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Information on EC 1.14.14.131 - bursehernin 5'-monooxygenase

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IUBMB Comments
A cytochrome P-450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum. The enzyme is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
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The expected taxonomic range for this enzyme is: Sinopodophyllum hexandrum
Synonyms
bursehernin 5'-hydroxylase, CYP71CU1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(-)-bursehernin + [reduced NADPH-hemoprotein reductase] + O2 = (-)-5'-demethylyatein + [oxidized NADPH-hemoprotein reductase] + H2O
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