africa.
The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria.
The effects of acute falciparum malaria on the disposition of caffeine and the comparison of saliva and plasma-derived pharmacokinetic parameters in adult Nigerians.
The highly polymorphic CYP6M7 cytochrome P450 gene partners with the directionally selected CYP6P9a and CYP6P9b genes to expand the pyrethroid resistance front in the malaria vector Anopheles funestus in Africa.
The interplay between tubulins and P450 cytochromes during Plasmodium berghei invasion of Anopheles gambiae midgut.
The lncRNA-miRNA-mRNA ceRNA network in mural granulosa cells of patients with polycystic ovary syndrome: an analysis of Gene Expression Omnibus data.
The oxylipin and endocannabidome responses in acute phase Plasmodium falciparum malaria in children.
The P450 CYP6Z1 confers carbamate/pyrethroid cross-resistance in a major African malaria vector beside a novel carbamate-insensitive N485I acetylcholinesterase-1 mutation.
The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor.
The Prevalence of CYP2B6 Gene Polymorphisms in Malaria-endemic Population of Timor in East Nusa Tenggara Indonesia.
Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major malaria vector.
Two functionally distinct CYP4G genes of Anopheles gambiae contribute to cuticular hydrocarbon biosynthesis.
Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa.
Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria models.
[Deltamethrin resistance, metabolic detoxification enzyme and kdr mutation in Anopheles sinensis in region along Huaihe River in Anhui Province].
[Microsomal monooxygenase inhibitors as promising agents for overcoming the drug resistance of the malaria parasite]
Malaria, Falciparum
Analysis of Sepik populations of Papua New Guinea suggests an increase of CYP2C19 null allele frequencies during the colonization of Melanesia.
Distribution of human CYP2C8*2 allele in three different African populations.
Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate-amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar.
Preliminary investigation of the contribution of CYP2A6, CYP2B6, and UGT1A9 polymorphisms on artesunate-mefloquine treatment response in Burmese patients with Plasmodium falciparum malaria.
Malaria, Vivax
Association of Impaired Cytochrome P450 2D6 Activity Genotype and Phenotype With Therapeutic Efficacy of Primaquine Treatment for Latent Plasmodium vivax Malaria.
Case report: recurrence of Plasmodium vivax malaria due to defective cytochrome P450 2D6 function in Pos Lenjang, Pahang, Malaysia.
CYP2D6 activity and the risk of recurrence of Plasmodium vivax malaria in the Brazilian Amazon: a prospective cohort study.
CYP2D6 Genetic Variation and Its Implication for Vivax Malaria Treatment in Madagascar.
CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum.
Impact of CYP2D6 Genetic Variation on Radical Cure of Plasmodium vivax Malaria.
Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients.
Multiple relapses of Plasmodium vivax malaria acquired from West Africa and association with poor metabolizer CYP2D6 variant: a case report.
Novel insights into Plasmodium vivax therapeutic failure: CYP2D6 activity and time of exposure to malaria modulate the risk of recurrence.
Primaquine ineligibility in anti-relapse therapy of Plasmodium vivax malaria: the problem of G6PD deficiency and cytochrome P-450 2D6 polymorphisms.
Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study.
Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial.
The association of CYP2D6 gene polymorphisms in the full-length coding region with higher recurrence rate of vivax malaria in Yunnan Province, China.
Malnutrition
Alcohol and liver cancer.
Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis.
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test.
Effect of protein and calorie malnutrition on drug metabolism in rat - in vitro.
Effects of malnutrition on cytochrome P450 1A2 activity in elderly patients.
Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis.
Liver glutathione and cytochrome P450 activity in experimental infection: study of the relative effects of infectious stress and malnutrition.
Long-term acid inhibition: benefits and harms.
Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine.
The effect of obesity, macronutrients, fasting and nutritional status on drug-metabolizing cytochrome P450s: a systematic review of current evidence on human studies.
The sample that would not clot.
Undernutrition during hyperoxic exposure induces CYP2E1 in rat liver.
Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition.
[Activity of delta-aminolevulinic synthetase, cytochrome oxidase and levels of the mixed function oxidase system during experimental protein malnutrition. Response to re-alimentation]
Manganese Poisoning
Polymorphism of metabolic genes and susceptibility to occupational chronic manganism.
Mania
Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N?=?1345 young and elderly subjects.
Role of Pharmacogenetics in Improving the Safety of Psychiatric Care by Predicting the Potential Risks of Mania in CYP2D6 Poor Metabolizers Diagnosed With Bipolar Disorder.
Marfan Syndrome
Variants in ADRB1 and CYP2C9: Association with Response to Atenolol and Losartan in Marfan Syndrome.
Mastitis
CYP1A1 Relieves Lipopolysaccharide-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells.
Feeding supplemental 25-hydroxyvitamin D3 increases serum mineral concentrations and alters mammary immunity of lactating dairy cows.
Intramammary 1,25-dihydroxyvitamin D3 treatment increases expression of host-defense genes in mammary immune cells of lactating dairy cattle.
Widespread basal cytochrome P450 expression in extrahepatic bovine tissues and isolated cells.
Mastocytoma
Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids.
Medullary Sponge Kidney
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Medulloblastoma
CYP1A1 and CYP1B1 expressions in medulloblastoma cells are AhR-independent and have no direct link with resveratrol-induced differentiation and apoptosis.
Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target.
Differential regulation of CYP1A1 and CYP1B1 expression in resveratrol-treated human medulloblastoma cells.
Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia?inducible factor 1??mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation.
P450-expression in brain tumors.
Melanoma
Antiproliferative Activity of Non-Calcemic Vitamin D Analogs on Human Melanoma Lines in Relation to VDR and PDIA3 Receptors.
Application of Homolgy Modeling to Generate CYP1A1 Mutants with Enhanced Activation of the Cancer Chemotherapeutic Prodrug Dacarbazine.
CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.
CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.
Cytochrome P450 CYP2D6 genotypes: association with hair colour, Breslow thickness and melanocyte stimulating hormone receptor alleles in patients with malignant melanoma.
Different h2 receptor antihistamines dissimilarly retard the growth of xenografted human melanoma cells in immunodeficient mice.
Epigenetic silencing of novel tumor suppressors in malignant melanoma.
Functional significance of cytochrome P450 1B1 in endometrial carcinogenesis.
Generation, Validation, and Application of a P450 Homology Model.
Genetic susceptibility to environmental carcinogenesis in Slovenian melanoma patients.
Genetics in melanoma.
Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4.
Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study.
Metabolic bioactivation and toxicity of ethyl 4-hydroxybenzoate in human SK-MEL-28 melanoma cells.
Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1.
No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case-control study.
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
On the relationship between VDR, ROR? and ROR? receptors expression and HIF1-? levels in human melanomas.
On the role of classical and novel forms of vitamin D in melanoma progression and management.
Rat CYP24A1 acts on 20-hydroxyvitamin D(3) producing hydroxylated products with increased biological activity.
Selective Antitumor Effect of Shikonin Derived DMAKO-20 on Melanoma through CYP1B1.
Structural toxicity relationship of 4-alkoxyphenols' cytotoxicity towards murine B16-F0 melanoma cell line.
Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer.
Targeted delivery of CYP2E1 recombinant adenovirus to malignant melanoma by bone marrow-derived mesenchymal stem cells as vehicles.
The association between Parkinson's disease and melanoma.
Vitamin D receptors (VDR), hydroxylases CYP27B1 and CYP24A1 and retinoid-related orphan receptors (ROR) level in human uveal tract and ocular melanoma with different melanization levels.
Melanosis
Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays.
Memory Disorders
CYP1B1 deiciency ameliorates learning and memory deficits caused by high fat diet in mice.
Meningeal Neoplasms
Expression Profile of Genes Related to Drug Metabolism in Human Brain Tumors.
Meningioma
Debrisoquine hydroxylase gene polymorphism in meningioma.
Forkhead Box M1 promotes the growth and tube formation of human malignant meningioma cells via the aryl hydrocarbon receptor signaling pathway.
Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors.
Overexpression of aryl hydrocarbon receptor (AHR) signalling pathway in human meningioma.
Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci.
Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors.
[Intracranial approach in the excision of olfactive meningioma with nasal prolongation.]
[Nasal prolongation of olfactive meningiomas]
Meningitis
Differential alterations in levels of hepatic microsomal cytochrome P450 isozymes following intracerebroventricular injection of bacterial lipopolysaccharide in rats.
Meningocele
[Congenital bilateral dacryocystitis and craniofacial dysraphia]
Menorrhagia
Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking.
Mesothelioma
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Expression of mRNA for several enzymes of xenobiotic detoxification in normal and spontaneously transformed mesothelial cells and mesothelioma cells of rats.
Mesothelioma, Malignant
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations.
Metabolic Diseases
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Differential inhibition of naringenin on human and rat cytochrome P450 2E1 activity.
Enalapril reverses high-fat diet-induced alterations in cytochrome P450-mediated eicosanoid metabolism.
Potential role of CYP1B1 in the development and treatment of metabolic diseases.
Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia.
Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health.
The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases.
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models.
Metabolic Syndrome
17? Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats.
Age-dependent features of CYP3A, CYP2C, and CYP2E1 functioning at metabolic syndrome.
Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant.
Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study.
Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes.
CYP gene expressions in obesity-associated metabolic syndrome.
Cytochrome P450 2E1 participation in the pathogenesis of experimental metabolic syndrome in guinea pigs.
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11?-hydroxylase.
Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis.
In Vivo Exposures to Particulate Matter Collected from Saudi Arabia or Nickel Chloride Display Similar Dysregulation of Metabolic Syndrome Genes.
Metformin, Estrogen Replacement Therapy and Gonadotropin Inhibition Fail to Improve Insulin Sensitivity in a Girl with Aromatase Deficiency.
Physiogenomic analysis of CYP450 drug metabolism correlates dyslipidemia with pharmacogenetic functional status in psychiatric patients.
Roles of lipid mediators in kidney injury.
Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists.
The Associations of Novel Vitamin D3 Metabolic Gene CYP27A1 Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males.
The regulatory effect of genistein on P450 aromatase and follicle-stimulating hormone receptor in mouse experimental model of menopausal metabolic syndrome.
[Resistance to antiplatelet drugs in patients with cerebrovascular disorders].
Methemoglobinemia
Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-/-) knockout mice.
Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia.
Metrorrhagia
Risk-Benefit Assessment of Ethinylestradiol Using a Physiologically Based Pharmacokinetic Modeling Approach.
Migraine Disorders
A Metabolism-Based Synergy for Total Coumarin Extract of Radix Angelicae Dahuricae and Ligustrazine on Migraine Treatment in Rats.
Antiepileptic Drug Therapy in Migraine Headache.
Association of MDR1, CYP2D6, and CYP2C19 gene polymorphisms with prophylactic migraine treatment response.
Cytochrome P450 2D6 and glutathione S-transferase M1 genotypes and migraine.
Ergotism in Thailand caused by increased access to antiretroviral drugs: a global warning.
Investigation of polymorphisms in genes involved in estrogen metabolism in menstrual migraine.
The metabolism of zolmitriptan: effects of an inducer and an inhibitor of cytochrome p450 on its pharmacokinetics in healthy volunteers.
Miosis
A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans.
Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.
Mechanism of Efavirenz Influence on Methadone Pharmacokinetics and Pharmacodynamics.
Preclinical toxicology studies with nizatidine, a new H2-receptor antagonist: acute, subchronic, and chronic toxicity evaluations.
Mitochondrial Diseases
A case of cerebrotendinous xanthomatosis mimicking the clinical phenotype of mitochondrial disease with a novel frame-shift mutation (c. 43_44 delGG) in CYP27A1 gene exon 1.
Mouth Neoplasms
Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.
Alteration of the Risk of Oral Pre-Cancer and Cancer in North India Population by CYP1A1 Polymorphism Genotypes and Haplotype
Areca nut components stimulate ADAM17, IL-1?, PGE2 and 8-isoprostane production in oral keratinocyte: role of reactive oxygen species, EGF and JAK signaling.
Association between GSTM1 and CYP1A1 polymorphisms and survival in oral cancer patients.
Association of CYP1A1 and GSTM1 Polymorphisms With Oral Cancer Susceptibility: A Meta-Analysis.
Association of CYP1A1 MspI polymorphism with oral cancer risk in Asian populations: a meta-analysis.
Carcinoma of the oral cavity in relation to aryl hydrocarbon hydroxylase inducibility, smoking and dental status.
Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells.
CYP1A1 and GSTM1 polymorphisms and oral cancer risk.
CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses.
CYP1A1 and GSTP1 polymorphisms in an oral cancer case-control study.
CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians.
CYP1A1 polymorphism interactions with smoking status in oral cancer risk: evidence from epidemiological studies.
CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka.
CYP2E1 Rsa I/Pst I polymorphism contributes to oral cancer susceptibility: a meta-analysis.
CYP2E1 RsaI/PstI polymorphisms contributed to oral cancer susceptibility: a meta-analysis.
CYP3A5*1 is an inhibitory factor for lung cancer in Taiwanese.
Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls.
Elucidation of CYP2E1 5' regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer.
Frequency of the functionally relevant aryl hydrocarbon receptor repressor (AhRR) Pro185Ala SNP in Papua New Guinea.
Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from Gujarat, West India.
Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer.
Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer.
Genetic Polymorphisms of ADH1C and CYP2E1 and Risk of Oral Squamous Cell Carcinoma.
Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer.
Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1; environmental factors and risk of oral cancer.
Genetic Polymorphisms of the CYP2E1 Gene do not Contribute to Oral Cancer Susceptibility in South Indians.
Genetic Susceptibility to Oral Cancer due to Combined Effects of GSTT1, GSTM1 and CYP1A1 Gene Variants in Tobacco Addicted Patients of Pashtun Ethnicity of Khyber Pakhtunkhwa Province of Pakistan.
Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes.
GSTM1, GSTT1 and CYP1A1 polymorphisms and risk of oral cancer: a case-control study in Jakarta, Indonesia.
Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro.
Metabolic polymorphisms, smoking, and oral cancer in Puerto Rico.
Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells.
Oral cancer susceptibility associated with the CYP1A1 and GSTM1 genotypes in Chilean individuals.
p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use.
Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer.
Polymorphisms of CYP1A1, GSTM1 and GSTT1 Loci as the Genetic Predispositions of Oral Cancers and Other Oral Pathologies: Tobacco and Alcohol as Risk Modifiers.
Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols.
Prevalence of CYP1A1 and GST polymorphisms in the population of northeastern India and susceptibility of oral cancer.
Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6.
Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator.
Systems-level differential gene expression analysis reveals new genetic variants of oral cancer.
Vitamin D receptor, CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival.
[Application of molecular biology to occupational health field--the frequency of gene polymorphism of cytochrome P450 1A1 and glutathione S-transferase M1 in patients with lung, oral and urothelial cancer]
[Correlation between smoking and the polymorphisms of cytochrome P450 1A1-Msp I and glutathione S-transferase T1 genes and oral cancer].
Movement Disorders
Analysis of CYP2D6 genotype and response to tetrabenazine.
Antipsychotic drug-induced movement disorders in schizophrenics in relation to CYP2D6 genotype.
Association between CYP2D6 genotype and tardive dyskinesia in Korean schizophrenics.
Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
CYP2D6 genotype and antipsychotic-induced extrapyramidal side effects in schizophrenic patients.
Fluoxetine-induced movement disorders and deficient CYP2D6 enzyme activity.
Non-functional CYP2D6 alleles and risk for neuroleptic-induced movement disorders in schizophrenic patients.
Pharmacogenetic assessment of antipsychotic-induced movement disorders: contribution of the dopamine D3 receptor and cytochrome P450 1A2 genes.
Pharmacogenetics of response to antipsychotics in patients with schizophrenia.
Risperidone-associated adverse drug reactions and CYP2D6 polymorphisms in a South African cohort.
Mucocutaneous Lymph Node Syndrome
CYP2E1 Gene Polymorphisms Related to the Formation of Coronary Artery Lesions in Kawasaki Disease.
Height, VKORC1 1173, and CYP2C9 Genotypes Determine Warfarin Dose for Pediatric Patients with Kawasaki Disease in Southwest China.
Mucositis
Temsirolimus and mantle cell lymphoma. Highly toxic, limited efficacy.
Multiple Chemical Sensitivity
Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR.
Multiple Myeloma
A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer.
Association between CYP2C8 (rs1934951) Polymorphism and Bisphosphonate-Related Osteonecrosis of the Jaws in Patients on Bisphosphonate Therapy: A Meta-Analysis.
Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma.
Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis.
Bortezomib: new indication. Second-line treatment of myeloma: limited efficacy, major risks.
CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma.
Dll1/Notch activation contributes to bortezomib resistance by upregulating CYP1A1 in multiple myeloma.
Effect of cytochrome P450 3A4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or non-Hodgkin's lymphoma.
Effect of the Cytochrome P450 2C19 Inhibitor Omeprazole on the Pharmacokinetics and Safety Profile of Bortezomib in Patients with Advanced Solid Tumours, Non-Hodgkin's Lymphoma or Multiple Myeloma.
Influence of genetic polymorphisms in CYP3A4, CYP3A5, GSTP1, GSTM1, GSTT1 and MDR1 genes on survival and therapy-related toxicity in multiple myeloma.
Involvement of the arachidonic acid cytochrome P450 epoxygenase pathway in the proliferation and invasion of human multiple myeloma cells.
No influence of the polymorphisms CYP2C19 and CYP2D6 on the efficacy of cyclophosphamide, thalidomide, and bortezomib in patients with Multiple Myeloma.
Pharmacogenetics of medication-related osteonecrosis of the jaw: a systematic review and meta-analysis.
Rare naturally occurring immune responses to three epitopes from the widely expressed tumour antigens hTERT and CYP1B1 in multiple myeloma patients.
Multiple Sclerosis
Association between age at onset of multiple sclerosis and vitamin D level-related factors.
CYP27A1, CYP24A1, and RXR-? Polymorphisms, Vitamin D, and Multiple Sclerosis: a Pilot Study.
CYP4F Enzymes are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis.
Cytochrome P450 in neurological disease.
Enantioselectivity in the Metabolism of Cyclophosphamide in Patients With Multiple or Systemic Sclerosis.
Expression of CYP24A1 and other multiple sclerosis risk genes in peripheral blood indicates response to vitamin D in homeostatic and inflammatory conditions.
Frequency of CYP2D6 allelic variants in multiple sclerosis.
Genetic evidence for a pathogenic role for the vitamin D3 metabolizing enzyme CYP24A1 in multiple sclerosis.
Interferon-beta treatment in patients with multiple sclerosis does not alter CYP2C19 or CYP2D6 activity.
Multiple sclerosis and exposure to organic solvents, investigated by genetic polymorphisms of the GSTM1 and CYP2D6 enzyme systems.
Therapeutic protein-drug interaction assessment for daclizumab high-yield process in patients with multiple sclerosis using a cocktail approach.
VDR and CYP24A1 Expression Analysis in Iranian Relapsing-Remitting Multiple Sclerosis Patients.
[Association between vitamin D status and CYP27b1 and CYP24A1 gene polymorphisms in patients with multiple sclerosis in the Altai region].
[Association of vitamin D metabolism enzyme gene polymorphisms with multiple sclerosis risk: pilot study].
Multiple Sclerosis, Relapsing-Remitting
VDR and CYP24A1 Expression Analysis in Iranian Relapsing-Remitting Multiple Sclerosis Patients.
Multiple System Atrophy
A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism.
CYP2D6-debrisoquine hydroxylase gene polymorphism in multiple system atrophy.
Muscle Cramp
Increased brain vitamin D receptor expression and decreased expression of cathelicidin antimicrobial peptide in individuals who died by suicide.
Muscle Spasticity
Cholestenoic acids regulate motor neuron survival via liver X receptors.
Muscular Atrophy
Physiological, pharmacokinetic, and pharmacodynamic changes in space.
Muscular Diseases
A Pharmacogenomic Dissection of a Rosuvastatin-Induced Rhabdomyolysis Case Evokes the Polygenic Nature of Adverse Drug Reactions.
Clinical implications of pharmacogenetic variation on the effects of statins.
Colchicine: serious interactions.
Combination lipid-lowering therapy with statins: safety issues in the postcerivastatin era.
Critical illness myopathy, steroids, and cytochrome P450.
Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions.
Effect of thyroid hormone status and concomitant medication on statin induced adverse effects in hyperlipidemic patients.
HIV protease inhibitors and dyslipidemia.
HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles.
Impact of pharmacogenetics on statin-induced myopathy in South-Indian subjects.
Incidence of adverse events with HMG-CoA reductase inhibitors in liver transplant patients.
Liver and statins: a critical appraisal of the evidence.
Low myopathy rates associated with statins as monotherapy or combination therapy with interacting drugs in a group model health maintenance organization.
Major Cardiac-Psychiatric Drug-Drug Interactions: a Systematic Review of the Consistency of Drug Databases.
Pharmacological interactions of statins.
Rhabdomyolysis following clarithromycin monotherapy.
Risk management of simvastatin or atorvastatin interactions with CYP3A4 inhibitors.
Statin safety: an assessment using an administrative claims database.
STATIN-ASSOCIATED INTOLERANCE AND ITS PREVENTION.
Statin-associated myopathy.
The role of cytochrome P450-mediated drug-drug interactions in determining the safety of statins.
The role of mitochondria in statin-induced myopathy.
The SLCO1B1*5 Genetic Variant Is Associated With Statin-Induced Side Effects.
[Fibrate and statine myopathy]
[Pharmacogenomics in routine medical care]
Myalgia
Incidence of adverse events with HMG-CoA reductase inhibitors in liver transplant patients.
Late response to rosuvastatin and statin-related myalgia due to SLCO1B1, SLCO1B3, ABCB11, and CYP3A5 variants in a patient with Familial Hypercholesterolemia: a case report.
Myasthenia Gravis
Dose optimisation of tacrolimus with therapeutic drug monitoring and CYP3A5 polymorphism in myasthenia gravis patients.
Mycetoma
Polymorphisms in catechol-O-methyltransferase and cytochrome p450 subfamily 19 genes predispose towards Madurella mycetomatis-induced mycetoma susceptibility.
Mycoplasma Infections
Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6.
Mycoses
Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus.
Host-induced gene silencing of cytochrome P450 lanosterol C14?-demethylase-encoding genes confers strong resistance to Fusarium species.
In Silico Structural Modeling and Analysis of Interactions of Tremellomycetes Cytochrome P450 Monooxygenases CYP51s with Substrates and Azoles.
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF.
Resistance to Fusarium Head Blight and Seedling Blight in Wheat Is Associated with Activation of a Cytochrome P450 Gene
Resistance to Fusarium head blight and seedling blight in wheat is associated with activation of a cytochrome p450 gene.
Voriconazole-induced Severe Hyperkalemia Precipitated by Multiple Drug Interactions.
Mydriasis
Two separate dose-dependent effects of paroxetine: mydriasis and inhibition of tramadol's O-demethylation via CYP2D6.
Myelodysplastic Syndromes
CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility.
Myocardial Infarction
A population-based study of the drug interaction between proton pump inhibitors and clopidogrel.
Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction.
Aripiprazole-induced atrial fibrillation in a patient with concomitant risk factors.
Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population.
Cigarette smoking might weaken the prognostic significance of cytochrome P450 2C19*2 polymorphism in acute myocardial infarction patients.
Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) registry.
Coffee, CYP1A2 genotype and risk of myocardial infarction.
Coffee, CYP1A2 genotype, and risk of myocardial infarction.
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
CYP1A2 polymorphism (C > A at position -163) in Ovambos, Koreans and Mongolians.
CYP2D6 is a major determinant of metoprolol disposition and effects in hospitalized Russian patients treated for acute myocardial infarction.
Cytochrome p450 2C enzymes contribute to peritransplant ischemic injury and cardiac allograft vasculopathy.
Cytochrome p450 2C inhibition reduces post-ischemic vascular dysfunction.
Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study.
Cytochrome P450 2C19 Polymorphism, Suboptimal Reperfusion and All-Cause Mortality in Patients with Acute Myocardial Infarction.
Cytochrome p450 gene variants, race, and mortality among clopidogrel-treated patients after acute myocardial infarction.
Cytochrome P450: another player in the myocardial infarction game?
Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction.
Genetic variance in CYP2C8 and increased risk of myocardial infarction.
Genetic variation, ?-blockers, and perioperative myocardial infarction.
Impact of CYP2C8 and 2C9 polymorphisms on coronary artery disease and myocardial infarction in the LURIC cohort.
Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction - a prospective observational study.
Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel.
Influences of Smoking Status on Effectiveness of Cytochrome P450 Enzyme System Metabolized Medications in Reducing In-Hospital Death in 14 658 Patients With Acute Myocardial Infarction: Data From CPACS-3 Study.
Inhibition of cardiac cytochrome P450: a new approach to cardiac ischaemia and reperfusion damage.
Letter by Hnid and Chtioui regarding article, "Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Registry".
Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases.
Myocardial infarction following the combined recreational use of Viagra and cannabis.
Platelet inhibition by adjunctive cilostazol versus high maintenance-dose clopidogrel in patients with acute myocardial infarction according to cytochrome P450 2C19 genotype.
Significance of L-carnitine in internal medicine.
Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa.
Sulfaphenazole protects heart against ischemia-reperfusion injury and cardiac dysfunction by overexpression of iNOS leading to enhancement of nitric-oxide bioavailability and tissue oxygenation.
Switching from prasugrel to clopidogrel based on Cytochrome P450 2C19 genotyping in East Asian patients stabilized after acute myocardial infarction.
Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction.
The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9.
Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction.
[Association of CYP2C19 and CYP3A5 gene polymorphisms with myocardial infarction].
Myocardial Ischemia
Cytochrome 2C19 and paraoxonase-1 polymorphisms and clopidogrel resistance in ischemic heart disease patients.
Cytochrome p450 2C (CYP2C) in ischemic heart injury and vascular dysfunction.
Cytochrome P450 and ischemic heart disease: current concepts and future directions.
Cytochrome P450 and myocardial ischemia: potential pharmacological implication for cardioprotection.
Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice.
The relationship between plasma concentration of metoprolol and CYP2D6 genotype in patients with ischemic heart disease.
Myocardial Reperfusion Injury
Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity.
Myocardial Stunning
Cytochrome P450-2D6 Genotype Definition May Improve Therapy for Paroxysmal Atrial Fibrillation A Case of Syncope Following "Pill-in-the-Pocket" Quinidine plus Propafenone.
Myocarditis
Proteomics analyses for the global proteins in the brain tissues of different human prion diseases.
Myoclonus
Clozapine pharmacokinetics and pharmacodynamics studied with Cyp1A2-null mice.
Myoclonus After Dextromethorphan Administration in Peritoneal Dialysis (January) (FREE).
Seizures and myoclonus associated with antidepressant treatment: assessment of potential risk factors, including CYP2D6 and CYP2C19 polymorphisms, and treatment with CYP2D6 inhibitors.
Myoma
Aromatase expression in the eutopic endometrium of myomatous uteri: the influence of the menstrual cycle and oral contraceptive use.
Protein Expression of Estrogen Receptors ? and ? and Aromatase in Myometrium and Uterine Leiomyoma.
Relationship between aromatase activity and steroid receptor levels in ovarian tumors from postmenopausal women.
[Association of polymorph variants of CYP1A2 and CYP1A1 genes with reproductive and thyroid diseases in female workers of petrochemical industry].
Myotonic Dystrophy
Linkage relationships of the apolipoprotein C1 gene and a cytochrome P450 gene (CYP2A) to myotonic dystrophy.
Myotoxicity
Alcohol-associated rhabdomyolysis: ethanol induction of cytochrome P450 may potentiate myotoxicity.
Cerivastatin in vitro metabolism by CYP2C8 variants found in patients experiencing rhabdomyolysis.
Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance.
Enantiospecific Pharmacogenomics of Fluvastatin.
Severe Rhabdomyolysis due to Presumed Drug Interactions between Atorvastatin with Amlodipine and Ticagrelor.
Statin-Induced Myotoxicity: Pharmacokinetic Differences among Statins and the Risk of Rhabdomyolysis, with Particular Reference to Pitavastatin.
nadph-hemoprotein reductase deficiency
Mutations of human cytochrome P450 reductase differentially modulate heme oxygenase-1 activity and oligomerization.
P450 oxidoreductase deficiency: a new disorder of steroidogenesis affecting all microsomal P450 enzymes.
P450 Oxidoreductase deficiency: Analysis of mutations and polymorphisms.
Reply to Flück et al.: Alternative androgen pathway biosynthesis drives fetal female virilization in P450 oxidoreductase deficiency.
Nasal Polyps
The expression of 11?-hydroxysteroid dehydrogenase type 1 and 2 in nasal polyp-derived epithelial cells and its possible contribution to glucocorticoid activation in nasal polyp.
Nasopharyngeal Carcinoma
A Case-Control and a Family-Based Association Study Revealing an Association between CYP2E1 Polymorphisms and Nasopharyngeal Carcinoma Risk in Cantonese.
Childhood nasopharyngeal carcinoma: from biology to treatment.
CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan.
CYP2E1 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis.
Cytochrome P450 2A6 polymorphism in nasopharyngeal carcinoma.
Cytochrome P450 2E1 polymorphism and nasopharyngeal carcinoma development in Thailand: a correlative study.
Expression of CYP2E1 in human nasopharynx and its metabolic effect in vitro.
Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China.
Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC1 and hOGG1.
No association between genetic polymorphisms of CYP1A1, GSTM1, GSTT1, GSTP1, NAT2, and nasopharyngeal carcinoma in Taiwan.
Polymorphisms of CYP2E1 rs2031920 is not Associated with Risk of Nasopharyngeal Carcinoma in Minangkabau Ethnic Group.
The association between gene polymorphisms and risk of nasopharyngeal carcinoma.
The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients.
[Association of nasopharyngeal carcinoma risk with cytochrome P450 CYP1A1 gene polymorphisms]
[Cloning and sequence analysis of human embryonic nasopharyngeal epithelial CYP2E1 cDNA]
[Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue]
Nasopharyngeal Neoplasms
Association of nasopharyngeal cancer risk with genetic polymorphisms of drug-metabolizing enzyme genes GSTM1, GSTT1 and CYP1A1 (rs4646903 variant), in tobacco addicted patients of Pashtun ethnicity of Khyber Pakhtunkhwa Province of Pakistan.
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
The polymorphism of CYP2E1 Rsa I/Pst I gene and susceptibility to respiratory system cancer: a systematic review and meta-analysis of 34 studies.
[Expression of human cytochrome P450 2E1 gene in embryonic nasopharynx, nasopharyngeal cancer cell lines and tissue]
[Stable expression of human cytochrome P450 2E1 cDNA in nasopharyngeal cancer cell line CNE-2]
Neonatal Abstinence Syndrome
Variations in Infant CYP2B6 Genotype Associated with the Need for Pharmacological Treatment for Neonatal Abstinence Syndrome in Infants of Methadone-Maintained Opioid-Dependent Mothers.
Neoplasm Metastasis
27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression.
A case of renin-producing adrenocortical cancer.
ABCB1 and ABCC2 and the risk of distant metastasis in Thai breast cancer patients treated with tamoxifen.
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.
Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population.
Attenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): From bench to clinic.
Cancer Activation and Polymorphisms of Human Cytochrome P450 1B1.
Chromosomal region 15q21.1 is a frequent target of allelic imbalance in advanced breast carcinomas.
CXCR4 is involved in CD133-induced EMT in non-small cell lung cancer.
CYP genes in osteosarcoma: Their role in tumorigenesis, pulmonary metastatic microenvironment and treatment response.
CYP1B1 Enhances Cell Proliferation and Metastasis through Induction of EMT and Activation of Wnt/?-Catenin Signaling via Sp1 Upregulation.
CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.
CYP24A1 is a potential biomarker for the progression and prognosis of human colorectal cancer.
CYP27A1 and CYP24 expression as a function of malignant transformation in the colon.
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer.
CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling.
CYP3A5 suppresses metastasis of lung adenocarcinoma through ATOH8/Smad1 axis.
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis.
Cytochrome P450 1A1 (CYP1A1) polymorphism and susceptibility to esophageal cancer: an updated meta-analysis of 27 studies.
Cytochrome P450 2A6 is associated with macrophage polarization and is a potential biomarker for hepatocellular carcinoma.
Cytochrome P450 ?-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer.
Cytochrome P450 content in primary tumors and liver metastases of patients with metastatic colorectal cancer.
Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma.
Cytochrome p450 epoxygenase promotes human cancer metastasis.
Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China.
Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion.
Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma.
Effects of ellagic Acid on angiogenic factors in prostate cancer cells.
Erlotinib-induced Hepatotoxicity-Clinical Presentation and Successful Management: A Case Report.
Gene Expression of CYP1A1 and its Possible Clinical Application in Thyroid Cancer Cases.
GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.
Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis.
Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation.
Hypomethylation of the XRE -1383 site is associated with the upregulation of CYP1A1 in gastric adenocarcinoma.
Identification of co-expression modules and pathways correlated with osteosarcoma and its metastasis.
Identification of cytochrome P450 enzymes in human colorectal metastases and the surrounding liver: a proteomic approach.
Impact of IGF-I and CYP19 gene polymorphisms on the survival of patients with metastatic prostate cancer.
Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-?-catenin signalling, the stem cell phenotype and disease progression.
Micro1278 Leads to Tumor Growth Arrest, Enhanced Sensitivity to Oxaliplatin and Vitamin D and Inhibits Metastasis via KIF5B, CYP24A1, and BTG2, Respectively.
MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1.
miR-30a promoter variation contributes to the increased risk of colorectal cancer in an Iranian population.
N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine (DPPE; tesmilifene), a chemopotentiating agent with hormetic effects on DNA synthesis in vitro, may improve survival in patients with metastatic breast cancer.
No effect of thromboxane A2 on the attachment of tumor cell lines MDA MB 231, DU145, and U937 to the basement membrane in an in-vitro model.
On the relationship between VDR, ROR? and ROR? receptors expression and HIF1-? levels in human melanomas.
Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.
Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
Prediction of Early Recurrence After Curative Resection of Colorectal Liver Metastasis and Subsequent S-1 Chemotherapy.
Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers.
Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.
Relationship between CYP1A1 polymorphisms and invasion and metastasis of breast cancer.
Self-packed core shell nano liquid chromatography columns and silica-based monolithic trap columns for targeted proteomics.
Silencing TAK1 alters gene expression signatures in bladder cancer cells.
Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6.
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.
The Consequences of Soluble Epoxide Hydrolase Deletion on Tumorigenesis and Metastasis in a Mouse Model of Breast Cancer.
The Pathogenic Effects of Fusobacterium nucleatum on the Proliferation, Osteogenic Differentiation, and Transcriptome of Osteoblasts.
The prognostic values of CYP2B6 genetic polymorphisms and metastatic sites for advanced breast cancer patients treated with docetaxel and thiotepa.
The role of aromatase and 17-beta-hydroxysteroid dehydrogenase type 1 mRNA expression in predicting the clinical outcome of human breast cancer.
Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung.
Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer.
[Study on the Difference of Gene Expression between Central and Peripheral Lung Squamous Cell Carcinoma Based on TCGA Database].
Neoplasms
(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent.
1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression.
20-HETE-producing enzymes are up-regulated in human cancers.
24-Hydroxylase in cancer: Impact on vitamin D-based anticancer therapeutics.
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.
7 in vitro methods for evaluation of p450-based anticancer gene therapy.
7,12-Dimethylbenz[a]anthracene inhibition of steroid production in MA-10 mouse Leydig tumor cells is not directly linked to induction of CYP1B1.
7-ethoxyresorufin O-deethylase (EROD) activity is not capable of reflecting the overall malignant potential of breast cancer tissue.
8 tumor models for evaluation of p450 gene therapy in vivo.
CYP2A6 and CYP2E1 polymorphisms in a Brazilian population living in Rio de Janeiro.
?-3 Polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice.
?-3 Polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer.
A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors.
A clinical investigation of inhibitory effect of panobinostat on CYP2D6 substrate in patients with advanced cancer.
A clinical protocol for treatment of canine mammary tumors using encapsulated, cytochrome P450 synthesizing cells activating cyclophosphamide: a phase I/II study.
A Combined Molecular Docking/Dynamics Approach to Probe the Binding Mode of Cancer Drugs with Cytochrome P450 3A4.
A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption.
A comparative study of hepatic and colonic metabolic enzymes in inbred mouse lines before and after treatment with the colon carcinogen, 1,2-dimethylhydrazine.
A comparison between lung carcinoma and a subcutaneous malignant tumor induced in rats by a 3,4-benzopyrene injection.
A comparison of the pharmacokinetics and pharmacodynamics of docetaxel between African-American and Caucasian cancer patients: CALGB 9871.
A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.
A comprehensive review of cytochrome P450 2E1 for xenobiotic metabolism.
A constitutive deficiency in the monooxygenase system of spontaneous mouse liver tumors.
A cytochrome P450 2B6 meditated gene therapy strategy to enhance the effects of radiation or cyclophosphamide when combined with the bioreductive drug AQ4N.
A discordance of the cytochrome P450 2C19 genotype and phenotype in patients with advanced cancer.
A drug-drug interaction study to assess the effect of the CYP1A2 inhibitor fluvoxamine on the pharmacokinetics of dovitinib (TKI258) in patients with advanced solid tumors.
A high throughput screening assay to screen for CYP2E1 metabolism and inhibition using a fluorogenic vivid p450 substrate.
A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction.
A hydroxylated flavonol, fisetin inhibits the formation of a carcinogenic estrogen metabolite.
A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2.
A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.
A method for assaying aryl hydrocarbon hydroxylase in man using fibroblasts cultured in vitro from oral mucosa.
A mode of action for induction of liver tumors by Pyrethrins in the rat.
A new opportunity for nanomedicines: Micellar cytochrome P450 inhibitors to improve drug efficacy in a cancer therapy model.
A new role for tamoxifen in oestrogen receptor-negative breast cancer when it is combined with epigallocatechin gallate.
A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis.
A novel methodology for enhanced and consistent heterologous expression of unmodified human cytochrome P450 1B1 (CYP1B1).
A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur.
A phase II study of perioperative S-1 combined with weekly docetaxel in patients with locally advanced gastric carcinoma: clinical outcomes and clinicopathological and pharmacogenetic predictors for survival.
A possible modulatory influence of melatonin on representative phase I and II drug metabolizing enzymes in 9,10-dimethyl-1,2-benzanthracene induced rat mammary tumorigenesis.
A possible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cells and tumor tissues.
A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis.
A regulatory variant in CYP2E1 affects the risk of lung squamous cell carcinoma.
A Reversed-Phase Mode LC-MS/MS Method Using a Polysaccharide Chiral Selector for Simultaneous Quantitation of Each Enantiomer of Tramadol and its Metabolites in Human Plasma and Evaluation of CYP-Mediated Stereoselective Demethylation.
A review of gene-drug interactions for nonsteroidal anti-inflammatory drug use in preventing colorectal neoplasia.
A risk assessment of atrazine use in California: human health and ecological aspects.
A Simulation Study to Compare the Treatment Effect of Tamoxifen by CYP2D6 Genotypes and Third-Generation Aromatase Inhibitors.
A steroidogenic factor-1-binding site and cyclic adenosine 3',5'-monophosphate response element-like elements are required for the activity of the rat aromatase promoter in rat Leydig tumor cell lines.
A systematic review on hepatoprotective activity of quercetin against various drugs and toxic agents: Evidence from preclinical studies.
A virus-directed enzyme prodrug therapy (VDEPT) strategy for lung cancer using a CYP2B6/NADPH-cytochrome P450 reductase fusion protein.
Abemaciclib Does Not Have a Clinically Meaningful Effect on Pharmacokinetics of CYP1A2, CYP2C9, CYP2D6, and CYP3A4 Substrates in Patients with Cancer.
Abiraterone and Ionizing Radiation Alter the Sphingolipid Homeostasis in Prostate Cancer Cells.
Absence of a differential induction of cytochrome P450 2E1 by different alcoholic beverages in rats: implications for the aetiology of human oesophageal cancer.
ACTH-receptor expression, regulation and role in adrenocortial tumor formation.
Activating Mutations of ESR1, BRCA1 and CYP19 Aromatase Genes Confer Tumor Response in Breast Cancers Treated with Antiestrogens.
Activation of aflatoxin B1 by expression of human CYP1A2 polymorphisms in Saccharomyces cerevisiae.
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.
Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function.
Activation of oxazaphosphorines by cytochrome P450: Application to gene-directed enzyme prodrug therapy for cancer.
Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells.
Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes.
Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2.
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.
Activation of thio-tepa cytotoxicity toward human breast-cancer cells by hepatic cytochrome-p450.
Adductomic signatures of benzene exposure provide insights into cancer induction.
Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+.
Adenovirus-mediated targeted gene therapy for breast cancer and for purging hematopoietic stem-cell sources.
Adrenocortical-pituitary hybrid tumor causing Cushing's syndrome.
Adult granulosa cell tumors of the ovary: a retrospective study of 30 cases with respect to the expression of steroid synthesis enzymes.
Advances in methods for predicting phase I metabolism of polyphenols.
Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.
Alcohol and cancer: an overview with special emphasis on the role of acetaldehyde and cytochrome P450 2E1.
Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer.
Alcohol Induces Liver Neoplasia in a Novel Alcohol-Preferring Rat Model.
Alcohol oxidizing enzymes and ethanol-induced cytotoxicity in rat pancreatic acinar AR42J cells.
Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis.
Aldosterone-producing adrenocortical carcinoma with prominent hepatic metastasis diagnosed by liver biopsy: a case report.
Alleles of polymorphic sites that correspond to hyperactive variants of CYP1B1 protein are significantly less frequent in Japanese as compared to American and German populations.
Allelic variations in CYP2D6 gene and susceptibility to cervical cancer.
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
Alteration of the Risk of Oral Pre-Cancer and Cancer in North India Population by CYP1A1 Polymorphism Genotypes and Haplotype
Alteration of xenobiotic metabolizing enzymes by resveratrol in liver and lung of CD1 mice.
Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice.
Alterations in ubiquitin ligase Siah-2 and its corepressor N-CoR after P-MAPA immunotherapy and anti-androgen therapy: new therapeutic opportunities for non-muscle invasive bladder cancer.
Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation.
Altered expression of cytochrome P450 enzymes involved in metabolism of androgens and vitamin D in the prostate as a risk factor for prostate cancer.
Altered expression of cytochrome P450 mRNA during chemical-induced hepatocarcinogenesis and following partial hepatectomy.
Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages.
An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice.
An evaluation of the drug interaction potential of pazopanib, an oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, using a modified cooperstown 5+1 cocktail in patients with advanced solid tumors.
An Excess of CYP24A1, Lack of CaSR, and a Novel lncRNA Near the PTH Gene Characterize an Ectopic PTH-Producing Tumor.
An Open-Label Study to Assess the Effect of Itraconazole and Rifampin on Parsaclisib Pharmacokinetics When Administered Orally in Healthy Participants.
An original administration of ifosfamide given once every other week: a clinical and pharmacological study.
An update on drug-drug interactions with biologics for the treatment of moderate-to-severe psoriasis.
Analysis of ?-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital.
Analysis of CYP2D6 expression in human lung: implications for the association between CYP2D6 activity and susceptibility to lung cancer.
Analysis of CYP450 gene allelic variants can predict ifosfamide toxicity in Mexican paediatric patients.
Analysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer.
Analysis of point mutation in exon 2 of CYP2E1 gene in renal cell/urothelial cancer patients in comparison with control population.
Analysis of RNA from brush cytology detects changes in B2M, CYP1B1 and KRT17 levels with OSCC in tobacco users.
Analysis of the aromatase cytochrome P450 gene in human breast cancers.
Analyzing the differentially expressed genes and pathway cross-talk in aggressive breast cancer.
Androgen receptor overexpression in prostate cancer in type 2 diabetes.
Androgens inhibit aromatase expression through DAX-1: insights into the molecular link between hormone balance and Leydig cancer development.
ANNALS EXPRESS: Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients.
Anti-Colorectal Cancer Mechanisms of Formononetin Identified by Network Pharmacological Approach.
Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.
Anti-tumor activities of lipids and lipid analogues and their development as potential anticancer drugs.
Antiangiogenesis enhances intratumoral drug retention.
Anticancer activity of litchi fruit pericarp extract against human breast cancer in vitro and in vivo.
Antimutagenic Effects of Selenium-Enriched Polysaccharides from Pyracantha fortuneana through Suppression of Cytochrome P450 1A Subfamily in the Mouse Liver.
Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice.
Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats.
Antiproliferative and antioxidant potential of beta-ionone against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism.
Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines.
Antitumor activity of methoxymorpholinyl doxorubicin: potentiation by cytochrome P450 3A metabolism.
Antitumour prodrug development using cytochrome P450 (CYP) mediated activation.
Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPAR?-mediated lipogenic gene expression.
Application of Homolgy Modeling to Generate CYP1A1 Mutants with Enhanced Activation of the Cancer Chemotherapeutic Prodrug Dacarbazine.
Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration.
Aromatase (CYP19) promoter gene polymorphism and risk of nonviral hepatitis-related hepatocellular carcinoma.
Aromatase Acetylation Patterns and Altered Activity in Response to Sirtuin Inhibition.
Aromatase activity and CYP19 gene expression in breast cancers.
Aromatase activity induction in human adipose fibroblasts by retinoic acids via retinoic acid receptor ?.
Aromatase and comparative response to its inhibitors in two types of endometrial cancer.
Aromatase cytochrome P450 and estrogen and progesterone receptors in uterine sarcomas: correlation with clinical parameters.
Aromatase cytochrome P450 enzyme expression in prolactinomas and its relationship to tumor behavior.
Aromatase expression in endometriosis.
Aromatase expression in ovarian epithelial cancers.
Aromatase inhibition and experimental antitumor activity of FCE 24304, MDL 18962 and SH 489.
Aromatase inhibitors and the treatment of breast cancer.
Aromatase inhibitors and their potential clinical significance.
Aromatic DNA adducts in coke-oven workers, in relation to exposure, lifestyle and genetic polymorphism of metabolic enzymes.
Aryl hydrocarbon hydroxylase activity in chemically induced and toremifene-treated mammary tumors in rats.
Aryl hydrocarbon hydroxylase activity in human lung tissue: in relation to cigarette smoking and lung cancer.
Aryl hydrocarbon hydroxylase activity in mouse, rat, and human mammary tumors.
Aryl hydrocarbon hydroxylase activity in pulmonary alveolar macrophages and lymphocytes from lung cancer and noncancer patients: a correlation with family histories of cancer.
Aryl hydrocarbon hydroxylase activity in pulmonary macrophages and blood lymphocytes. Asbestos-exposed cigarette smokers with and without lung cancer.
Aryl hydrocarbon hydroxylase activity in spontaneous mammary tumors in rat.
Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls.
Aryl hydrocarbon hydroxylase inducibility among primary relatives of children with leukemia or solid tumors.
Aryl hydrocarbon hydroxylase induction levels in patients with malignant tumors associated with smoking.
Aryl hydrocarbon receptor plays a significant role in mediating airborne particulate-induced carcinogenesis in mice.
Aryl hydrocarbon receptor-dependent cell cycle arrest in isolated mouse oval cells.
Aryl morpholino triazenes inhibit cytochrome P450 1A1 and 1B1.
Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice.
Assessment of cancer susceptibility in humans by use of genetic polymorphisms in carcinogen metabolism.
Assessment of effects of repeated oral doses of fedratinib on inhibition of cytochrome P450 activities in patients with solid tumors using a cocktail approach.
Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo.
Assessment of the drug interaction potential and single- and repeat-dose pharmacokinetics of the BRAF inhibitor dabrafenib.
Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-analyses including 2164 cases and 4160 controls.
Association between CYP2C8 (rs1934951) Polymorphism and Bisphosphonate-Related Osteonecrosis of the Jaws in Patients on Bisphosphonate Therapy: A Meta-Analysis.
Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.
Association between CYP2E1 genetic polymorphisms and urinary cancer risk: a meta-analysis.
Association between early-onset breast and laryngeal cancers.
Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma.
Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan.
Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms.
Association between telomere length and CYP19 TTTA repetition polymorphism in healthy and breast cancer-diagnosed women.
Association between the CYP1A1 A2455G polymorphism and risk of cancer: evidence from 272 case-control studies.
Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies.
Association between the CYP1A2 polymorphisms and risk of cancer: a meta-analysis.
