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Information on EC 1.14.14.150 - costunolide synthase

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IUBMB Comments
A heme-thiolate protein (P-450). The enzyme hydroxylates carbon C-6 of germacra-1(10),4,11(13)-trien-12-oate to give 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate, which probably spontaneously cyclises to form the lactone ring.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
(+)-costunolide synthase, cyp71bl3, cyp71bl5, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate = (+)-costunolide + H2O
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(1c), spontaneous
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germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 = (+)-costunolide + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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overall reaction
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germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 = 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1a)
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