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Information on EC 1.14.14.124 - dihydromonacolin L hydroxylase

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IUBMB Comments
A heme-thiolate protein (cytochrome P-450). The dehydration of 3alpha-hydroxy-3,5-dihydromonacolin L acid is believed to be spontaneous [1,2]. The enzyme from fungi also catalyses the reaction of EC 1.14.13.198, monacolin L hydroxylase .
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The enzyme appears in viruses and cellular organisms
Synonyms
LovA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3alpha-hydroxy-3,5-dihydromonacolin L acid = monacolin L acid + H2O
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dihydromonacolin L acid + O2 + [reduced NADPH-hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
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dihydromonacolin L acid + O2 + [reduced NADPH-hemoprotein reductase] = monacolin L acid + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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