Association between the CYP1B1 polymorphisms and risk of cancer: a meta-analysis.
Association between the CYP3A4 and CYP3A5 polymorphisms and cancer risk: a meta-analysis and meta-regression.
Association of a novel seven-gene expression signature with the disease prognosis in colon cancer patients.
Association of ABCB1, 5-HT3B Receptor and CYP2D6 Genetic Polymorphisms with Ondansetron and Metoclopramide Antiemetic Response in Indonesian Cancer Patients Treated with Highly Emetogenic Chemotherapy.
Association of aryl hydrocarbon receptor and cytochrome P4501B1 expressions in human non-small cell lung cancers.
Association of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors.
Association of CYP1A1 A4889G and T6235C polymorphisms with the risk of sporadic breast cancer in Brazilian women.
Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone.
Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue.
Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer.
Association of CYP1B1 L432V polymorphism with urinary cancer susceptibility: a meta-analysis.
Association of CYP24A1 gene polymorphism with colorectal cancer in the Jiamusi population.
Association of CYP2A6 gene deletion with cancers in Japanese elderly: an autopsy study.
Association of CYP2A6 gene deletion with cigarette smoking status in Japanese adults.
Association of CYP2C19*3 gene polymorphism with breast cancer in Chinese women.
Association of CYP2D6 genotype and tamoxifen metabolites with breast cancer recurrence in a low-dose trial.
Association of CYP2E1 gene polymorphism with predisposition to cancer development.
Association of CYP3A4/5 genotypes and expression with the survival of patients with neuroblastoma.
Association of CYP3A5 Expression and Vincristine Neurotoxicity in Pediatric Malignancies in Turkish Population.
Association of Cytochrome CYP1A1 Gene Polymorphisms and Tobacco Smoking With the Risk of Breast Cancer in Women From Iraq.
Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus.
Association of cytochrome P450 2E1 polymorphisms and head and neck squamous cell cancer.
Association of genetic polymorphisms in CYP19 and CYP1A1 with the oestrogen receptor-positive breast cancer risk.
Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women.
Association of Genetic Variants of CYP2C19 and CYP2D6 with Esophageal Squamous Cell Carcinoma Risk in Northern India, Kashmir.
Association of The Common CYP1A1*2C Variant (Ile462Val Polymorphism) with Chronic Myeloid Leukemia (CML) in Patients Undergoing Imatinib Therapy.
Association of the CYP1A1 MspI and TNF?-308 polymorphisms with chronic obstructive pulmonary disease in Inner Mongolia.
Association of the CYP1B1 Leu432Val polymorphism with the risk of prostate cancer: a meta-analysis.
Association of the CYP24A1-rs2296241 polymorphism of the vitamin D catabolism enzyme with hormone-related cancer risk: a meta-analysis.
Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses.
Association study between CYP24A1 gene polymorphisms and cancer risk.
Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population.
Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race.
Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients.
Associations of Biomarkers of Inflammation and Breast Cancer in the Breast Adipose Tissue of Women with Combined Measures of Adiposity.
Atezolizumab plus bevacizumab combination enables an unresectable hepatocellular carcinoma resectable and links immune exclusion and tumor dedifferentiation to acquired resistance.
Attenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): From bench to clinic.
Axyl hydrocarbon hydroxylase in Morris hepatoma 5123D.
Baculovirus P35 protein: An overview of its applications across multiple therapeutic and biotechnological arenas.
Basal cell carcinomas: association of allelic variants with a high-risk subgroup of patients with the multiple presentation phenotype.
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.
Benzo[a]pyrene-dependent activation of transcription factors NF-kappaB and AP-1 related to tumor promotion in hepatoma cell cultures.
Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
Biliary excretion of imatinib mesylate and its metabolite CGP 74588 in humans.
Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells.
Bioavailability of tyrosine kinase inhibitors: an added component of assessment.
Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats.
Biochemical characterization of in vivo alkylating agent resistance of a murine EMT-6 mammary carcinoma. Implication for systemic involvement in the resistance phenotype.
Biochemistry and enzyme induction in MC-29 virus-induced transplantable avian hepatoma.
Biologic markers in cancer diagnosis and treatment.
Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B1.
Biomarkers of susceptibility and effect in car painters exposed to organic solvents.
Biomonitoring of exposure to urban air pollutants: analysis of sister chromatid exchanges and DNA lesions in peripheral lymphocytes of traffic policemen.
Black tea polyphenols modulate xenobiotic-metabolizing enzymes, oxidative stress and adduct formation in a rat hepatocarcinogenesis model.
Boschniakia rossica prevents the carbon tetrachloride-induced hepatotoxicity in rat.
Breast cancer risk associated with CYP1A1 genetic polymorphisms in Japanese women.
Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility.
Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes.
Caffeine Cytochrome P450 1A2 Metabolic Phenotype Does Not Predict the Metabolism of Heterocyclic Aromatic Amines in Humans.
Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide.
cAMP-dependent transactivation involving the homeodomain protein Pbx1.
Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor.
Can CYP Inhibition Overcome Chemotherapy Resistance?
Can CYP1A1 siRNA be an effective treatment for lung cancer?
Cancer Activation and Polymorphisms of Human Cytochrome P450 1B1.
Cancer cachexia raises the plasma concentration of oxymorphone through the reduction of CYP3A but not CYP2D6 in oxycodone-treated patients.
Cancer chemoprevention revisited: Cytochrome P450 family 1B1 as a target in the tumor and the microenvironment.
Cancer chemopreventive and anti-inflammatory activities of chemically modified guar gum.
Cancer Chemopreventive Properties of Sulfated Enterolobium cyclocarpum Extract.
Cancer stem cells and nanomedicine: new opportunities to combat multidrug resistance?
Cancer therapy and polymorphisms of cytochromes P450.
Cancer treatment and pharmacogenetics of cytochrome P450 enzymes.
Cancer, inflammation, and therapy: effects on cytochrome p450-mediated drug metabolism and implications for novel immunotherapeutic agents.
Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN.
Cannabis and anticancer drugs: societal usage and expected pharmacological interactions - a review.
Carcinogen activation by human uterine enzymes.
Carcinogen Metabolism Pathway and Tumor Suppressor Gene Polymorphisms and Gallbladder Cancer Risk in North Indians: A Hospital-Based Case-Control Study.
Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2.
Carvedilol serves as a novel CYP1B1 inhibitor, a systematic drug repurposing approach through structure-based virtual screening and experimental verification.
Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes.
Celery extract inhibits mouse CYP2A5 and human CYP2A6 activities via different mechanisms.
Cellular levels of class 1 and class 3 aldehyde dehydrogenases and certain other drug-metabolizing enzymes in human breast malignancies.
Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer.
Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.
Characteristic CYP2A6 genetic polymorphisms detected by TA cloning-based sequencing in Chinese digestive system cancer patients with S-1 based chemotherapy.
Characterization and functional analysis of two common human cytochrome P450 1B1 variants.
Characterization and prevalence of a polymorphism in the 3' untranslated region of cytochrome P4501A1 in cancer-prone Atlantic tomcod.
Characterization of a human cell clone expressing cytochrome P450 for safe use in human somatic cell therapy.
Characterization of a single peptide derived from cytochrome P450 1B1 that elicits spontaneous human leukocyte antigen (HLA)-A1 as well as HLA-B35 restricted CD8 T-cell responses in cancer patients.
Characterization of common CYP1B1 variants with different capacity for benzo[a]pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene.
Characterization of differences in substrate specificity among CYP1A1, CYP1A2 and CYP1B1: an integrated approach employing molecular docking and molecular dynamics simulations.
Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution LC-MS, and quantitative HPLC analysis.
Chemomodulatory effects of Azadirachta indica on the hepatic status of skin tumor bearing mice.
Chemoprevention by Isothiocyanates: Molecular Basis of Apoptosis Induction.
Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice.
Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model.
Chemopreventive potential of dietary bioflavonoids against 20-methylcholanthrene-induced tumorigenesis.
Chemopreventive task of capsaicin against benzo(a)pyrene-induced lung cancer in Swiss albino mice.
Chemoresistance in Malignant Intracranial Tumors: Longer Survival with Negative MDR1 Expression.
Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53.
Chronic moderate ethanol intake differentially regulates vitamin D hydroxylases gene expression in kidneys and xenografted breast cancer cells in female mice.
Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1.
Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-?, and ER?: results from the EPIC-Heidelberg cohort.
Clinical effects of A4889G and T6235C polymorphisms in cytochrome P-450 CYP1A1 for breast cancer patients treated with tamoxifen: implications for tumor aggressiveness and patient survival.
Clinical implications of CYP2D6 genotyping in tamoxifen treatment for breast cancer.
Clinical pharmacokinetics of tyrosine kinase inhibitors: focus on 4-anilinoquinazolines.
Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.
Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue.
Cloning and sequence analysis of the cDNA encoding P-450 aromatase (P450arom) from a rainbow trout (Oncorhynchus mykiss) ovary; relationship between the amount of P450arom mRNA and the production of oestradiol-17 beta in the ovary.
Co-administration of obeticholic acid and simvastatin protects against high-fat diet-induced non-alcoholic steatohepatitis in mice.
Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status.
Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment.
Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins.
Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells.
Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy.
Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study.
Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer.
Combined effects of gender, skin type and polymorphic genes on clinical phenotype: use of rate of increase in numbers of basal cell carcinomas as a model system.
Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility.
Combined treatment with specific ligands for PPARgamma:RXR nuclear receptor system markedly inhibits the expression of cytochrome P450arom in human granulosa cancer cells.
Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia.
Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.
Comparative Expression Analysis of Cytochrome P450 1A1, Cytochrome P450 1B1 and Nuclear Receptors in the Female Genital and Colorectal Tissues of Human and Pigtailed Macaque.
Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines.
Comparative proteomics among cytochrome p450 family 1 for differential substrate specificity.
Comparative untargeted proteomic analysis of ADME proteins and tumor antigens for tumor cell lines.
Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes.
Comparison of the hepatic and renal effects of 1,4-dichlorobenzene in the rat and mouse.
Comparison of the pharmacokinetics and pharmacodynamics of S-1 between Caucasian and East Asian patients.
Comparison of the polymorphic regions of the cytochrome P450 CYP2E1 gene of humans and patas and cynomolgus monkeys.
Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues.
Complementarity of genotoxic and nongenotoxic predictors of rodent carcinogenicity.
Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy.
Computational identification and binding analysis of orphan human cytochrome P450 4X1 enzyme with substrates.
Concomitance of oncogenic HPV types, CHEK2 gene mutations, and CYP1B1 gene polymorphism as an increased risk factor for malignancy.
Concordance Between CYP2D6 Genotypes Obtained From Tumor-Derived and Germline DNA.
Concurrent hypercortisolism and hyperaldosteronism due to an adrenal adenoma.
Constitutive and inducible expression of cytochromes P4501A (CYP1A1 and CYP1A2) in normal prostate and prostate cancer cells.
Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ER?-negative breast tumorigenesis.
Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue.
Construction of p450-expressing tumor cell lines using retroviruses.
Contribution of ABCB1 and CYP2D6 genotypes to the outcome of tamoxifen adjuvant treatment in premenopausal women with breast cancer.
Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors.
Copper-mediated oxidative DNA damage induced by eugenol: possible involvement of O-demethylation.
Correlation of polymorphic expression of CYP2D6 mRNA in bladder mucosa and tumor tissue to in vivo debrisoquine hydroxylase activity.
Correlation of PPM1A Downregulation with CYP3A4 Repression in the Tumor Liver Tissue of Hepatocellular Carcinoma Patients.
Correlation of xenobiotic-metabolizing enzymes, oxidative stress and NFkappaB signaling with histological grade and menopausal status in patients with adenocarcinoma of the breast.
Correspondence re: C. Chen et al., CYP2D6 genotype and the incidence of anal and vulvar cancer. Cancer Epidemiol. Biomark. Prev., 8: 317-321, 1999.
Correspondence re: letter to the editor by B. K. Tang and W. Kalow on CYP1A2 phenotyping using caffeine. Cancer Epidemiol. Biomarkers & Prev., 5: 231, 1996.
Coumarin metabolism by rat esophageal microsomes and cytochrome P450 2A3.
Critical appraisal of the expression of cytochrome P450 enzymes in human lung and evaluation of the possibility that such expression provides evidence of potential styrene tumorigenicity in humans.
Current evidence on the relationship between three polymorphisms in the CYP1A2 gene and the risk of cancer.
Current researches on breast cancer epidemiology in Korea.
CXCR4 promotes cisplatin-resistance of non-small cell lung cancer in a CYP1B1-dependent manner.
Cyclamen Trochopteranthum: Cytotoxic activity and possible adverse interactions including drugs and carcinogens.
Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis.
Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.
Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo.
Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells.
Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study.
CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer.
CYP genes in osteosarcoma: Their role in tumorigenesis, pulmonary metastatic microenvironment and treatment response.
CYP19 (aromatase cytochrome P450) gene expression in human malignant endometrial tumors.
CYP19 gene expression and aromatase activity in endometrial cancer tissue: importance of the type of the disease.
CYP19 genetic polymorphism haplotype AASA is associated with a poor prognosis in premenopausal women with lymph node-negative, hormone receptor-positive breast cancer.
CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies.
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms and bladder cancer risk in a Turkish population.
CYP1A1 activation of aminoflavone leads to DNA damage in human tumor cell lines.
CYP1A1 activity in renal cell carcinoma and in adjacent normal renal tissue.
CYP1A1 alleles in female genital cancers in the Polish population.
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
CYP1A1 and GSTM1 polymorphic genotypes in patients with prostate cancer in a Turkish population.
CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis.
CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses.
CYP1A1 and GSTP1 polymorphisms in an oral cancer case-control study.
CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx.
CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm.
CYP1A1 gene polymorphism as a risk factor for cervical intraepithelial neoplasia and invasive cervical cancer.
CYP1A1 gene polymorphisms: lack of association with breast cancer susceptibility in the southern region (Madurai) of India.
CYP1A1 I462V polymorphism is associated with reduced genotoxicity in yeast despite positive association with increased cancer risk.
CYP1A1 inducing potential of airborne particulate extracts collected during a 25-year period (1975-2000).
CYP1A1 Msp1 T/C polymorphism in esophageal cancer: no association and risk modulation.
CYP1A1 polymorphism and risk of gynecological malignancy in Japan.
CYP1A1 polymorphisms and the risk of upper aerodigestive tract cancers in an Indian population.
CYP1A1 protein activity is associated with allelic variation in pterygium tissues and cells.
CYP1A1 regulates breast cancer proliferation and survival.
CYP1A1 Relieves Lipopolysaccharide-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells.
CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people.
CYP1A1, CYP2E1, and GSTM1 Gene Polymorphisms and Susceptibility to Colorectal and Gastric Cancer Among Lebanese.
CYP1A1, GSTM1, GSTT1 and TP53 Polymorphisms and Risk of Gallbladder Cancer in Bolivians.
CYP1A1.
CYP1A1m2 polymorphisms regulate estrogen and interleukin-6 in lung cancer.
CYP1A2 F21L and F186L polymorphisms in an Italian population sample.
CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice.
CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies.
CYP1A2 suppresses hepatocellular carcinoma through antagonizing HGF/MET signaling.
CYP1B1 Activates Wnt/?-Catenin Signaling through Suppression of Herc5-Mediated ISGylation for Protein Degradation on ?-Catenin in HeLa Cells.
CYP1B1 and hormone-induced cancer.
CYP1B1 and predisposition to breast cancer in Poland.
CYP1B1 as a therapeutic target in cardio-oncology.
CYP1B1 C4326G polymorphism and susceptibility to cervical cancer in Chinese Han women.
CYP1B1 determines susceptibility to low doses of 7,12-dimethylbenz[a]anthracene-induced ovarian cancers in mice: correlation of CYP1B1-mediated DNA adducts with carcinogenicity.
CYP1B1 Enhances Cell Proliferation and Metastasis through Induction of EMT and Activation of Wnt/?-Catenin Signaling via Sp1 Upregulation.
CYP1B1 enhances the resistance of epithelial ovarian cancer cells to paclitaxel in vivo and in vitro.
Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates.
CYP1B1 expression in human lung.
CYP1B1 expression in ovarian cancer in the laying hen Gallusdomesticus.
CYP1B1 expression in prostate is higher in the peripheral than in the transition zone.
CYP1B1 expression is induced by docetaxel: effect on cell viability and drug resistance.
CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention.
CYP1B1 gene in endometrial cancer.
CYP1B1 gene polymorphisms correlate with an increased risk of urinary bladder cancer in India.
CYP1B1 gene: Implications in glaucoma and cancer.
CYP1B1 genotype and risk of cardiovascular disease, pulmonary disease, and cancer in 50,000 individuals.
CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma.
Cyp1B1 mRNA expression in correlation to cotinine levels with respect to the Cyp1B1 L432V gene polymorphism.
CYP1B1 Polymorphisms and K-ras Mutations in Patients with Pancreatic Ductal Adenocarcinoma.
CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKC? activation and phosphorylation of XIAP.
CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma.
CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers.
CYP1B1: A Unique Gene with Unique Characteristics.
CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence.
CYP24A1 as a Potential Target for Cancer Therapy.
Cyp24a1 attenuation limits progression of BrafV600E-induced papillary thyroid cancer cells and sensitizes them to BRAFV600E inhibitor PLX4720.
CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.
CYP24A1 is a potential biomarker for the progression and prognosis of human colorectal cancer.
CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma.
CYP24A1 rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System.
CYP24A1 splice variants-Implications for the antitumorigenic actions of 1,25-(OH)(2)D(3) in colorectal cancer.
CYP24A1-induced vitamin D insufficiency promotes breast cancer growth.
CYP27A1 and CYP24 expression as a function of malignant transformation in the colon.
CYP27A1 expression is associated with risk of late lethal estrogen receptor-positive breast cancer in postmenopausal patients.
CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer.
CYP2A5 Induction and Hepatocellular Stress: An Adaptive Response to Perturbations of Heme Homeostasis.
CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.
CYP2A6 and the plasma level of 5-chloro-2, 4-dihydroxypyridine are determinants of the pharmacokinetic variability of tegafur and 5-fluorouracil, respectively, in Japanese patients with cancer given S-1.
CYP2A6 genotyping methods and strategies using real-time and end point PCR platforms.
CYP2A6 overexpression in human lung cancers correlates with a high malignant status.
CYP2A6 polymorphisms and risk for tobacco-related cancers.
CYP2A6 polymorphisms in Malays, Chinese and Indians.
CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility.
Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer.
CYP2C8 and CYP2C9 polymorphisms in relation to tumour characteristics and early breast cancer related events among 652 breast cancer patients.
CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population.
CYP2C9 genotype does not affect risk of tobacco-related cancer in the general population.
CYP2C9 inhibits the invasion and migration of esophageal squamous cell carcinoma via downregulation of HDAC.
CYP2C9 polymorphisms in human tumors.
CYP2D6 and CYP1A1 mutations in the Turkish population.
CYP2D6 gene variants in urban/admixed and Amerindian populations of Venezuela: pharmacogenetics and anthropological implications.
CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen.
CYP2D6 genetic polymorphisms are associated with susceptibility to pituitary tumors.
CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women with Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial.
CYP2D6 genotype and the incidence of anal and vulvar cancer.
CYP2D6 genotype in relation to tamoxifen efficacy in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial.
CYP2D6 genotype predicts tamoxifen side effects but not cancer-free or survival benefits in postmenopausal ER+ and/or PgR+ breast cancers.
CYP2D6 variability in populations from Venezuela.
CYP2E1 and risk of chemically mediated cancers.
CYP2E1 genotyping in renal cell/urothelial cancer patients in comparison with control populations.
CYP2E1 polymorphism, cigarette smoking, p53 expression, and survival in non-small cell lung cancer: a long term follow-up study.
CYP2E1 polymorphisms and gene-environment interactions in the risk of upper aerodigestive tract cancers among Indians.
CYP2E1 PstI polymorphism increases cervical neoplasia risk: a meta-analysis.
CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.
CYP2E1 RsaI/PstI polymorphism and gastric cancer susceptibility: meta-analyses based on 24 case-control studies.
CYP2J2*7 single nucleotide polymorphism in a Chinese population.
CYP2W1 is highly expressed in adrenal glands and is positively associated with the response to mitotane in adrenocortical carcinoma.
CYP3A gene variability and cancer cells response to the treatment.
CYP3A genotypes and treatment response in paediatric acute lymphoblastic leukaemia.
CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.
CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation.
CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling.
CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer.
CYP3A5 genotype and midazolam clearance in Australian patients receiving chemotherapy.
CYP3A5 genotypes and risk of oesophageal cancer in two South African populations.
CYP3A5 is unlikely to mediate anticancer drug resistance in hepatocellular carcinoma.
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma.
CYP3A5*3 Affects Plasma Disposition of Noroxycodone and Dose Escalation in Cancer Patients Receiving Oxycodone.
CYP3A5*3 and bilirubin predict midazolam population pharmacokinetics in Asian cancer patients.
CYP450 pharmacogenetics for personalizing cancer therapy.
Cytochrome 450 metabolites of arachidonic acid (20-HETE, 11,12-EET and 14,15-EET) promote pheochromocytoma cell growth and tumor associated angiogenesis.
Cytochrome P-450 and acetyltransferase expression as biomarkers of carcinogen-DNA adduct levels and human cancer susceptibility.
Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats.
Cytochrome P1B1 (CYP1B1) polymorphisms and cancer risk: a meta-analysis of 52 studies.
Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer.
Cytochrome P450 1 family and cancers.
Cytochrome P450 1A1 and 1B1 promoter CpG island methylation regulates rat liver injury induced by isoniazid.
Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6.
Cytochrome P450 1A1 gene polymorphisms and digestive tract cancer susceptibility: a meta-analysis.
Cytochrome P450 1A1 genetic polymorphisms as cancer biomarkers.
Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls.
Cytochrome P450 1A1-mediated anticancer drug discovery: in silico findings.
Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins.
Cytochrome P450 1A2 Metabolizes 17?-Estradiol to Suppress Hepatocellular Carcinoma.
Cytochrome P450 1A2 overcomes nuclear factor kappa B-mediated sorafenib resistance in hepatocellular carcinoma.
Cytochrome P450 1B1 (CYP1B1) gene polymorphisms as predictors of anticancer drug activity: studies with in vitro models.
Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development.
Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease.
Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.
Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target.
Cytochrome P450 1B1 expression in human malignant tumours.
Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux.
Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation.
Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer.
Cytochrome P450 1B1 mRNA untranslated regions interact to inhibit protein translation.
Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma.
Cytochrome P450 1B1 promotes cancer cell survival via specificity protein 1 (Sp1)-mediated suppression of death receptor 4.
Cytochrome P450 1B1, a new keystone in gene-environment interactions related to human head and neck cancer?
Cytochrome P450 1B1: a major P450 isoenzyme in human blood monocytes and macrophage subsets.
Cytochrome P450 1B1: a novel anticancer therapeutic target.
Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies.
Cytochrome P450 2C9 mediated metabolism in people with and without cancer.
Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance.
Cytochrome P450 2E1 and its roles in disease.
Cytochrome P450 2E1 gene polymorphism and alcohol drinking on the risk of hepatocellular carcinoma: a meta-analysis.
Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects.
Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage.
Cytochrome P450 2E1 polymorphism in gastric cancer in Brazil: case-control studies of Japanese Brazilians and non-Japanese Brazilians.
Cytochrome p450 2E1 polymorphisms and the risk of gastric cardia cancer.
Cytochrome P450 2E1 variable number tandem repeat polymorphisms and health risks: a genotype-phenotype study in cancers associated with drinking and/or smoking.
Cytochrome P450 2W1 (CYP2W1) - ready for use as the biomarker and drug target for cancer?
Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers.
Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy.
Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes.
Cytochrome P450 4A11 expression in tumor cells: A favorable prognostic factor for hepatocellular carcinoma patients.
Cytochrome P450 4B1 (CYP4B1) as a target in cancer treatment.
Cytochrome P450 ?-Hydroxylases in Inflammation and Cancer.
Cytochrome P450 activation of arylamines and heterocyclic amines.
Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.
Cytochrome p450 and glutathione transferase expression in squamous cell cancer.
Cytochrome P450 aromatase expression in human seminoma.
Cytochrome P450 Bioconjugate as a Nanovehicle for Improved Chemotherapy Treatment.
Cytochrome P450 content in primary tumors and liver metastases of patients with metastatic colorectal cancer.
Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility.
Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention.
Cytochrome P450 CYP1B1 activity in renal cell carcinoma.
Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.
Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer.
Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance.
Cytochrome P450 CYP2D6 genotypes: association with hair colour, Breslow thickness and melanocyte stimulating hormone receptor alleles in patients with malignant melanoma.
Cytochrome P450 CYP2D6.
Cytochrome P450 CYP3A in human renal cell cancer.
Cytochrome P450 enzyme-mediated auto-enhanced photodynamic cancer therapy of co-nanoassembly between clopidogrel and photosensitizer.
Cytochrome P450 enzymes and tumor therapy.
Cytochrome P450 enzymes: novel options for cancer therapeutics.
Cytochrome p450 epoxygenase promotes human cancer metastasis.
Cytochrome P450 epoxygenases and cancer: A genetic and a molecular perspective.
Cytochrome P450 expression (CYP) in non-small cell lung cancer.
Cytochrome P450 expression in oesophageal cancer.
Cytochrome P450 expression in tumours.
Cytochrome P450 expression is a common molecular event in soft tissue sarcomas.
Cytochrome P450 for Cancer Prevention and Therapy.
Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer. Preface.
Cytochrome P450 gene polymorphism and cancer.
Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer.
Cytochrome P450 in Cancer Susceptibility and Treatment.
Cytochrome P450 interactions in human cancers: new aspects considering CYP1B1.
Cytochrome P450 isoenzyme mRNA expression pattern in human urinary bladder malignancies and normal urothelium.
Cytochrome P450 isoforms. Regulation during infection, inflammation and by cytokines.
Cytochrome P450 isozyme distribution in normal and tumor-bearing hepatic tissue from rainbow trout (Salmo gairdneri).
Cytochrome p450 metabolism of betel quid-derived compounds: implications for the development of prevention strategies for oral and pharyngeal cancers.
Cytochrome P450 pharmacogenetics and cancer.
Cytochrome P450 polymorphisms as risk factors for steroid hormone-related cancers.
Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Cytochrome P450 reductase dependent inhibition of cytochrome P450 2B1 activity: Implications for gene directed enzyme prodrug therapy.
Cytochrome p450 retinoic acid 4-hydroxylase inhibitors: potential agents for cancer therapy.
Cytochrome P450 Vitamin D Hydroxylases in Inflammation and Cancer.
Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency.
Cytochrome P450-activated prodrugs.
Cytochrome P450-based cancer gene therapy: recent advances and future prospects.
Cytochrome P450-based gene therapy for cancer treatment: from concept to the clinic.
Cytochrome P450-derived eicosanoids: the neglected pathway in cancer.
Cytochrome P450-isoenzyme 1A1 in susceptibility to tobacco-related lung cancer.
Cytochrome P4501A1 gene polymorphism and homozygous deletion of the glutathione S-transferase M1 gene in urothelial cancer patients.
Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene.
Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma.
Cytochrome P4502C9 genotype in Southeast Anatolia and possible relation with some serum tumour markers and cytokines.
Cytochrome P4502E1 (CYP2E1) Genetic Polymorphisms in a Lebanese Population: Frequency Distribution and Association with Morbid Diseases.
Cytochrome P4502E1 genetic polymorphisms and risk of nasopharyngeal carcinoma: results from a case-control study conducted in Taiwan.
Cytochrome P4502E1 inhibitor, chlormethiazole, decreases lipopolysaccharide-induced inflammation in rat Kupffer cells with ethanol treatment.
Cytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and Atherosclerosis
Cytochrome P450: what have we learned and what are the future issues?
Cytochromes P450 and cancer.
Cytochromes P450 in the bioactivation of chemicals.
Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aerodigestive tract cancer in alcoholic caucasians.
Cytokine-mediated down-regulation of CYP1A1 in Hepa1 cells.
Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.
Cytotoxic and potent CYP1 inhibitors from the marine algae Cymopolia barbata.
Cytotoxicity and cytochrome P450 inhibitory activities of Clinacanthus nutans.
Dafachronic acid inhibits C. elegans germ cell proliferation in a DAF-12-dependent manner.
DDE and PCB 153 independently induce aryl hydrocarbon receptor (AhR) expression in peripheral blood mononuclear cells.
Debrisoquine 4-hydroxylase (CYP2D6) genetic polymorphisms and susceptibility to schizophrenia in Chinese patients from Taiwan.
Debrisoquine hydroxylase gene polymorphism in neurofibromatosis type 1.
Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.
Decreased expression of cytochrome p450 1B1 in non-small cell lung cancer.
Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma.
Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma.
Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients.
Decreased hepatic drug metabolising enzyme activity in rats with nitrosamine-induced tumours.
Decreasing smoking behaviour and risk through CYP2A6 inhibition.
Deoxycorticosterone-secreting adrenocortical carcinoma.
Depression of constitutive murine cytochromes P450 by staphylococcal enterotoxin B.
Depression of hepatic drug metabolism in endotoxin-treated and sarcoma-bearing mice.
Deregulation of signaling pathways controlling cell survival and proliferation in cancer cells alters induction of cytochrome P450 family 1 enzymes.
Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial.
Design and synthesis of ?-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation.
Design and Synthesis of New ?-Naphthoflavones as Cytochrome P450 (CYP) 1B1 Inhibitors To Overcome Docetaxel-Resistance Associated with CYP1B1 Overexpression.
Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.
Design, Synthesis and Binding Affinity Evaluation of Cytochrome P450 1B1 Targeted Chelators.
Design, Synthesis, and Biological Evaluation of Cytochrome P450 1B1 Targeted Molecular Imaging Probes for Colorectal Tumor Detection.
Design, synthesis, and enzymatic characterization of quinazoline-based CYP1A2 inhibitors.
Desmethyl bosentan displays a similar in vitro interaction profile as bosentan.
Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor.
Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR.
Detection of Cytochrome P450 Polymorphisms in Breast Cancer Patients May Impact on Tamoxifen Therapy
Detection of three genetic polymorphisms in the 5'-flanking region and intron 1 of human CYP1A2 in the Japanese population.
Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts.
Determination of CYP2D6 *3, *4, and *10 frequency in women with breast cancer in São Luís, Brazil, and its association with prognostic factors and disease-free survival.
Developing a high-throughput system for the screening of cytochrome P450 1A1--inhibitory polyphenols.
Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles.
Development of an estrogen-dependent breast cancer co-culture model as a tool for studying endocrine disruptors.
Development of an In Vitro Model to Screen CYP1B1-Targeted Anticancer Prodrugs.
Development of benzochalcone derivatives as selective CYP1B1 inhibitors and anticancer agents.
Developmental regulation and induction of cytochrome P450 2W1, an enzyme expressed in colon tumors.
Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility--a review.
Dibenzo[A,L]pyrene-induced genotoxic and carcinogenic responses are dramatically suppressed in aryl hydrocarbon receptor-deficient mice.
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.
Dietary flavonoids in cancer therapy and prevention: substrates and inhibitors of cytochrome P450 CYP1 enzymes.
Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells.
Differences between Spaniards and Ecuadorians in CYP2A6 allele frequencies: comparison with other populations.
Differences in cytochrome P450 2C19 (CYP2C19) expression in adjacent normal and tumor tissues in Chinese cancer patients.
Different Dietary Proportions of Fish Oil Regulate Inflammatory Factors but Do Not Change Intestinal Tight Junction ZO-1 Expression in Ethanol-Fed Rats.
Different h2 receptor antihistamines dissimilarly retard the growth of xenografted human melanoma cells in immunodeficient mice.
Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs.
Different modes of Mhc evolution in primates.
Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.
Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450.
Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.
Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture.
Differential effects of flavonoid compounds on tumor promoter-induced activation of the human CYP1A2 enhancer.
Differential effects of omeprazole and lansoprazole enantiomers on aryl hydrocarbon receptor in human hepatocytes and cell lines.
Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells.
Differential expression of CYP1A1, CYP1A2, CYP1B1 in human kidney tumours.
Differential expression of cytochrome p450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma.
Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.
Differential induction of Cyp1a1, Cyp1b1, Ahd4, and Nmo1 in murine skin tumors and adjacent normal epidermis by ligands of the aryl hydrocarbon receptor.
Differential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants.
Differential oxidant potential of carcinogenic and weakly carcinogenic estrogens: Involvement of metabolic activation and cytochrome P450.
Differential regulation of CYP1A1 and CYP1B1 expression in resveratrol-treated human medulloblastoma cells.
Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats.
Differential regulation of multidrug resistance-associated protein 2 (MRP2) and cytochromes P450 2B1/2 and 3A1/2 in phenobarbital-treated hepatocytes.
Differential responses of sex steroid target tissues of rats treated with 4-hydroxyandrostenedione.
Differential sensitivity to lung tumorigenesis following transplacental exposure of mice to polycyclic hydrocarbons, heterocyclic amines, and lung tumor promoters.
Differential vitamin D 24-hydroxylase/CYP24A1 gene promoter methylation in endothelium from benign and malignant human prostate.
Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm.
Diminished CYP2E1 expression and formation of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene epoxide, in murine lung tumors.
Diminished expression of CYP1A1 in urethane-induced lung tumors in strain A/J mice: analysis by in situ hybridization and immunohistochemical methods.
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Diosmetin Induces Cell Apoptosis by Regulating CYP1A1/CYP1A2 Due to p53 Activation in HepG2 Cells.
Direct retroviral delivery of human cytochrome P450 2B6 for gene-directed enzyme prodrug therapy of cancer.
Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.
Discovery of a novel potent cytochrome P450 CYP4Z1 inhibitor.
Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).
Discovery of cytochrome P450 1B1 inhibitors as new promising anti-cancer agents.
Discovery of heterocycle-containing ?-naphthoflavone derivatives as water-soluble, highly potent and selective CYP1B1 inhibitors.
Discovery of inhibitors of MCF-7 tumor cell adhesion to endothelial cells and investigation on their mode of action.
Disparate distribution of 16 candidate single nucleotide polymorphisms among racial and ethnic groups of pediatric heart transplant patients.
Disposition of desipramine, a sensitive cytochrome P450 2D6 substrate, when coadministered with intravenous temsirolimus.
Disposition of imatinib and its metabolite CGP74588 in a patient with chronic myelogenous leukemia and short-bowel syndrome.
Distribution of soluble epoxide hydrolase, cytochrome P450 2C8, 2C9 and 2J2 in human malignant neoplasms.
Diversified expression of aryl hydrocarbon receptor dependent genes in human laryngeal squamous cell carcinoma cell lines treated with ?-naphthoflavone.
Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis.
DMAKO-20 as a new multi-target anticancer prodrug activated by the tumor specific CYP1B1 enzyme.
DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced p53-mediated apoptosis through activation of cytochrome P450/aryl hydrocarbon receptor.
DNA methylation and gene expression profiling of ewing sarcoma primary tumors reveal genes that are potential targets of epigenetic inactivation.
DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung.
DNA methylation-related vitamin D receptor insensitivity in breast cancer.
Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study.
Does cytochrome P450 1A1 MspI polymorphism increase acute lymphoblastic leukemia risk? Evidence from 2013 cases and 2903 controls.
Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver.
Down-regulation of aryl hydrocarbon receptor-regulated genes by tumor necrosis factor-alpha and lipopolysaccharide in murine hepatoma Hepa 1c1c7 cells.
Down-Regulation of CYP1A1 Expression in Breast Cancer.
Down-regulation of cytochrome P450 1A1 gene promoter by oxidative stress. Critical contribution of nuclear factor 1.
Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers.
Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma.
Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.
Drug interactions and pharmacogenetic factors contribute to variation in apixaban concentration in atrial fibrillation patients in routine care.
Drug interactions between antineoplastic and antiretroviral therapies: Implications and management for clinical practice.
Drug metabolic enzymes in developmental toxicology.
Drug metabolism and ageing.
Drug-metabolizing enzymes in pharyngeal mucosa and in oropharyngeal cancer tissue.
Drug-virus interaction: effect of administration of recombinant adenoviruses on the pharmacokinetics of docetaxel in a rat model.
Dual EGFR and ABL Tyrosine Kinase Inhibitor Treatment in a Patient with Concomitant EGFR-Mutated Lung Adenocarcinoma and BCR-ABL1-Positive CML.
Duodenal 7-ethoxycoumarin-o-deethylase activity in colon-cancer patients.
Dynamic Effects of CYP2D6 Genetic Variants in a Set of Poor Metaboliser Patients with Infiltrating Ductal Cancer Under Treatment with Tamoxifen.
Dysregulated estrogen receptor signaling in the hypothalamic-pituitary-ovarian axis leads to ovarian epithelial tumorigenesis in mice.
Dysregulation of Aromatase in Breast, Endometrial, and Ovarian Cancers: An Overview of Therapeutic Strategies.
Early life exposure to a rodent carcinogen propiconazole fungicide induces oxidative stress and hepatocarcinogenesis in medaka fish.
Effect of Chinese Herbal Monomer Hairy Calycosin on Nonalcoholic Fatty Liver Rats and its Mechanism.
Effect of Co-administration of Ketoconazole, a Strong CYP3A Inhibitor, on the Pharmacokinetics, Safety and Tolerability of Navitoclax, a First-in-class Oral Bcl-2 Family Inhibitor, in Cancer Patients.
Effect of common CYP3A4 and CYP3A5 variants on the pharmacokinetics of the cytochrome P450 3A phenotyping probe midazolam in cancer patients.
Effect of CYP19 rs6493497 and rs7176005 haplotype status on in vivo aromatase transcription, plasma and tissue estrogen levels in postmenopausal women.
Effect of CYP1A1 and GSTM1 genetic polymorphisms on bone tumor susceptibility.
Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density.
Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.
Effect of CYP2D6 polymorphisms on breast cancer recurrence.
Effect of CYP3A inhibitors on the pharmacokinetics of pevonedistat in patients with advanced solid tumours.
Effect of cytochrome P450 inducers on expression of oncogenes and a tumor suppressor gene in human colon cancer cells.
Effect of dioxin and 17?-estradiol on the expression of cytochrome P450 1A1 gene via an estrogen receptor dependent pathway in cellular and xenografted models.
Effect of genetic polymorphisms in CYP3A4, CYP3A5, and m-TOR on everolimus blood exposure and clinical outcomes in cancer patients.
Effect of germ-line genetic variation on breast cancer survival in a population-based study.
Effect of iron chelator, hydroxyl radical scavenger and cytochrome P450 inhibitors on the cytotoxicity of cisplatin to tumor cells.
Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Effect of polymorphic metabolizing genes on micronucleus frequencies among benzene-exposed shoe workers in China.
Effect of Pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes.
Effect of strain differences and tumor presence on microsomal drug metabolism in the guinea pig: brief communication.
Effect of thalidomide on endotoxin-induced decreases in activity and expression of hepatic cytochrome P450 3A2.
Effect of the allelic variants of ABCB1, CYP2D6 and HTR3B on response of ramosetron to prevent chemotherapy-induced nausea and vomiting in Korean cancer patients.
Effect of the Cytochrome P450 2C19 Inhibitor Omeprazole on the Pharmacokinetics and Safety Profile of Bortezomib in Patients with Advanced Solid Tumours, Non-Hodgkin's Lymphoma or Multiple Myeloma.
Effect of tumor promoters on induction of aryl hydrocarbon hydroxylase in human lymphocytes.
Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Tizanidine (a CYP1A2 Substrate) in Patients With BRAFV600 Mutation-Positive Malignancies.
Effects of 5-methoxypsoralen (5-MOP) on arylamine N-acetyltransferase activity in the stomach and colon of rats and human stomach and colon tumor cell lines.
Effects of adrenolytic mitotane on drug elimination pathways assessed in vitro.
Effects of Androgen Receptor Inhibition on Kanamycin-Induced Hearing Loss in Rats.
Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines.
Effects of arachidonic acid and indomethacin on sister-chromatid exchange induction by polycyclic aromatic hydrocarbons in mammalian cell lines.
Effects of artificial sweeteners on the AhR- and GR-dependent CYP1A1 expression in primary human hepatocytes and human cancer cells.
Effects of baicalein on the pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats: possible role of cytochrome p450 3A4 and P-glycoprotein inhibition by baicalein.
Effects of beta-carotene supplementation on molecular markers of lung carcinogenesis in male smokers.
Effects of carbon tetrachloride on oxidative stress, inflammatory response and hepatocyte apoptosis in common carp (Cyprinus carpio).
Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism.
Effects of curcumin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen, in rats: possible role of CYP3A4 and P-glycoprotein inhibition by curcumin.
Effects of CYP2D6 activity and tobacco on larynx cancer risk.
Effects of cytochrome P450 (CYP) 2A6 gene deletion and CYP2E1 genotypes on gastric adenocarcinoma.
Effects of cytochrome P450 arachidonic acid epoxygenases on the proliferation of tumor cells.
Effects of dietary and in vitro 2(3)-t-butyl-4-hydroxy-anisole and other phenols on hepatic enzyme activities in mice.
Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers.
Effects of Echinacea purpurea on Hepatic and Renal Toxicity Induced by Diethylnitrosamine in Rats.
Effects of ellagic Acid on angiogenic factors in prostate cancer cells.
Effects of genetically different strains of mice on the microsomal activation of 2-aminofluorene.
Effects of human blood levels of two PAH mixtures on the AHR signalling activation pathway and CYP1A1 and COMT target genes in granulosa non-tumor and granulosa tumor cell lines.
Effects of hypoxia and limited diffusion in tumor cell microenvironment on bystander effect of P450 prodrug therapy.
Effects of inflammatory cytokine gene polymorphisms on warfarin maintenance doses in Korean patients with mechanical cardiac valves.
Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats.
Effects of matrix components on aromatase activity in breast stromal cells in culture.
Effects of Neonicotinoid Pesticides on Promoter-Specific Aromatase (CYP19) Expression in Hs578t Breast Cancer Cells and the Role of the VEGF Pathway.
Effects of Oral Anorexiant Sibutramine on the Expression of Cytochromes P450s in Human Hepatocytes and Cancer Cell Lines.
Effects of polychlorinated dibenzofurans on compounds in hepatic DNA of female Sprague-Dawley rats: structure dependence and mechanistic considerations.
Effects of ready to drink teas on AhR- and PXR-mediated expression of cytochromes P450 CYP1A1 and CYP3A4 in human cancer cell lines and primary human hepatocytes
Effects of selenium on chemical carcinogenesis : Comparative effects of antioxidants.
Effects of the potential chemopreventive agent DMU-135 on adenoma development in the ApcMin+ mouse.
Effects of Vernonia cinerea Compounds on Drug-metabolizing Cytochrome P450s in Human Liver Microsomes.
Efficient hypoxic activation of the anticancer agent AQ4N by CYP2S1 and CYP2W1.
Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment.
Eldecalcitol (ED-71), an analog of 1?,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas.
Elevated levels of the Steroidogenic Factor-1 are associated with over-expression of CYP19 in an Estrogen producing testicular Leydig cell tumour.
Elimination of major side effects due to ROS of therapeuticals through biotransformation control of the 57 cytochromes P450 isoenzymes.
Elucidation of CYP2E1 5' regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer.
Elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cDNA microarray.
Emamectin benzoate induced enzymatic and transcriptional alternation in detoxification mechanism of predatory beetle Paederus fuscipes (Coleoptera: Staphylinidae) at the sublethal concentration.
Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures.
Enantioselective metabolism and cytotoxicity of R-Ifosfamide and S-Ifosfamide by tumor cell-expressed cytochromes P450.
Enantioselectivity in the cytochrome P450-dependent conversion of tegafur to 5-fluorouracil in human liver microsomes.
Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer.
Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond.
Engineered mesenchymal stem cells as vectors in a suicide gene therapy against preclinical murine models for solid tumors.
Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation.
Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11.
Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35.
Enhanced cancer growth in mice administered daily human-equivalent doses of some H1-antihistamines: predictive in vitro correlates.
Enhanced decomposition of oxyferrous cytochrome P450CIA1 (P450cam) by the chemopreventive agent 3-t-butyl-4-hydroxyanisole.
Enhanced expression of cytochrome P450 in stomach cancer.
Enhanced induction of cytochrome P450 enzymes and CAR binding in TNF (p55(-/-)/p75(-/-)) double receptor knockout mice following phenobarbital treatment.
Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and ?-naphthoflavone.
Enhancement of hepatocarcinogenesis and induction of specific cytochrome P450-dependent monooxygenase activities by the barbiturates allobarbital, aprobarbital, pentobarbital, secobarbital and 5-phenyl- and 5-ethylbarbituric acids.
Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model.
Enhancement of tumor growth by drugs with some common molecular actions.
Enhancer elements in the mouse CYP1A2 gene: a comparative sequencing among different inbred mouse strains.
Environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women.
Enzymatic activities of human lung tissue: relationship with smoking habits.
Enzymes Oxidizing the Azo Dye 1-Phenylazo-2-Naphthol (Sudan I) and their Contribution to its Genotoxicity and Carcinogenicity.
Enzymic and interindividual differences in the human metabolism of heterocyclic amines.
Epigenetic inactivation of the dioxin-responsive cytochrome P4501A1 gene in human prostate cancer.
Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity.
Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma.
Epigenetic silencing of novel tumor suppressors in malignant melanoma.
Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression.
Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species level, Mitochondrial Dysfunction, Caspase Activation and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide.
ER? phenotype, estrogen level, and benzo[a]pyrene exposure modulate tumor growth and metabolism of lung adenocarcinoma cells.
ERCC1 and CYP1B1 polymorphisms as predictors of response to neoadjuvant chemotherapy in estrogen positive breast tumors.
Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9).
Estradiol 17? and Its Metabolites Stimulate Cell Proliferation and Antagonize Ascorbic Acid-Suppressed Cell Proliferation in Human Ovarian Cancer Cells.
Estradiol-mediated suppression of CYP1B1 expression in mouse MA-10 Leydig cells is independent of protein kinase A and estrogen receptor.
Estrogen receptor alpha promotes smoking-carcinogen-induced lung carcinogenesis via cytochrome P450 1B1.
Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk.
Ethnic and genetic differences in metabolism genes and risk of toxicity and cancer.
Ethnic variation in the CYP2E1 gene: polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese.
Ethnic-related differences in the frequency distribution of genetic polymorphisms in the CYP1A1 and CYP1B1 genes in Japanese and Caucasian populations.
Evaluation of a real-time polymerase chain reaction method for the quantification of CYP1B1 gene expression in MCF-7 human breast carcinoma cells.
Evaluation of CYP1A1 and CYP2B1/2 m-RNA induction in rat liver slices using the NanoString technology: a novel tool for drug discovery lead optimization.
Evaluation of Drug-Drug Interactions of Rucaparib and CYP1A2, CYP2C9, CYP2C19, CYP3A, and P-gp Substrates in Patients With an Advanced Solid Tumor.
Evaluation of the Effects of Repeat-Dose Dabrafenib on the Single-Dose Pharmacokinetics of Rosuvastatin (OATP1B1/1B3 Substrate) and Midazolam (CYP3A4 Substrate).
Evaluation of the likelihood of a selective CHK1 inhibitor (LY2603618) to inhibit CYP2D6 with desipramine as a probe substrate in cancer patients.
Evaluation of the pharmacokinetic drug interaction potential of tivantinib (ARQ 197) using cocktail probes in patients with advanced solid tumours.
Everolimus-induced nephrotic syndrome precipitated by interaction with voriconazole in a patient with Hodgkin's lymphoma.
Evidence of a genetic relationship between susceptibility to 3-methyl-cholanthrene-induced subcutaneous tumors and inducibility of aryl hydrocarbon hydroxylase.
Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis.
Evidence that genetic variants of metabolic detoxication and cell cycle control are not related to gallbladder cancer risk in Chilean women.
Evolution of alachlor-induced nasal neoplasms in the Long-Evans rat.
Evolution of the cytochrome P450 genes.
Exhaled breath and oral cavity VOCs as potential biomarkers in oral cancer patients.
Expanding the view of breast cancer metabolism: Promising molecular targets and therapeutic opportunities.
Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene.
Exploring the relationship between lifestyles, diets and genetic adaptations in humans.
Exposure of human skin to benzo[a]pyrene: Role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation.
Expression and activity of taxane-metabolizing enzymes in ovarian tumors.
