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Information on EC 1.14.14.161 - nepetalactol monooxygenase

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IUBMB Comments
The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P-450 (heme thiolate) protein. It catalyses three successive reactions in the pathway leading to biosynthesis of monoterpenoid indole alkaloids.
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The expected taxonomic range for this enzyme is: Catharanthus roseus
Synonyms
7-deoxyloganetic acid synthase, 7-deoxyloganic acid synthase;, 7DLS, CYP76A26, iridoid oxidase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
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overall reaction
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(+)-cis,trans-nepetalactol + [reduced NADPH-hemoprotein reductase] + O2 = 7-deoxyloganetic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
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(1a)
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7-deoxyloganetic alcohol + [reduced NADPH-hemoprotein reductase] + O2 = iridotrial + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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(1b)
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iridotrial + [reduced NADPH-hemoprotein reductase] + O2 = 7-deoxyloganetate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1c)
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