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Information on EC 1.14.14.139 - 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase

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IUBMB Comments
A heme-thiolate protein (P-450). This is the key enzyme in the biosynthesis of the bile acid cholic acid (3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoic acid). The activity of this enzyme determines the biosynthetic ratio between cholic acid and chenodeoxycholic acid . The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent .
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Word Map
  • 1.14.14.139
  • bile
  • epoxide
  • cholic
  • epoxyeicosatrienoic
  • 7alpha-hydroxylase
  • chenodeoxycholic
  • cyp7a1
  • 4alpha
  • farnesoid
  • nadph-cytochrome
  • alpha1-fetoprotein
  • hnf4alpha
  • arg287gln
The enzyme appears in viruses and cellular organisms
Synonyms
cytochrome p-450 lm4, sterol 12alpha-hydroxylase/cyp8b1, 12-alpha-hydroxylase, 12alpha-hydroxylase gene, sterol 12alpha hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5beta-cholestane-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
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PATHWAY SOURCE
PATHWAYS
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