Expression and chromosomal localization of the cytochrome P1-450 gene in human mitogen-stimulated lymphocytes.
Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors.
Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines.
Expression of aromatase CYP19 and its relationship with parameters in NSCLC.
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis.
Expression of aromatase cytochrome P450 in rat H540 Leydig tumor cells.
Expression of CYP and GST in human normal and colon tumor tissues.
Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.
Expression of CYP1A1, CYP1B1 and MnSOD in a panel of human cancer cell lines.
Expression of CYP1C1 and CYP1A in Fundulus heteroclitus during PAH-induced carcinogenesis.
Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur.
Expression of cytochrome P 450 3A enzymes in human lung: a combined RT-PCR and immunohistochemical analysis of normal tissue and lung tumours.
Expression of cytochrome P450 1B1 and catechol-O-methyltransferase in breast tissue and their associations with breast cancer risk.
Expression of cytochrome P450 arachidonic acid epoxygenase 2J2 in human tumor tissues and cell lines.
Expression of cytochrome P450 CYP1B1 in breast cancer.
Expression of cytochrome P450 genes in CD34+ hematopoietic stem and progenitor cells.
Expression of cytochrome P450 in lung tumor.
Expression of cytochrome P450 in tumor tissues and its association with cancer development.
Expression of cytochrome P4502E1 in human liver: Relationship between genotype and phenotype in Chinese.
Expression of cytochromes P450 3A and P-glycoprotein in human large intestine in paired tumour and normal samples.
Expression of cytochromes P450 in human breast tissue and tumors.
Expression of Genes for Methylxanthine Pathway-Associated Enzymes Accompanied by Sex Steroid Receptor Status Impacts Breast Carcinoma Progression.
Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue.
Expression of glutathione S-transferases in fetal lung and liver tissue from parental strains and F1 crosses between C57BL/6 and BALB/c F1 mice following in utero exposure to 3-methylcholanthrene.
Expression of P450 Aromatase in Granulosa Cell Tumors and Sertoli-Stromal Cell Tumors of the Ovary: Which Cells Are Responsible for Estrogenesis?
Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy.
Expression of the aryl hydrocarbon receptor pathway and cyclooxygenase-2 in dog tumors.
Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis.
Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death.
Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer.
Expression of two cytochromes P450 involved in carcinogen activation in a human colon cell line.
Expression of VDR and CYP24A1 mRNA in human tumors.
Expression of xenobiotic and steroid hormone metabolizing enzymes in human breast carcinomas.
Expression of xenobiotic metabolizing enzymes in breast cancer.
Expression of xenobiotic metabolizing enzymes in tumours of the urinary bladder.
Expression of xenobiotic-metabolizing enzymes by primary and secondary hepatic tumors in man.
Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study.
Expression profile of CYP1A1 and CYP1B1 enzymes in colon and bladder tumors.
Expression profile of CYP1A1 and CYP1B1 enzymes in endometrial tumors.
Expression Profile of Genes Related to Drug Metabolism in Human Brain Tumors.
Expression profiling of CYP1B1 in oral squamous cell carcinoma: counterintuitive downregulation in tumors.
Expressions of cytochrome P450, UDP-glucuronosyltranferase, and transporter genes in monolayer carcinoma cells change in subcutaneous tumors grown as xenografts in immunodeficient nude mice.
Extra-hepatic isozymes from the CYP1 and CYP2 families as potential chemotherapeutic targets.
Familial and sporadic cases of nasopharyngeal carcinoma in Taiwan.
Features of the Copy Number Variation of Certain Genes in Tumor Cells in Patients with Serous Ovarian Adenocarcinoma.
Fetal mouse Cyp1b1 and transplacental carcinogenesis from maternal exposure to dibenzo(a,l)pyrene.
Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.
Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells.
Formation of a novel topotecan metabolite in the hormone-independent human prostate carcinoma cell lines DU-145 and PC-3.
Forskolin up-regulates aromatase (CYP19) activity and gene transcripts in the human adrenocortical carcinoma cell line H295R.
FOXO1 Negates the Cooperative Action of FOXL2C134W and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3.
Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population.
Frequency of common CYP1B1 polymorphic variations in Delhi population of Northern India.
Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population.
Frequency of the functionally relevant aryl hydrocarbon receptor repressor (AhRR) Pro185Ala SNP in Papua New Guinea.
Frequent CYP1A1 expression in gastric cancers and their related lesions.
Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy.
Function of the vitamin D endocrine system in mammary gland and breast cancer.
Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities.
Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity.
Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors.
Functional polymorphisms in the CYP2C19 gene contribute to digestive system cancer risk: evidence from 11,042 subjects.
Functional PstI/RsaI Polymorphism in CYP2E1 Is Associated with the Development, Progression and Poor Outcome of Gastric Cancer.
Functional PstI/RsaI Polymorphisms in the CYP2E1 Gene among South Indian Populations.
Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer.
Functional significance of cytochrome P450 1B1 in endometrial carcinogenesis.
Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients.
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling.
Future prospects of personalized chemotherapy in gastric cancer patients: results of a prospective randomized pilot study.
Gambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivo.
Gender differences in genetic susceptibility for lung cancer.
Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice.
Gene Expression of CYP1A1 and its Possible Clinical Application in Thyroid Cancer Cases.
Gene expression of vitamin D metabolic enzymes at baseline and in response to vitamin D treatment in thyroid cancer cell lines.
Gene expression profiles of CYP24A1 and CYP27B1 in malignant and normal breast tissues.
Gene therapy for malignant gliomas using replication incompetent retroviral and adenoviral vectors encoding the cytochrome P450 2B1 gene together with cyclophosphamide.
Gene therapy in pancreatic cancer.
Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis.
Gene-environment interactions associated with CYP1A1 MspI and GST polymorphisms and the risk of upper aerodigestive tract cancers in an Indian population.
Gene-environment interactions in determining differences in genetic susceptibility to cancer in subsites of the head and neck.
Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes.
Genetic analysis of colon tumors induced by a dietary carcinogen PhIP in CYP1A humanized mice: Identification of mutation of ?-catenin/Ctnnb1 as the driver gene for the carcinogenesis.
Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone.
Genetic Association of CYP1B1 4326 C>G Polymorphism with Disease-Free Survival in TNBC Patients Undergoing TAC Chemotherapy Regimen.
Genetic associations between CYP24A1 polymorphisms and predisposition of cancer: A meta-analysis.
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia.
Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle.
Genetic factors determining cutaneous basal cell carcinoma phenotype.
Genetic network and gene set enrichment analysis to identify biomarkers related to cigarette smoking and lung cancer.
Genetic polymorphism and cancer risk.
Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity.
Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity.
Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers.
Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.
Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers.
Genetic polymorphism of CYP2A6 in relation to cancer.
Genetic polymorphism of CYP2D6 influences susceptibility to papillary thyroid cancer.
Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematological neoplasias.
Genetic polymorphism of cytochrome P450 1A1 (Cyp1A1) and glutathione transferases (M1, T1 and P1) among Africans.
Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: regulation and toxicological significance.
Genetic polymorphism of cytochromes P450: interethnic differences and relationship to incidence of lung cancer.
Genetic polymorphism of drug metabolizing enzymes (CYP2E1, GSTP1) and susceptibility to bladder cancer in North India.
Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer.
Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer.
Genetic polymorphism of estrogen metabolizing enzymes in siberian women with breast cancer.
Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients.
Genetic polymorphism of metabolic enzymes P450 (CYP) as a susceptibility factor for drug response, toxicity, and cancer risk.
Genetic polymorphism of xenobiotic metabolising enzymes in Slovenian lung cancer patients.
Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population.
Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review).
Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer.
Genetic polymorphisms in ABCG2 and CYP1A2 are associated with imatinib dose reduction in patients treated for gastrointestinal stromal tumors.
Genetic polymorphisms in chronic obstructive pulmonary disease.
Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies.
Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response.
Genetic polymorphisms in promoter and intronic regions of CYP1A2 gene in Roma and Hungarian population samples.
Genetic polymorphisms in the cytochrome P450 1A1, glutathione S-transferase M1 and T1, and susceptibility to colon cancer.
Genetic polymorphisms in the vitamin D pathway in relation to lung cancer risk and survival.
Genetic polymorphisms of CYP1A1, GSTM1 and P53 genes in a unique Siberian population of Tundra Nentsi and its pharmacogenetic importance.
Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients.
Genetic Polymorphisms of CYP2D6 Oxidation in Patients with Inflammatory Bowel Disease.
Genetic polymorphisms of CYP2D6, GSTM1, and GSTT1 genes and bladder cancer risk in North India.
Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: Association with hepatitis B related advanced liver disease and cancer.
Genetic polymorphisms of CYP2E1 and GSTM1 in a Thai population.
Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India.
Genetic polymorphisms of cytochrome P450 in patients with hepatitis C virus-associated hepatocellular carcinoma.
Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan.
Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer.
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer.
Genetic sequence variants in vitamin D metabolism pathway genes, serum vitamin D level and outcome in head and neck cancer patients.
Genetic susceptibility to iatrogenic malignancy.
Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types.
Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients.
Genetic variants of CYP19 (aromatase) and breast cancer risk.
Genetic variants of CYP2D6 gene and cancer risk: a HuGE systematic review and meta-analysis.
Genetic variants of UGT1A6 influence risk of colorectal adenoma recurrence.
Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.
Genetic variation of CYP2A6, smoking, and risk of cancer.
Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women.
Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer.
Genetics of CYP1A1: coamplification of specific alleles by polymerase chain reaction and association with breast cancer.
Genetics of susceptibility of mice to inhibition of interferon induction by benzo-(a)-pyrene.
Genistein affects expression of cytochrome P450 (CYP450) genes in hepatocellular carcinoma (HEPG2/C3A) cell line.
Genistein decreases basal hepatic cytochrome P450 1A1 protein expression and activity in Swiss Webster mice.
Genistein-induced changes in gene expression in Panc 1 cells at physiological concentrations of genistein.
Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.
Genomic Sequencing of Cancer-related Genes in Sinonasal Squamous Cell Carcinoma and Coexisting Inverted Papilloma.
Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: The role of quinones.
Genotype of Null Polymorphisms in Genes GSTM1, GSTT1, CYP1A1, and CYP1A1*2A (rs4646903 T>C)/CYP1A1*2C (rs1048943 A>G) in Patients with Larynx Cancer in Southeast Spain.
Genotype/phenotype comparisons: a probe for the effect of disease progression on drug metabolism.
Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevitY. Role of CYP2D6 and CYP2C19 in longevity.
Genotyping and phenotyping cytochrome P450: perspectives for cancer treatment.
Genotyping of the CYP1A1 and GSTM1 genes in esophageal carcinoma patients with special reference to smoking.
Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection.
Ginkgo biloba extract EGb 761-mediated inhibition of aromatase for the treatment of hormone-dependent breast cancer.
Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis.
Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis.
Glutathione S-Transferases and Cytochrome P450 Enzyme Expression in Patients with Intracranial Tumors: Preliminary Report of 55 Patients.
Glutathione-S-transferase M1 and T1 and cytochrome P1A1 genetic polymorphisms and susceptibility to cervical intraepithelial neoplasia in Greek women.
GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.
Growth and characterization of N-methyl-N-nitrosourea-induced mammary tumors in intact and ovariectomized rats.
GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp.
GSTM1 enzyme concentration and enzyme activity in correlation to the genotype of detoxification enzymes in squamous cell carcinoma of the oral cavity.
GSTT1, GSTM1, and CYP1B1 gene polymorphisms and susceptibility to sporadic renal cell cancer.
Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.
Has the era of individualised medicine arrived for antifungals? A review of antifungal pharmacogenomics.
Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.
Helicobacter hepaticus-Induced Liver Tumor Promotion Is Associated with Increased Serum Bile Acid and a Persistent Microbial-Induced Immune Response.
Helicobacter pylori infection, but not genetic polymorphism of CYP2E1, is highly prevalent in gastric cancer patients younger than 40 years.
Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis.
Hepatic cytochrome P450 3A drug metabolism is reduced in cancer patients who have an acute-phase response.
Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.
Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice.
Hepatic metabolism and carcinogenesis. Its role in hepatoma and adenocarcinoma.
Hepatitis B virus downregulates vitamin D receptor levels in hepatoma cell lines, thereby preventing vitamin D-dependent inhibition of viral transcription and production.
Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.
Hepatocellular carcinoma: gene expression profiling and regulation of xenobiotic-metabolizing cytochromes P450.
Hepatoprotective effect of gastrodin against alcohol-induced liver injury in mice.
Hepatoprotective effect of methylsulfonylmethane against carbon tetrachloride-induced acute liver injury in rats.
Hepatoprotective effects of hoveniae semen cum fructus extracts in ethanol intoxicated mice.
Hepatoprotective Effects of Steamed and Freeze-Dried Mature Silkworm Larval Powder against Ethanol-Induced Fatty Liver Disease in Rats.
Hepatotoxicity prevention in Acetaminophen-induced HepG2 cells by red betel (Piper crocatum Ruiz and Pav) extract from Indonesia via antioxidant, anti-inflammatory, and anti-necrotic.
Hereditary Hypercalcemia Caused by a Homozygous Pathogenic Variant in the CYP24A1 Gene: A Case Report and Review of the Literature.
Heteroactivation of cytochrome P450 1A1 by teas and tea polyphenols.
Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine.
High Coffee Intake, but Not Caffeine, is Associated with Reduced Estrogen Receptor Negative and Postmenopausal Breast Cancer Risk with No Effect Modification by CYP1A2 Genotype.
High dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats.
High TGFbeta1, estrogen receptor, and aromatase gene expression in a large cell calcifying sertoli cell tumor (LCCSCT): implications for the mechanism of oncogenesis.
High-meat diets and cancer risk.
High-throughput evaluation of CYP1A1 and 2B1 induction in rat liver slices using a semi-automated system.
Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine.
Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells.
Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene.
Host CYP27A1 expression is essential for ovarian cancer progression.
Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O(6)-methylguanine levels are associated with GSTT1 genotype and O(6)-alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype.
How autophagy controls the intestinal epithelial barrier.
Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin.
Human CYP1A1 inhibition by flavonoids.
Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.
Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation?
Human CYP2D6 gene polymorphism in Slovene cancer patients and healthy controls.
Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid.
Human Cytochrome P450 2E1 Mutations that Alter Mitochondrial Targeting Efficiency and Susceptibility to Ethanol-induced Toxicity in Cellular Models.
Human Cytochrome P450 2W1 Is Not Expressed in Adrenal Cortex and Is Only Rarely Expressed in Adrenocortical Carcinomas.
Human cytochrome P450 liability studies of trans-dihydronarciclasine: a readily available, potent, and selective cancer cell growth inhibitor.
Human cytochrome P4501A2.
Human cytochromes P450: evolution and cDNA-directed expression.
Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.
Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription.
Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.
Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo.
Human relevance framework for rodent liver tumors induced by the insecticide sulfoxaflor.
Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators.
Hyperglycemic Ins2AkitaLdlr-/- mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease.
Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation.
Hyperlipidemia exacerbates cerebral injury through oxidative stress, inflammation and neuronal apoptosis in MCAO/reperfusion rats.
Hypermethylation of carcinogen metabolism genes, CYP1A1, CYP2A13 and GSTM1 genes in head and neck cancer.
Hypomethylation and hypoexpression of human CYP2E1 gene in lung tumors.
Hypopharyngeal cancer risk in Japanese: Genetic polymorphisms related to the metabolism of alcohol- and tobacco-associated carcinogens.
Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia.
Hypoxia-mediated tumour targeting.
Iatrogenic vitamin D toxicity in an infant - a case report and review of literature.
Identification of 19-(S/R)Hydroxyeicosatetraenoic Acid as the First Endogenous Noncompetitive Inhibitor of Cytochrome P450 1B1 with Enantioselective Activity.
Identification of a less toxic vinca alkaloid derivative for use as a chemotherapeutic agent, based on in silico structural insights and metabolic interactions with CYP3A4 and CYP3A5.
Identification of a new HLA-A*0201-restricted cryptic epitope from CYP1B1.
Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors.
Identification of a novel co-transcription of P450/1A1 with telomerase in A549.
Identification of biomarkers predicting the chemotherapeutic outcomes of capecitabine and oxaliplatin in patients with gastric cancer.
Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families.
Identification of CYP1B1-specific candidate inhibitors using combination of in silico screening, integrated knowledge-based filtering, and molecular dynamics simulations.
Identification of CYP2C9*2 Allele in HepG2 Cell Line.
Identification of genetic variations associated with drug resistance in non-small cell lung cancer patients undergoing systemic treatment.
Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository.
Identification of key genes in endometrioid endometrial adenocarcinoma via TCGA database.
Identification of leads for antiproliferative activity on MDA-MB-435 human breast cancer cells through pharmacophore and CYP1A1-mediated metabolism.
Identification of PGRMC1 as a Candidate Oncogene for Head and Neck Cancers and Its Involvement in Metabolic Activities.
Identification of Potent and Selective CYP1A1 Inhibitors via Combined Ligand and Structure-Based Virtual Screening and Their in Vitro Validation in Sacchrosomes and Live Human Cells.
Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.
Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.
Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies.
Immunoglobulin light chain, Blimp-1 and cytochrome P4501B1 peptides as potential vaccines for AL amyloidosis.
Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues.
Immunohistochemical detection of CYP2E1 and 2-S-glutathionyl acetate in murine lung tumors: diminished formation of reactive intermediates of 1,1-dichloroethylene.
Immunohistochemical evaluation of cytochrome P450 (CYP) and p53 in breast cancer.
Immunohistochemical localization of cytochrome P450 2E1 in human pulmonary carcinoma and normal bronchial tissue.
Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1.
Immunohistochemical studies of steroidogenic enzymes (aromatase, 17 alpha-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary.
Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody.
Immunolocalization of aromatase P-450 in ovarian tissue from pregnant and nonpregnant mares and in ovarian tumours.
Immunopharmacology 2011: an updated report of clinical achievements and perspectives.
Immunopropylactic approaches against chemical carcinogenesis.
Immunosuppressive effects of 3-methylcholanthrene given intratracheally in various inbred strains of mice.
Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer.
Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons.
Impact of Alternaria toxins on CYP1A1 expression in different human tumor cells and relevance for genotoxicity.
Impact of CYP genotype and inflammatory markers on the plasma concentrations of tramadol and its demethylated metabolites and drug tolerability in cancer patients.
Impact of CYP1A1, GSTM1, and GSTT1 polymorphisms in overall and specific prostate cancer survival.
Impact of CYP24A1 overexpression on growth of colorectal tumour xenografts in mice fed with vitamin D and soy.
Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among Opioid-Treated Oncology Patients.
Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy.
Impact of CYP2E1 genotype in renal cell and urothelial cancer patients.
Impact of CYP3A5 and ABCB1 Gene Polymorphisms on Fentanyl Pharmacokinetics and Clinical Responses in Cancer Patients Undergoing Conversion to a Transdermal System.
Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies.
Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China.
Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model.
Impact of vitamin D metabolism on clinical epigenetics.
Impacts of Cytochrome P450 2D6 (CYP2D6) Genetic Polymorphism in Tamoxifen Therapy for Breast Cancer.
Impaired cholesterol metabolism in the mouse model of cystic fibrosis. A preliminary study.
Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy.
Impaired tamoxifen metabolism reduces survival in familial breast cancer patients.
Impaired Vitamin D Signaling Is Associated With Frequent Development of Renal Cell Tumor in End-stage Kidney Disease.
Implications of cytochrome P450 genetic polymorphisms on the toxicity of antitumor agents.
Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer.
Important role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistance.
Improvement of cyclophosphamide activation by CYP2B6 mutants: from in silico to ex vivo.
In silico and biochemical analyses identify quinone reductase 2 as a target of piceatannol.
In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.
In silico identification and screening of CYP24A1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis.
In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.
In silico screening and analysis of nonsynonymous SNPs in human CYP1A2 to assess possible associations with pathogenicity and cancer susceptibility.
In vitro and in vivo primate evaluation of carbon-11-etomidate and carbon-11-metomidate as potential tracers for PET imaging of the adrenal cortex and its tumors.
In Vitro and In Vivo Study on the Toxic Effects of Propiconazole Fungicide in the Pathogenesis of Liver Fibrosis.
In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin.
In vitro assessment of inhibition by natural polyphenols of metabolic activation of procarcinogens by human CYP1A1.
In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1.
In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1.
In vitro cancer chemopreventive properties of polysaccharide extract from the brown alga, Sargassum latifolium.
In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by alpha-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct.
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus.
In vitro inhibitory effects of ganoderic acid A on human liver cytochrome P450 enzymes.
In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility.
In vitro metabolism of aflatoxin B1 by normal and tumorous liver tissue from Thailand.
In vitro prostaglandin H synthase- and monooxygenase-mediated binding of aflatoxin B1 to DNA in guinea-pig tissue microsomes.
In vivo effect of molybdenum on benzo(a)pyrene metabolism in liver and lung rat microsomes.
In vivo effects of interleukin-10 on human cytochrome P450 activity.
In-depth proteome analysis of the rubber particle of Hevea brasiliensis (para rubber tree).
Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer.
Increased CYP24A1 expression is associated with BRAF(V600E) mutation and advanced stages in papillary thyroid carcinoma.
Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D3-based therapies.
Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.
Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats.
Individualization of cancer therapy based on cytochrome P450 polymorphism: a pharmacogenetic approach.
Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).
Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction.
Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol.
Induction of apoptosis by a stilbene analog involves Bax translocation regulated by p38 MAPK and Akt.
Induction of aryl hydrocarbon hydroxylase activity and pulmonary carcinoma.
Induction of aryl hydrocarbon hydroxylase and forestomach tumors ben benzo(a)pyrene.
Induction of aryl hydrocarbon hydroxylase in mouse tissues from a high and low cancer strain and their F 1 hybrids.
Induction of cyclooxygenase-2 by tumor promoters in transformed and cytochrome P450 2E1-expressing hepatocytes.
Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity.
Induction of cytochrome P-450 1A1 by omeprazole in human HepG2 cells is protein tyrosine kinase-dependent and is not inhibited by alpha-naphthoflavone.
Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage.
Induction of estradiol metabolism by dietary indole-3-carbinol in humans.
Induction of fibroblast growth factor-9 and interleukin-1alpha gene expression by motorcycle exhaust particulate extracts and benzo(a)pyrene in human lung adenocarcinoma cells.
Induction of mono-oxygenase activity in prostaglandin H synthase-competent ovine seminal vesicle cell cultures by 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene.
Induction of the human CYP1A2 enhancer by phorbol ester.
Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance.
Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts.
Inflammation-induced phenoconversion of polymorphic drug metabolizing enzymes: hypothesis with implications for personalized medicine.
Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-?-catenin signalling, the stem cell phenotype and disease progression.
Inflammatory conditions induce IRES-dependent translation of cyp24a1.
Influence of antioxidants and the CYP1A1 isoleucine to valine polymorphism on the smoking--lung cancer association.
Influence of arylamine N-acetyltransferase, sex, and age on 4-aminobiphenyl-induced in vivo mutant frequencies and spectra in mouse liver.
Influence of beta-naphthoflavone on 7,12-dimethylbenz(a)anthracene metabolism, DNA adduction, and tumorigenicity in rainbow trout.
Influence of cAMP on reporter bioassays for dioxin and dioxin-like compounds.
Influence of CYP2C8 polymorphisms on imatinib steady-state trough level in chronic myeloid leukemia and gastrointestinal stromal tumor patients.
Influence of Cytochrome P450, ABC and SLC Gene Polymorphisms on Imatinib Therapy Outcome of Patients with Gastrointestinal Stromal Tumours (GIST).
Influence of heredity on human sensitivity to environmental chemicals.
Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease.
Influence of solute carriers on the pharmacokinetics of CYP3A4 probes.
Influence of the Cyp1B1 L432V gene polymorphism and exposure to tobacco smoke on Cyp1B1 mRNA expression in human leucocytes.
Inhibin and activin differentially regulate androgen production and 17 alpha-hydroxylase expression in human ovarian thecal-like tumor cells.
Inhibition of 17?-estradiol activation by CYP1A1: Genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols.
Inhibition of 3-methylcholanthrene-induced skin tumorigenicity in BALB/c mice by chronic oral feeding of trace amounts of ellagic acid in drinking water.
Inhibition of aldose reductase ameliorates alcoholic liver disease by activating AMPK and modulating oxidative stress and inflammatory cytokines.
Inhibition of apoptosis in rat hepatocytes treated with 'non-dioxin-like' polychlorinated biphenyls.
Inhibition of aromatase activity and of endocrine-responsive tumor growth by 10-propargylestr-4-ene-3, 17-dione and its 17-propionate derivative.
Inhibition of calcitriol inactivating enzyme CYP24A1 gene expression by flavonoids in hepatocellular carcinoma cells under normoxia and hypoxia.
Inhibition of Carcinogen-Activating Cytochrome P450 Enzymes by Xenobiotic Chemicals in Relation to Antimutagenicity and Anticarcinogenicity.
Inhibition of estrogen-induced kidney carcinogenesis in Syrian hamsters by modulators of estrogen metabolism.
Inhibition of glutathione S-transferase P1-1 in mouse lung epithelial cells by the tumor promoter 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone (BHT-quinone methide): protein adducts investigated by electrospray mass spectrometry.
Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS/MS method for the analysis of estradiol product formation.
Inhibition of rat hepatic CYP2E1 by quinacrine: molecular modeling investigation and effects on 4-(methyl nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mutagenicity.
Inhibition of rat liver cytochrome P450 isozymes by isothiocyanates and their conjugates: a structure-activity relationship study.
Inhibitors and Prodrugs Targeting CYP1: a Novel Approach in Cancer Prevention and Therapy.
Inhibitors of cytochrome P450 (CYP) 1B1.
Inhibitors of cytochrome P450 suppress tumor necrosis factor production.
Inhibitory Effect of 5-Fluorouracil on Cytochrome P450 2C9 Activity in Cancer Patients.
Inhibitory effect of soluble EP2 receptor on ovarian tumor growth in nude mice and utility of TMPRSS4 as a combinatorial molecular target.
Inhibitory effect of TMK688 on skin tumor initiation caused by 7,12-dimethylbenz[a]anthracene in relation to inhibition of aryl hydrocarbon hydroxylase activity and Cyp1a1 mRNA induction.
Inhibitory effects of chrysoeriol on DNA adduct formation with benzo[a]pyrene in MCF-7 breast cancer cells.
Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075).
Injection of encapsulated cells producing an ifosfamide-activating cytochrome P450 for targeted chemotherapy to pancreatic tumors.
Inoculation of human tumor cells alters the basal expression but not the inducibility of Cyp enzymes in tumor-bearing mouse liver.
Integrated Proteomics and Bioinformatics to Identify Potential Prognostic Biomarkers in Hepatocellular Carcinoma.
Inter-ethnic differences in genetic polymorphisms of xenobiotic-metabolizing enzymes (CYP1A1, CYP2D6, NAT1 and NAT2) in healthy populations: correlation with the functional in silico prediction.
Interaction between CYP 2C19*3 polymorphism and smoking in relation to laryngeal carcinoma in the Chinese Han population.
Interaction between cytochrome P-450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese.
Interaction between dietary acrylamide intake and genetic variants for estrogen receptor-positive breast cancer risk.
Interaction between smoking history and gene expression levels impacts survival of breast cancer patients.
Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer.
Interaction of heterogeneous nuclear ribonucleoprotein A1 with cytochrome P450 2A6 mRNA: implications for post-transcriptional regulation of the CYP2A6 gene.
Interaction of N-(2-Hydroxypropyl)methacrylamide Copolymer-Doxorubicin Conjugates with Human Liver Microsomal Cytochromes P450: Comparison with Free Doxorubicin.
Interactions between prostaglandin E(2), liver receptor homologue-1, and aromatase in breast cancer.
Interactions of Alectinib with Human ATP-Binding Cassette Drug Efflux Transporters and Cytochrome P450 Biotransformation Enzymes: Effect on Pharmacokinetic Multidrug Resistance.
Interactions of renal cytochrome P450 (CYP), angiotensin (AII) and tumor necrosis factor-alpha (TNF): implications for ion transport.
Interest and attitudes of patients, cancer physicians, medical students and cancer researchers towards a spectrum of genetic tests relevant to breast cancer patients.
Interindividual differences in nicotine metabolism and genetic polymorphisms of human CYP2A6.
Interindividual variations in aprepitant plasma pharmacokinetics in cancer patients receiving cisplatin-based chemotherapy for the first time.
Interleukin-1? and tumor necrosis factor-? affect cytochrome P450 expression in cynomolgus macaque hepatocytes.
Interleukin-1alpha and tumor necrosis factor alpha modulate cytochrome P450 activities in carp (Cyprinus carpio).
Interleukin-1beta, interleukin-6, tumour necrosis factor-alpha and interferon-gamma released by a viral infection and an aseptic inflammation reduce CYP1A1, 1A2 and 3A6 expression in rabbit hepatocytes.
Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3.
Interleukins-12 and -23 do not alter expression or activity of multiple cytochrome p450 enzymes in cryopreserved human hepatocytes.
Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice.
Intratumoral activation of cyclophosphamide by retroviral transfer of the cytochrome P450 2B1 in a pancreatic tumor model. Combination with the HSVtk/GCV system.
Intratumoral Sterol-27-Hydroxylase (CYP27A1) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer.
Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies.
Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse.
Investigation into the antioxidant role of arginine in the treatment and the protection for intralipid-induced non-alcoholic steatohepatitis.
Involvement of cytochrome P450 enzymes in inflammation and cancer: a review.
Involvement of Cytochrome P450 in Reactive Oxygen Species Formation and Cancer.
Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver.
Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.
Involvement of the arachidonic acid cytochrome P450 epoxygenase pathway in the proliferation and invasion of human multiple myeloma cells.
Irbesartan mitigates acute liver injury, oxidative stress, and apoptosis induced by acetaminophen in mice.
Irinotecan pharmacokinetic and pharmacogenomic alterations induced by methylselenocysteine in human head and neck xenograft tumors.
Is an alternative drug delivery system needed for docetaxel? The role of controlling epimerization in formulations and beyond.
Is aryl hydrocarbon hydroxylase activity a new prognostic indicator for breast cancer?
Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes.
Itraconazole-enhanced chemotherapy toxicity in a patient with Hodgkin lymphoma.
Joint effects of inflammation and androgen metabolism on prostate cancer severity.
Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1.
Ki-ras mutations are an early event and correlate with tumor stage in transplacentally-induced murine lung tumors.
Kidney injury and alterations of inflammatory cytokine expressions in mice following long-term exposure to cerium chloride.
Labeled 3-aryl-4-indolylmaleimide derivatives and their potential as angiogenic PET biomarkers.
Lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment.
Lack of association among polymorphic xenobiotic-metabolizing enzyme genotypes and the occurrence and progression of oral carcinoma in a Brazilian population.
Lack of association between CYP2A5 induction and apoptosis in mouse primary hepatocytes.
Lack of association between polymorphisms in the CYP1A2 gene and risk of cancer: evidence from meta-analyses.
Lack of Association of CYP1A1 Polymorphism with Prostate Cancer Susceptibility of Tunisian Men.
Lack of association of CYP1A1-MspI SNP and GSTM1 null genotypes with cancer in a Brazilian family with unusually high cancer incidence.
Lack of associations among cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the physicians' health study.
Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver.
Lessons for pharmacogenomics studies: association study between CYP2D6 genotype and tamoxifen response.
Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2.
Liposome mediated-CYP1A1 gene silencing nanomedicine prepared using lipid film-coated proliposomes as a potential treatment strategy of lung cancer.
Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action.
Lobatin B inhibits NPM/ALK and NF-?B attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation.
Localization and expression of adrenocorticotropic hormone receptor mRNA in normal and neoplastic human adrenal cortex.
Localization of Cytochrome P4502E1 Enzyme in Normal and Cancerous Gastric Mucosa and Association with Its Genetic Polymorphism in Unoperated and Remnant Stomach.
Localized aberrant expression of cytochrome P450 aromatase in primary and metastatic malignant tumors of human liver.
Long-chain carboxychromanols are the major metabolites of tocopherols and tocotrienols in A549 lung epithelial cells but not HepG2 cells.
Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells.
Long-term exposure of 4-hydroxyestradiol induces the cancer cell characteristics via upregulating CYP1B1 in MCF-10A cells.
Loss of alanine-glyoxylate and serine-pyruvate aminotransferase expression accelerated the progression of hepatocellular carcinoma and predicted poor prognosis.
Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma.
Loss of tumor-promoting activity of unleaded gasoline in N-nitrosodiethylamine-initiated ovariectomized B6C3F1 mouse liver.
Low CYP1A2 activity in rural Shona children of Zimbabwe.
Low CYP24A1 mRNA expression and its role in prognosis of breast cancer.
Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: possible mechanisms.
Low hepatic glutathione S-transferase and increased hepatic DNA adduction contribute to increased tumorigenicity of aflatoxin B1 in newborn and partially hepatectomized mice.
Low synthesis of retinoic acid due to impaired cytochrome P450 1a1 expression in mouse xeroderma pigmentosum fibroblasts.
Lower levels of urinary 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) in humans with higher CYP1A2 activity.
Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway.
Lymphocyte aromatic hydrocarbon responsiveness in acute leukemia of childhood.
Lymphocyte cytochrome P450 expression: inducibility studies in male Wistar rats.
Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation.
Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.
Mallory body formation by ethanol feeding in drug-primed mice.
Maltol Improves APAP-Induced Hepatotoxicity by Inhibiting Oxidative Stress and Inflammation Response via NF-?B and PI3K/Akt Signal Pathways.
Mapping in pig of genes involved in sexual differentiation: AMH, WT1, FTZF1, SOX2, SOX9, AHC, and placental and embryonic CYP19.
Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes.
Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy.
Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice.
Meat, metabolic genotypes and risk for colorectal cancer.
Mechanism Comparison of Gemcitabine and Dasatinib-Resistant Pancreatic Cancer by Integrating mRNA and miRNA Expression Profiles.
Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin.
Mechanisms of alcohol-associated cancers: introduction and summary of the symposium.
Mechanisms of chemical cooperative carcinogenesis by epidermal Langerhans cells.
Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells.
Mechanistic study on liver tumor promoting effects of flutamide in rats.
Membrane topology and search for potential redox partners of colon cancer-specific cytochrome P450 2W1.
Meta-analyses of the effect of cytochrome P450 2E1 gene polymorphism on the risk of head and neck cancer.
Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review.
Meta-analysis of association studies of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese.
Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) mice.
Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1.
Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1.
Metabolic behavior prediction of pazopanib by cytochrome P450 (CYP) 3A4 by molecular docking.
Metabolic characteristics and enflurane defluorination of cytochrome P450-dependent monooxygenases in human hepatocellular carcinoma.
Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans.
Metabolic polymorphisms and carcinogen-DNA adduct formation in human populations.
Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells.
Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human CYP1B1 genetic variants.
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human placental microsomes.
Metabolism of benzo(a)pyrene in animals with high aryl hydrocarbon hydroxylase levels and high rates of spontaneous cancer.
Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1.
Metabolism of the soyabean isoflavone daidzein by CYP1A2 and the extra-hepatic CYPs 1A1 and 1B1 affects biological activity.
Metabolomics reveals that tumor xenografts induce liver dysfunction.
Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes.
Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.
Methylation patterns of genes coding for drug-metabolizing enzymes in tamoxifen-resistant breast cancer tissues.
MGMT- and P450 3A-inhibitors do not sensitize glioblastoma cell cultures against nitrosoureas.
Micro1278 Leads to Tumor Growth Arrest, Enhanced Sensitivity to Oxaliplatin and Vitamin D and Inhibits Metastasis via KIF5B, CYP24A1, and BTG2, Respectively.
Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma.
Microencapsulated, CYP2B1-transfected cells activating ifosfamide at the site of the tumor: the magic bullets of the 21st century.
MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1.
Microsomal metabolites of the aryl hydrocarbon hydroxylase and tumour inhibitor 7,8-benzoflavone.
Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.
Mining the NCI screening database: explorations of agents involved in cell cycle regulation.
Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients.
miR-204 functions as a tumor suppressor gene, at least partly by suppressing CYP27A1 in glioblastoma.
miR-30a promoter variation contributes to the increased risk of colorectal cancer in an Iranian population.
Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells.
Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk.
Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation.
Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment.
Modification of DENA-induced hepatocarcinogenesis by CCl4 cirrhosis. Comparison of the marker enzyme patterns.
Modification of paclitaxel metabolism in a cancer patient by induction of cytochrome P450 3A4.
Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release.
Modulation of Aromatase by Phytoestrogens.
Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors.
Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options.
Modulation of cytochrome P450 activity: implications for cancer therapy.
Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic.
Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line.
Modulation of hepatic cytochrome P450s by citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice.
Modulation of human cytochrome P450 1B1 expression by 2,4,3',5'-tetramethoxystilbene.
Modulation of xenobiotic-metabolizing enzymes by ethanolic neem leaf extract during hamster buccal pouch carcinogenesis.
Molecular aspects and chemoprevention of dimethylaminoazobenzene-induced hepatocarcinogenesis: A review.
Molecular aspects of brain aromatase cytochrome P450.
Molecular Basis of Cancer Pain Management: An Updated Review.
Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma.
Molecular cloning and expression of novel alternatively spliced cytochrome P450 2E1 mRNAs in humans.
Molecular dynamics simulation studies for DNA sequence recognition by reactive metabolites of anticancer compounds.
Molecular epidemiology and urothelial cancer.
Molecular epidemiology of breast cancer: a review.
Molecular epidemiology of preterm delivery: methodology and challenges.
Molecular genetic analysis of the cytochrome P450-debrisoquine hydroxylase locus and association with cancer susceptibility.
Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment.
Molecular genetics of cancer susceptibility.
Molecular genetics of the human cytochrome P450-dependent monooxygenases.
Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine.
Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles.
Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer.
Molecular pathogenesis of transplacentally induced mouse lung tumors.
Molecular pathways involved in the improvement of non-alcoholic fatty liver disease.
Monitoring Cyp2b10 mRNA expression at cessation of 2-year carcinogenesis bioassay in mouse liver provides evidence for a carcinogenic mechanism devoid of human relevance: The dalcetrapib experience.
Mono-(2-ethylhexyl) phthalate induces NR4A subfamily and GIOT-1 gene expression, and suppresses CYP19 expression in human granulosa-like tumor cell line KGN.
Monodictyochromes A and B, Dimeric Xanthone Derivatives from the Marine Algicolous Fungus Monodictys putredinis.
Mouse lung tumors exhibit specific Ki-ras mutations following transplacental exposure to 3-methylcholanthrene.
MspI and Ile462Val polymorphisms in CYP1A1 and overall cancer risk: a meta-analysis.
Multi-omics characterization and validation of MSI-related molecular features across multiple malignancies.
Multifunctionalized biocatalytic P22 nanoreactor for combinatory treatment of ER+ breast cancer.
Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies.
Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual.
Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: main effect of indole-3-carbinol.
Multiplex PCR with confronting two-pair primers for CYP1A1 Ile462Val, GSTM1, GSTT1, and NQO1 C609T.
Mutagenicity of cytochrome P450 2E1 substrates in the Ames test with the metabolic competent S. typhimurium strain YG7108pin3ERb5.
Mutation and protein expression analysis of CYP1A1 gene-a study on female breast cancer cases from India.
N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents.
N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine (DPPE; tesmilifene), a chemopotentiating agent with hormetic effects on DNA synthesis in vitro, may improve survival in patients with metastatic breast cancer.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis.
N-Hydroxylation of 4-Aminobiphenyl by CYP2E1 Produces Oxidative Stress in a Mouse Model of Chemically Induced Liver Cancer.
Naphthalene DNA Adduct Formation and Tolerance in the Lung.
Natural anticarcinogens, carcinogens, and changing patterns in cancer: some speculation.
Natural Cancer Therapy and Prevention Targeted on Cancer Cells and Cancer Stem Cells Based on the Cytochrome P45O Enzyme CYP1B1: A Commentary.
Naturally occurring coumarins inhibit human cytochromes P450 and block benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene DNA adduct formation in MCF-7 cells.
Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism.
Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase.
New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments.
New CYP2A6 gene deletion and conversion variants in a population of Black African descent.
New cytochrome P450 isoforms as cancer biomarkers and targets for chemopreventive and chemotherapeutic agents.
New developments in hormone receptor-positive disease.
New ifosfamide analogs designed for lower associated neurotoxicity and nephrotoxicity with modified alkylating kinetics leading to enhanced in vitro anticancer activity.
New opportunities in cancer risk evaluation using PCR-based DNA analysis for CYP2D6.
New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol.
NF-?B and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice.
Nitric oxide-independent suppression of P450 2C11 expression by interleukin-1beta and endotoxin in primary rat hepatocytes.
No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.
No effect of thromboxane A2 on the attachment of tumor cell lines MDA MB 231, DU145, and U937 to the basement membrane in an in-vitro model.
Nonparametric expectation maximisation (NPEM) population pharmacokinetic analysis of caffeine disposition from sparse data in adult caucasians: systemic caffeine clearance as a biomarker for cytochrome P450 1A2 activity.
Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.
Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells.
Novel single nucleotide polymorphisms (SNPs) of CYP2W1 gene in Chinese Uygur and Han populations.
Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1.
Nutrition and enzyme inducers in liver tumor promotion in human and rat.
Nutrition and the prevention and treatment of cancer: association of cytochrome P450 CYP1B1 with the role of fruit and fruit extracts.
Oestrogen-receptors (ER) are likely to be promiscuous: wider role for oestrogens and mimics.
Of humans and hamsters: A comparative evaluation of carcinogen activation, DNA damage, cell proliferation, apoptosis, invasion, and angiogenesis in oral cancer patients and hamster buccal pouch carcinomas.
Oleanolic Acid Protects the Skin from Particulate Matter-Induced Aging.
Oltipraz inhibits 3-methylcholanthrene induction of CYP1A1 by CCAAT/enhancer-binding protein activation.
Omega-6-derived oxylipin changes in serum of patients with hepatitis B virus-related liver diseases.
On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice.
On the relationship between VDR, ROR? and ROR? receptors expression and HIF1-? levels in human melanomas.
Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1.
Oncogenic Potential of CYP24A1 in Lung Adenocarcinoma.
Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
Oral and oropharyngeal cancer, aryl hydrocarbon hydroxylase inducibility and smoking. A follow-up study.
Oral anticoagulation with warfarin is significantly influenced by steroids and CYP2C9 polymorphisms in children with cancer.
Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct.
Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm.
Oral paclitaxel and concurrent cyclosporin A: targeting clinically relevant systemic exposure to paclitaxel.
Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: a dose escalation and pharmacologic study.
Origin of an ovarian steroid cell tumor causing isosexual pseudoprecocious puberty demonstrated by the expression of adrenal steroidogenic enzymes and adrenocorticotropin receptor.
Otoprotective Effects of Zingerone on Cisplatin-Induced Ototoxicity.
Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions.
Ovarian Tumors With Functioning Stroma: A Clinicopathologic Study With Special Reference to Serum Estrogen Level, Stromal Morphology, and Aromatase Expression.
Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin.
Overexpression of CYP2A6 in human colorectal tumors.
Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis.
Overexpression of cytochrome P450 1B1 in advanced non-small cell lung cancer: a potential therapeutic target.
Overexpression of cytochrome P450 2A6 in adrenocortical carcinoma.
Overexpression of the cytochrome p450 activator hpr6 (heme-1 domain protein/human progesterone receptor) in tumors.
Overexpression of the heme oxygenase gene in renal cell carcinoma.
Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.
Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor.
Oxidations of 17beta-estradiol and estrone and their interconversions catalyzed by liver, mammary gland and mammary tumor after acute and chronic treatment of rats with indole-3-carbinol or beta-naphthoflavone.
P-glycoprotein associated with diabetes mellitus and survival of patients with pancreatic cancer: 8-year follow-up.
P450 and human cancer.
P450 CYP1B1 mediated fluorescent tumor markers: a potentially useful approach for photodynamic therapy, diagnosis and establishing surgical margins.
P450 enzyme expression patterns in the NCI human tumor cell line panel.
P450 genes: evolution, regulation, and relationship to human cancer and pharmacogenetics.
P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer.
P450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing.
P450-expression in brain tumors.
p53 gene mutations, and CYP1A1 and GSTM1 genotypes in pulmonary squamous cell carcinomas.
p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer.
p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use.
Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans.
Paradoxic effects of metformin on endothelial cells and angiogenesis.
Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes.
Pathway Crosstalk Analysis of Microarray Gene Expression Profile in Human Hepatocellular Carcinoma.
Pathway-dependent inhibition of paclitaxel hydroxylation by kinase inhibitors and assessment of drug-drug interaction potentials.
Patterns of cancer genetic testing: a randomized survey of Oregon clinicians.
Patterns of expression of cytochrome P450 genes in progression of hepatitis C virus-associated hepatocellular carcinoma.
Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T.
Peroxidase-dependent bioactivation and oxidation of DNA and protein in benzo[a]pyrene-initiated micronucleus formation.
Peroxisome proliferator-induced hepatocarcinogenesis: levels of activating and detoxifying enzymes in hepatocellular carcinomas induced by ciprofibrate.
Personalized Cancer Therapy Considering Cytochrome P450 Variability.
Perspective of structural flexibility on selective inhibition towards CYP1B1 over CYP1A1 by ?-naphthoflavone analogs.
PGRMC1: a new biomarker for the estrogen receptor in breast cancer.
PGRMC2, a yet uncharacterized protein with potential as tumor suppressor, migration inhibitor, and regulator of cytochrome P450 enzyme activity.
Pharmacogenetic phenotyping and genotyping. Present status and future potential.
Pharmacogenetic variants and response to neoadjuvant single-agent doxorubicin or docetaxel: a study in locally advanced breast cancer patients participating in the NCT00123929 phase 2 randomized trial.
Pharmacogenetics and cancer chemotherapy.
Pharmacogenetics and regulation of human cytochrome P450 1B1: implications in hormone-mediated tumor metabolism and a novel target for therapeutic intervention.
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes.
Pharmacogenetics: detecting sensitive populations.
Pharmacogenomics of tamoxifen and irinotecan therapies.
Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450.
Pharmacokinetic (PK) drug interaction studies of cabozantinib: Effect of CYP3A inducer rifampin and inhibitor ketoconazole on cabozantinib plasma PK and effect of cabozantinib on CYP2C8 probe substrate rosiglitazone plasma PK.
Pharmacokinetic drug interactions of gefitinib with rifampicin, itraconazole and metoprolol.
Pharmacokinetic studies with recombinant cytokines. Scientific issues and practical considerations.
Pharmacokinetics of 5-fluorouracil in mutant Nagase analbuminemic rats: faster metabolism of 5-fluorouracil via CYP1A.
Pharmacokinetics of S-1 and CYP2A6 genotype in Japanese patients with advanced cancer.
Pharmacologic and phenotypic study of docetaxel in patients with ovarian or primary peritoneal cancer.
Pharmacological Targets and the Biological Mechanisms of Formononetin for Alzheimer's Disease: A Network Analysis.
Phase I and pharmacological study of the pulmonary cytotoxin 4-ipomeanol on a single dose schedule in lung cancer patients: hepatotoxicity is dose limiting in humans.
Phase I study of cabazitaxel plus cisplatin in patients with advanced solid tumors: study to evaluate the impact of cytochrome P450 3A inhibitors (aprepitant, ketoconazole) or inducers (rifampin) on the pharmacokinetics of cabazitaxel.
Phase I study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma.
Phase I/II clinical trial of encapsulated, cytochrome P450 expressing cells as local activators of cyclophosphamide to treat spontaneous canine tumours.
Phase II study of 4-ipomeanol, a naturally occurring alkylating furan, in patients with advanced hepatocellular carcinoma.
Phase II study of S-1 combined with oxaliplatin as therapy for patients with metastatic biliary tract cancer: influence of the CYP2A6 polymorphism on pharmacokinetics and clinical activity.
Phenobarbital increases DNA adduct and metabolites formed by ochratoxin A: role of CYP 2C9 and microsomal glutathione-S-transferase.
Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion.
Phenotypic CYP2A6 variation and the risk of pancreatic cancer.
Pheochromocytoma and sub-clinical Cushing's syndrome during pregnancy: diagnosis, medical pre-treatment and cure by laparoscopic unilateral adrenalectomy.
Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo.
Physical activity and cancer prevention : pathways and targets for intervention.
Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions.
Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1.
