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Information on EC 1.14.14.106 - taxane 13alpha-hydroxylase

for references in articles please use BRENDA:EC1.14.14.106
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IUBMB Comments
This cytochrome-P-450-dependent enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).
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The expected taxonomic range for this enzyme is: Taxus cuspidata
Synonyms
cytochrome P450 taxoid 13alpha-hydroxylase, taxoid 13alpha-hydroxylase, THY13a, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
taxa-4(20),11-dien-5alpha-ol + [reduced NADPH-hemoprotein reductase] + O2 = taxa-4(20),11-dien-5alpha,13alpha-diol + [oxidized NADPH-hemoprotein reductase] + H2O
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