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Information on EC 1.14.14.132 - (-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase

for references in articles please use BRENDA:EC1.14.14.132
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IUBMB Comments
This cytochrome P-450 enzyme, characterized from the plant Sinopodophyllum hexandrum, produces the direct precursor to etoposide, a potent anticancer drug. It can also act on (-)-deoxypodophyllotoxin with lower efficiency.
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The expected taxonomic range for this enzyme is: Sinopodophyllum hexandrum
Synonyms
CYP82D61, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(-)-4'-demethyldeoxypodophyllotoxin + [reduced NADPH-hemoprotein reductase] + O2 = (-)-4'-demethylepipodophyllotoxin + [oxidized NADPH-hemoprotein reductase] + H2O
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PATHWAY SOURCE
PATHWAYS
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