Phytotherapeutic approach: a new hope for polycyclic aromatic hydrocarbons induced cellular disorders, autophagic and apoptotic cell death.
Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer.
Pleomorphic (giant and/or spindle cell) carcinoma of lung shows a high percentage of variant CYP1A12.
Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population.
Polymorphic cytochromes P450 and drugs used in psychiatry.
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes.
Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma.
Polymorphism in CYP1A1 and CYP2D6 genes: possible association with susceptibility to lung cancer.
Polymorphism in CYP24A1 Is Associated with Lung Cancer Risk: A Case-Control Study in Chinese Female Nonsmokers.
Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers.
Polymorphism of CYP450 and cancer susceptibility.
Polymorphism of cytochrome P450 and xenobiotic toxicity.
Polymorphism of metabolizing genes and lung cancer histology: prevalence of CYP2E1 in adenocarcinoma.
Polymorphisms and endometriosis: a systematic review and meta-analyses.
Polymorphisms for chemical metabolizing genes and risk for cervical neoplasia.
Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients.
Polymorphisms in drug-metabolizing enzymes and risk to head and neck cancer: evidence for gene-gene and gene-environment interaction.
Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol.
Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men.
Polymorphisms in the CYP1B1 gene are associated with increased risk of prostate cancer.
Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk.
Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses.
Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese.
Polymorphisms of cytochrome P450 1A1, glutathione S-transferases M1 and T1 in a Turkish population.
Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.
Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study.
Polymorphisms of genes encoding drug transporters or cytochrome P450 enzymes and association with clinical response in cancer patients: a systematic review.
Polymorphisms of human N-acetyltransferases and cancer risk.
Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk.
Polymorphisms of the CYP1A1 and GSTM1 genes in relation to individual susceptibility to lung carcinoma in Chinese population.
Polymorphisms of the CYP1A1, CYP2E1 and XRCC1 genes and cancer risk in a Southern Italian population: a case-control study.
Polymorphisms of the CYP1B1 gene as risk factors for human renal cell cancer.
Polymorphisms of tumor necrosis factor-alpha, interleukin-10, cytochrome P450 3A5 and ABCB1 in Chinese liver transplant patients treated with immunosuppressant tacrolimus.
Polymorphisms related to estrogen and xenobiotic metabolism in healthy Turkish women.
Poor metabolizer genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with Helicobacter pylori infection.
Poor Metabolizers at the Cytochrome P450 2C19 Loci Is at Increased Risk of Developing Cancer in Asian Populations.
Population pharmacokinetics and pharmacogenetics of vincristine in paediatric patients treated for solid tumour diseases.
Population pharmacokinetics and pharmacokinetics/pharmacodynamics of bendamustine in pediatric patients with relapsed/refractory acute leukemia.
Population Pharmacokinetics of Phenytoin Based on NONMEN in Patients with Intracranial Tumor during the First Week of Post-craniotomy.
Possible role of riboflavin deficiency in epithelial neoplasia. 3. Induction of microsomal aryl hydrocarbon hydroxylase.
Post-initiation treatment of rats with indole-3-carbinol or beta-naphthoflavone does not suppress 7, 12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis.
Potent antitumor and antineoplastic efficacy of baicalein on benzo(a)pyrene-induced experimental pulmonary tumorigenesis.
Potent inhibition of human cytochrome P450 1 enzymes by dimethoxyphenylvinyl thiophene.
Potent inhibition of human cytochrome P450 1B1 by tetramethoxystilbene.
Potent inhibitory effects of suicide inhibitors of P450 isozymes on 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene initiated skin tumors.
Potential contribution of cytochrome P450 2B6 to hepatic 4-hydroxycyclophosphamide formation in vitro and in vivo.
Potential differences in breast cancer risk factors based on CYP1A1 MspI and African-American-specific genotypes.
Potential for estrogen synthesis and action in human normal and neoplastic thyroid tissues.
Potential pathogenetic link between angiomyofibroblastoma and superficial myofibroblastoma in the female lower genital tract based on a novel MTG1-CYP2E1 fusion.
Potential role of CYP1B1 in the development and treatment of metabolic diseases.
Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein.
Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene.
Preclinical studies of amixicile, a systemic therapeutic developed for treatment of Clostridium difficile infections that also shows efficacy against Helicobacter pylori.
Prediction of paclitaxel resistance in breast cancer: is CYP1B1*3 a new factor of influence?
Prediction of the drug-drug interaction potential of the ?1-acid glycoprotein bound, CYP3A4/CYP2C9 metabolized oncology drug, erdafitinib.
Predominance of a cell population less sensitive to carcinogenesis in neoplastic cells of 3-methylcholanthrene-induced tumors in mouse aggregation chimeras.
Preferential inducibility of CYP1A1 and CYP1A2 by TCDD: differential regulation in primary human hepatocytes versus transformed human cells.
Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia.
Prenylflavonoids from hops inhibit the metabolic activation of the carcinogenic heterocyclic amine 2-amino-3-methylimidazo[4, 5-f]quinoline, mediated by cDNA-expressed human CYP1A2.
Pretranslational down-regulation of cytochromes P450 2C11 and 3A2 in male rat liver by tumor necrosis factor alpha.
Pretreatment with black tea polyphenols modulates xenobiotic-metabolizing enzymes in an experimental oral carcinogenesis model.
Prevalence of five pharmacologically most important CYP2C9 and CYP2C19 allelic variants in the population from the Republic of Srpska in Bosnia and Herzegovina.
Preventive medical services not covered by public health insurance at Daiko Medical Center in Japan, 2004-2011.
Primary amenorrhea revealing an occult progesterone-secreting ovarian tumor.
Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells.
Primary gene-engineered neural stem/progenitor cells demonstrate tumor-selective migration and antitumor effects in glioma.
Principal xenobiotic-metabolizing enzyme systems in human head and neck squamous cell carcinoma.
Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds.
Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking.
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
Prodrugs: effective solutions for solubility, permeability and targeting challenges.
Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
Profiling Deleterious Non-synonymous SNPs of Smoker's Gene CYP1A1.
Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers.
Profiling the expression of cytochrome P450 in breast cancer.
Progesterone potentiates the growth inhibitory effects of calcitriol in endometrial cancer via suppression of CYP24A1.
Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms.
Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes.
Progestins inhibit calcitriol-induced CYP24A1 and synergistically inhibit ovarian cancer cell viability: An opportunity for chemoprevention.
Prognostic significance of germ line polymorphisms of the CYP1A1 and glutathione S-transferase genes in patients with non-small cell lung cancer.
Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.
Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking.
Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice.
Promoter Hypermethylation Profiling Identifies Subtypes of Head and Neck Cancer with Distinct Viral, Environmental, Genetic and Survival Characteristics.
Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons.
Promotion of preneoplastic lesions and induction of CYP2B by unleaded gasoline vapor in female B6C3F1 mouse liver.
Properties of aryl hydrocarbon hydroxylase in microsomes of Morris hepatoma 5123D and the host liver.
Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways.
Proteasomal degradation of human CYP1B1: effect of the Asn453Ser polymorphism on the post-translational regulation of CYP1B1 expression.
Protective effect of a polysaccharide from Anoectochilus roxburghii against carbon tetrachloride-induced acute liver injury in mice.
Protective effects of combined Losartan and Nilotinib on carbon tetrachloride (CCl4)-induced liver fibrosis in rats.
Protective effects of dioscin against alcohol-induced liver injury.
Protective Effects of Silymarin, Alone or in Combination with Chlorogenic Acid and/or Melatonin, Against Carbon Tetrachloride-induced Hepatotoxicity.
Protein kinase A-dependent synergism between GATA factors and the nuclear receptor, liver receptor homolog-1, regulates human aromatase (CYP19) PII promoter activity in breast cancer cells.
Pulmonary toxicity in mice following exposure to cerium chloride.
Pulmotoxicological effects caused by long-term titanium dioxide nanoparticles exposure in mice.
Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors.
Quantitation of P450 aromatase immunoreactivity in human ovary during the menstrual cycle: relationship between the enzyme activity and immunointensity.
Quantitative assessment of the influence of cytochrome P450 2C19 gene polymorphisms and digestive tract cancer risk.
Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: correlation study with induction in vivo.
Quinazoline derivatives as selective CYP1B1 inhibitors.
Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway.
Rabbit cytochrome P450 4B1: A novel prodrug activating gene for pharmacogene therapy of hepatocellular carcinoma.
Radical differences in CYP1A1 genotype and function.
Radiosynthesis of [(124)I]Iodometomidate and Biological Evaluation Using Small-Animal PET.
Rare naturally occurring immune responses to three epitopes from the widely expressed tumour antigens hTERT and CYP1B1 in multiple myeloma patients.
Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism.
Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.
Re: London,S.J. et al. (1997) Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County. Carcinogenesis, 18, 1203-1214.
Re: S. J. London et al., Lung cancer risk in African-Americans in relation to a race-specific CYP1A1 polymorphism. Cancer Res., 55: 6035-6037, 1995.
Real-time genotyping of cytochrome P4501A1 A4889G and T6235C polymorphisms.
Real-time reverse transcription PCR assay of CYP19 expression: application to a well-defined series of post-menopausal breast carcinomas.
Recalling P446. P4501A1 (CYP1A1) opting for clinical application.
Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen.
Recombinant antibody piezoimmunosensors for the detection of cytochrome P450 1B1.
Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1.
Recombinant tumor necrosis factor depresses cytochrome P450-dependent microsomal drug metabolism in mice.
Recurrent gene amplifications in human type I endometrial adenocarcinoma detected by fluorescence in situ hybridization.
Red meat intake, CYP2E1 genetic polymorphisms, and colorectal cancer risk.
Reduction in 7,12-dimethylbenz[a]anthracene-induced hepatic cytochrome-P450 1A1 expression following soy consumption in female rats is mediated by degradation of the aryl hydrocarbon receptor.
Refinement of an ovarian cancer tumour suppressor gene locus on chromosome arm 22q and mutation analysis of CYP2D6, SREBP2 and NAGA.
Regional and cellular distribution of CYP2D subfamily members in rat brain.
Regional mapping of short tandem repeats on human chromosome 10: cytochrome P450 gene CYP2E, D10S196, D10S220, and D10S225.
Regulated CYP19 aromatase transcription in breast stromal fibroblasts.
Regulation of aromatase gene expression in purified germ cells of adult male rats: effects of transforming growth factor beta, tumor necrosis factor alpha, and cyclic adenosine 3',5'-monosphosphate.
Regulation of CYP19 gene expression in primary human osteoblasts: effects of vitamin D and other treatments.
Regulation of Cytochrome P450 1B1 Expression by Luteinizing Hormone in Mouse MA-10 and Rat R2C Leydig Cells: Role of Protein Kinase A.
Regulation of cytochrome P450 gene expression in human colon and breast tumour xenografts.
Regulation of cytochrome P450 IID by acute phase mediators in C3H/HeJ mice.
Regulation of drug resistance by human pregnane X receptor in breast cancer.
Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1.
Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.
Relationship between aromatase activity and steroid receptor levels in ovarian tumors from postmenopausal women.
Relationship Between CYP1A1 Genetic Polymorphisms and Renal Cancer in China.
Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in colorectal cancer.
Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China.
Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility.
Relationship between the plasma fentanyl and serum 4?-hydroxycholesterol based on CYP3A5 genotype and gender in patients with cancer pain.
Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice.
Relative Expression of Vitamin D Hydroxylases, CYP27B1 and CYP24A1, and of Cyclooxygenase-2 and Heterogeneity of Human Colorectal Cancer in Relation to Age, Gender, Tumor Location, and Malignancy: Results from Factor and Cluster Analysis.
Relevance of glutathione S-transferase M1 and cytochrome P450 1A1 genetic polymorphisms to the development of head and neck cancers.
Renal Transcriptomics Reveals the Carcinogenic Mechanism of Ethyl Carbamate in Musalais.
Repeated immunization with plasmid DNA formulated in poly(lactide-co-glycolide) microparticles is well tolerated and stimulates durable T cell responses to the tumor-associated antigen cytochrome P450 1B1.
Resveratrol enhances the sensitivity of cholangiocarcinoma to chemotherapeutic agents.
Resveratrol is a selective human cytochrome P450 1A1 inhibitor.
Rethinking tamoxifen in the management of melanoma: New answers for an old question.
Retinoic acid antagonizes basal as well as coal tar and glucocorticoid-induced cytochrome P4501A1 expression in human skin.
Retraction: Polymorphisms of the CYP1B1 Gene as Risk Factors for Human Renal Cell Cancer.
Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy.
Reversal of tumor-associated hyperglucagonemia as treatment for cancer cachexia.
Review article: the potential mechanisms of action of rifaximin in the management of inflammatory bowel diseases.
Review of studies on metabolic genes and cancer in populations of African descent.
Right and left-sided colon cancers - specificity of molecular mechanisms in tumorigenesis and progression.
Risk genes in head and neck cancer: a systematic review and meta-analysis of last 5 years.
Risk of testicular germ cell cancer in relation to variation in maternal and offspring cytochrome p450 genes involved in catechol estrogen metabolism.
RNA expression of cytochrome P450 in breast cancer patients.
RNA-sequencing studies identify genes differentially regulated during inflammation-driven lung tumorigenesis and targeted by chemopreventive agents.
Role and importance of polymorphisms with respect to DNA methylation for the expression of CYP2E1 enzyme.
Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract.
Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness.
Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells.
Role of CYP1A2 1F polymorphism in cancer risk: evidence from a meta-analysis of 46 case-control studies.
Role of CYP1A2 polymorphisms on lung cancer risk in a prospective study.
Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo.
Role of CYP4F2 as a novel biomarker regulating malignant phenotypes of liver cancer cells via the Nrf2 signaling axis.
Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation.
Role of cytochrome P450 activity in the fate of anticancer agents and in drug resistance: focus on tamoxifen, paclitaxel and imatinib metabolism.
Role of cytochrome P450 phenotyping in cancer treatment.
Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity.
Role of cytokines in the lipopolysaccharide-evoked depression of cytochrome P450 in the brain and liver.
Role of DNA adducts in hormonal carcinogenesis.
Role of endoplasmic reticulum stress in lipopolysaccharide-inhibited mouse granulosa cell estradiol production.
Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium.
Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation.
Role of host susceptibility to toxicity and cancer caused by pesticides: cytochromes P450.
Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP.
Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma.
Role of melatonin in the epigenetic regulation of breast cancer.
Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers.
Role of nitric oxide and nuclear factor-kappaB in the CYP2E1 potentiation of tumor necrosis factor alpha hepatotoxicity in mice.
Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide.
Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation.
Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes.
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction.
Role of the maternal environment in determining susceptibility to transplacentally induced chemical carcinogenesis in mouse fetuses.
Role of the progesterone receptor (PR) in the regulation of inflammatory response pathways and aromatase in the breast.
Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin.
Role of xenobiotic metabolism in cancer: involvement of transcriptional and miRNA regulation of P450s.
Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens.
Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms.
Roles of nitric oxide in inflammatory downregulation of human cytochromes P450.
RRM1, TUBB3, TOP2A, CYP19A1, CYP2D6: Difference between mRNA and protein expression in predicting prognosis of breast cancer patients.
RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma.
RT-PCR-based cytochrome P450 expression profile of oral tissue samples.
S-1 plus irinotecan and oxaliplatin for the first-line treatment of patients with metastatic colorectal cancer: a prospective phase II study and pharmacogenetic analysis.
S-Warfarin Limited Sampling Models to Estimate Area Under the Concentration Versus Time Curve for Cytochrome P450 2C9 Baseline Activity and Following Induction.
S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling.
Safety of triazole antifungal drugs in patients with cancer.
Salutary clinical response of prostate cancer to antiandrogen withdrawal: assessment of flutamide in an in vitro paradigm predictive of tumor growth enhancement.
Samarium enriches antitumor activity of ZnO nanoparticles via downregulation of CXCR4 receptor and cytochrome P450.
Selection of cytochrome p450 genes for use in prodrug activation-based cancer gene therapy.
Selective Antitumor Effect of Shikonin Derived DMAKO-20 on Melanoma through CYP1B1.
Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions.
Selective inhibitors of vitamin D metabolism--new concepts and perspectives.
Selective inhibitory effects of HYIpro-3-1 on CYP1A2 in human liver microsomes.
Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen.
Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Self-packed core shell nano liquid chromatography columns and silica-based monolithic trap columns for targeted proteomics.
Sensitivity of renal cell carcinoma to aminoflavone: role of CYP1A1.
Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.
Sequence Polymorphism in Xenobiotic Metabolising Genes in Iraqi Colorectal Cancer Patients.
Serous borderline ovarian tumor with functioning stroma in a postmenopausal woman: immunohistochemical analysis of steroidogenic pathway.
Serum increases CYP1A1 induction by 3-methylcholanthrene.
Serum perfluorooctanoic acid and hepatic enzymes, lipoproteins, and cholesterol: a study of occupationally exposed men.
Serum, plasma and paraffin-embedded tissues as sources of DNA for studying cancer susceptibility genes.
Sex hormone modulation of both induction and inhibition of CYP1A by genistein in HepG2/C3A cells.
Sex- and strain-specific induction of renal tumors by ochratoxin A in rats correlates with DNA adduction.
Sheep gene mapping: assignment of ALDOB, CYP19, WT and SOX2 by somatic cell hybrid analysis.
Sheep lung cytochrome P4501A1 (CYP1A1): cDNA cloning and transcriptional regulation by oxygen tension.
Side effects associated with ultrarapid cytochrome P450 2D6 genotype among women with early stage breast cancer treated with tamoxifen.
Significance of steroidogenic enzymes in the pathogenesis of hyperfunctioning and non-hyperfunctioning adrenal tumor.
Significance of the Minor Cytochrome P450 3A Isoforms.
Significant association between CYP1A1 T3801C polymorphism and cervical neoplasia risk: a systematic review and meta-analysis.
Significant genotype difference in the CYP2E1 PstI polymorphism of indigenous groups in Sabah, Malaysia with Asian and non-Asian populations.
Significant transcriptional down-regulation of the human MDR1 gene by beta-naphthoflavone: a proposed hypothesis linking potent CYP gene induction to MDR1 inhibition.
Silencing TAK1 alters gene expression signatures in bladder cancer cells.
Simple and accurate visual detection of single nucleotide polymorphism based on colloidal gold nucleic acid strip biosensor and primer-specific PCR.
Single or Multiple Access Channels to the CYP450s Active Site? An Answer from Free Energy Simulations of the Human Aromatase Enzyme.
Single-cell analyses of transcriptional heterogeneity in squamous cell carcinoma of urinary bladder.
Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor.
Small agarose microcapsules with cell-enclosing hollow core for cell therapy: Transplantation of ifosfamide-activating cells to the mice with pre-established subcutaneous tumor.
Smoking behavior and related cancers: the role of CYP2A6 polymorphisms.
Smoking out reproductive hormone actions in lung cancer.
Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.
Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients.
Smoking-Related Gene Expression in Laser Capture-Microdissected Human Lung.
SNP analysis combined with protein structure prediction defines structure-functional relationships in cancer related cytochrome P450 estrogen metabolism.
Soy protein isolate and protection against cancer.
Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation.
Spectral Modification and Catalytic Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by Four Chemopreventive Organoselenium Compounds.
Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity.
Steatosis in chronic hepatitis C: association with increased messenger RNA expression of collagen I, tumor necrosis factor-alpha and cytochrome P450 2E1.
Steroid 21-hydroxylase mutations and 21-hydroxylase messenger ribonucleic acid expression in human adrenocortical tumors.
Steroid hormone synthesis by the ovarian stroma surrounding epithelial ovarian tumors: a potential mechanism in ovarian tumorigenesis.
Steroid hormone-dependent overexpression of cytochromes P450 2A in liver tumors of TGF alpha transgenic male mice.
Steroid hormones modulate expression of cytochrome P450 enzymes in male hamster reproductive tract and leiomyosarcomas.
Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis.
Stimulation of Diethylnitrosamine Metabolism Reduces Its General Toxic and Hepatocarcinogenic Effects.
Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment.
Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase.
Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands.
Study of the frequencies of CYP1A1 gene polymorphisms and glutathione S-transferase mu1 gene in primary breast cancers: an update with an additional 114 cases.
Subsieve-size agarose capsules enclosing ifosfamide-activating cells: a strategy toward chemotherapeutic targeting to tumors.
SUMOylation of AhR modulates its activity and stability through inhibiting its ubiquitination.
Sunitinib: new drug. For some gastrointestinal stromal tumours.
Suppression of CYP2C9 by MicroRNA hsa-miR-128-3p in Human Liver Cells and Association with Hepatocellular Carcinoma.
Suppression of hepatic drug metabolism by the interferon inducer, polyriboinosinic acid:polyribocitidylic acid.
Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.
Suppressive effects of caraway (Carum carvi) extracts on 2, 3, 7, 8-tetrachloro-dibenzo-p-dioxin-dependent gene expression of cytochrome P450 1A1 in the rat H4IIE cells.
Suramin: an inhibitor of the final steps of the mineralocorticoid pathway?
Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6.
Susceptibility of C57BL/6 mice to tumorigenicity induced by dimethylnitrosamine and 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine in the neonatal bioassay.
Susceptibility to childhood acute lymphoblastic leukemia: influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 genetic polymorphisms.
Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P450 2E1.
Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender.
Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator.
Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy.
Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.
Synthesis and evaluation of azole-substituted tetrahydronaphthalenes as inhibitors of P450 arom, P450 17, and P450 TxA2.
Synthesis and Evaluation of Novel Cholestanoheterocyclic Steroids as Anticancer Agents.
Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites.
Synthesis and structure-activity relationship studies of ?-naphthoflavone derivatives as CYP1B1 inhibitors.
Synthesis of novel hybrid hetero-steroids: Molecular docking study augmented anti-proliferative properties against cancerous cells.
Synthesis of novel psoralen analogues and their in vitro antitumor activity.
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides.
Synthetic Models Related to Methoxalen and Menthofuran-Cytochrome P450 (CYP) 2A6 Interactions. Benzofuran and Coumarin Derivatives as Potent and Selective Inhibitors of CYP2A6.
T-2 toxin upregulates the expression of human cytochrome P450 1A1 (CYP1A1) by enhancing NRF1 and Sp1 interaction.
Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.
Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue.
Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450.
Targeted delivery of CYP2E1 recombinant adenovirus to malignant melanoma by bone marrow-derived mesenchymal stem cells as vehicles.
Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential.
Targeting cytochrome P450 CYP1B1 with a therapeutic cancer vaccine.
Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development.
Targeting cytochrome P450-dependent cancer cell mitochondria: cancer associated CYPs and where to find them.
Targeting drug-metabolizing enzymes for effective chemoprevention and chemotherapy.
Technology evaluation: MetXia-P450, Oxford Biomedica.
Testicular germ cell tumors exhibit evidence of hormone dependence.
The -omics era and its impact.
The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated.
The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes.
The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver.
The antitumour activity of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole in human gastric cancer models is mediated by AhR signalling.
The Association Between a Functional CYP1A1 Polymorphism and Colorectal Neoplasia Risk in Post Menopausal Women.
The association study between CYP24A1 gene polymorphisms and risk of liver, lung and gastric cancer in a Chinese population.
The associations between CYP24A1 polymorphisms and cancer susceptibility: A meta-analysis and trial sequential analysis.
The Cancer Drug Fraction of Metabolism Database.
The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1.
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.
The chronic spleen injury of mice following long-term exposure to titanium dioxide nanoparticles.
The Consequences of Soluble Epoxide Hydrolase Deletion on Tumorigenesis and Metastasis in a Mouse Model of Breast Cancer.
The contribution of cholesterol and epigenetic changes to the pathophysiology of breast cancer.
The CYP19 TTTA repeat polymorphism is related to the prognosis of premenopausal stage I-II and operable stage III breast cancers.
The CYP1A1 gene and cancer susceptibility.
The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian neoplasms.
The CYP1B1 Leu432Val polymorphism and risk of urinary system cancers.
The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.
The CYP2A6*4 allele is determinant of S-1 pharmacokinetics in Japanese patients with non-small-cell lung cancer.
The CYP2D6 extensive metabolizer genotype is associated with increased risk for bladder cancer.
The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independently of its catalytic activity.
The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.
The cytotoxicity of mitomycin C and adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes.
The down-regulation of the CYP2C19 gene is associated with aggressive tumor potential and the poorer recurrence-free survival of hepatocellular carcinoma.
The effect of cigarette smoke on aryl hydrocarbon hydroxylase activity and cytochrome P450 content in rat liver and lung microsomes.
The effect of exposure to crude oil on the immune system. Health implications for people living near oil exploration activities.
The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk.
The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis.
The Effect of St John's Wort on the Pharmacokinetics of Docetaxel.
The effects of anti-inflammatory agents on skin tumor initiation and aryl hydrocarbon hydroxylase.
The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase.
The effects of benzoflavones on polycyclic hydrocarbon metabolism and skin tumor initiation.
The Effects of Intestinal LPS Exposure on Inflammatory Responses in a Porcine Enterohepatic Co-culture System.
The ERR?-VDR axis promotes calcitriol degradation and estrogen signaling in breast cancer cells, while VDR-CYP24A1-ERR? overexpression correlates with poor prognosis in patients with basal-like breast cancer.
The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer.
The experimental antitumor agents Phortress and doxorubicin are equiactive against human-derived breast carcinoma xenograft models.
The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue.
The Expression Profiles of ADME Genes in Human Cancers and Their Associations with Clinical Outcomes.
The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p.
The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation.
The frequency of cytochrome P450 2E1 polymorphisms in Black South Africans.
The genomics of oral cancer and wound healing.
The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-?B-driven tumour intravasation.
The human immunodeficiency virus protease inhibitor ritonavir is potentially active against urological malignancies.
The immunohistochemical localization of drug-metabolizing enzymes in prostate cancer.
The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen.
The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its metabolites 3-aminobenzanthrone and N-hydroxy-3-aminobenzanthrone in human cells.
The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.
The Inactivation of Human CYP2E1 by Phenethyl Isothiocyanate, a Naturally Occurring Chemopreventive Agent, and Its Oxidative Bioactivation.
The inducible isoform of CREM (inducible cAMP early repressor, ICER) is a repressor of CYP19 rat ovarian promoter.
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
The interleukin-2 receptor down-regulates the expression of cytochrome P450 in cultured rat hepatocytes.
The involvement of secondary signaling molecules in cytochrome P-450 1A1-mediated inducible nitric oxide synthase expression in benzo(a)pyrene-treated rat polymorphonuclear leukocytes.
The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.
The modulatory properties of Si Jun Zi Tang enhancing anticancer of gefitinib by an integrating approach.
The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748.
The overexpression of int-5/Aromatase, a novel MMTV integration locus gene, is responsible for D2 mammary tumor cell proliferation.
The Pathogenic Effects of Fusobacterium nucleatum on the Proliferation, Osteogenic Differentiation, and Transcriptome of Osteoblasts.
The phospholipidosis-lnducing potential of the chemopotentiating drug, N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE, tesmilifene) correlates with its stimulation of phosphatidylserine synthesis and exposure on the plasma membrane in MCF-7 breast cancer cells.
The polymorphism of CYP2E1 Rsa I/Pst I gene and susceptibility to respiratory system cancer: a systematic review and meta-analysis of 34 studies.
The potential role of transcription factor aryl hydrocarbon receptor in downregulation of hepatic cytochrome P-450 during sepsis.
The Preventive Effects of Quercetin on Preterm Birth Based on Network Pharmacology and Bioinformatics.
The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy.
The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction.
The prognostic value of CYP2C subfamily genes in hepatocellular carcinoma.
The prognostic value of differentially expressed CYP3A subfamily members for hepatocellular carcinoma.
The promoter(s) of the aromatase gene in male testicular cells.
The Protective Effects of Water Extracts of Compound Turmeric Recipe on Acute Alcoholism: An Experimental Research Using a Mouse Model.
The PstI/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: a meta-analysis based on 21 case-control studies.
The redox protein thioredoxin-1 regulates the constitutive and inducible expression of the estrogen metabolizing cytochromes P450 1B1 and 1A1 in MCF-7 human breast cancer cells.
The renal medullary thick ascending limb as a model for understanding lipid mediators in sepsis.
The role of aromatase and 17-beta-hydroxysteroid dehydrogenase type 1 mRNA expression in predicting the clinical outcome of human breast cancer.
The role of aryl hydrocarbon hydroxylase in skin tumor initiation by 7,12-dimethylbenz(a)anthracene and 1,2,5,6-dibenzanthracene using DNA binding and thymidine-3H incorporation into DNA as criteria.
The role of COX-2 inhibition in breast cancer treatment and prevention.
The role of CYP2D6*4 variant in bladder cancer susceptibility in Tunisian patients.
The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.
The role of cytochrome P450 in cytotoxic bioactivation: future therapeutic directions.
The role of cytochrome P450 in tumour development and progression and its potential in therapy.
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
The Role of Eicosanoids in Gynecological Malignancies.
The role of epidermal aryl hydrocarbon hydroxylase in the covalent binding of polycyclic hydrocarbon to DNA and its relationship to tumor initiation.
The role of ethnicity in cancer susceptibility gene polymorphisms: the example of CYP1A1.
The role of heterocyclic aromatic amines in colorectal cancer: the evidence from epidemiologic studies.
The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells.
The Selectivity of Austocystin D Arises from Cell-Line-Specific Drug Activation by Cytochrome P450 Enzymes.
The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells.
The synthesis of chalcones as anticancer prodrugs and their bioactivation in CYP1 expressing breast cancer cells.
The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice.
The transcriptomic responses of the ark shell, Anadara broughtonii, to sulfide and hypoxia exposure.
The upregulating effect of dexamethasone on tumor necrosis factor production is mediated by a nitric oxide-producing cytochrome P450.
The use of quantitative histological and molecular data for risk assessment and biologically based model development.
The vitamin D system is deregulated in pancreatic diseases.
The vitamin D/CYP24A1 story in cancer.
Therapeutic-antagonists of oestrogens can be produced for cancer and other therapies using cytochromes P450 (CYP).
Theta class glutathione S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia: interactions with GSTM1, CYP2D6 and smoking.
Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms.
Time and dose-dependent modulation of phase 1 and phase 2 gene expression in response to treatment of MCF-7 cells with a natural anti-cancer agent.
Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein.
Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy.
Tissue-specific induction of the carcinogen inducible cytochrome P450 isoform, P450IAI, in colonic epithelium.
Tobacco smoke as a mouse lung carcinogen.
Tocilizumab: new drug. Rheumatoid arthritis: another 'mab', no therapeutic advantage.
Tolfenamic acid suppresses cytochrome P450 2E1 expression in mouse liver.
Toward individualized treatment: prediction of anticancer drug disposition and toxicity with pharmacogenetics.
Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
Toxic action/toxicity.
Toxicity of antiestrogens.
Toxicogenomic evaluation of liver responses induced by acrylamide and glycidamide in male mouse liver.
Transcript profiling of enzymes involved in detoxification of xenobiotics and reactive oxygen in human normal and simian virus 40 T antigen-immortalized oral keratinocytes.
Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer.
Transcriptome-based identification of new anti-anti-inflammatory and vasodilating properties of the n-3 fatty acid docosahexaenoic acid in vascular endothelial cell under proinflammatory conditions.
Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung.
Trends in co-prescribing of antidepressants and tamoxifen among women with breast cancer, 2004-2010.
Truncal site and detoxifying enzyme polymorphisms significantly reduce time to presentation of further primary cutaneous basal cell carcinoma.
Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction.
Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers.
Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells.
Tumor necrosis factor-alpha activates transcription of inducible repressor form of 3',5'-cyclic adenosine 5'-monophosphate-responsive element binding modulator and represses P450 aromatase and inhibin alpha-subunit expression in rat ovarian granulosa cells by a p44/42 mitogen-activated protein kinase-dependent mechanism.
Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver "stem-like" cells.
Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression.
Tumor promotion by an anticonvulsant agent, phenytoin, in mouse liver: correlation with CYP2B induction.
Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer.
Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.
Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine.
Tumor-selective drug activation: a GDEPT approach utilizing cytochrome P450 1A1 and AQ4N.
Tumor-specific expression of cytochrome P450 CYP1B1.
Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1.
Tumors in brown bullheads in the Chesapeake Bay watershed: analysis of survey data from 1992 through 2006.
Tumour cytochrome P450 and drug activation.
Tumour Microenvironment: Roles of the Aryl Hydrocarbon Receptor, O-GlcNAcylation, Acetyl-CoA and Melatonergic Pathway in Regulating Dynamic Metabolic Interactions across Cell Types-Tumour Microenvironment and Metabolism.
Tumour necrosis factor-? (TNF-?) enhances dietary carcinogen-induced DNA damage in colorectal cancer epithelial cells through activation of JNK signaling pathway.
Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b.
Tumour suppressor protein p53 regulates the stress activated bilirubin oxidase cytochrome P450 2A6.
Typical airborne quinones modulate oxidative stress and cytokine expression in lung epithelial A549 cells.
U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.
Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1.
Understanding Disease-Drug Interactions in Cancer Patients: Implications for Dosing Within the Therapeutic Window.
Unexpected association between induction of immunity to the universal tumor antigen CYP1B1 and response to next therapy.
Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway.
Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients.
Use of cell therapy as a means of targeting chemotherapy to inoperable pancreatic cancer.
Use of duplex PCR-CTPP methods for CYP2E1RsaI/IL-2 T-330G and IL-1B C-31T/TNF-A T-1031C polymorphisms.
Use of proteomics to identify mechanisms of hepatocellular carcinoma with the CYP2D6*10 polymorphism and identification of ANGPTL6 as a new diagnostic and prognostic biomarker.
Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy.
Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads.
Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.
Using bioinformatic approaches to identify pathways targeted by human leukemogens.
Using salmonid microarrays to understand the dietary modulation of carcinogenesis in rainbow trout.
Using the literature-based discovery paradigm to investigate drug mechanisms.
Validation of model of cytochrome P450 2D6: an in silico tool for predicting metabolism and inhibition.
Variant alleles of the CYP1B1 gene are associated with colorectal cancer susceptibility.
Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China.
Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer.
Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors.
VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells.
Venetoclax plus cytochrome P450 inhibitors without ramp-up strategy led to low risk of tumor lysis syndrome in acute myeloid leukemia.
Vincristine pharmacodynamics and pharmacogenetics in children with cancer: A limited-sampling, population modelling approach.
Virilizing oncocytic adrenocortical carcinoma: clinical and immunohistochemical studies.
Vitamin D in Prostate Cancer.
Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG.
Vitamin D Signaling Modulators in Cancer Therapy.
Vitamin D Signaling Pathways Confer the Susceptibility of Esophageal Squamous Cell Carcinoma in a Northern Chinese Population.
Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer.
Weight of evidence evaluation of potential human cancer risks from exposure to polychlorinated biphenyls: an update based on studies published since 2003.
Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A.
Xenobiotic metabolising enzyme expression in colonic neoplasia.
Xenobiotic metabolizing and antioxidant enzymes in normal and neoplastic human breast tissue.
Xenobiotic metabolizing enzymes in genetically and chemically initiated mouse liver tumors.
Xenobiotic-metabolising enzymes in patients with adenocarcinoma of the breast: Correlation with clinical stage and menopausal status.
Xenobiotic-metabolizing enzymes and cancer risk: correspondence between genotype and phenotype.
Xenobiotic-metabolizing enzymes in canine mammary tumours.
Xenobiotics and xenoestrogens in fish: modulation of cytochrome P450 and carcinogenesis.
Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole.
[9-Nitro- and 9-amino-ellipticines and derivatives: synthesis and pharmacologic properties]
[A comparative study of induction regulation in cytochromes family 1 P450 in cell cultures at different stages of tumor transformation]
[Activity and induction of CYP2B, CYP2C, and CYP3A in tissues of cyclophosphane-sensitive and resistant neoplasms and the liver of neoplasm-carrying mice]
[Allelic distribution of the CYP1A1 in lung cancer patients, middle-aged tissue donors and in elderly people without cancer]
[Apoptosis and differentiation induced with TCLA in rat glioblastoma cells in vitro]
[Application of molecular biology to occupational health field--the frequency of gene polymorphism of cytochrome P450 1A1 and glutathione S-transferase M1 in patients with lung, oral and urothelial cancer]
[Association between genetic polymorphisms of metabolic enzymes and susceptibility of colorectal cancer]
[Biological markers and exposure to asbestos]
[Cancer chemotherapy and drug metabolism enzyme]
[Clinical pharmacology and pharmacoepidemiology for medication safety in clinical settings].
[Combined tumor chemotherapy/gene therapy based on the activation of antineoplastic agents by genetic constructions of cytochromes p450]
[Construction of CYP2E1 recombinant adenovirus vector and its anti-tumor effects].
[CYP2E1 gene polymorphism and ovarian cancer risk in the Yakut population].
[Effect of low doses of x-ray irradiation on the liver detoxication system in rats with transplanted Guerin's carcinoma].
[Esthesioneuroblastoma: a case report and literature review]
[Esthesioneuroblastoma].
[EXOPHTHALMOS, EXCEPTIONAL REVELATORY SIGN OF A TUMOR OF THE OLFACTIVE PLACODE. ESTHESIONEUROEPITHELIOMA. HISTOLOGICAL RELATION OF THIS TUMOR TO NERVOUS RETINAL TUMORS.]
[Experimental study on antiendotoxin effect of extracts from Artemisia annua L.]
[Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue]
[Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro].
[First results on the influence of polymorphisms at glutathione S-transferase, cytochrome P450, and tumor necrosis factor gene loci on the development of multiple head and neck cancer]
[Genetic and phenotypic polymorphisms in carcinogen-metabolizing enzymes and cancer susceptibility]
[Genetic polymorphism of steroidogenic enzymes and steroid receptor level in tumors of the reproductive system]
[Genetic polymorphisms of cytochrome P450 2E1 and glutathione S-transferase P1 and susceptibility to esophageal cancer]
[Growth inhibition and multidrug resistance-reversing effect of tanshinone I A on human breast cancer cell with estrogen receptor negative]
[How I was enticed into molecular toxicology]
[Immunologic and genetic markers of exposure to aromatic hydrocarbons in workers].
[Increase of general toxic effects and decrease of hepatocarcinogenic effects of diethylnitrosamine administered to mice in conjunction with isopropanol].
[Influence of genetic polymorphism of CYP1A1 and GSTM1 on the levels of urinary 1-hydroxypyrene]
[Influence of glutathione s-transferase and cytochrome p450 polymorphisms on prognosis of head and neck cancer]
[Inhibitory effect of flavonoids from Scutellariae Radix on human cytochrome P450 1A].
[Interindividual variation of pharmacokinetic disposition of and clinical responses to opioid analgesics in cancer pain patients].
[Malignant tumor's of nasal fossae: anatomoclinic's study and a new classification: study about 21 cases]
[Mechanism of the mutagenic/carcinogenic action of cigarette smoke at the pulmonary level: enzymatic induction, activation and detoxification]
[Multidrug-resistance by induction of inactivation for anti-cancer drugs]
[Perspective technologies for drug design]
[Pharmacokinetic studies on fluorinated pyrimidine in cancer cell and tissue]
[Polymorphisms of CYP1B1 and COMT in breast and endometrial cancer]
[Progress in the study of heterogeneous nuclear ribonucleoprotein and its relation with diseases]
[Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]
[Relationship between the gene polymorphisms of oxidative metabolism enzyme of exogenous chemicals and the susceptibility to neoplasms].
[Research progress on drug metabolism of flavanoids].
[Role of aryl hydrocarbon hydroxylase in developing laryngeal cancer among smokers]
[Study on the relationship between familial clustering of hepatocellular carcinoma and polymorphism of cytochrome P450 2E1 gene in Zhuang population, Guangxi]
[Susceptibility to bronchial cancer: an example of genetic-environmental interaction]
[The enzyme aryl hydrocarbon hydroxylase and its relation to cancer]
[The induction of Guerin's carcinoma cytochrome p450 hydroxylase activity by retinoids].
[The influence of isoflavonoids on the antitumor activity of vitamin D3]
[The strategic use of genetic polymorphisms in carcinogen metabolizing enzyme for prevention of cancer]
[Tumor development and monooxygenase activity in the liver of mice exposed to the combined action of N-nitrosodimethylamine and benz(a)pyrene]
Neoplasms, Germ Cell and Embryonal
Cytochrome P450 aromatase expression in human seminoma.
Risk of testicular germ cell cancer in relation to variation in maternal and offspring cytochrome p450 genes involved in catechol estrogen metabolism.
Neoplasms, Second Primary
Genetic sequence variants in vitamin D metabolism pathway genes, serum vitamin D level and outcome in head and neck cancer patients.
Neoplasms, Squamous Cell
Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue.
Association of cytochrome P450 2E1 polymorphisms and head and neck squamous cell cancer.
Cytochrome P450 1B1, a new keystone in gene-environment interactions related to human head and neck cancer?
Cytochrome p450 and glutathione transferase expression in squamous cell cancer.
Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China.
Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6.
Nephritis, Interstitial
Long-term clinical safety of Clindamycin and Rifampicin combination for the treatment of Hidradenitis suppurativa: a critically appraised topic.
Nephrocalcinosis
1,25-(OH)2D-24 Hydroxylase (CYP24A1) Deficiency as a Cause of Nephrolithiasis.
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
A novel CYP24A1 genotype associated to a clinical picture of hypercalcemia, nephrolithiasis and low bone mass.
A rapid screening of a recurrent CYP24A1 pathogenic variant opens the way to molecular testing for Idiopathic Infantile Hypercalcemia (IIH).
A Young Woman with Recurrent Gestational Hypercalcemia and Acute Pancreatitis Due to CYP24A1 Deficiency.
Calcium and bone homeostasis in heterozygous carriers of CYP24A1 mutations: A cross-sectional study.
CYP24A1 mutation leading to nephrocalcinosis.
Erratum: Medullary nephrocalcinosis in an adult patient with idiopathic infantile hypercalcaemia and a novel CYP24A1 mutation.
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
Idiopathic infantile hypercalcemia: mutations in SLC34A1 and CYP24A1 in two siblings and fathers.
Infantile Nephrocalcinosis Resulting From a Pathogenic CYP24A1 Mutation.
Kidney function and influence of sunlight exposure in patients with impaired 24-hydroxylation of vitamin D due to CYP24A1 mutations.
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Medullary nephrocalcinosis in an adult patient with idiopathic infantile hypercalcaemia and a novel CYP24A1 mutation.
Mutational Spectrum of CYP24A1 Gene in a Cohort of Italian Patients with Idiopathic Infantile Hypercalcemia.
Novel CYP24A1 Mutation in a Young Male Patient with Nephrolithiasis: Case Report.
Re: Loss-of-Function Mutations of CYP24A1, the Vitamin D 24-hydroxylase Gene, Cause Long-standing Hypercalciuric Nephrolithiasis and Nephrocalcinosis.
Successful treatment of hypercalcaemia associated with a CYP24A1 mutation with fluconazole.
The hypercalcaemia of CYP24A1 inactivation: new ways to improve diagnosis and treatment.
VITAMIN D-MEDIATED HYPERCALCEMIA: MECHANISMS, DIAGNOSIS AND TREATMENT.
Nephrolithiasis
1,25-(OH)2D-24 Hydroxylase (CYP24A1) Deficiency as a Cause of Nephrolithiasis.
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
A Case of "Late Onset" Idiopathic Infantile Hypercalcemia Secondary to Mutations in The CYP24A1 Gene.
A Case Report of Compound Heterozygous CYP24A1 Mutations Leading to Nephrolithiasis Successfully Treated with Ketoconazole.
A lifetime of hypercalcemia and hypercalciuria, finally explained.
A novel CYP24A1 genotype associated to a clinical picture of hypercalcemia, nephrolithiasis and low bone mass.
A Young Woman with Recurrent Gestational Hypercalcemia and Acute Pancreatitis Due to CYP24A1 Deficiency.
Clinical and biochemical phenotypes of adults with monoallelic and biallelic CYP24A1 mutations: evidence of gene dose effect.
CYP24A1 loss of function: Clinical phenotype of monoallelic and biallelic mutations.
Erratum to: A novel CYP24A1 genotype associated to a clinical picture of hypercalcemia, nephrolithiasis and low bone mass.
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
Hypercalcemia, Hypercalciuria, and Elevated Calcitriol Concentrations with Autosomal Dominant Transmission Due to CYP24A1 Mutations: Effects of Ketoconazole Therapy.
Iatrogenic vitamin D toxicity in an infant - a case report and review of literature.
LC-MS/MS for Identifying Patients with CYP24A1 Mutations.
Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Mutational Spectrum of CYP24A1 Gene in a Cohort of Italian Patients with Idiopathic Infantile Hypercalcemia.
Novel CYP24A1 Mutation in a Young Male Patient with Nephrolithiasis: Case Report.
Re: Loss-of-Function Mutations of CYP24A1, the Vitamin D 24-hydroxylase Gene, Cause Long-standing Hypercalciuric Nephrolithiasis and Nephrocalcinosis.
Single-nucleotide polymorphisms in the UDP-glucuronosyltransferase 1A-3' untranslated region are associated with atazanavir-induced nephrolithiasis in patients with HIV-1 infection: a pharmacogenetic study.
Successful treatment of hypercalcaemia associated with a CYP24A1 mutation with fluconazole.
Therapy-Resistant Hypercalcemia in a Patient with Inactivating CYP24A1 Mutation and Recurrent Nephrolithiasis: Beware of Concomitant Hyperparathyroidism.
VITAMIN D-MEDIATED HYPERCALCEMIA: MECHANISMS, DIAGNOSIS AND TREATMENT.
Nephrosis
Contribution of down-regulation of intestinal and hepatic cytochrome P450 3A to increased absorption of cyclosporine A in a rat nephrosis model.
Nephrotic Syndrome
Correction to: CYP3A5 and CYP3A7 genetic polymorphisms affect tacrolimus concentration in pediatric patients with nephrotic syndrome.
Cytochrome P450 2B1 mediates oxidant injury in puromycin-induced nephrotic syndrome.
Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells.
Diltiazem on tacrolimus exposure and dose sparing in Chinese pediatric primary nephrotic syndrome: impact of CYP3A4, CYP3A5, ABCB1, and SLCO1B3 polymorphisms.
Dosage Optimization Based on Population Pharmacokinetic Analysis of Tacrolimus in Chinese Patients with Nephrotic Syndrome.
Impaired testicular cytochrome P450 side-chain-cleavage (P450scc) and steroidogenic acute regulatory (StAR) protein expression in rats with nephrotic syndrome.
MDR-1 and CYP3A5 Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome: Impact on Susceptibility and Response to Steroids (Preliminary Results).
Optimization of initial dosing scheme of tacrolimus in pediatric refractory nephrotic syndrome patients based on CYP3A5 genotype and coadministration with wuzhi-capsule.
Steroidogenic impairment due to reduced ovarian transcription of cytochrome P450 side-chain-cleavage (P450scc) and steroidogenic acute regulatory protein (StAR) during experimental nephrotic syndrome.
Nervous System Diseases
Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders.
Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene.
Psychotropic drugs and CYP2D6 in late-life psychiatric and neurological disorders. What do we know?
[Acquired long QT syndrome: a dominant problem?]
Neural Tube Defects
Pharmacogenetic screening for susceptibility to fetal malformations in women.
Neuralgia
Drug interactions in human neuropathic pain pharmacotherapy.
Effects of type 1 and type 2 diabetes on the pharmacokinetics of tramadol enantiomers in patients with neuropathic pain phenotyped as cytochrome P450 2D6 extensive metabolizers.
Impact of fraction unbound, CYP3A, and CYP2D6 in vivo activities, and other potential covariates to the clearance of tramadol enantiomers in patients with neuropathic pain.
Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.
Severe Vincristine-induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study.
The gene regulatory network in different brain regions of neuropathic pain mouse models.
[Clinical pharmacology of medical cannabinoids in chronic pain].
[Desvenlafaxine and neuropathic pain: additional clinical benefits of a second generation serotonin-noradrenaline reuptake inhibitor].
Neuralgia, Postherpetic
CYP2D6*4 polymorphism, tramadol treatment and its clinical impact in patients with postherpetic neuralgia.
Neurilemmoma
Tissue-specific expression and methylation of the human CYP2E1 gene.
[Intracranial Rosai-Dorfman disease mimicking multiple meningiomas].
Neuroblastoma
?-Naphtoflavone and Ethanol Induce Cytochrome P450 and Protect towards MPP? Toxicity in Human Neuroblastoma SH-SY5Y Cells.
