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Information on EC 1.14.14.126 - beta-amyrin 28-monooxygenase

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IUBMB Comments
The enzyme, found in plants, is involved in the biosynthesis of oleanane-type triterpenoids, such as ginsenoside Ro. The enzyme from Medicago truncatula (barrel medic) (CYP716A12) can also convert alpha-amyrin and lupeol to ursolic acid and betulinic acid, respectively. The enzyme from Maesa lanceolata (false assegai) (CYP16A75) does not catalyse the reaction to completion, resulting in accumulation of both intermediates.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
cyp716a12, cyp716a52v2, cyp716a179, cyp716a253, triterpene c-28 oxidase, cyp716a94, cyp716a244, cyp716a140v2, cyp716a254, amyrin c-28 oxidase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
beta-amyrin + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = oleanolate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
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beta-amyrin + O2 + [reduced NADPH-hemoprotein reductase] = erythrodiol + [oxidized NADPH-hemoprotein reductase] + H2O
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erythrodiol + O2 + [reduced NADPH-hemoprotein reductase] = oleanolic aldehyde + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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oleanolic aldehyde + O2 + [reduced NADPH-hemoprotein reductase] = oleanolate + [oxidized NADPH-hemoprotein reductase] + H2O
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PATHWAY SOURCE
PATHWAYS
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