Acetaminophen induces human neuroblastoma cell death through NFKB activation.
Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics.
Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells.
Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells.
P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models.
[Esthesioneuroblastoma: a case report and literature review]
Neurocysticercosis
Albendazole metabolism in patients with neurocysticercosis: antipyrine as a multifunctional marker drug of cytochrome P450.
Neurodegenerative Diseases
?-Naphthoflavone and Ethanol Reverse Mitochondrial Dysfunction in A Parkinsonian Model of Neurodegeneration.
ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders.
APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population.
Brain aromatase is neuroprotective.
Brain sterol flux mediated by cytochrome P450 46A1 affects membrane properties and membrane-dependent processes.
CYP7B1: novel mutations and magnetic resonance spectroscopy abnormalities in hereditary spastic paraplegia type 5A.
Cytochrome P450 eicosanoids in cerebrovascular function and disease.
Cytochrome P450 in neurological disease.
Cytochrome P450 in the central nervous system as a therapeutic target in neurodegenerative diseases.
Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.
Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo.
Excretion, Metabolism and Cytochrome P450 Inhibition of Methyl 3,4-Dihydroxybenzoate (MDHB): A Potential Candidate to Treat Neurodegenerative Diseases.
Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice.
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration.
Localization of NADPH cytochrome P450 oxidoreductase in rat brain by immunohistochemistry and in situ hybridization and a comparison with the distribution of neuronal NADPH-diaphorase staining.
Metabolism of xenobiotics in the central nervous system: implications and challenges.
The lack of Irs2 induces changes in the immunocytochemical expression of aromatase in the mouse retina.
Neurofibromatoses
Debrisoquine hydroxylase gene polymorphism in neurofibromatosis type 1.
Neurofibromatosis 2
Debrisoquine hydroxylase gene polymorphism in neurofibromatosis type 1.
Neuroinflammatory Diseases
Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice.
Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases.
Cytochrome P450 eicosanoids in cerebrovascular function and disease.
Neuroinflammation is able to downregulate cytochrome P450 epoxygenases 2J3 and 2C11 in the rat brain.
Neuroleptic Malignant Syndrome
A case study: neuroleptic malignant syndrome with risperidone and CYP2D6 gene variation.
CYP2D6 gene deletion allele in patients with neuroleptic malignant syndrome: preliminary report.
CYP2D6 genotype and possible susceptibility to the neuroleptic malignant syndrome.
CYP2D6 HhaI genotype and the neuroleptic malignant syndrome.
CYP2D6 Hhal genotype and the neuroleptic malignant syndrome (NMS)
Effects of CYP2D6 polymorphisms on neuroleptic malignant syndrome.
Lack of association in Japanese patients between neuroleptic malignant syndrome and a debrisoquine 4-hydroxylase genotype with low enzyme activity.
Mutation involving cytochrome P450IID6 in two Japanese patients with neuroleptic malignant syndrome.
Neuroleptic malignant syndrome and hydroxylase gene mutations: no association with CYP2D6A or CYP2D6B.
Neuroleptic malignant syndrome in an adolescent with CYP2D6 deficiency.
Neurologic Manifestations
c.1263+1G>A Is a Latent Hotspot for CYP27A1 Mutations in Chinese Patients With Cerebrotendinous Xanthomatosis.
Cerebrotendinous Xanthomatosis ataxia responsive to CDCA and Riluzole.
Chenodeoxycholic Acid: An Update on Its Therapeutic Applications.
Neuroma, Acoustic
Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors.
Neutropenia
A physiologically based pharmacokinetic - pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug-drug interactions of paclitaxel in cancer patients.
Comparison of docetaxel/cisplatin dosages of 75/60 and 60/60 mg/m(2) for the treatment of non-small cell lung cancer.
Dose-finding study on adjuvant chemotherapy with S-1 plus oxaliplatin for gastric cancer.
Drug-related genetic polymorphisms affecting severe chemotherapy-induced neutropenia in breast cancer patients: A hospital-based observational study.
Pharmacogenetic determinants of outcomes on triplet hepatic artery infusion and intravenous cetuximab for liver metastases from colorectal cancer (European trial OPTILIV, NCT00852228).
Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6.
Pretreatment H2 receptor antagonists that differ in P450 modulation activity: comparative effects on paclitaxel clearance rates and neutropenia.
Prospective evaluation of the drug-metabolizing enzyme polymorphisms and toxicity profile of docetaxel in Korean patients with operable lymph node-positive breast cancer receiving adjuvant chemotherapy.
Randomized pharmacokinetic and pharmacodynamic study of docetaxel: dosing based on body-surface area compared with individualized dosing based on cytochrome P450 activity estimated using a urinary metabolite of exogenous cortisol.
Role of pharmacogenetics on adjuvant chemotherapy-induced neutropenia in Chinese breast cancer patients.
[Validation of genetic polymorphisms associated to the toxicity of chemotherapy in colorectal cancer patients].
Nevus
CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
Nevus, Pigmented
CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.
Non-alcoholic Fatty Liver Disease
A case-control study on the effect of metabolic gene polymorphisms, nutrition, and their interaction on the risk of non-alcoholic fatty liver disease.
A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.
A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma.
A novel sesquiterpene glycoside from Loquat leaf alleviates oleic acid-induced steatosis and oxidative stress in HepG2 cells.
A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease.
Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Bariatric surgery-induced weight loss reduces hepatic lipid peroxidation levels and affects hepatic cytochrome P-450 protein content.
Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation.
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model.
CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
CYP2E1 and Oxidant Stress in Alcoholic and Non-Alcoholic Fatty Liver Disease.
CYP3A suppression during diet-induced nonalcoholic fatty liver disease is independent of PXR regulation.
Cytochrome P450 1A1 (CYP1A1) Catalyzes Lipid Peroxidation of Oleic Acid-Induced HepG2 Cells.
Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice.
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications.
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis.
Diet-induced non-alcoholic fatty liver disease affects expression of major cytochrome P450 genes in a mouse model.
Effect of Chinese Herbal Monomer Hairy Calycosin on Nonalcoholic Fatty Liver Rats and its Mechanism.
Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA?treated HepG2 cells.
Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet.
Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model.
Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice.
Establishment of an ex Vivo Model of Nonalcoholic Fatty Liver Disease Using a Tissue-Engineered Liver.
Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation.
Expression of Cytochrome P450 2A5 in a C57BL/6J Mouse Model of Nonalcoholic Fatty Liver Disease.
Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress.
Gender differences in diet-induced steatotic disease in Cyp2b-null mice.
Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.
Hepatic cytochrome P450 2E1 activity in nonalcoholic fatty liver disease.
Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis.
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis.
Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.
Hepatic Lipid Peroxidation and Cytochrome P-450 2E1 in Pediatric Nonalcoholic Fatty Liver Disease and Its Subtypes.
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.
Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat.
Hepatoprotective Effect of Loquat Leaf Flavonoids in PM2.5-Induced Non-Alcoholic Fatty Liver Disease via Regulation of IRs-1/Akt and CYP2E1/JNK Pathways.
Hepatoprotective Effect of Seed Coat ofEuryale ferox Extract in Non-alcoholic Fatty Liver Disease Induced by High-fat Diet in Mice by Increasing IRs-1 and Inhibiting CYP2E1.
High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model.
Higher chlorzoxazone clearance in obese children compared with nonobese peers.
Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis.
Importance of genetic polymorphisms in liver transplantation outcomes.
In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice.
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role.
Influence of royal jelly on mouse hepatic gene expression and safety assessment with a DNA microarray.
Integrated analysis of hepatic mRNA and miRNA profiles identified molecular networks and potential biomarkers of NAFLD.
Investigation of nonalcoholic fatty liver disease-induced drug metabolism by comparative global toxicoproteomics.
Molecular pathways involved in the improvement of non-alcoholic fatty liver disease.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
New insight and potential therapy for NAFLD: CYP2E1 and flavonoids.
NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity.
Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters.
Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model.
Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Cytochrome P450 (CYP) Enzymes.
Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease.
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients.
Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis.
Pharmacological Mechanisms Underlying the Hepatoprotective Effects of Ecliptae herba on Hepatocellular Carcinoma.
Pioglitazone, quercetin and hydroxy citric acid effect on cytochrome P450 2E1 (CYP2E1) enzyme levels in experimentally induced non alcoholic steatohepatitis (NASH).
Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein.
Protective effect and mechanism of Qiwei Tiexie capsule on 3T3-L1 adipocytes cells and rats with nonalcoholic fatty liver disease by regulating LXR?, PPAR?, and NF-?B-iNOS-NO signaling pathways.
Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation.
Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis.
Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease.
Regulation of the cytochrome P450 epoxyeicosanoid pathway is associated with distinct histologic features in pediatric non-alcoholic fatty liver disease.
Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients.
Relevance of CYP2E1 to Non-alcoholic Fatty Liver Disease.
Role of CYP2E1 in mitochondrial dysfunction and hepatic tissue injury in alcoholic and non-alcoholic diseases.
Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women.
Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD.
Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers.
TA allele of rs2070673 in the CYP2E1 gene is associated with lobular inflammation and nonalcoholic steatohepatitis in patients with biopsy-proven nonalcoholic fatty liver disease.
Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice.
Targeting CYP4A attenuates hepatic steatosis in a novel multicellular organotypic liver model.
The 13C-Caffeine Breath Test Detects Significant Fibrosis in Patients With Nonalcoholic Steatohepatitis.
The CYP2E1 knockout delivers another punch: first ASH, now NASH. Alcoholic steatohepatitis. Nonalcoholic steatohepatitis.
The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.
The generation of carcinogenic etheno-DNA adducts in the liver of patients with nonalcoholic fatty liver disease.
The preventive effect of phenolic-rich extracts from Chinese sumac fruits against nonalcoholic fatty liver disease in rats induced by a high-fat diet.
Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease.
Tobacco Smoke and CYP1A2 Activity in a US Population with Normal Liver Enzyme Levels.
Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition.
Transcriptional Repression of CYP3A4 by Increased miR-200a-3p and miR-150-5p Promotes Steatosis in vitro.
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models.
[Experimental study on inhibitory effect of Chinese herbal compound on hepatocyte cytochrome P450 II E1 expression in rat model of nonalcoholic fatty liver]
[Influence of electroacupuncture on hepatic cytochrome P450 1 A 1 expression and lipid peroxidation in nonalcoholic fatty liver rats]
[The role of cytochrome P450 in nonalcoholic fatty liver induced by high-fat diet: a gene expression profile analysis].
Non-ST Elevated Myocardial Infarction
Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) registry.
Letter by Hnid and Chtioui regarding article, "Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Registry".
Obesity
A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity.
A genetic polymorphism in the regulatory sequences of human CYP2E1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake.
Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect.
ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects.
Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome.
Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion.
Altered cytochrome P450 activities and expression levels in the liver and intestines of the monosodium glutamate-induced mouse model of human obesity.
Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.
Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis.
Caffeine disposition in obesity.
Characterization of cytochrome P450 and glutathione S-transferase activity and expression in male and female ob/ob mice.
Characterization of hepatic cytochrome P450 isozyme composition in the transgenic rat expressing low level human growth hormone.
Characterization of the amino acid adducts of the enedial derivative of teucrin A.
Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study.
Comparing the protective effects of three sulfur compounds against acrylonitrile-induced acute toxicity in CYP2E1-induced rats.
Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice.
CYP1B1 deficiency ameliorates obesity and glucose intolerance induced by high fat diet in adult C57BL/6J mice.
CYP1B1 deiciency ameliorates learning and memory deficits caused by high fat diet in mice.
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model.
Cyp2b-Knockdown Mice Poorly Metabolize Corn Oil and Are Age-Dependent Obese.
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.
CYP2E1 activity and children with obesity: possible confounding factors.
CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
CYP2E1 autoantibodies in liver diseases.
CYP2E1 Impairs GLUT4 Gene Expression and Function: NRF2 as a Possible Mediator.
CYP2E1 potentiates toxicity in obesity and after chronic ethanol treatment.
CYP2E1 RsaI and 96-bp insertion genetic polymorphisms associated with risk for colorectal cancer.
CYP450 activities before and after Roux-en-Y gastric bypass: correlation with their intestinal and liver content.
CYP450, COX-2 and Obesity Related Renal Damage.
Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance.
Cytochrome P450 2E1 (CYP2E1) positively regulates lipid catabolism and induces browning in 3T3-L1 white adipocytes.
Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.
Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat.
Dietary-Induced Obesity, Hepatic Cytochrome P450, and Lidocaine Metabolism: Comparative Effects of High-Fat Diets in Mice and Rats and Reversibility of Effects With Normalization of Diet.
Differences in Early Acetaminophen Hepatotoxicity between Obese ob/ob and db/db Mice.
Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.
Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity.
Effect of genetic obesity and experimental diabetes on hepatic microsomal mixed function oxidase activities.
Effect of nutritional obesity on the induction of CYP2B enzymes following phenobarbital treatment.
Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice.
Effects of obesity on liver cytochromes P450 in various animal models.
Effects of obesity on pharmacokinetics implications for drug therapy.
Effects of obesity on the cytochrome P450 enzyme system.
Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation.
Evaluation of the Associations of GC and CYP2R1 Genes and Gene-Obesity Interactions with Type 2 Diabetes Risk in a Chinese Rural Population.
Expression of a male-specific cytochrome P450 isozyme (CYP2C11) in fa/fa Zucker rats: effect of phenobarbital treatment.
Expression of the CYP3A and CYP2C11 enzymes in a nutritionally obese rodent model: response to phenobarbital treatment.
Extracting time-dependent obese-diabetic specific networks in hepatic proteome analysis.
Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity.
Genetic association analysis of vitamin D pathway with obesity traits.
Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells.
Genetic polymorphisms and obesity influence estradiol decline during the menopause.
Haplotypes of CYP1B1 and CCDC57 genes in an Afro-Caribbean female population with uterine leiomyoma.
High-Fat Diet Feeding Alters Expression of Hepatic Drug-Metabolizing Enzymes in Mice.
Higher chlorzoxazone clearance in obese children compared with nonobese peers.
Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis.
Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals.
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role.
Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice.
Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK.
Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides.
Lipidomics Reveals a Link between CYP1B1 and SCD1 in Promoting Obesity.
Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition.
Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity.
Microduplication of 10q26.3 in a Chinese hypertriglyceridemia patient.
Midazolam pharmacokinetics in morbidly obese patients following semi-simultaneous oral and intravenous administration: a comparison with healthy volunteers.
Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma.
Non-alcoholic Steatohepatitis (NASH) Drug Discovery - Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development.
Nonesterified fatty acids in the pathogenesis of hypertension: theory and evidence.
Obesity alters the ovarian proteomic response to zearalenone exposure†.
Obesity and fatty liver are prevented by inhibition of the aryl hydrocarbon receptor in both female and male mice.
Obesity and Inflammation and Altered Clopidogrel Pharmacokinetics and Pharmacodynamics.
Obesity and Insulin Resistance: Associations with Chronic Inflammation, Genetic and Epigenetic Factors.
Obesity as a risk factor for drug-induced organ injury. VI. Increased hepatic P450 concentration and microsomal ethanol oxidizing activity in the obese overfed rat.
Obesity during pregnancy affects sex steroid concentrations depending on fetal gender.
Obesity is associated with a slower response to initial phenprocoumon therapy whereas CYP2C9 genotypes are not.
Obesity Represses CYP2R1, the Vitamin D 25-Hydroxylase, in the Liver and Extrahepatic Tissues.
Overexpression of cholesterol 7?-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis.
Permanent uncoupling of male-specific CYP2C11 transcription/translation by perinatal glutamate.
Pharmacokinetics and metabolism of natural methylxanthines in animal and man.
Pharmacokinetics in Morbid Obesity: Influence of Two Bariatric Surgery Techniques on Paracetamol and Caffeine Metabolism.
Potential role of aryl hydrocarbon receptor signaling in childhood obesity.
Potential role of CYP1B1 in the development and treatment of metabolic diseases.
Progressive obesity alters ovarian insulin, phosphatidylinositol-3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by phosphoramide mustard in mice.
Progressive obesity alters ovarian insulin, phosphatidylinositol-3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by phosphoramide mustard in mice†.
Research Progress on the Relationship between Obesity-Inflammation-Aromatase Axis and Male Infertility.
Reversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPAR?, SCD1, and osteopontin.
Role of CYP2E1 in mitochondrial dysfunction and hepatic tissue injury in alcoholic and non-alcoholic diseases.
Steatohepatitis induced by intragastric overfeeding in mice.
Sterol 27-Hydroxylase Polymorphism Significantly Associates With Shorter Telomere, Higher Cardiovascular and Type-2 Diabetes Risk in Obese Subjects.
Tacrolimus Exposure in Obese Patients: A Case-Control Study in Kidney Transplantation.
The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.
The effect of obesity on the ratio of type 3 17beta-hydroxysteroid dehydrogenase mRNA to cytochrome P450 aromatase mRNA in subcutaneous abdominal and intra-abdominal adipose tissue of women.
The effect of obesity, macronutrients, fasting and nutritional status on drug-metabolizing cytochrome P450s: a systematic review of current evidence on human studies.
The Influence of Obesity on the Pharmacokinetics of Dioxin in Mice: An Assessment Using Classical and PBPK Modeling.
The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases.
The role of oestrogen in the pathogenesis of obesity, type 2 diabetes, breast cancer and prostate disease.
Transcriptome Analysis of Testis from HFD-Induced Obese Rats (Rattus norvigicus) Indicated Predisposition for Male Infertility.
Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease.
Undernutrition during hyperoxic exposure induces CYP2E1 in rat liver.
Vitamin D pathway-related gene polymorphisms and their association with metabolic diseases: A literature review.
Vitamin paradox in obesity: Deficiency or excess?
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models.
[Genetic aspects of polycystic ovary syndrome]
[Perfusion and metabolism of liver and splanchnic nerve area under sevoflurane anesthesia]
Obesity, Abdominal
Association of cytochrome P450 1B1 gene polymorphisms and environmental biomarkers with hypertension in Slovak midlife women.
Relationship Between Amounts of Daily Cigarette Consumption and Abdominal Obesity Moderated by CYP2A6 Genotypes in Chinese Male Current Smokers.
The CYP19 gene and associations with androgens and abdominal obesity in premenopausal women.
Obesity, Maternal
Maternal obesity alters feto-placental cytochrome P4501A1 activity.
Obesity, Morbid
CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity.
Short- and medium-term impact of bariatric surgery on the activities of CYP2D6, CYP3A4, CYP2C9, and CYP1A2 in morbid obesity.
Obstetric Labor, Premature
Nifedipine Pharmacokinetics Are Influenced by CYP3A5 Genotype When Used as a Preterm Labor Tocolytic.
Occupational Diseases
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Decreased Cyp2E1 mRNA expression in human leucocytes in patients with fibrotic and inflammatory lung diseases.
Ocular Hypertension
Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma.
Survey of familial glaucoma shows a high incidence of cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) mutations in non-consanguineous congenital forms in a Spanish population.
Oligodendroglioma
Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target.
Oligospermia
[Genetic genes associated with oligospermia, asthenospermia and teratospermia: Advances in studies].
Onchocerciasis
Genetic polymorphisms in MDR1, CYP3A4 and CYP3A5 genes in a Ghanaian population: a plausible explanation for altered metabolism of ivermectin in humans?
Opioid-Induced Constipation
Simulation and Prediction of the Drug-Drug Interaction Potential of Naloxegol by Physiologically Based Pharmacokinetic Modeling.
Opisthorchiasis
Andrographolide Ameliorates Beta-Naphthoflavone-Induced CYP1A Enzyme Activity and Lipid Peroxidation in Hamsters with Acute Opisthorchiasis.
Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini.
Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts.
Opportunistic Infections
Delavirdine: a review of its use in HIV infection.
Interactions between recreational drugs and antiretroviral agents.
Optic Atrophy
Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy.
Oral Submucous Fibrosis
Association of CYP1A1, GSTM1, and GSTT1 gene polymorphism with risk of oral submucous fibrosis in a section of North Indian population.
CYP1AI and CYP2E1 gene polymorphisms may increase susceptibility to Oral Submucous Fibrosis among betel quid chewers of Eastern India.
Novel genetic biomarkers for susceptibility to oral submucous fibrosis: cytochrome P450 3A.
Roles of CYP1A1 and CYP2E1 Gene Polymorphisms in Oral Submucous Fibrosis.
[Expression of cytochrome P450 related genes in oral submucous fibrosis tissue].
[Expression of loricrin and cytochrome P450 3A5 in oral submucous fibrosis and their significance]
Oral Ulcer
Respiratory, cardiovascular and other physiological consequences of smoking cessation.
Oropharyngeal Neoplasms
Oral and oropharyngeal cancer, aryl hydrocarbon hydroxylase inducibility and smoking. A follow-up study.
Osteoarthritis
PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata.
Osteomalacia
Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D(3) through CYP3A4 induction in vitro and in vivo: Implications for drug-induced osteomalacia.
Osteomalacia in an HIV-infected man receiving rifabutin, a cytochrome P450 enzyme inducer: a case report.
Osteomyelitis
[The state of the microsomal oxidative system in the liver of rats with acute osteomyelitis of the mandible]
Osteonecrosis
A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer.
Association between CYP2C8 (rs1934951) Polymorphism and Bisphosphonate-Related Osteonecrosis of the Jaws in Patients on Bisphosphonate Therapy: A Meta-Analysis.
Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis.
CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma.
Low hepatic cytochrome P450 3A activity is a risk for corticosteroid-induced osteonecrosis.
Low levels of steroid-metabolizing hepatic enzyme (cytochrome P450 3A) activity may elevate responsiveness to steroids and may increase risk of steroid-induced osteonecrosis even with low glucocorticoid dose.
The effects of P-gp and CYP450 modulated by rifampicin on the steroid-induced osteonecrosis of the femoral head.
Osteoporosis
A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome.
A polymorphic CYP19 TTTA repeat influences aromatase activity and estrogen levels in elderly men: effects on bone metabolism.
Association of CYP1A1 and CYP1B1 polymorphisms with bone mineral density variations in postmenopausal Mexican-Mestizo women.
Association of serum sex steroid levels and bone mineral density with CYP17 and CYP19 gene polymorphisms in postmenopausal women in Turkey.
Contribution of genetic variations in estradiol biosynthesis and metabolism enzymes to osteoporosis.
CYP2C9 genotype and association with bone mineral density: a pilot study.
Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density.
Elimination of major side effects due to ROS of therapeuticals through biotransformation control of the 57 cytochromes P450 isoenzymes.
Functional Analyses of Four CYP1A1 Missense Mutations Present in Patients with Atypical Femoral Fractures.
Genome-wide association with bone mass and geometry in the Framingham Heart Study.
In silico identification and screening of CYP24A1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis.
Incidence of Mutations in the ALPL, GGPS1, and CYP1A1 Genes in Patients With Atypical Femoral Fractures.
Multilocus analysis of estrogen-related genes in Spanish postmenopausal women suggests an interactive role of ESR1, ESR2 and NRIP1 genes in the pathogenesis of osteoporosis.
Optimal management of peptic ulcer disease in the elderly.
Polymorphisms in the CYP19 and AR genes--relation to bone mass and longitudinal bone changes in postmenopausal women with or without hormone replacement therapy: The Danish Osteoporosis Prevention Study.
Preventing Cushing: Iatrogenic Cushing Syndrome due to Ritonavir-Fluticasone Interaction.
The role of estrogen receptor-alpha gene TA polymorphism and aromatase gene TTTA polymorphism on peak bone mass attainment in males: is there an additive negative effect of certain allele combinations?
The Val432Leu polymorphism of the CYP1B1 gene is associated with differences in estrogen metabolism and bone density.
Osteosarcoma
Analysis of Drug Metabolizing Gene Panel in Osteosarcoma Patients Identifies Association Between Variants in SULT1E1, CYP2B6 and CYP4F8 and Methotrexate Levels and Toxicities.
Cas9 Protein Triggers Differential Expression of Inherent Genes Especially NGFR Expression in 293T Cells.
Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma.
Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines.
Expression of the aryl hydrocarbon receptor pathway and cyclooxygenase-2 in dog tumors.
Identification of co-expression modules and pathways correlated with osteosarcoma and its metastasis.
Identification of genetic variants in pharmacokinetic genes associated with Ewing Sarcoma treatment outcome.
Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Otitis
Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions.
Ototoxicity
CYP Genotypes Are Associated with Toxicity and Survival in Osteosarcoma Patients.
Ovarian Cysts
Hypothalamic-pituitary-ovarian axis during infancy, early and late prepuberty in an aromatase-deficient girl who is a compound heterocygote for two new point mutations of the CYP19 gene.
Ovarian Diseases
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis.
Ovarian Hyperstimulation Syndrome
Modulation of steroidogenesis by vitamin D3 in granulosa cells of the mouse model of polycystic ovarian syndrome.
Ovarian Neoplasms
Analysis of Over 10,000 Cases Finds No Association between Previously-Reported Candidate Polymorphisms and Ovarian Cancer Outcome.
Association of caffeine intake and CYP1A2 genotype with ovarian cancer.
Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer.
Case-control study of ovarian cancer and polymorphisms in genes involved in catecholestrogen formation and metabolism.
CYP1A1 alleles in female genital cancers in the Polish population.
CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm.
CYP1A1 Ile(462)Val is a risk factor for ovarian cancer development.
CYP1B1 determines susceptibility to low doses of 7,12-dimethylbenz[a]anthracene-induced ovarian cancers in mice: correlation of CYP1B1-mediated DNA adducts with carcinogenicity.
CYP1B1 expression in ovarian cancer in the laying hen Gallusdomesticus.
CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKC? activation and phosphorylation of XIAP.
Cytochrome P1B1 (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis.
Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: a meta-analysis.
Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer.
Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies.
Estradiol 17? and Its Metabolites Stimulate Cell Proliferation and Antagonize Ascorbic Acid-Suppressed Cell Proliferation in Human Ovarian Cancer Cells.
Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a mouse ovarian cancer cell line.
Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells.
Genetic variation in ABCB1 influences paclitaxel pharmacokinetics in Japanese patients with ovarian cancer.
Host CYP27A1 expression is essential for ovarian cancer progression.
Interaction between CYP1A1 polymorphic variants and dietary exposures influencing ovarian cancer risk.
Knockdown of CYP24A1 Aggravates 1?,25(OH)2D3-Inhibited Migration and Invasion of Mouse Ovarian Epithelial Cells by Suppressing EMT.
Metabolic behavior prediction of pazopanib by cytochrome P450 (CYP) 3A4 by molecular docking.
Ovarian cancer risk and polymorphisms involved in estrogen catabolism.
Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis.
Oxidative Stress and Antioxidant Defense in Endometriosis and Its Malignant Transformation.
Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer.
Pharmacogenetic studies of Paclitaxel in the treatment of ovarian cancer.
Pharmacokinetics of paclitaxel in ovarian cancer patients and genetic polymorphisms of CYP2C8, CYP3A4, and MDR1.
Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1.
Polymorphisms in ABCB1 and ERCC2 associated with ovarian cancer outcome.
Polymorphisms of
Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
Progestins inhibit calcitriol-induced CYP24A1 and synergistically inhibit ovarian cancer cell viability: An opportunity for chemoprevention.
Refinement of an ovarian cancer tumour suppressor gene locus on chromosome arm 22q and mutation analysis of CYP2D6, SREBP2 and NAGA.
Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4'-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells.
The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian neoplasms.
The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity.
The ovarian carcinoma risk with the polymorphisms of CYP1B1 come from the positive selection.
The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKC? signaling.
Unbalanced estrogen metabolism in ovarian cancer.
Validation of PCR-RFLP techniques for the evaluation of codon 72 of p53 and CYP1A1 gene's polymorphisms in relation with ovarian cancer in a Romanian population.
Whole genome expression profiling of blood cells in ovarian cancer patients -prognostic impact of the CYP1B1, MTSS1, NCALD, and NOP14.
[CYP2E1 gene polymorphism and ovarian cancer risk in the Yakut population].
[Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro].
Overweight
Cephalic phase insulin secretion in relation to food presentation in normal and overweight subjects.
Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women.
Short- and medium-term impact of bariatric surgery on the activities of CYP2D6, CYP3A4, CYP2C9, and CYP1A2 in morbid obesity.
[Variability in the frequency of TCR-mutant lymphocytes associated with gene polymorphisms in women living in radiation-polluted areas].
Ovotesticular Disorders of Sex Development
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
Pancreatic Diseases
Differences in immunohistochemical expression of xenobiotic-metabolizing enzymes between normal pancreas, chronic pancreatitis and pancreatic cancer.
Pancreatic Neoplasms
Contribution of environment and genetics to pancreatic cancer susceptibility.
CYP1B1 gene polymorphism modifies pancreatic cancer risk but not survival.
CYP1B1 Polymorphisms and K-ras Mutations in Patients with Pancreatic Ductal Adenocarcinoma.
CYP3A5 Drives Intrinsic and Acquired Resistance in Pancreatic Cancer.
Differences in immunohistochemical expression of xenobiotic-metabolizing enzymes between normal pancreas, chronic pancreatitis and pancreatic cancer.
Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer.
Genetic variants in vitamin d pathway genes and risk of pancreas cancer; results from a population-based case-control study in ontario, Canada.
Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.
Pacinian corpuscle in the human pancreas.
Pancreatic cancer: CYP3A5 contributes to PDAC chemoresistance.
Phenotypic CYP2A6 variation and the risk of pancreatic cancer.
Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma.
Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.
Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis.
Targeting the CYP2B 1/cyclophosphamide suicide system to fibroblast growth factor receptors results in a potent antitumoral response in pancreatic cancer models.
The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748.
Vitamin D metabolic pathway genes and pancreatic cancer risk.
Pancreatitis
A Young Woman with Recurrent Gestational Hypercalcemia and Acute Pancreatitis Due to CYP24A1 Deficiency.
Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals.
Genetic polymorphism of CYP2E1 and digestive tract alcohol damage among Polish individuals.
Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in Japan.
Genotypes of Alcohol-Metabolizing Enzymes in Relation to Alcoholic Chronic Pancreatitis in Japan.
Hypercalcemic Pancreatitis Triggered by Pregnancy With a CYP24A1 Mutation.
Occupational chemicals and pancreatitis: a link?
Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics.
Statins and their role in acute pancreatitis: Case report and literature review.
[Change in the rat liver microsomal monooxygenase system upon induction with phenobarbital in acute pancreatitis]
[Changes in the microsomal monooxygenase system of the rat liver in acute pancreatitis and during induction by Aroclor 1254]
[Protective effect of fructus gardeniae on pancreatic subcellular organs of the acute pancreatitis in rats]
[Remote effects of Aroclor 1254 on the rat liver microsomal monooxygenase activity in acute pancreatitis]
[Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs].
Pancreatitis, Alcoholic
Association between genetic variants in CYP2E1 and CTRC genes and susceptibility to alcoholic pancreatitis: A systematic review and meta-analysis.
Genetic polymorphism in cytochrome P450 2E1 and alcoholic pancreatitis sus-ceptibility: a meta-analysis.
Role of alcohol metabolism in alcoholic pancreatitis.
Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis.
Pancreatitis, Chronic
'Not knowing something is normally a milestone on the way to knowledge'. An interview with Joan M. Braganza, DSc, FRCP, FRCPath, Reader Emeritus, University of Manchester, UK.
Abnormal drug metabolism in chronic pancreatitis. Treatment with antioxidants.
Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals.
Antioxidants, enzyme induction, and chronic pancreatitis: a reappraisal following studies in patients on anticonvulsants.
Differences in immunohistochemical expression of xenobiotic-metabolizing enzymes between normal pancreas, chronic pancreatitis and pancreatic cancer.
Involvement of free radicals in the pathophysiology of chronic pancreatitis: potential of treatment with antioxidant and scavenger substances.
Micronutrient antioxidant status in tropical compared with temperate-zone chronic pancreatitis.
Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.
Phenotypic CYP2A6 variation and the risk of pancreatic cancer.
Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics.
Selenium deficiency and chronic pancreatitis: disease mechanism and potential for therapy.
Toward an animal model of chronic pancreatitis. Pancreatobiliary secretion in hamsters on long-term treatment with chemical inducers of cytochromes P450.
Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis.
Xenobiotic metabolism, oxidant stress and chronic pancreatitis. Focus on glutathione.
[Polymorphism of ethanol metabolism genes in alcoholic chronic pancreatitis].
Pancytopenia
Colchicine: serious interactions.
Pantothenate Kinase-Associated Neurodegeneration
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Papilloma
Concomitance of oncogenic HPV types, CHEK2 gene mutations, and CYP1B1 gene polymorphism as an increased risk factor for malignancy.
Differential induction of Cyp1a1, Cyp1b1, Ahd4, and Nmo1 in murine skin tumors and adjacent normal epidermis by ligands of the aryl hydrocarbon receptor.
Effects of benzo[a]pyrene, aromatic amines, and a combination of both on CYP1A1 activities in RT-4 human bladder papilloma cells.
Papillomavirus Infections
CYP1B1 C4326G polymorphism and susceptibility to cervical cancer in Chinese Han women.
Functional variants in CYP1A1 and GSTM1 are associated with clearance of cervical HPV infection.
Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection.
Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India.
Paralysis
2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity.
A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism.
Anti-clastogenic effect of magnolol-containing Hange-koboku-to, Dai-joki-to, Goshaku-san, and Magnoliae Cortex on benzo(a)pyrene-induced clastogenicity in mice.
Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo.
Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism.
Effect of novel anti-inflammatory ethanolamine derivatives with antioxidant properties on drug metabolising enzymes.
In vivo modulation of the rat cytochrome P450 1A1 by double-stranded phosphorothioate oligodeoxynucleotides.
In-vivo effects of itraconazole on hepatic mixed-function oxidase.
Inhibitory effect of magnolol on Trp-P-2-induced DNA damage in various organs in mice.
Intensity of Schistosoma mansoni infection determines alterations in hepatic drug metabolism.
Moricizine, an antiarrhythmic agent, as a potent inhibitor of hepatic microsomal CYP1A.
Neonatal toxicity in mice associated with the Ahb allele following transplacental exposure to 3-methylcholanthrene.
The Ah regulatory gene product. Survey of nineteen polycyclic aromatic compounds' and fifteen benzo[a]pyrene metabolites' capacity to bind to the cytosolic receptor.
The murine aromatic hydrocarbon responsiveness locus: a comparison of receptor levels and several inducible enzyme activities among recombinant inbred lines.
Paraplegia
A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform.
An atypical case of SPG56/CYP2U1-related spastic paraplegia presenting with delayed myelination.
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review.
Plasma oxysterols: biomarkers for diagnosis and treatment in spastic paraplegia type 5.
Parasitemia
The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment.
Parasitic Diseases
A non-hepatotropic parasite infection increases mortality in the acetaminophen-induced acute liver failure murine model: possible roles for IL-5 and IL-6.
CYP2D6 variability in populations from Venezuela.
Incidence of experimental fascioliasis on the activity of drug-metabolizing enzymes in lamb liver.
Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini.
Parathyroid Neoplasms
A Possible Link Between Parathyroid Hormone Secretion and Local Regulation of GABA in Human Parathyroid Adenomas.
An Excess of CYP24A1, Lack of CaSR, and a Novel lncRNA Near the PTH Gene Characterize an Ectopic PTH-Producing Tumor.
Paresis
A synopsis on different homologous series of fomocaine derivatives. In vitro interactions with the cytochrome P450 system, toxicity, and local anaesthetic effects in rats--Part 1.
Cholestenoic acids regulate motor neuron survival via liver X receptors.
Parkinson Disease
ADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson's Disease.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: partial protection against striato-nigral dopamine depletion in C57BL/6J mice by cigarette smoke exposure and by beta-naphthoflavone-pretreatment.
A novel cytochrome P-450IID6 mutant gene associated with Parkinson's disease.
Absence of effect of seven functional mutations in the CYP2D6 gene in Parkinson's disease.
Acetaminophen metabolism by cytochrome P450 monooxygenases in Parkinson's disease.
An attempt to replicate interaction between coffee and CYP1A2 gene in connection to Parkinson's disease.
ApoE and CYP2D6 polymorphism with and without parkinsonism-dementia complex in the people of Chamorro, guam.
APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population.
Association between the oxidative polymorphism and early onset of Parkinson's disease.
Association of CYP2D microsatellite polymorphism with Lewy body variant of Alzheimer's disease.
Association of polymorphism in cytochrome P450 2D6 and N-acetyltransferase-2 with Parkinson's disease.
Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease.
Characterization and localization of cytochrome P450 mediated metabolism of MPTP to nor-MPTP in mouse brain: relevance to Parkinson's disease.
Co-localization of P450 enzymes in the rat substantia nigra with tyrosine hydroxylase.
Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson's disease.
CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes.
CYP2D6 allelic frequencies in young-onset Parkinson's disease.
CYP2D6 gene polymorphism as a probable risk factor for Alzheimer's disease and Parkinson's disease with dementia.
CYP2D6 HhaI genotype and the neuroleptic malignant syndrome.
CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease.
CYP2D6 phenotypes and Parkinson's disease risk: a meta-analysis.
CYP2D6 polymorphism and Parkinson's disease susceptibility.
CYP2D6 polymorphism in Parkinson's disease: the Rotterdam Study.
CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease.
CYP2D6*4 allele polymorphism increases the risk of Parkinson's disease: evidence from meta-analysis.
CYP2D6-debrisoquine hydroxylase gene polymorphism in multiple system atrophy.
Cytochrome P450 2D6 and Parkinson's Disease: Polymorphism, Metabolic Role, Risk and Protection.
Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells.
Cytochrome P450 2E1 gene polymorphisms/haplotypes and Parkinson's disease in a Swedish population.
Cytochrome P450 2E1 in the substantia nigra: Relevance for dopaminergic neurotransmission and free radical production.
Cytochrome P450 and Parkinson's disease. Poor parahydroxylation of phenytoin.
Cytochrome P450 and Parkinson's disease: protective role of neuronal CYP 2E1 from MPTP toxicity.
Cytochrome P450 CYP2D6.
Cytochrome P450 in neurological disease.
Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4-tetrahydroisoquinoline in rat liver microsomes.
Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.
Cytochrome P450-dependent metabolism of l-deprenyl in monkey (Cercopithecus aethiops) and C57BL/6 mouse brain microsomal preparations.
Debrisoquine 4-hydroxylase (CYP2D6) genetic polymorphisms and susceptibility to schizophrenia in Chinese patients from Taiwan.
Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease.
Debrisoquine hydroxylase gene polymorphism in familial Parkinson's disease.
Differential expression of cytochrome P450 enzymes in cultured and intact foetal rat ventral mesencephalon.
Effect of reboxetine on major depressive disorder in breast cancer patients: an open-label study.
Evaluating environmental impact of STP effluents on receiving water in Beijing by the joint use of chemical analysis and biomonitoring.
Expression and localisation of CYP2D enzymes in rat basal ganglia.
Familial Parkinson's disease and polymorphism at the CYP2D6 locus.
Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease.
Gene-environment interaction in parkinson's disease. The case of CYP2D6 gene polymorphism.
Gene-Environment Interaction in Parkinson's Disease: Coffee, ADORA2A, and CYP1A2.
Genetic analysis of the CYP2D6 gene in patients with Parkinson's disease.
Genetic and environmental risk factors for Parkinson's disease in a Chinese population.
Genetic polymorphism and Parkinson's disease in Taiwan: study of debrisoquine 4-hydroxylase (CYP2D6).
Genetic polymorphism of cytochrome P450 2D6 in idiopathic Parkinson disease and diffuse Lewy body disease.
Genetic polymorphism of the CYP2E1 gene and susceptibility to Parkinson's disease in Taiwanese.
Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands.
Genetic susceptibility and the occurrence of Parkinson's disease.
Genetic variability of the CYP 2D6 gene is not a risk factor for sporadic Parkinson's disease.
Genetics and Parkinson's disease.
Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1.
Genotyping of CYP2D6 in Parkinson's disease.
Hepatic cytochrome P450 malfunction and Parkinson's disease.
Human metastable epiallele candidates link to common disorders.
Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risk.
Interaction between GSTM1-null and CYP2D6-deficient alleles in the pathogenesis of Parkinson's disease.
Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.
Is there a genetic susceptibility locus for Parkinson's disease on chromosome 22q13?
l-Deprenyl metabolism by the cytochrome P450 system in monkey (Cercopithecus aethiops) liver microsomes.
Lack of association between CYP1A1 polymorphism and Parkinson's disease in a Chinese population.
Lack of association between cytochrome P450 2E1 gene polymorphisms and Parkinson's disease in a Chinese population.
Lack of relation between genetic polymorphism of cytochrome P-450IID6 and sporadic idiopathic Parkinson's disease.
Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's disease?
Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease.
Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.
Metabolism of glucurolactone to glucarate in Parkinson's disease.
MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation.
MPTP-induced model of Parkinson's disease in cytochrome P450 2E1knockout mice.
Mutant debrisoquine hydroxylation genes in Parkinson's disease.
Mutation frequencies of the cytochrome CYP2D6 gene in Parkinson disease patients and in families.
Neurogenetic correlates of Parkinson's disease: apolipoprotein-E and cytochrome P450 2D6 genetic polymorphism.
No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population.
Oxidative mechanisms in nigral cell death in Parkinson's disease.
P450 and heme oxygenase enzymes in the basal ganglia and their roles in Parkinson's disease.
P450 enzymes and Parkinson's disease.
P450 enzymes and Parkinson's disease: the story so far.
Parkinson's disease and CYP1A2 activity.
Parkinson's disease and CYP2D6 polymorphism in Asian populations: A meta-analysis.
Parkinson's disease and cytochrome P450: a possible link?
Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene.
Parkinson's disease, CYP2D6 polymorphism, and age.
Phenytoin parahydroxylation is not impaired in patients with young-onset Parkinson's disease.
pNAT and CYP2D6 gene polymorphism in epileptic patients.
Polymorphic cytochromes P450 and drugs used in psychiatry.
Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease.
Proteomics analyses for the global proteins in the brain tissues of different human prion diseases.
Rarity of debrisoquine hydroxylase gene polymorphism in Chinese patients with Parkinson's disease.
Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid.
Response to Hill-Burns et al. letter: An attempt to replicate interaction between coffee and CYP1A2 gene in connection to Parkinson's disease.
Resveratrol potentiates cytochrome P450 2d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse.
Selective localisation of P450 enzymes and NADPH-P450 oxidoreductase in rat basal ganglia using anti-peptide antisera.
SSRI-induced extrapyramidal side-effects and akathisia: implications for treatment.
The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis.
The CYP2D6B allele is not overrepresented in a population of German patients with idiopathic Parkinson's disease.
The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.
The HhaI polymorphism in the CYP2D6 gene is not associated with Parkinson's disease in a Caucasian population.
The neuroprotective effects of caffeine in neurodegenerative diseases.
The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients.
Tryptamine: a possible endogenous substrate for CYP2D6.
Unveiling the Role of Cytochrome P450 (2E1) in Human Brain Specifically in Parkinson's Disease - Literature Review.
Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease.
[Genetic and environmental factors of Parkinson's disease]
[Genetic polymorphisms of cytochrome P450 1A1 and susceptibility of early-onset Parkinson's disease]
[Genetics and environmental factors of Parkinson disease]
[Polymorphisms in the genes of cytochrome oxidase P450 2D6 (CYP2D6), paraoxonase 1 (PON1) and apolipoprotein E (APOE) as risk factors for Parkinson's disease]
[Prevalence of CYPD6 mutations in sporadic Parkinson's disease: case-control study]
[Role of gene polymorphism of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAOB), cytochrome P450 2D6 (CYP2D6) and N-acetyltransferase 2 (NAT2) in pathogenesis of Parkinson's disease]
Parkinsonian Disorders
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a substrate of cytochrome P450 2D6: allosteric effects of NADPH-cytochrome P450 reductase.
Acetaldehyde and parkinsonism: role of CYP450 2E1.
Acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in a model of rat designated a poor metabolizer of debrisoquine.
Association of tardive dyskinesia with variation in CYP2D6: Is there a role for active metabolites?
Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
CYP2D6 polymorphism is not associated with essential tremor.
Cytochrome P450 2D6 and Parkinson's Disease: Polymorphism, Metabolic Role, Risk and Protection.
Cytochrome p450 and parkinsonism: protective role of CYP2E1.
Cytochrome p450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing?
Cytochrome P450 polymorphisms and response to antipsychotic therapy.
Involvement of Peroxiredoxin-3, Thioredoxin-2, and Protein Deglycase-1 in Cypermethrin-Induced Parkinsonism.
Maintenance therapy with zuclopenthixol decanoate: associations between plasma concentrations, neurological side effects and CYP2D6 genotype.
Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease.
Mitochondrial NADH dehydrogenase and CYP2D6 genotypes in Lewy-body parkinsonism.
Oxidative mechanisms in nigral cell death in Parkinson's disease.
Parkinson's disease and CYP1A2 activity.
Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.
Resveratrol potentiates cytochrome P450 2d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse.
Resveratrol regulates Nrf2-mediated expression of antioxidant and xenobiotic metabolizing enzymes in pesticides-induced Parkinsonism.
Sex differences in autophagy-mediated diseases: toward precision medicine.
The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation.
The CYP2D6B allele is not overrepresented in a population of German patients with idiopathic Parkinson's disease.
Pediatric Obesity
Potential role of aryl hydrocarbon receptor signaling in childhood obesity.
The impacts of the interaction of genetic variation, CYP11?2 and NEDD4L, with sodium intake on pediatric obesity with gender difference: a 3-year panel study.
Pemphigoid, Bullous
The impact of the CYP2D6 gene polymorphism on the risk of pemphigoid.
Peptic Ulcer
Allele variants of the cytochrome P450 2C9 genotype in white subjects from The Netherlands with serious gastroduodenal ulcers attributable to the use of NSAIDs.
CYP3A and CYP2C19 activity in urine in relation to CYP3A4, CYP3A5, and CYP2C19 polymorphisms in Russian peptic ulcer patients taking omeprazole.
Effects of Genetic Polymorphisms of Cytochrome P450 Enzymes and MDR1 Transporter on Pantoprazole Metabolism and Helicobacter pylori Eradication.
Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection.
Impact of body size on first-line Helicobacter pylori eradication success using vonoprazan and amoxicillin dual therapy.
The frequency of CYP2C19 genetic polymorphisms in Russian patients with peptic ulcers treated with proton pump inhibitors.
Pericardial Effusion
A Possible Drug-Drug Interaction Between Eliquis and Amiodarone Resulting in Hemopericardium.
Fluoranthene, but not benzo[a]pyrene, interacts with hypoxia resulting in pericardial effusion and lordosis in developing zebrafish.
Periodontitis
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
Polymorphisms in genes coding for enzymes metabolizing smoking-derived substances and the risk of periodontitis.
Protective roles of FICZ and aryl hydrocarbon receptor axis on alveolar bone loss and inflammation in experimental periodontitis.
Peripheral Arterial Disease
Acetylation phenotype and cytochrome P450IA2 phenotype are unlikely to be associated with peripheral arterial disease.
Patients carrying CYP2C19 loss of function alleles have a reduced response to clopidogrel therapy and a greater risk of in-stent restenosis after endovascular treatment of lower extremity peripheral arterial disease.
Peripheral Nerve Injuries
[The role of CYP2E1 in the protection of garlic oil's from n-hexane-induced neurotoxicity].
Peripheral Nervous System Diseases
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review.
Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status.
Differential interactions of Cytochrome P450 3A5 and 3A4 with chemotherapeutic agent- vincristine: A comparative molecular dynamics study.
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Drug interaction between itraconazole and bortezomib: exacerbation of peripheral neuropathy and thrombocytopenia induced by bortezomib.
Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients.
Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study.
Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia.
Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.
Severe Neuropathic Pain With Concomitant Administration of Vincristine and Posaconazole.
Severe Vincristine-induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study.
[Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs].
Peritonitis
Corrigendum to "Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6" [Cell. Immunol. 349 (2020) 104047].
CYP450-derived oxylipins mediate inflammatory resolution.
Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6.
Hepatic oxygen consumption and cytochrome P450 activity in experimental faecal peritonitis.
Mixed-function oxidase activity in sepsis.
Pharyngeal Neoplasms
CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control Study.
Cytochrome p450 metabolism of betel quid-derived compounds: implications for the development of prevention strategies for oral and pharyngeal cancers.
Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to head-and-neck squamous-cell carcinoma.
Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review.
The association of the CYP1A1 Ile462Val polymorphism with head and neck cancer risk: evidence based on a cumulative meta-analysis.
Pheochromocytoma
Overexpression of CYP2D6 attenuates the toxicity of MPP+ in actively dividing and differentiated PC12 cells.
Pheochromocytoma and sub-clinical Cushing's syndrome during pregnancy: diagnosis, medical pre-treatment and cure by laparoscopic unilateral adrenalectomy.
Phimosis
Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter.
phospholipase a2 deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Photophobia
Phototoxicity of plant secondary metabolites: insect and mammalian perspectives.
Photosensitivity Disorders
Inhibition of 6-formylindolo[3,2-b]carbazole metabolism sensitizes keratinocytes to UVA-induced apoptosis: Implications for vemurafenib-induced phototoxicity.
Photosensitizing Furocoumarins: Content in Plant Matrices and Kinetics of Supercritical Carbon Dioxide Extraction.
Studies on the nature of in vitro and in vivo photosensitization reactions by psoralens and porphyrins.
Pituitary Neoplasms
Aromatase P450 expression in human pituitary adenomas.
CYP2D6 genetic polymorphisms are associated with susceptibility to pituitary tumors.
Glutathione S-Transferases and Cytochrome P450 Enzyme Expression in Patients with Intracranial Tumors: Preliminary Report of 55 Patients.
GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp.
Multiple structural and functional abnormalities in the p450 aromatase expressing transgenic male mice are ameliorated by a p450 aromatase inhibitor.
Pleural Effusion
Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole.
Pleurisy
CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications.
Pneumoconiosis
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Pneumonia
A comparison of available and investigational antibiotics for complicated skin infections and treatment-resistant Staphylococcus aureus and enterococcus.
Association of the ACE, GSTM1, IL-6, NOS3, and CYP1A1 polymorphisms with susceptibility of mycoplasma pneumoniae pneumonia in Chinese children.
Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles.
CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications.
Cytochrome P450 metabolites of arachidonic acid but not cyclooxygenase-2 metabolites contribute to the pulmonary vascular hyporeactivity in rats with acute Pseudomonas pneumonia.
Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice.
Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children.
Pulmonary cytochrome P-450 2J4 is reduced in a rat model of acute Pseudomonas pneumonia.
Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene.
Regulation of pulmonary and hepatic cytochrome P4501A expression in the rat by hyperoxia: implications for hyperoxic lung injury.
Role of mouse cytochrome P450 enzymes of the CYP2ABFGS subfamilies in the induction of lung inflammation by cigarette smoke exposure.
[Aryl hydrocarbon receptor modulates airway inflammation in mice with cockroach allergen-induced asthma by regulating Th17/Treg differentiation].
[Genetic study of predisposition to community-acquired pneumonia].
Polycystic Kidney Diseases
Distinct oxylipin alterations in diverse models of cystic kidney diseases.
Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology.
Enhancing effects of 2-amino-4,5-diphenylthiazole-induced polycystic kidneys on renal carcinogenesis in rats treated with dimethylnitrosamine.
Polycystic Kidney, Autosomal Dominant
Association of Vitamin D Levels With Kidney Volume in Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Polycystic Kidney, Autosomal Recessive
Distinct oxylipin alterations in diverse models of cystic kidney diseases.
Polycystic Ovary Syndrome
A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese.
Acupuncture does not ameliorate metabolic disturbances in the P450 aromatase inhibitor-induced rat model of polycystic ovary syndrome.
Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome.
Association between CYP19 gene SNP rs2414096 polymorphism and polycystic ovary syndrome in Chinese women.
Association of CYP17A1 gene -34T/C polymorphism with polycystic ovary syndrome in Han Chinese population.
Association of the CYP17 and CYP19 gene polymorphisms in women with polycystic ovary syndrome from Punjab, Pakistan.
Association Study of CYP17 and HSD11B1 in Polycystic Ovary Syndrome Utilizing Comprehensive Gene Coverage.
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Common genetic variation in CYP1B1 is associated with concentrations of T4, FT 3 and FT 4 in the sera of polycystic ovary syndrome patients.
Common polymorphisms in the CYP1A1 and CYP11A1 genes and polycystic ovary syndrome risk: a meta-analysis and meta-regression.
Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age.
CYP19 gene expression in subcutaneous adipose tissue is associated with blood pressure in women with polycystic ovary syndrome.
CYP19 gene rs2414096 variant and differential genetic risk of polycystic ovary syndrome: a systematic review and meta-analysis.
CYP19 gene variants affect the assisted reproduction outcome of women with polycystic ovary syndrome.
CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotype.
CYP1A1 gene (6235T
CYP1A1 gene polymorphism and polycystic ovary syndrome.
CYP1A1 Gene Polymorphisms and Polycystic Ovary Syndrome Risk: A Meta-Analysis and Meta-Regression.
CYP1A1 polymorphism in adolescents with polycystic ovary syndrome.
Effects of testosterone on PPAR? and P450arom expression in polycystic ovary syndrome patients and related mechanisms.
Evaluation of the association between the CYP19 Tetranucleotide (TTTA)n polymorphism and polycystic ovarian syndrome(PCOS) in Han Chinese women.
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis.
Functional investigation on aromatase in endometrial hyperplasia in polycystic ovary syndrome cases.
Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome.
Granulosa cell aromatase enzyme activity: effects of follicular fluid from patients with polycystic ovary syndrome, using aromatase conversion and [11C]vorozole-binding assays.
Impact of rs2414096 polymorphism of CYP19 gene on susceptibility of polycystic ovary syndrome and hyperandrogenism in Kashmiri women.
Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome.
Lack of an association between CYP1A1 gene Ile462Val polymorphism and polycystic ovary syndrome in Chinese.
Modulation of steroidogenesis by vitamin D3 in granulosa cells of the mouse model of polycystic ovarian syndrome.
No evidence of mutations in the P450 aromatase gene in patients with polycystic ovary syndrome.
Placental steroidogenesis in pregnant women with polycystic ovary syndrome.
Role of A-kinase anchoring protein 95 in the regulation of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) in human ovarian granulosa cells.
Role of epigenetic modifications in the aberrant CYP19A1 gene expression in polycystic ovary syndrome.
SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients.
The (TTTA)n polymorphism in intron 4 of CYP19 and the polycystic ovary syndrome risk in a Chinese population.
The relationship between the CYP19 alleles rs727479A/C, rs700518A/G, and rs700519C/T and pregnancy outcome after assisted reproductive technology in patients with polycystic ovary syndrome in a Chinese population: A population-based study.
The single-nucleotide polymorphism rs743572 of CYP17A1 shows significant association with polycystic ovary syndrome: a meta-analysis.
Transcutaneous electrical acupoint stimulation alleviates the hyperandrogenism of polycystic ovarian syndrome rats by regulating the expression of P450arom and CTGF in the ovaries.
Typical hormonal profiles are accompanied by increased immunoreactivity of theca folliculi steroid 17 alpha-hydroxylase P450 in polycystic ovary syndrome.
[Polymorphism of CYP11A1 gene in Chinese patients with polycystic ovarian syndrome]
Polycythemia
CYP17A1 and CYP2E1 variants associated with high altitude polycythemia in Tibetans at the Qinghai-Tibetan Plateau.
Polycythemia Vera
CYP1AI, glutathione S-transferase gene polymorphisms and risk of Polycythemia vera.
Polyendocrinopathies, Autoimmune
Autoimmunity to steroid-producing cells and familial polyendocrine autoimmunity.
Novel AIRE mutations and P450 cytochrome autoantibodies in Central and Eastern European patients with APECED.
Porphyria Cutanea Tarda
Association between CYP1A2 polymorphism and susceptibility to porphyria cutanea tarda.
Comprehensive cytochrome P450 CYP1A2 gene analysis in French caucasian patients with familial and sporadic porphyria cutanea tarda.
Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of porphyria cutanea tarda.
Hepatic arachidonic acid metabolism is disrupted after hexachlorobenzene treatment.
No significant association between CYP1A2 polymorphism and porphyria cutanea tarda.
Smoking but not homozygosity for CYP1A2 g-163A allelic variant leads to earlier disease onset in patients with sporadic porphyria cutanea tarda.
Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron.
Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.
Porphyria, Acute Intermittent
High penetrance of acute intermittent porphyria in a Spanish founder mutation population and CYP2D6 genotype as a susceptibility factor.
Porphyrias
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies.
Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinate.
Association between CYP1A2 polymorphism and susceptibility to porphyria cutanea tarda.
Comparative toxicity of polychlorinated biphenyls to Japanese quail (Coturnix c. japonica) and American kestrels (Falco sparverius).
Comprehensive cytochrome P450 CYP1A2 gene analysis in French caucasian patients with familial and sporadic porphyria cutanea tarda.
CYP2D6 polymorphisms in patients with porphyrias.
Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of porphyria cutanea tarda.
Development of porphyria cutanea tarda after treatment with cyclophosphamide.
Effects of heme arginate on cytochrome P450-mediated metabolism of drugs in patients with variegate porphyria and in healthy men.
Formation of N-alkylprotoporphyrin IX after interaction of porphyrinogenic xenobiotics with rat liver microsomes.
Formation of N-methyl protoporphyrin in chemically-induced protoporphyria. Studies with a novel porphyrogenic agent.
Hepatic arachidonic acid metabolism is disrupted after hexachlorobenzene treatment.
High penetrance of acute intermittent porphyria in a Spanish founder mutation population and CYP2D6 genotype as a susceptibility factor.
Identification of human hepatic cytochrome P450 sources of N-alkylprotoporphyrin IX after interaction with porphyrinogenic xenobiotics, implications for detection of xenobiotic-induced porphyria in humans.
Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism.
Microsomal enzyme induction and clinical aggravation of porphyria: the evaluation of human urinary 6beta-hydroxycortisol/cortisol ratio as the index of hepatic CYP3A4 activity.
Modulation by iron of hepatic microsomal and nuclear cytochrome P450, and cytosolic glutathione S-transferase and peroxidase in C57BL/10ScSn mice induced with polychlorinated biphenyls (Aroclor 1254).
Mutation frequency in the lacI gene of liver DNA from lambda/lacI transgenic mice following the interaction of PCBs with iron causing hepatic cancer and porphyria.
No significant association between CYP1A2 polymorphism and porphyria cutanea tarda.
Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria.
Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice.
Smoking but not homozygosity for CYP1A2 g-163A allelic variant leads to earlier disease onset in patients with sporadic porphyria cutanea tarda.
The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice.
Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron.
Uroporphyrin accumulation associated with cytochrome P4501A induction in fish hepatoma cells exposed to aryl hydrocarbon receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and planar chlorobiphenyls.
Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.
Porphyrias, Hepatic
Cytochrome p450A1 polymorphisms in a Caucasian population with porphyria cutanea tarda.
Effect of haem arginate therapy on porphyrin metabolism and mixed function oxygenase activity in acute hepatic porphyria.
Effects of repeated administration with CP-55,940, a cannabinoid CB1 receptor agonist on the metabolism of the hepatic heme.
Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone.
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo. Evidence that hexachlorobenzene is a weak Ah receptor agonist.
Selective inhibitors of cytochromes P450.
Postpartum Hemorrhage
Anticonvulsants and the risk of perinatal bleeding complications: A pregnancy cohort study.
Prader-Willi Syndrome
Pharmacogenetic Testing of Cytochrome P450 Drug Metabolizing Enzymes in a Case Series of Patients with Prader-Willi Syndrome.
Pre-Eclampsia
8C.05: EPOXYEICOSATRIENOIC ACIDS ARE INCREASED IN PLACENTAS OF PREECLAMPTIC PREGNANCIES.
Arachidonic acid metabolites of CYP4A and CYP4F are altered in women with preeclampsia.
Associations of polymorphisms of CYP2D6 and CYP2C9 with early onset severe pre-eclampsia and response to labetalol therapy.
Cytochrome P450 metabolites of arachidonic acid in the control of renal function.
Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia.
Cytochrome P450-mediated metabolic alterations in preeclampsia evaluated by quantitative steroid signatures.
Diverse mechanisms of endothelium-derived hyperpolarizing factor-mediated dilatation in small myometrial arteries in normal human pregnancy and preeclampsia.
Early onset pre-eclampsia is associated with altered DNA methylation of cortisol-signalling and steroidogenic genes in the placenta.
Increased epoxyeicosatrienoic acids and reduced soluble epoxide hydrolase expression in the preeclamptic placenta.
Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia.
Maternal and fetal epoxyeicosatrienoic acids in normotensive and preeclamptic pregnancies.
Maternal vitamin D status in preeclampsia: seasonal changes are not influenced by placental gene expression of vitamin D metabolizing enzymes.
OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia.
Oxidative stress-related gene polymorphism and the risk of preeclampsia.
Second-Trimester Maternal Serum Paraxanthine, CYP1A2 Activity, and the Risk of Severe Preeclampsia.
Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes.
Precancerous Conditions
[Smoking and induction of the enzyme aryl hydrocarbon hydroxylase in patients with laryngeal carcinomas and precancerous conditions]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome.
CYP3A5 FNx01 3 genetic polymorphism is associated with childhood acute lymphoblastic leukemia risk: A meta-analysis.
Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients.
Differential interactions of Cytochrome P450 3A5 and 3A4 with chemotherapeutic agent- vincristine: A comparative molecular dynamics study.
DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia.
Does cytochrome P450 1A1 MspI polymorphism increase acute lymphoblastic leukemia risk? Evidence from 2013 cases and 2903 controls.
Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia.
Gene variants of CYP1A1 and CYP2D6 and the risk of childhood acute lymphoblastic leukaemia; outcome of a case control study from Kashmir, India.
Genetic polymorphism of CYP1A1, CYP2D6, GSTM1 and GSTT1 and susceptibility to acute lymphoblastic leukaemia in Indian children.
Genetic polymorphisms and vincristine-induced peripheral neuropathy in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy.
Genetic polymorphisms of CYP1A1 and risk of leukemia: a meta-analysis.
Genetic polymorphisms of CYP1A1, CYP2D6, GSTM1, and GSTT1 and susceptibility to acute lymphoblastic leukemia in Indian children.
Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility.
Genetic polymorphisms of NQO1, CYP1A1 and TPMT and susceptibility to acute lymphoblastic leukemia in a Tunisian population.
Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia.
Impact of aberrant DNA methylation patterns including CYP1B1 methylation in adolescents and young adults with acute lymphocytic leukemia.
Impact of CYP1A1, GSTP1 and XRCC1 genes polymorphisms on toxicity and response to chemotherapy in childhood acute lymphoblastic leukemia.
Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia.
Low constitutive activity of aryl hydrocarbon hydroxylase in phytohaemoagglutinin-stimulated peripheral blood mononuclear cells of children after treatment for acute lymphoblastic leukemia.
Pedigree analysis of aryl hydrocarbon hydroxylase inducibility in acute leukemia of childhood.
Polymorphism of CYP1A1 gene and susceptibility to childhood acute lymphoblastic leukemia in Egypt.
Polymorphisms in CYP1A1 and ethnic-specific susceptibility to acute lymphoblastic leukemia in children.
Polymorphisms in genes involved in vincristine pharmacokinetics or pharmacodynamics are not related to impaired motor performance in children with leukemia.
Role of CXCL12, TP53 and CYP1A1 gene polymorphisms in susceptibility to pediatric acute lymphoblastic leukemia.
Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.
Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children.
Significance of genetic polymorphisms at multiple loci of CYP2E1 in the risk of development of childhood acute lymphoblastic leukemia.
Susceptibility to childhood acute lymphoblastic leukemia: influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 genetic polymorphisms.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility.
The impact of CYP3A5*3 on risk and prognosis in childhood acute lymphoblastic leukemia.
Pregnancy Complications
Adverse birth outcomes associated with maternal smoking and polymorphisms in the N-Nitrosamine-metabolizing enzyme genes NQO1 and CYP2E1.
Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes.
The Function of Cytochrome P450 1A1 Enzyme (CYP1A1) and Aryl Hydrocarbon Receptor (AhR) in the Placenta.
Pregnancy, Tubal
Expression of P450 aromatase and 17beta-hydroxysteroid dehydrogenase type 1 at fetal-maternal interface during tubal pregnancy.
Premature Birth
Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers.
The association among cytochrome P450 3A, progesterone receptor polymorphisms, plasma 17-alpha hydroxyprogesterone caproate concentrations, and spontaneous preterm birth.
The Function of Cytochrome P450 1A1 Enzyme (CYP1A1) and Aryl Hydrocarbon Receptor (AhR) in the Placenta.
[Research progress of the gene polymorphisms of metabolic enzyme related to polycyclic aromatic hydrocarbons risk of preterm birth].
Premature Ejaculation
Effects of Grapefruit and Pomegranate Juices on the Pharmacokinetic Properties of Dapoxetine and Midazolam in Healthy Subjects.
Presbycusis
Association of oxidative stress gene polymorphisms with presbycusis.
CYP1A1 and GSTs common gene variations and presbycusis risk: a genetic association analysis and a bioinformatics approach.
Primary Myelofibrosis
Ruxolitinib exposure in patients with acute and chronic graft versus host disease in routine clinical practice-a prospective single-center trial.
Primary Ovarian Insufficiency
Adrenal-cortex autoantibodies and steroid-producing cells autoantibodies in patients with Addison's disease: comparison of immunofluorescence and immunoprecipitation assays.
Cytochrome P450 family proteins as potential biomarkers for ovarian granulosa cell damage in mice with premature ovarian failure.
Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis.
Cytochrome P450 Polymorphisms and their Relationship with Premature Ovarian Failure in Premenopausal Women with Breast Cancer Receiving Doxorubicin and Cyclophosphamide.
Premature Ovarian Failure in Patients with Autoimmune Addison's Disease: Clinical, Genetic, and Immunological Evaluation.
Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity.
The significance of polymorphism and expression of oestrogen metabolism-related genes in Chinese women with premature ovarian insufficiency.
Proctitis
Expression of cytochrome P450 and MDR1 in patients with proctitis.
Prolactinoma
Aromatase cytochrome P450 enzyme expression in prolactinomas and its relationship to tumor behavior.
Expression of aromatase P450 is increased in spontaneous prolactinomas of aged rats.
Increased expression of aromatase cytochrome P450 enzyme is associated with prolactinoma invasiveness in post-menopausal women.
Relation among Aromatase P450 and Tumoral Growth in Human Prolactinomas.
Prostatic Hyperplasia
Aryl hydrocarbon hydroxylase in human prostate.
Association of Androgen Receptor, Prostate-Specific Antigen, and CYP19 Gene Polymorphisms with Prostate Carcinoma and Benign Prostatic Hyperplasia in a North Indian Population.
Association of CYP1A1, CYP1B1 and CYP17 gene polymorphisms and organochlorine pesticides with benign prostatic hyperplasia.
Associations of SRD5A2/CYP17/CYP19/VDR gene polymorphisms with the development and clinical progression of benign prostatic hyperplasia: a case-control study in northern Chinese population.
Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer.
Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer.
Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer.
Genetic polymorphism in sex hormone metabolism and prostate cancer risk.
Joint effects of inflammation and androgen metabolism on prostate cancer severity.
Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue.
TGF-?1 signaling plays a dominant role in the crosstalk between TGF-?1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells.
The androgen receptor CAG repeat length polymorphism associates with prostate volume in Finnish men with benign prostatic hyperplasia.
Prostatic Intraepithelial Neoplasia
Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue.
Prostatic Neoplasms
27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells.
?-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship.
A bypass mechanism of abiraterone-resistant prostate cancer: Accumulating CYP17A1 substrates activate androgen receptor signaling.
A multicentre analysis of abiraterone acetate in Canadian patients with metastatic castration-resistant prostate cancer.
A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer.
Abiraterone Acetate Induces CREB1 Phosphorylation and Enhances the Function of the CBP-p300 Complex, Leading to Resistance in Prostate Cancer Cells.
Abiraterone acetate to treat metastatic castration-resistant prostate cancer in combination with prednisone.
All-trans-retinoic acid modulation of drug-metabolizing enzyme activities: investigation with selective metabolic drug probes.
Altered expression of cytochrome P450 enzymes involved in metabolism of androgens and vitamin D in the prostate as a risk factor for prostate cancer.
An LC-MS/MS method for quantification of abiraterone, its active metabolites D(4)-abiraterone (D4A) and 5?-abiraterone, and their inactive glucuronide derivatives.
Analysis of polymorphic patterns in candidate genes in Israeli patients with prostate cancer.
Androgen metabolism genes in prostate cancer health disparities.
Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer.
Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12.
Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.
Association between CYP2E1 polymorphisms and susceptibility to prostate cancer.
Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan.
Association between the CYP3A4 and CYP3A5 polymorphisms and cancer risk: a meta-analysis and meta-regression.
Association of androgen metabolism gene polymorphisms with prostate cancer risk and androgen concentrations: Results from the Prostate Cancer Prevention Trial.
Association of CYP1A1 polymorphisms with prostate cancer risk: an updated meta-analysis.
Association of CYP1A1 rs1048943 Polymorphism with Prostate Cancer in Iraqi Men Patients.
Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer.
Association of the CYP1B1 Leu432Val polymorphism with the risk of prostate cancer: a meta-analysis.
Association of the CYP24A1-rs2296241 polymorphism of the vitamin D catabolism enzyme with hormone-related cancer risk: a meta-analysis.
Association of the genetic polymorphism in cytochrome P450 (CYP) 1A1 with risk of familial prostate cancer in a Japanese population: a case-control study.
Association of the genetic polymorphism of the CYP19 intron 4[TTTA]n repeat with familial prostate cancer risk in a Japanese population.
Association of variants in estrogen-related pathway genes with prostate cancer risk.
Association study of cytochrome P450 1A1*2A polymorphism with prostate cancer risk and aggressiveness in Croatians.
Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race.
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.
Biochanin A induction of sulfotransferases in rats.
Biphenyl urea derivatives as selective CYP1B1 inhibitors.
Characterization of androgen-regulated expression of CYP3A5 in human prostate.
Combination of polymorphisms from genes related to estrogen metabolism and risk of prostate cancers: the hidden face of estrogens.
Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer.
Constitutive and inducible expression of cytochromes P4501A (CYP1A1 and CYP1A2) in normal prostate and prostate cancer cells.
Correction to: Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan.
Correction: Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation.
Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow.
CYP 1A1 polymorphism and organochlorine pesticides levels in the etiology of prostate cancer.
CYP17 polymorphisms and prostate cancer outcomes.
CYP17, SRD5A2, CYP1B1, and CYP2D6 gene polymorphisms with prostate cancer risk in North Indian population.
CYP19 TCT tri-nucleotide Del/Del genotype is a susceptibility marker for prostate cancer in a Taiwanese population.
CYP1A1 and GSTM1 polymorphic genotypes in patients with prostate cancer in a Turkish population.
CYP1A1 MspI polymorphism is associated with prostate cancer susceptibility: evidence from a meta-analysis.
CYP1A1 polymorphisms and risk of prostate cancer: a meta-analysis.
CYP1B1 polymorphisms and susceptibility to prostate cancer: a meta-analysis.
CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKC? activation and phosphorylation of XIAP.
CYP1B1 variants are associated with prostate cancer in non-Hispanic and Hispanic Caucasians.
CYP24A1 rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System.
CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer.
CYP3A4 and CYP3A5 genotypes, haplotypes, and risk of prostate cancer.
CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer.
CYP3A5 gene polymorphism and risk of prostate cancer in a Japanese population.
CYP3A5 regulates prostate cancer cell growth by facilitating nuclear translocation of AR.
Cytochrome P1B1 (CYP1B1) polymorphisms and cancer risk: a meta-analysis of 52 studies.
Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation.
Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer.
Cytochrome P450 2B6 is a growth-inhibitory and prognostic factor for prostate cancer.
Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer.
Cytochrome P4501A1 and glutathione S-transferase M1 genotypes as risk factors for prostate cancer in Japan.
Cytochrome P4501A1 and microsomal epoxide hydrolase gene polymorphisms: gene-environment interaction and risk of prostate cancer.
Cytochrome p4501A1 gene variants as susceptibility marker for prostate cancer.
Design and synthesis of ?-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation.
Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17?-hydroxylase-C17,20-lyase (Cyp17).
Dietary lipids and environmental xenobiotics as risk factors for prostate cancer: The role of cytochrome P450.
Durable Complete Response to Frontline Docetaxel in an Advanced Prostate Cancer Patient with Favourable CYP1B1 Isoforms: Suggestion for Changing Paradigms?
Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells.
Enzymatic and Nonenzymatic Electrochemical Interaction of Abiraterone (Antiprostate Cancer Drug) with Multiwalled Carbon Nanotube Bioelectrodes.
Epigenetic inactivation of the dioxin-responsive cytochrome P4501A1 gene in human prostate cancer.
Epigenetic regulation of the 1,25-dihydroxyvitamin D(3) 24-hydroxylase (CYP24A1) in colon cancer cells.
Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer.
Evaluation of 19-nor-2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxyvitamin D3 as a therapeutic agent for androgen-dependent prostate cancer.
Expression in human prostate of drug- and carcinogen-metabolizing enzymes: association with prostate cancer risk.
Expression of cytochrome P450 3A4 and its clinical significance in human prostate cancer.
Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells.
Formation of a novel topotecan metabolite in the hormone-independent human prostate carcinoma cell lines DU-145 and PC-3.
Frequency of CYP1B1 homozygous genotype 355T/T in prostate cancer families from Poland.
Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer.
Genetic polymorphism in sex hormone metabolism and prostate cancer risk.
Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population.
Genetic polymorphisms in the cytochrome P450 1A1 and 2E1 genes, smoking, drinking and prostate cancer susceptibility: a case-control study in a Han nationality population in Southern China.
Genetic polymorphisms of hormone-related genes and prostate cancer risk in the Japanese population.
Genetic susceptibility of CYP1A1 gene and risk of pesticide exposure in prostate cancer.
Genetic variants in the CYP24A1 gene are associated with prostate cancer risk and aggressiveness in a Korean study population.
Genetic variants of the CYP1B1 gene as predictors of biochemical recurrence after radical prostatectomy in localized prostate cancer patients.
Genetic Variation in the Vitamin D Pathway in Relation to Risk of Prostate Cancer - Results from the Breast and Prostate Cancer Cohort Consortium (BPC3).
Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-alpha-reductase type 2 is important for prostate cancer development.
High prevalence of potential drug-drug interactions in patients with castration-resistant prostate cancer treated with abiraterone acetate.
Hormone receptor-related gene polymorphisms and prostate cancer risk in North Indian population.
Human CYP1B1 Leu432Val gene polymorphism: ethnic distribution in African-Americans, Caucasians and Chinese; oestradiol hydroxylase activity; and distribution in prostate cancer cases and controls.
Impact of CYP1A1, GSTM1, and GSTT1 polymorphisms in overall and specific prostate cancer survival.
Impact of IGF-I and CYP19 gene polymorphisms on the survival of patients with metastatic prostate cancer.
In Vitro and In Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity.
Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D3-based therapies.
Influence of lifestyle choices on risks of CYP1B1 polymorphisms for prostate cancer.
Inhibition of aromatase (P450Arom) by some 1-(benzofuran-2-ylmethyl)imidazoles.
Inhibition of Protein Kinase CK2 Reduces Cyp24a1 Expression and Enhances 1,25-Dihydroxyvitamin D3 Antitumor Activity in Human Prostate Cancer Cells.
Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity.
Intratumoral Sterol-27-Hydroxylase (CYP27A1) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer.
Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study.
Joint effects of inflammation and androgen metabolism on prostate cancer severity.
Lack of Association of CYP1A1 Polymorphism with Prostate Cancer Susceptibility of Tunisian Men.
Lack of association of GSTT1, GSTM1, GSTO1, GSTP1 and CYP1A1 polymorphisms for susceptibility and outcome in Brazilian prostate cancer patients.
Limited expression of cytochrome p450 17?-hydroxylase/17,20-lyase in prostate cancer cell lines.
Mechanistic study on liver tumor promoting effects of flutamide in rats.
Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy.
No association between a tetranucleotide repeat polymorphism of CYP19 and prostate cancer.
P450 inhibitors of use in medical treatment: focus on mechanisms of action.
Paralogues of porcine aromatase cytochrome P450: a novel hydroxylase activity is associated with the survival of a duplicated gene.
Pharmacokinetic Drug-Drug Interaction of Apalutamide, Part 1: Clinical Studies in Healthy Men and Patients with Castration-Resistant Prostate Cancer.
Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk.
Polymorphism of cytochrome P450 2B6 and prostate cancer risk: a significant association in a Japanese population.
Polymorphisms in androgen metabolism genes AR, CYP1B1, CYP19, and SRD5A2and prostate cancer risk and aggressiveness in Bulgarian patients.
Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer risk.
Polymorphisms in estrogen related genes may modify the protective effect of isoflavones against prostate cancer risk in Japanese men.
Polymorphisms in NAT2, CYP2D6, CYP2C19 and GSTP1 and their association with prostate cancer.
Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk.
Polymorphisms in the CYP1B1 gene are associated with increased risk of prostate cancer.
Polymorphisms of CYP1A1, GSTM1, GSTT1, and Prostate Cancer Risk in Turkish Population.
Polymorphisms of Estrogen Metabolism-Related Genes and Prostate Cancer Risk in Two Populations of African Ancestry.
Polymorphisms of GSTM1 and CYP1A1 genes and their genetic susceptibility to prostate cancer in Chinese men.
Polymorphisms of the CYP1B1 gene have higher risk for prostate cancer.
Positive correlation between single or combined genotypes of CYP1A1 and GSTM1 in relation to prostate cancer in Chilean people.
Prevalent mutations in prostate cancer.
Prostate cancer risk and aggressiveness associated with the CYP1B1 4326C/G (Leu432Val) polymorphism: a meta-analysis of 2788 cases and 2968 controls.
Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462Val polymorphism and prostate cancer risk.
Regulation of CYP3A4 and CYP3A5 expression and modulation of "intracrine" metabolism of androgens in prostate cells by liganded vitamin D receptor.
Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells.
Relationship Between Aldosterone Synthase CYP1A1 MspI Gene Polymorphism and Prostate Cancer Risk.
Relationship of Early-Onset Baldness to Prostate Cancer in African-American Men.
Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness.
Role of CYP3A5 in Modulating Androgen Receptor Signaling and Its Relevance to African American Men with Prostate Cancer.
Serum persistent organic pollutants (POPs) and prostate cancer risk: A case-cohort study.
Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer.
Structure-function analysis of vitamin D(2) analogs as potential inducers of leukemia differentiation and inhibitors of prostate cancer proliferation.
Substitution at carbon 2 of 19-nor-1?,25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells.
Systematic meta-analyses of gene-specific genetic association studies in prostate cancer.
Targeting of CYP17A1 Lyase by VT-464 Inhibits Adrenal and Intratumoral Androgen Biosynthesis and Tumor Growth of Castration Resistant Prostate Cancer.
The CYP1B1 Leu432Val polymorphism and risk of urinary system cancers.
The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome P450 activity in high passage PC 3 and DU 145 human prostate cancer cell lines.
The interaction of CYP3A5 polymorphisms along the androgen metabolism pathway in prostate cancer.
The prostate cancer TMPRSS2:ERG fusion synergizes with the vitamin D receptor (VDR) to induce CYP24A1 expression-limiting VDR signaling.
The role of drug-drug interactions in prostate cancer treatment: Focus on abiraterone acetate/prednisone and enzalutamide.
The role of oestrogen in the pathogenesis of obesity, type 2 diabetes, breast cancer and prostate disease.
The roles of cytochrome P450 enzymes in prostate cancer development and treatment.
Variant in sex hormone-binding globulin gene and the risk of prostate cancer.
Vitamin D in Prostate Cancer.
Vitamin D Pathway and Other Related Polymorphisms and Risk of Prostate Cancer: Results from the Prostate Cancer Prevention Trial.
Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG.
[Correlation of prostate cancer susceptibility with genetic polymorphism of cytochrome P450 2E1, smoking and drinking: a case-control study in the population of Nanjing area]
[Genotype analysis of CYP1A2 IVS4 + 43A/G in patients with prostate cancer]
[Polymorphism of metabolic gene and genetic susceptibility to prostate cancer]
[Relationship between genetic polymorphisms of metabolizing enzymes and prostate cancer]
[Single nucleotide polymorphisms of CYP1A2 and their correlation with prostate cancer].
[Treatment of metastatic castration-resistant prostate cancer : Drug interaction potentials of abiraterone acetate and enzalutamide].
Protein Deficiency
[Effect of protein on the induction and renewal of a cytochrome P-450 complex in the rat liver]
Protein-Energy Malnutrition
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test.
Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase.
Effects of cysteine on metformin pharmacokinetics in rats with protein-calorie malnutrition: partial restoration of some parameters to control levels.
Effects of cysteine on the pharmacokinetic parameters of omeprazole in rats with protein-calorie malnutrition: partial restoration of some parameters to control levels by oral cysteine supplementation.
Effects of cysteine on the pharmacokinetics of intravenous adriamycin in rats with protein-calorie malnutrition.
Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes.
Proteinuria
CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases.
CYP3A5 and CYP3A7 genetic polymorphisms affect tacrolimus concentration in pediatric patients with nephrotic range proteinuria.
Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.
Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.
Protozoan Infections
Validation of Human Sterol 14?-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors.
Psoriasis
Alterations in leukocyte aryl hydrocarbon hydroxylase activity associated with treatment and age in psoriasis patients and healthy individuals.
An investigation of cytochrome p450 (CYP) and glutathione S-transferase (GST) isoenzyme protein expression and related interactions with phototherapy in patients with psoriasis vulgaris.
Antipyrine clearance and metabolism in patients with psoriasis.
Aryl hydrocarbon hydroxylase activity and psoriasis.
Aryl hydrocarbon hydroxylase activity in psoriasis.
Aryl hydrocarbon hydroxylase and psoriasis.
Aryl hydrocarbon hydroxylase, epoxide hydrolase, and benzo[a]-pyrene metabolism in human epidermis: comparative studies in normal subjects and patients with psoriasis.
Aryl Hydrocarbon Receptor and Autophagy-Related Protein Microtubule-Associated Protein Light Chain 3 Expression in Psoriasis.
Biological products for the treatment of psoriasis: therapeutic targets, pharmacodynamics and disease-drug-drug interaction implications.
Blood monocyte aryl hydrocarbon hydroxylase activity in psoriasis.
Clinical Pharmacokinetics and Pharmacodynamics of Risankizumab in Psoriasis Patients.
Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.
CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway.
CYP2S1 gene polymorphisms in a Korean population.
Decreased epidermal aryl hydrocarbon hydroxylase and localized pustular psoriasis.
Effect of coal tar on cutaneous aryl hydrocarbon hydroxylase induction and anthralin irritancy.
Effect of tildrakizumab (MK-3222), a high affinity, selective anti-IL23p19 monoclonal antibody, on cytochrome P450 metabolism in subjects with moderate to severe psoriasis.
Evaluating Potential Disease-Mediated Protein-Drug Interactions in Patients With Moderate-to-Severe Plaque Psoriasis Receiving Subcutaneous Guselkumab.
Evaluation of Oxidative Stress via Protein Expression of Glutathion S-Transferase and Cytochrome p450 (CYP450) Isoenzymes in Psoriasis Vulgaris Patients Treated with Methotrexate.
Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2.
Generalised tissue abnormality of aryl hydrocarbon hydroxylase in psoriasis.
Hepatic cytochrome P450 CYP2C activity in psoriasis: studies using proguanil as a probe compound.
High-throughput transcriptome and pathogenesis analysis of clinical psoriasis.
Human skin aryl hydrocarbon hydroxylase.
Lack of Effect of 12-Week Treatment with Risankizumab on the Pharmacokinetics of Cytochrome P450 Probe Substrates in Patients with Moderate to Severe Chronic Plaque Psoriasis.
Mast cells express CYP27A1 and CYP27B1 in epithelial skin cancers and psoriasis.
Pharmacokinetics of venlafaxine enantiomers and their metabolites in psoriasis patients.
Secukinumab Treatment Does Not Alter the Pharmacokinetics of the Cytochrome P450 3A4 Substrate Midazolam in Patients With Moderate to Severe Psoriasis.
Serum Levels of Aryl Hydrocarbon Receptor, Cytochromes P450 1A1 and 1B1 in Patients with Exacerbated Psoriasis Vulgaris.
Smoking and Pathogenesis of Psoriasis: A Review of Oxidative, Inflammatory, and Genetic Mechanisms.
Talarozole, a selective inhibitor of P450-mediated all-trans retinoic acid for the treatment of psoriasis and acne.
Therapeutic Protein Drug Interaction Potential in Subjects With Psoriasis: An Assessment Based on Population Pharmacokinetic Analyses of Sensitive Cytochrome P450 Probe Substrates.
Psychomotor Agitation
Antidepressant-induced akathisia-related homicides associated with diminishing mutations in metabolizing genes of the CYP450 family.
Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
The influence of the CYP2D6 polymorphism on psychopathological and extrapyramidal symptoms in the patients on long-term antipsychotic treatment.
Pterygium
An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium.
CYP1A1 gene polymorphisms as a risk factor for pterygium.
CYP1A1 protein activity is associated with allelic variation in pterygium tissues and cells.
Puberty, Precocious
Are CYP1A1, CYP17 and CYP1B1 mutation genes involved on girls with precocious puberty? A pilot study.
Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty.
Pulmonary Arterial Hypertension
Activity of the Estrogen-Metabolizing Enzyme Cytochrome P450 1B1 Influences the Development of Pulmonary Arterial Hypertension.
Dexfenfluramine and the oestrogen metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension.
Lack of Pharmacokinetic Interactions Between Macitentan and a Combined Oral Contraceptive in Healthy Female Subjects.
Metabolism study and biological evaluation of bosentan derivatives.
Potential for pharmacokinetic interactions between ambrisentan and cyclosporine.
The endothelin receptor antagonist macitentan for the treatment of pulmonary arterial hypertension: A cross-species comparison of its cytochrome P450 induction pattern.
Pulmonary Disease, Chronic Obstructive
A Physiologically Based Pharmacokinetic Model to Predict Potential Drug-Drug Interactions and Inform Dosing of Acumapimod, an Oral p38 MAPK Inhibitor.
Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls.
Association of CYP2A6 deletion polymorphism with smoking habit and development of pulmonary emphysema.
Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease.
Association of Functional Variants of Phase I and II Genes with Chronic Obstructive Pulmonary Disease in a Serbian Population.
Association of the CYP1A1 MspI and TNF?-308 polymorphisms with chronic obstructive pulmonary disease in Inner Mongolia.
Clinical pharmacology of cilomilast.
CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD.
CYP1B1, VEGFA, BCL2, and CDKN1A Affect the Development of Chronic Obstructive Pulmonary Disease.
CYP2B6 genetic polymorphisms influence chronic obstructive pulmonary disease susceptibility in the Hainan population.
Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease.
Diallyl disulfide prevents cigarette smoke-induced emphysema in mice.
Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme.
Drug metabolism in severe chronic obstructive pulmonary disease: A phenotyping cocktail study.
Effect of Steady-State Enoxacin on Single-Dose Pharmacokinetics of Roflumilast and Roflumilast N-Oxide.
Effect of verapamil on systemic exposure and safety of umeclidinium and vilanterol: a randomized and open-label study.
Expression of cytochrome P450 mRNAs in Type II alveolar cells from subjects with chronic obstructive pulmonary disease.
Flavonoids isolated from loquat (Eriobotrya japonica) leaves inhibit oxidative stress and inflammation induced by cigarette smoke in COPD mice: the role of TRPV1 signaling pathways.
Genetic Factors Associated with COPD Depend on the Ancestral Caucasian/Amerindian Component in the Mexican Population.
Genetic polymorphisms in chronic obstructive pulmonary disease.
Genetic Polymorphisms of CYP2C9/CYP2C19 in Chronic Obstructive Pulmonary Disease.
Genetic polymorphisms of cytochrome p450 and matrix metalloproteinase in chronic obstructive pulmonary disease.
Genetic variations in detoxification enzymes and HIF-1? in Japanese patients with COPD.
Genome-Wide Association Analysis of Single Breath Diffusing Capacity of Carbon Monoxide (DLCO).
Genome-wide association study of smoking behaviours in patients with COPD.
Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis.
Impact of CYP1A1 Polymorphisms on Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-Analysis.
Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population.
Inter-individual variation in CYP2A6 activity and chronic obstructive pulmonary disease in smokers: Perspectives for an early predictive marker.
The effect of CYP1A2 gene polymorphisms on Theophylline metabolism and chronic obstructive pulmonary disease in Turkish patients.
The effect of diesel emission exposure on primary human bronchial epithelial cells from a COPD cohort: N-acetylcysteine as a potential protective intervention.
The effect of exposure to crude oil on the immune system. Health implications for people living near oil exploration activities.
The Expression Profiles of ADME Genes in Human Cancers and Their Associations with Clinical Outcomes.
Tiotropium bromide. A review of its use as maintenance therapy in patients with COPD.
Update in chronic obstructive pulmonary disease: role of antioxidant and metabolizing gene polymorphisms.
Upregulation of Chitinase 1 in Alveolar Macrophages of HIV-Infected Smokers.
Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms.
[Association of cytochrome P450 genes polymorphisms (CYP1A1 and CYP1A2) with the development of chronic obstructive pulmonary disease in Bashkortostan]
[Association of the nicotine and cigarette smoke toxicants metabolic (CHRNA3/5, CYP2A6, NQO1) and DNA repair genes (XRCC1, XRCC3, XPC, XPA) with chronic obstructive pulmonary disease].
[Genetic risk factors for chronic obstructive pulmonary disease (COPD)]
[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]
[The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disease patients]
Pulmonary Edema
Induction and decline of hepatic cytochromes P4501A1 and 1A2 in rats exposed to hyperoxia are not paralleled by changes in glutathione S-transferase-alpha.
Xylazine-induced pulmonary edema in rats.
Pulmonary Embolism
ARMS test for diagnosis of CYP2C9 and VKORC1 mutation in patients with pulmonary embolism in Han Chinese.
Comparison of rivaroxaban mono-therapy and standard-therapy adjusted by CYP2C9 and VKORC1 genotypes in symptomatic pulmonary embolism.
Pulmonary Emphysema
Association between the CYP1A1 gene polymorphism and susceptibility to emphysema and lung cancer.
Association of CYP2A6 deletion polymorphism with smoking habit and development of pulmonary emphysema.
Pulmonary Fibrosis
CYP2E1 regulates the development of radiation-induced pulmonary fibrosis via ER stress- and ROS-dependent mechanisms.
VKORC1 and CYP2C9 Polymorphisms: A Case Report in a Dutch Family with Pulmonary Fibrosis.
quinine 3-monooxygenase deficiency
Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.
receptor protein-tyrosine kinase deficiency
Use of c-Src and c-Fos knockout mice for the studies on the role of c-Src kinase signaling in the expression of toxicity of TCDD.
Rectal Neoplasms
Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk.
CYP1A1, cigarette smoking, and colon and rectal cancer.
CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.
CYP2E1 RsaI and 96-bp insertion genetic polymorphisms associated with risk for colorectal cancer.
Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean population.
Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study.
Red meat intake, CYP2E1 genetic polymorphisms, and colorectal cancer risk.
Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii.
[Genetic polymorphism in cytochrome P450 2E1, salted food and colorectal cancer susceptibility: a case-control study]
REM Sleep Behavior Disorder
A Stage-Based Approach to Therapy in Parkinson's Disease.
Renal Insufficiency
Apremilast (Otezla). No progress in plaque psoriasis or psoriatic arthritis.
Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: comparison of sparteine and dextromethorphan.
Association of plasma concentration of 4?-hydroxycholesterol with CYP3A5 polymorphism and plasma concentration of indoxyl sulfate in stable kidney transplant recipients.
Colchicine: serious interactions.
Concomitant use of statins and macrolide antibiotics and risk of serious renal events: A nationwide cohort study.
Determination of dextromethorphan metabolic phenotype by salivary analysis with a reference to genotype in Chinese patients receiving renal hemodialysis.
Drug metabolism and ageing.
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation.
Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport.
Influence of renal failure on cytochrome P450 activity in hypertensive patients using a "cocktail" of antipyrine and nifedipine.
Pharmacodynamic and pharmacokinetic considerations in geriatric psychopharmacology.
Pregabalin: new drug. Very similar to gabapentin.
Renal insufficiency has no effect on the pharmacokinetics of vicriviroc in a ritonavir-containing regimen.
The hepatic and intestinal metabolic activities of P450 in rats with surgery- and drug-induced renal dysfunction.
The pharmacokinetics of paliperidone versus risperidone.
[Fibrate and statine myopathy]
[Pharmacokinetics and pharmacodynamics of new oral anticoagulants.]
[Resistance to Antiplatelet Substances - a Real Clinical Problem.]
Renal Insufficiency, Chronic
25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D.
Assessment of 24,25(OH)(2)D levels does not support FGF23-mediated catabolism of vitamin D metabolites.
Assessment of oral anticoagulation control at pharmacist-managed clinics: A retrospective cohort study.
Association of CYP1A1 gene polymorphism with chronic kidney disease: a case control study.
Calcium pyrophosphate deposition disease revealing a hypersensitivity to vitamin D.
Combined sequence and sequence-structure based methods for analyzing FGF23, CYP24A1 and VDR genes.
CYP24A1 and kidney disease.
Derivation, Validation, and Prognostic Utility of a Prediction Rule for Nonresponse to Clopidogrel: The ABCD-GENE Score.
Differential methylation pattern of xenobiotic metabolizing genes and susceptibility to Balkan endemic nephropathy, in a cohort of Romanian patients.
Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP.
Effect of erythropoietin on hepatic cytochrome P450 expression and function in an adenine-fed rat model of chronic kidney disease.
Effects of CYP3A5 Polymorphism on Rapid Progression of Chronic Kidney Disease: A Prospective, Multicentre Study.
Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease.
Genetic variance in ABCB1 and CYP3A5 does not contribute toward the development of chronic kidney disease after liver transplantation.
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
In silico identification and screening of CYP24A1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis.
Pharmacogenomic associations in ABCB1 and CYP3A5 with acute kidney injury and chronic kidney disease after myeloablative hematopoietic cell transplantation.
Pharmacokinetics of Tecarfarin and Warfarin in Patients with Severe Chronic Kidney Disease.
Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.
Systematic and quantitative assessment of the effect of chronic kidney disease on CYP2D6 and CYP3A4/5.
The effect of chronic kidney disease on CYP2B expression and activity in male Wistar rats.
The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D catabolism, is reduced in chronic kidney disease.
Use of Enantiomeric Bupropion and Hydroxybupropion to Assess CYP2B6 Activity in Glomerular Kidney Diseases.
Use of physiologically-based pharmacokinetic (PBPK) modeling to evaluate the effect of chronic kidney disease on the disposition of hepatic CYP2C8 and OATP1B drug substrates.
Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism.
Reperfusion Injury
Accumulation of cytochrome P450 induced by proteasome inhibition during cardiac ischemia.
Alternative cyclosporine metabolic pathways and toxicity.
Arterial ketone index in assessing liver function and its detoxicative capability after ischemia-reperfusion injury.
Carbon monoxide-bound red blood cell resuscitation ameliorates hepatic injury induced by massive hemorrhage and red blood cell resuscitation via hepatic cytochrome P450 protection in hemorrhagic shock rats.
Cardioprotection by sulfaphenazole, a cytochrome p450 inhibitor: mitigation of ischemia-reperfusion injury by scavenging of reactive oxygen species.
Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats.
Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.
Cytochrome P450 CYP2E1 Suppression Ameliorates Cerebral Ischemia Reperfusion Injury.
Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers.
Cytochrome P450 metabolites of arachidonic acid play a role in the enhanced cardiac dysfunction in diabetic rats following ischaemic reperfusion injury.
Cytochrome P450 omega-hydroxylase inhibition reduces cardiomyocyte apoptosis via activation of ERK1/2 signaling in rat myocardial ischemia-reperfusion.
Cytochrome P450: major player in reperfusion injury.
Effects of Cytochrome P450 Inhibition by Cimetidine on the Warm Hepatic Ischemia-Reperfusion Injury in Rats.
Effects of normothermic hepatic ischemia-reperfusion injury on the in vivo, isolated perfused liver, and microsomal disposition of chlorzoxazone, a cytochrome P450 2E1 probe, in rats.
Effects of sulfaphenazole derivatives on cardiac ischemia-reperfusion injury: association of cytochrome P450 activity and infarct size.
Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart.
Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.
Inhibition of cardiac cytochrome P450: a new approach to cardiac ischaemia and reperfusion damage.
Is it possible to predict the early post-transplant allograft function using 20-HETE measurements? A preliminary report.
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.
Suppression of myocardial ischemia-reperfusion injury by inhibitors of cytochrome P450 in rats.
[Effect of "Jiaji" (EX-B2)-electroacupuncture preconditioning on expression of myocardial cytochrome P450 enzyme in rats with acute myocardial ischemia-reperfusion injury].
Respiratory Distress Syndrome
CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications.
Genetic susceptibility to nosocomial pneumonia, acute respiratory distress syndrome and poor outcome in patients at risk of critical illness.
Respiratory Distress Syndrome, Newborn
Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2.
Respiratory Insufficiency
A Case of Respiratory Depression in a Child With Ultrarapid CYP2D6 Metabolism After Tramadol.
CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications.
Drug-drug interactions and clinical considerations with co-administration of antiretrovirals and psychotropic drugs.
Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication.
Respiratory Tract Diseases
[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]
Respiratory Tract Infections
Herbal extracts used for upper respiratory tract infections: are there clinically relevant interactions with the cytochrome P450 enzyme system?
Serious respiratory infections can increase clozapine levels and contribute to side effects: a case report.
Retinal Degeneration
Aryl hydrocarbon hydroxylase induction in retinal pigmented epithelium: possible association of genetic differences in a drug-metabolizing enzyme system with retinal degeneration.
Ethanol-Induced Oxidative Stress Modifies Inflammation and Angiogenesis Biomarkers in Retinal Pigment Epithelial Cells (ARPE-19): Role of CYP2E1 and its Inhibition by Antioxidants.
Opposite expression of CYP51A1 and its natural antisense transcript AluCYP51A1 in adenovirus type 37 infected retinal pigmented epithelial cells.
Oxysterols: functional significance in fetal development and the maintenance of normal retinal function.
retinal dehydrogenase deficiency
Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression levels.
Retinal Diseases
New Lipid Mediators in Retinal Angiogenesis and Retinopathy.
Retinal Dystrophies
Expanding the Phenotypic and Genotypic Spectrum of Bietti Crystalline Dystrophy.
Retinal Neoplasms
[EXOPHTHALMOS, EXCEPTIONAL REVELATORY SIGN OF A TUMOR OF THE OLFACTIVE PLACODE. ESTHESIONEUROEPITHELIOMA. HISTOLOGICAL RELATION OF THIS TUMOR TO NERVOUS RETINAL TUMORS.]
Retinal Neovascularization
CYP1B1: A key regulator of redox homeostasis.
Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization.
Targeted deletion of Cyp1b1 in pericytes results in attenuation of retinal neovascularization and trabecular meshwork dysgenesis.
Retinitis Pigmentosa
Research progress on human genes involved in the pathogenesis of glaucoma (Review).
Retrognathia
Parathyroid Hormone Gene and Genes Involved in the Maintenance of Vitamin D Levels Association with Mandibular Retrognathism.
Rhabdomyolysis
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and rhabdomyolysis: considerations in the renal failure patient.
A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin.
A Screening Study of Drug-Drug Interactions in Cerivastatin Users: An Adverse Effect of Clopidogrel.
Alcohol-associated rhabdomyolysis: ethanol induction of cytochrome P450 may potentiate myotoxicity.
Atorvastatin-related rhabdomyolysis and acute renal failure in a genetically predisposed patient with potential drug-drug interaction.
Cerivastatin in vitro metabolism by CYP2C8 variants found in patients experiencing rhabdomyolysis.
Cerivastatin, genetic variants, and the risk of rhabdomyolysis.
Clarification of the Mechanism of Clopidogrel-Mediated Drug-Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information.
Fusidic Acid Inhibits Hepatic Transporters and Metabolic Enzymes: Potential Cause of Clinical Drug-Drug Interaction Observed with Statin Coadministration.
HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles.
Major Cardiac-Psychiatric Drug-Drug Interactions: a Systematic Review of the Consistency of Drug Databases.
Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management.
Rhabdomyolysis and acute renal failure in a cardiac transplant recipient due to multiple drug interactions.
Rhabdomyolysis and interferon-?: case report and short review.
Rhabdomyolysis associated with pomegranate juice consumption.
Rhabdomyolysis following co-prescription of fusidic acid and atorvastatin.
Rhabdomyolysis in an elderly multitreated patient: multiple drug interactions after statin withdrawal.
Rhabdomyolysis in an HIV-Infected Patient on Anti-Retroviral Therapy Precipitated by High-Dose Pravastatin.
Rhabdomyolysis precipitated by possible interaction of ticagrelor with high-dose atorvastatin.
Risk management of simvastatin or atorvastatin interactions with CYP3A4 inhibitors.
Rosuvastatin-induced rhabdomyolysis probably via CYP2C9 saturation.
Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin with rapamycin plus tacrolimus in liver transplant patient.
Severe Rhabdomyolysis due to Presumed Drug Interactions between Atorvastatin with Amlodipine and Ticagrelor.
Short term treatment with clarithromycin resulting in colchicine-induced rhabdomyolysis.
Simvastatin-fluconazole causing rhabdomyolysis.
Statin safety: an assessment using an administrative claims database.
The Case-Crossover Design for Drug-Drug Interactions: Considerations for Implementation.
Ticagrelor and Statin Interaction Induces Rhabdomyolysis and Acute Renal Failure: Case reports and Scoping Review.
When Should Statins Be Stopped?
[Rhabdomyolysis in patients treated with simvastatin and cyclosporin: role of the hepatic cytochrome P450 enzyme system activity]
Rhabdomyosarcoma
Differential expression of cytochrome p450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma.
Rheumatic Diseases
CYP-derived eicosanoids: Implications for rheumatoid arthritis.
Cytochrome P450 interactions and clinical implication in rheumatology.
Lack of pharmacokinetic interaction between pantoprazole and diclofenac.
Rheumatic Heart Disease
Clinical application of pharmacogenetic-based warfarin-dosing algorithm in patients of han nationality after rheumatic valve replacement: a randomized and controlled trial.
Rhinitis, Allergic
[Significance of CYP2D6 oxidation genotype as a risk factor in development of allergic diseases]
Riboflavin Deficiency
Hepatic drug metabolism during ethanol ingestion in riboflavin deficient rats.
Phenobarbital induced variations in hepatic ethyl-morphine n-demethylase and inorganic pyrophosphatase during riboflavin deficiency.
Possible role of riboflavin deficiency in epithelial neoplasia. 3. Induction of microsomal aryl hydrocarbon hydroxylase.
Rickets
Enzymes involved in the activation and inactivation of vitamin D.
Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D-deficient rickets.
Relationship between polymorphisms in vitamin D metabolism-related genes and the risk of rickets in Han Chinese children.
Structure-function analysis of CYP27B1 and CYP27A1. Studies on mutants from patients with vitamin D-dependent rickets type I (VDDR-I) and cerebrotendinous xanthomatosis (CTX).
Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets.
The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus.
Rickets, Hypophosphatemic
Pruning the ricket thicket.
Sarcoidosis
Iatrogenic vitamin D toxicity in an infant - a case report and review of literature.
Personalized medicine in sarcoidosis: predict responders and nonresponders.
Sarcoma
A comparison between lung carcinoma and a subcutaneous malignant tumor induced in rats by a 3,4-benzopyrene injection.
Aromatase cytochrome P450 and estrogen and progesterone receptors in uterine sarcomas: correlation with clinical parameters.
Cytochrome P450 expression is a common molecular event in soft tissue sarcomas.
Rank order of sarcoma susceptibility among mouse strains reverses with low concentrations of carcinogen.
Relationships between aryl hydrocarbon hydroxylase inducibility and sensitivity to chemically induced subcutaneous sarcomas in various strains of mice.
Sarcoma, Avian
Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver.
Mammalian PC-12 cell genetically engineered for human cytochrome P450 2E1 expression.
Sarcoma, Ewing
Immunostimulation by OX40 Ligand Transgenic Ewing Sarcoma Cells.
Sarcoma, Experimental
Maturation of fetal hepatocytes in vitro by extracellular matrices and oncostatin M: induction of tryptophan oxygenase.
Sarcoma, Kaposi
Pilot study evaluating the interaction between paclitaxel and protease inhibitors in patients with human immunodeficiency virus-associated Kaposi's sarcoma: an Eastern Cooperative Oncology Group (ECOG) and AIDS Malignancy Consortium (AMC) trial.
Scabies
Biosynthesis and evolution of coronafacoyl phytotoxin production in the common scab pathogen Streptomyces scabies.
Structural insights into the mechanism for recognizing substrate of the cytochrome P450 enzyme TxtE.
Schistosomiasis
Changes in the expression of cytochrome P450 isozymes and related carcinogen metabolizing enzyme activities in Schistosoma mansoni-infected mice.
Different levels of Schistosoma mansoni infection induce changes in drug-metabolizing enzymes.
Schistosomiasis haematobia
Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts.
Schistosomiasis mansoni
Changes in the expression of cytochrome P450 isozymes and related carcinogen metabolizing enzyme activities in Schistosoma mansoni-infected mice.
Different levels of Schistosoma mansoni infection increased the mutagenicity of benzo(a)pyrene, the activity of aryl hydrocarbon hydroxylase and the formation of hepatic microsomal hydrogen peroxide.
Scleroderma, Systemic
Enantioselectivity in the Metabolism of Cyclophosphamide in Patients With Multiple or Systemic Sclerosis.
Genetic polymorphism of CYP2D6 in patients with systemic lupus erythematosus and systemic sclerosis.
Genetic polymorphisms of CYP2D6 oxidation in patients with systemic sclerosis.
Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus.
Significance of genetic polymorphism of CYP2D6 in the pathogenesis of systemic sclerosis.
Scrapie
Comprehensive gene expression analysis in human periodontal ligaments of the mandibular third molars performing vertical movement and the maxillary second premolars with occlusal contact.
Seizures
A puzzling case of seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration.
Acute toxic effects of polyethylene microplastic on adult zebrafish.
Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and ?-Subunit-Containing Gamma-Aminobutyric Acid A Receptors.
Association of CYP2D6 100 C > T and 2850 C > T polymorphisms with generalized tonic clonic seizures among Indians.
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism.
Bupropion.
Clozapine pharmacokinetics and pharmacodynamics studied with Cyp1A2-null mice.
Correspondence of increased debrisoquine 4-monooxygenase activity with seizure-susceptibility in Mongolian gerbils.
Early post-traumatic seizures are associated with valproic acid plasma concentrations and UGT1A6/CYP2C9 genetic polymorphisms in patients with severe traumatic brain injury.
Effect of lindane on hepatic and brain cytochrome P450s and influence of P450 modulation in lindane induced neurotoxicity.
Effects of cytochrome P450 (CYP)2C19 polymorphisms on pharmacokinetics of phenobarbital in neonates and infants with seizures.
Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions.
Genetic polymorphisms in sex hormone metabolizing genes and drug response in women with epilepsy.
Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N?=?1345 young and elderly subjects.
Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.
Herbal medicine and epilepsy: proconvulsive effects and interactions with antiepileptic drugs.
Induction of pulmonary cytochrome P4501A1: interactive effects of nicotine and mecamylamine.
Induction or inhibition of cytochrome P450 2E1 modifies the acute toxicity of acrylonitrile in rats: biochemical evidence.
Lacosamide serum concentrations during pregnancy.
Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin.
Maternal intake of docosahexaenoic acid decreased febrile seizure sensitivity by increasing estrogen synthesis in offspring.
P450 enzyme-inducing and non-enzyme-inducing antiepileptic drugs for seizure prophylaxis after glioma resection surgery: a meta-analysis.
Phenytoin: an evaluation of several potential teratogenic mechanisms.
Potentiation of 17?-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid.
Reproductive dysfunction in women with epilepsy: antiepileptic drug effects on sex-steroid hormones.
Seizures and myoclonus associated with antidepressant treatment: assessment of potential risk factors, including CYP2D6 and CYP2C19 polymorphisms, and treatment with CYP2D6 inhibitors.
Seizures associated with levofloxacin: case presentation and literature review.
Seizures associated with therapeutic doses of venlafaxine and trimipramine.
Susceptibility to the acute toxicity of acrylonitrile in streptozotocin-induced diabetic rats: protective effect of phenethyl isothiocyanate, a phytochemical CYP2E1 inhibitor.
The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients.
[Contraception in epileptic women].
Seminoma
Cytochrome P450 aromatase expression in human seminoma.
Low CYP1A2 activity associated with testicular cancer.
Sepsis
A role for one or more p450 enzymes in the response to sepsis.
Correction to: Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis.
Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis.
Cytochrome P450 activity mirrors nitric oxide levels in postoperative sepsis: predictive indicators of lethal outcome.
Differential expression of cytochrome P450 isoforms in the lungs of septic animals.
Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis.
Downregulation of hepatic cytochrome P-450 isoforms and PPAR-gamma: their role in hepatic injury and proinflammatory responses in a double-hit model of hemorrhage and sepsis.
Drug metabolism and ageing.
Effect of SPG/Indomethacin treatment on sepsis, interleukin-6 production, and expression of hepatic cytochrome P450 isoforms in differing strains of mice.
Genetic variations in multiple myeloma II: association with effect of treatment.
Maternal-fetal and neonatal pharmacogenomics: a review of current literature.
Metabolism-mediated drug interaction potential of HS-23, a new herbal drug for the treatment of sepsis in human hepatocytes and liver microsomes.
Mixed-function oxidase activity in sepsis.
Myocardial transcriptional profiles in a murine model of sepsis: evidence for the importance of age.
Nitric oxide mediates hepatic cytochrome P450 dysfunction induced by endotoxin.
On the Role of Illness Duration and Nutrient Restriction in Cholestatic Alterations that Occur During Critical Illness.
Pharmacokinetics and pharmacodynamics of vecuronium in rats with systemic inflammatory response syndrome: treatment with NG-monomethyl-L-arginine.
Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction.
Role of nitric oxide in the inhibition of liver cytochrome P450 during sepsis.
Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats.
Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: the central role of proinflammatory cytokines.
The beneficial effect of Trolox on sepsis-induced hepatic drug metabolizing dysfunction.
The effect of sepsis during parenteral nutrition on hepatic microsomal function in rats.
The potential role of transcription factor aryl hydrocarbon receptor in downregulation of hepatic cytochrome P-450 during sepsis.
Vitamins C and E protect hepatic cytochrome P450 dysfunction induced by polymicrobial sepsis.
Xenobiotic receptors in mediating the effect of sepsis on drug metabolism.
Sertoli Cell-Only Syndrome
Disturbed testicular expression of the estrogen-metabolizing enzymes CYP1A1 and COMT in infertile men with primary spermatogenic failure: possible negative implications on Sertoli cells.
Transcripts of testicular gonadotropin-releasing hormone, steroidogenic enzymes, and intratesticular testosterone levels in infertile men.
Sertoli-Leydig Cell Tumor
Expression of P450 Aromatase in Granulosa Cell Tumors and Sertoli-Stromal Cell Tumors of the Ovary: Which Cells Are Responsible for Estrogenesis?
Immunohistochemical studies of steroidogenic enzymes (aromatase, 17 alpha-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary.
Severe Acute Respiratory Syndrome
The -omics era and its impact.
Sex Cord-Gonadal Stromal Tumors
Expression of P450 Aromatase in Granulosa Cell Tumors and Sertoli-Stromal Cell Tumors of the Ovary: Which Cells Are Responsible for Estrogenesis?
Sexual Infantilism
Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.
Shock, Cardiogenic
Cardiogenic shock induced by bisoprolol in a patient with CYP2D6 variant. A case report.
Midazolam Intoxication in a Premature Neonate.
Shock, Septic
Bexarotene, a Selective RXR? Agonist, Reverses Hypotension Associated with Inflammation and Tissue Injury in a Rat Model of Septic Shock.
Hepatic oxygen consumption and cytochrome P450 activity in experimental faecal peritonitis.
Silicosis
CYP1A1 and CYP1B1 polymorphisms as modifying factors in patients with pneumoconiosis and occupationally related tumours: A pilot study.
Skin Diseases
2,3,7,8-Tetrachlorodibenzo-p-Dioxin Regulates the Expression of Aryl Hydrocarbon Receptor-Related Factors and Cytokines in Peripheral Blood Mononuclear Cells and CD4+ T cells from Patients with Atopic Dermatitis and Psoriasis.
Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.
CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway.
Cytochrome p450: a target for drug development for skin diseases.
Molecular docking of substrates and inhibitors in the catalytic site of CYP6B1, an insect cytochrome p450 monooxygenase.
Skin Neoplasms
Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways.
Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond.
Epigenetic and genetic dissections of UV-induced global gene dysregulation in skin cells through multi-omics analyses.
Glutathione S-transferase and CYP1A1 gene polymorphisms and non-melanoma skin cancer risk in Italian transplanted patients.
Immunoreactivity to CYP24A1, but not vitamin D receptor, is increased in mast cells of keratinocyte skin cancers.
Mast cells express CYP27A1 and CYP27B1 in epithelial skin cancers and psoriasis.
Retinoic acid antagonizes basal as well as coal tar and glucocorticoid-induced cytochrome P4501A1 expression in human skin.
Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1.
Sleep Apnea Syndromes
Decreased expression of hepatic cytochrome P450 1A2 (CYP1A2) in a chronic intermittent hypoxia mouse model.
Sleep Apnea, Obstructive
A Case of Respiratory Depression in a Child With Ultrarapid CYP2D6 Metabolism After Tramadol.
Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer.
More codeine fatalities after tonsillectomy in North American children.
Sleep Deprivation
Changes in the expression of steroid metabolism-related genes in rat adrenal glands during selective REM sleep deprivation.
Sleep Initiation and Maintenance Disorders
Effects of genetic polymorphisms of CYP2C19 on the pharmacokinetics of zolpidem.
Pharmacogenetic Associations Between Atazanavir/UGT1A1*28 and Efavirenz/rs3745274 (CYP2B6) Account for Specific Adverse Reactions in Chilean Patients Undergoing Antiretroviral Therapy.
Pharmacokinetic Interactions Between the Orexin Receptor Antagonist Almorexant and the CYP3A4 Inhibitors Ketoconazole and Diltiazem.
Physiologically-based pharmacokinetic modeling to predict drug interactions of lemborexant with CYP3A inhibitors.
Sensory gating in primary insomnia.
Small Cell Lung Carcinoma
Altered regulation of the cytochrome P4501A1 gene: novel inducer-independent gene expression in pulmonary carcinoma cell lines.
CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population.
Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines.
[Applications of aryl hydrocarbon hydroxylase in diagnosis of lung cancer]
[Association of CYP1A1 Ile462Val polymorphisms with susceptibility to small cell lung cancer].
Smith-Lemli-Opitz Syndrome
Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.
Spastic Paraplegia, Hereditary
CYP7B1: novel mutations and magnetic resonance spectroscopy abnormalities in hereditary spastic paraplegia type 5A.
Generation of induced pluripotent stem cells (iPSCs) from a hereditary spastic paraplegia patient carrying a homozygous R486C mutation in CYP7B1 (SPG5).
Generation of induced pluripotent stem cells (iPSCs) from a hereditary spastic paraplegia patient carrying a homozygous Y275X mutation in CYP7B1 (SPG5).
Mining for Oxysterols in Cyp7b1-/- Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5.
Structural and dynamic basis of human cytochrome P450 7B1: a survey of substrate selectivity and major active site access channels.
Spondylitis, Ankylosing
Association between Functional CYP2D6 Polymorphisms and Susceptibility to Autoimmune Diseases: A Meta-Analysis.
Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis.
Influence of CYP2C9 and COX-2 Genetic Polymorphisms on Clinical Efficacy of Non-Steroidal Anti-Inflammatory Drugs in Treatment of Ankylosing Spondylitis.
Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis.
Relationship between genotype for the cytochrome P450 CYP2D6 and susceptibility to ankylosing spondylitis and rheumatoid arthritis.
Squamous Cell Carcinoma of Head and Neck
Analysis of RNA from brush cytology detects changes in B2M, CYP1B1 and KRT17 levels with OSCC in tobacco users.
Anticancer effects of NSC?631570 (Ukrain) in head and neck cancer cells: In vitro analysis of growth, invasion, angiogenesis and gene expression.
Association and treatment response to capecitabine-based chemoradiotherapy with CYP2C9 polymorphism in head and neck cancer.
Association between CYP1A1 Ile462Val Polymorphism and Oral Squamous Cell Carcinoma Susceptibility: Evidence from 13 Investigations.
Association between GSTM1 and CYP1A1 polymorphisms and survival in oral cancer patients.
Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue.
Association of cytochrome P450 1B1 haplotypes with head and neck cancer risk.
Association of cytochrome P450 2C9 polymorphism with locally advanced head and neck squamous cell carcinoma and response to concurrent cisplatin-based radical chemoradiation.
Association of cytochrome P450 2E1 polymorphisms and head and neck squamous cell cancer.
Association of Genetic Polymorphisms of Aldehyde Dehydrogenase-2 and Cytochrome P450 2E1-RsaI and Alcohol Consumption with Oral Squamous Cell Carcinoma.
Association of polymorphism in cytochrome P450 2C9 with susceptibility to head and neck cancer and treatment outcome.
Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes.
CYP1A1 and GSTP1 polymorphisms in an oral cancer case-control study.
CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx.
CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta-analysis.
CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma.
CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma.
CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients.
Cytochrome P450 2E1 and head and neck cancer: Interaction with genetic and environmental risk factors.
Differential induction of CYP1A1 and CYP1B1 by benzo[a]pyrene in oral squamous cell carcinoma cell lines and by tobacco smoking in oral mucosa.
Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis.
Evaluation of CYP1B1 Expression, Oxidative Stress and Phase 2 Detoxification Enzyme Status in Oral Squamous Cell Carcinoma Patients.
Expression and Possible Molecular Mechanisms of microRNA-205-5p in Patients With Head and Neck Squamous Cell Carcinoma.
Expression profiling of CYP1B1 in oral squamous cell carcinoma: counterintuitive downregulation in tumors.
Gene polymorphisms in detoxification enzymes as susceptibility factor for head and neck cancer?
Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use.
Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population.
Genetic polymorphisms in Cytochrome P4501B1 and susceptibility to Head and Neck Cancer.
Genetic Polymorphisms of ADH1C and CYP2E1 and Risk of Oral Squamous Cell Carcinoma.
Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes.
Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions.
Head and neck squamous-cell cancer and its association with polymorphic enzymes of xenobiotic metabolism and repair.
Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.
Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response.
Lack of association among polymorphic xenobiotic-metabolizing enzyme genotypes and the occurrence and progression of oral carcinoma in a Brazilian population.
Meta-analyses of the effect of CYP1A1 and CYP2D6 polymorphisms on the risk of head and neck squamous cell carcinoma.
miR?543 acts as a novel oncogene in oral squamous cell carcinoma by targeting CYP3A5.
p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use.
Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome.
Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer.
Polymorphisms of GSTT1 and related genes in head and neck cancer risk.
Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk.
Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose.
Prognostic value of lipid metabolism-related genes in head and neck squamous cell carcinoma.
Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinoma.
Quantitative assessment of the influence of CYP1B1 polymorphisms and head and neck squamous cell carcinoma risk.
Screening and analysis of pathogenic genes during DMBA-induced buccal mucosa carcinogenesis in golden hamsters.
Study the polymorphism of CYP3A5 and CYP3A4 loci in Iranian population with laryngeal squamous cell carcinoma.
Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator.
Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population.
[Initial results of glutathione-S-transferase GSTM1 and GSTT1 genotypes and genetic predisposition for laryngeal carcinoma]
Stargardt Disease
Cytochrome P450 2C Epoxygenases Mediate Photochemical Stress-induced Death of Photoreceptors.
Starvation
Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect.
Changes in the amount of cytochrome P450s in rat hepatic microsomes with starvation.
Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver.
Combination treatment of epilepsy with ketogenic diet and concurrent pharmacological inhibition of cytochrome P450 2E1.
Concentration-dependent changes of PCB patterns in fish-eating mammals: structural evidence for induction of cytochrome P450.
Cytochrome P450 family 4 in a cockroach: molecular cloning and regulation by regulation by hypertrehalosemic hormone.
Effect of nicotine or cotinine on metabolism of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in isolated rat lung and liver.
Effect of polychlorinated biphenyls (Aroclor 1254) on inducible and repressible microsomal N-demethylases in the mouse and rat.
Effect of starvation and chlormethiazole on cytochrome P450s of rat nasal mucosa.
Effects of starvation on liver microsomal P450 activity in juvenile Pleuronectes americanus.
Expression and distribution of cytochrome P450 enzymes in male rat kidney: effects of ethanol, acetone and dietary conditions.
Hypergravity modulates vitamin D receptor target gene mRNA expression in mice.
Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury.
Induction and regulation of cytochrome P450 K-5 (lauric acid hydroxylase) in rat renal microsomes by starvation.
Induction mechanisms of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation.
Lack of cytochrome P450 2E1 (CYP2E1) induction in the rat liver by starvation without coprophagy.
Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009).
The effect of short-term starvation or water deprivation on caffeine pharmacokinetics in calves.
The regulation by gender, strain, dose, and feeding status of the induction of multiple forms of cytochrome P450 isozymes in rat hepatic microsomes by 2,4,5,2',4',5'-hexachlorobiphenyl.
Transcriptional control of CYP2E1 in the perivenous liver region and during starvation.
Transcriptional responses to starvation stress in the hepatopancreas of oriental river prawn Macrobrachium nipponense.
Transcriptomic profiles of Heterobasidion annosum under abiotic stresses and during saprotrophic growth in bark, sapwood and heartwood.
Undernutrition during hyperoxic exposure induces CYP2E1 in rat liver.
[Effect of starvation and acetone on the enzyme systems of biotransformation and toxicity of xenobiotics--CYP2E1 substrates in rats]
Status Epilepticus
Anticonvulsant Activity of Enantiomeric N-trans-Cinnamoyl Derivatives of 2-Aminopropan-1-ols and 2-Aminobutan-1-ols.
Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression.
Status Epilepticus Decreases Brain Cytochrome P450 2D4 Expression in Rats.
steroid 17alpha-monooxygenase deficiency
Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility.
Successful Delivery in 17,20-Lyase Deficiency.
steroid 21-monooxygenase deficiency
Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone.
Antipyrine clearance in congenital adrenal hyperplasia.
Clinical presentation and mutational spectrum in a series of 166 patients with classical 21-hydroxylase deficiency from South China.
Functional characterization of two novel point mutations in the CYP21 gene causing simple virilizing forms of congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Glucocorticoid-induced osteoporosis in children with 21-hydroxylase deficiency.
Junction site analysis of chimeric CYP21A1P/CYP21A2 genes in 21-hydroxylase deficiency.
Protein kinase A, protein kinase C, and Ca(2+)-regulated expression of 21-hydroxylase cytochrome P450 in H295R human adrenocortical cells.
Restoration of adrenal steroidogenesis by adenovirus-mediated transfer of human cytochromeP450 21-hydroxylase into the adrenal gland of21-hydroxylase-deficient mice.
Why is management of patients with classical congenital adrenal hyperplasia more difficult at puberty?
Stevens-Johnson Syndrome
CYP2C9 polymorphisms in epilepsy: influence on phenytoin treatment.
Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes.
ORAL ADVERSE DRUG REACTIONS TO CARDIOVASCULAR DRUGS.
Stillbirth
Stillbirth and slow metabolizers of caffeine: comparison by genotypes.
Stomach Neoplasms
A phase II study of perioperative S-1 combined with weekly docetaxel in patients with locally advanced gastric carcinoma: clinical outcomes and clinicopathological and pharmacogenetic predictors for survival.
A randomized phase II study of S-1 versus capecitabine as first-line chemotherapy in elderly metastatic gastric cancer patients with or without poor performance status: clinical and pharmacogenetic results.
Alteration of cytochrome P-450 and glutathione S-transferase activity in normal and malignant human stomach.
Analysis of CYP2E1 polymorphism for the determination of genetic susceptibility to gastric cancer in Koreans.
Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta-analysis of 32 case-control studies.
Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of stomach cancer: a hospital-based case-control study in Japan.
Association of CYP2A6 gene deletion with cancers in Japanese elderly: an autopsy study.
Association of CYP2A6 polymorphisms with S-1 plus docetaxel therapy outcomes in metastatic gastric cancer.
Associations between CYP2A6 polymorphisms and outcomes of adjuvant S-1 chemotherapy in patients with curatively resected gastric cancer.
Bioinformatics analysis to identify action targets in NCI-N87 gastric cancer cells exposed to quercetin.
Concurrent expression of aryl hydrocarbon receptor and CYP1A1 but not CYP1A1 MspI polymorphism is correlated with gastric cancers raised in Dalian, China.
CYP1A1, CYP2E1, and GSTM1 Gene Polymorphisms and Susceptibility to Colorectal and Gastric Cancer Among Lebanese.
CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case-control study within a large-scale population-based prospective study.
CYP2A6 and ERCC1 polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients.
CYP2A6 Polymorphisms Associate with Outcomes of S-1 Plus Oxaliplatin Chemotherapy in Chinese Gastric Cancer Patients.
CYP2E1 changes the biological function of gastric cancer cells via the PI3K/Akt/mTOR signaling pathway.
CYP2E1 genetic polymorphism with dietary, tobacco, alcohol habits, H. pylori infection status and susceptibility to stomach cancer in Mizoram, India.
CYP2E1 RsaI/PstI polymorphism and gastric cancer susceptibility: meta-analyses based on 24 case-control studies.
CYP2E1PstI/RsaI polymorphism and interaction with tobacco, alcohol and GSTs in gastric cancer susceptibility: A meta-analysis of the literature.
Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle, Fujian Province.
Cytochrome P450 2E1 polymorphism in gastric cancer in Brazil: case-control studies of Japanese Brazilians and non-Japanese Brazilians.
Cytochrome P450 aromatase gene (CYP19) expression in gastric cancer.
Dietary aflatoxin B1 intake, genetic polymorphisms of CYP1A2, CYP2E1, EPHX1, GSTM1, and GSTT1, and gastric cancer risk in Korean.
Effects of cytochrome P450 (CYP) 2A6 gene deletion and CYP2E1 genotypes on gastric adenocarcinoma.
Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer.
Enhanced expression of cytochrome P450 in stomach cancer.
Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population.
Frequent CYP1A1 expression in gastric cancers and their related lesions.
Functional PstI/RsaI Polymorphism in CYP2E1 Is Associated with the Development, Progression and Poor Outcome of Gastric Cancer.
Gene copy number change events at chromosome 20 and their association with recurrence in gastric cancer patients.
Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection.
Genetic polymorphisms of the cancer related gene and Helicobacter pylori infection in Japanese gastric cancer patients. An age and gender matched case-control study.
Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients.
GSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population.
Helicobacter pylori infection and genetic polymorphisms for cancer-related genes in gastric carcinogenesis.
Helicobacter pylori infection, but not genetic polymorphism of CYP2E1, is highly prevalent in gastric cancer patients younger than 40 years.
Hypomethylation of the XRE -1383 site is associated with the upregulation of CYP1A1 in gastric adenocarcinoma.
Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis.
Impact of CYP2D6 Polymorphisms on Postoperative Fentanyl Analgesia in Gastric Cancer Patients.
Interaction between cytochrome P-450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese.
Interaction models of CYP1A1, GSTM1 polymorphisms and tobacco smoking in intestinal gastric cancer.
Kimchi and soybean pastes are risk factors of gastric cancer.
LMP2A suppresses the role of AHR pathway through ERK signal pathway in EBV-associated gastric cancer.
Localization of Cytochrome P4502E1 Enzyme in Normal and Cancerous Gastric Mucosa and Association with Its Genetic Polymorphism in Unoperated and Remnant Stomach.
Meta-analysis of association studies of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese.
Meta-analysis of the association of CYP1A1 polymorphisms with gastric cancer susceptibility and interaction with tobacco smoking.
Modification effects of GSTM1, GSTT1 and CYP2E1 polymorphisms on associations between raw salted food and incomplete intestinal metaplasia in a high-risk area of stomach cancer.
Modulatory effect of naringenin on N-methyl-N'-nitro-N-nitrosoguanidine- and saturated sodium chloride-induced gastric carcinogenesis in male Wistar rats.
Polymorphism of CYPIA1 and GSTM1 genes associated with susceptibility of gastric cancer in Shandong Province of China.
Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.
Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 Genes are Independent Predictors of Gastric Cancer Risk in a Northern Jiangsu Population (China).
Quantitative assessment of the associations between CYP1A1 polymorphisms and gastric cancer risk.
Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1, and NAT2), drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer.
The association study between CYP24A1 gene polymorphisms and risk of liver, lung and gastric cancer in a Chinese population.
The effect of CYP1A1 and CYP1A2 polymorphisms on gastric cancer risk among different ethnicities: a systematic review and meta-analysis.
The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
[Activity of cytochrome P450 in the stomach, with special reference to postoperative survival rate of patients with gastric cancer treated by tegafur]
[Allelic variants of cytochrome P4501A1 (CYP1A1), glutathione S transferase M1 (GSTM1) polymorphisms and their association with smoking and alcohol consumption as gastric cancer susceptibility biomarkers]
[Meta-analysis on association between genetic polymorphisms of cytochrome P450 2E1 and susceptibility to Chinese gastric cancer].
[Polymorphisms in detoxification genes CYP1A1, CYP2E1, GSTT1 and GSTM1 in gastric cancer susceptibility]
[The distributive features of three kinds of metabolic genes polymorphisms in population of Han nationality in south area of China]
[The influence of CYP2A6 polymorphism on adjuvant S-1 chemotherapy outcomes in patients with curatively resected gastric cancer].
Stroke
16(R)-hydroxyeicosatetraenoic acid, a novel cytochrome P450 product of arachidonic acid, suppresses activation of human polymorphonuclear leukocyte and reduces intracranial pressure in a rabbit model of thromboembolic stroke.
20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease.
Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and ?-Subunit-Containing Gamma-Aminobutyric Acid A Receptors.
Association between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese.
Association of CYP1A1 Gene Polymorphism with Ischemic Stroke in South Indian Population.
AVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for the treatment of pseudobulbar affect and neuropathic pain.
Brain aromatase expression after experimental stroke: topography and time course.
Clinical Application of Genotype-guided Dosing of Warfarin in Patients with Acute Stroke.
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke.
CYP2C19 genotype and early ischemic lesion recurrence in stroke patients treated with clopidogrel.
CYP2C8 rs17110453 and EPHX2 rs751141 two-locus interaction increases susceptibility to ischemic stroke.
Cytochrome P450 1A1 (CYP1A1) T6325C polymorphism might modulate essential hypertension-associated stroke risk.
Cytochrome P450 in neurological disease.
Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls.
Does CYP2C19 polymorphisms affect neurological deterioration in stroke/TIA patients?: A systematic review and meta-analysis of prospective cohort studies.
Effect of ticagrelor with clopidogrel on high on-treatment platelet reactivity in acute stroke or transient ischemic attack (PRINCE) trial: Rationale and design.
Effects of Triflusal and Clopidogrel on the Secondary Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping.
Genetic Polymorphisms of ALOX5AP and CYP3A5 Increase Susceptibility to Ischemic Stroke and Are Associated with Atherothrombotic Events in Stroke Patients.
Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke.
Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain.
Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China.
Influence of cytochrome P450 polymorphisms on the antiplatelet effects of prasugrel in patients with non-cardioembolic stroke previously treated with clopidogrel.
Interaction between ALOX5AP and CYP3A5 gene variants significantly increases the risk for cerebral infarctions in Chinese.
Interaction between CYP1A1 T3801C and AHR G1661A polymorphisms according to smoking status on blood pressure in the Stanislas cohort.
Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke.
Investigating Real-World Clopidogrel Pharmacogenetics in Stroke Using a Bioresource Linked to Electronic Medical Records.
Metabolomic profiling of fatty acid biomarkers for intracerebral hemorrhage stroke.
Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack.
Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation.
Prevalence of combinatorial CYP2C9 and VKORC1 genotypes in Puerto Ricans: implications for warfarin management in Hispanics.
Prevalence of genetic polymorphisms of CYP2C9 and VKORC1 - implications for warfarin management and outcome in Croatian patients with acute stroke.
Protocol for the comparison of triflusal and clopidogrel in secondary prevention of stroke based on cytochrome P450 2C19 genotyping (MASETRO study): A multicenter, randomized, open-label, parallel-group trial.
Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke.
The influence of CYP1A1 and CYP1A2 polymorphisms on stroke risk in the Chinese population.
The role of cytochrome p-450 in salt-sensitive stroke in stroke-prone spontaneously hypertensive rats.
The secondary prevention of stroke according to cytochrome P450 2C19 genotype in patients with acute large-artery atherosclerosis stroke.
Universal versus genotype-guided use of direct oral anticoagulants in atrial fibrillation patients: a decision analysis.
Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE.
VKORC1 and CYP2C9 Genotype Variations in Relation to Warfarin Dosing in Korean Stroke Patients.
[Resistance to antiplatelet drugs in patients with cerebrovascular disorders].
Sturge-Weber Syndrome
Sturge-Weber Syndrome With Congenital Glaucoma and Cytochrome P450 (CYP1B1) Gene Mutations.
Stuttering
Sex steroid hormones and sex hormone binding globulin levels, CYP17 MSP AI (-34T:C) and CYP19 codon 39 (Trp:Arg) variants in children with developmental stuttering.
Subarachnoid Hemorrhage
20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis.
Evidence that 20-HETE contributes to the development of acute and delayed cerebral vasospasm.
Genetic markers in the EET metabolic pathway are associated with outcomes in patients with aneurysmal subarachnoid hemorrhage.
Pharmacogenomics of Cytochrome P450 of Nimodipine Metabolism After Aneurysmal Subarachnoid Hemorrhage.
Pharmacogenomics of Cytochrome P450 of Nimodipine Metabolism after Aneurysmal Subarachnoid Hemorrhage.
Protective role of p450 epoxyeicosanoids in subarachnoid hemorrhage.
Supranuclear Palsy, Progressive
A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism.
Syncope
CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System-Results From the ADRED Study.
Cytochrome P450-2D6 Genotype Definition May Improve Therapy for Paroxysmal Atrial Fibrillation A Case of Syncope Following "Pill-in-the-Pocket" Quinidine plus Propafenone.
Tachycardia
Effect of CYP2D6 genotype on flecainide pharmacokinetics in Japanese patients with supraventricular tachyarrhythmia.
Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism.
Propafenone for the prevention of atrial tachyarrhythmias after cardiac surgery: a randomized, double-blind placebo-controlled trial.
Tachycardia, Sinus
[Relationship of blood aryl hydrocarbon receptor mRNA and cytochrome P450 1A1 mRNA expression with corrected QT interval among residents exposed to arsenic via drinking water].
Tachycardia, Ventricular
CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system.
Tardive Dyskinesia
A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia.
Abnormal movements and tardive dyskinesia in smokers and nonsmokers with schizophrenia genotyped for cytochrome P450 2D6.
Antipsychotic drug-induced movement disorders in schizophrenics in relation to CYP2D6 genotype.
Antipsychotic-induced tardive dyskinesia and polymorphic variations in COMT, DRD2, CYP1A2 and MnSOD genes: a meta-analysis of pharmacogenetic interactions.
Association between CYP2D6 genotype and tardive dyskinesia in Korean schizophrenics.
Association of CYP2D6 and CYP1A2 gene polymorphism with tardive dyskinesia in Chinese schizophrenic patients.
Association of serotonin 2A receptor and lack of association of CYP1A2 gene polymorphism with tardive dyskinesia in a Turkish population.
Association of tardive dyskinesia with variation in CYP2D6: Is there a role for active metabolites?
Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects.
CYP2D6 genotype and tardive dyskinesia.
CYP2D6 polymorphism and tardive dyskinesia in schizophrenic patients.
CYP2D6 polymorphisms and the risk of tardive dyskinesia in schizophrenia: a meta-analysis.
CYP450 pharmacogenetic treatment strategies for antipsychotics: a review of the evidence.
Cytochrome P450 1A2 co-determines neuroleptic load and may diminish tardive dyskinesia by increased inducibility.
Cytochrome P450 2D6 genotyping and association with tardive dyskinesia in Chinese schizophrenic patients.
Genetic association analysis between CYP2D6*2 allele and tardive dyskinesia in schizophrenic patients
Genetic association analysis of functional polymorphisms in the cytochrome P450 1A2 (CYP1A2) gene with tardive dyskinesia in Japanese patients with schizophrenia.
Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: I. Association of CYP1A2 gene polymorphism.
Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms.
Genetic susceptibility to Tardive Dyskinesia in chronic schizophrenia subjects: V. Association of CYP1A2 1545 C>T polymorphism.
Lack of association between a functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene and tardive dyskinesia in schizophrenia.
Liver enzyme CYP2D6 gene and tardive dyskinesia.
Maintenance therapy with zuclopenthixol decanoate: associations between plasma concentrations, neurological side effects and CYP2D6 genotype.
Pharmacogenetics as a tool in the therapy of schizophrenia.
Pharmacogenomics in schizophrenia: the quest for individualized therapy.
Pharmacogenomics--can genetics help in the care of psychiatric patients?
Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness.
Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.
Review article: metoclopramide and tardive dyskinesia.
Smoking and tardive dyskinesia: lack of involvement of the CYP1A2 gene.
Tardive dyskinesia and debrisoquine 4-hydroxylase (CYP2D6) genotype in Japanese schizophrenics.
Tardive dyskinesia in CYP2D6 polymorphism in Chinese.
The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation.
Taste Disorders
Effects of aging on the human taste system.
Tauopathies
Cerebrotendinous xanthomatosis with the c.379C>T (p.R127W) mutation in the CYP27A1 gene associated with premature age-associated limbic tauopathy.
Telangiectasis
Hereditary Haemorrhagic Telangiectasia (HHT) Marked by ACVRL1C1120T Variant Displays Hypopigmented Naevi and Frequent Bleeding Episodes if CYP2C9 Co-Mutated: Clinical Notes & Rationale of Patient Registry.
Topical timolol for treatment of epistaxis in hereditary haemorrhagic telangiectasia associated with bradycardia: a look at CYP2D6 metabolising variants.
Teratoma
Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo.
Teratozoospermia
[Genetic genes associated with oligospermia, asthenospermia and teratospermia: Advances in studies].
Testicular Neoplasms
CYP1A1, CYP3A5 and CYP3A7 polymorphisms and testicular cancer susceptibility.
Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis.
Effect modification of endocrine disruptors and testicular germ cell tumour risk by hormone-metabolizing genes.
Feminizing Sertoli cell tumors in boys with Peutz-Jeghers syndrome.
Low CYP1A2 activity associated with testicular cancer.
[Testicular aromatase]
Thalassemia
Drug metabolizing enzyme CYP1A2 status in pediatric patients with hemoglobin E-beta thalassemia.
Modification of CYP2E1 and CYP3A4 activities in haemoglobin E-beta thalassemia patients.
Thecoma
Immunohistochemical studies of steroidogenic enzymes (aromatase, 17 alpha-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary.
Thiamine Deficiency
Effects of thiamine deficiency on hepatic cytochromes P450 and drug-metabolizing enzyme activities.
The influence of thiamine deficiency on porphyrin synthesis and porphyrin proteins.
thiopurine s-methyltransferase deficiency
Increasing relevance of pharmacogenetics of drug metabolism in clinical practice.
Thrombocytopenia
Drug interaction between itraconazole and bortezomib: exacerbation of peripheral neuropathy and thrombocytopenia induced by bortezomib.
Thromboembolism
Association between the CYP2C9 polymorphism and the drug metabolism phenotype.
Thrombophilia
Increased warfarin consumption and residual fibrin turnover in thrombotic patients with primary antiphospholipid syndrome.
Population study of thrombophilic markers and pharmacogenetic markers of warfarin prevalence in Bosnia and Herzegovina.
Standards and controls for genetic testing.
Thrombosis
Acute thrombosis of everolimus-eluting platinum chromium stent caused by impaired prasugrel metabolism due to cytochrome P450 enzyme 2B6*2 (C64T) polymorphism: a case report.
Adverse Interaction between Capecitabine and Warfarin Resulting in Altered Coagulation Parameters: A Review of the Literature Starting from a Case Report.
An evaluation of gene-gene interaction between the CYP2C9 and VKORC1 genotypes affecting the anticoagulant effect of phenprocoumon and acenocoumarol.
Antiplatelet Therapy After Implantation of Drug-Eluting Stents: Duration, Resistance, Alternatives, and Management of Surgical Patients.
Characterization of Patients With Angioscopically-Detected In-Stent Mural Thrombi.
Characterization of patients with angioscopically-detected in-stent mural thrombi.
Clopidogrel resistance: fact and fiction.
Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention.
Effect of polymorphisms in the cytochrome P450 CYP2C9 gene on warfarin anticoagulation.
Effects of genetic factors to stent thrombosis due to clopidogrel resistance after coronary stent placement.
Genetic variants associated with deep vein thrombosis: the F11 locus.
Genotyping of CYP2C9 and VKORC1 polymorphisms predicts south Indian patients with deep vein thrombosis as fast metabolizers of warfarin/acenocoumarin.
Global deregulation of ginseng products may be a safety hazard to warfarin takers: solid evidence of ginseng-warfarin interaction.
Impact of Cytochrome P450 2C19 Reduced-Function Polymorphism on Lesions and Clinical Outcome in Japanese Patients After Drug-eluting Stent Implantation.
Impact of cytochrome P450 2C19*2 polymorphism on intra-stent thrombus after drug-eluting stent implantation in Japanese patients receiving clopidogrel.
Impact of cytochrome P450 2C19*2 polymorphism on intra-stent thrombus assessed by follow-up optical coherence tomography in Chinese patients receiving clopidogrel.
Impact of genetic and clinical factors on warfarin therapy in patients early after heart valve replacement surgery.
Incidence of Device-Related Thrombosis in Watchman Patients Undergoing a Genotype-Guided Antithrombotic Strategy.
Polymorphisms of CYP2C9, VKORC1, MDR1, APOE and UGT1A1 genes and the therapeutic warfarin dose in Brazilian patients with thrombosis: a prospective cohort study.
Prevalence of CYP2C19 polymorphisms in the Lebanese population.
Prosthetic valve thrombosis - association of genetic polymorphisms of VKORC1, CYP2C9 and CYP4F2 genes.
Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis.
Relationship between cytochrome P450 2C19*2 polymorphism and stent thrombosis following percutaneous coronary intervention in Chinese patients receiving clopidogrel.
The Influence of VKORC1 Polymorphisms on Warfarin Doses in Thai Patients with Deep Vein Thrombosis.
Thrombotic genetic risk factors and warfarin pharmacogenetic variants in São Miguel's healthy population (Azores).
VKORC1 and CYP2C9 genetic polymorphisms in hepatic or portal vein thrombosis.
VKORC1 and CYP2C9 genotypes in Egyptian patients with warfarin resistance.
[FREQUENCY OF POLYMORPHISM OF VKORC1 AND CYP2C9 GENES IN TWO REGIONS OF GEORGIA].
Thyroid Cancer, Papillary
Cyp24a1 attenuation limits progression of BrafV600E-induced papillary thyroid cancer cells and sensitizes them to BRAFV600E inhibitor PLX4720.
Genetic polymorphism of CYP2D6 influences susceptibility to papillary thyroid cancer.
Increased CYP24A1 expression is associated with BRAF(V600E) mutation and advanced stages in papillary thyroid carcinoma.
Marked Increase in CYP24A1 Gene Expression in Human Papillary Thyroid Cancer.
Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.
Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer.
Thyroid Carcinoma, Anaplastic
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.
Thyroid Diseases
Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins.
Genetic Polymorphisms of Pesticide-Metabolizing Enzymes and Transporters in Agricultural Workers and Thyroid Hormone Levels.
Susceptibility to thyroid disorders in hepatitis C.
The biochemical and genetic diagnosis of lipid disorders.
Unusual genetic variants associated with hypercholesterolemia in Argentina.
[Association of polymorph variants of CYP1A2 and CYP1A1 genes with reproductive and thyroid diseases in female workers of petrochemical industry].
[DIO2, TPO, CYP1A1 AND CYP1A2 gene polymorphism in women with thyroid disease].
Thyroid Neoplasms
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.
Association between CYP2E1 polymorphisms and risk of differentiated thyroid carcinoma.
Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies.
Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer.
CYP24A1 depletion facilitates the antitumor effect of vitamin D3 on thyroid cancer cells.
CYP3A5*1 is an inhibitory factor for lung cancer in Taiwanese.
Gene Expression of CYP1A1 and its Possible Clinical Application in Thyroid Cancer Cases.
Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.
Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation.
Impaired Vitamin D activation and association with CYP24A1 haplotypes in differentiated thyroid carcinoma.
Impaired vitamin D activation and association with CYP24A1 haplotypes in differentiated thyroid carcinoma.
Increased CYP24A1 expression is associated with BRAF(V600E) mutation and advanced stages in papillary thyroid carcinoma.
Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.
Smoking and susceptibility to thyroid cancer: an inverse association with CYP1A1 allelic variants.
The Aryl Hydrocarbon Receptor Is Expressed in Thyroid Carcinoma and Appears to Mediate Epithelial-Mesenchymal-Transition.
Thyroid Nodule
Involvement of CYP1A1, GST, 72TP53 polymorphisms in the pathogenesis of thyroid nodules.
Thyroiditis
[DIO2, TPO, CYP1A1 AND CYP1A2 gene polymorphism in women with thyroid disease].
Thyroiditis, Autoimmune
[Association of polymorph variants of CYP1A2 and CYP1A1 genes with reproductive and thyroid diseases in female workers of petrochemical industry].
[DIO2, TPO, CYP1A1 AND CYP1A2 gene polymorphism in women with thyroid disease].
Thyrotoxicosis
MATERNAL GRAVES DISEASE AND ABNORMAL CYP2D6 GENOTYPE WITH FETAL HYPERTHYROIDISM.
Tinnitus
Acute and Chronic Molecular Signatures and Associated Symptoms of Blast Exposure in Military Breachers.
Tonsillitis
Opioid-induced respiratory depression in paediatrics: a review of case reports.
Torsades de Pointes
Alzheimer's disease: beware of interactions with cholinesterase inhibitors.
CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system.
Drug-drug interactions and clinical considerations with co-administration of antiretrovirals and psychotropic drugs.
Effects of H1 antihistamines on animal models of QTc prolongation.
First-Degree Atrioventricular Block with Tachycardia from Paliperidone and Mirtazapine Overdose.
Irritable Bowel Syndrome.
Major Cardiac-Psychiatric Drug-Drug Interactions: a Systematic Review of the Consistency of Drug Databases.
QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients.
Sex differences in arrhythmias.
Telithromycin: new preparation. A needless addition to the other macrolides.
The QT interval and torsade de pointes.
Torsade de pointes resulting from the addition of droperidol to an existing cytochrome P450 drug interaction.
Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.
[Long QT and torsade de pointes in a patient with acquired human immunodeficiency virus infection in multitherapy with drugs affecting cytochrome P450]
Toxemia
Cytochrome P450 metabolites of arachidonic acid in the control of renal function.
Toxic Optic Neuropathy
Cytotoxic metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, produces cataract in DBA2 mice.
Histocytological study on the possible mechanism of acetaminophen cataractogenesis in mouse eye.
Trauma, Nervous System
Three patients with probable aerotoxic syndrome.
Tremor
Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor.
Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin.
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9.
Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice.
Trigeminal Neuralgia
Evaluation of the Pharmacokinetic Interaction Between the Voltage- and Use-Dependent Nav1.7 Channel Blocker Vixotrigine and Carbamazepine in Healthy Volunteers.
Triple Negative Breast Neoplasms
Anti-migration and anti-invasion effects of 2-hydroxy-6-tridecylbenzoic acid is associated with the enhancement of CYP1B1 expression through activating the AMPK signaling pathway in triple-negative breast cancer cells.
Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy.
Single-nucleotide polymorphisms and mRNA expression of CYP1B1 influence treatment response in triple negative breast cancer patients undergoing chemotherapy.
Trismus
Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with CYP2C8*3 and CYP2C9.
Tuberculosis
A comparison of steroid and lipid binding cytochrome P450s from Mycobacterium marinum and Mycobacterium tuberculosis.
A highly conserved mycobacterial cholesterol catabolic pathway.
A novel IS element, ISMpa1, in Mycobacterium avium subsp. paratuberculosis.
Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients.
Association of genetic polymorphisms of CYP2E1, NAT2, GST and SLCO1B1 with the risk of anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis.
Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450.
Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.
Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis.
Biodiversity of cytochrome P450 redox systems.
Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.
Biotransformation and bioactivation reactions - 2015 literature highlights.
Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis.
Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.
Cholesterol Analogs with Degradation-resistant Alkyl Side Chains Are Effective Mycobacterium tuberculosis Growth Inhibitors.
Clinically significant drug interactions with antituberculosis agents.
Cloning of the Recombinant Cytochrome P450 Cyp141 Protein of Mycobacterium tuberculosis as a Diagnostic Target and Vaccine Candidate.
Comparative assessment of metabolic enzyme levels in macrophage populations of the F344 rat.
Comparative study of the effects of anti-tuberculosis drugs and antiretroviral drugs on CYP3A4 and P-glycoprotein.
Computational finding of potential inhibitor for Cytochrome P450 Mono-oxygenases Enzyme of Mycobacterium tuberculosis.
Concerning P450 evolution: Structural Analyses Support Bacterial Origin of Sterol 14?-Demethylases.
Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 from Mycobacterium tuberculosis proceeds through a catalytic shunt pathway.
Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors.
Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode.
Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis.
CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen.
CYP2B6 18492T->C Polymorphism Compromises Efavirenz Concentration in Coinfected HIV and Tuberculosis Patients Carrying CYP2B6 Haplotype *1/*1.
CYP2C8 and CYP2E1 genetic variants increase risk of tuberculosis in northwest Chinese Han population.
CYP2E1 polymorphism, acetylator profiles and drug-induced liver injury incidence of Indonesian tuberculosis patients.
CYP2E1, GSTM1, and GSTT1 genetic polymorphisms and their associations with susceptibility to antituberculosis drug-induced liver injury in Thai tuberculosis patients.
CYP51-like gene of Mycobacterium tuberculosis actually encodes a P450 similar to eukaryotic CYP51.
cyp51A-based mechanism of azole resistance in Aspergillus fumigatus: Illustration by a new 3D Structural Model of Aspergillus fumigatus CYP51A protein.
Cytochrome CYP141: a new target for direct detection of Mycobacterium tuberculosis from clinical specimens.
Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection.
Cytochromes P450: novel drug targets in the war against multidrug-resistant Mycobacterium tuberculosis.
Delamanid for the treatment of pulmonary multidrug-resistant tuberculosis.
Deletion of cyp125 Confers Increased Sensitivity to Azoles in Mycobacterium tuberculosis.
Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors.
Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics.
Distribution of allelic and genotypic frequencies of NAT2 and CYP2E1 variants in Moroccan population.
Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily.
Effect of Rifampicin and CYP2B6 Genotype on Long-Term Efavirenz Autoinduction and Plasma Exposure in HIV Patients With or Without Tuberculosis.
Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients.
Electrochemistry of cytochromes p450: analysis of current-voltage characteristics of electrodes with immobilized cytochromes p450 for the screening of substrates and inhibitors.
Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium.
Establishing Dosing Recommendations for Efavirenz in HIV/TB-Coinfected Children Younger Than 3 Years.
Evaluation of cellular immunogenicity of recombinant cytochrome p450 cyp141 protein of Mycobacterium tuberculosis in human and mouse model.
Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to Mycobacterium tuberculosis.
Evaluation of the drug interaction between rifabutin and efavirenz in patients with HIV infection and tuberculosis.
Expression and characterization of Mycobacterium tuberculosis CYP144: Common themes and lessons learned in the M. tuberculosis P450 enzyme family.
Expression and Purification of the Recombinant Cytochrome P450 CYP141 Protein of Mycobacterium Tuberculosis as a Diagnostic Tool and Vaccine Production.
Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis.
Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1.
Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?
Functional polymorphisms in CYP2C19 & CYP3A5 genes associated with decreased susceptibility for paediatric tuberculosis.
Genetic and Mass Spectrometric Tools for Elucidating the Physiological Function(s) of Cytochrome P450 Enzymes from Mycobacterium tuberculosis.
Genetic polymorphisms of cytochrome P450 and glutathione S-transferase associated with antituberculosis drug-induced hepatotoxicity in Chinese tuberculosis patients.
Genetic variation of ABCB1 (rs1128503, rs1045642) and CYP2E1 rs3813867 with the duration of tuberculosis therapy: a pilot study among tuberculosis patients in Indonesia.
Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.
Identification of small-molecule scaffolds for p450 inhibitors.
Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.
Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines.
Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA.
Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners.
MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51.
Multiple drug binding modes in Mycobacterium tuberculosis CYP51B1.
Mycobacterial cytochrome P450 125 (Cyp125) catalyzes the terminal hydroxylation of C27-steroids.
Mycobacterium tuberculosis CYP130: crystal structure, biophysical characterization, and interactions with antifungal azole drugs.
Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets.
Mycobacterium tuberculosis Rv1395 is a class III transcriptional regulator of the AraC family involved in cytochrome P450 regulation.
N-acetyltransferase and cytochrome P450 2E1 gene polymorphisms and susceptibility to antituberculosis drug hepatotoxicity in an Indian population.
NAT2 and CYP2E1 polymorphisms associated with antituberculosis drug-induced hepatotoxicity in Chinese patients.
New Application of 1,2,4-Triazole Derivatives as Antitubercular Agents. Structure, In Vitro Screening and Docking Studies.
Optimising plasma levels of clozapine during metabolic interactions: a review and case report with adjunct rifampicin treatment.
Pharmacokinetics of rifabutin during atazanavir/ritonavir co-administration in HIV-infected TB patients in India.
Photosystem I from plants as a bacterial cytochrome P450 surrogate electron donor: terminal hydroxylation of branched hydrocarbon chains
Photosystem I from plants as a bacterial cytochrome P450 surrogate electron donor: terminal hydroxylation of branched hydrocarbon chains.
Polymorphisms in CYP2E1, GSTM1 and GSTT1 and anti-tuberculosis drug-induced hepatotoxicity.
Polymorphisms of NAT2, CYP2E1, GST, and HLA related to drug-induced liver injury in indonesian tuberculosis patients.
Population Pharmacokinetics and Pharmacogenetics of Ethambutol in Adult Patients Coinfected with Tuberculosis and HIV.
Potential drug targets in the Mycobacterium tuberculosis cytochrome P450 system.
Probing Ligand Exchange in the P450 Enzyme CYP121 from Mycobacterium tuberculosis: Dynamic Equilibrium of the Distal Heme Ligand as a Function of pH and Temperature.
QM/MM study of the C-C coupling reaction mechanism of CYP121, an essential Cytochrome p450 of Mycobacterium tuberculosis.
Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.
Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide.
Relationship between CYP2E1 polymorphism and increase of ALT activity during therapy of patients with pulmonary tuberculosis.
Reverse type I inhibitor of Mycobacteriumtuberculosis CYP125A1.
Rifabutin for treating tuberculosis in solid organ transplant recipients: a retrospective observational study and literature review.
Risk factors of isoniazid-induced hepatotoxicity in Tunisian tuberculosis patients.
Safety, Tolerability, and Pharmacokinetic Interactions of the Antituberculous Agent TMC207 (Bedaquiline) With Efavirenz in Healthy Volunteers: AIDS Clinical Trials Group Study A5267.
Selective ?-1 oxidation of fatty acids by CYP147G1 from Mycobacterium marinum.
Serum Rifampicin Levels in Patients with Tuberculosis : Effect of P-Glycoprotein and CYP3A4 Blockers on its Absorption.
Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis.
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: Evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
Structural basis of human CYP51 inhibition by antifungal azoles.
Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis.
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis.
Structure, function and drug targeting in Mycobacterium tuberculosis cytochrome P450 systems.
Substrate analog studies of the ?-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1.
Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121: insights from biochemical studies and crystal structures.
Substrate-Assisted Hydroxylation and O-Demethylation in the Peroxidase-like Cytochrome P450 Enzyme CYP121.
The crystal structure of FdxA, a 7Fe ferredoxin from Mycobacterium smegmatis.
The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2).
The effect of isoniazid containing regimen on CYP2E1 during antituberculosis therapy.
The Mycobacterium tuberculosis cytochrome P450 system.
The Mycobacterium tuberculosis cytochromes P450: physiology, biochemistry & molecular intervention.
The preponderance of P450s in the Mycobacterium tuberculosis genome.
The role of genetic polymorphisms in cytochrome P450 and effects of tuberculosis co-treatment on the predictive value of CYP2B6 SNPs and on efavirenz plasma levels in adult HIV patients.
The structure of Mycobacterium tuberculosis CYP125: Molecular basis for cholesterol binding in a P450 needed for host infection.
Therapeutic drug monitoring and pharmacogenetic study of HIV-infected ethnic chinese receiving efavirenz-containing antiretroviral therapy with or without rifampicin-based anti-tuberculous therapy.
Toxicity of HIV protease inhibitors: clinical considerations.
[Genetic heterogeneity of cytochrome CYP51 in clinical strains of Mycobacterium tuberculosis]
[Opportunistic diseases--current aspects in 2004]
[Overactive bladder in a complicated patient: which drug to choose?]
Tuberculosis, Meningeal
Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G?T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis.
Tuberculosis, Pulmonary
Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis.
Relationship between CYP2E1 polymorphism and increase of ALT activity during therapy of patients with pulmonary tuberculosis.
[Insertional polymorphism of the CYP2E1 gene in infiltrative pulmonary tuberculosis in populations of Bashkortostan Republic]
Tumor Lysis Syndrome
Venetoclax plus cytochrome P450 inhibitors without ramp-up strategy led to low risk of tumor lysis syndrome in acute myeloid leukemia.
Turner Syndrome
Adrenal-cortex autoantibodies and steroid-producing cells autoantibodies in patients with Addison's disease: comparison of immunofluorescence and immunoprecipitation assays.
unspecific monooxygenase deficiency
A pilot study on risperidone metabolism: the role of cytochromes P450 2D6 and 3A.
A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom).
A Young Woman with Recurrent Gestational Hypercalcemia and Acute Pancreatitis Due to CYP24A1 Deficiency.
Activity Levels of Tamoxifen Metabolites at the Estrogen Receptor and the Impact of Genetic Polymorphisms of Phase I and II Enzymes on Their Concentration Levels in Plasma.
Acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA) in Sprague-Dawley and Dark Agouti rats.
Adverse drug reactions following nonresponse in a depressed patient with CYP2D6 deficiency and low CYP 3A4/5 activity.
Characterization of a Novel CYP1A2 Knockout Rat Model Constructed by CRISPR/Cas9.
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review.
Clinical importance of genetic polymorphism of drug oxidation.
Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.
CYP1B1 deficiency ameliorates obesity and glucose intolerance induced by high fat diet in adult C57BL/6J mice.
CYP1B1 deiciency ameliorates learning and memory deficits caused by high fat diet in mice.
CYP24A1 deficiency causing persistent hypercalciuria in a stone former.
CYP24A1 Mutations in a Cohort of Hypercalcemic Patients: Evidence for a Recessive Trait.
CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24.
CYP2D6 deficiency, a factor in ecstasy related deaths?
CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects.
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
Cytochrome P450 1B1 and Primary Congenital Glaucoma.
Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum.
Cytochrome P450 2D6 deficiency and its clinical relevance in a patient treated with risperidone.
Cytochrome P450 2E1 (CYP2E1) positively regulates lipid catabolism and induces browning in 3T3-L1 white adipocytes.
Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene.
Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.
Delayed resolution of amitriptyline toxicity secondary to CYP2D6 deficiency.
Dextromethorphan poisoning in an adolescent with genetic cytochrome P450 CYP2D6 deficiency.
Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Distinct Binding of Cholesterol and 5beta-Cholestane-3alpha,7alpha,12alpha-triol to Cytochrome P450 27A1: Evidence from Modeling and Site-Directed Mutagenesis Studies.
Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo.
Effect of CYP1A2 deficiency on heterocyclic amine DNA adduct levels in mice.
Effect of CYP2D1 inhibition on the behavioural effects of d-amphetamine.
Elucidation of the effects of the CYP1A2 deficiency polymorphism in the metabolism of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1h)-one (YM-64227), a phosphodiesterase type 4 inhibitor, and its metabolites in dogs.
Evidence for a role of sterol 27-hydroxylase in glucocorticoid metabolism in vivo.
Female pseudohermaphroditism associated with a novel homozygous G-to-A (V370-to-M) substitution in the P-450 aromatase gene.
Follicular fluid steroid and epidermal growth factor content, and in vitro estrogen release by granulosa-luteal cells from patients with polycystic ovaries in an IVF/ET program.
Frequent Atrial Fibrillation in CYP2D6 Deficiency.
Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County.
Genetic polymorphism of cytochrome P450s in beagles: possible influence of CYP1A2 deficiency on toxicological evaluations.
Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis.
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
High-dose venlafaxine treatment in a depressed patient with a genetic CYP2D6 deficiency.
Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA.
Influence of CYP2D6 genotype and medication on the sparteine metabolic ratio of psychiatric patients.
Inhibition of CYP2D6 by quinidine and its effects on the metabolism of cilostazol.
Intractable hypercalcaemia during pregnancy and the postpartum secondary to pathogenic variants in CYP24A1.
Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells.
Misdiagnosis of CTX due to propofol: The interference of total intravenous propofol anaesthesia with bile acid profiling.
Neuroleptic malignant syndrome in an adolescent with CYP2D6 deficiency.
Pilot study of the cytochrome P450-2D6 genotype in a psychiatric state hospital.
Short communication. The effects of drinking and smoking on the CYP2D6 metabolic capacity.
Targeted Next-Generation Sequencing in Diagnostic Approach to Monogenic Cholestatic Liver Disorders-Single-Center Experience.
The canine CYP1A2 deficiency polymorphism dramatically affects the pharmacokinetics of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-D]-pyrimidine-2-(1H)-one (YM-64227), a phosphodiesterase type 4 inhibitor.
The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats.
Toxicokinetic Interaction between Hepatic Disposition and Pulmonary Bioactivation of Inhaled Naphthalene Studied Using Cyp2abfgs-Null and CYP2A13/2F1-Humanized Mice with Deficient Hepatic Cytochrome P450 Activity.
Warfarin therapy is feasible in CYP2C9*3 homozygous patients.
Uremia
Effect of hemodialysis on hepatic cytochrome P450 functional expression.
Expression of hepatic microsomal cytochrome P450s as altered by uremia.
Hemodialysis acutely improves hepatic CYP3A4 metabolic activity.
Nitric oxide- and EDHF-mediated arteriolar tone in uremia is unaffected by selective inhibition of vascular cytochrome P450 2C9.
Reduced hepatic synthesis of calcidiol in uremia.
Urinary Bladder Neoplasms
Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.
Aryl hydrocarbon hydroxylase inducibility is not altered in bladder cancer patients or their progeny.
Association between polymorphisms in the biometabolism genes CYP1A1, GSTM1, GSTT1 and GSTP1 in bladder cancer.
Association between the CYP1A2 rs762551 Polymorphism and Bladder Cancer Susceptibility: a Meta-Analysis Based on Case-Control Studies.
Association of CYP2E1 gene polymorphisms with bladder cancer risk: A systematic review and meta-analysis.
Association of genotypes of carcinogen-metabolizing enzymes and smoking status with bladder cancer in a Japanese population.
Association of low CYP3A activity with p53 mutation and CYP2D6 activity with Rb mutation in human bladder cancer.
Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China.
Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer.
Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.
Carotenoids/vitamin C and smoking-related bladder cancer.
Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk.
Comparison of CYP1A2 and NAT2 phenotypes between black and white smokers.
Correlation of polymorphic expression of CYP2D6 mRNA in bladder mucosa and tumor tissue to in vivo debrisoquine hydroxylase activity.
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms and bladder cancer risk in a Turkish population.
CYP1A1 expression and organochlorine pesticides level in the etiology of bladder cancer in North Indian population.
CYP1A2 activity as a risk factor for bladder cancer.
CYP1A2 polymorphisms, occupational and environmental exposures and risk of bladder cancer.
CYP1A2, CYP2D6, GSTM1, GSTP1, and GSTT1 gene polymorphisms in patients with bladder cancer in a Turkish population.
CYP1B1 gene polymorphisms correlate with an increased risk of urinary bladder cancer in India.
CYP24A1 rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System.
CYP27A1 inhibits bladder cancer cells proliferation by regulating cholesterol homeostasis.
CYP2E1 and NQO1 genotypes and bladder cancer risk in a Lebanese population.
CYP2E1 and NQO1 genotypes, smoking and bladder cancer.
Cytochrome P450 isoenzyme mRNA expression pattern in human urinary bladder malignancies and normal urothelium.
Cytochrome P4501A2 phenotype and bladder cancer risk: The shanghai bladder cancer study.
Debrisoquine hydroxylase (CYP2D6) and prostate cancer.
Detection of CYP1A1 and GSTP1 gene polymorphisms in bladder cancer patients in a Turkish population using a polymerase chain reaction-restriction fragment length polymorphism method.
Development Of A Three-Gene Prognostic Signature For Hepatitis B Virus Associated Hepatocellular Carcinoma Based On Integrated Transcriptomic Analysis.
Expression of xenobiotic metabolizing enzymes in tumours of the urinary bladder.
Expression profile of CYP1A1 and CYP1B1 enzymes in colon and bladder tumors.
Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population.
Functional RsaI/PstI polymorphism in cytochrome P450 2E1 contributes to bladder cancer susceptibility: evidence from a meta-analysis.
Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer.
Genetic polymorphism of drug metabolizing enzymes (CYP2E1, GSTP1) and susceptibility to bladder cancer in North India.
Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients.
Genetic Polymorphisms in CYP1A1, CYP1B1, COMT, GSTP1 and NAT2 Genes and Association with Bladder Cancer Risk in a French Cohort.
Genetic polymorphisms in the CYP1A1 and CYP1B1 genes and susceptibility to bladder cancer: a meta-analysis.
Genetic Polymorphisms of CYP2A6 in a Case-Control Study on Bladder Cancer in Japanese Smokers.
Genetic polymorphisms of CYP2D6, GSTM1, and GSTT1 genes and bladder cancer risk in North India.
Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India.
Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers.
Genetic variants of the cytochrome P450 and glutathione S-transferase associated with risk of bladder cancer in a south-eastern Chinese population.
Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.
GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population.
Human cytochrome P4501A2.
Is environmental carcinogenesis modulated by host polymorphism?
Lack of association between CYP1A1 polymorphisms and risk of bladder cancer: a meta-analysis.
Metabolomic profiling reveals potential markers and bioprocesses altered in bladder cancer progression.
Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2.
Polymorphic CYP genes and disease predisposition--what have the studies shown so far?
Polymorphism and smoking in bladder carcinogenesis.
Polymorphisms in GSTT1, GSTZ1, and CYP2E1, Disinfection Byproducts, and Risk of Bladder Cancer in Spain.
Polymorphisms in xenobiotic conjugation and disease predisposition.
Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population.
Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones.
Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers.
Relationships Between CYP1A1 Genetic Polymorphisms and Bladder Cancer Risk: A Meta-Analysis.
Retraction Note to: Genetic polymorphisms in the CYP1A1 and CYP1B1 genes and susceptibility to bladder cancer: a meta-analysis.
Role of CYP1B1 gene polymorphisms in bladder cancer susceptibility.
Study design and genetic susceptibility factors in the risk assessment of chemical carcinogens.
The CYP1B1 Leu432Val polymorphism and risk of urinary system cancers.
The CYP2D6 extensive metabolizer genotype is associated with increased risk for bladder cancer.
The effect of CYP1A1 and GSTM1 gene polymorphisms in bladder cancer development in a Turkish population.
The relationship between polymorphisms of xenobiotic metabolizing enzymes and susceptibility to cancer.
Use of analgesics and nonsteroidal anti-inflammatory drugs, genetic predisposition, and bladder cancer risk in Spain.
Variation in enzymes of arylamine procarcinogen biotransformation among bladder cancer patients and control subjects.
[Steroid and xenobiotic receptor (SXR), multidrug resistance gene (MDR1) and GSTs, SULTs and CYP polymorphism expression in invasive bladder cancer, analysis of their expression and correlation with other prognostic factors]
Urinary Bladder, Overactive
Assessment of inhibitory effects on major human cytochrome P450 enzymes by spasmolytics used in the treatment of overactive bladder syndrome.
Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective ?(3)-adrenoceptor agonist.
In vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective ?3-adrenoceptor agonist.
Overactive Bladder Prescribing Considerations: The Role of Polypharmacy, Anticholinergic Burden, and CYP2D6 Drug?Drug Interactions.
Urinary Calculi
Ultra-rare renal diseases diagnosed with whole-exome sequencing: Utility in diagnosis and management.
Urinary Incontinence
Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers.
Genetic susceptibility to urinary incontinence: implication of polymorphisms of androgen and oestrogen pathways.
Urinary Incontinence, Urge
Inhibitory effects of trospium chloride on cytochrome P450 enzymes in human liver microsomes.
Urinary Tract Infections
Cytochrome P450 (CYP2D6) Genotype is Associated with Elevated Systolic Blood Pressure in Preterm Infants after Discharge from the Neonatal Intensive Care Unit.
Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study.
Urogenital Neoplasms
Pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine, and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers.
Urolithiasis
Three Sisters With Heterozygous Gene Variants of CYP24A1: Maternal Hypercalcemia, New-Onset Hypertension, and Neonatal Hypoglycemia.
Urologic Neoplasms
Cytochrome P450 2E1 RsaI/PstI polymorphism is associated with urologic cancer risk: evidence from a meta-analysis.
Urticaria
Disruption of quercetin metabolism by fungicide affects energy production in honey bees (Apis mellifera).
Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria.
Uterine Cervical Neoplasms
Allelic variations in CYP2D6 gene and susceptibility to cervical cancer.
Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer.
Anti-estrogenic activities of indole-3-carbinol in cervical cells: implication for prevention of cervical cancer.
Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) with cervical cancer in a North Indian population.
Cervical cancer and CYP2E1 polymorphisms: implications for molecular epidemiology.
CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.
CYP1A1 gene polymorphism as a risk factor for cervical intraepithelial neoplasia and invasive cervical cancer.
CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis.
CYP1A1 Ile462Val Polymorphism as a Risk Factor in Cervical Cancer Development in the Polish Population.
CYP1A1 MspI Polymorphism and Cervical Carcinoma Risk in the Multi-Ethnic Population of Malaysia: a Case-Control Study.
CYP1B1 C4326G polymorphism and susceptibility to cervical cancer in Chinese Han women.
CYP3A5*1 is an inhibitory factor for lung cancer in Taiwanese.
Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and cervical cancer risk: a meta-analysis.
Cytochrome P450 1A1 gene polymorphisms and cervical cancer risk: A systematic review and meta-analysis.
Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer.
Genetic Polymorphisms of the Human Cytochrome P450 1A1 (CYP1A1) and Cervical Cancer Susceptibility among Northeast Thai Women.
Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection.
HLA genes and other candidate genes involved in susceptibility for (pre)neoplastic cervical disease.
Meta-Analysis of Polymorphic Variants Conferring Genetic Risk to Cervical Cancer in Indian Women Supports CYP1A1 as an Important Associated Locus
Polymorphism of CYP1A1 gene variants rs4646903 and rs1048943 relation to the incidence of cervical cancer in Chhattisgarh.
Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India.
Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium.
Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking.
Significant association between CYP1A1 T3801C polymorphism and cervical neoplasia risk: a systematic review and meta-analysis.
The Association of CYP1A1 Gene With Cervical Cancer and Additional SNP-SNP Interaction in Chinese Women.
The risk of developing cervical cancer in Mexican women is associated to CYP1A1 MspI polymorphism.
Vaccinia
Catalytic properties of the human cytochrome P450 2E1 produced by cDNA expression in mammalian cells.
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver.
Characterization of the human cytochrome P450 isozymes responsible for styrene metabolism.
Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1.
Chlorzoxazone metabolism by winter flounder liver microsomes: evidence for existence of a CYP2E1-like isoform in teleosts.
Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system.
Cytochrome P450 2A1, 2E1, and 2C9 cDNA-expression by insect cells and partial purification using hydrophobic chromatography.
Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expressed, microsomal, and purified CYP1A1 and CYP1A2.
Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s.
Expression of mammalian cytochrome P450 using vaccinia virus.
Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.
Human cDNA-expressed cytochrome P450 IA2: mutagen activation and substrate specificity.
Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily.
Human liver oxidative metabolism of O6-benzylguanine.
Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype.
Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism.
Metabolic activation of the pneumotoxin, 3-methylindole, by vaccinia-expressed cytochrome P450s.
Molecular biology of human xenobiotic-metabolizing cytochromes P450: role of vaccinia virus cDNA expression in evaluating catalytic function.
Mutagen activation by cDNA-expressed P(1)450, P(3)450, and P450a.
Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline by complementary DNA-expressed human liver P-450.
Oxidative metabolism of bunitrolol by complementary DNA-expressed human cytochrome P450 isozymes in a human hepatoma cell line (Hep G2) using recombinant vaccinia virus.
Role of cytochrome P450 IA2 in acetanilide 4-hydroxylation as determined with cDNA expression and monoclonal antibodies.
Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.
Selective suppression of the catalytic activity of cDNA-expressed cytochrome P4502B1 toward polycyclic hydrocarbons in the microsomal membrane: modification of this effect by specific amino acid substitutions.
Specificity of cDNA-expressed human and rodent cytochrome P450s in the oxidative metabolism of the potent carcinogen 7,12-dimethylbenz[a]anthracene.
Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes.
Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s.
Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450.
The metabolism of 1-nitropyrene by human cytochromes P450.
Varicose Veins
Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis.
Influence of CYP2D6 and ?2-adrenergic receptor gene polymorphisms on the hemodynamic response to propranolol in Chinese Han patients with cirrhosis.
[Cytochromes P450, vascular tone varicosis]
Vascular Calcification
CYP24A1 and KL polymorphisms are associated with the extent of vascular calcification but do not improve prediction of cardiovascular events.
Vascular Diseases
Common polymorphisms in CYP2C9, subclinical atherosclerosis and risk of ischemic vascular disease in 52,000 individuals.
Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease.
Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes.
Role of the Aryl Hydrocarbon Receptor/ARNT/Cytochrome P450 System in Pulmonary Vascular Diseases.
Vascular Malformations
2,3,7,8-Tetrachlorodibenzo-p-dioxin exposure disrupts development of the visceral and ocular vasculature.
Vascular System Injuries
Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism?
Vasculitis
Cyclophosphamide treatment-induced leukopenia rates in ANCA-associated vasculitis are influenced by variant CYP450 2C9 genotypes.
The pharmacogenomic association of Fc? receptors and cytochrome p450 enzymes and response to treatment with rituximab or cyclophosphamide in Anti-Neutrophil Cytoplasmic Antibody-Associated vasculitis.
Use of Enantiomeric Bupropion and Hydroxybupropion to Assess CYP2B6 Activity in Glomerular Kidney Diseases.
Venous Thromboembolism
A regression model to predict warfarin dose from clinical variables and polymorphisms in CYP2C9, CYP4F2, and VKORC1: Derivation in a sample with predominantly a history of venous thromboembolism.
CYP1A1, smoking and venous thromboembolism.
Efficiency and effectiveness of the use of an acenocoumarol pharmacogenetic dosing algorithm versus usual care in patients with venous thromboembolic disease initiating oral anticoagulation: study protocol for a randomized controlled trial.
Prediction of stable acenocoumarol dose by a pharmacogenetic algorithm.
Synergism between oral estrogen therapy and cytochrome P450 3A5*1 allele on the risk of venous thromboembolism among postmenopausal women.
VKORC1 and CYP2C9 polymorphisms are associated with warfarin dose requirements in Turkish patients.
Venous Thrombosis
CYP2C9 polymorphism studies in the Saudi population.
Effect of polymorphisms in the cytochrome P450 CYP2C9 gene on warfarin anticoagulation.
Genetic variants associated with deep vein thrombosis: the F11 locus.
Genotyping of CYP2C9 and VKORC1 polymorphisms predicts south Indian patients with deep vein thrombosis as fast metabolizers of warfarin/acenocoumarin.
Influence of CYP2C9 polymorphism and phenytoin co-administration on acenocoumarol dose in patients with cerebral venous thrombosis.
Regulation of the f11, klkb1, cyp4v3 gene cluster in livers of metabolically challenged mice.
The Influence of VKORC1 Polymorphisms on Warfarin Doses in Thai Patients with Deep Vein Thrombosis.
VKORC1 and CYP2C9 genotypes in Egyptian patients with warfarin resistance.
Vesicular Stomatitis
Molecular basis for the transport of cytochrome P450 2E1 to the plasma membrane.
Viremia
Ethanol and hepatocellular injury.
Virus Diseases
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection.
Changes of antipyrine pharmacokinetics during influenza and after administration of interferon-alpha and -beta.
CYP24A1 genetic variants in the vitamin D metabolic pathway are involved in the outcomes of hepatitis C virus infection among high-risk Chinese population.
Cytochrome P450 2A6 meets P450 2D6: an enigma of viral infections and autoimmunity.
Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection.
Cytochrome P450 down-regulation by serum from humans with a viral infection and from rabbits with an inflammatory reaction.
Cytochrome P450 inactivation by serum from humans with a viral infection and serum from rabbits with a turpentine-induced inflammation: the role of cytokines.
Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients.
Distribution of Polymorphisms in Cytochrome P450 2B6, Histocompatibility Complex P5, Chemokine Coreceptor 5, and Interleukin 28B Genes in Inhabitants from the Central Area of Argentina.
Down-regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: implication of mediators in human and animal serum and in the liver.
Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.
Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice.
Effect of low-dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers.
Enhanced bioactivity of silybin B methylation products.
Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China.
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Impact of CYP2R1, CYP27A1 and CYP27B1 genetic polymorphisms controlling vitamin D metabolism on susceptibility to hepatitis C virus infection in a high-risk Chinese population.
Inflammation-induced phenoconversion of polymorphic drug metabolizing enzymes: hypothesis with implications for personalized medicine.
Influence of Cytochrome P450 3A5 Polymorphisms on Viral Infection Incidence in Kidney Transplant Patients Treated With Tacrolimus.
Interleukin-1beta, interleukin-6, tumour necrosis factor-alpha and interferon-gamma released by a viral infection and an aseptic inflammation reduce CYP1A1, 1A2 and 3A6 expression in rabbit hepatocytes.
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection.
Modulatory effect of hyperthermia on hepatic microsomal cytochrome P450 in mice.
RAPID DEVELOPMENT OF IATROGENIC CUSHING SYNDROME IN A PATIENT ON RITONAVIR: THE ADVERSE METABOLIC CONSEQUENCE OF TOPICAL STEROID USE.
Role of Cytochrome P450 2B6 Pharmacogenomics in Determining Efavirenz-Mediated Central Nervous System Toxicity, Treatment Outcomes, and Dosage Adjustments in Patients with Human Immunodeficiency Virus Infection.
Role of reactive oxygen intermediates in the decrease of hepatic cytochrome P450 activity by serum of humans and rabbits with an acute inflammatory reaction.
Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.
Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine.
Signal transduction pathways implicated in the decrease in CYP1A1, 1A2 and 3A6 activity produced by serum from rabbits and humans with an inflammatory reaction.
Statin-associated myopathy.
[HEV capsid protein interacts with CYP 2A6 and decreases its coumarin 7-hydroxylation activity]
[Long QT and torsade de pointes in a patient with acquired human immunodeficiency virus infection in multitherapy with drugs affecting cytochrome P450]
[Perspective technologies for drug design]
[Progress in the study of heterogeneous nuclear ribonucleoprotein and its relation with diseases]
Vitamin A Deficiency
Cyp1b1 deletion and retinol deficiency coordinately suppress mouse liver lipogenic genes and hepcidin expression during post-natal development.
Pretranslational down regulation of cytochrome P450 2C11 in vitamin A-deficient male rat liver: prevention by dietary inclusion of retinoic acid.
Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status.
Restoration of cytochrome P450 2C11 in vitamin A-deficient rat liver by exogenous androgen.
Role of signalling systems in the effects of dietary factors on the expression of mammalian CYPs.
Suppression of the constitutive microsomal cytochrome P450 2C11 in male rat liver during dietary vitamin A deficiency.
The differential effects of chemical carcinogens on vitamin A status and on microsomal drug metabolism in normal and vitamin A-deficient rats.
Vitamin A levels in regenerating rat liver. Effects on microsomal drug metabolism.
Vitamin B 6 Deficiency
Pyridoxine deficiency modulates benzene inhalation-induced hematotoxicity associated with hepatic CYP2E1 activity in B6C3F1 mice.
The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1 mice.
Vitamin D Deficiency
A theoretical insight to understand the molecular mechanism of dual target ligand CTA-018 in the chronic kidney disease pathogenesis.
Assessing vitamin D related genetic variants, status, and influence factors in pregnant women in Eastern and Central China.
Associations of CYP24A1 Copy Number Variation with Vitamin D Deficiency and Insulin Secretion.
Characterization of an animal model of pregnancy-induced vitamin D deficiency due to metabolic gene dysregulation.
Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D(3) through CYP3A4 induction in vitro and in vivo: Implications for drug-induced osteomalacia.
Genetic influence on circulating vitamin D among Saudi Arabians.
Osteomalacia in an HIV-infected man receiving rifabutin, a cytochrome P450 enzyme inducer: a case report.
Paradoxical deterioration in seizure control due to anticonvulsant-induced hypocalcaemia.
Simultaneous measurement of 25(OH)-vitamin D and 24,25(OH)2-vitamin D to define cut-offs for CYP24A1 mutation and vitamin D deficiency in a population of 1200 young subjects.
Vitamin D Deficiency Attenuates Acute Alcohol-Induced Hepatic Lipid Accumulation in Mice.
Vitamin D pathway gene polymorphisms influenced vitamin D level among pregnant women.
Vitamin D Status in Russian Children and Adolescents: Contribution of Genetic and Exogenous Factors.
vitamin d3 24-hydroxylase deficiency
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
Vitamin E Deficiency
Effects of vitamin E deficiency on hepatic microsomal cytochrome P450 and phase II enzymes in male and female rats.
Increasing lipid peroxidation by vitamin E deficiency does not augment adriamycin-induced inhibition of hepatic drug metabolism.
Vitamin E deficiency accelerates nitrate tolerance via a decrease in cardiac P450 expression and increased oxidative stress.
Vitamin K Deficiency
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin or 2,2',4,4',5,5'-hexachlorobiphenyl on vitamin K-dependent blood coagulation in male and female WAG/Rij-rats.
The sample that would not clot.
Vitiligo
Association of CYP2C9 Genetic Variants with Vitiligo.
Urinary metabolomic investigations in vitiligo patients.
Vulvar Neoplasms
Correspondence re: C. Chen et al., CYP2D6 genotype and the incidence of anal and vulvar cancer. Cancer Epidemiol. Biomark. Prev., 8: 317-321, 1999.
CYP2D6 genotype and the incidence of anal and vulvar cancer.
Wasting Syndrome
Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.
Restoration of Dioxin-Induced Damage to Fetal Steroidogenesis and Gonadotropin Formation by Maternal Co-Treatment with ?-Lipoic Acid.
Werner Syndrome
Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver.
Whooping Cough
Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes.
Testosterone rapidly increases Ca(2+)-activated K(+) currents causing hyperpolarization in human coronary artery endothelial cells.
Williams Syndrome
Differential diagnosis of vitamin D-related hypercalcemia using serum vitamin D metabolite profiling.
Wilms Tumor
Exclusion of Wilms tumour (WT1b) and ovarian cytochrome P450 aromatase (CYP19A1) as candidates for sex determination genes in Nile tilapia (Oreochromis niloticus).
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
New frontiers on the molecular underpinnings of hypospadias according to severity.
Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis.
WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells.
Xanthomatosis
A case of Cerebrotendinous Xanthomatosis with spinal cord involvement and without tendon xanthomas: identification of a new mutation of the CYP27A1 gene.
Bilateral Femoral Neck Fractures in Cerebrotendinous Xanthomatosis Treated by Hip Arthroplasties: The First Case Report and Literature Review.
Cerebrotendinous xanthomatosis, a metabolic disease with different neurological signs: two case reports.
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review.
Clinical and genetic characteristics of Chinese patients with cerebrotendinous xanthomatosis.
Elimination of endoplasmic reticulum stress and cardiovascular, type 2 diabetic, and other metabolic diseases.
Familial variability of cerebrotendinous xanthomatosis lacking typical biochemical findings.
On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation.
Structure-function analysis of CYP27B1 and CYP27A1. Studies on mutants from patients with vitamin D-dependent rickets type I (VDDR-I) and cerebrotendinous xanthomatosis (CTX).
Xanthomatosis, Cerebrotendinous
A case of cerebrotendinous xanthomatosis mimicking the clinical phenotype of mitochondrial disease with a novel frame-shift mutation (c. 43_44 delGG) in CYP27A1 gene exon 1.
A case of cerebrotendinous xanthomatosis presenting with epilepsy as an initial symptom with a novel V413D mutation in the CYP27A1 gene.
A case of Cerebrotendinous Xanthomatosis with spinal cord involvement and without tendon xanthomas: identification of a new mutation of the CYP27A1 gene.
A Case of Late-onset Cerebrotendinous Xanthomatosis with a Novel Mutation in the CYP27A1 Gene.
A compound heterozygous mutation of CYP27A1 gene in a Taiwanese patient with cerebrotendinous xanthomatosis.
A Late-onset and Relatively Rapidly Progressive Case of Pure Spinal Form Cerebrotendinous Xanthomatosis with a Novel Mutation in the CYP27A1 Gene.
A novel frameshift mutation in the sterol 27-hydroxylase gene in an Egyptian family with cerebrotendinous xanthomatosis without cataract.
A novel mutation in the CYP27A1 gene in a family with cerebrotendinous xanthomatosis.
Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma.
Apparent underdiagnosis of Cerebrotendinous Xanthomatosis revealed by analysis of ~60,000 human exomes.
Autism spectrum disorder: an early and frequent feature in cerebrotendinous xanthomatosis.
Bilateral Femoral Neck Fractures in Cerebrotendinous Xanthomatosis Treated by Hip Arthroplasties: The First Case Report and Literature Review.
Brain diffusion tensor imaging changes in cerebrotendinous xanthomatosis reversed with treatment.
c.1263+1G>A Is a Latent Hotspot for CYP27A1 Mutations in Chinese Patients With Cerebrotendinous Xanthomatosis.
Cerebrotendinous Xanthomatosis ataxia responsive to CDCA and Riluzole.
Cerebrotendinous xanthomatosis in Spain: clinical, prognostic, and genetic survey.
Cerebrotendinous xanthomatosis with the c.379C>T (p.R127W) mutation in the CYP27A1 gene associated with premature age-associated limbic tauopathy.
Cerebrotendinous xanthomatosis, a metabolic disease with different neurological signs: two case reports.
Cerebrotendinous xanthomatosis: a comprehensive review of pathogenesis, clinical manifestations, diagnosis, and management.
Cerebrotendinous Xanthomatosis: Molecular Pathogenesis, Clinical Spectrum, Diagnosis, and Disease-Modifying Treatments.
Cerebrotendinous xanthomatosis: Possibility of founder mutation in CYP27A1 gene (c.526delG) in Eastern Indian and Surinamese population.
Cerebrotendinous xanthomatosis: recurrence of the CYP27A1 mutation p.Arg479Cys in Sardinia.
Cholestasis as a dominating symptom of patients with CYP27A1 mutations: An analysis of 17 Chinese infants.
Cholestenoic acids regulate motor neuron survival via liver X receptors.
Clinical and Genetic Characteristics of Splicing Variant in CYP27A1 in an Iranian Family with Cerebrotendinous Xanthomatosis.
Clinical and molecular diagnosis of cerebrotendinous xanthomatosis with a review of the mutations in the CYP27A1 gene.
Clinical and molecular genetic features of cerebrotendinous xanthomatosis in Taiwan: Report of a novel CYP27A1 mutation and literature review.
Clinical and molecular genetic features of cerebrotendinous xanthomatosis patients in Chinese families.
Clinical and radiological findings of a cerebrotendinous xanthomatosis patient with a novel p.A335V mutation in the CYP27A1 gene.
Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum.
Cytochrome P450s in the synthesis of cholesterol and bile acids - from mouse models to human diseases.
Distinct Binding of Cholesterol and 5beta-Cholestane-3alpha,7alpha,12alpha-triol to Cytochrome P450 27A1: Evidence from Modeling and Site-Directed Mutagenesis Studies.
Epidemiology, diagnosis, and treatment of cerebrotendinous xanthomatosis (CTX).
Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis.
Evidence for a role of sterol 27-hydroxylase in glucocorticoid metabolism in vivo.
Familial variability of cerebrotendinous xanthomatosis lacking typical biochemical findings.
Gene supplementation of CYP27A1 in the liver restores bile acid metabolism in a mouse model of cerebrotendinous xanthomatosis.
Identification of 7?,24-dihydroxy-3-oxocholest-4-en-26-oic and 7?,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma.
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.
Juvenile Cataract Morphology in 3 Siblings Not Yet Diagnosed with Cerebrotendinous Xanthomatosis.
Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS.
Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis.
Mutation in CYP27A1 identified in family with coronary artery disease.
NGS-Based Diagnosis of Treatable Neurogenetic Disorders in Adults: Opportunities and Challenges.
Novel splice-affecting variants in CYP27A1 gene in two Chilean patients with Cerebrotendinous Xanthomatosis.
Optic Neuropathy with Features Suggestive of Optic Neuritis in Cerebrotendinous Xanthomatosis.
Pathophysiology of cerebrotendinous xanthomatosis.
Patients with cerebrotendinous xanthomatosis diagnosed with diverse multisystem involvement.
Patients with Lately Diagnosed Cerebrotendinous Xanthomatosis.
Prevalence of Cerebrotendinous Xanthomatosis Among Patients Diagnosed With Acquired Juvenile-Onset Idiopathic Bilateral Cataracts.
Progressive Myoclonic Epilepsy'-like presentation of Cerebrotendinous Xanthomatosis in an Indian Family with A Novel C.646+1G>A Splice Site Mutation.
Prominent Tendon Xanthomas and Abdominal Aortic Aneurysm Associated with Cerebrotendinous Xanthomatosis Identified Using Whole Exome Sequencing.
Spinal form cerebrotendinous xanthomatosis patient with long spinal cord lesion.
Sterol 27-Hydroxylase Deficiency as a Cause of Neonatal Cholestasis: Report of 2 Cases and Review of the Literature.
Structure-function analysis of CYP27B1 and CYP27A1. Studies on mutants from patients with vitamin D-dependent rickets type I (VDDR-I) and cerebrotendinous xanthomatosis (CTX).
The first cerebrotendinous xanthomatosis family from Argentina: a new mutation in CYP27A1 gene.
The role of dentate nuclei in human oculomotor control: insights from cerebrotendinous xanthomatosis.
The wide spectrum of cerebrotendinous xanthomatosis: Case report of a rare but treatable disease.
Three siblings with Cerebrotendinous Xanthomatosis: A novel mutation in the CYP27A1 gene.
Toward newborn screening of cerebrotendinous xanthomatosis: results of a biomarker research study using 32,000 newborn dried blood spots.
Unique case of cerebrotendinous xanthomatosis revisited: All the mutations responsible for this disease are present in the CYP27A1 gene.
Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase.
[Cerebrotendinous xanthomatosis is a rare disorder, which requires a specific treatment].
[Cerebrotendinous xanthomatosis: report of 4 patients]
[Determination and hierarchy of clinical signs for early detection of cerebrotendinous xanthomatosis].
Xeroderma Pigmentosum
DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China.
Impact of Occupational Exposures and Genetic Polymorphisms on Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer.
Inter-individual variation of smoking-related DNA adducts in lymphocytes-relationship to mRNA levels for CYP1A1 and DNA repair enzymes.
Low synthesis of retinoic acid due to impaired cytochrome P450 1a1 expression in mouse xeroderma pigmentosum fibroblasts.
Preferential DNA damage in the p53 gene by benzo[a]pyrene metabolites in cytochrome P4501A1-expressing xeroderma pigmentosum group A cells.
Yellow Fever
Bacteria-mediated modification of insecticide toxicity in the yellow fever mosquito, Aedes aegypti.